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Atypical Hemolytic Uremic Syndrome Following Influenza B: A Case Report, Kathryn E. Mcgraw, Amanda P. Porter, Alyssa M. Moffitt, Marina E M Golden, Heather Stewart Aug 2024

Atypical Hemolytic Uremic Syndrome Following Influenza B: A Case Report, Kathryn E. Mcgraw, Amanda P. Porter, Alyssa M. Moffitt, Marina E M Golden, Heather Stewart

HCA Healthcare Journal of Medicine

Background

Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy that presents with a triad of hemolytic anemia, thrombocytopenia, and acute kidney impairment. It can be attributed to mutations in an array of different complement proteins leading to the overactivation of the complement system, the most impacted being the alternative pathway. Though rare, influenza B has been documented as a potential trigger to the development of aHUS.

Case Presentation

We discuss a 10-year-old girl with a history of aHUS who was found to have a repeat episode of aHUS following an influenza B infection. There have only been a few …


Steroid-Dependent Recurrent Iga Vasculitis In A 19-Year-Old Woman, Hannah Berrett, Shivangi Gohil, Rebecca Kurian, Patricia Neyman Aug 2024

Steroid-Dependent Recurrent Iga Vasculitis In A 19-Year-Old Woman, Hannah Berrett, Shivangi Gohil, Rebecca Kurian, Patricia Neyman

HCA Healthcare Journal of Medicine

Background

Immunoglobulin A (IgA) vasculitis is common in children and typically resolves spontaneously. However, when presenting in adults, it is more likely to be severe and recurrent.

Case Presentation

We present the case of a 19-year-old female patient with recurrent steroid-dependent IgA vasculitis. She had a history of a prolonged episode of IgA vasculitis in childhood. She presented to our hospital with proteinuria and a painful, palpable purpuric rash on her bilateral lower extremities. She was treated with high-dose intravenous steroids. When steroids were tapered, the patient had a recurrence of her painful rash. Over several months, she developed steroid-induced …


Characteristics Of Patients Hospitalized To Community Hospitals With Malignant Brain Tumors And Factors Associated With Discharge Destination, Se Won Lee, Thanapath D. Thantacheva, Denny Mack Aug 2024

Characteristics Of Patients Hospitalized To Community Hospitals With Malignant Brain Tumors And Factors Associated With Discharge Destination, Se Won Lee, Thanapath D. Thantacheva, Denny Mack

HCA Healthcare Journal of Medicine

Background

Our main objective was to compare the characteristics and hospital outcomes of patients with primary and metastatic brain malignancies and to investigate the associated factors related to hospital outcomes.

Methods

We conducted a retrospective, cross-sectional study of 1628 patients with brain malignancies from 8 community hospitals between 2017 and 2022 who were identified using International Classification of Disease codes. A stepwise logistic regression was used to identify demographics and clinical characteristics associated with in-hospital mortality and home discharge.

Results

The median age was 65 years old, with 72.5% of patients having metastatic brain malignancies. After 7.2 days of hospital …


A Clinical Review On Spinal Epidural Abscess: Epidemiology, Pathophysiology, Diagnosis, And Management For Emergency Medicine And Hospitalist Physicians, Madeline A. Guy, Jeffrey S. Guy Aug 2024

A Clinical Review On Spinal Epidural Abscess: Epidemiology, Pathophysiology, Diagnosis, And Management For Emergency Medicine And Hospitalist Physicians, Madeline A. Guy, Jeffrey S. Guy

HCA Healthcare Journal of Medicine

Spinal epidural abscess (SEA), a critical surgical emergency, demands prompt recognition and intervention to prevent severe complications and fatalities. The incidence of SEA is notably increasing, particularly among individuals with diabetes, intravenous drug use, or a history of invasive spinal procedures. Although SEA can manifest through various clinical symptoms, the presence of its classic triad—back pain, fever, and neurological deficits—is noteworthy despite its occurrence in only 10% to 13% of cases. Identifying this triad is vital due to its high specificity for SEA, which is essential to guiding swift diagnostic and therapeutic actions in a condition where early intervention is …


Methodologies For Dry Fixation And Taxidermy Of Education-Oriented Scorpion Specimens, Victoria Tang Aug 2024

Methodologies For Dry Fixation And Taxidermy Of Education-Oriented Scorpion Specimens, Victoria Tang

Euscorpius

Scorpions hold a renowned status as iconic creatures across numerous cultures in the world. Traditionally preserved as desiccated specimens for educational purposes, they have been exhibited in museums and pedagogic collections, serving as concrete epistemological conduits for public education on biodiversity. However, these specimens frequently lack meticulous organization, potentially misrepresenting the animals’ ethological characteristics. This brief article aims to offer paradigmatic guidance for taxidermy of scorpions, ensuring a more accurate depiction of their in vivo habitus, achievable through the use of readily obtainable tools and undemanding techniques.


