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First-Generation College Students And Sense Of Belonging At School: The Moderating Effect Of Remote Learning, Christina Su Ju Apr 2024

First-Generation College Students And Sense Of Belonging At School: The Moderating Effect Of Remote Learning, Christina Su Ju

Psychology Theses & Dissertations

This study examines the effect of first-generation college student status on students’ sense of belonging, and whether remote learning moderates this effect. Specifically, this study examines whether first-generation college students’ sense of belonging at university differs from their continuing-generation college student counterpart, and whether taking remote courses impacts that relationship. It was hypothesized that first-generation college students would report lower sense of belonging than continuing-generation college students, and that remote learning would moderate the relationship such that the negative effect of first-generation student status on sense of belonging is strengthened when the student takes more remote courses. Survey data from …


Online Learning As A Tool For Accessibility For Autistic Higher Education Students, Keirnan E. Brown Apr 2024

Online Learning As A Tool For Accessibility For Autistic Higher Education Students, Keirnan E. Brown

STEMPS Theses & Dissertations

Online learning is becoming more prevalent (Aylmer, 2020) and institutions are seeing an increase in disabled students (HEFCE, 2017; Italian National Agency for the Evaluation of the University System and Research [ANVUR], & National Conference of University Delegates for Disability [CNUDD], 2021; Rao, Edelen-Smith, & Wailehua, 2015). Meanwhile, this group experiences an achievement gap concerning learning and outcomes (ECU, 2017; Eurostat, 2014; Eurostat, 2019; Pearson et al., 2019). Therefore, exploring potential uses of online learning may be beneficial. One related use for online learning is its potential as a tool for accessibility for autistic students. Moreover, a literature gap exists …


Exploring The Experiences Of School Counselors Advocating For Social Justice Within Urban Pk-12 Charter Schools, Betsy Marina Perez Apr 2024

Exploring The Experiences Of School Counselors Advocating For Social Justice Within Urban Pk-12 Charter Schools, Betsy Marina Perez

Counseling & Human Services Theses & Dissertations

School counselors serve students’ academic, career, and social/emotional needs through a comprehensive school counseling program, and center their work on concepts of equity, advocacy, social justice, and systemic change, to remove barriers and increase opportunities for all PK-12 students. Charter schools are also unique public school settings as they offer flexibility, innovation, and autonomy to staff to create individualized experiences for their students. Held in common by these two educational services is the commitment to serving the needs of historically marginalized populations (Black, Indigenous, People of Color [BIPOC] and those from low socioeconomic backgrounds) and the opportunity to advocate for …


Developing Intercultural Competence And Cultural Capital: Applying Virtual Reality To Study Abroad Pedagogy, Jenifer Butler Apr 2024

Developing Intercultural Competence And Cultural Capital: Applying Virtual Reality To Study Abroad Pedagogy, Jenifer Butler

English Theses & Dissertations

As the world becomes increasingly globalized thanks, at least in part, to the ubiquity of digital technology, scholars in discourse and new media must explore the possibility of learning and composition to expand pedagogical practices and opportunities. This project uses study abroad programs and education as a test case for establishing the feasibility of easily incorporating existing virtual reality (VR) technology into the classroom. It examines the theoretical and technological question of whether advancements in virtual reality have achieved the potential for practical pedagogical applications, and if virtual technology can provide responsible, accurate, and educational access to concepts as complex …


Innocence Through An Intersectional Lens: An Examination Of Women And Wrongful Convictions, Briana Paige Apr 2024

Innocence Through An Intersectional Lens: An Examination Of Women And Wrongful Convictions, Briana Paige

Sociology & Criminal Justice Theses & Dissertations

According to The National Registry of Exonerations (2022), nearly 40% of all exonerations involve a no-crime wrongful conviction. While women make up less than 10% of all exonerees, nearly 73% of exonerated women were originally convicted of crimes that never happened, compared to only 38% of exonerated men. Despite their prevalence, the topic of no crime wrongful convictions is extremely understudied in the wrongful conviction literature.

