Digital Commons Network^™

Effects Of Measurement Error In Student Pre-Post Test Score On The Recovery Of The Estimates Of Teachers Value-Added Scores, Merlin J. Kamgue

Graduate Theses and Dissertations

Abstract Background: Value-added models (VAMs) are statistical tools used to gauge a teacher’s impact on student performance by analyzing standardized test scores. These models project students’ future performance based on past scores and compare the projection to actual outcomes, accounting for differences in student backgrounds. However, the standard error of measurement (SEM) inherent in all measurement tools is often overlooked in VAMs. Aims and Objectives: This study aims to investigate the impact of test reliability on teacher and school score estimates within a Bayesian framework. We will precisely manipulate the reliability of standardized tests by adjusting the standard error of …

The Impact Of Algorithmic Control And Algorithmic Management In Online Labor Platforms, Yaping Zhu

Graduate Theses and Dissertations

Online labor platforms (OLPs) are transforming the way organizations operate and how people work. Platform work has been characterized as promoting autonomy and flexibility. Workers interact with a platform rather than human managers to accomplish tasks and they have the freedom to decide when, where, and how much to work. Yet, platform workers increasingly bemoan working conditions, revealing that the expected autonomy and flexibility benefits of platform work have not materialized. Current IS research sheds light on this phenomenon by explaining that platform organizations use algorithms to manage and control workers (i.e., algorithmic control). Yet, our understanding of how algorithmic …

Integrated Public Archeology: Innovative Three-Dimensional Modeling And Digital Storytelling Techniques For Historic Preservation And Outreach, Bryce James Drachenberg

Graduate Theses and Dissertations

This thesis investigates the integration of digital methodologies in public archeology to enhance public engagement and historic preservation. Focusing on digital storytelling and three-dimensional modeling, the research demonstrates how tools like photogrammetry and ArcGIS StoryMaps can democratize archeological knowledge and involve wider audiences. A case study of Cane Hill, Arkansas, showcases the practical application of these techniques. The study highlights the creation of three-dimensional models and their integration into interactive StoryMaps, discussing the benefits, challenges, and future directions of digital public archeology.

To Be Framed: Investigating The Influence Of American Media Frames On Gun Control, William C. Chamblee

Graduate Theses and Dissertations

Gun control may be one of the most polarizing political issues facing America today. While there are many factors that contribute to gun control controversy, one may be how it is framed by news organizations. Research suggests that the emergence of partisan news media, differing levels of issue salience, and the public’s increased willingness to selectively expose could widen the gap between both Republicans and Democrats through their opinions on the issue of gun control, causing polarization. Using a survey, this study found that both Republicans and Democrats are likely to selectively expose to partisan media outlets and that a …

Development Of A High-Throughput Screening Platform To Profile Gene Delivery And Transcriptional Control In Macrophages, Alexis Ivy

Graduate Theses and Dissertations

Macrophages are an important cell type in the body responsible for orchestrating the inflammatory response and return to homeostasis. Macrophages are often implicated in a multitude of disease pathologies including delayed wound healing, excessive fibrosis, autoimmune disease, and immunosuppression within the tumor microenvironment. Although macrophages have been targeted for therapeutic applications, success in utilizing them has remained elusive due to their relative ease of phenotype switching between inflammatory and anti-inflammatory. The challenge that remains is developing clinically relevant delivery vehicles that can target macrophages without causing a phenotypic switch counter-productive to the desired response. This is especially important when targeting …

Strategies For Misinformation Correction: Evidence For The Power Of Negation, Angel Houts

Graduate Theses and Dissertations

The current study investigated the effectiveness of different correction strategies for misinformation using a 2 (Source: no source, credible source) x 2 (Structure: negation, affirmation) within-subjects design with an additional control condition that had no corrections. Participants read 40 Twitter-like statements, which included 25 pieces of misinformation and 15 truthful statements, and rated their emotional responses on a Likert scale. After completing a distractor task, participants read additional Twitter-like statements across five different conditions. The first four conditions aimed to correct misinformation: negation with a credible source, negation without source, affirmation with a credible source, affirmation without source. The fifth …

Philippines : Why Increase In Research And Development (R&D) For Agriculture And Fisheries Is Needed?, Rico Ancog, Juan Pulhin, Elpidio Agbisit, Eufemio Rasco, Nathaniel Bantayan, Jose V. Camacho Jr., Philippe Guizol, Mercedita Sombilla

Journal Article

No abstract provided.

