Digital Commons Network^™

Of Cells And Tissues: Identifying The Elements Of A Diabetic Cardiac In Vitro Study Model, Ivana Hernandez

Open Access Theses & Dissertations

This study aimed to elucidate the impact of advanced glycation end products (AGEs) and glucose shock on cardiomyocyte viability, gene expression, cardiac biomarkers, and cardiac contractility. Firstly, AGEs were generated in-house, and their concentration was confirmed using absorbance measurements. AC16 cardiomyocytes were then exposed to varying doses of AGEs, resulting in dose-dependent decreases in cell viability. The maximum tolerated dose of AGEs was determined, revealing significant downregulation of the cardiac gene gap junction alpha 1 (GJA1). Furthermore, the study assessed the effects of AGEs, glucose shock, and their combination on biomarkers, cardiac myosin heavy chain (MHC), and connexin-43 (Cx-43) in …

Comparative Study Of Hydrogen Embrittlement On Ebm Inconel 718 As-Built And Hiped Specimens, Julio Cesar Diaz

Open Access Theses & Dissertations

This study investigates the effects of hydrogen embrittlement (HE) on Inconel 718 parts produced using Electron Beam Melting (EBM) with a spot melting scanning strategy, focusing on analyzing the material's microstructure and mechanical properties. This research aims to understand the impact of hydrogen charging on both as-built and Hot Isostatically Pressed (HIPed) samples of Inconel 718, a material widely used in high-stress applications in aerospace and energy industries.The methodology included detailed characterization using techniques such as Electron Backscatter Diffraction (EBSD), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM) followed by hydrogen charging of EBM-fabricated Inconel 718 samples. Mechanical testing, …

Staying Fresh: Unconventional Approaches Towards Advancing Energy Sustainability, Water Resources, And Community Resiliency In The Southwestern United States, Judith Hoyt

Open Access Theses & Dissertations

This dissertation addresses critical challenges in urban heat management, sustainable energy resource utilization, and water quality communication through three studies. Study 1 investigates the impact of roof color on urban heat islands in Tucson, Arizona where approximately 70% of roofs display high albedo (i.e., light) colors. Energy consumption simulations conducted indicate that converting dark- to light-colored roofs could save Tucson approximately $1,400,000 annually in energy costs, highlighting the potential of cool roofs for energy savings and improved thermal comfort. Study 2 assesses the sources of lithium in subsurface waters in West Texas and South Central New Mexico. Water chemistry data …

Interpretations Of Aesthetic Experience And Its Enactment In High School Visual Arts Education, Kenneth Albert Dore

Open Access Theses & Dissertations

This dissertation sought to identify interpretations of Aesthetic Experience (AE) of high school visual arts teachers and purposes of its facilitation in their classrooms. Five high school visual arts teachers within a large school district in West Texas were interviewed. A qualitative Hybrid Phenomenological Method was utilized to analyze the data consisting of a descriptive and an interpretive approach. The descriptive approach highlighted common and unique characteristics of aesthetic experience as interpreted by the teachers. An interpretive approach was also employed utilizing Aesthetic Critical Pedagogy, Feminist Theory, and Aesthetic Theory frameworks along with my 20-years-experience as a visual arts teacher. …

Acute Changes In Inflammatory Biomarkers Expression Following Cosmetic Surgery With Use Of Compression Garment, Michael James Sanchez

Open Access Theses & Dissertations

BACKGROUND: Inflammation is an acute phase response to physiological conditions such as infection, tissue injury, and tissue stress and malfunction (Medzhitov, 2008). Inflammation caused by surgical trauma (tissue injury) elicits a myriad of responses by the patient that is experienced far past the operation. It is estimated that American individuals will undergo nine surgeries throughout an 85 year lifespan (Lee & Gawande, 2008). Focus on surgical recovery modalities has grown over the past few decades. The use of compression garments (CG+) following surgery has been shown to be successful in preventing deep vein thrombosis, pulmonary embolisms, as well as aiding …

