Digital Commons Network^™

Pkd1 Mutant Clones Within Cirrhotic Livers Inhibit Steatohepatitis Without Promoting Cancer, Min Zhu, Yunguan Wang, Tianshi Lu, Jason Guo, Lin Li, Meng-Hsiung Hsieh, Purva Gopal, Yi Han, Naoto Fujiwara, Darren P Wallace, Alan S L Yu, Xiangyi Fang, Crystal Ransom, Sara Verschleisser, David Hsiehchen, Yujin Hoshida, Amit G Singal, Adam Yopp, Tao Wang, Hao Zhu

Faculty, Staff and Student Publications

Somatic mutations in non-malignant tissues are selected for because they confer increased clonal fitness. However, it is uncertain whether these clones can benefit organ health. Here, ultra-deep targeted sequencing of 150 liver samples from 30 chronic liver disease patients revealed recurrent somatic mutations. PKD1 mutations were observed in 30% of patients, whereas they were only detected in 1.3% of hepatocellular carcinomas (HCCs). To interrogate tumor suppressor functionality, we perturbed PKD1 in two HCC cell lines and six in vivo models, in some cases showing that PKD1 loss protected against HCC, but in most cases showing no impact. However, Pkd1 haploinsufficiency …

Madelung Mechanics And Superoscillations, Mordecai Waegell

Mathematics, Physics, and Computer Science Faculty Articles and Research

In single-particle Madelung mechanics, the single-particle quantum state Ψ(⃗x, t) = R(⃗x, t)eiS(⃗x,t)/h is interpreted as comprising an entire conserved fluid of classical point particles, with local density R(⃗x, t)2 and local momentum ⃗∇S(⃗x, t) (where R and S are real). The Schrödinger equation gives rise to the continuity equation for the fluid, and the Hamilton–Jacobi equation for particles of the fluid, which includes an additional density-dependent quantum potential energy term Q(⃗x, t) = − ¯h2 2m ⃗∇R(⃗x,t) R(⃗x,t) , which is all that makes the fluid behavior nonclassical. In particular, the quantum potential can become negative and create a …

Stroke Severity, Caregiver Feedback, And Cognition In The Regards-Cares Study, Jason A Blake, D Leann Long, Amy J Knight, Burel R Goodin, Michael Crowe, Suzanne E Judd, J David Rhodes, David L Roth, Olivio J Clay

2020-Current year OA Pubs

BACKGROUND: Cognitive impairment after stroke is common and is present in up to 60% of survivors. Stroke severity, indicated by both volume and location, is the most consequential predictor of cognitive impairment, with severe strokes predicting higher chances of cognitive impairment. The current investigation examines the associations of 2 stroke severity ratings and a caregiver-report of poststroke functioning with longitudinal cognitive outcomes.

METHODS AND RESULTS: One hundred fifty-seven caregivers and stroke survivor dyads participated in the CARES (Caring for Adults Recovering From the Effects of Stroke) project, an ancillary study of the REGARDS (Reasons for Geographic and Racial Differences in …

Balancing Ecology And Practicality To Rank Waterbodies For Preventative Invasive Species Management, Caleb P. Roberts, William E. Grant, Matthew L. Horton, Lindsey A.P. Labrie, Miranda R. Peterson, Jane S. Rogosh, Hsiao-Hsuan Wang

Biological Sciences Faculty Publications and Presentations

• ‘Early detection and rapid response’ (EDRR) is the most successful framework for preventative invasive species management, but prioritizing localized EDRR actions with limited resources is challenging. An approach that ranks individual locations, such as waterbodies, for EDRR by combining an invasive species' establishment risk with the practicality of managing it could help set reasonable priorities.
• Here, we worked with regional practitioners in Arkansas, USA, and the broader Southeastern USA to co-produce a workflow for preventative aquatic invasive species management that (1) estimates establishment risk under current and future climates with a species distribution model, (2) scores waterbodies according to difficulty …

Stories About The David Rowlands Family Of Ellensburg, Washington, Joy Main Smith

Works by Local Authors

Including David's upbringing in Montgomeryshire Wales, his brother Robert's coming to America first, his siblings who stayed in the United Kingdom, and his 32 years with the Northern Pacific Railroad in Ellensburg.

