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Race Against The Clock: A Comparative Analysis Of New York State's And Germany's Ambitious High-Voltage Transmission Sitting Laws And What New York Can Adopt From The German Model, Andrew Leahy Jul 2024

Race Against The Clock: A Comparative Analysis Of New York State's And Germany's Ambitious High-Voltage Transmission Sitting Laws And What New York Can Adopt From The German Model, Andrew Leahy

Cardozo International & Comparative Law Review

The note argues that New York should adopt elements of Germany's centralized regulatory model to streamline the approval and construction of high-voltage transmission lines, which are critical for meeting renewable energy goals. While both New York and Germany face similar challenges in expanding their grids, Germany's centralized approach, including federal oversight and coordinated planning, has proven more efficient. The note critiques New York's decentralized and uncoordinated process, suggesting that adopting Germany's methods could help New York meet its ambitious renewable energy targets and reduce reliance on peaker plants.


2. Faculty, Saint Mary's College Of California Jul 2024

2. Faculty, Saint Mary's College Of California

Faculty Handbook

No abstract provided.


Exchange Rates And Fundamentals In Developed And Emerging Markets, Rocky K. Laurel Jul 2024

Exchange Rates And Fundamentals In Developed And Emerging Markets, Rocky K. Laurel

DLSU Business & Economics Review

This paper investigates the relationship between exchange rates on the one hand and money supply and real output on the other, then compares the relationship in developed and emerging markets. It tests the validity of the flexible price monetary model using in-sample analysis to determine if there are long-term relationships among the variables and out-of-sample analysis to compare the predictive performance of the model against a random walk. It finds evidence for a relationship as predicted by the model, contrary to long-standing findings of no relationship. It also finds some evidence that foreign exchange rates of emerging markets are more …


The Yields That Bind: Treasury Bill Yields And The Philippine Corporate Bond Yield Spreads (Pre-Covid 2012–2019), Maurice Arce, Carlos Dorado, Justine Pascua, Paul Robles, Junette Perez Jul 2024

The Yields That Bind: Treasury Bill Yields And The Philippine Corporate Bond Yield Spreads (Pre-Covid 2012–2019), Maurice Arce, Carlos Dorado, Justine Pascua, Paul Robles, Junette Perez

DLSU Business & Economics Review

The paper’s base reference is Duffee (1998). He examined the inverse relationship between the U.S. Treasury bill yields (TBY) and the corporate bond yield spreads (CBYS). Eight years of historical data on the Philippine CBYS from 2012–2019 and data on TBY were analyzed using OLS regression. To examine, if the results hold in the Philippines and given that the bond market in the country differs from the U.S. bond markets, will the results of Duffee (1998) persist? Although the paper focused on providing evidence on one of the most basic, well-established inverse relationships between TBY and inflation to CBYS, the …


2023 Kahramanmaras Earthquake Sequence: Geospatial Visualization And Analysis Of Multiple Building Damage Datasets, Alejandra Bravo, Jerry Hue Truong Luong, Anahid Behrouzi Jul 2024

2023 Kahramanmaras Earthquake Sequence: Geospatial Visualization And Analysis Of Multiple Building Damage Datasets, Alejandra Bravo, Jerry Hue Truong Luong, Anahid Behrouzi

Architectural Engineering

To learn from past earthquake events, a critical task is validating observations with data. After a significant seismic event like the 2023 Kahramanmaras Türkiye earthquake series, various organizations perform reconnaissance efforts to collect building response data. Some reconnaissance missions focus on visiting fewer buildings and recording detailed information (high-resolution, HR), while others aim to visit as many buildings as possible recording basic information (low-resolution, LR). Both dataset types are vital for learning, and the next step is analyzing and visualizing the data to validate in-field observations. This paper has three purposes: 1) examine a HR dataset by Degenkolb with 138 …


The Role Of Executive Function In Cognitive Reappraisal: A Meta-Analytic Review, Wei Xing Toh, Jun Sheng Keh, James J. Gross, Laura L. Carstensen Jul 2024

The Role Of Executive Function In Cognitive Reappraisal: A Meta-Analytic Review, Wei Xing Toh, Jun Sheng Keh, James J. Gross, Laura L. Carstensen

Research Collection School of Social Sciences

Cognitive reappraisal refers to the reinterpretation of a situation to alter its emotional meaning. Theoretically, executive functions (EFs), such as inhibition, updating, and shifting, are core elements of reappraisal processes. However, empirical studies have yielded inconsistent evidence as to whether and to what extent EFs are associated with reappraisal. To address this issue, we conducted a meta-analysis of the literature in which 179 effect sizes from 59 independent samples (N = 4,703) were included. Using random-effects metaregression with robust-variance estimates and small-sample corrections, we also examined whether variation in effect sizes could be accounted for by potential moderators, such as …