Neural Networks For Decisions Under Uncertainty, Edwin Tomy George

Open Access Theses & Dissertations

Neural networks are used in many real-world applications, ranging from classification tasks to medical diagnostics. For each task, a neural network is typically able to make predictions due to its ability to extract meaningful patterns from processing large amounts of data. Thus, given the increases in available data in recent decades, the performance of neural networks in making accurate predictions has greatly increased. However, this data often comes with ingrained uncertainties due to measurement errors or the inherent variability of individual data points. Neural networks can learn despite the errors in the overall data, but what if we want them …

Do Investors Value Firm's Application Of Cryptocurrency And Blockchain Technology?, Shensi Wang

Open Access Theses & Dissertations

This paper examines how investors view a firm's involvement with cryptocurrency or blockchain technology, measured by 10-K disclosures containing the related keywords. I find that investors negatively react to the information related to cryptocurrency or blockchain in the three-day window, but the negative trend is reversed after day four. Surprisingly, the topic analysis indicates that the market reacts positively to all topics related to cryptocurrency and blockchain, except for the "competition environment," suggesting that factors outside adopting cryptocurrency or blockchain affect the negative correlations observed before.

Haiga In The Borderland: Sociolinguistic Perception And Variable Production Among Bilinguals In El Paso, Elyana Amparan

Open Access Theses & Dissertations

The linguistic variant haiga in the Ciudad Juárez, Mexico – El Paso, Texas border region is often a stigmatized feature within the bilingual community. This non-standard form, derived from haya (the present subjunctive of haber “to be” in Spanish) carries negative social connotations and is often perceived as incorrect. Our aim was to investigate the use and attitudes towards haiga in the bilingual population at the U. S. – Mexico border. A text infilling task was employed to elicit the use of haiga and an attitude elicitation task using memes was used to investigate the participants attitudes towards the form. …

Experimental And Computational Investigation Of Green Laser Propagation Through Turbulent Medium In A Water Tank, Richard Owusu Adansi

Open Access Theses & Dissertations

Turbulence medium poses significant challenges to the propagation of laser beams, impacting applications such as free-space optical communication, remote sensing, and laser weapons systems. Therefore, comprehending and mitigating turbulence effects are vital for enhancing the performance of these systems. Analysis of a strong turbulence impact on electromagnetic wave propagation requires extensive knowledge of the Earth's atmospheric and Oceanic phenomena and Maxwell's electromagnetic theory of light as a propagating wave of electric and magnetic fields. Optical systems' propagation often encounters Strong Turbulence, causing interference and diffraction. Nonetheless, light propagation through randomly fluctuating media has been an exciting and active area of …

J Mich Dent Assoc August 2024

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association provides news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. It stands as the primary publication reaching Michigan dentists.

In the August 2024 issue, the Journal focuses on the 2024 Mission of Mercy event held in Flint Original content includes:

• A cover story on the MOM

• A feature article on Locum Tenens Dentists

• A New Professional Column

• News You Need, an editorial, and regular department articles covering MDA Foundation activities, MDA Services, Dentistry and the Law, and Staff Matters.

Additional feature article …

Signatures Of Selection, Gene Flow, And Genetic Drift On The Genomes Of A Recent Avian Radiation, Flor Brigitte Hernandez Camacho

Open Access Theses & Dissertations

Speciation is not a discrete event but rather a gradual process that occurs along a continuum. Initially, populations remain genetically and reproductively connected, but they become reproductively isolated as the process of speciation progresses. Advances in DNA sequencing technology has helped our understanding of the processes that contribute to changes in the genetic composition of populations over the progression of speciation, also known as drivers of evolution (i.e. genetic drift, mutation, selection, and gene flow). Among them, hybridization, or the interbreeding between distinct lineages, is increasingly recognized as a natural process that can have significant consequences to the speciation process. …

Thieves Like Us: The Effectiveness Of A Positive Psychology Intervention On Compassion Fatigue, Burnout, And The Loss Of Compassion Satisfaction Among Peer Support Specialists, Eugene Lopez

Open Access Theses & Dissertations

Two common phenomena of helping professions are compassion fatigue (CF), and decreased compassion satisfaction (CS). Literature on CF and decreased CS focuses on professionals with extensive education, training, and higher compensation. Peer Support Specialists (PSS) are helping professionals providing comparable support to clients while in recovery, and may be more susceptible to CF, decreased CS, and a return to substance use. Methods to impact these outcomes, including positive psychology interventions (PPIs), are worth investigating as they are generally inexpensive, can be tailored, and may reduce turnover and absences. The current study used the PPI, Using Signature Strengths in a New …