The Scarlet – Volume Ciii, No. 1 (August 30, 2024), Scarlet Staff Aug 2024

The Scarlet – Volume Ciii, No. 1 (August 30, 2024), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The August 30, 2024 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.


Attracting Foreign Direct Investment (Fdi) In Madani Economy: What Factors Matter?, Yi-Shan Chong, Chee-Lip Tee Aug 2024

Attracting Foreign Direct Investment (Fdi) In Madani Economy: What Factors Matter?, Yi-Shan Chong, Chee-Lip Tee

International Journal of Management, Finance and Accounting

Foreign Direct Investment (FDI) has long been acknowledged as a vital driver of economic development, and Southeast Asia stands out as a prime destination for such investments. However, Malaysia's share of FDI in the region has been diminishing, signalling a loss of competitiveness. In response, the Malaysian government has prioritized enhancing competitive strength in its recent development framework, Madani Economy. This study aims to shed light on the factors that require greater attention to achieve these objectives. Utilizing the Autoregressive Distributed Lag (ARDL) approach and monthly data spanning from 2010 to 2019, the findings underscore the importance of growing market …


Analysis Of Isotopic Effects On Hydrogen Oxidation, Jacob Carter Wilde Aug 2024

Analysis Of Isotopic Effects On Hydrogen Oxidation, Jacob Carter Wilde

Theses and Dissertations

Tritium generation presents a significant hazard during operation of nuclear reactors and necessitates safety precautions in the case of a combustion incident. Accurate kinetic models should inform these safety precautions, however, reliable tritium data do not exist to generate such models. This work focuses on laminar flame speed, which is an important component of kinetic models. Current estimates based on established kinetic theories and experimental measurements of the other isotopes of hydrogen predict tritium to have a flame speed approximately 70% that of standard protium over a broad range of stoichiometries at one atmosphere in air. These estimates are based …


Geology Of Sinai Tholus, Thaumasia Plateau, Mars, Haley Mosher Aug 2024

Geology Of Sinai Tholus, Thaumasia Plateau, Mars, Haley Mosher

Theses and Dissertations

A new geologic map of the Sinai Tholus region on the Thaumasia plateau, Mars reveals the structural, magmatic, and stratigraphic complexity that can be found in the Tharsis region on Mars, and may help answer key questions about the origin of the subvolcanic basement, evolution of the regional stress field, development of Valles Marineris, and magmatic history of the region. Sinai Tholus is a topographic high in a relatively flat, lava flow covered part of Thaumasia Plateau, just south of the central part of Valles Marineris. Here, five stratigraphic units and one generalized impact unit have been mapped at a …


The Minutes Of The Marshall University Graduate Council Meeting, August 30, 2024, Marshall University Graduate Council Aug 2024

The Minutes Of The Marshall University Graduate Council Meeting, August 30, 2024, Marshall University Graduate Council

Graduate Council Minutes

No abstract provided.


Barriers And Facilitators To Administering Burn Pit Registry Exams In Vha Facilities, Patricia V Chen, Israel C Christie, Kyler M Godwin, Jaehwan Han, Nisha Jani, Anays Sotolongo, Asma Ali, Drew A Helmer Aug 2024

Barriers And Facilitators To Administering Burn Pit Registry Exams In Vha Facilities, Patricia V Chen, Israel C Christie, Kyler M Godwin, Jaehwan Han, Nisha Jani, Anays Sotolongo, Asma Ali, Drew A Helmer

Faculty and Staff Publications

Introduction: The Veterans Health Administration (VHA) established the Airborne Hazards and Open Burn Pit Registry (AHOBPR) in 2014 to address exposure concerns for veterans who have served in military operations in Southwest Asia and Afghanistan. By 2021, over 236,086 veterans completed the online questionnaire and 60% requested an AHOBPR examination. Of those requesting an exam, only 12% had an exam recorded in their medical record. This article summarizes barriers and facilitators to delivering AHOBPR exams and shares lessons learned from facilities who have successfully implemented burn pit exams for veterans.

Materials and methods: We (I.C.C and J.H.) constructed a key …


Tommy Coleman V. System One Holdings Llc Aug 2024

Tommy Coleman V. System One Holdings Llc

2024 Decisions

USDC for the Western District of Pennsylvania


Postpartum Depression Screening In The Neonatal Intensive Care Unit At A Tertiary Pediatric Hospital, Abbie Bates Aug 2024

Postpartum Depression Screening In The Neonatal Intensive Care Unit At A Tertiary Pediatric Hospital, Abbie Bates