Time-Restricted Feeding Reveals A Role For Neural Respiratory Clocks In Optimizing Daily Ventilatory-Metabolic Coupling In Mice, Aaron A. Jones, Gabriella M. Marino, Deanna M. Arble Jul 2024

Time-Restricted Feeding Reveals A Role For Neural Respiratory Clocks In Optimizing Daily Ventilatory-Metabolic Coupling In Mice, Aaron A. Jones, Gabriella M. Marino, Deanna M. Arble

Biological Sciences Faculty Research and Publications

The master circadian clock, located in the suprachiasmatic nuclei (SCN), organizes the daily rhythm in minute ventilation (V̇e). However, the extent that the daily rhythm in V̇e is secondary to SCN-imposed O2 and CO2 cycles (i.e., metabolic rate) or driven by other clock mechanisms remains unknown. Here, we experimentally shifted metabolic rate using time-restricted feeding (without affecting light-induced synchronization of the SCN) to determine the influence of metabolic rate in orchestrating the daily V̇e rhythm. Mice eating predominantly at night exhibited robust daily rhythms in O2 consumption (V̇o2), CO2 production (V̇co2), and V̇e with similar peak times (approximately ZT18) that …


Perceptions Of Communities Of Practice And Sense Of Belonging: Focus Groups Of Academic Pediatric Faculty, Margaret P. Huntwork, Myo T. Myint, Emma Simon, Bonnie Desselle, Amy M. Creel Jul 2024

Perceptions Of Communities Of Practice And Sense Of Belonging: Focus Groups Of Academic Pediatric Faculty, Margaret P. Huntwork, Myo T. Myint, Emma Simon, Bonnie Desselle, Amy M. Creel

School of Medicine Faculty Publications

BACKGROUND: Providing the opportunity for collaboration around a central purpose to improve skills and exchange knowledge, the Community of Practice model can be useful for faculty development. A sense of belonging enhances the engagement in communities. Yet, the barriers and contributors to academic medicine faculty's sense of belonging in communities are not as well explored. METHODS: Through focus groups with 21 academic pediatric faculty conducted between January and March 2023, this qualitative study examined knowledge of Communities of Practice and the factors that affect sense of belonging and engagement. The authors iteratively coded transcripts to generate themes. RESULTS: Community accessibility; …


Assessing Rice Phenological Features With Hyperspectral Imaging Insights From Earth Surface Mineral Dust Source Investigation (Emit), Shahryar Fazli, Wenzhao Li, Surendra Maharjan, Hesham El-Askary Jul 2024

Assessing Rice Phenological Features With Hyperspectral Imaging Insights From Earth Surface Mineral Dust Source Investigation (Emit), Shahryar Fazli, Wenzhao Li, Surendra Maharjan, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

In California's Central Valley, water management and crop health, particularly in rice cultivation, are critical. This paper details the application of Earth surface Mineral dust source InvesTigation (EMIT) hyperspectral imaging, specifically employing Spectral Correlation Mapper (SCM) and Spectral Information Divergence (SID), for precise phenological analysis. By aligning EMIT data with Hyperion satellite references, we address spectral and geographical discrepancies. Our methodology includes seasonal sampling of spectral curves to capture the phenological stages of rice. Results show a strong correlation (R 2 = 0.86) between August EMIT and Reference dataset, emphasizing EMIT's utility in enhancing agricultural practices and water efficiency in …


Derivative Propagation Through Vortex Particle Method Simulation, Eric Green, Andrew Ning Jul 2024

Derivative Propagation Through Vortex Particle Method Simulation, Eric Green, Andrew Ning

Faculty Publications

Automatic differentiation (AD) is a powerful tool for evaluating numerical derivatives. In particular, reverse-mode AD provides numerical gradients in a way that is insensitive to the number of input variables. This makes reverse-mode AD well-suited for solving large optimization problems. However, reverse-mode AD has a particularly large associated memory cost because most intermediate values in operations need to be cached. This is problematic for large problems such as aerodynamics simulations, though, since the memory requirements can quickly become impractical. The solution implemented in this work is to provide analytic pullback expressions for functions for which many of the intermediate values …


Trajectory Optimization Of Evtol And Conventional Aircraft: A Comparative Analysis Of Vortex Particle Method And Vortex Lattice + Blade Element Momentum Theory, Andrew Tagg, Ryan Anderson, Cibin Joseph, Andrew Ning Jul 2024

Trajectory Optimization Of Evtol And Conventional Aircraft: A Comparative Analysis Of Vortex Particle Method And Vortex Lattice + Blade Element Momentum Theory, Andrew Tagg, Ryan Anderson, Cibin Joseph, Andrew Ning