Robust Multivariate Estimation And Inference With The Minimum Density Power Divergence Estimator, Ebenezer Nkum

Open Access Theses & Dissertations

The estimation of the location vector and scatter matrix plays a crucial role in many multivariate statistical methods. However, the classical likelihood-based estimation is greatly influenced by outliers, potentially leading to unreliable decisions. Hence, a fundamental challenge in multivariate statistics is to develop robust alternatives that can maintain performancein the presence of outliers and deviations from the assumed data distribution. Unfortunately, methods with good global robustness often substantially sacrifice efficiency. To address this, we propose the adoption of Minimum Density Power Divergence (MDPD) estimation, a well-established robust technique known for its efficiency and statistical robustness to outliers and model violations. …

Semantic Linguistic User Profiles For Automatic Computational Narrative Creation For Scientific Models, Angel Uriel Ortega Castillo

Open Access Theses & Dissertations

The outcomes of scientific models can be hard to understand given the need for context, domain knowledge, and many variables and data being used. This research aims to provide users of scientific models with understandable information that can be automatically generated. For the context of this research, understandable is defined as being correctly interpreted (i.e., with respect to the original intent of the data). Scientific information can be conveyed to users in the form of a narrative or visualizations, and these are not necessarily separate from each other, but rather complimentary. One of the objectives of this research is to …

Integrating Machine Learning And Simulation For Resource Planning Of Hospital Systems Based On Predicted Length Of Stay, S M Atikur Rahman

Open Access Theses & Dissertations

Recently Hospital Systems faced a high invasion of patients generated by several events such as health crisis related epidemic (COVID, FLU) or seasonal flows. Hence, managing hospital bed availability and efficiency with proper care is obligatory for addressing the challenges associated with the overburden of patients. However, the Length of stay (LOS) is often increased due to the high patient influx and overcrowding problem occurs within the Hospital. It resolves these issues, it is essential for hospital authority to predict the Patients LOS which is the crucial indicator for the use of medical resources (allocation, utilization of providers and resource) …

Quantum Circuit Optimization Leveraging Multi-Qubit Exchange Interactions In Spin Qubits, Miguel Gonzalo Rodriguez

Open Access Theses & Dissertations

This thesis looks into how multi-qubit exchange interactions can be used to improve quantumcircuits in semiconductor quantum devices. Pairwise interactions between qubits are a common tenet of traditional quantum computing paradigms, although they can impose complexity and depth constraints on circuits. In order to improve the efficiency and scalability of quantum circuits, this research explores the theoretical underpinnings and practical uses of multi-qubit interactions. A thorough theoretical framework is formulated, outlining the mathematical equivalence of a unitary matrix representing interactions between multiple qubits. We obtain the timeevolution operator by analyzing the Hamiltonian of three spin-1/2 particles. A number of quantum …

Seismic Imaging Of Mcmurdo Ice Shelf Near Williams Airfield, Yeshey Seldon

Open Access Theses & Dissertations

Seismic exploration has played a crucial role in understanding the Earth's interior and has been successfully employed in various regions, including Antarctica. This research focuses on analyzing a 1000-m seismic line on McMurdo Ice Shelf near Williams Airfield, as part of the Thwaites Interdisciplinary Margin Evolution (TIME) project. The McMurdo Ice Shelf, covering an expansive area within the Ross Ice Shelf, has undergone significant changes due to evolving oceanic and atmospheric conditions. The presence of Circumpolar Deep Water (CDW) has recently impacted the ice shelf, with warmer ocean waters causing basal melting and changes in wind patterns affecting ice flow …

Ecological, Climatic, And Geomorphic Controls Of The Transport And Fate Of Co2 In Coastal Arctic Aquatic Ecosystems, Alina Spera

Open Access Theses & Dissertations

Due to the ecological and physical responses of arctic tundra to warming, organic carbon (C) stored in frozen permafrost soils is increasingly at risk of mineralization and export to aquatic systems, the coast, and atmosphere. Although many coastal aquatic systems in the Arctic are likely net sources of CO2 to the atmosphere, little is known about the drivers of inorganic C flux and how these systems contribute to regional C budgets. This dissertation addresses several lapses in our understanding of coastal inorganic C dynamics in arctic Alaska via three data chapters. In chapter 2, I examine seasonal and regional variability …