Stress Granule Formation Helps To Mitigate Neurodegeneration, M. Rebecca Glineburg, Evrim Yildirim, Nicolas Gomez, Genesis Rodriguez, Jaclyn Pak, Xingli Li, Christopher Altheim, Jacob Waksmacki, Gerald M. Mcinerney, Sami J. Barmada, Peter K. Todd

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Cellular stress pathways that inhibit translation initiation lead to transient formation of cytoplasmic RNA/protein complexes known as stress granules. Many of the proteins found within stress granules and the dynamics of stress granule formation and dissolution are implicated in neurodegenerative disease. Whether stress granule formation is protective or harmful in neurodegenerative conditions is not known. To address this, we took advantage of the alphavirus protein nsP3, which selectively binds dimers of the central stress granule nucleator protein G3BP and markedly reduces stress granule formation without directly impacting the protein translational inhibitory pathways that trigger stress granule formation. In Drosophila and …

Identification And Characterization Of A Skin Microbiome On Caenorhabditis Elegans Suggests Environmental Microbes Confer Cuticle Protection, Nadia B Haghani, Robert H Lampe, Buck S Samuel, Sreekanth H Chalasani, Molly A Matty

Faculty, Staff and Students Publications

In the wild, C. elegans are emersed in environments teeming with a veritable menagerie of microorganisms. The C. elegans cuticular surface serves as a barrier and first point of contact with their microbial environments. In this study, we identify microbes from C. elegans natural habitats that associate with its cuticle, constituting a simple “skin microbiome.” We rear our animals on a modified CeMbio, mCeMbio, a consortium of ecologically relevant microbes. We first combine standard microbiological methods with an adapted micro skin-swabbing tool to describe the skin-resident bacteria on the C. elegans surface. Furthermore, we conduct 16S rRNA gene sequencing studies …

Garai Mission: Two Microsatellites Embarking Four Imagers For Multispectral Submetric Earth Observation Serving Critical Applications, Jon Paul Babio, Bastiaan Lagaune, Staffan Persson, Enne Hekma, Xavier Lopez

Small Satellite Conference

SATLANTIS MICROSATS SA and OHB Sweden are finalizing 2 micro satellites together under the project name GARAI, first launch scheduled in October 2024. This paper will present the current status of the High-Resolution Multispectral satellite and the services it will enable.

Each satellite will embark two binocular imagers from the iSIM family, iSIM-90 and iSIM-170, combining high resolution images and videos with swath values up to 13 km and multispectrality, with a total of 14 different filters split between the four optical channels covering SWIR spectra, VIS Polarimetry, and PAN + VNIR spectra.

The GARAI mission incorporates OHB Sweden's flight …

Tracers Mission And Gnc Architecture, Sanny Omar, Reid Reynolds

Small Satellite Conference

The Tandem Reconnection and Cusp Electrodynamics Reconnaissance Satellites (TRACERS) NASA mission consists of two identical spinner spacecraft built by Millennium Space Systems to investigate the effects of solar wind on the Earth's magnetosphere, particularly in the Northern "magnetic cusp" region near the magnetic North pole. The TRACERS satellites will measure AC/DC magnetic fields, electric fields, and electron/ion distributions to better characterize Earth-sun interactions and determine whether magnetic reconnection phenomena are primarily spatially or temporarily driven. This will improve our ability to understand and forecast space weather and "solar storms" which have the potential to disrupt or damage power grids and …

Lessons Learnt From N3ss Gnc Operations, Jonathan Serrand, Frederick Viaud

Small Satellite Conference

N3SS is a triple Cubesat launched the 9th of October 2023. This in-orbit demonstrator embeds a miniaturized Software Developed Radio-Frequency payload that measures signals received in L and S bands. CNES, the French space agency, has been developing this satellite with the support of U-Space, a French company provider of next-generation nanosatellites. After about two weeks of commissioning, the spacecraft started its mission, which has been ongoing for six months now.

This article is focusing on the lessons learnt from the design, validation and commissioning of N3SS Guidance, Navigation and Control (GNC) system.