Faculty Publications

Trajectory optimization of aircraft transition maneuvers can significantly influence the design of these systems, particularly when making decisions about aircraft geometry, propulsion sizing, and control system design. This paper presents the trajectory optimization of air vehicles including electric vertical takeoff and landing (eVTOL) as well as conventional aircraft. The study evaluates the influence of fidelity in trajectory design by comparing the use of two aerodynamic methods in the context of trajectory optimization. The mid-fidelity method utilizes a vortex lattice method (VLM) to model lifting surfaces while employing blade element momentum theory (BEMT) to model rudimentary rotor-wing interactions. The high-fidelity approach …


Attribute-Based Fine-Grained Access Control Using Verifiable Credentials, Srinivasa Dumpa Jul 2024

Attribute-Based Fine-Grained Access Control Using Verifiable Credentials, Srinivasa Dumpa

Student Theses

In the era of digital transformation, ensuring secure and privacy-preserving access control mechanisms is of paramount importance. Traditional identity-based access control systems often fall short in providing granular control and user autonomy over digital identities. This thesis presents a novel approach to access control by leveraging the power of verifiable credentials and attribute-based access control. The proposed system introduces a decentralized and user-centric framework that enables fine-grained access control based on specific attributes encapsulated within verifiable credentials. These tamper-evident digital credentials, stored in a user's digital wallet, contain a rich set of attributes that can be selectively disclosed to grant …


Implementation, Evolution, And Laboratory Performance Of Methods-Based Proficiency Testing For Next-Generation Sequencing Detection Of Germline Sequence Variants, Karen D Tsuchiya, Birgit Funke, Madhuri Hegde, Avni Santani, Rhona J Souers, Szabolcs Szelinger, Jaimie Halley, Qin Zhao, Nicole Mot, Angshumoy Roy, Vanessa L Smith, Bing M Zhang, Karl Voelkerding, Ann M Moyer Jul 2024

Implementation, Evolution, And Laboratory Performance Of Methods-Based Proficiency Testing For Next-Generation Sequencing Detection Of Germline Sequence Variants, Karen D Tsuchiya, Birgit Funke, Madhuri Hegde, Avni Santani, Rhona J Souers, Szabolcs Szelinger, Jaimie Halley, Qin Zhao, Nicole Mot, Angshumoy Roy, Vanessa L Smith, Bing M Zhang, Karl Voelkerding, Ann M Moyer

Faculty, Staff and Students Publications

Context.—: Next-generation sequencing (NGS)-based assays are used for diagnosis of diverse inherited disorders. Limited data are available pertaining to interlaboratory analytical performance of these assays.

Objective.—: To report on the College of American Pathologists (CAP) NGS Germline Program, which is methods based, and explore the evolution in laboratory testing practices.

Design.—: Results from the NGS Germline Program from 2016-2020 were analyzed for interlaboratory analytical performance. Self-reported laboratory testing practices were also evaluated.

Results.—: From 2016-2020, a total of 297 laboratories participated in at least 1 program mailing. Of the 289 laboratories that provided information on tests offered, 138 (47.8%) offered …


Dna-Delivered Monoclonal Antibodies Targeting The P53 R175h Mutant Epitope Inhibit Tumor Development In Mice, Dafei Chai, Xu Wang, Praveen Neeli, Shan Zhou, Xingfang Yu, Kanaga Sabapathy, Yong Li Jul 2024

Dna-Delivered Monoclonal Antibodies Targeting The P53 R175h Mutant Epitope Inhibit Tumor Development In Mice, Dafei Chai, Xu Wang, Praveen Neeli, Shan Zhou, Xingfang Yu, Kanaga Sabapathy, Yong Li

Faculty, Staff and Students Publications

The tumor suppressor p53 is the most common mutated gene in cancer, with the R175H as the most frequent p53 missense mutant. However, there are currently no approved targeted therapies or immunotherapies against mutant p53. Here, we characterized and investigated a monoclonal antibody (mAb) that recognizes the mutant p53-R175H for its affinity, specificity, and activity against tumor cells in vitro. We then delivered DNA plasmids expressing the anti-R175H mAb or a bispecific antibody (BsAb) into mice to evaluate their therapeutic effects. Our results showed that the anti-R175H mAb specifically bound to the p53-R175H antigen with a high affinity and …


Value Of 2d Shear Wave Elastography In Suspicious Thyroid Nodules, Huda Hameed, Raad Abidtwfeq Jul 2024

Value Of 2d Shear Wave Elastography In Suspicious Thyroid Nodules, Huda Hameed, Raad Abidtwfeq

Iraqi Postgraduate Medical Journal

Background: Thyroid nodules are found in one every two people, who checked under ultrasonography examination. Though only 4-7% are clinically noticeable, there is increased in cancer incidence. Shear wave elastography (SWE) is simple noninvasive method to differentiate between benign and malignant nodules.Aim of the study: to assess the differences in shear wave elastography indices between benign and malignant thyroid nodules by generating a cutoff value with best sensitivity and specificity.Patient and Methods: a total of 55 patients with solid thyroid nodules were evaluated by conventional ultrasonography and shear wave elastography were mean shear wave elasticity indices measured followed by ultrasound …


