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Higher Education Faculty Perceptions Of Soft Skill Gaps In Components Of Emotional Intelligence Among Recent Community College Graduates, Bryce Timothy Wiley May 2024

Higher Education Faculty Perceptions Of Soft Skill Gaps In Components Of Emotional Intelligence Among Recent Community College Graduates, Bryce Timothy Wiley

Walden Dissertations and Doctoral Studies

The problem addressed by this basic qualitative study was that recent college graduates may lack the soft skills needed for success in the job market. This gap may cause graduates to lack the skills required for employability. The purpose of this qualitative study was to explore faculty perceptions of soft skill gaps in components of emotional intelligence—self-awareness, self-regulation, motivation, empathy, and social skills—among recent college graduates. The study was conceptualized through the lens of Goleman’s emotional intelligence theoretical framework. Research questions asked college faculty about their views of soft skill deficits among recent college graduates in self-awareness, self-regulation, motivation, empathy, …


Perceptions Of Developmental Disability Service Providers, On How The Judicial System Responses To Persons With Developmental Disabilities., Donna Whilby May 2024

Perceptions Of Developmental Disability Service Providers, On How The Judicial System Responses To Persons With Developmental Disabilities., Donna Whilby

Walden Dissertations and Doctoral Studies

The situation or issue that prompted me to search the literature was observing the persons with developmental disabilities circling the judicial system due to multiple encounters with law enforcement. The purpose of this qualitative study was to understand how the Northeast Florida judicial system could improve the outcomes of persons with developmental disabilities by reducing and preventing multiple encounters. The empowerment theory was the most appropriate theory for my study. Empowerment theory indicates that it is imperative to encourage people, especially those who have a psychological deficit, to lean into their resources to gain and utilize their power in society. …


Collective Order And Group Structure Of Shoaling Fish Subject To Differing Risk-Level Treatments With A Sympatric Predator, Timothy M. Schaerf, Alexander D.M. Wilson, Mitchell Welch, Ashley J.W. Ward May 2024

Collective Order And Group Structure Of Shoaling Fish Subject To Differing Risk-Level Treatments With A Sympatric Predator, Timothy M. Schaerf, Alexander D.M. Wilson, Mitchell Welch, Ashley J.W. Ward

School of Biological and Marine Sciences

It is imperative for individuals to exhibit flexible behaviour according to ecological context, such as available resources or predation threat. Manipulative studies on responses to threat often focus on behaviour in the presence of a single indicator for the potential of predation, whereas in the wild perception of threat will probably be more nuanced. Here, we examine the collective behaviour of eastern mosquitofish (Gambusia holbrooki) subject to five differing threat scenarios relating to the presence and hunger state of a jade perch (Scortum barcoo). Across threat scenarios, groups exhibit unique behavioural profiles that differ in the durations that particular collective …


Jag1/2 Maintain Esophageal Homeostasis And Suppress Foregut Tumorigenesis By Restricting The Basal Progenitor Cell Pool, Haidi Huang, Yu Jiang, Jiangying Liu, Dan Luo, Jianghong Yuan, Rongzi Mu, Xiang Yu, Donglei Sun, Jihong Lin, Qiyue Chen, Xinjing Li, Ming Jiang, Jianming Xu, Bo Chu, Chengqian Yin, Lei Zhang, Youqiong Ye, Bo Cao, Qiong Wang, Yongchun Zhang May 2024

Jag1/2 Maintain Esophageal Homeostasis And Suppress Foregut Tumorigenesis By Restricting The Basal Progenitor Cell Pool, Haidi Huang, Yu Jiang, Jiangying Liu, Dan Luo, Jianghong Yuan, Rongzi Mu, Xiang Yu, Donglei Sun, Jihong Lin, Qiyue Chen, Xinjing Li, Ming Jiang, Jianming Xu, Bo Chu, Chengqian Yin, Lei Zhang, Youqiong Ye, Bo Cao, Qiong Wang, Yongchun Zhang

Faculty, Staff and Students Publications

Basal progenitor cells are crucial for maintaining foregut (the esophagus and forestomach) homeostasis. When their function is dysregulated, it can promote inflammation and tumorigenesis. However, the mechanisms underlying these processes remain largely unclear. Here, we employ genetic mouse models to reveal that Jag1/2 regulate esophageal homeostasis and foregut tumorigenesis by modulating the function of basal progenitor cells. Deletion of Jag1/2 in mice disrupts esophageal and forestomach epithelial homeostasis. Mechanistically, Jag1/2 deficiency impairs activation of Notch signaling, leading to reduced squamous epithelial differentiation and expansion of basal progenitor cells. Moreover, Jag1/2 deficiency exacerbates the deoxycholic acid (DCA)-induced squamous epithelial injury and …