The GNC of N3SS includes attitude and …

Starling Cubesat Swarm Technology Demonstration Flight Results, Scott Miller, Caleb Adams, Nahum Alem, Howard Cannon, Randy Grashuis, Ted Hendriks, Soon Hwang, Michael Iatauro, Craig Pires, Justin Kruger, Simone D'Amico

Small Satellite Conference

The Starling swarm of four 6U CubeSats launched in July 2023 to test four key technologies to enable future swarm missions:

1) Mobile Ad-Hoc Networking (MANET) over a crosslink radio network

2) Autonomous onboard decision-making for operations

3) Optical-based absolute and relative navigation

4) Autonomous maneuver planning and execution

The Starling team implemented the Better Approach to Mobile Ad-hoc Networking (B.A.T.M.A.N.) protocol to automatically manage the crosslink network of four satellites. The B.A.T.M.A.N. protocol uses a decentralized approach to managing a molti-hop mesh network of devices, in this case, a satellite swarm. The four satellites were able to successfully establish …

Operating In A Unique Three Body Orbit With A Stuck Thruster, Hannah Umansky, Jack Kelly, Rebecca Rogers, Ethan Kayser, Alec Forsman, Connor Ott, Anthony Zara, Michael Caudill

Small Satellite Conference

The CAPSTONE mission, currently operating in an Earth-Moon L2 Near Rectilinear Halo Orbit (NRHO), encountered a thruster anomaly in transit to NRHO that resulted in thruster valve remaining permanently open. After resolving the initial anomaly recovering the spacecraft from body rates greater than 120 deg/s, the CAPSTONE team redesigned the thruster controller as well as the spacecraft state machine to enable continued propulsive operations including successful insertion into and sustained operations in NRHO. While the redesign enabled continued utilization of the propulsion system with a stuck thruster, the resulting system presents continued operational challenges within the NRHO environment.

The CAPSTONE …

Noda News April 1996

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

The volume number and issue for this item were mislabeled at the time of publication. It has been moved to the correct location but retains the original misprints.

Noda News March 1996

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

The volume number and issue for this item were mislabeled at the time of publication. It has been moved to the correct location but retains the original misprints.

Noda News February 1996

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

The volume number for this item was mislabeled at the time of publication. It has been moved to the correct volume but retains the original misprint.

Results From On-Orbit Operation Of Cubesat-Scale Robotic Arms On The International Space Station, Khush Thakor, Taiwo Wusu, Christine Maceo, Jin S. Kang

Small Satellite Conference

Technological advancements in robotics and additive manufacturing have accelerated the on-orbit capabilities of space vehicles. These advancements, combined with the surge in satellite constellations and the harsh space environment, motivated innovative approaches for sustaining space assets using other space vehicles, including on-orbit servicing, removal, and manufacturing. On-orbit servicing enables maintenance, repairs, and upgrades to existing satellites, decelerating the accumulation of space debris and offering a cost-effective alternative to traditional satellite replacement. On-orbit removal (relocation or collection) of defunct spacecraft from orbital graveyards declutters space real estate for future space infrastructure and human spaceflight. On-orbit manufacturing reduces launch costs and facilitates …

Noda News January 1996

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

The volume number for this item was mislabeled at the time of publication. It has been moved to the correct volume but retains the original misprint.

Amsat-Oscar-7, A Still Operational, Small-Satellite History Lesson, Jan A. King, Frank Wiesenmeyer, Scott Wiesenmeyer

Small Satellite Conference

It has often been reported that the oldest satellites still working in space are, collectively, the JPL Space Probes Voyager 1 and Voyager 2. The Voyagers were both launched in 1977 to take advantage of the planetary alignment called, back then, the "Grand Tour". This was the alignment of the outer planets, which allowed, using gravitational assist, both Voyagers to visit multiple planets each. Both missions were nothing short of spectacular and they still expand our imaginations. Their images changed the human vision of our solar system. But, are they really the oldest, still functional spacecraft in outer space? What …

Membership Meeting And Closing Ceremonies, The Mythopoeic Society

Mythcon

While the Members’ Meeting portion of Mythcon will be of interest primarily to members of the Mythopoeic Society, all conference participants are welcome to attend. Led by the Mythopoeic Society Stewards, the meeting will announce and discuss timely and necessary Society topics. Following the meeting, we will host our traditional leave-taking closing ceremonies which feature singing songs dear to Mythcon regulars. Words and music at: https://mythsoc.org/mythcon/mythcon-closing-songs.htm Members’ Meeting and Closing Ceremonies take place Monday morning, 11:15 am - 1 pm in the Terrace Rooms.

