Digital Commons Network^™

Self-Authorship In Teacher Candidates Learning To Create A Classroom Of Respect And Rapport, Jacqueline Grajera

Dissertations (1934 -)

ABSTRACT SELF-AUTHORSHIP IN TEACHER CANDIDATES LEARNING TO CREATE A CLASSROOM OF RESPECT AND RAPPORT Jacqueline Grajera Marquette University, 2024 Positive classroom climates set a foundation for equitable educational opportunities and, ultimately, social change (Whipp, 2013). This multi-modal two-phase study examined teacher candidate orientation of knowledge authority in creating a classroom environment marked by respectful relationships and genuine rapport at differing thresholds of field experience. Results of an adapted variation of Baxter Magolda and King’s (2001) Self-Authorship Survey (SAS) indicated that overall, when learning to cultivate a positive and supportive classroom environment, junior cohort study participants trusted the academia perspective of …

Intense, Repeated, And Ever-Present: An Initial Investigation Of Traumatic Invalidation Among Sexual Minorities, Zane Browning Ballard

Dissertations (1934 -)

Lesbian, gay, bisexual, and queer individuals have been shown to experience significantly more negative health outcomes than do heterosexuals, commonly attributed to sexual minority stress. Research to date has insufficiently explained the processes by which stigma exposure becomes felt, internalized stigma and has not accounted for resemblance between presentation of mental health effects of sexual minority stress and of post-traumatic responses. Researchers have posited traumatic invalidation may partially explain the development and manifestations of reactions to sexual minority stress. The current study proposed and tested a measure of traumatic invalidation, conceptualized as instances of interpersonal, identity-based invalidation among sexual minorities. …

Ypfs Lessons Learned Oral History Project: An Interview With Daniela Klingebiel, Daniela Klingebiel, Yasemin Sim Esmen

Documents

No abstract provided.

Sacred Heart University Magazine, Volume 5, Issue 2, Sacred Heart University

Sacred Heart University Magazine

No abstract provided.

Rising Tides: An Analytic Modeling Code Of Tidal Effects In Binary Neutron Star Mergers, Alexander O'Dell, Maria Babiuc-Hamilton

Physics Faculty Research

Gravitational waves produced by binary neutron star mergers offer a unique window into matter behavior under extreme conditions. In this context, we analytically model the effect of matter on gravitational waves from binary neutron star mergers. We start with a binary black hole system, leveraging the post-Newtonian formalism for the inspiral and the Backwards-one-Body model for the merger. We combine the two methods to generate a baseline waveform and we validate our results against numerical relativity simulations. Next, we integrate tidal effects in phase and amplitude to account for matter and spacetime interaction using the NRTidal model and test its …

Establishing Metrics To Encourage Broader Use Of Atomic Requirements – A Call For Exchange And Experimentation, William L. Honig

Computer Science: Faculty Publications and Other Works

There are seemingly many advantages to being able to identify, document, test, and trace single or “atomic” requirements during system development and maintenance. Ongoing work with Agile development has focused on “user stories” that can capture individual features for implementation. However, it is still difficult to evaluate the quality of such requirements and teaching their creation is difficult.

Based on a working definition of atomic requirement, this paper proposes a set of metrics for their evaluation. Ten metrics designed to measure atomic requirements are presented here: five used on individual requirements statements and five applied to a requirements document or …

Lost In Translation: A Qualitative Narrative Study On The Lived Experiences Of Bipoc Individuals With High-Functioning Autism Transitioning To College, Aiyeesha L. Hill

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Transitioning to college can prove overwhelming for BIPOC individuals with high-functioning autism (HF ASD) from low-income families (Accardo et al., 2019; Elias & White, 2018; Lambe et al., 2019). This qualitative study addressed the challenges these families faced or will face, fears and concerns about going to college, and the level of support received from high schools and postsecondary institutions, while determining if race and economic status have a bearing on access to information about transition planning. The methodology used for this study was a narrative design to gain insight into the lived experiences of this marginalized group and give …

Inpatient Staff Perspective On Verbal De-Escalation Within A High Acuity Population, Giovanna Dezutti

Dissertations

This study explored inpatient staff’s perspective of verbal de-escalation within a high acuity population as well as the factors that make either a positive or negative impact on the effectiveness of verbal de-escalation as used in high acuity impatient settings. This phenomenological study used semi-structured interviews of 5 participants working in this setting. Participants were recruited through snowball sampling, and interviews were conducted via zoom. This study found that participants unanimously agreed that the training they received regarding verbal de-escalation was not sufficient and that employment of certain personality traits and behaviors were more effective than using only the methods …

