Digital Commons Network^™

Intergenerational Protective Anti-Gut Commensal Immunoglobulin G Originates In Early Life, Brigida Rusconi, Adina K Bard, Ryan Mcdonough, Angel M Kindsvogel, Jacqueline D Wang, Sreeram Udayan, Keely G Mcdonald, Rodney D Newberry, Phillip I Tarr

2020-Current year OA Pubs

Maternal immunoglobulins of the class G (IgGs) protect offspring from enteric infection, but when, where, and how these antibodies are physiologically generated and confer protection remains enigmatic. We found that circulating IgGs in adult mice preferentially bind early-life gut commensal bacteria over their own adult gut commensal bacteria. IgG-secreting plasma cells specific for early-life gut bacteria appear in the intestine soon after weaning, where they remain into adulthood. Manipulating exposure to gut bacteria or plasma cell development before, but not after, weaning reduced IgG-secreting plasma cells targeting early-life gut bacteria throughout life. Further, the development of this anti-gut commensal IgG …

Examining The Factors Impacting The Undergraduate Degree Performance In The College Of Business At Southern Univeristy And Agriculture & Mechanical College, Brian D. Adams

USF Tampa Graduate Theses and Dissertations

This dissertation investigates factors influencing undergraduate degree performance in the College of Business at Southern University and Agricultural and Mechanical College. The research employes a qualitative approach, utilizing in-depth interviews with faculty and students to identify challenges and strategies for enhancing academic outcomes. Key themes identified include the impact of faculty mentorship, curriculum relevance, technological integration, and institutional support on student success. The study examines undergraduate degree performance in the unique context of a historically black college and university (HBCU).

Findings reveal that faculty and students prioritize teaching quality, curriculum relevance, and supportive services as vital for academic success. Challenges …

Problem-Solving In The Preparation Of Teachers For Agricultural Education: A Mixed Methods Study Investigating The Effect Of Metacognitive Awareness And Cognitive Ability On Students Enrolled In An Introductory Agricultural Mechanics Course, Whitney Figland

LSU Doctoral Dissertations

Cognitive and metacognitive ability have been identified as a critical factor that influences individuals to successfully problem-solve. However, recent research has indicated that students do not have the necessary 21st-century skills to be successful in the workplace. This issue has been confounded by the lack of school-based agricultural education (SBAE) teachers’ limited knowledge regarding effectively teaching decision-making skills and the use of teaching methods that promote problem-solving. Therefore, this study sought to understand the effect that cognitive and metacognitive ability had on the problem-solving of students who are enrolled in an Introduction to Agricultural Mechanics course at Louisiana State University. …

Aggressive Behaviors Related To Delirium In Hospitalized Older Adults: A Systematic Review, Julia D. Trahan

LSU Master's Theses

This is a systematic review of the aggressive behaviors related to delirium in hospitalized older adults. The objective of this study was to review relevant literature regarding the moderation of delirious related aggressive behaviors within a hospital setting and examining the extent of interventions being conducted with aggression being a main factor. The eligibility factors for studies to be included were as follows: diagnosis of delirium, aggressive behaviors or agitation present, study occurring within a hospital setting, the goal of preventing aggressive behaviors, and participants must be over the age of 65. Academic Search Complete, PsychINFO, MEDLINE, SocINDEX, CINHAL Complete …

The Impacts Of Nature-Based Sediment Restoration Practices On Coastal Wetland Soil Biogeochemistry, Jacob Z. Cheng

LSU Master's Theses

Coastal marshes provide many valuable ecosystem services. However, these wetlands are threatened worldwide, being subject to sea level rise, sediment starvation, subsidence, coastal edge erosion, etc. Many efforts are being made to counteract this wetland loss and preserve the ecosystem services. Two such methods are sediment diversion and the thin layer placement (TLP) of dredged sediment.