Intrinsic Universality In Tile Automata And Related Results, Elise C. Grizzell

Theses and Dissertations

The Tile Automata (TA) model describes self-assembly systems in which monomers can build structures and transition with an adjacent monomer to change their states. This paper shows that seeded TA is a non-committal intrinsically universal model of self-assembly. We present a single universal Tile Automata system containing approximately 4600 states that can simulate (a) the output assemblies created by any other Tile Automata system Γ, (b) the dynamics involved in building Γ’s assemblies, and (c) Γ’s internal state transitions. It does so in a non-committal way: it preserves the full non-deterministic dynamics of a tile’s potential attachment or transition by …

A Retrospective Quantitative Investigation Into Prostate Radiation Treatment Among Patients With Rectal Gas At Simulation, And How It Affects Planning: A South Florida Context., Soufiane Mansouri

Masters Projects

This study examines the effect of Hounsfield Unit (HU) correction of air in rectal tissue on dose distribution during prostate cancer radiation therapy planning. Ten patients treated between 2023 and 2024, of which received 70 Gray (Gy) in 28 fractions, were retrospectively analyzed. Inclusion criteria included the presence of rectal gas during simulation and noncompliance with pre-simulation preparation instructions. Statistical tests, including a standard t-test and a sign test, were used to compare dose planning without HU correction to planning with HU-corrected rectal gas to tissue, focusing on differences in rectal doses and planned target volume doses. Radiation therapy plans …

Expressing Distance In Graphs Of Functions In The Cartesian Plane: Obstacles And Interventions, Erika David Parr, Samuel Lippe

The Mathematics Enthusiast

Connecting algebraic and graphical representations encompasses a large portion of mathematical activity for students in grades 8-14. In Calculus, the ability to represent distances on graphs using algebraic expressions is foundational for a wide range of results. However, research has shown that students may struggle to make such connections. In this article, we seek to answer the following questions: (1) What are the underlying conceptions critical to expressing distances on graphs of functions algebraically? and (2) What types of tasks may support students in developing this skill? We first offer a conceptual analysis of the connections between algebraic expressions and …

Connecting Representations And Ways Of Thinking About Slope From Algebra To Calculus, Deborah Moore-Russo, Courtney Nagle

The Mathematics Enthusiast

While slope is a topic in the algebra curriculum, having a robust understanding of slope is needed for students to truly understand several single and multivariable calculus topics with any depth. We begin with a review of the topic of slope and present what is known from its existing corpus of literature. We then outline the tenets of APOS theory. Building from there, we suggest what a robust, flexible understanding of slope involves, as well as how slope is used, with the APOS-slope framework acting as a theoretical lens. This is followed by the cases of two hypothetical students built …

A Randomised, Parallel-Group, Double-Blind, Placebo-Controlled Phase 3 Study To Determine The Effectiveness Of The Type I Interferon Receptor Antibody, Anifrolumab, In Systemic Sclerosis: Daisy Study Design And Rationale, Dinesh Khanna, Christopher P Denton, Shervin Assassi, Masataka Kuwana, Yannick Allanore, Robyn T Domsic, Christi Kleoudis, John Xu, Eszter Csomor, Caroline Seo, Marius Albulescu, Raj Tummala, Hussein Al-Mossawi, Rubana N Kalyani, Francesco Del Galdo

Faculty, Staff and Student Publications

Objectives: The type I interferon pathway is a promising target for treatment of patients with systemic sclerosis (SSc). Here, we describe the design of a multinational, randomised phase 3 study to Determine the effectiveness of the type I interferon receptor antibody, Anifrolumab, In SYstemic sclerosis (DAISY).