Optical Coherence Tomography-Guided Brillouin Microscopy Highlights Regional Tissue Stiffness Differences During Anterior Neural Tube Closure In The Mthfd1l Murine Mutant, Yogeshwari S Ambekar, Carlo Donato Caiaffa, Bogdan J Wlodarczyk, Manmohan Singh, Alexander W Schill, John W Steele, Jitao Zhang, Salavat R Aglyamov, Giuliano Scarcelli, Richard H Finnell, Kirill V Larin May 2024

Optical Coherence Tomography-Guided Brillouin Microscopy Highlights Regional Tissue Stiffness Differences During Anterior Neural Tube Closure In The Mthfd1l Murine Mutant, Yogeshwari S Ambekar, Carlo Donato Caiaffa, Bogdan J Wlodarczyk, Manmohan Singh, Alexander W Schill, John W Steele, Jitao Zhang, Salavat R Aglyamov, Giuliano Scarcelli, Richard H Finnell, Kirill V Larin

Faculty, Staff and Students Publications

Neurulation is a highly synchronized biomechanical process leading to the formation of the brain and spinal cord, and its failure leads to neural tube defects (NTDs). Although we are rapidly learning the genetic mechanisms underlying NTDs, the biomechanical aspects are largely unknown. To understand the correlation between NTDs and tissue stiffness during neural tube closure (NTC), we imaged an NTD murine model using optical coherence tomography (OCT), Brillouin microscopy and confocal fluorescence microscopy. Here, we associate structural information from OCT with local stiffness from the Brillouin signal of embryos undergoing neurulation. The stiffness of neuroepithelial tissues in Mthfd1l null embryos …


Optical Coherence Tomography-Guided Brillouin Microscopy Highlights Regional Tissue Stiffness Differences During Anterior Neural Tube Closure In The Mthfd1l Murine Mutant, Yogeshwari S Ambekar, Carlo Donato Caiaffa, Bogdan J Wlodarczyk, Manmohan Singh, Alexander W Schill, John W Steele, Jitao Zhang, Salavat R Aglyamov, Giuliano Scarcelli, Richard H Finnell, Kirill V Larin May 2024

Optical Coherence Tomography-Guided Brillouin Microscopy Highlights Regional Tissue Stiffness Differences During Anterior Neural Tube Closure In The Mthfd1l Murine Mutant, Yogeshwari S Ambekar, Carlo Donato Caiaffa, Bogdan J Wlodarczyk, Manmohan Singh, Alexander W Schill, John W Steele, Jitao Zhang, Salavat R Aglyamov, Giuliano Scarcelli, Richard H Finnell, Kirill V Larin

Faculty, Staff and Students Publications

Neurulation is a highly synchronized biomechanical process leading to the formation of the brain and spinal cord, and its failure leads to neural tube defects (NTDs). Although we are rapidly learning the genetic mechanisms underlying NTDs, the biomechanical aspects are largely unknown. To understand the correlation between NTDs and tissue stiffness during neural tube closure (NTC), we imaged an NTD murine model using optical coherence tomography (OCT), Brillouin microscopy and confocal fluorescence microscopy. Here, we associate structural information from OCT with local stiffness from the Brillouin signal of embryos undergoing neurulation. The stiffness of neuroepithelial tissues in Mthfd1l null embryos …


Give Penicillin Or Ceftriaxone: Neurosyphilis Does Not Deal In Absolutes, Nicolás W Cortés-Penfield, Daniel M Musher May 2024

Give Penicillin Or Ceftriaxone: Neurosyphilis Does Not Deal In Absolutes, Nicolás W Cortés-Penfield, Daniel M Musher

Faculty, Staff and Students Publications

No abstract provided.


K(Now) W(Here), Yulin Yuan May 2024

K(Now) W(Here), Yulin Yuan

Masters Theses, 2020-current

“How does one discover solace and belonging within these layered narratives?”

In mythology, narratives were once created to answer the incomprehensible questions of an era. These narratives unveil half-truths, customs, and convictions. K(now) W(here) is based on the experience of the artist who is Chinese and immigrated to South Africa at a young age; she elaborates the story about assimilation, authenticity, tales of her ancestral roots, and, most often, myths of identity.