Doctor of Nursing Practice Final Manuscripts

POSTPARTUM DEPRESSION SCREENING IN THE NEONATAL INTENSIVE CARE UNIT AT A TERTIARY PEDICTRIC HOSPITAL

By

Abbie Kim Bates

Razel Bacuetes Milo, PH.D. DNP., FNP-C

Background: Postpartum depression (PPD) is a treatable mood disorder with an onset at 1-3 months after childbirth. In the United States, PPD occurs at a rate of 1 in 8 women and as high as 1 in 5 women in parts of the country. In unique populations such as the neonatal intensive care unit (NICU), PPD rates can be as high as 40%. The treatment rate for PPD is 50% with a sizable percentage of …


Organ-Specific Dosimetry Following Radiopharmaceutical Therapy For Metastatic Prostate Cancer, Frank J. Arturi, Nilanjan Haldar, Shray Jain, Gia Nguyen, Jessie Dinome, Firas Mourtada, Lydia J. Wilson, Phd Aug 2024

Organ-Specific Dosimetry Following Radiopharmaceutical Therapy For Metastatic Prostate Cancer, Frank J. Arturi, Nilanjan Haldar, Shray Jain, Gia Nguyen, Jessie Dinome, Firas Mourtada, Lydia J. Wilson, Phd

Department of Radiation Oncology Posters

Introduction

  • Radiopharmaceutical Therapy (RPT) uses radioactive agents to target cancer at the cellular level
  • Lu-177 targeting prostate-specific membrane antigen (PSMA), known as 177Lu- PSMA-617, can be used to treat metastatic, castration-resistant prostate cancer (mCRPC)
  • 177Lu-PSMA-617 treatments use a standard dose and treatment regimen for all patients
  • Patients exhibit different side effects and tumor response during treatment


Generation And Curation Of A Reference Sequence Database For Groundwater Organisms, Ashlyn Wandstrat Aug 2024

Generation And Curation Of A Reference Sequence Database For Groundwater Organisms, Ashlyn Wandstrat

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.


A Study On The Impact Of Financial Incentives And Work Environment On Employee Motivation To Work: A Case Study Of Employees Of Paradise Estate Management Company, Okoye Shedrach Obumneme, Farha Ghapar Aug 2024

A Study On The Impact Of Financial Incentives And Work Environment On Employee Motivation To Work: A Case Study Of Employees Of Paradise Estate Management Company, Okoye Shedrach Obumneme, Farha Ghapar

International Journal of Management, Finance and Accounting

The study aims to investigate the impact of financial incentives and workplace environment on employee work motivation. Individually, the study examines the impact of work allowances, employee wages, organisational culture, and internal communication on employee motivation to work in an organisation. The research employed a survey research design. The population of the study focused on the employees of Paradise Estate Management Company. A total of 79 respondents were selected from a pool of 120 employees in the organisation. The questionnaires were administered and distributed to respondents through Google Form. Multiple regression analysis was adopted to test the different hypotheses. The …


The Role Of Indonesian Doctors As Content Creators In Fighting Health Hoaxes, Myths, And Stigma On Social Media, Lydia Okva Anjelia, Deddy Mulyana, Jenny Ratna Suminar Aug 2024

The Role Of Indonesian Doctors As Content Creators In Fighting Health Hoaxes, Myths, And Stigma On Social Media, Lydia Okva Anjelia, Deddy Mulyana, Jenny Ratna Suminar

JURNAL KOMUNIKASI INDONESIA

Amidst the proliferation of disinformation and misinformation related to health on social media, the public must ensure that the sources of information are trustworthy. This research aims to explain the role of doctors in the fight against health hoaxes, myths, and stigma spread through social media. The study adopts qualitative research with a phenomenological approach to understand doctors' experiences and perceptions regarding their efforts to address health hoaxes, myths, and stigma on social media. Fifteen doctors as content creators in Jakarta and Bandung were selected as informants using purposive sampling. The data was collected through interviews, observation participation, and documentation …


Development Of Transportation Training Modules For Adults With Disabilities To Support Community Mobility, Victoria Ann Owens Aug 2024

Development Of Transportation Training Modules For Adults With Disabilities To Support Community Mobility, Victoria Ann Owens

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Background: A person with Autism spectrum disorder (ASD) or Intellectual disability (ID) may encounter internal barriers to public transportation modes including executive functioning. These may include challenges in initiation, planning, topographical orientation, waiting, and selecting correct embarkment transfers trains and buses. Additionally, the whole person journey is negatively impacted by sensory overload from light, sounds, crowded spaces, and impaired regulation strategies.

Purpose: The purpose of this quality improvement project is to mitigate these challenges of internal barriers inhibiting transit needs within this population by developing and dispersing a transportation education video tool. These efforts aim to promote optimal transportation engagement …


Minutes For Graduate Curriculum Committee Meeting, August 30, 2024, University Of Northern Iowa. Graduate Curriculum Committee. Aug 2024

Minutes For Graduate Curriculum Committee Meeting, August 30, 2024, University Of Northern Iowa. Graduate Curriculum Committee.

