Digital Commons Network^™

Young Driver Training And Socioeconomic Status: A Human-In-The-Loop Driving Simulator Evaluation, Jeffrey Edward Glassman

Psychology Theses & Dissertations

Previous research consistently shows that young drivers are poor at anticipating latent hazards on the roadway compared to more experienced drivers. The Road Awareness and Perception Training (RAPT) program is a driver training program that aims to accelerate young drivers’ learning of hazard anticipation (HA) skills. More recent research has started showing evidence that RAPT may be even more effective at reducing accidents for young drivers with a lower socioeconomic status (SES), though the direct impact of RAPT on HA skills in the driver population is yet unclear. The current experiment thus directly evaluated the effectiveness of RAPT on the …

Parallel-In-Time Implicit Schemes For Nonlinear Pdes, Subhash Paudel

Mathematics & Statistics Theses & Dissertations

An accurate prediction of unsteady physical phenomena arising in various applications (e.g., rotorcraft and turbomachinery flows, fluid-structure interaction, maneuvering flight conditions, etc.) requires a very large number of time steps, thus considerably increasing the total computational time, because conventional time integrators are inherently sequential. Parallel-in-time methods offer a promising direction for drastically reducing the computational time and achieving such scalability that is required for solving these unsteady problems on modern supercomputers with hundreds of thousands of computing cores. The parallel performance of existing parallel-in-time algorithms for nonlinear equations especially of the hyperbolic or mixed type is far from being satisfactory. …

The Impact Of Peer Observational Learning On Honesty Following A Transgression, Hannah M. Sliman

Psychology Theses & Dissertations

Parents and teachers concerns about the development and socialization of lying aligns with research suggesting that persistent lying is related with delinquency, aggression, and conduct problems. We were interested in examining the difference between two groups: Honest and Praise (HP), and Control Group (CG) for the extent to which exposure to the experimental condition influenced a child’s decision to be honest and confess after a transgression. The study was designed to examine the extent to which observing peers of similar age receiving praise for being honest can promote honesty amongst children. Further, the study determined if gender influences honest reporting. …

Associations Between Combat Exposure, Moral Injury, And Suicidality Among U.S. Military Members: The Moderating Impact Of Positive Rumination, Jeffrey M. Gabelmann

Psychology Theses & Dissertations

Numerous studies have documented the risk for suicide among recent-era veterans with combat experience. Recently, moral injury has emerged as a possible contributor to suicidality in veterans. To that end, no study has approached the combat exposure-moral injury-suicidality link with a focus grounded in positive psychology. Specifically, the present study explored whether positive rumination, or the reflection on positive emotions and moods, may buffer the deleterious effects of potentially traumatic experiences in warzones on moral injury and suicidality. This study was a secondary analysis of 250 current or former U.S. military members (M_age = 33.3 years) who had …

Decriminalizing Academia: Black First-Generation Community College Students In Unsatisfactory Academic Standing, Gerome Maurice Bell, Jr.

Educational Leadership & Workforce Development Theses & Dissertations

Community colleges serve as critical access points to higher education for Black students. However, current outcomes suggest that Black students are not being properly served in America’s community colleges. Although well-meaning institutional leaders often create policies and programs aimed at improving success rates for students from marginalized backgrounds, too often, the voices of those directly impacted by the policy are not considered. Consequently, little is known about the lived experiences of Black first-generation community college students, especially those in unsatisfactory academic standing. The purpose of this transcendental phenomenological study was to explore the lived experiences of Black first-generation students on …

Use Of Ultrasound For Identification Of Musculoskeletal Injury In Active Populations, Kathleen Karen Hogan

Rehabilitation Sciences Theses & Dissertations

Lower extremity tendinopathies and fasciopathy conditions are prevalent amongst sedentary individuals,^1,2 athletes,^3,4 elite runners,^5,6and military personnel⁷ and can lead to chronic disability and reduction in quality of life. ^8,9 Both tendinopathy and fasciopathy are thought to be mechanical in nature and caused by acute or chronic overloading leading to a disruption in the uniformity of the soft tissue structure. Ultrasound imaging has gained popularity in the last decade among many sports medicine clinicians to gain information regarding tissue structure for musculoskeletal injury (MKSI) management. Ultrasound imaging allows for the evaluation of in-vivo structures and at …