The artist used narratives from Chinese mythology, collaged physically and metaphorically using tangible objects from other’s homes in combination with photography, digital media, and domestic items and assemblage …


Courthouse Doors Are Closed To Foreign Citizens For International Law Torts Committed By American Corporations, Gisell Landrian May 2024

Courthouse Doors Are Closed To Foreign Citizens For International Law Torts Committed By American Corporations, Gisell Landrian

University of Miami Inter-American Law Review

This Note examines the intersection of corporate accountability, human rights violations, and legal recourse for victims of child slavery in the cocoa industry inspired by the Court’s decision Nestle USA, Inc. v. Doe. This decision further limited the scope of the Alien Tort Statute, hindering the plaintiffs’ quest for justice for international human rights violations. The Note analyzes the decision in Nestle USA, Inc. v. Doe through (1) an examination of the Court’s limitations on the Alien Tort Statute and (2) an analysis of the Canadian Supreme Court’s decision in Nevsun.


Re: Approval Of The Revised Draft Final Silver Bow Creek Conservation Area Repository Data Gap Quality Assurance Project Plan (Qapp) (Dated 5/7/24), Emma Rott May 2024

Re: Approval Of The Revised Draft Final Silver Bow Creek Conservation Area Repository Data Gap Quality Assurance Project Plan (Qapp) (Dated 5/7/24), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


2024-05-15 Spring Carnival Brings An Abundance Of Shaved Ice And Prizes, George Burquest May 2024

2024-05-15 Spring Carnival Brings An Abundance Of Shaved Ice And Prizes, George Burquest

The Spectator Online

No abstract provided.


College Students’ Domestic Kitchen Food Safety Perceptions And Knowledge, Kailing Chen, Zhihong Lin, Isabelle Do Prado, Zahra Mohammad, Karla M. Acosta, Sujata A. Sirsat May 2024

College Students’ Domestic Kitchen Food Safety Perceptions And Knowledge, Kailing Chen, Zhihong Lin, Isabelle Do Prado, Zahra Mohammad, Karla M. Acosta, Sujata A. Sirsat

Journal of Extension

This study investigates college students’ current food safety knowledge and food-handling perceptions and utilized an online survey which designed based on previous studies as method. The questionnaire measured respondents’ food safety knowledge and perception, and were divided into knowledge, attitudes and perception categories. The results show that college students significantly lacked in basic food safety knowledge as well as food handling skills and implies a high need to develop enhanced food safety resources for college students, especially on topics related to cross-contamination prevention, correct food preparation procedures, time and temperature control, and awareness of pathogens that cause foodborne illness.


Hay Inventory And Purchasing Calculator For Horse Owners, Robyn L. Stewart, Brooklyne M. Wassel May 2024

Hay Inventory And Purchasing Calculator For Horse Owners, Robyn L. Stewart, Brooklyne M. Wassel

Journal of Extension

The Hay Inventory and Purchasing Calculator for Horse Owners is an Excel-based tool for estimating hay needs and expenses for horse owners. Challenges with hay quality and availability can result in higher than expected costs for horse owners as they attempt to purchase enough horse-quality hay to meet their needs. Estimating intake requirements and creating a budget for hay purchasing is key for the effective management and profitability of equine operations. This tool can be used regardless of geographic location and will benefit a diverse audience including Extension educators, equine business owners, and horse owners.


Assessment Of Gait, Balance, And Falls In Individuals With Neurodegenerative Diseases, Lauren Tueth May 2024

Assessment Of Gait, Balance, And Falls In Individuals With Neurodegenerative Diseases, Lauren Tueth

WUSM Theses and Dissertations – All Programs

Neurodegenerative diseases are a group of disorders that impact the brain and lead to neuronal degeneration. This degeneration causes many different symptoms, which are often grouped into motor, cognitive, and psychiatric domains. Individuals with these disorders can experience symptoms from multiple domains at the same time, but little is known about how these distinct symptoms may impact each other.