Methods: DAISY includes a 52-week double-blind, placebo-controlled treatment period, a 52-week open-label active treatment period, and a 12-week safety follow-up period. The patient population includes a planned 306 adults with limited or diffuse cutaneous active SSc who satisfied American College of Rheumatology/European Alliance of Associations for Rheumatology 2013 SSc criteria. Use of standard immunosuppressants, …

Privacy-Preserving Model Evaluation For Logistic And Linear Regression Using Homomorphically Encrypted Genotype Data, Seungwan Hong, Yoolim A Choi, Daniel S Joo, Gamze Gürsoy

Faculty, Staff and Student Publications

Objective: Linear and logistic regression are widely used statistical techniques in population genetics for analyzing genetic data and uncovering patterns and associations in large genetic datasets, such as identifying genetic variations linked to specific diseases or traits. However, obtaining statistically significant results from these studies requires large amounts of sensitive genotype and phenotype information from thousands of patients, which raises privacy concerns. Although cryptographic techniques such as homomorphic encryption offers a potential solution to the privacy concerns as it allows computations on encrypted data, previous methods leveraging homomorphic encryption have not addressed the confidentiality of shared models, which can leak …

The Effects Of Non-Invasive Brain Stimulation On Excitability Of The Primary Motor Cortices And Complex Motor Task Learning, Erik Woodruff Wilkins

UNLV Theses, Dissertations, Professional Papers, and Capstones

Transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) are promising non-invasive brain stimulation techniques, particularly for clinical applications involving altered or impaired motor function, such as in stroke and Parkinson’s disease. Although tDCS and tACS are different modalities, both forms of stimulation operate on the same principle - weak electrical currents are delivered through electrodes placed on the scalp in specific configurations known as “montages”. The most commonly used montage for targeting the primary motor cortex (M1) is the M1-SO configuration. This montage leverages the established observation that cortical regions directly beneath the anode generally increase in …

Serl: Style-Embedding Representation Learning For Unsupervised Ct Images Synthesis From Unpaired Mr Images, Lei You, Hongyu Wang, Eduardo J Matta, Venkateswar Surabhi, Xiaobo Zhou

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and the fastest-growing cause of cancer deaths in the United States. Computed tomography (CT) and magnetic resonance (MR) imaging are the key image-based examination methods for HCC patients. Patients may alternatively undergo CT and MR exams given a radiation dose of the former and the cost of the latter. Due to organ representation differences between CT and MR, it's a great challenge to detect the tumors from a time series of data consisting of both CT and MR by a single model. The annotations for these time series …

Trauma-Related Cognitions And Discrimination As Predictors Of Maladaptive Coping Among Marginalized Maltreated Youth, Shadie Burke

UNLV Theses, Dissertations, Professional Papers, and Capstones

Maltreated youth are at an increased risk for engaging in direct or indirect self-injurious behavior to cope with the aftereffects of a traumatic event. These behaviors are often associated with negative health outcomes, substance use and premature death. Existing research proposes a link between child maltreatment and indirect self-harm but the mechanism into why this occurs is unclear. The present study examined two key research questions: (1) which specific trauma-related cognitions, sexual identity and cultural factors predict direct self-injurious behavior (previous suicide attempt(s) and NSSI) among marginalized maltreated youth?; and (2) which specific trauma-related cognitions, sexual identity and cultural factors …

Molecular Pathways And Cellular Subsets Associated With Adverse Clinical Outcomes In Overlapping Immune-Related Myocarditis And Myositis, Bilal A Siddiqui, Nicolas L Palaskas, Sreyashi Basu, Yibo Dai, Zhong He, Shalini S Yadav, James P Allison, Rahul A Sheth, Sudhakar Tummala, Maximilian Buja, Meenakshi B Bhattacharjee, Cezar Iliescu, Anishia Rawther-Karedath, Anita Deswal, Linghua Wang, Padmanee Sharma, Sumit K Subudhi

Faculty, Staff and Student Publications

Immune checkpoint therapies (ICT) can induce life-threatening immune-related adverse events, including myocarditis and myositis, which are rare but often concurrent. The molecular pathways and immune subsets underlying these toxicities remain poorly understood. To address this need, we performed single-cell RNA sequencing of heart and skeletal muscle biopsies obtained from living patients with cancers treated with ICTs and admitted to the hospital with myocarditis and/or myositis (overlapping myocarditis plus myositis, n = 10; myocarditis-only, n = 1) or ICT-exposed patients ruled out for toxicity utilized as controls (n = 9). All biopsies were obtained within 96 hours of clinical presentation. Analyses …