Additionally, since prior research on wrongful convictions has been primarily male centered, the likelihood that a woman’s case will be accepted to be reviewed for innocence is significantly lower than men (Free and Ruesink, …


Autism At Work Across The Career Span: A Scoping Review, Kate Noel Warnock Apr 2024

Autism At Work Across The Career Span: A Scoping Review, Kate Noel Warnock

Psychology Theses & Dissertations

This scoping review takes a career-span approach to the experiences of autistic people at work. Using Super’s (1994) life-span, life-space theory as a framework, I divided the literature into five career phases: Growth, Exploration, Establishment, Maintenance, and Disengagement. In each phase, I reviewed the challenges and facilitators that autistic people face, highlighting themes that have strong support in the literature, and areas that need further examination in future research. Additionally, I argue that Super’s career framework is not the most parsimonious way to describe the career trajectories of autistic individuals and propose modifications to the framework to better represent their …


Understanding The Role Of Adverse Childhood Experiences On Resilience In Police Officers, Wayne F. Handley Apr 2024

Understanding The Role Of Adverse Childhood Experiences On Resilience In Police Officers, Wayne F. Handley

Counseling & Human Services Theses & Dissertations

Police officers are subject to a variety of stressors not only from job-related events resulting from direct or vicarious trauma exposure (Andersen & Papazoglou, 2014; Brown et al., 1999; Iversen et al., 2008) but also from family and personal concerns (Burke, 1998; Page & Jacobs, 2011), and administrative pressures originating from within their own agencies (Violanti et al., 2018; White et al., 2016). Prior to their careers as police officers, individuals may also be exposed to traumatic events early in life. Adverse Childhood Experiences (ACEs) are described as negative events related to emotional, physical, or sexual abuse or neglect, exposure …


Advancing Data-Driven Decision Making For Transportation Safety: Emerging Trends, Statistical Modeling, And Causal Inference, Guocong Zhai Apr 2024

Advancing Data-Driven Decision Making For Transportation Safety: Emerging Trends, Statistical Modeling, And Causal Inference, Guocong Zhai

Civil & Environmental Engineering Theses & Dissertations

Despite recent advances in data-driven decision-making for transportation safety, there remain potential biases in the decision-making for emerging trends (i.e., shared mobility, safe systems, vehicle electrification, and equity) in transportation. In that case, this dissertation aims to facilitate robust and equitable data-driven decision-making in transportation safety, addressing the potential biases: 1) spatial and inherent correlations across different types of crashes, 2) measurement error biases of exposures, 3) confounding biases, and 4) disparity biases in transportation safety.

To be more specific, four research objectives are demonstrated below. Chapter 3 assessed the safety performance of taxi and ride-hailing services by a multivariate …


Thermo-Elasto-Plastic Stability Of Biaxially Loaded Hollow Rectangular Section Steel Beam-Columns With Applied Torsion, George Adomako Kumi Apr 2024

Thermo-Elasto-Plastic Stability Of Biaxially Loaded Hollow Rectangular Section Steel Beam-Columns With Applied Torsion, George Adomako Kumi

Civil & Environmental Engineering Theses & Dissertations

Presented herein is an experimental and theoretical study of biaxially loaded hollow rectangular section steel beam-columns with applied torsion at elevated temperatures. The theoretical analysis is based on a system of simultaneous materially nonlinear differential equations of equilibrium for which an iterative semi-analytic solution approach is formulated. Although the primary goal of this research is to study the influence of elevated temperatures on the steel member with the complex loading, rigorous analysis is also conducted of the member at ambient temperature for comparison. The experimental part of the study involves conducting tests on the members at both ambient and high …


Pulsed-Power Neutron Production With Deuterated Polymer Accelerator Targets, Anthony O. Hagey, Juan J. Manfredi, Whitman T. Dailey, S. L. Jackson, E. R. Kaiser, J, W. Schumer Apr 2024