In Chapter 2, we explored the intersection of balance and cognitive impairment in individuals with Alzheimer disease (AD). AD is traditionally discussed in the context of the dementia symptoms, but people with AD also experience motor deficits. Falls are a huge …


Measurement Of And Contributors To Developmental Coordination Impairment, Jeffrey D. Konrad May 2024

Measurement Of And Contributors To Developmental Coordination Impairment, Jeffrey D. Konrad

WUSM Theses and Dissertations – All Programs

Movement drives childhood development. As motor skills improve across development, a child becomes capable of greater interactions with their physical and social environment. Children with motor impairments miss out on these interaction opportunities and their development across a variety of domains can suffer. There is accumulating evidence that poor motor competence relates to an array of developmental outcomes such as educational achievement, reading skills, social development, and emotional regulation. Two developmentally important motor impairments are poor motor competence and hyperactivity which are associated with Autism Spectrum Disorder (ASD), Developmental Coordination Disorder (DCD), and/or Attention Deficit Hyperactivity Disorder (ADHD). Critical to …


The Calcineurin-Nfatc Pathway Modulates The Lipid Mediators In Bal Fluid Extracellular Vesicles, Thereby Regulating Microvascular Endothelial Cell Barrier Function, Manjula Karpurapu, Yunjuan Nie, Sangwoon Chung, Jiasheng Yan, Patrick Dougherty, Sonal Pannu, Jon Wisler, Ryan Harkless, Narasimham Parinandi, Evgeny Berdyshev, Dehua Pei, John W Christman May 2024

The Calcineurin-Nfatc Pathway Modulates The Lipid Mediators In Bal Fluid Extracellular Vesicles, Thereby Regulating Microvascular Endothelial Cell Barrier Function, Manjula Karpurapu, Yunjuan Nie, Sangwoon Chung, Jiasheng Yan, Patrick Dougherty, Sonal Pannu, Jon Wisler, Ryan Harkless, Narasimham Parinandi, Evgeny Berdyshev, Dehua Pei, John W Christman

Faculty, Staff and Student Publications

Extracellular vesicles mediate intercellular communication by transporting biologically active macromolecules. Our prior studies have demonstrated that the nuclear factor of activated T cell cytoplasmic member 3 (NFATc3) is activated in mouse pulmonary macrophages in response to lipopolysaccharide (LPS). Inhibition of NFATc3 activation by a novel cell-permeable calcineurin peptide inhibitor CNI103 mitigated the development of acute lung injury (ALI) in LPS-treated mice. Although pro-inflammatory lipid mediators are known contributors to lung inflammation and injury, it remains unclear whether the calcineurin-NFATc pathway regulates extracellular vesicle (EV) lipid content and if this content contributes to ALI pathogenesis. In this study, EVs from mouse …


Targeting Ccl2/Ccr2 Signaling Overcomes Mek Inhibitor Resistance In Acute Myeloid Leukemia, Rucha V Modak, Katia G De Oliveira Rebola, John Mcclatchy, Mona Mohammadhosseini, Alisa Damnernsawad, Stephen E Kurtz, Christopher A Eide, Guanming Wu, Ted Laderas, Tamilla Nechiporuk, Marina A Gritsenko, Joshua R Hansen, Chelsea Hutchinson, Sara J C Gosline, Paul Piehowski, Daniel Bottomly, Nicholas Short, Karin Rodland, Shannon K Mcweeney, Jeffrey W Tyner, Anupriya Agarwal May 2024

Targeting Ccl2/Ccr2 Signaling Overcomes Mek Inhibitor Resistance In Acute Myeloid Leukemia, Rucha V Modak, Katia G De Oliveira Rebola, John Mcclatchy, Mona Mohammadhosseini, Alisa Damnernsawad, Stephen E Kurtz, Christopher A Eide, Guanming Wu, Ted Laderas, Tamilla Nechiporuk, Marina A Gritsenko, Joshua R Hansen, Chelsea Hutchinson, Sara J C Gosline, Paul Piehowski, Daniel Bottomly, Nicholas Short, Karin Rodland, Shannon K Mcweeney, Jeffrey W Tyner, Anupriya Agarwal

Faculty, Staff and Student Publications

Purpose: Emerging evidence underscores the critical role of extrinsic factors within the microenvironment in protecting leukemia cells from therapeutic interventions, driving disease progression, and promoting drug resistance in acute myeloid leukemia (AML). This finding emphasizes the need for the identification of targeted therapies that inhibit intrinsic and extrinsic signaling to overcome drug resistance in AML.