Application Of Clavien-Dindo Classification System In The Early Complications Of Radical Cystectomy In Al-Yarmook Teaching Hospital, Ahmed Abbass Al-Sadie, Saad Al-Sammarraie, Taha Kadhum Jul 2024

Application Of Clavien-Dindo Classification System In The Early Complications Of Radical Cystectomy In Al-Yarmook Teaching Hospital, Ahmed Abbass Al-Sadie, Saad Al-Sammarraie, Taha Kadhum

Iraqi Postgraduate Medical Journal

BACKGROUND: The most effective treatment for muscle-invasive bladder cancer and non-muscle invasive bladder cancer with highest risk of progression, is Radical cystectomy and urinary diversion. This operation carries                  a high risk of complications of multiple types that can affect not only the urinary system but also other systems. OBJECTIVE: This study analyzes the early complications (within 30 days) of Radical Cystectomy and urinary diversion, using a standardized classification system i.e. Clavien-Dindo classification system. PATIENTS AND METHODS: This is a combined retrospective and prospective study analyzing the early complications of RC.                    We review the early (30 days) post-operative period retrospectively for …


Diagnostic Efficacy Of Digital Breast Tomosynthesis With Digital Mammography In Bi-Rads Iv And V Breast Lesions, Raad Abedtwfeq, Raghda Mekhael Jul 2024

Diagnostic Efficacy Of Digital Breast Tomosynthesis With Digital Mammography In Bi-Rads Iv And V Breast Lesions, Raad Abedtwfeq, Raghda Mekhael

Iraqi Postgraduate Medical Journal

BACKGROUND: Breast cancer is comments type of cancer in women, and the second leading cause of death worldwide. Mammography had been the cornerstone for breast cancer diagnosis throughout the years.                     Digital breast tomosynthesis had been developed as an advanced method for early diagnosing a breast lesion and found to have promising results in both screening and diagnostic measures more importantly in dense and previously treated breasts. OBJECTIVE: To evaluate digital breast tomosynthesis (DBT) compared to digital mammography for the detection of different breast lesions and interpretations of BIRADS IV and V scoring in different breast densities. PATIENTS AND METHODS: A …


Reducing Student Anxiety Using Neurofeedback-Assisted Mindfulness: A Quasi-Experimental Single-Case Design, David Christian, Cian L. Brown, Evan C. Smarinsky, Erin K. Popejoy, Allison Ames Boykin Jul 2024

Reducing Student Anxiety Using Neurofeedback-Assisted Mindfulness: A Quasi-Experimental Single-Case Design, David Christian, Cian L. Brown, Evan C. Smarinsky, Erin K. Popejoy, Allison Ames Boykin

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

The authors implemented an A–B–A with follow-up quasi-experimental single-case research design to assess the effectiveness of a consumer-grade neurofeedback (NFB)-assisted mindfulness-based intervention (MBI) for reducing anxiety in high-achieving high school students (N = 5). Three of the participants from racial/ethnic minority and lower socioeconomic status (SES) backgrounds reported reduced anxiety as measured by the State-Trait Anxiety Inventory for Youth (STAI-Y) during the intervention. In contrast, the two participants who identified as White, higher SES did not report decreased anxiety during the intervention. Results provide initial support for the use of the NFB-assisted MBI used in this study as a …


A Klf2-Bmper-Smad1/5 Checkpoint Regulates High Fluid Shear Stress-Mediated Artery Remodeling, Hanqiang Deng, Jiasheng Zhang, Yewei Wang, Divyesh Joshi, Xinchun Pi, Sarah De Val, Martin A Schwartz Jul 2024

A Klf2-Bmper-Smad1/5 Checkpoint Regulates High Fluid Shear Stress-Mediated Artery Remodeling, Hanqiang Deng, Jiasheng Zhang, Yewei Wang, Divyesh Joshi, Xinchun Pi, Sarah De Val, Martin A Schwartz

Faculty, Staff and Students Publications

Vascular remodeling to match arterial diameter to tissue requirements commonly fails in ischemic disease. Endothelial cells sense fluid shear stress (FSS) from blood flow to maintain FSS within a narrow range in healthy vessels. Thus, high FSS induces vessel outward remodeling, but mechanisms are poorly understood. We previously reported that Smad1/5 is maximally activated at physiological FSS. Smad1/5 limits Akt activation, suggesting that inhibiting Smad1/5 may facilitate outward remodeling. Here we report that high FSS suppresses Smad1/5 by elevating KLF2, which induces the bone morphogenetic protein (BMP) pathway inhibitor, BMP-binding endothelial regulator (BMPER), thereby de-inhibiting Akt. In mice, surgically induced …