Pulsed-Power Neutron Production With Deuterated Polymer Accelerator Targets, Anthony O. Hagey, Juan J. Manfredi, Whitman T. Dailey, S. L. Jackson, E. R. Kaiser, J, W. Schumer

Faculty Publications

This document presents an investigation of the effect of deuterated accelerator targets on the neutron fluence from a local mass injection dense plasma focus (LMIDPF) driven by the United States Naval Research Laboratory's (NRL) Hawk pulsed-power generator. Deuterated targets were made using two methods: a well-established thin-film casting technique for flat targets and a more novel additive manufacturing technique that allowed targets to be three-dimensional (3D) printed in both flat and conical geometries. These targets were then tested during neutron-producing experiments conducted using Hawk, and theneutron fluences measured for the various target types were compared. Additive manufacturing was used as …


Dietary Magnesium Replacement For Prevention Of Hypomagnesemia In Patients With Ovarian Cancer Receiving Carboplatin-Based Chemotherapy, Wenli Liu, Larissa Meyer, Meroë Morse, Yisheng Li, Juhee Song, Rosalinda Engle, Gabriel Lopez, Santhosshi Narayanan, Pamela T Soliman, Lois Ramondetta, Eduardo Bruera, Lorenzo Cohen Apr 2024

Dietary Magnesium Replacement For Prevention Of Hypomagnesemia In Patients With Ovarian Cancer Receiving Carboplatin-Based Chemotherapy, Wenli Liu, Larissa Meyer, Meroë Morse, Yisheng Li, Juhee Song, Rosalinda Engle, Gabriel Lopez, Santhosshi Narayanan, Pamela T Soliman, Lois Ramondetta, Eduardo Bruera, Lorenzo Cohen

Faculty, Staff and Student Publications

Purpose: Hypomagnesemia is a common side effect of platinum-based chemotherapy and predicts poor overall survival in some cancers. Standard magnesium replacement strategies are often inadequate for maintaining magnesium levels. We hypothesized that a daily dietary magnesium replacement approach through magnesium-rich foods would help maintain adequate magnesium levels during platinum-based treatment.

Materials and methods: We conducted a prospective feasibility study of magnesium-rich diets in patients 18 years and older with previously untreated ovarian cancer scheduled to receive carboplatin-containing chemotherapy of at least six consecutive cycles. Education about magnesium-rich diets was provided at enrollment and then weekly during chemotherapy. Feasibility was defined …


A Randomized, Non-Comparative Phase 2 Study Of Neoadjuvant Immune-Checkpoint Blockade In Retroperitoneal Dedifferentiated Liposarcoma And Extremity/Truncal Undifferentiated Pleomorphic Sarcoma, Christina L Roland, Elise F Nassif Haddad, Emily Z Keung, Wei-Lien Wang, Alexander J Lazar, Heather Lin, Manoj Chelvanambi, Edwin R Parra, Khalida Wani, B Ashleigh Guadagnolo, Andrew J Bishop, Elizabeth M Burton, Kelly K Hunt, Keila E Torres, Barry W Feig, Christopher P Scally, Valerae O Lewis, Justin E Bird, Ravin Ratan, Dejka Araujo, M Alexandra Zarzour, Shreyaskumar Patel, Robert Benjamin, Anthony P Conley, J Andrew Livingston, Vinod Ravi, Hussein A Tawbi, Patrick P Lin, Bryan S Moon, Robert L Satcher, Bilal Mujtaba, Russell G Witt, Raymond S Traweek, Brandon Cope, Rossana Lazcano, Chia-Chin Wu, Xiao Zhou, Mohammad M Mohammad, Randy A Chu, Jianhua Zhang, Ashish Damania, Pranoti Sahasrabhojane, Taylor Tate, Kate Callahan, Sa Nguyen, Davis Ingram, Rohini Morey, Shadarra Crosby, Grace Mathew, Sheila Duncan, Cibelle F Lima, Jean-Yves Blay, Wolf Herman Fridman, Kenna Shaw, Ignacio Wistuba, Andrew Futreal, Nadim Ajami, Jennifer A Wargo, Neeta Somaiah Apr 2024

