Digital Commons Network^™

Fraud In Genetic Testing: Swindling The System, Rachel Notestine, Rachel Notestine, Claire N. Singletary

Dissertations and Theses (Open Access)

Healthcare fraud comprises a sizable portion of the United States healthcare expenditure and inflicts strain on payors, patients, and the healthcare system overall. The genetic testing industry is rapidly growing which provides a multitude of fraud opportunities. There is limited research exploring genetic testing fraud, although federal organizations have highlighted it as an issue. In this study, a retrospective review of federal websites, news articles, and a legal database identified 42 cases of fraud involving outpatient genetic testing published between February 2019 and December 2023. These cases were analyzed for themes via inductive conventional content analysis. Themes of fraudulent activity …

Methods For The Prediction Of Osteoradionecrosis Resulting From Head And Neck Cancer Radiation Therapy, Brandon Reber

Dissertations and Theses (Open Access)

Head and neck cancer (HNC) is the sixth most diagnosed cancer worldwide with over 600,000 patients diagnosed every year. One of the primary methods to treat HNC is through radiation therapy (RT). While RT is effective at treating HNC, late toxicities resulting from treatment can occur months to years post-treatment and can cause debilitating quality of life changes for HNC survivors. One of these late toxicities is osteoradionecrosis (ORN), which is the death of bone due to radiation. For HNC, the mandible is commonly affected and can cause challenges chewing, swallowing, and physical appearance changes. Several factors indicate the pressing …

Retinoid X Receptor As A Mediator Of Post Stroke Recovery By Reversing Age-Associated Phenotypes Of Microglia/Macrophages, Shun-Ming Ting

Dissertations and Theses (Open Access)

After stroke, microglia (MG) and blood-derived macrophages, together (MF), clear dead cells and cellular debris in the infarcted brain through phagocytosis. However, the phagocytic capability of MF declines with age. Age-related changes in MF phenotype also include overactive inflammatory responses to stroke-induced brain injury, altogether resulting in poor recovery after stroke. Retinoid-X-receptor (RXR) is a pleiotropic transcription factor. Our studies suggest that RXRa enhances MF phagocytic functions, reduces inflammatory responses, and improves post-stroke recovery. To establish phenotypes of aging MF, MG were MACS-sorted from the brains of young adults (2-4 months old) and aged (18-20 months old) mice for transcriptomic …

Motivations And Attitudes For Pursuing Anonymous Genetic Testing For Huntington’S Disease, Jordan Steffen

Dissertations and Theses (Open Access)

Huntington’s disease (HD) is a progressive neurodegenerative disorder for which predictive and confirmatory testing is available. However, only a small portion of at-risk individuals complete predictive testing. Concerns of privacy and genetic discrimination have been cited as reasons testing is declined. This leads some to seek anonymous testing, a process in which measures are taken to exclude identifying information, thereby preventing results from being linked to legal names, medical records, or health insurance. Previous research suggests anonymous testing is not widely favored amongst healthcare providers, but patient perspectives have not been described. These studies also precede the implementation of the …

Structural And Functional Studies Of Ascc1 In Dna And Rna Alkylation Damage Response, Naga Babu Chinnam

Dissertations and Theses (Open Access)

Alkylating agents from environmental, endogenous, and certain chemotherapeutic sources constantly challenge cellular nucleic acids. Repairing the damage caused by alkylation is necessary for maintaining genomic stability. ALKB family Human Homolog ALKBH3 plays a key in repairing alkylated damages in DNA and RNA molecules. Activating signal co-integrator complex 1 (ASCC1) acts with ASCC-ALKBH3 complex in alkylation damage responses. ASCC1 uniquely combines two evolutionarily ancient domains: nucleotide-binding K-Homology (KH) (associated with splicing, transcriptional regulation, and translational control) and two-histidine phosphodiesterase (PDE) (associated with hydrolysis of cyclic nucleotide phosphate bonds). Germline mutations link ASCC1 loss of function to spinal muscular atrophy with congenital …

Ai-Proof Your Assignments, Sarah Vital

Staff Works

No abstract provided.

Using Pre-Trained Models For Vision-Language Understanding Tasks, Rui Cao

Dissertations and Theses Collection (Open Access)

In recent years, remarkable progress has been made in Artificial Intelligence (AI), with an increasing focus on integrating AI systems into people’s daily lives. In the context of our diverse world, research attention has shifted towards applying AI to multimodal understanding tasks. This thesis specifically addresses two key modalities, namely, vision and language, and explores Vision-Language Understanding (VLU).