Discussion Of The Mythopoeic Society Fantasy And Scholarship Award Nominees And Winners, David Lenander

Mythcon

David Lenander, who served on all of the Awards committees, leads a discussion of the finalists this year, hopefully joined by a few of the other committee members

Peer Support For Second Victims In The Healthcare Setting, Levi Gangi

Advances in Clinical Medical Research and Healthcare Delivery

Adverse and traumatic events happen regularly in healthcare settings, and often they create a clinician “second victim” who struggles with feelings of guilt, isolation, doubt, and incompetence. Research has shown that clinicians desire support in the wake of such adverse events, but that factors such as stigma, culture of perfection, and lack of an available structured peer program limit the support that might be offered. Healthcare institutions contract with EAP (employee assistance program) agencies to provide counseling for employees, but it is more likely that a second victim will seek out or welcome help first from a peer who shares …

The Role Of Osteopathic Manipulative Treatment In Neonatal Abstinence Syndrome, Kathryn Workman, Andrea M. Bodine, Md, Victoria Tuttle, Do

Advances in Clinical Medical Research and Healthcare Delivery

Context: The United States opioid epidemic has been an ongoing public health crisis. Nationally, maternal opioid use resulted in 82% increase in Neonatal Abstinence Syndrome (NAS), from 2010 to 2017. The opioid withdrawal process of NAS can lead to somatic dysfunctions. Osteopathic Manipulative Treatment (OMT) may decrease muscular and fascial strain in the body and provide relaxation to the NAS neonate.

Objectives: The objectives of this study were to compare the length of hospital stay (LOS) of NAS neonates who received OMT, and neonates given standard medical care without OMT and to evaluate the change in weight of the two …

A Cross-Disciplinary Undergraduate Research Project: Bonding Through Books With Incarcerated Mothers And Grandmothers, April Terry, Sarah Miller

Criminal Justice Faculty Publications

This study addresses two areas of need in the literature. First, we recognize the impact of experiential-learning on student outcomes and fewer opportunities within the social sciences. Second, as academics in criminal justice and education, we are aware of educational needs of incarcerated persons. The current study blended together experiential-learning alongside a reading program within one state’s women’s correctional facility, targeting (grand)mothers. Two faculty and 40 students, spanning two academic departments, completed a research-based experiential-learning project with one community partner. This undergraduate project sought to benefit students, incarcerated (grand)mothers, and the (grand)children of incarcerated (grand)mothers through a read-aloud program. Through …

Analyzing Hiv/Aids Trends And Disparities In The Bronx: A Comparative Study With Nyc Boroughs, Caleb Adjei

CUNY Mexican Studies Institute

This study analyzes changes in reported HIV/AIDS cases over time in the Bronx, identifying the racial/ethnic groups and neighborhoods most affected by the disease. The Bronx consistently exhibits the highest rate of new HIV diagnoses among New York City’s boroughs, with Latino/Hispanic and Black populations being disproportionately impacted. Key neighborhoods like High Bridge-Morrisania, Crotona-Tremont, and Fordham-Bronx Park have the highest case concentrations. Despite advancements in healthcare and treatments like antiretroviral therapy, disparities persist. The findings highlight the need for targeted interventions to support the most affected communities and address the underlying social determinants contributing to the disparities in HIV/AIDS diagnoses.

Jamal Morton V. Director Virgin Islands Bureau Of Corrections

2024 Decisions

USDC for the District Court of the Virgin Islands

Gnana Chinniah V. East Pennsboro Township

2024 Decisions

USDC for the Middle District of Pennsylvania

Walter Anderson V. Michael Dohman

2024 Decisions

USDC for the Middle District of Pennsylvania

James Moyle V. Brianna Moyle : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from ruling of the Honorable Judge Jennifer Mabey of the Fourth Judicial District in and for Wasatch County as to a Petition for Divorce under U.C.A. § 30-3-1, et. seq.

Brody N. Miles, 15201 Moody Brown Law Attorney for James Moyle

Sarah Jenkins Dewey Bart Johnsen Hannah Ector Parsons Behle & Latimer Attorneys for Brianna Moyle

Effective Data Breach Prevention Strategies In Hospitals, Melissa Nichol Ramos

Walden Dissertations and Doctoral Studies

The healthcare industry has been a rapidly growing target for data breach incidents. Data security is essential to health information managers (HIMs) because of their responsibility to safeguard health data and prevent cyberattacks affecting clinical operations. Grounded in the conceptual framework of the unified information security policy compliance model, the purpose of this qualitative pragmatic inquiry was to explore effective strategies by six HIMs who successfully implemented effective cybersecurity strategies in their organizations. Data were collected from semistructured interviews and public sources of information. Thematic analysis revealed three major themes: (a) differences in HIMs’ approaches to data security; (b) human …

Greenfield Family Trust V. Olive Fountain Land Company Llc Appellant's Brief Dckt. 48538

Idaho Supreme Court Records & Briefs, All

No abstract provided.