A Randomized, Non-Comparative Phase 2 Study Of Neoadjuvant Immune-Checkpoint Blockade In Retroperitoneal Dedifferentiated Liposarcoma And Extremity/Truncal Undifferentiated Pleomorphic Sarcoma, Christina L Roland, Elise F Nassif Haddad, Emily Z Keung, Wei-Lien Wang, Alexander J Lazar, Heather Lin, Manoj Chelvanambi, Edwin R Parra, Khalida Wani, B Ashleigh Guadagnolo, Andrew J Bishop, Elizabeth M Burton, Kelly K Hunt, Keila E Torres, Barry W Feig, Christopher P Scally, Valerae O Lewis, Justin E Bird, Ravin Ratan, Dejka Araujo, M Alexandra Zarzour, Shreyaskumar Patel, Robert Benjamin, Anthony P Conley, J Andrew Livingston, Vinod Ravi, Hussein A Tawbi, Patrick P Lin, Bryan S Moon, Robert L Satcher, Bilal Mujtaba, Russell G Witt, Raymond S Traweek, Brandon Cope, Rossana Lazcano, Chia-Chin Wu, Xiao Zhou, Mohammad M Mohammad, Randy A Chu, Jianhua Zhang, Ashish Damania, Pranoti Sahasrabhojane, Taylor Tate, Kate Callahan, Sa Nguyen, Davis Ingram, Rohini Morey, Shadarra Crosby, Grace Mathew, Sheila Duncan, Cibelle F Lima, Jean-Yves Blay, Wolf Herman Fridman, Kenna Shaw, Ignacio Wistuba, Andrew Futreal, Nadim Ajami, Jennifer A Wargo, Neeta Somaiah

Faculty, Staff and Student Publications

Based on the demonstrated clinical activity of immune-checkpoint blockade (ICB) in advanced dedifferentiated liposarcoma (DDLPS) and undifferentiated pleomorphic sarcoma (UPS), we conducted a randomized, non-comparative phase 2 trial ( NCT03307616 ) of neoadjuvant nivolumab or nivolumab/ipilimumab in patients with resectable retroperitoneal DDLPS (n = 17) and extremity/truncal UPS (+ concurrent nivolumab/radiation therapy; n = 10). The primary end point of pathologic response (percent hyalinization) was a median of 8.8% in DDLPS and 89% in UPS. Secondary end points were the changes in immune infiltrate, radiographic response, 12- and 24-month relapse-free survival and overall survival. Lower densities of regulatory T cells …


Reliability Of Popliteal Artery Flow-Mediated Dilation In The Seated Position, Taskina Akhter Apr 2024

Reliability Of Popliteal Artery Flow-Mediated Dilation In The Seated Position, Taskina Akhter

Rehabilitation Sciences Theses & Dissertations

Flow-mediated dilation (FMD) is a noninvasive measurement of endothelial function, which is a useful prognostic tool for cardiovascular disease risk. Despite its widespread use since 1992, the reproducibility of FMD varies widely between studies. This variability in reproducibility is especially significant in the case of the popliteal artery due to different methodological approaches. Studies perform popliteal FMD in various body positions, with the prone and seated positions most common. However, no studies have examined the reproducibility of both the seated and prone positions of the popliteal artery FMD. Therefore, the aim of this study is to examine the test-retest and …


The Place Of Nuclear Weapons In Russian Identity: An Ontological Security Analysis, Peter Ernest Yeager Apr 2024

The Place Of Nuclear Weapons In Russian Identity: An Ontological Security Analysis, Peter Ernest Yeager

Graduate Program in International Studies Theses & Dissertations

On May 9, 2008, Russia’s Victory Day, four 14-wheeled MAZ-7917s drove through Red Square carrying Topol intercontinental ballistic missiles. This was the first time nuclear weapons had been paraded through Moscow since before the end of the Cold War. The previous August, Russia had resumed nuclear-capable bomber patrols, and in January, 2007, President Putin acknowledged Russia had begun to build new nuclear weapons. These remarkable events were met with little acknowledgement in the West, as if they were completely normal. Instead, they represented a major evolution in the bilateral relationship between the United States and Russia. Sixteen years of fitful …