A Qualitative Study Exploring The Management & Implications Of Power Differentials Experienced By Pre-Licensed Supervisees In Clinical Supervision Settings, Joyti Jariwala

Dissertations

The focus in this qualitative study was to explore how power differentials in supervision create positive and negative experiences between licensed psychologists and pre-licensed doctoral students. The study results provide insight into how supervisees navigate these dynamics during supervision, which typically involves experiential learning environments in which trainees discuss progress, receive feedback, and enhance their skills. The theoretical framework grounding the study was social learning theory, which is based on the idea that individuals learn from modeling, observation, and imitation in a social context (Bandura, 1986). Reflexive thematic analysis was used to recognize similarities in findings gathered via two sets …

Identifying And Training Deep Learning Neural Networks On Biomedical-Related Datasets, Alan E. Woessner, Usman Anjum, Hadi Salman, Jacob Lear, Jeffrey T. Turner, Ross Campbell, Laura Beaudry, Justin Zhan, Lawrence E. Cornett, Susan Gauch, Kyle P. Quinn

Computer Science and Computer Engineering Faculty Publications and Presentations

This manuscript describes the development of a resources module that is part of a learning platform named 'NIGMS Sandbox for Cloud-based Learning' https://github.com/NIGMS/NIGMS-Sandbox. The overall genesis of the Sandbox is described in the editorial NIGMS Sandbox at the beginning of this Supplement. This module delivers learning materials on implementing deep learning algorithms for biomedical image data in an interactive format that uses appropriate cloud resources for data access and analyses. Biomedical-related datasets are widely used in both research and clinical settings, but the ability for professionally trained clinicians and researchers to interpret datasets becomes difficult as the size and …

The Role Of Apparatus In Problem-Solving And Model Construction And Contemplation, Maré E. Sutphen, Laura Ríos

Physics

Problem-solving serves a crucial role in learning physics, as it is required that students absorb laws, principles, and concepts and arrange their understanding in a structure accessible for application. Further, these arrangements necessarily include methods and strategies gained from past experience, required for the implementation of these structures. Although tedious, problem-solving requires not only the arrangement of knowledge, but the construction and contemplation of models of physical phenomena. Research shows that while amateur problem-solvers typically approach problems by stringing together equations, experts will first look at the larger picture of the physical phenomena at hand, and through a “series of …

Using Plithogenic Statistics To Determine Optimal Guinea Pig Manure Dosing In Prickly Pear Cultivation, Jorge F. Troya-Sarzosa, Cristian Oña

Neutrosophic Sets and Systems

This study applied plithogenic statistics to evaluate how different doses of guinea pig manure affect the cultivation of Opuntia ficus-indica (commonly known as prickly pear) and soil quality. It was determined that 7.5 tons/ha, referred to as treatment T3, is the optimal dose, as it maximizes the growth and production of the plant, improves plant height, and increases the production of buttons and berries. T3 also optimized organic matter and adjusted the pH to ideal levels, maintaining a nutritional balance that ensures the availability of nitrogen, phosphorus, and potassium. This balance enhances agricultural production without sacrificing soil sustainability. In conclusion, …

Unm Pathology, Pathfinder Summer 2024, Unm Department Of Pathology

Newsletters

No abstract provided.

Integrating Remote Sensing And Machine Learning To Determine Past, Current And Future Crop Water Use From The Nubian Sandstone Aquifer System, Moaz Ishag

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

The agriculture sector is a significant consumer of water, and sustainable water use begins with monitoring irrigated land. Delineating irrigated land supports decision-makers and promotes the sustainable use of this crucial resource. This study focuses on the Nubian Sandstone Aquifer System (NSAS), the largest aquifers in the world, which spans Egypt, Sudan, Libya, and Chad. The study aims to: 1) quantify the increase in irrigated hectares (both pivot and non-pivot) from 2000-2001 to 2023-2024; 2) identify major irrigated crop types and their water requirements; and 3) quantify groundwater crop water use from the NSAS using remote sensing via the Google …

Formalizing The Santa Fe Water Bank, Walker Williamson

Water Resources Professional Project Reports

Water users depend on institutional flexibility to efficiently allocate water in legally constrained and overallocated basins. Adaptive market-based mechanisms such as water banking proffer flexibility and fairness, but often face practical challenges fueled by empirical and institutional uncertainties. The Santa Fe Water Bank is a case in point. The City of Santa Fe transfers agricultural water rights from the Middle Rio Grande to its municipal Water Bank for sustainable development. Combined uncertainties in this process can obscure latent changes in water balance and foster misunderstanding, potentially provoking transfer protests. This study develops a formal model clarifying the interrelated institutional and …