Experimental design: We performed a comprehensive analysis utilizing a cohort of ∼300 AML patient samples. This analysis encompassed the evaluation of secreted cytokines/growth factors, gene expression, and ex vivo drug sensitivity to small molecules. Our investigation pinpointed a notable association between elevated levels of CCL2 …


Transcriptomic Profiling Of Plasma Extracellular Vesicles Enables Reliable Annotation Of The Cancer-Specific Transcriptome And Molecular Subtype, Vahid Bahrambeigi, Jaewon J Lee, Vittorio Branchi, Kimal I Rajapakshe, Zhichao Xu, Naishu Kui, Jason T Henry, Wang Kun, Bret M Stephens, Sarah Dhebat, Mark W Hurd, Ryan Sun, Peng Yang, Eytan Ruppin, Wenyi Wang, Scott Kopetz, Anirban Maitra, Paola A Guerrero May 2024

Transcriptomic Profiling Of Plasma Extracellular Vesicles Enables Reliable Annotation Of The Cancer-Specific Transcriptome And Molecular Subtype, Vahid Bahrambeigi, Jaewon J Lee, Vittorio Branchi, Kimal I Rajapakshe, Zhichao Xu, Naishu Kui, Jason T Henry, Wang Kun, Bret M Stephens, Sarah Dhebat, Mark W Hurd, Ryan Sun, Peng Yang, Eytan Ruppin, Wenyi Wang, Scott Kopetz, Anirban Maitra, Paola A Guerrero

Faculty, Staff and Student Publications

Longitudinal monitoring of patients with advanced cancers is crucial to evaluate both disease burden and treatment response. Current liquid biopsy approaches mostly rely on the detection of DNA-based biomarkers. However, plasma RNA analysis can unleash tremendous opportunities for tumor state interrogation and molecular subtyping. Through the application of deep learning algorithms to the deconvolved transcriptomes of RNA within plasma extracellular vesicles (evRNA), we successfully predicted consensus molecular subtypes in patients with metastatic colorectal cancer. Analysis of plasma evRNA also enabled monitoring of changes in transcriptomic subtype under treatment selection pressure and identification of molecular pathways associated with recurrence. This approach …


Ataxia-Telangiectasia Mutated Loss-Of-Function Displays Variant And Tissue-Specific Differences Across Tumor Types, Patrick G Pilié, Virginia Giuliani, Wei-Lien Wang, Daniel J Mcgrail, Christopher A Bristow, Natalie Y L Ngoi, Keith Kyewalabye, Khalida M Wani, Hung Le, Erick Campbell, Nora S Sanchez, Dong Yang, Jinesh S Gheeya, Rohit Vivek Goswamy, Vijaykumar Holla, Kenna Rael Shaw, Funda Meric-Bernstam, Chiu-Yi Liu, Xiaoyan Ma, Ningping Feng, Annette A Machado, Jennifer P Bardenhagen, Christopher P Vellano, Joseph R Marszalek, Eeson Rajendra, Desiree Piscitello, Timothy I Johnson, Maria Likhatcheva, Elias Elinati, Jayesh Majithiya, Joana Neves, Vera Grinkevich, Marco Ranzani, Marina Roy Luzarraga, Marie Boursier, Lucy Armstrong, Lerin Geo, Giorgia Lillo, Wai Yiu Tse, Alexander J Lazar, Scott E Kopetz, Mary K Geck Do, Sarah Lively, Michael G Johnson, Helen M R Robinson, Graeme C M Smith, Christopher L Carroll, M Emilia Di Francesco, Philip Jones, Timothy P Heffernan, Timothy A Yap May 2024

Ataxia-Telangiectasia Mutated Loss-Of-Function Displays Variant And Tissue-Specific Differences Across Tumor Types, Patrick G Pilié, Virginia Giuliani, Wei-Lien Wang, Daniel J Mcgrail, Christopher A Bristow, Natalie Y L Ngoi, Keith Kyewalabye, Khalida M Wani, Hung Le, Erick Campbell, Nora S Sanchez, Dong Yang, Jinesh S Gheeya, Rohit Vivek Goswamy, Vijaykumar Holla, Kenna Rael Shaw, Funda Meric-Bernstam, Chiu-Yi Liu, Xiaoyan Ma, Ningping Feng, Annette A Machado, Jennifer P Bardenhagen, Christopher P Vellano, Joseph R Marszalek, Eeson Rajendra, Desiree Piscitello, Timothy I Johnson, Maria Likhatcheva, Elias Elinati, Jayesh Majithiya, Joana Neves, Vera Grinkevich, Marco Ranzani, Marina Roy Luzarraga, Marie Boursier, Lucy Armstrong, Lerin Geo, Giorgia Lillo, Wai Yiu Tse, Alexander J Lazar, Scott E Kopetz, Mary K Geck Do, Sarah Lively, Michael G Johnson, Helen M R Robinson, Graeme C M Smith, Christopher L Carroll, M Emilia Di Francesco, Philip Jones, Timothy P Heffernan, Timothy A Yap