Chromatin Remodeling In Patient-Derived Colorectal Cancer Models, Kun Xiang, Ergang Wang, John Mantyh, Gabrielle Rupprecht, Marcos Negrete, Golshid Sanati, Carolyn Hsu, Peggy Randon, Anders Dohlman, Kai Kretzschmar, Shree Bose, Nicholas Giroux, Shengli Ding, Lihua Wang, Jorge Prado Balcazar, Qiang Huang, Pasupathi Sundaramoorthy, Rui Xi, Shannon Jones Mccall, Zhaohui Wang, Chongming Jiang, Yubin Kang, Scott Kopetz, Gregory E Crawford, Steven M Lipkin, Xiao-Fan Wang, Hans Clevers, David Hsu, Xiling Shen Apr 2024

Chromatin Remodeling In Patient-Derived Colorectal Cancer Models, Kun Xiang, Ergang Wang, John Mantyh, Gabrielle Rupprecht, Marcos Negrete, Golshid Sanati, Carolyn Hsu, Peggy Randon, Anders Dohlman, Kai Kretzschmar, Shree Bose, Nicholas Giroux, Shengli Ding, Lihua Wang, Jorge Prado Balcazar, Qiang Huang, Pasupathi Sundaramoorthy, Rui Xi, Shannon Jones Mccall, Zhaohui Wang, Chongming Jiang, Yubin Kang, Scott Kopetz, Gregory E Crawford, Steven M Lipkin, Xiao-Fan Wang, Hans Clevers, David Hsu, Xiling Shen

Faculty, Staff and Student Publications

Patient-Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient-derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear. Herein, the transcriptomic and chromatin accessibility landscapes of matched colorectal cancer (CRC) PDO, PDX, PDO-derived PDX (PDOX), and original patient tumors (PT) are compared. Two major remodeling axes are discovered. The first axis delineates PDMC from PT, and the second axis distinguishes PDX and PDO. PDOX are more similar to PDX than PDO, indicating the growth environment is a driving force for chromatin adaptation. Transcription factors …


Performing Information Extraction For Mission Engineering Applications, Samuel R. Koski Apr 2024

Performing Information Extraction For Mission Engineering Applications, Samuel R. Koski

Engineering Management & Systems Engineering Theses & Dissertations

The process of extracting structured data from unstructured and semi-structured text is manual, time consuming and error prone. Current natural language processing approaches for automating this process are difficult to verify for non-trivial and context-sensitive corpora. Large Language Models (LLMs) like ChatGPT have become a subject of considerable interest, opening a promising avenue of exploration. However, there is limited evidence on the performance of LLMs for information extraction.

In this dissertation, an approach is proposed to evaluate the accuracy of Stanford OpenIE and OpenAI's ChatGPT for this purpose. This includes comparing Resource Description Framework (RDF) triples extracted by each of …


Preparing Nursing Students To Manage Acculturative Stress Experienced During Study Abroad Experiences: Novel Use Of Immersive Simulation And Cognitive Behavioral Strategies, Theresa Schnable, Christine A. Schindler, Jeffrey D. Roche, Karli Webster, Christopher E. Larkee, Maharaj Singh, John F. Ladisa Apr 2024

Preparing Nursing Students To Manage Acculturative Stress Experienced During Study Abroad Experiences: Novel Use Of Immersive Simulation And Cognitive Behavioral Strategies, Theresa Schnable, Christine A. Schindler, Jeffrey D. Roche, Karli Webster, Christopher E. Larkee, Maharaj Singh, John F. Ladisa