Structural Analysis Of Dj-1 Glyoxalase Activity By Mix-And-Inject Serial Synchrotron Crystallography, Coleman Dolamore

Department of Biochemistry: Dissertations, Theses, and Student Research

Observing enzyme structures while they are catalyzing a reaction has been a major goal of both enzymology and structural biology for decades. With the advent of time-resolved serial X-ray crystallography using X-ray free electron lasers (XFELs) and synchrotron sources, enzyme reactions can be monitored in real time in crystallo. Here, we use two different approaches to study related enzymes involved in methylglyoxal detoxification. For human DJ-1, we used pink beam mix-and-inject serial crystallography (MISC) at the Advanced Photon Source (BioCARS 14-ID) to probe the controversial mechanism of DJ-1’s action on methylglyoxal by using serial Laue diffraction. The high flux …

Elucidation Of Potential Antimicrobial Properties Of Chalcones, Caleb Howell

Theses

The rise of antibiotic-resistant bacteria is a growing concern for the medical and biological community. Increased use of antibiotics has led to increased development of bacterial tolerances. This phenomenon, driven by the principles of evolution, has been exacerbated by the improper antibiotic use of these antibiotics. Often, individuals stop taking antibiotics once symptoms subside, mistakenly believing the infection is cured. This practice allows bacteria or fungi to develop resistance.

These antibiotics have been developed from secondary metabolites. While we have many effective antibiotics we are facing new threats. Chalcones are being looked at for their potential in addressing this issue. …

"No One Likes Us, We Don't Care": The Legality Of Ticket Bans On Opposing Fans, Rebecca Black

Jeffrey S. Moorad Sports Law Journal (1994 - )

No abstract provided.

Reliability Of The Cvms Method To Assess The Craniofacial Growth Spurt, Holly Ingersoll

Master's Theses (2009 -)

Objective: Cervical vertebral maturation staging (CVMS) is a popular method to determine the growth potential of a child utilizing the changing shapes of C2, C3, and C4. Staging is separated into six stages where the first two stages are before the growth spurt, the second two stages are during the growth spurt, and the last two stages are after the growth spurt. This method is highly practical because it is read on a lateral cephalogram, a radiograph taken by the orthodontist for diagnostic records. However, many clinicians question its reliability and validity as a test. The objective of this study …

Design And Verification Of A Planar, Programmable, Compliant Hand For Use In General Open-Loop Constrained Manipulation, Jacob Frye

Master's Theses (2009 -)

Conventional robots are adept at performing tasks where the desired absolute position of the robot's end effector is well defined. However, these robots will struggle with tasks in which the desired position is poorly defined, subject to variation, or determined by contact with a constraint with positional uncertainty. This problem can be solved by introducing compliance to the system, either active or passive. Active compliance uses force feedback to make corrective motions, but is limited in speed and experiences higher contact forces than passive systems. Passively compliant systems are capable of realizing the necessary compliance for a given task but …

Theoretical And Experimental Evaluation Of The Electronic Relaxation Mechanisms Of 2-Pyrimidinone: The Primary Uva Absorbing Moiety Of The Dna And Rna (6–4) Photolesion, Sean J. Hoehn, Sarah E. Krul, Carlos E. Crespo-Hernández

Faculty Scholarship

The (6–4) photolesion is a key photodamage that occurs when two adjacent pyrimidine bases in a DNA strand bond together. To better understand how the absorption of UVB and UVA radiation by the 2-pyrimidinone moiety in a (6–4) lesion can damage DNA, it is important to study the electronic deactivation mechanism of its 2-pyrimidinone chromophore. This study employs theoretical (MS-CASPT2/cc-pVDZ level) and experimental (steady state and femtosecond broadband spectroscopic) methods to elucidate the photochemical relaxation mechanisms of 2-(1H)-pyrimidinone and 1-methyl-2-(1H)-pyrimidinone in aqueous solution (pH 7.4). In short, excitation at 320 nm leads to the population of the S1¹(ππ*) …

Impact Of Non-Thermal Plasma Generated Using Air And Nitrogen On Functional Properties Of Milk Protein Dispersions, Nikitha Modupalli, Md Mahfuzur Rahman