Faculty, Staff and Student Publications

PURPOSE: Mutations in the ATM gene are common in multiple cancers, but clinical studies of therapies targeting ATM-aberrant cancers have yielded mixed results. Refinement of ATM loss of function (LOF) as a predictive biomarker of response is urgently needed.

EXPERIMENTAL DESIGN: We present the first disclosure and preclinical development of a novel, selective ATR inhibitor, ART0380, and test its antitumor activity in multiple preclinical cancer models. To refine ATM LOF as a predictive biomarker, we performed a comprehensive pan-cancer analysis of ATM variants in patient tumors and then assessed the ATM variant-to-protein relationship. Finally, we assessed a novel ATM LOF …


Integrative Molecular Analyses Of The Md Anderson Prostate Cancer Patient-Derived Xenograft (Mda Pca Pdx) Series, Nicolas Anselmino, Estefania Labanca, Peter D A Shepherd, Jiabin Dong, Jun Yang, Xiaofei Song, Subhiksha Nandakumar, Ritika Kundra, Cindy Lee, Nikolaus Schultz, Jianhua Zhang, John C Araujo, Ana M Aparicio, Sumit K Subudhi, Paul G Corn, Louis L Pisters, John F Ward, John W Davis, Elba S Vazquez, Geraldine Gueron, Christopher J Logothetis, Andrew Futreal, Patricia Troncoso, Yu Chen, Nora M Navone May 2024

Integrative Molecular Analyses Of The Md Anderson Prostate Cancer Patient-Derived Xenograft (Mda Pca Pdx) Series, Nicolas Anselmino, Estefania Labanca, Peter D A Shepherd, Jiabin Dong, Jun Yang, Xiaofei Song, Subhiksha Nandakumar, Ritika Kundra, Cindy Lee, Nikolaus Schultz, Jianhua Zhang, John C Araujo, Ana M Aparicio, Sumit K Subudhi, Paul G Corn, Louis L Pisters, John F Ward, John W Davis, Elba S Vazquez, Geraldine Gueron, Christopher J Logothetis, Andrew Futreal, Patricia Troncoso, Yu Chen, Nora M Navone

Faculty, Staff and Student Publications

PURPOSE: Develop and deploy a robust discovery platform that encompasses heterogeneity, clinical annotation, and molecular characterization and overcomes the limited availability of prostate cancer models. This initiative builds on the rich MD Anderson (MDA) prostate cancer (PCa) patient-derived xenograft (PDX) resource to complement existing publicly available databases by addressing gaps in clinically annotated models reflecting the heterogeneity of potentially lethal and lethal prostate cancer.

EXPERIMENTAL DESIGN: We performed whole-genome, targeted, and RNA sequencing in representative samples of the same tumor from 44 PDXs derived from 38 patients linked to donor tumor metadata and corresponding organoids. The cohort includes models derived …


Ire1Α Determines Ferroptosis Sensitivity Through Regulation Of Glutathione Synthesis, Dadi Jiang, Youming Guo, Tianyu Wang, Liang Wang, Yuelong Yan, Ling Xia, Rakesh Bam, Zhifen Yang, Hyemin Lee, Takao Iwawaki, Boyi Gan, Albert C Koong May 2024

Ire1Α Determines Ferroptosis Sensitivity Through Regulation Of Glutathione Synthesis, Dadi Jiang, Youming Guo, Tianyu Wang, Liang Wang, Yuelong Yan, Ling Xia, Rakesh Bam, Zhifen Yang, Hyemin Lee, Takao Iwawaki, Boyi Gan, Albert C Koong

Faculty, Staff and Student Publications

Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein response (UPR), also determines cellular sensitivity to ferroptosis. Cancer and normal cells depleted of IRE1α gain resistance to ferroptosis, while enhanced IRE1α expression promotes sensitivity to ferroptosis. Mechanistically, IRE1α's endoribonuclease activity cleaves and down-regulates the mRNA of key glutathione biosynthesis regulators glutamate-cysteine ligase catalytic subunit (GCLC) and solute carrier family 7 member 11 (SLC7A11). This activity of IRE1α is independent of its role in regulating the UPR and is …