College of Nursing Faculty Research and Publications

This pilot study adds to the understanding of interventions to manage acculturative stress experienced during undergraduate study abroad programs. It was designed to evaluate the impact of cognitive behavioral strategy training combined with intentional practice during mixed reality (MR) simulations on acculturative stress. Participants included a convenience sample of undergraduate nursing students enrolled in a faculty-led study abroad course. Students participated in two MR simulations within a virtual environment over back-to-back days. Simulations were written by nursing faculty experts to reproduce realistic clinical situations students may encounter while studying in Peru. The Generalized Self-Efficacy Scale, State-Trait Anxiety Inventory, and Slater-Usoh-Steed …


Targetable Genetic Abnormalities In Patients With Acute Myeloblastic Leukemia Across Age Groups, Alex Bataller, Courtney D Dinardo, Alexandre Bazinet, Naval G Daver, Abhishek Maiti, Gautam Borthakur, Nicholas Short, Koji Sasaki, Elias J Jabbour, Ghayas C Issa, Naveen Pemmaraju, Musa Yilmaz, Guillermo Montalban-Bravo, Sanam Loghavi, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M Kantarjian, Tapan M Kadia Apr 2024

Targetable Genetic Abnormalities In Patients With Acute Myeloblastic Leukemia Across Age Groups, Alex Bataller, Courtney D Dinardo, Alexandre Bazinet, Naval G Daver, Abhishek Maiti, Gautam Borthakur, Nicholas Short, Koji Sasaki, Elias J Jabbour, Ghayas C Issa, Naveen Pemmaraju, Musa Yilmaz, Guillermo Montalban-Bravo, Sanam Loghavi, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M Kantarjian, Tapan M Kadia

Faculty, Staff and Student Publications

Incidence of potential targetable genetic abnormalities by age in AML.


So Much (For) Saving Rock And Roll: The Musical Dna Of Fall Out Boy, Blake Buehler Apr 2024

So Much (For) Saving Rock And Roll: The Musical Dna Of Fall Out Boy, Blake Buehler

Electronic Theses and Dissertations

Although the American rock band Fall Out Boy has had a great impact upon the popular music scene since their first album in 2003, little academic literature exists exploring their musical and cultural influences and impact. Through careful transcription and analysis this thesis defines Fall Out Boy’s compositional tendencies and contextualizes their work in the greater Western popular music canon. My composition, AQUA, is a continuation and response to Fall Out Boy’s seminal album, So Much (For) Stardust. Grounded in influences from Fall Out Boy’s music and my personal journey as a musician and queer individual, AQUA represents a deeply …


Abatacept Pharmacokinetics And Exposure Response In Patients Hospitalized With Covid-19: A Secondary Analysis Of The Activ-1 Im Randomized Clinical Trial, Stephen J Balevic, Daniel K Benjamin, William G Powderly, P Brian Smith, Daniel Gonzalez, Matthew W Mccarthy, Linda K Shaw, Christopher J Lindsell, Sam Bozzette, Daphne Williams, Benjamin P Linas, John Blamoun, Heta Javeri, Christoph P Hornik, Activ-1 Im Study Group Apr 2024

Abatacept Pharmacokinetics And Exposure Response In Patients Hospitalized With Covid-19: A Secondary Analysis Of The Activ-1 Im Randomized Clinical Trial, Stephen J Balevic, Daniel K Benjamin, William G Powderly, P Brian Smith, Daniel Gonzalez, Matthew W Mccarthy, Linda K Shaw, Christopher J Lindsell, Sam Bozzette, Daphne Williams, Benjamin P Linas, John Blamoun, Heta Javeri, Christoph P Hornik, Activ-1 Im Study Group

2020-Current year OA Pubs

IMPORTANCE: The pharmacokinetics of abatacept and the association between abatacept exposure and outcomes in patients with severe COVID-19 are unknown.

OBJECTIVE: To characterize abatacept pharmacokinetics, relate drug exposure with clinical outcomes, and evaluate the need for dosage adjustments.