Can Anorectal Stenosis Be Managed With Dilations Alone? A Pcplc Review., Zoe M. Saenz, Kelly Austin, Jeffrey R. Avansino, Andrea Badillo, Casey M. Calkins, Megan M. Durham, Megan K. Fuller, Ankur Rana, Ron W. Reeder, Rebecca M. Rentea, Michael D. Rollins, K Elizabeth Speck, Richard J. Wood, Jamie C. Harris, Jamie Anderson, Maheen Hassan, Payam Saadai, Pediatric Colorectal And Pelvic Learning Consortium (Pcplc)

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Congenital anorectal stenosis is managed by dilations or operative repair. Recent studies now propose use of dilations as the primary treatment modality to potentially defer or eliminate the need for surgical repair. We aim to characterize the management and outcomes of these patients via a multi-institutional review using the Pediatric Colorectal and Pelvic Learning Consortium (PCPLC) registry.

METHODS: A retrospective database review was performed using the PCPLC registry. The patients were evaluated for demographics, co-morbidities, diagnostic work-up, surgical intervention, current bowel management, and complications.

RESULTS: 64 patients with anal or rectal stenosis were identified (57 anal, 7 rectal) from …

Inhibition Of Lysine Acetyltransferase Kat6 In Er+Her2− Metastatic Breast Cancer: A Phase 1 Trial, Toru Mukohara, Yeon Hee Park, David Sommerhalder, Kan Yonemori, Erika Hamilton, Sung-Bae Kim, Jee Hyun Kim, Hiroji Iwata, Toshinari Yamashita, Rachel M Layman, Monica Mita, Timothy Clay, Yee Soo Chae, Catherine Oakman, Fengting Yan, Gun Min Kim, Seock-Ah Im, Geoffrey J Lindeman, Hope S Rugo, Marlon Liyanage, Michelle Saul, Christophe Le Corre, Athanasia Skoura, Li Liu, Meng Li, Patricia M Lorusso

Faculty, Staff and Student Publications

Inhibition of histone lysine acetyltransferases (KATs) KAT6A and KAT6B has shown antitumor activity in estrogen receptor-positive (ER+) breast cancer preclinical models. PF-07248144 is a selective catalytic inhibitor of KAT6A and KAT6B. In the present study, we report the safety, pharmacokinetics (PK), pharmacodynamics, efficacy and biomarker results from the first-in-human, phase 1 dose escalation and dose expansion study (n = 107) of PF-07248144 monotherapy and fulvestrant combination in heavily pretreated ER+ human epidermal growth factor receptor-negative (HER2−) metastatic breast cancer (mBC). The primary objectives of assessing the safety and tolerability and determining the recommended dose for expansion of PF-07248144, as …

Pharmacodynamic Activity Of [18f]-Fluorthanatrace Poly(Adp-Ribose) Polymerase Positron Emission Tomography In Patients With Brca1/2-Mutated Breast Cancer Receiving Talazoparib, Lilie L Lin, Franklin Wong, Ruitao Lin, Timothy Yap, Jennifer K Litton

Faculty, Staff and Student Publications

Purpose: We tested the ability of [18F] fluorthanatrace (FTT), a radiolabeled analog of poly(ADP-ribose) polymerase (PARP)-1 inhibitors, to demonstrate target engagement on positron emission tomography (PET) scans from patients with newly diagnosed primary breast cancer receiving the PARP inhibitor (PARPi) talazoparib.

Methods: Seven patients with germline BRCA1/2 pathogenic variants underwent [18F]FTT PET-computed tomography scanning at baseline, and five underwent repeat scanning 14 days after talazoparib initiation. Maximum uptake on PET was quantified in the primary tumor, involved nodes, contralateral pectoralis muscle, and lumbar vertebra body level 3, and compared between the two time points.