An Integrated Space Test Lexicon: A Taxonomy For The Integrated Test And Evaluation Of Space Systems, Stephen K. Tullino, Andrew S. Keys, Robert A. Bettinger, Amy M. Cox, David R. Jacques

Faculty Publications

The proposed Integrated Space Test Lexicon is intended to amalgamate the numerous definitions of integrated (IT or IT&E), development test (DT or DT&E), and operational test (OT or OT&E) into unified, service-wide definitions, aligned with the Space Test Enterprise Vision. Refining such definitions will help distill the core characteristics of these fundamental test types to first identify space system activities composing what is traditionally known as DT and OT, then to provide a means of how these activities fit into the IT paradigm and support space system development. In forging a common understanding of how DT and OT support space …

Automated Quantification Of Measurable Residual Disease In Chronic Lymphocytic Leukemia Using An Artificial Intelligence-Assisted Workflow, Alexandre Bazinet, Alan Wang, Xinmei Li, Fuli Jia, Huan Mo, Wei Wang, Sa A Wang

Faculty, Staff and Student Publications

Detection of measurable residual disease (MRD) in chronic lymphocytic leukemia (CLL) is an important prognostic marker. The most common CLL MRD method in current use is multiparameter flow cytometry, but availability is limited by the need for expert manual analysis. Automated analysis has the potential to expand access to CLL MRD testing. We evaluated the performance of an artificial intelligence (AI)-assisted multiparameter flow cytometry (MFC) workflow for CLL MRD. We randomly selected 113 CLL MRD FCS files and divided them into training and validation sets. The training set (n = 41) was gated by expert manual analysis and used to …

A Guide To Understanding Big Data For The Nurse Scientist: A Discursive Paper, Henry Ofori Duah, Samantha J. Boch, Sara Arter, Nichole Nidey, Joshua Lambert

College of Nursing Faculty Research and Publications

Big data refers to extremely large data generated at high volume, velocity, variety, and veracity. The nurse scientist is uniquely positioned to leverage big data to suggest novel hypotheses on patient care and the healthcare system. The purpose of this paper is to provide an introductory guide to understanding the use and capability of big data for nurse scientists. Herein, we discuss the practical, ethical, social, and educational implications of using big data in nursing research. Some practical challenges with the use of big data include data accessibility, data quality, missing data, variable data standards, fragmentation of health data, and …

Sharps Injuries Among Healthcare Workers In Liberia And Ghana: A Cross-Sectional Survey, Laura Jean Ridge, John Arko-Mensah, Josh Lambert, Lydia Aziato, G. Clinton Zeantoe, Henry Ofori Duah, Marjorie Mccullagh

College of Nursing Faculty Research and Publications

There are little data on sharps injuries among healthcare workers in West Africa despite the region’s high rate of hepatitis B and human immunodeficiency virus. The purpose of this study is to investigate healthcare workers’ history of sharps injuries in Liberia and Ghana. An electronic cross-sectional survey was conducted among healthcare workers in Liberia and Ghana from February to June 2022. A link to the survey was texted to participants through professional association membership lists, including nursing, midwifery, and physician assistant organizations in both Liberia and Ghana and a physician organization in Ghana only. Five hundred and nine participants reported …

Trauma- And Violence-Informed Empowering Care For Sexual Assault Survivors, L. B. Klein, Jessica Melnik, Kimberly Curran, Jeneile Luebke, Kaylen M. Moore, Ashley Ruiz, Cassilynn Brown, Diara Parker, Isabel Hernandez-White, Kate Walsh

College of Nursing Faculty Research and Publications

Background

Forensic nurse examiners, including sexual assault nurse examiners, provide care for survivors holistically through healthcare, emotional support, connection to follow-up care, safety planning, and, if desired, evidence collection to aid in the prosecution of sexual assault. There is increasing recognition that trauma-informed care must also include an understanding of the impacts of structural violence on minoritized patients to ensure health equity.