Understanding The Genetic Complexity Of Puberty Timing Across The Allele Frequency Spectrum, Katherine A Kentistou, Lena R Kaisinger, Stasa Stankovic, Marc Vaudel, Edson Mendes De Oliveira, Andrea Messina, Robin G Walters, Xiaoxi Liu, Alexander S Busch, Hannes Helgason, Deborah J Thompson, Federico Santoni, Konstantin M Petricek, Yassine Zouaghi, Isabel Huang-Doran, Daniel F Gudbjartsson, Eirik Bratland, Kuang Lin, Eugene J Gardner, Yajie Zhao, Raina Y Jia, Chikashi Terao, Marjorie J Riggan, Manjeet K Bolla, Mojgan Yazdanpanah, Nahid Yazdanpanah, Jonathan P Bradfield, Linda Broer, Archie Campbell, Daniel I Chasman, Diana L Cousminer, Nora Franceschini, Lude H Franke, Giorgia Girotto, Chunyan He, Marjo-Riitta Järvelin, Peter K Joshi, Yoichiro Kamatani, Robert Karlsson, Jian'an Luan, Kathryn L Lunetta, Reedik Mägi, Massimo Mangino, Sarah E Medland, Christa Meisinger, Raymond Noordam, Teresa Nutile, Maria Pina Concas, Ozren Polašek, Eleonora Porcu, Susan M Ring, Cinzia Sala, Albert V Smith, Toshiko Tanaka, Peter J Van Der Most, Veronique Vitart, Carol A Wang, Gonneke Willemsen, Marek Zygmunt, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Paul L Auer, Catriona L K Barnes, Matthias W Beckmann, Amy Berrington De Gonzalez, Natalia V Bogdanova, Stig E Bojesen, Hermann Brenner, Julie E Buring, Federico Canzian, Jenny Chang-Claude, Fergus J Couch, Angela Cox, Laura Crisponi, Kamila Czene, Mary B Daly, Ellen W Demerath, Joe Dennis, Peter Devilee, Immaculata De Vivo, Thilo Dörk, Alison M Dunning, Miriam Dwek, Johan G Eriksson, Peter A Fasching, Lindsay Fernandez-Rhodes, Liana Ferreli, Olivia Fletcher, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Anna González-Neira, Harald Grallert, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Hakon Hakonarson, Roger J Hart, Martha Hickey, Maartje J Hooning, Reiner Hoppe, John L Hopper, Jouke-Jan Hottenga, Frank B Hu, Hanna Huebner, David J Hunter, Helena Jernström, Esther M John, David Karasik, Elza K Khusnutdinova, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Lenore J Launer, Penelope A Lind, Annika Lindblom, Patrik K E Magnusson, Arto Mannermaa, Mark I Mccarthy, Thomas Meitinger, Cristina Menni, Kyriaki Michailidou, Iona Y Millwood, Roger L Milne, Grant W Montgomery, Heli Nevanlinna, Ilja M Nolte, Dale R Nyholt, Nadia Obi, Katie M O'Brien, Kenneth Offit, Albertine J Oldehinkel, Sisse R Ostrowski, Aarno Palotie, Ole B Pedersen, Annette Peters, Giulia Pianigiani, Dijana Plaseska-Karanfilska, Anneli Pouta, Alfred Pozarickij, Paolo Radice, Gad Rennert, Frits R Rosendaal, Daniela Ruggiero, Emmanouil Saloustros, Dale P Sandler, Sabine Schipf, Carsten O Schmidt, Marjanka K Schmidt, Kerrin Small, Beatrice Spedicati, Meir Stampfer, Jennifer Stone, Rulla M Tamimi, Lauren R Teras, Emmi Tikkanen, Constance Turman, Celine M Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Babette S Zemel, Wei Zheng, Ko W Van Dijk, Behrooz Z Alizadeh, Stefania Bandinelli, Eric Boerwinkle, Dorret I Boomsma, Marina Ciullo, Georgia Chenevix-Trench, Francesco Cucca, Tõnu Esko, Christian Gieger, Struan F A Grant, Vilmundur Gudnason, Caroline Hayward, Ivana Kolčić, Peter Kraft, Deborah A Lawlor, Nicholas G Martin, Ellen A Nøhr, Nancy L Pedersen, Craig E Pennell, Paul M Ridker, Antonietta Robino, Harold Snieder, Ulla Sovio, Tim D Spector, Doris Stöckl, Cathie Sudlow, Nic J Timpson, Daniela Toniolo, André Uitterlinden, Sheila Ulivi, Henry Völzke, Nicholas J Wareham, Elisabeth Widen, James F Wilson, Lifelines Cohort Study, Danish Blood Donor Study, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Biobank Japan Project, China Kadoorie Biobank Collaborative Group, Paul D P Pharoah, Liming Li, Douglas F Easton, Pål R Njølstad, Patrick Sulem, Joanne M Murabito, Anna Murray, Despoina Manousaki, Anders Juul, Christian Erikstrup, Kari Stefansson, Momoko Horikoshi, Zhengming Chen, I Sadaf Farooqi, Nelly Pitteloud, Stefan Johansson, Felix R Day, John R B Perry, Ken K Ong Jul 2024