DESIGN, SETTING, AND PARTICIPANTS: This study is a secondary analysis of data from the ACTIV-1 (Accelerating COVID-19 Therapeutic Interventions and Vaccines) Immune Modulator (IM) randomized clinical trial conducted between October 16, 2020, and December 31, 2021. The trial included hospitalized adults who received abatacept in addition to standard of care for treatment of COVID-19 pneumonia. Data analysis was performed between September 2022 …


Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-To-Neuron Transmission, Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, Shu Zhang, Lingtao Jin, Creg J Workman, Dario A A Vignali, Olga Pletinkova, Hongpeng Jia, Weiyi Peng, David W Nauen, Philip C Wong, Javier Redding-Ochoa, Juan C Troncoso, Mingyao Ying, Valina L Dawson, Ted M Dawson, Xiaobo Mao Apr 2024

Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-To-Neuron Transmission, Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, Shu Zhang, Lingtao Jin, Creg J Workman, Dario A A Vignali, Olga Pletinkova, Hongpeng Jia, Weiyi Peng, David W Nauen, Philip C Wong, Javier Redding-Ochoa, Juan C Troncoso, Mingyao Ying, Valina L Dawson, Ted M Dawson, Xiaobo Mao

Faculty, Staff and Student Publications

The spread of prion-like protein aggregates is a common driver of pathogenesis in various neurodegenerative diseases, including Alzheimer's disease (AD) and related Tauopathies. Tau pathologies exhibit a clear progressive spreading pattern that correlates with disease severity. Clinical observation combined with complementary experimental studies has shown that Tau preformed fibrils (PFF) are prion-like seeds that propagate pathology by entering cells and templating misfolding and aggregation of endogenous Tau. While several cell surface receptors of Tau are known, they are not specific to the fibrillar form of Tau. Moreover, the underlying cellular mechanisms of Tau PFF spreading remain poorly understood. Here, it …


Engagement With Radical Propaganda Drives Cognitive Radicalization: An Analysis Of A Right-Wing Online Ecosystem, Julius B. Calvert Apr 2024

Engagement With Radical Propaganda Drives Cognitive Radicalization: An Analysis Of A Right-Wing Online Ecosystem, Julius B. Calvert

Journal of Strategic Security

Cognitive radicalization remains an issue for communities battling terrorism. Recent empirical investigations into the psycho-social processes involved with radicalization have revealed social exclusion, cognitive inflexibility, and perceived threats to an ingroup as significant predictors for one’s propensity to engage with radical content and commit to offline behaviors. This study investigates the utility of user engagement and the proxy effect on cognitive radicalization by examining users’ engagement with a radical-right online ecosystem. The study supported the assumption that content featuring outgroup prejudice would affect the cognitive radicalization process. Several results demonstrate the importance of user engagement in the process of radicalization. …


The Palestinian Divide: Origins And Implications Of Palestinian Rejectionism, Martin S. Widzer Apr 2024

The Palestinian Divide: Origins And Implications Of Palestinian Rejectionism, Martin S. Widzer

Journal of Strategic Security

In what is likely to amount to nothing more than a pyrrhic victory, Hamas’ October 2023 infiltration into Israel and subsequent assault will be greeted as a heroic act of resistance in some sectors of Palestinian society. It will invoke dread and anger in others. Employing a genealogical approach, this paper explores the effects of sectarian infighting over ideology, tactics, and aims as a means to garner greater in-group support. In doing so, the paper demonstrates that it is not so much Israel that is the object of the Palestinian struggle, but rather the struggle between the Palestinian factions themselves.



Military History For The Modern Strategist: America’S Major Wars Since 1861. By Michael O’Hanlon. Washington, Dc: Brookings Institution Press, 2023, Amos C. Fox Apr 2024

Military History For The Modern Strategist: America’S Major Wars Since 1861. By Michael O’Hanlon. Washington, Dc: Brookings Institution Press, 2023, Amos C. Fox

Journal of Strategic Security

No abstract provided.


A Threshold Assessment: Is Technology Among The Competencies Tested By The Mpre?, Amy A. Emerson Apr 2024

A Threshold Assessment: Is Technology Among The Competencies Tested By The Mpre?, Amy A. Emerson

Faculty Publications

No abstract provided.