Aim

To help address this guidance gap, we expanded Campbell and colleagues' empowering care model using a trauma- and violence-informed care (TVIC) lens.

Methods

We used an iterative discussion-based process that included five joint meetings between a seven-member …

Corrigendum To "The Use Of Mr-Guided Radiation Therapy For Head And Neck Cancer And Recommended Reporting Guidance" Seminars In Radiation Oncology Volume 34 (2024) 69-83, Brigid A Mcdonald, Riccardo Dal Bello, Clifton D Fuller, Panagiotis Balermpas

Faculty, Staff and Student Publications

No abstract provided.

Epigenetic Regulation Of Heart Failure, Manisha Deogharia, Priyatansh Gurha

Faculty, Staff and Student Publications

Purpose of review: The studies on chromatin-modifying enzymes and how they respond to different stimuli within the cell have revolutionized our understanding of epigenetics. In this review, we provide an overview of the recent studies on epigenetic mechanisms implicated in heart failure.

Recent findings: We focus on the major mechanisms and the conceptual advances in epigenetics as evidenced by studies in humans and mouse models of heart failure. The significance of epigenetic modifications and the enzymes that catalyze them is also discussed. New findings from the studies of histone lysine demethylases demonstrate their significance in regulating fetal gene expression, as …

Emerging Cell And Molecular Targets For Treating Mucus Hypersecretion In Asthma, Ana M Jaramillo, Eszter K Vladar, Fernando Holguin, Burton F Dickey, Christopher M Evans

Faculty, Staff and Student Publications

Mucus provides a protective barrier that is crucial for host defense in the lungs. However, excessive or abnormal mucus can have pathophysiological consequences in many pulmonary diseases, including asthma. Patients with asthma are treated with agents that relax airway smooth muscle and reduce airway inflammation, but responses are often inadequate. In part, this is due to the inability of existing therapeutic agents to directly target mucus. Accordingly, there is a critical need to better understand how mucus hypersecretion and airway plugging are affected by the epithelial cells that synthesize, secrete, and transport mucus components. This review highlights recent advances in …

Cholesterol-Dependent Lxr Transcription Factor Activity Represses Pronociceptive Effects Of Estrogen In Sensory Neurons And Pain Induced By Myelin Basic Protein Fragments, Swathi K Hullugundi, Jennifer Dolkas, Andrei V Chernov, Tony L Yaksh, Kelly A Eddinger, Mila Angert, Glaucilene Ferreira Catroli, Alex Y Strongin, Patrick M Dougherty, Yan Li, Oswal Quehenberger, Aaron Armando, Veronica I Shubayev

Faculty, Staff and Student Publications

BACKGROUND: A bioactive myelin basic protein (MBP) fragment, comprising MBP

METHODS: In male and female normal and post-CCI rat sciatic nerves, we assessed: (i) cholesterol precursor and metabolite levels by lipidomics; (ii) MBP

RESULTS: CCI regulated LXRα ligand and receptor levels in nerves of both sexes, with cholesterol precursors, desmosterol and 7-DHC, and oxysterol elevated in females relative to males. MBP

CONCLUSION: The injury-released bioactive MBP fragments induce pronociceptive changes by selective inactivation of nuclear transcription factors, including LXRα. By Ncoa1 sequestration, bioactive MBP fragments render LXRα function to counteract pronociceptive activity of estrogen/ESR1 in sensory neurons. This effect of …

Tumor-Immune Signatures Of Treatment Resistance To Brentuximab Vedotin With Ipilimumab And/Or Nivolumab In Hodgkin Lymphoma, Edgar Gonzalez-Kozlova, Brad S Kahl, Et Al.