How Supply Chains Respond To Disruptions: Three Essays On Responses To Operational, Geopolitical, And Natural Disaster Disruptions, Travis Kulpa

Graduate Theses and Dissertations

The ability to respond to supply chain disruptions efficiently and effectively is a highly sought after capability, particularly in light of recent events such as the COVID-19 pandemic, geopolitical conflicts, and major natural disasters. These events have led researchers, practitioners, and policymakers to ask: how can we better use our resources to respond to supply chain disruptions? This dissertation examines responses to the three main types of supply chain disruptions: operational disruptions, geopolitical disruptions, and natural disasters. The first study examines how US importers adjust between air and containerized transportation in response to shipment delays and abnormally high demand from …

A Uniformly Most Powerful Test For The Mean Of A Beta Distribution, Richard Ntiamoah Kyei

Electronic Theses and Dissertations

The beta distribution is used in numerous real-world applications, including areas such as manufacturing (quality control) and analyzing patient outcomes in health care. It also plays a key role in statistical theory, including multivariate analysis of variance (MANOVA) and Bayesian statistics. It is a flexible distribution that can account for many different characteristics of real data. To our surprise, there has been very little work or discussion on performing statistical hypothesis testing for the mean when it is reasonable to assume that the population is beta distributed. Many analysts conduct traditional analyses using a t-test or nonparametric approach, try transformations, …

Quantifying Physical Function: Moving Towards A New Definition And Better Assessment, Anthony Campitelli

Graduate Theses and Dissertations

Though poor physical function (PF) and disability are two of the most impactful problems facing older adults today, the field of kinesiology has not yet devised a method of measuring PF, thus limiting investigations with the potential to lead to improved PF interventions and assessments. This dissertation aimed to develop a single, continuous measure of PF using a latent variable modeling approach, and then use the generated scores to evaluate the role of lower body muscular power in PF assessment and to construct an improved PF assessment battery for predicting overall PF. Each aim of this dissertation was addressed through …

Understanding And Control Of Frustration And Topological Defects In Ferroic Matter, Suyash Rijal

Graduate Theses and Dissertations

Ferroic matter are of great importance as they provide a platform to extend the understanding of many-body physics and also for their amazing functional properties relevant for technological advancements. The work in this dissertation is dedicated to two of such ferroic materials.

First is CrGeTe₃ (CGT), a two dimensional (2D) magnet discovered in 2017. The discovery of two-dimensional magnetism has invigorated the research community as their low dimensionality offers a unique avenue to understand and investigate the origin of magnetism in these atomically thin systems and harvest diverse application such as information processing, storage and transfer using their magnetic …

Students' And Teachers' Perceptions Of Play On Students' Classroom Behavior, Melissa Bradt

Graduate Theses and Dissertations

Play is an integral part of human nature. Research has demonstrated that play supports physical, socio-emotional, and cognitive development in children and even adults. However, according to the American Association for the Child’s Right to Play (2024), 40% of school districts in the U.S. have eliminated or reduced recess in order to promote academic excellence as measured by standardized tests. How does the reduction in play time influence students’ classroom behavior? An examination of this question has tremendous theoretical and societal impact as it informs the influence of the environment on human development. This fundamental question in human development has …

L-Arabinose Induced Overexpression For Crystallographic Analysis Of The Spoiie Protein From Clostridioides Difficile, Danielle M. Maynard

Graduate Theses and Dissertations

The SpoIIE protein plays a crucial role in the sporulation process of Clostridioides difficile, a pathogen responsible for severe gastrointestinal diseases. Understanding the structural and functional aspects of SpoIIE is pivotal for deciphering its role in sporulation and exploring its potential as a therapeutic target. This study investigates the impact of varying concentrations of L-arabinose on the overexpression of SpoIIE in C. difficile, aiming to optimize protein yield and purity for subsequent crystallization and structural determination via X-ray crystallography. Using a recombinant expression system in Escherichia coli, different concentrations of L-arabinose were employed to induce SpoIIE overexpression. Protein purification was …