Sediment diversion involves reconnecting the main channel of a river body to disconnected wetlands, supplying much needed soil-building materials. However, this method affects the salinity of the waters, introducing large amounts of freshwater into the system. Salinity changes can affect marsh biogeochemistry. Most ecological …

Identifying Potential Dietary Treatments For Inherited Metabolic Disorders Using Drosophila Nutrigenomics, Felipe Martelli, Jiayi Lin, Sarah Mele, Wendy Imlach, Oguz Kanca, Christopher K Barlow, Jefferson Paril, Ralf B Schittenhelm, John Christodoulou, Hugo J Bellen, Matthew D W Piper, Travis K Johnson

Faculty, Staff and Students Publications

Inherited metabolic disorders are a group of genetic conditions that can cause severe neurological impairment and child mortality. Uniquely, these disorders respond to dietary treatment; however, this option remains largely unexplored because of low disorder prevalence and the lack of a suitable paradigm for testing diets. Here, we screened 35 Drosophila amino acid disorder models for disease-diet interactions and found 26 with diet-altered development and/or survival. Using a targeted multi-nutrient array, we examine the interaction in a model of isolated sulfite oxidase deficiency, an infant-lethal disorder. We show that dietary cysteine depletion normalizes their metabolic profile and rescues development, neurophysiology, …

The Genomic And Evolutionary Landscapes Of Anaplastic Thyroid Carcinoma, Peter Y F Zeng, Stephenie D Prokopec, Stephen Y Lai, Nicole Pinto, Michelle A Chan-Seng-Yue, Roderick Clifton-Bligh, Michelle D Williams, Christopher J Howlett, Paul Plantinga, Matthew J Cecchini, Alfred K Lam, Iram Siddiqui, Jianxin Wang, Ren X Sun, John D Watson, Reju Korah, Tobias Carling, Nishant Agrawal, Nicole Cipriani, Douglas Ball, Barry Nelkin, Lisa M Rooper, Justin A Bishop, Cathie Garnis, Ken Berean, Norman G Nicolson, Paul Weinberger, Ying C Henderson, Christopher M Lalansingh, Mao Tian, Takafumi N Yamaguchi, Julie Livingstone, Adriana Salcedo, Krupal Patel, Frederick Vizeacoumar, Alessandro Datti, Liu Xi, Yuri E Nikiforov, Robert Smallridge, John A Copland, Laura A Marlow, Martin D Hyrcza, Leigh Delbridge, Stan Sidhu, Mark Sywak, Bruce Robinson, Kevin Fung, Farhad Ghasemi, Keith Kwan, S Danielle Macneil, Adrian Mendez, David A Palma, Mohammed I Khan, Mushfiq Shaikh, Kara M Ruicci, Bret Wehrli, Eric Winquist, John Yoo, Joe S Mymryk, James W Rocco, David Wheeler, Steve Scherer, Thomas J Giordano, John W Barrett, William C Faquin, Anthony J Gill, Gary Clayman, Paul C Boutros, Anthony C Nichols

Faculty, Staff and Student Publications

Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes. Further, different cancer driver genes are mutated in anaplastic and differentiated thyroid …

Exploring The Associations Between Drug Resistant Mutations, Low-Level Viremia, And Virological Failure In Persons With Hiv In Florida, Adriana Campos

USF Tampa Graduate Theses and Dissertations

Virologic suppression is an essential part to a successful regimen for Persons with HIV (PWH) and the 95-95-95 initiative. Yet, PWH experiencing episodes of low-level viremia (LLV) may be more prone to experience virological failure (VF). Currently, studies debate the clinical relevance of LLV and its effect on virological outcomes, but none have explored its interconnectedness with drug resistant mutations (DRM) and antiretroviral treatment (ART) adherence – all integral elements in predicting virological outcomes.

The goal of the proposed study was to contribute to the knowledge gap regarding the interconnectivity of drug resistant mutations, low-level viremia, adherence, and virological failure …

Quality Improvement In Healthcare: A Practical Guide For Providers (Part 3), Jeremy Ellis

Transformative Medicine

No abstract provided.