Food Science Faculty Publications and Presentations

This study focuses on improving the functionalities of milk protein concentrate (MPC) using a nonthermal plasma jet and plasma-activated water (PAW) with atmospheric air and nitrogen as source gases. The 5% and 10% MPC dispersions were directly treated with a plasma jet, and PAW was used to make the MPC dispersions. The dispersions were analyzed for changes in protein structure and functional properties. The treatment altered the secondary structure of MPC protein structure by increasing β-components and changing the order of random coils. The solubility of the PAW-treated 5% protein dispersions doubled due to plasma-induced modification of hydrophilic and covalent …

Fedgmmat: Federated Generalized Linear Mixed Model Association Tests, Wentao Li, Han Chen, Xiaoqian Jiang, Arif Harmanci

Faculty, Staff and Student Publications

Increasing genetic and phenotypic data size is critical for understanding the genetic determinants of diseases. Evidently, establishing practical means for collaboration and data sharing among institutions is a fundamental methodological barrier for performing high-powered studies. As the sample sizes become more heterogeneous, complex statistical approaches, such as generalized linear mixed effects models, must be used to correct for the confounders that may bias results. On another front, due to the privacy concerns around Protected Health Information (PHI), genetic information is restrictively protected by sharing according to regulations such as Health Insurance Portability and Accountability Act (HIPAA). This limits data sharing …

Ultrapotent Broadly Neutralizing Human-Llama Bispecific Antibodies Against Hiv-1, Jianliang Xu, Tongqing Zhou, Krisha Mckee, Baoshan Zhang, Cuiping Liu, Alexandra F Nazzari, Amarendra Pegu, Chen-Hsiang Shen, Jordan E Becker, Michael F Bender, Payton Chan, Anita Changela, Ridhi Chaudhary, Xuejun Chen, Tal Einav, Young Do Kwon, Bob C Lin, Mark K Louder, Jonah S Merriam, Nicholas C Morano, Sijy O'Dell, Adam S Olia, Reda Rawi, Ryan S Roark, Tyler Stephens, I-Ting Teng, Emily Tourtellott-Fogt, Shuishu Wang, Eun Sung Yang, Lawrence Shapiro, Yaroslav Tsybovsky, Nicole A Doria-Rose, Rafael Casellas, Peter D Kwong

Faculty, Staff and Student Publications

Broadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV‐1, but their potency and breadth are less than optimal. This study describes the immunization of a llama with the prefusion‐stabilized HIV‐1 envelope (Env) trimer, BG505 DS‐SOSIP, and the identification and improvement of potent neutralizing nanobodies recognizing the CD4‐binding site (CD4bs) of vulnerability. Two of the vaccine‐elicited CD4bs‐targeting nanobodies, G36 and R27, when engineered into a triple tandem format with llama IgG2a‐hinge region and human IgG1‐constant region (G36×3‐IgG2a and R27×3‐IgG2a), neutralized 96% of a multiclade 208‐strain panel at geometric mean IC80s of 0.314 and 0.033 µg mL−1, respectively. Cryo‐EM …

Phase 1 Dose Escalation Study Of The Mdm2 Inhibitor Milademetan As Monotherapy And In Combination With Azacitidine In Patients With Myeloid Malignancies, Courtney D Dinardo, Rebecca Olin, Eunice S Wang, Barry Skikne, Joseph Rosenthal, Prasanna Kumar, Hiroyuki Sumi, Yoshiyuki Hizukuri, Ying Hong, Parul Patel, Takahiko Seki, Tao Duan, Arnaud Lesegretain, Michael Andreeff

Faculty, Staff and Student Publications

BACKGROUND: Mouse double minute-2 homolog (MDM2) plays a key role in downregulating p53 activity in hematologic malignancies, and its overexpression is associated with poor outcomes.

METHODS: This phase 1 study assessed the safety and efficacy of different dosing regimens of the MDM2 inhibitor milademetan as monotherapy and in combination with azacitidine (AZA) in patients with relapsed or refractory acute myeloid leukemia or high-risk myelodysplastic syndromes.