2020-Current year OA Pubs

UNLABELLED: To investigate the cellular and molecular mechanisms associated with targeting CD30-expressing Hodgkin lymphoma (HL) and immune checkpoint modulation induced by combination therapies of CTLA4 and PD1, we leveraged Phase 1/2 multicenter open-label trial NCT01896999 that enrolled patients with refractory or relapsed HL (R/R HL). Using peripheral blood, we assessed soluble proteins, cell composition, T-cell clonality, and tumor antigen-specific antibodies in 54 patients enrolled in the phase 1 component of the trial. NCT01896999 reported high (>75%) overall objective response rates with brentuximab vedotin (BV) in combination with ipilimumab (I) and/or nivolumab (N) in patients with R/R HL. We observed …

Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation In Melanoma: Impact Of Antibiotic Preconditioning On Microbiome And Immunity, Isabella C Glitza, Yongwoo David Seo, Christine N Spencer, Jennifer R Wortman, Elizabeth M Burton, Farah A Alayli, Christopher P Loo, Shikha Gautam, Ashish Damania, Julie Densmore, Justin Fairchild, Christopher R Cabanski, Matthew C Wong, Christine B Peterson, Brian Weiner, Nathan Hicks, John Aunins, Christopher Mcchalicher, Emily Walsh, Michael T Tetzlaff, Omid Hamid, Patrick A Ott, Genevieve M Boland, Ryan J Sullivan, Kenneth F Grossmann, Nadim J Ajami, Theresa Lavallee, Matthew R Henn, Hussein A Tawbi, Jennifer A Wargo

Faculty, Staff and Student Publications

Gut-microbiota modulation shows promise in improving immune-checkpoint blockade (ICB) response; however, precision biomarker-driven, placebo-controlled trials are lacking. We performed a multicenter, randomized placebo-controlled, biomarker-stratified phase I trial in patients with ICB-naïve metastatic melanoma using SER-401, an orally delivered Firmicutesenriched spore formulation. Fecal microbiota signatures were characterized at baseline; patients were stratified by high versus low Ruminococcaceae abundance prior to randomization to the SER-401 arm (oral vancomycin-preconditioning/SER-401 alone/nivolumab + SER-401), versus the placebo arm [placebo antibiotic/placebo microbiome modulation (PMM)/nivolumab + PMM (NCT03817125)]. Analysis of 14 accrued patients demonstrated that treatment with SER-401 + nivolumab was safe, with an overall response rate …

Progress And Challenges In Combating Corruption In Ukraine: Pathways Forward, Semen Kravtsov, Kostiantyn Orobets, Nataliia Shyshpanova, Oksana Vovchenko, Olena Berezovska-Chmil

Journal of Strategic Security

In the context of war, the issue of corruption in Ukraine and abuse of office attracts great attention from experts, scholars, and civil society. The article aims to highlight the dynamics of combating corruption in Ukraine. This includes its main challenges, achievements, and ways of overcoming them in the context of war. The paper employs analysis and synthesis methods to study the dynamics of combating corruption in Ukraine. The authors have reviewed reforms in various sectors to identify key achievements in each corruption risk area. The article highlights the key achievements in the dynamics of combating corruption in Ukraine during …

Video Games And Radical Movements: "Ein Prozent" And "Heimat Defender", Göksel Türker, Ali Gök

Journal of Strategic Security

The far-right, which poses a threat of escalating into terrorism or inciting violence, employs a variety of tactics to spread its ideologies among the general public. In this context, "Heimat Defender: Rebellion," a two-dimensional video game supported by the far-right Ein Prozent operating in Germany, draws attention. In the study, the game in question was examined on the far-right and especially Ein Prozent ideology and subjected to discourse analysis. The analysis revealed that the game plot was shaped according to the friend-enemy perception of Ein Prozent and the far-right. Accordingly, in the game in question, opposition to multiculturalism, immigration, globalism, …

Why Montana Should Amend Its Uniform Commercial Code, Jonathon S. Byington

Faculty Law Review Articles

This Article is about needed updates to Montana’s Uniform Commercial Code. The Uniform Commercial Code provides a structure of rules to facilitate commerce. This Article begins by explaining where the Uniform Commercial Code came from and when Montana enacted it. It then summarizes Montana’s historical amendments to its Uniform Commercial Code and points out a pattern of amendments following new industries or significant changes to existing industries. It highlights the development and expansion of multiple new industries related to e-commerce and cryptocurrency. It then walks through insufficient or outdated aspects of Montana’s Uniform Commercial Code and explains how the Uniform …