Results: Blocking of [18F]FTT was observed …

Mc-Keyboard: A Practical Phase I Trial Design For Targeted Therapies And Immunotherapies Integrating Multiple-Grade Toxicities, Liyun Jiang, Zhulin Yin, Fangrong Yan, Ying Yuan

Faculty, Staff and Student Publications

In targeted therapies and immunotherapies, the occurrence of low-grade (e.g., grade 1-2) toxicities (LGT) is common, while dose-limiting toxicities (DLT) are relatively rare. As a result, conventional phase I trial designs, solely based on DLTs and disregarding milder toxicities, are problematic when evaluating these novel therapies.

Methods: To address this issue, we propose a novel phase I design called a multiple-constraint keyboard (MC-Keyboard) that integrates multiple toxicity constraints, accounting for both DLT and LGT, for precise dose escalation and de-escalation, and identification of the maximum tolerated dose (MTD). As a model-assisted design, an important feature of MC-Keyboard is that its …

A Real-Time Iot-Based Data Acquisition And Monitoring System For Photovoltaic Applications, Adam Barbosa, Hamza Mubarak, Fazel Mohammadi, Mohammad J. Sanjari, Mehrdad Saif

Electrical & Computer Engineering and Computer Science Faculty Publications

The transition to low-carbon energy systems, driven by climate change and fossil fuel scarcity, highlights technologies, such as Photovoltaic (PV) technology, for sustainable energy generation. This paper focuses on enhancing the efficiency of PV monitoring systems by leveraging Internet of Things (IoT) technology for accurate and real-time monitoring of essential parameters, such as voltage, current, and output power. Significant gaps in cost-effective and reliable IoT integration for PV monitoring are addressed, with an emphasis on predictive modeling. In this regard, a low-cost real-time IoT-based data acquisition and monitoring system for PV systems, as a proof of concept for future endeavors …

Assessing The Reproducibility Of Research Based On The Food And Drug Administration Manufacturer And User Facility Device Experience Data, Xinyu Li, Yubo Feng, Yang Gong, You Chen

Faculty, Staff and Student Publications

Objective: This article aims to assess the reproducibility of Manufacturer and User Facility Device Experience (MAUDE) data-driven studies by analyzing the data queries used in their research processes.

Methods: Studies using MAUDE data were sourced from PubMed by searching for "MAUDE" or "Manufacturer and User Facility Device Experience" in titles or abstracts. We manually chose articles with executable queries. The reproducibility of each query was assessed by replicating it in the MAUDE Application Programming Interface. The reproducibility of a query is determined by a reproducibility coefficient that ranges from 0.95 to 1.05. This coefficient is calculated by comparing the number …

Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk For Breast Cancer, Xiaohui Sun, Shiv P Verma, Guochong Jia, Xinjun Wang, Jie Ping, Xingyi Guo, Xiao-Ou Shu, Jianhong Chen, Andriy Derkach, Qiuyin Cai, Xiaolin Liang, Jirong Long, Kenneth Offit, Jung H Oh, Anne S Reiner, Gordon P Watt, Meghan Woods, Yaohua Yang, Christine B Ambrosone, Stefan Ambs, Yu Chen, Patrick Concannon, Montserrat Garcia-Closas, Jian Gu, Christopher A Haiman, Jennifer J Hu, Dezheng Huo, Esther M John, Julia A Knight, Christopher I Li, Charles F Lynch, Lene Mellemkjær, Katherine L Nathanson, Barbara Nemesure, Olufunmilayo I Olopade, Andrew F Olshan, Tuya Pal, Julie R Palmer, Michael F Press, Maureen Sanderson, Dale P Sandler, Melissa A Troester, Wei Zheng, Jonine L Bernstein, Matthew F Buas, Xiang Shu

Faculty, Staff and Student Publications

Breast cancer includes several subtypes with distinct characteristic biological, pathologic, and clinical features. Elucidating subtype-specific genetic etiology could provide insights into the heterogeneity of breast cancer to facilitate the development of improved prevention and treatment approaches. In this study, we conducted pairwise case-case comparisons among five breast cancer subtypes by applying a case-case genome-wide association study (CC-GWAS) approach to summary statistics data of the Breast Cancer Association Consortium. The approach identified 13 statistically significant loci and eight suggestive loci, the majority of which were identified from comparisons between triple-negative breast cancer (TNBC) and luminal A breast cancer. Associations of lead …