In the past, addressing VLU tasks involved training distinct models from scratch using task-specific data. However, limited by the amount of training data, models may easily overfit the training data and fail to generalize. A recent breakthrough is the development of Pre-trained …

A Reinforcement Learning Framework For Powertrain Control Including Shared Learning Among A Fleet Of Vehicles, Lindsey Kerbel

All Dissertations

The transportation sector provides a significant opportunity to reduce global emissions, both through technological advancements and vehicular control strategies. Model-based control systems are popular methods for increasing the operating efficiency of vehicles. However, these systems often rely on models that require costly calibrations that still fail to capture the complexity of modern powertrain systems and the variations found in real-world driving. The recent availability of operational data through connected vehicle technology and/or edge devices has led to the emergence of data-driven control strategies that can learn optimal control policies through the interactions of the vehicle’s control system with the environment. …

Optical Wavelength Measurement Based On Microwave-Photonics And Fiber Dispersion, Yongji Wu

All Dissertations

In modern photonics, combining microwave techniques with optical measurements has introduced a novel research direction. This study introduces a novel Microwave Photonics Wavelength Measurement System (MP-WMS), integrating microwave photonics with fiber chromatic dispersion to achieve direct wavelength measurement. Utilizing cost effective single mode optical fibers as dispersion devices, this system employs chromatic dispersion to convert optical frequency domain measurements into microwave time domain measurements. We established a mathematical model to describe how different wavelengths are detected, enhancing the system's effectiveness. The MP-WMS system offers an affordable solution with high resolution. In the experiment, we used a 35km long SM-28 single-mode …

A Mixed Methods Study Of South Carolina Reading Policy On Teacher Knowledge, Matthew Ferguson

All Dissertations

This sequential explanatory mixed methods study examines the impact of the Language Essentials for Teachers of Reading and Spelling (LETRS) professional learning intervention on teacher knowledge within the context of South Carolina's reading policy.

Quantitative analyses of pre- and post-assessment data indicate significant improvements in teacher content knowledge of foundational literacy skills following LETRS training. Descriptive statistics and paired-samples t-tests demonstrate substantial gains in knowledge, particularly in Volume 1 of the LETRS curriculum. The study reveals notable increases in pre- and post-assessment scores, suggesting the effectiveness of LETRS in enhancing teacher expertise.

Qualitative findings from focus groups highlight the positive …

Single Cell Pharmacodynamic Modeling Of Cancer Cell Lines, Arnab Mutsuddy

All Dissertations

Cancer is one of the leading causes of disease related death worldwide. Since the discovery of the genomic origins of cancer, targeted therapy has been developed towards specific mutations implicated for oncogenic transformation. However, current standard-of-care for mapping cancer patients to efficacious drug combination is often inadequate. The pathophysiology of tumor progression relies on the dysregulation of biomolecular pathways of which the topology and the dynamics challenge prognosis. Moreover, the overall genomic instability involved in disease states and the resulting inter-patient as well as intra-tumoral heterogeneity challenge rationalization of therapy and clinical decision-making. It highlights the need for the use …

Study Of Electrospun Nanocomposite Nanofiber Nonwoven Mats With Precursor Solutions Prepared By Ultrasonic Processing, Stephanie Tussey

All Dissertations

Understanding the complexity of changes in a polymer solution through the addition of nanoparticles and the process used to prepare the solutions is vitally important to obtain desirable characteristics of electrospun nanofibers such as degree of crystallinity, morphological, thermal and mechanical properties. Although there have been significant efforts in this research area, a more in-depth understanding on how nanoparticles can affect the formation of polymeric structures during electrospinning is still needed to ensure overall quality and performance of the nonwoven material. The present study aimed to specifically explore the relationship between solution processing method, nanoparticle volume fraction, and solution properties …

A Rhetorical-Sociological Understanding Of Emotion, Amy Boone

All Dissertations

This project presents a rhetorical-sociological understanding of emotion while foregrounding the place and role of language. Born from Sara Ahmed’s work in The Cultural Politics of Emotion, it presents a simplified equation (contact + orientation = emotion) as both a prescriptive and descriptive formula for making sense of human emotional experience. Starting with an exploration of the difficult-to-understand affect system, this dissertation identifies both rhetoric and affect as energies which cannot be understood apart from their traces, the things they move, produce, and become. As a way to get at these often-invisible forces, two trace studies are conducted which explore …

Exploring Novel Nutrient Acquisition Mechanisms For Maintaining Energy Metabolism In Toxoplasma Gondii, Melanie Key

All Dissertations

Toxoplasma gondii is an infectious intracellular parasite that establishes infection within various mammalian hosts, including humans. Toxoplasma infects approximately one-third of the global population, making it an impactful pathogen of study. T. gondii is the causative agent of toxoplasmosis, an opportunistic infection that causes severe illness or fatality in immunocompromised individuals or pregnant women. The parasite possesses a very effective invasion strategy, allowing it to cross different tissue types to disseminate infection across the placental and blood-brain barrier. Although there are a few treatments for acute toxoplasmosis, these drugs can produce adverse side effects. These options are not effective against …