Novel Drug Approvals 2023, Emily Wagner, Christina Swiger, Mary Hoang, Maley Zents

Transformative Medicine

This article provides an overview of the novel drugs approved for 2023. The Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research (CDER) provides standards to drug developers. The CDER sets standards for required data needed in the drug development and application process. Every year a variety of new drugs and biological products are approved. Some are new molecular compounds while others are structurally similar to those already on the market. Therefore, products may not have been used in medical practice previously while others have already been used in practice. This article highlights medications that are new in …

New Onset Dyspnea In A Patient With Pacemaker, What Does The Ecg Tracing Show?, Jakob Nypaver, Robert Libera Do, Arun Kundra, Ravi Choxi

Transformative Medicine

Dual chamber pacemakers are programmed to allow for AV synchrony. Whenever a patient with a dual chamber pacemaker with underlying sinus rhythm presents with AV dissociation, the lack of AV synchrony should be questioned. The authors present a case of new onset dyspnea diagnosed as pacemaker syndrome. The diagnosis was initially delayed due to underlying ventricular paced rhythm as misidentified as normal pacemaker behavior.

A 69-year-old female with a past medical history of 2:1 atrioventricular block status post dual-chamber pacemaker implant presented with complaints of new onset shortness of breath and dyspnea. The ECG showed a ventricular rate of 66 …

Metformin Continuation Versus Holding Pre And Post Coronary Angiography With Normal Renal Function: A Systematic Review And Meta-Analysis, Mohammad Hamza, Yasar Sattar, Sadaf Fakhra, Neel Patel, Mubashar Karamat, Saman Razzaq, Aamir Saeed, Khaled M. Harmouch, Islam Elgendy, Mamas Mamas, Anand Prasad, Wael Aljaroudi, Ramesh Daggubati, M Chadi Alraies

Transformative Medicine

Background

It is common practice to withhold metformin prior to cardiac catheterization due to fear of developing lactic acidosis in the setting of contrast-associated acute kidney injury (AKI). The evidence behind this recommendation is currently weak.

Methods

We collected 851 articles from PubMed and Embase, of which 3 met our inclusion criteria. Inclusion criteria were age > 18 years, baseline use of long-term metformin with continued or interrupted metformin use in patients during diagnostic or interventional cardiac catheterization. The outcomes studied were differences between post-catheterization and pre-catheterization serum creatinine (SCr) and glomerular filtration rate (GFR). We excluded studies dealing with patients …

Empathy, Education, & Empowerment: Reflections On The World Of Dementia, Samantha Heyer, Jordan Neely, Sarah Stegge, Elaine M. Eshbaugh

Research in the Capitol

At the Dementia Simulation House, we offer the opportunity for participants to experience what life may be like for someone living with dementia in a home setting. About 80% of individuals living with dementia live at home in the community, and we aim to show participants what it might be like for these individuals to complete chores and activities of daily living. During the simulation, we put gear on an individual to simulate dementia. Then participants go through a debriefing which involves writing a reaction word. We sorted the reaction words and calculated percentages on the popularity/common phrases or words …

An Automated Method To Detect Tooth Brushing Activity With Smartwatch Sensors, Blake Schleter, Marina Avdonina, Rishiraj Adhikary, Dheryta Jaisinghani, Sougata Sen

Research in the Capitol

Nearly half (46%) of all adults aged 30 years or older show signs of gum disease; severe gum disease affects about 9% of adults.

Brushing your teeth is an incredibly important part of taking care of your oral health and daily hygiene. Dentists recommend that you should brush your teeth twice a day for periods of at least two minutes to achieve adequate results and promote oral health.

Currently, there are very limited solutions available to help people easily and efficiently track their tooth brushing activity.