Illinois State University Annuitants Association Newsletter, Spring 2024, Illinois State University, Annuitants Association Apr 2024

Illinois State University Annuitants Association Newsletter, Spring 2024, Illinois State University, Annuitants Association

ISUAA News

Illinois State University Annuitants Association newsletter


Low-Dimensional Criticality Embedded In High-Dimensional Awake Brain Dynamics, Antonio J. Fontenele, J. Samuel Sooter, V. Kindler Norman, Shree Hari Gautam, Woodrow L. Shew Apr 2024

Low-Dimensional Criticality Embedded In High-Dimensional Awake Brain Dynamics, Antonio J. Fontenele, J. Samuel Sooter, V. Kindler Norman, Shree Hari Gautam, Woodrow L. Shew

Physics Faculty Publications and Presentations

Whether cortical neurons operate in a strongly or weakly correlated dynamical regime determines fundamental information processing capabilities and has fueled decades of debate. We offer a resolution of this debate; we show that two important dynamical regimes, typically considered incompatible, can coexist in the same local cortical circuit by separating them into two different subspaces. In awake mouse motor cortex, we find a low-dimensional subspace with large fluctuations consistent with criticality—a dynamical regime with moderate correlations and multi-scale information capacity and transmission. Orthogonal to this critical subspace, we find a high-dimensional subspace containing a desynchronized dynamical regime, which may optimize …


Digital Footprints: Technology, Race, And Justice, Cassandra Jones Havard Apr 2024

Digital Footprints: Technology, Race, And Justice, Cassandra Jones Havard

Cardozo Law Review

Data aggregation is ubiquitous. To widen credit access, lenders now use nonconventional sources of personal technological information to measure borrower creditworthiness. Alternative data credit scoring is touted as a useful solution for borrowers with little or no credit history or “thin credit files.” The supposedly neutral algorithm provides a predictive analysis of the borrower’s ability to repay, thus allowing the borrower to obtain credit within the formal banking network.

Alternative data has the potential to expand access to financial services for underserved populations and make credit markets more competitive. Machine learning, or predictive behavioral analytics, collects and sorts the borrower’s …


All For One, One For None: Arrington V. Burger King Worldwide And The Single-Entity Defense For Franchises, Tyler Nappo Apr 2024

All For One, One For None: Arrington V. Burger King Worldwide And The Single-Entity Defense For Franchises, Tyler Nappo

Cardozo Law Review

Section 1 of the Sherman Antitrust Act (Sherman § 1) proclaims contracts, combinations, or conspiracies in restraint of trade or commerce to be illegal. Thus, for an agreement to fall within Sherman § 1’s boundaries, there must be a joining together of separate actors or entities. However, for over a century since the Sherman Act’s enactment, courts have struggled to draw the line between separate business entities and single entities. This distinction became more defined with the Supreme Court’s holding in Copperweld Corp. v. Independence Tube Corp. that parent companies are incapable of conspiring with wholly owned subsidiaries. But Copperweld …


Reliability And Validity Of Smartphone Cognitive Testing For Frontotemporal Lobar Degeneration, Adam M Staffaroni, Nupur Ghoshal, Jason Hassenstab, Et Al. Apr 2024

Reliability And Validity Of Smartphone Cognitive Testing For Frontotemporal Lobar Degeneration, Adam M Staffaroni, Nupur Ghoshal, Jason Hassenstab, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Frontotemporal lobar degeneration (FTLD) is relatively rare, behavioral and motor symptoms increase travel burden, and standard neuropsychological tests are not sensitive to early-stage disease. Remote smartphone-based cognitive assessments could mitigate these barriers to trial recruitment and success, but no such tools are validated for FTLD.

OBJECTIVE: To evaluate the reliability and validity of smartphone-based cognitive measures for remote FTLD evaluations.

DESIGN, SETTING, AND PARTICIPANTS: In this cohort study conducted from January 10, 2019, to July 31, 2023, controls and participants with FTLD performed smartphone application (app)-based executive functioning tasks and an associative memory task 3 times over 2 weeks. …