RESULTS: Seventy-four patients (monotherapy, n = 57; milademetan-AZA combination, n = 17) were treated. The maximum tolerated dose of milademetan was 160 mg once daily given for the first 14-21 days of 28-day cycles as …

A Deep Catalogue Of Protein-Coding Variation In 983,578 Individuals, Kathie Y Sun, Xiaodong Bai, Siying Chen, Suying Bao, Chuanyi Zhang, Manav Kapoor, Joshua Backman, Tyler Joseph, Evan Maxwell, George Mitra, Alexander Gorovits, Adam Mansfield, Boris Boutkov, Sujit Gokhale, Lukas Habegger, Anthony Marcketta, Adam E Locke, Liron Ganel, Alicia Hawes, Michael D Kessler, Deepika Sharma, Jeffrey Staples, Jonas Bovijn, Sahar Gelfman, Alessandro Di Gioia, Veera M Rajagopal, Alexander Lopez, Jennifer Rico Varela, Jesús Alegre-Díaz, Jaime Berumen, Roberto Tapia-Conyer, Pablo Kuri-Morales, Jason Torres, Jonathan Emberson, Rory Collins, Regeneron Genetics Center, Rgc-Me Cohort Partners; Michael Cantor, Michael Cantor, Timothy Thornton, Hyun Min Kang, John D Overton, Alan R Shuldiner, M Laura Cremona, Mona Nafde, Aris Baras, Gonçalo Abecasis, Jonathan Marchini, Jeffrey G Reid, William Salerno, Suganthi Balasubramanian

Faculty, Staff and Student Publications

Rare coding variants that substantially affect function provide insights into the biology of a gene1-3. However, ascertaining the frequency of such variants requires large sample sizes4-8. Here we present a catalogue of human protein-coding variation, derived from exome sequencing of 983,578 individuals across diverse populations. In total, 23% of the Regeneron Genetics Center Million Exome (RGC-ME) data come from individuals of African, East Asian, Indigenous American, Middle Eastern and South Asian ancestry. The catalogue includes more than 10.4 million missense and 1.1 million predicted loss-of-function (pLOF) variants. We identify individuals with rare biallelic pLOF variants in 4,848 genes, 1,751 of …

Mutation Order In Acute Myeloid Leukemia Identifies Uncommon Patterns Of Evolution And Illuminates Phenotypic Heterogeneity, Matthew Schwede, Katharina Jahn, Jack Kuipers, Linde A Miles, Robert L Bowman, Troy Robinson, Ken Furudate, Hidetaka Uryu, Tomoyuki Tanaka, Yuya Sasaki, Asiri Ediriwickrema, Brooks Benard, Andrew J Gentles, Ross Levine, Niko Beerenwinkel, Koichi Takahashi, Ravindra Majeti

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) has a poor prognosis and a heterogeneous mutation landscape. Although common mutations are well-studied, little research has characterized how the sequence of mutations relates to clinical features. Using published, single-cell DNA sequencing data from three institutions, we compared clonal evolution patterns in AML to patient characteristics, disease phenotype, and outcomes. Mutation trees, which represent the order of select mutations, were created for 207 patients from targeted panel sequencing data using 1 639 162 cells, 823 mutations, and 275 samples. In 224 distinct orderings of mutated genes, mutations related to DNA methylation typically preceded those related to …

Juvenile Report, July 2024, Tennessee. Department Of Correction.

Juvenile Reports

No abstract provided.

Transcranial Direct Current Stimulation Of The Dorsolateral Prefrontal Cortex Does Not Improve Handgrip Time-To-Failure Or Alter Central Or Peripheral Hemodynamics, Yousef Qadumi

All NMU Master's Theses

Age-related deviations to the neuromuscular system negatively impact motor function and performance. Transcranial direct current stimulation (tDCS) has been linked to improvements in the neuromuscular system. The purpose of this study was to determine if tDCS delivered to the dorsolateral prefrontal cortex (DLPFC) would improve handgrip time-to-failure in adults 60 years old and older. Twenty-five participants completed five maximal voluntary contractions, followed by 20-minutes of a-tDCS or SHAM conditions. Next, participants completed a handgrip time-to-failure task by maximally squeezing an electronic handgrip dynamometer until they could no longer maintain 50% of their maximal voluntary contraction. Pairwise t-test revealed a non-significant …

Jme 4110: Patient Mat Mover, Muhammad Mughal, Seth Gallamore, Gabriel Monte, Marcos Navas Gallardo, Jamie Barvian

Washington University / UMSL Mechanical Engineering Design Project JME 4110

The idea of an improved patient mat mover was suggested to help make the life of patients and their care givers easier. The typical method of using brute force to lift a patient and slide a mat under them can be very challenging and tasking on both the patient and their care giver. It is a large inconvenience in the medical field and makes the process of patient care difficult and uncomfortable. Our value is designing a solution that will eliminate pain and difficulty for both our patients and their nurses/care givers by simplifying patient transport from bed to bed. …