Impact Of Lifetime Stressor Exposure On Neuroenergetics In Schizophrenia Spectrum Disorders, Joshua Chiappelli, Anya Savransky, Yizhou Ma, Si Gao, Mark D Kvarta, Peter Kochunov, George M Slavich, L Elliot Hong

Faculty, Staff and Student Publications

N-acetylasparate and lactate are two prominent brain metabolites closely related to mitochondrial functioning. Prior research revealing lower levels of NAA and higher levels of lactate in the cerebral cortex of patients with schizophrenia suggest possible abnormalities in the energy supply pathway necessary for brain function. Given that stress and adversity are a strong risk factor for a variety of mental health problems, including psychotic disorders, we investigated the hypothesis that stress contributes to abnormal neuroenergetics in patients with schizophrenia. To test this hypothesis, we used the Stress and Adversity Inventory (STRAIN) to comprehensively assess the lifetime stressor exposure profiles of …

Paying A Heavy Price: Costs Of Care For People With Severe Obesity In Nursing Homes, Luisa Fernandez, Bianca Shieu, Alison Trinkoff, Nicholas Castle, David G Wolf, Steven Handler, John A Harris

Faculty, Staff and Student Publications

Background and objectives: The prevalence of resident obesity in nursing homes has increased dramatically from 22% to 28% between 2005 and 2015. To provide care for people with obesity, nursing homes have changed their admissions, staffing, and equipment, but underlying these changes are increased resources and financial costs of care. The purpose of this study is to describe nursing home organizational aspects of caring for older adults with obesity, with a focus on economic factors, from the perspective of nursing home staff and leadership.

Research design and methods: This qualitative study used descriptive approaches; data were collected through semistructured telephone …

Reinforcement Learning For Strategic Airport Slot Scheduling: Analysis Of State Observations And Reward Designs, Anh Nguyen-Duy, Duc-Thinh Pham, Jian-Yi Lye, Nguyen Binh Duong Ta

Research Collection School Of Computing and Information Systems

Due to the NP-hard nature, the strategic airport slot scheduling problem is calling for exploring sub-optimal approaches, such as heuristics and learning-based approaches. Moreover, the continuous increase in air traffic demand requires approaches that can work well in new scenarios. While heuristics rely on a fixed set of rules, which limits the ability to explore new solutions, Reinforcement Learning offers a versatile framework to automate the search and generalize to unseen scenarios. Finding a suitable state observation and reward structure design is essential in using Reinforcement Learning. In this paper, we investigate the impact of providing the Reinforcement Learning agent …

Commercial Motor Vehicles (Cmv) Drivers’ Behavior In Transition From Automated To Manual Driving In Highly Automated Vehicles (Level 4), Ali Riahisamani

Electronic Theses and Dissertations Archive

This dissertation comprises three studies focused on enhancing the safety of Commercial Motor Vehicle (CMV) drivers using a driving simulator to explore the effects of the transition from automated to manual driving in Highly Automated Vehicles (HAVs), Level 4 of autonomous vehicles. Although in HAVs the driving system is responsible for all driving tasks and even intervenes in some cases of critical events, the transition from automated to manual driving is still needed to complete the trip, especially if the system reaches its operational limits due to road conditions or unexpected system failure. This transition from automated to manual is …

Sulfur Hexafluoride Accumulation In Groundwaters Within Shelby County, Tennessee, Raka Sunderland

Electronic Theses and Dissertations Archive

Geochemical data from 2009-2023 for production wells in Shelby County, Tennessee, were analyzed to determine the origin of discrepancies in sulfur hexafluoride (SF6) results in relationship to other tracers and hydrogeologic characteristics of sampled wells. This study proposes three potential origins for the discrepancies: modern SF6 contamination introduced during sampling, contributions of terrigenic SF6 formation, and groundwater re-equilibration with modern air in the unsaturated zone. The results suggest contamination with modern air during sampling is significant in some settings. An airtight sampling method was developed and shown to be successful in reducing introduction of modern air during sampling. The results …