Quantum Modeling & Experimental Studies Of Radical Chemistry, Justin Michael Barrett

Graduate Theses and Dissertations

This work describes two projects centered around radical chemical mechanisms. The first investigation generalized the utility of a C-N bond homolysis followed by a [1,3] – rearrangement synthetic strategy found possible in N-alkylated thiazole & benzothiazole species onto analogous systems. Computational investigation guided the inquiry on structurally analogous systems that would favor a radical, [1,3] – rearrangement. Herein, we describe the implementation of that mechanism to transform Breslow Intermediate-like substrates into tertiary alcohol and amide products under facile conditions. We confer on the proficiency of this strategy with 2-pyridinemethanol and the problematic implementation with 2-(aminomethyl)pyridine. The second investigation solved a …

Impacts Of High-Frequency Operation On Magnetics And Performance On Isolated Power Electronic Converter Design, David Arturo Porras Fernandez

Graduate Theses and Dissertations

The pursuit of high-power density and high switching frequency is a central theme in the advancement of power electronic converters. While these parameters offer significant benefits in terms of compactness and performance, they also introduce challenges related to efficiency and thermal management. This doctoral dissertation aims to provides a design framework to analyze the implications of high-frequency operation (> 100 kHz) on magnetics design and performance in power electronic converters, particularly when integrating silicon carbide (SiC) power modules. It examines the advantages and disadvantages of high-frequency operation and delves into its effects on the performance of the converter, focusing on …

The Riddle Of Religious Language, Luke Hillman

Graduate Theses and Dissertations

The following project analyzes religious life through the lens of religious language. Motivated by ideas of Wittgenstein and Wittgensteinians, religious language is shown to be nonsensical, and yet significant. Wittgenstein connects how we understand language with how we understand life, and this connection extends to religious life. This project offers an answer to how religious language is unique by comparing religious language to riddles and the process of answering riddles. In addition, religious language becomes understandable with imagination, a relationship with the transcendent, and an understanding of the kinds of language present in religious discourse. These ideas are solidified with …

Supply Chains Shocks, Network Linkages, And Economic Outcomes, Romeo Eric Neuyou Nana

Graduate Theses and Dissertations

One prominent consequence of the Covid-19 pandemic was the disruption of critical parts of the global supply chain. In the U.S., delays at ports and shortages of critical inputs such as semiconductors have negative ripple effects across the economy. This situation prompts a surge of interests from academics, business leaders, and policy makers alike. However, the evidence of the quantification of supply chain disruptions’ impact and its drivers on economic variables are still scant. In this essay, I investigate the extent of the impact of supply chain shocks on the U.S. economy and the mechanisms through which they affect economic …

Modeling, Optimization, And Characterization For Choke Horn Antennas, Ibrahim Nasser I Alquaydheb

Graduate Theses and Dissertations

This dissertation presents a comprehensive study focusing on the modeling, optimization, and characterization of choke horn antennas (CHAs). An analytical model designed to capture the parameters of CHA and derive the total radiated fields from the choke and waveguide elements is primarily focused on in this work. Compared to the use of simulation software, such as ANSYS HFSS (High Frequency Structure Simulator) or CST Studio, which employs numerical methods to simulate and calculate antenna performance, numerous advantages are offered by the analytical model. Analytical models provide deeper insight into electromagnetic interactions and the principles governing antenna behavior, leading to a …

Investigating The Applications Of Peps To The Measurement Of The Stabilities Of Staphylococcal Nuclease (Stw) And Human Acidic Fibroblast Growth Factor (Hfgf1), Motolani Omolade Matthew

Graduate Theses and Dissertations

This dissertation presents a detailed investigation into the applications of Protein Equilibrium Population Snapshot H/D Exchange Electrospray Ionization Mass Spectrometry (PEPS-H/D exchange or PEPS) method. This method is based on protein equilibrium unfolding, and its fundamental capability is to capture a "snapshot" of the protein's state, allowing us to monitor the ratio of the unfolded to folded populations at different chemical denaturant concentrations. First, to increase the accuracy of PEPS data analysis for assessing protein stability, the traditional linear extrapolation method (LEM) was replaced. Instead of using LEM, which calculates free energy change based on the peak ratio of unfolded …