Carbon Stocks And Fluxes From A Boreal Conifer Swamp: Filling A Knowledge Gap For Understanding The Boreal C Cycle, Sj Davidson, Marissa Davies, E Wegener, S Claussen, M Schmidt, M Peacock, M Strack May 2024

Carbon Stocks And Fluxes From A Boreal Conifer Swamp: Filling A Knowledge Gap For Understanding The Boreal C Cycle, Sj Davidson, Marissa Davies, E Wegener, S Claussen, M Schmidt, M Peacock, M Strack

School of Geography, Earth and Environmental Sciences

The carbon (C) dynamics of boreal coniferous swamps are a largely understudied component of wetland carbon cycling. We investigated the above- and below-ground carbon stocks and growing season carbon dioxide (CO 2) and methane (CH 4) fluxes from a representative boreal coniferous swamp in northern Alberta, Canada in 2022. Tree inventories, understory vegetation biomass and peat cores were collected across three sub-sites within the broader swamp, with gas flux collars placed in the dominant plant communities present. Alongside the C flux measurements, environmental variables such as water table depth, soil temperature and growing season understory green leaf phenology …


Explosions Of Cold War Memory: The Queer Overdetermination Of U.S. Imperial Anxiety In The Ugly American, Jasmine Shirey May 2024

Explosions Of Cold War Memory: The Queer Overdetermination Of U.S. Imperial Anxiety In The Ugly American, Jasmine Shirey

Dartmouth College Master’s Theses

In 1958, William Lederer and Eugene Burdick were driven to spend six days frantically drafting a novel. In their view, the United States was losing the Cold War and the nation’s post-war image of innovation and benevolence was under threat. Lederer and Burdick feared that U.S. diplomacy was chauvinistic and detached and, as such, the United States was beginning to be associated with the very forms of imperialism it claimed to fight. This anxiety over U.S. imperialism gave rise to The Ugly American, in which Lederer and Burdick appear to attempt to alleviate imperial anxieties by providing an alternative …


Towards Machine Proficiency With Semantic Underspecification, Zachary S. Gottesman May 2024

Towards Machine Proficiency With Semantic Underspecification, Zachary S. Gottesman

Dartmouth College Master’s Theses

Human natural language communication frequently relies on extra-linguistic information to fill in gaps in the linguistic signal left by semantic underspecification, or the omission of details that can be inferred from prior knowledge or other modalities. Underspecification is particularly common in conversations between acquaintances, since these interlocutors share context. Underspecification is a key and beneficial feature of natural language that improves efficiency, although it can cause communication to fail if it is not resolved correctly. For language models to communicate effectively and in a human-like fashion, they must learn how to recognize and utilize underspecified language. This thesis argues that …


Designing Future Agriculture: Design For Complex Systems And Cross-Cultural Interactions, Karina Madzari May 2024

Designing Future Agriculture: Design For Complex Systems And Cross-Cultural Interactions, Karina Madzari

Dartmouth College Master’s Theses

Climate change is now recognized by businesses as a major challenge, prompting the agribusiness sector to transform to meet sustainability goals. However, there are many ways to achieve sustainability. Precision agriculture and agroecology are two concepts that evolved from conventional and regenerative approaches respectively, and offer distinct perspectives on sustainability attainment. Precision agriculture relies on technological solutions like artificial intelligence (AI), robotics, gene editing, and carbon dioxide removal technologies (CDR) and aims to revolutionize industry operations through automatization. Agroecology, on the other hand, creates a symbiotic relationship between farming practices and ecosystem services. It aims to replace non-renewable resources with …


Testing Hadronic-Model Predictions Of Depth Of Maximum Of Air-Shower Profiles And Ground-Particle Signals Using Hybrid Data Of The Pierre Auger Observatory, A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, B. Fick, K. Nguyen, D. Nitz, Et Al. May 2024

Testing Hadronic-Model Predictions Of Depth Of Maximum Of Air-Shower Profiles And Ground-Particle Signals Using Hybrid Data Of The Pierre Auger Observatory, A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, B. Fick, K. Nguyen, D. Nitz, Et Al.