Understanding The Genetic Complexity Of Puberty Timing Across The Allele Frequency Spectrum, Katherine A Kentistou, Lena R Kaisinger, Stasa Stankovic, Marc Vaudel, Edson Mendes De Oliveira, Andrea Messina, Robin G Walters, Xiaoxi Liu, Alexander S Busch, Hannes Helgason, Deborah J Thompson, Federico Santoni, Konstantin M Petricek, Yassine Zouaghi, Isabel Huang-Doran, Daniel F Gudbjartsson, Eirik Bratland, Kuang Lin, Eugene J Gardner, Yajie Zhao, Raina Y Jia, Chikashi Terao, Marjorie J Riggan, Manjeet K Bolla, Mojgan Yazdanpanah, Nahid Yazdanpanah, Jonathan P Bradfield, Linda Broer, Archie Campbell, Daniel I Chasman, Diana L Cousminer, Nora Franceschini, Lude H Franke, Giorgia Girotto, Chunyan He, Marjo-Riitta Järvelin, Peter K Joshi, Yoichiro Kamatani, Robert Karlsson, Jian'an Luan, Kathryn L Lunetta, Reedik Mägi, Massimo Mangino, Sarah E Medland, Christa Meisinger, Raymond Noordam, Teresa Nutile, Maria Pina Concas, Ozren Polašek, Eleonora Porcu, Susan M Ring, Cinzia Sala, Albert V Smith, Toshiko Tanaka, Peter J Van Der Most, Veronique Vitart, Carol A Wang, Gonneke Willemsen, Marek Zygmunt, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Paul L Auer, Catriona L K Barnes, Matthias W Beckmann, Amy Berrington De Gonzalez, Natalia V Bogdanova, Stig E Bojesen, Hermann Brenner, Julie E Buring, Federico Canzian, Jenny Chang-Claude, Fergus J Couch, Angela Cox, Laura Crisponi, Kamila Czene, Mary B Daly, Ellen W Demerath, Joe Dennis, Peter Devilee, Immaculata De Vivo, Thilo Dörk, Alison M Dunning, Miriam Dwek, Johan G Eriksson, Peter A Fasching, Lindsay Fernandez-Rhodes, Liana Ferreli, Olivia Fletcher, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Anna González-Neira, Harald Grallert, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Hakon Hakonarson, Roger J Hart, Martha Hickey, Maartje J Hooning, Reiner Hoppe, John L Hopper, Jouke-Jan Hottenga, Frank B Hu, Hanna Huebner, David J Hunter, Helena Jernström, Esther M John, David Karasik, Elza K Khusnutdinova, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Lenore J Launer, Penelope A Lind, Annika Lindblom, Patrik K E Magnusson, Arto Mannermaa, Mark I Mccarthy, Thomas Meitinger, Cristina Menni, Kyriaki Michailidou, Iona Y Millwood, Roger L Milne, Grant W Montgomery, Heli Nevanlinna, Ilja M Nolte, Dale R Nyholt, Nadia Obi, Katie M O'Brien, Kenneth Offit, Albertine J Oldehinkel, Sisse R Ostrowski, Aarno Palotie, Ole B Pedersen, Annette Peters, Giulia Pianigiani, Dijana Plaseska-Karanfilska, Anneli Pouta, Alfred Pozarickij, Paolo Radice, Gad Rennert, Frits R Rosendaal, Daniela Ruggiero, Emmanouil Saloustros, Dale P Sandler, Sabine Schipf, Carsten O Schmidt, Marjanka K Schmidt, Kerrin Small, Beatrice Spedicati, Meir Stampfer, Jennifer Stone, Rulla M Tamimi, Lauren R Teras, Emmi Tikkanen, Constance Turman, Celine M Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Babette S Zemel, Wei Zheng, Ko W Van Dijk, Behrooz Z Alizadeh, Stefania Bandinelli, Eric Boerwinkle, Dorret I Boomsma, Marina Ciullo, Georgia Chenevix-Trench, Francesco Cucca, Tõnu Esko, Christian Gieger, Struan F A Grant, Vilmundur Gudnason, Caroline Hayward, Ivana Kolčić, Peter Kraft, Deborah A Lawlor, Nicholas G Martin, Ellen A Nøhr, Nancy L Pedersen, Craig E Pennell, Paul M Ridker, Antonietta Robino, Harold Snieder, Ulla Sovio, Tim D Spector, Doris Stöckl, Cathie Sudlow, Nic J Timpson, Daniela Toniolo, André Uitterlinden, Sheila Ulivi, Henry Völzke, Nicholas J Wareham, Elisabeth Widen, James F Wilson, Lifelines Cohort Study, Danish Blood Donor Study, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Biobank Japan Project, China Kadoorie Biobank Collaborative Group, Paul D P Pharoah, Liming Li, Douglas F Easton, Pål R Njølstad, Patrick Sulem, Joanne M Murabito, Anna Murray, Despoina Manousaki, Anders Juul, Christian Erikstrup, Kari Stefansson, Momoko Horikoshi, Zhengming Chen, I Sadaf Farooqi, Nelly Pitteloud, Stefan Johansson, Felix R Day, John R B Perry, Ken K Ong