Machine Learning Assisted Discovery Of High-Performance Perovskites For Hydrogen Production, Ximei Zhai

All Dissertations

Hydrogen has significantly contributed to the global energy transition as a clean energy carrier. However, traditional hydrogen production involves energy-intensive processes with heavy carbon emissions. High-temperature water splitting to generate hydrogen has become a promising route for clean hydrogen production. Directly utilizing concentrated solar heat to perform solar thermochemical hydrogen (STCH) production is considered one of the most eco-friendly hydrogen production options. At the same time, high-temperature electrolysis in protonic ceramic electrolysis cells (PCECs) can efficiently utilize intermittent and cost-effective renewable electricity to produce hydrogen. Perovskite oxides with good redox capability and tolerance for oxygen deficiency are considered the most …

Can I Get A Witness? Employee Reactions To Witnessing Visible Self-Compassion At Work, Sara Krivacek

All Dissertations

Self-compassion is defined as a tripartite process whereby an individual notices their own suffering, feels empathetic concern for oneself, and responds to alleviate or address the suffering. Research on self-compassion has proliferated in the last decade, and a major theme in the literature posits that it is beneficial for the practicing individual. However, less attention is given to the impact of self-compassion expression on other individuals in the workplace – partly because one major assumption is that self-compassion is an internalized process. In this dissertation, I conceptualize self-compassion as a social process and draw from affective events theory to make …

Experiences Of Vertical Transfer Students In The Department Of Biological Sciences With The Transfer Credit Process: A Phenomenological Study, Laura Love

All Dissertations

The purpose of this interpretive phenomenological study was to highlight the experiences of undergraduate STEM vertical transfer students. Through the lens of Schlossberg’s Transition Theory, this study sought to better understand how students make sense of the transfer credit process and which support structures facilitated their understanding. Semi-structured interviews were conducted using qualitative methods with eight biological sciences and vertical transfer students currently enrolled at a large public four-year land-grant research institution in the Southeast United States. All participants had successfully transferred from one of 16 technical colleges within the state. Using interpretative phenomenological analysis, three themes were identified. This …

Communication Of Oncology Genomics: Patients, Providers, And Artificial Intelligence, Lisa Stewart

All Dissertations

ABSTRACT This dissertation comprises five chapters concentrated on the communication of molecular profiling (MP) results between patients with cancer and oncology providers. Chapter I introduces MP and describes the significance of this testing. Chapter II is a state-of-the-art literature review focused on cancer patients’ expectations, knowledge, attitudes, satisfaction, and concerns regarding MP. Nineteen articles were reviewed, and findings revealed gaps in the communication process between patients and clinicians. Chapter III is a case study entitled “A Case for Caution: Patient Use of Artificial Intelligence.” In this case, pitfalls become apparent when a patient utilizes an artificial intelligence (AI) chatbot as …

Assessing Consumer Willingness To Pay For Zinc-Biofortified Rice – The Case Of Colombia, Sara Ann Oswalt

Graduate Theses and Dissertations

Hidden hunger, a form of undernourishment caused by micronutrient deficiencies, remains a critical global challenge affecting billions worldwide. Biofortification of staple crops, such as rice, offers a promising solution to address this problem. However, changes in the physical and culinary characteristics due to biofortification may hinder consumer acceptance and limit the benefits of this approach. This research explores consumer preferences and willingness to pay (WTP) for zinc-biofortified rice in Cartagena, Colombia. A non-hypothetical experimental auction, including 400 consumers in five different locations within Cartagena, was conducted to analyze the impact of information, socioeconomic factors, and consumer nutrition knowledge on WTP …

Navigating Uncertainty In Tax Strategy Surrounding The Tax Cuts And Jobs Act Sunset, Tate Smith

Undergraduate Honors Capstone Projects

Throughout history, taxpayers have relied on tax strategies to reduce the proportion of income that is deemed taxable by the government. Today's tax environment is no exception, and with the changes surrounding the Tax Cuts and Jobs Act (TCJA) Sunset, taxpayers need to prepare their tax plans. In 2025, much of the current tax legislation for individual taxpayers will potentially revert to the pre-TCJA legislation. Preparing a strategy during this time period will be difficult because when the current legislation sunsets in 2025 many of the legislation changes will depend on which political party controls the presidency.