An Argument For Expanding Research On Quantitative Pedagogical Content Knowledge, Randall E. Groth

Numeracy

Pedagogical content knowledge (PCK) traditionally has been used in research concerning prospective and practicing classroom teachers. This essay argues that PCK is also relevant to other professions including those advancing quantitative reasoning (QR). To illustrate, the case of PCK for teaching QR is considered. Those in fields such as public health, journalism, meteorology, and government increasingly find themselves responsible for helping the public understand an ever-growing amount of quantitative information that has a bearing on societal well-being. Several examples illustrate how such professionals’ responsibilities require knowing prevalent QR patterns in society, strategies for fostering sound reasoning, and the general nature …

Highly Available Te Path Management For Delegated Paths Across Multiple Pces Without East-West Communication Between Pces, Anonymous

Defensive Publications Series

The present disclosure relates to Traffic Engineering path management with Path Computation Elements (PCEs). Specifically, we allow TE paths to stay in a PCE throughout the entire TE path lifecycle. There is a new “controlling” setting to determine whether the PCE is active for that TE path, allowing the PCE to keep the TE path in its inventory even when it does not have control of the TE path. This uses existing work in the Path Computation Client (PCC) to determine its active and backup PCE by listening to what the PCE Protocol (PCEP) says about delegation of the various …

The Utah Statesman, March 25, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Overcoming The Achievement Gap: Arkansas' Utilization Of Weighted Student Funding To Support Students Of Poverty, Michael G. Mcfetridge

ATU Theses and Dissertations 2021 - Present

With over 63% of its students living in poverty, the state of Arkansas has a challenge when it comes to equitable funding and opportunities for its students. One funding mechanism that has been in place in Arkansas for over 20 years now is a categorical funding allocation known as Enhanced Student Achievement Funds (ESA). School districts receive these funds based on their percentage of students in poverty. While this weighted student funding model of allocating more funds to identified characteristics has been in place in Arkansas for over two decades, little research exists to gauge whether these allocation mechanisms successfully …

Underwater Double Vortex Generation Using 3d Printed Acoustic Lens And Field Multiplexing, Chadi Ellouzi, Ali Zabihi, Farhood Aghdasi, Aidan Kayes, Milton Rivera, Jiaxin Zhong, Amir Miri, Chen Shen

Henry M. Rowan College of Engineering Departmental Research

The generation of acoustic vortex beams has attracted an increasing amount of research attention in recent years, offering a range of functions, including acoustic communication, particle manipulation, and biomedical ultrasound. However, incorporating more vortices and broadening the capacity of these beams and associated devices in three dimensions pose challenges. Traditional methods often necessitate complex transducer arrays and are constrained by conditions such as system complexity and the medium in which they operate. In this paper, a 3D printed acoustic lens capable of generating a double vortex pattern with an optional focusing profile in water was demonstrated. The performance of the …

Single Mother Leaders Improving Organizational Employees’ Good Health And Well-Being During The Covid-19 Pandemic, Emmanuel Ifeoma Nwogor

Walden Dissertations and Doctoral Studies

No abstract provided.

Targeting Mitochondrial Dysfunction Using Methylene Blue Or Mitoquinone To Improve Skeletal Aging., Sher Bahadur Poudel, Dorra Frikha-Benayed, Ryan R Ruff, Gozde Yildirim, Manisha Dixit, Ron Korstanje, Laura Robinson, Richard A Miller, David E Harrison, John R Strong, Mitchell B Schaffler, Shoshana Yakar

Faculty Research 2024

Methylene blue (MB) is a well-established antioxidant that has been shown to improve mitochondrial function in both in vitro and in vivo settings. Mitoquinone (MitoQ) is a selective antioxidant that specifically targets mitochondria and effectively reduces the accumulation of reactive oxygen species. To investigate the effect of long-term administration of MB on skeletal morphology, we administered MB to aged (18 months old) female C57BL/J6 mice, as well as to adult male and female mice with a genetically diverse background (UM-HET3). Additionally, we used MitoQ as an alternative approach to target mitochondrial oxidative stress during aging in adult female and male …

Dissociating Reading And Auditory Comprehension In Persons With Aphasia, Rachel M. Harrington, Sigfus Kristinsson, Janina Wilmskoetter, Natalie Busby, Dirk Den Ouden, Chris Rorden, Julius Fridriksson Ph.D., Leonardo Bonilha