Energy Storage Systems Modeling And Optimization, Yogesh Nmn Manoharan

Electronic Theses and Dissertations Archive

In this dissertation, the presented research supports the energy transition from fossil fuels to clean energy through the optimization of sizing of energy storage systems, operational strategies, and renewable energy systems considering the uncertainties in atmospheric conditions. Towards this transition, maintaining stability between generation and demand is necessary due to the increasing renewable penetration, intermittency, and uncertainty. Maintenance of the stability between renewable energy generation and load is challenging because of varying resource availabilities, demand profiles, and economic factors in any given location. Though there are several techniques employed traditionally, here in this dissertation energy storage systems and demand side …

The Reliability Of Assessment During Learning, Blake Ryan Telfer

Electronic Theses and Dissertations Archive

Maximizing the efficiency of testing for learning is an important educational goal (Schellekens et al., 2021). According to Portela et al. (2017), educational efficiency is achieved when learning and test results are generated with minimal resources and high efficacy. Traditionally in classrooms, feedback from tests is provided after a test is finished. However, research on the testing effect (Kang et al., 2007; Rowland, 2014) and studies on assessment during feedback (Chang & Li, 2019) suggest that educational efficiency can be enhanced by providing immediate feedback after each response. Our goal is to investigate whether immediate feedback during assessment affects the …

Trajectories Of High Intensity Drinking In Emerging Adults: A Longitudinal Analysis Of Behavioral Economic Predictors And Alcohol Use Outcomes, Ulysses Carrillo Savage

Electronic Theses and Dissertations Archive

High-intensity drinking (HID; 8+/10+ drinks for women/men) is linked to higher BAC and negative alcohol-related consequences compared to heavy episodic drinking (HED; 4+/5+ drinks for women/men). This study used growth mixture modeling to identify HID trajectories, examined potential behavioral economic predictors (demand intensity, Omax, demand elasticity, and delayed reward discounting) of HID trajectory membership, and quantified associations between HID trajectories and alcohol-related outcomes (alcohol related consequences and life satisfaction). Participants were emerging adults from the community (N = 602; 42.7% male, 47.0% White, Black = 41.5%, Mage = 22.63) who reported recent heavy drinking at baseline. Assessments occurred every 4 …

Groundwater Recharge Estimation Focusing On Shallow Aquifer Dynamics In The Near Stream Zone Of The Incised Cub Creek, Middleton, Tennessee, Khayrun Nahar Mitu

Electronic Theses and Dissertations Archive

This study investigated the Lone Oaks restoration site in Middleton, Tennessee, focusing on Cub Creek's channeling issues. Subsurface investigations revealed a shallow aquifer with limited groundwater storage, varying in thickness by about 2 m between upstream (U/S) and downstream (D/S) sections, and an unsaturated zone extending from 1.8 m U/S to 2.3 m D/S. The underlying confining layer is 6.5 m bgs U/S and 9 m bgs D/S, indicating eastward erosion or deposition shift between the Wilcox and Porters Creek Clay. Where U/S and D/S soil moisture at 90 cm and 150 cm remained near saturation during the cool season, …

Targeting Histone Deacetylase 6 (Hdac6) To Enhance Radiation Therapy In Meningiomas In A 2d And 3d In Vitro Study, Juri Na, Shahana Shaji, C. Oliver Hanemann

Peninsula Medical School

Background: External radiation therapy (RT) is often a primary treatment for inoperable meningiomas in the absence of established chemotherapy. Histone deacetylase 6 (HDAC6) overexpression, commonly found in cancer, is acknowledged as a driver of cellular growth, and inhibiting HDACs holds promise in improving radiotherapeutic efficacy. Downregulation of HDAC6 facilitates the degradation of β-catenin. This protein is a key element in the Wnt/β-catenin signalling pathway, contributing to the progression of meningiomas. Methods: In order to elucidate the associations and therapeutic potential of HDAC6 inhibitors (HDAC6i) in conjunction with RT, we administered Cay10603, HDAC6i, to both immortalised and patient-derived meningioma cells prior …