Faculty, Staff and Student Publications

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respectively. We identified several genes harboring rare loss-of-function variants in ~200,000 women, including variants in ZNF483, which abolished the impact of polygenic risk. Variant-to-gene mapping approaches and mouse gonadotropin-releasing hormone neuron RNA sequencing implicated 665 genes, including an uncharacterized G-protein-coupled receptor, GPR83, …


High Throughput Plasma Proteomics And Risk Of Heart Failure And Frailty In Late Life, Diego Ramonfaur, Leo F Buckley, Victoria Arthur, Yimin Yang, Brian L Claggett, Chiadi E Ndumele, Keenan A Walker, Thomas Austin, Michelle C Odden, James S Floyd, Sandra Sanders-Van Wijk, Joyce Njoroge, Jorge R Kizer, Dalane Kitzman, Suma H Konety, Jennifer Schrack, Fangyu Liu, B Gwen Windham, Priya Palta, Josef Coresh, Bing Yu, Amil M Shah Jul 2024

High Throughput Plasma Proteomics And Risk Of Heart Failure And Frailty In Late Life, Diego Ramonfaur, Leo F Buckley, Victoria Arthur, Yimin Yang, Brian L Claggett, Chiadi E Ndumele, Keenan A Walker, Thomas Austin, Michelle C Odden, James S Floyd, Sandra Sanders-Van Wijk, Joyce Njoroge, Jorge R Kizer, Dalane Kitzman, Suma H Konety, Jennifer Schrack, Fangyu Liu, B Gwen Windham, Priya Palta, Josef Coresh, Bing Yu, Amil M Shah

Faculty, Staff and Student Publications

Importance: Heart failure (HF) and frailty frequently coexist and may share a common pathobiology, although the underlying mechanisms remain unclear. Understanding these mechanisms may provide guidance for preventing and treating both conditions.

Objective: To identify shared pathways between incident HF and frailty in late life using large-scale proteomics.

Design, setting, and participants: In this cohort study, 4877 aptamers (Somascan v4) were measured among participants in the community-based longitudinal Atherosclerosis Risk In Communities (ARIC) cohort study at visit 3 (V3; 1993-1995; n = 10 638) and at visit 5 (V5; 2011-2013; n = 3908). Analyses were externally replicated among 3189 participants …


4. Administrative Policies, Services And Facilities, Saint Mary's College Of California Jul 2024

4. Administrative Policies, Services And Facilities, Saint Mary's College Of California

Faculty Handbook

No abstract provided.


Transgender Women With Suppressed Testosterone Display Lower Burden Of Coronary Disease Than Matched Cisgender Men, Jordan E Lake, Han Feng, Ana N Hyatt, Hongyu Miao, Paula Debroy, Nicholas Funderburg, Kate Ailstock, Adrian Dobs, Sabina Haberlen, Jared W Magnani, Joseph B Margolick, Kate Mcgowan, Frank J Palella, Mallory D Witt, Shalender Bhasin, Matthew J Budoff, Wendy S Post, Todd T Brown Jul 2024

Transgender Women With Suppressed Testosterone Display Lower Burden Of Coronary Disease Than Matched Cisgender Men, Jordan E Lake, Han Feng, Ana N Hyatt, Hongyu Miao, Paula Debroy, Nicholas Funderburg, Kate Ailstock, Adrian Dobs, Sabina Haberlen, Jared W Magnani, Joseph B Margolick, Kate Mcgowan, Frank J Palella, Mallory D Witt, Shalender Bhasin, Matthew J Budoff, Wendy S Post, Todd T Brown

Faculty, Staff and Student Publications

Context: Cardiovascular disease (CVD) in transgender women (TW) may be affected by gender-affirming hormone therapy (GAHT) and HIV, but few data compare TW on contemporary GAHT to well-matched controls.