Faculty Publications

Language comprehension is often affected in individuals with post-stroke aphasia. However, deficits in auditory comprehension are not fully correlated with deficits in reading comprehension and the mechanisms underlying this dissociation remain unclear. This distinction is important for understanding language mechanisms, predicting long-term impairments and future development of treatment interventions. Using comprehensive auditory and reading measures from a large cohort of individuals with aphasia, we evaluated the relationship between aphasia type and reading comprehension impairments, the relationship between auditory versus reading comprehension deficits and the crucial neuroanatomy supporting the dissociation between post-stroke reading and auditory deficits. Scores from the Western Aphasia …

Transformational Experiences And Decision-Making Processes: Factors Influencing The Choice Of College Major, Ashley Hunsaker

Undergraduate Honors Theses

This thesis examines the influence of transformational experiences on decision making when it comes to choosing one’s major. Participants attended a one-on-one interview with the primary researcher where questions were asked about how they chose their major and how much they enjoy it. Participants were given the chance to tell stories about how they discovered their major and how they decided to pursue it. Results suggested that transformational experiences, internal and external factors, and mentorship led students to choose and stick with a major where they felt a sense of belonging and “fit.” When belonging and perceived fit were not …

Coal-Rock Interface Imaging Based On Acoustic Remote Reflection Logging Within Crossing Boreholes Using The Finite Element Method, Xu Hongyang, Zhai Cheng, Xia Jigen, Sun Yong, Dong Xingmeng, Lai Yongshuai, Yu Xu, Xu Jizhao, Cong Yuzhou

Coal Geology & Exploration

The presence of small geological structures is the main cause of coal and gas outbursts, making the precise detection of these structures an urgent need. High-precision detection of coal-rock interfaces is essential for identifying small structures and achieving transparent mining faces. The acoustic remote reflection logging technology, with a large detection range, a high resolution, and imaging capability, can accurately identify coal-rock interfaces. In this context, this study proposed a technique for coal-rock interface detection based on acoustic remote reflection logging within crossing boreholes. Specially, by placing acoustic detectors in crossing boreholes, the array waveforms generated by the coal-rock interfaces …

Factorization In Cybersecurity: A Dual Role Of Defense And Vulnerability In The Age Of Quantum Computing, Himateja Arukala

Theses and Dissertations

One of the most critical components of modern cryptography and thus cybersecurity is the ability to factor large integers quickly and efficiently. RSA encryption, one of the most used types, is based largely on the assumption that factoring for large numbers is computationally infeasible for humans and computers alike. However, with quantum computers, people can use an algorithm like Shor’s algorithm to perform the same task exponentially faster than any normal device ever could. This investigation will go into the strength and vulnerability of RSA encryption using the power of factorization in an age of quantum computers.We start by looking …

Road Maintenance Through Machine Learning, Yashwanth Sai Rachala

Theses and Dissertations

This thesis explores the use of machine learning techniques for road infrastructure maintenance. We propose an innovative machine learning-based approach to improve the efficiency and effectiveness of road maintenance strategies. The focal point of this investigation is the development and implementation of a machine learning framework to enhance road quality monitoring. We use Long Short-Term Memory (LSTM) networks to accurately predict future road conditions and identify potential areas requiring maintenance before significant deterioration occurs. This predictive approach is designed to enable a shift from reactive to proactive road maintenance, optimizing the use of limited resources and improving overall road safety. …

Asset Pricing Bubbles In Agricultural Commodities, Samuel Riffle

Theses and Dissertations

Recent asset pricing bubble bursts in some markets beg the question of whether bubbles exist in others. Determining whether they exist has been investigated for years, with various approaches. This paper combines the Engle-Granger technique with a GSADF test to test for bubbles in corn and soybean futures prices. I attempt to find measures for the market fundamentals of the futures, employing PPIs and costs of production for each commodity. My findings provide some evidence for the existence of bubbles, though the results are not definitive. Overall, the findings imply a possibility for bubbles but also apossibility of true increases …

Usa V. Mark Jordan

2024 Decisions

USDC for the Eastern District of Pennsylvania

Usa V. Jonathan Wiktorchik,Jr.

2024 Decisions

USDC for the Eastern District of Pennsylvania

City Of Jersey City V. Jersey City Community Housing Corp

2024 Decisions

USDC for the District of New Jersey