This paper seeks …

Creating An Evaluation Instrument For Governing Board Chairs At Institutions Of Higher Education, Kristi Shackelford

Dissertations, 2020-current

The goal of this mixed methods study was to design an instrument that evaluates the board chair of an institution of higher education’s governing board chair using criteria identified by current and former board members as contributing most to their perceived success as a leader, according to fellow board members. The assessment would provide feedback on the work of the board chair, providing a metric for accountability and guidance for continuous improvement.

The study uses a three-phase exploratory sequential design, using social construction as a theoretical framework. Qualitative data was collected through a literature review and semi-structured expert interviews, then …

The Impact Of A Pgym Variant On Myophosphorylase Deficiency In Red Angus Composite Cattle And Changes In The Skeletal Muscle Transcriptome Due To The Intramuscular Administration Of Lidocaine In Wether Lambs, Mackenzie Christin Batt

School of Biological Sciences: Dissertations, Theses, and Student Research

Project 1 focused on eight calves in a Nebraska herd (composite Simmental, Red Angus, Gelbvieh) that displayed exercise intolerance during forced activity. Available sire pedigrees contained a paternal ancestor within 2-4 generations in all affected calves. Pedigrees of the calves’ dams were unavailable, however, the cows were ranch-raised and retained from prior breeding seasons, where bulls used for breeding occasionally had a common ancestor. Therefore, it was hypothesized that a de novo autosomal recessive variant was causative of exercise intolerance in these calves. A genome-wide association analysis followed by whole-genome sequencing led to the identification of a variant in the …

Constitutional Rights And Remedial Consistency, Katherine Mims Crocker

Faculty Publications

When the Supreme Court declined definitively to block Texas’s S.B. 8, which effectively eliminated pre-enforcement federal remedies for what was then a plainly unconstitutional restriction on abortion rights, a prominent criticism was that the majority would have never tolerated the similar treatment of preferred legal protections—like gun rights. This refrain reemerged when California enacted a copycat regime for firearms regulation. This theme sounds in the deep-rooted idea that judge-made law should adhere to generality and neutrality values requiring doctrines to derive justification from controlling a meaningful class of cases ascertained by objective legal criteria.

This Article is about consistency, and …

The Banality Of Thinking: The Criticism Of Hannah Arendt’S "Eichmann In Jerusalem", J. Lynne Nelson

History Honors Theses

No abstract provided.

Rock-Paper-Scissors Robot, Cora Lewis, Zachary Moyer, Aakriti Acharya, Reece Colson

Mechatronics Final Projects

The design incorporates a sophisticated Rock Paper Scissors (RPS) playing interface, amalgamating robotics, audio control, gesture recognition, and display functionalities. At its core, the system employs a robotic hand mechanism featuring pulleys and fishing wire to simulate finger movements. This mechanism is orchestrated by servo motors through a PIC system, which receives commands from the Arduino. The Arduino serves as the central processor and begins a round when the player hits the reset button. It triggers an audio prompt at the onset of each round using an Icstation Recordable Sound Module, prompting the player to make their move. The Arduino …

Temperature Controlled Box, Dennis Butts, Gabriel Alford, John Hawes, Holden Soderstrom

Mechatronics Final Projects

The temperature-controlled box is a project developed in the Spring of 2024. Its main goal is to maintain a setpoint temperature by switching both a heating element on for heating and a fan on for cooling.

Geochemical Mechanisms Of Trace Element Mobilization And Attenuation In A Crude-Oil Contaminated Aquifer, Audrey Madison Davis

Earth and Environmental Geosciences Student Honors Theses

No abstract provided.

Where Silicone Meets Silicon: Analyzing Nier: Automata As A Subversive Postfeminist Text With Respect To Marxism, Existentialism And Feminism, Joaquin Vela

Communication Honors Theses

No abstract provided.

An Examination Of The Fitsparation Principles Of Influence, Anita Faerchuk

Masters Theses, 2020-current

Obesity is a health issue that continues to get worse. A contributing factor to this health issue is various marketing techniques that have made it harder for an individual to understand health information. This study was designed to help understand these tactics and how one can be armed against these marketing techniques as well as use them to help influence themselves and others to be healthy.

P300 Event-Related Potential Responses To Self-Relevant Stimuli, Jordan Razzak

Electronic Theses and Dissertations

Previous literature has suggested an apparent P300 sensitivity to self-relevant stimuli. To further explore this relationship, we asked participants to submit 10 photos, each of a particular category (e.g. footwear, plants), to be used as either targets or distractors in a given condition of an oddball task. Furthermore, we attempted to see whether the effect of self-relevance on the P300 could be induced in a participant by allowing them to study a set of unique photos which would then be used as targets. Our analysis suggested that P300 amplitude elicited in response to self-relevant stimuli used as targets was statistically …