Michigan Tech Publications

We test the predictions of hadronic interaction models regarding the depth of maximum of air-shower profiles, Xmax, and ground-particle signals in water-Cherenkov detectors at 1000 m from the shower core, S(1000), using the data from the fluorescence and surface detectors of the Pierre Auger Observatory. The test consists of fitting the measured two-dimensional (S(1000), Xmax) distributions using templates for simulated air showers produced with hadronic interaction models epos-lhc, qgsjet-ii-04, sibyll 2.3d and leaving the scales of predicted Xmax and the signals from hadronic component at ground as free-fit parameters. The method relies on the assumption that the mass composition remains …


Nidus Idearum. Scilogs, Xiii: Structure / Neutrostructure / Antistructure, Florentin Smarandache May 2024

Nidus Idearum. Scilogs, Xiii: Structure / Neutrostructure / Antistructure, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In this thirteenth book of scilogs – one may find topics on Neutrosophy, Plithogeny, Physics, Mathematics, Philosophy – email messages to research colleagues, or replies, notes, comments, remarks about authors, articles, or books, spontaneous ideas, and so on. It presents new types of soft sets and new types of topologies.

Exchanging ideas with Mohammad Abobala, Ishfaq Ahmad, Ibrahim M. Almanjahie, Fatimah Alshahrani, Nizar Altounji, Muhammad Aslam, Said Broumi, Victor Christianto, R. Diksh, Feng Liu, Frank Julian Gelli, Erick Gonzalez Caballero, Riad Hamido, Yaser Al-Hasan, Ahmed Hatip, Yasin Karmouta, Nivetha Martin, Preda Mihăilescu, V. Lakshmana Gomathi Nayagam, Ze Carlos Tiago de …


Development And Evaluation Of Muon Scattering Tomography Reconstruction Techniques For Spent Fuel Verification, Jesus J. Valencia May 2024

Development And Evaluation Of Muon Scattering Tomography Reconstruction Techniques For Spent Fuel Verification, Jesus J. Valencia

Nuclear Engineering ETDs

The International Atomic Energy Agency has acknowledged the need to “efficiently verify and maintain knowledge of spent fuel in shielding/storage/transport containers at all points in their life cycle”. Cosmic-ray muon scattering tomography has shown potential to create reconstruction images of dry cask contents that would be useful for in-situ verification of spent fuel within dry casks.

In this document, several muon scattering tomography reconstruction techniques are explored using experimental track data through a partially filled dry cask container and steel drum test object. Two three-dimensional reconstruction techniques, a backprojection and newly developed combined depth of field algorithm, are evaluated. The …


An Innovative Approach On Yao’S Three-Way Decision Model Using Intuitionistic Fuzzy Sets For Medical Diagnosis, Wajid Ali, Tanzeela Shaheen, Iftikhar Ul Haq, Florentin Smarandache, Hamza Ghazanfar Toor, Faiza Asif May 2024

An Innovative Approach On Yao’S Three-Way Decision Model Using Intuitionistic Fuzzy Sets For Medical Diagnosis, Wajid Ali, Tanzeela Shaheen, Iftikhar Ul Haq, Florentin Smarandache, Hamza Ghazanfar Toor, Faiza Asif

Neutrosophic Systems with Applications

In the realm of medical diagnosis, intuitionistic fuzzy data serves as a valuable tool for representing information that is uncertain and imprecise. Nevertheless, decision-making based on this kind of knowledge can be quite challenging due to the inherent vagueness of the data. To address this issue, we employ power aggregation operators, which prove effective in combining several sources of data, such as expert thoughts and patient information. This allows for a more correct diagnosis; a particularly crucial aspect of medical practice where precise and timely diagnoses can significantly impact medication policy and patient results. In our research, we introduce a …


The Crucible Of War: The Personal History Of A Social Democrat In Nazi Germany, Michael Tetto May 2024

The Crucible Of War: The Personal History Of A Social Democrat In Nazi Germany, Michael Tetto

The Thetean: A Student Journal for Scholarly Historical Writing

On Christmas Day 1943, Somewhere in Russia, Siegfried Sinz enjoyed a jovial moment with his unit of the German Army. It was a refreshing break from the trials of war, for he had been on the eastern front since June of 1941. Cautiousness, endemic of their proximity to the battle front, attended the preparations for the event. All windows needed to be sealed to prevent light from escaping into the night lest any Russians on patrol ascertain their location and attack. Unfortunately, someone did not seal one of the windows completely; a ray of light escaped to illuminate the darkened …