A Cell Cycle-Aware Network For Data Integration And Label Transferring Of Single-Cell Rna-Seq And Atac-Seq, Jiajia Liu, Jian Ma, Jianguo Wen, Xiaobo Zhou

Faculty, Staff and Student Publications

In recent years, the integration of single-cell multi-omics data has provided a more comprehensive understanding of cell functions and internal regulatory mechanisms from a non-single omics perspective, but it still suffers many challenges, such as omics-variance, sparsity, cell heterogeneity, and confounding factors. As it is known, the cell cycle is regarded as a confounder when analyzing other factors in single-cell RNA-seq data, but it is not clear how it will work on the integrated single-cell multi-omics data. Here, a cell cycle-aware network (CCAN) is developed to remove cell cycle effects from the integrated single-cell multi-omics data while keeping the cell …

Human Trafficking Screening Tools Amongst Migrants And Refugees: Current Tools And Future Outlooks, Audra Fox

Student Theses

While various human trafficking screening tools exist to help stakeholders identify indicators and risk of trafficking, few tools are designed specifically for use amongst migrants and refugees. Via interviews with anti-trafficking stakeholders, the following qualitative study describes what tools stakeholders currently use to asses trafficking amongst migrants and refugee, and if stakeholders desire a new tool specific for migrant/refugee populations. Thematic results indicate that most stakeholders are not using validated tools for trafficking victims, let alone migrants and refugees (n=5, 38.5%). Of the total sample, 62% of participants (n=8) reported various screening discrepancies across stakeholders. Additionally, …

Razorblade Swing: Sympathy For The Dead, Game Design Document, Matthew Sparksman

Postgraduate

Sydney of the late 20s was a world of dark, crisp shadows and flashing blades. The war has recently ended, and there is a hunger, a mania, to forget and bury the ghosts and spirits. But the dead, and things inhuman, do not like to be forgotten.

Razorblade Swing is a tabletop roleplaying game that seeks to explore this world through the eyes of street-level, everyday, vulnerable people, particularly women. The main conceit is that the Razor Wars were the product of the ghosts and spirits of war. Those who come back often deal with this through addiction, vice and …

The Eternal Flame: Creating Visual Storytelling Through Emotion Design, Rebekka Cottam

Postgraduate

This creative practice research project explores the use of emotion design techniques through visual storytelling in the form of a 68-page graphic novel design and an accompanying exegesis. The research examines emotion theory, exploring how a visual story can comprise of emotion design elements through techniques within shape language, emotive signals, the semiotics of colour, genre, symbolism, and emotive storytelling structures.

Via a creative component, the research documents the practical application of the theoretical concepts using the form of a graphic novel, highlighting the importance of the emotional affect on an audience experience.

Smart Automatic Modal Hammer Predictor–Corrector Approach For Accurate Excitation Of Dynamical Systems, Mohammad Nasr

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

This research introduces an innovative solution that revolutionizes the study of linear and nonlinear dynamical systems—a smart automatic modal hammer. With its affordability and intelligent capabilities, this automatic modal hammer becomes an invaluable tool for research and industry, enabling repeatable strikes with precise force control. This system's significance becomes particularly evident when studying nonlinear systems, which heavily rely on the excitation level for their dynamics. By offering a cost-effective design this proposed system proves to be robust in accelerating research on nonlinear dynamics, providing researchers with an efficient and accessible means to delve deeper into these complex systems. The proposed …

Ultrasonic Nondestructive Quantification Of Case Depth In Railroad Bearing Components, Trevor K. Adelung

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

While in service, railroad bearings must withstand large loads to ensure smooth operation. These large loads can lead to failure due to rolling contact fatigue (RCF), for which small cracks initiate just beneath the surface of the components. As a preventative measure, bearings are manufactured with a hardened surface layer called the effective case depth (ECD). Current methods in industry use destructive hardness testing to quantify the ECD. While accurate, this method is costly and time consuming. Ultrasonic nondestructive testing would provide a more efficient and cost-effective method to determine ECD. In this thesis, diffuse ultrasonic shear backscatter was used …