Objective: We compared CVD burden and biomarker profiles between TW and matched cisgender men (CM).

Methods: Adult TW on GAHT (n = 29) were recruited for a cross-sectional study (2018-2020). CM (n = 48) from the former Multicenter AIDS Cohort Study were matched 2:1 to TW on HIV serostatus, age ±5 years, race/ethnicity, BMI category and antiretroviral therapy (ART) type. Cardiac parameters were measured by CT and coronary atherosclerosis by coronary …


Project Evergreen: Ai Weed Detection In A Usfs Conifer Nursery, Kevin Wing, John Shovic Jul 2024

Project Evergreen: Ai Weed Detection In A Usfs Conifer Nursery, Kevin Wing, John Shovic

Idaho Conference on Undergraduate Research

This research, conducted under Project Evergreen, aims to develop a computer vision-based solution to detect weeds in conifer sapling rows within a United States Forest Service (USFS) nursery. The presence of weeds in these rows significantly impacts seedling viability, posing a challenge to reforestation efforts. Leveraging advanced machine vision techniques, this study aims to enhance the precision and efficiency of weed management practices by identifying weeds in the field, thereby improving seedling survival rates. The YOLO v8 model was selected for its superior real-time capabilities and high accuracy. YOLO (You Only Look Once) is a single-pass convolutional neural network known …


The Prohibition Of Annexations And The Foundations Of Modern International Law, Ingrid W. Brunk, Monica Hakimi Jul 2024

The Prohibition Of Annexations And The Foundations Of Modern International Law, Ingrid W. Brunk, Monica Hakimi

Vanderbilt Law School Faculty Publications

The international legal norm that prohibits forcible annexations of territory is foundational to modern international law. It lies at the core of three projects that have been central to the enterprise: (1) to settle title to territory as the basis for establishing state authority; (2) to regulate the use of force across settled borders; and (3) to provide for people within settled borders collectively to determine their own fates. Prohibiting forcible annexations is integral to each of these projects independently, and by tying them together, has had a transformative effect on the legal system as a whole. However, its significance …


The Needless Search For A Founding-Era "Hearsay" Definition, Jeffrey Bellin Jul 2024

The Needless Search For A Founding-Era "Hearsay" Definition, Jeffrey Bellin

Vanderbilt Law School Faculty Publications

Modern Confrontation Clause doctrine permits only unconfronted "out-of-court statements that would have been admissible in a criminal case at the time of the founding." To operationalize this concept, the Supreme Court identifies "testimonial hearsay" as the Clause's primary concern. Its opinions regularly dive into the historical record to refine what counts as "testimonial" but ignore that record in defining "hearsay." This omission cannot last. Cases in the lower courts, and one on the Court's recent docket, concern testimonial but (arguably) non-hearsay statements. And while confrontation jurisprudence is supposed to be tied to founding-era evidence law, the "hearsay" definition, casually referenced …


The Effects Of Relational Human Resource Management: A Moderated Mediation Model Of Positive Affective Climate And Collective Occupational Calling, Pingshu Li, Yuanmei (Elly) Qu, Mengwei Li, Patrick E. Downes, Guofeng Wang Jul 2024

The Effects Of Relational Human Resource Management: A Moderated Mediation Model Of Positive Affective Climate And Collective Occupational Calling, Pingshu Li, Yuanmei (Elly) Qu, Mengwei Li, Patrick E. Downes, Guofeng Wang

Management Faculty Publications

Relationship-oriented human resource management (HRM) contributes to organizational functioning by promoting employee relationships, coordination, and cooperation. We propose unit-level positive affective climate as a motivational mechanism through which relationship-oriented HR systems can positively influence unit service quality and relationships with beneficiaries, and prevent individual emotional exhaustion. Moreover, we propose collective occupational calling serves as an alternative motivational source that can substitute for the positive effects of positive affective climate. In analyzing a sample composed of 742 nurses from 48 nursing units of two hospitals in China with data collection at three time points before and after the COVID-19 outbreak, our …


Assignment - Political Bullshit, Russ Wood Jul 2024

Assignment - Political Bullshit, Russ Wood

Civic Engagement & Voting Rights Teacher Scholars

No abstract provided.


Course Syllabus - The City As History: Introduction To Public History, Patricia Rutenberg Jul 2024

Course Syllabus - The City As History: Introduction To Public History, Patricia Rutenberg

Civic Engagement & Voting Rights Teacher Scholars

No abstract provided.


Course Syllabus - American Democracy A Draft Syllabus Outline For A University-Level, Advanced Undergraduate Course, Michael Landis Jul 2024

Course Syllabus - American Democracy A Draft Syllabus Outline For A University-Level, Advanced Undergraduate Course, Michael Landis

Civic Engagement & Voting Rights Teacher Scholars

No abstract provided.