Minutes - Graduate Curriculum Committee

Minutes of the committee that oversees the development of the curriculum of the University of Northern Iowa Graduate Studies.


Flight Preparations And Data Reduction For The Third Flight Of The Cosmic Infrared Background Experiment-2, Kazuma Noda Aug 2024

Flight Preparations And Data Reduction For The Third Flight Of The Cosmic Infrared Background Experiment-2, Kazuma Noda

Theses

The extragalactic background light (EBL) at infrared (IR) wavelengths contains information about the stars that lived during the epoch of reionization, which was the first era of star formation that occurred a few hundred of Myr after the Big Bang. Anisotropy measurements of the IR EBL by CIBER-1, Spitzer, and AKARI have shown that the amplitude of its surface brightness fluctuations exceeds what is expected from known galaxy populations. Potential sources of this excess include stars during the epoch of reionization, intra-halo light (IHL) from low-mass stars stripped from their parent galaxies, and the decay products of dark matter candidate …


Inflation–Inequality Puzzle: Is It Still Apparent?, Edmond Berisha, Rangan Gupta, Orkideh Gharehgozli Aug 2024

Inflation–Inequality Puzzle: Is It Still Apparent?, Edmond Berisha, Rangan Gupta, Orkideh Gharehgozli

Department of Economics Faculty Scholarship and Creative Works

Purpose: The primary focus of this study is to examine the distributional consequences of the widespread increase in prices. The fundamental question the study aims to address is whether the dynamics of income distribution due to higher inflation differ in the short term compared to the long run. Design/methodology/approach: The authors estimated a panel-data model (fixed effects) using inequality and inflation data available at a high frequency, i.e. on a quarterly basis for over 30 years, and found evidence that inflation causes rapid swings in income distribution. Findings: The authors’ contribution to the literature lies in providing evidence that inflation …


Shared And Distinct Cortical Morphometric Alterations In Five Neuropsychiatric Symptoms Of Parkinson’S Disease, Qianling Lu, Zhuang Zhu, Heng Zhang, Caiting Gan, Aidi Shan, Mengxi Gao, Huimin Sun, Xingyue Cao, Yongsheng Yuan, Joseph I Tracy, Qirui Zhang, Kezhong Zhang Aug 2024

Shared And Distinct Cortical Morphometric Alterations In Five Neuropsychiatric Symptoms Of Parkinson’S Disease, Qianling Lu, Zhuang Zhu, Heng Zhang, Caiting Gan, Aidi Shan, Mengxi Gao, Huimin Sun, Xingyue Cao, Yongsheng Yuan, Joseph I Tracy, Qirui Zhang, Kezhong Zhang

Farber Institute for Neuroscience Faculty Papers

Neuropsychiatric symptoms (including anxiety, depression, apathy, impulse–compulsive behaviors and hallucinations) are among the most common non-motor features of Parkinson’s disease. Whether these symptoms should be considered as a direct consequence of the pathophysiologic mechanisms of Parkinson’s disease is controversial. Morphometric similarity network analysis and epicenter mapping approach were performed on T1-weighted images of 505 patients with Parkinson’s disease and 167 age- and sex-matched healthy participants from Parkinson’s Progression Markers Initiative database to reveal the commonalities and specificities of distinct neuropsychiatric symptoms. Abnormal cortical co-alteration pattern in patients with neuropsychiatric symptoms was in somatomotor, vision and frontoparietal regions, with epicenters in …


Thermomechanical Analysis Of Biomass Plastic Composite (Bpc), Solomon Chijioke Madu, Victor Sunday Aigbodion, Ikechukwu Ike-Eze Aug 2024

Thermomechanical Analysis Of Biomass Plastic Composite (Bpc), Solomon Chijioke Madu, Victor Sunday Aigbodion, Ikechukwu Ike-Eze

Makara Journal of Technology

High-performance electrical insulation material can be manufactured using biomass plastic composite (BPC), which is a new type of composite material that is either made up of one or a combination of natural plant fibers/particulates, such as bamboo, cellulose fiber, rice husks, or hemp, and thermoplastic granules. In this study, the BPC composite material that was developed comprised polyethylene (PE), rice husk, and oyster shell. The results of the study showed a significant optimal improvement in the morphological, thermodynamic, and mechanical properties during the addition of 20% to 30% biomass particulates (i.e., rice husk and oyster shell). The thermogravimetric analysis, storage …


Endwall Contouring For Lowering The Thermal Load And Augmenting The Turbine Efficiency, Arjun Kozhikkatil Sunil, Tide Porathoor Sunny Aug 2024

Endwall Contouring For Lowering The Thermal Load And Augmenting The Turbine Efficiency, Arjun Kozhikkatil Sunil, Tide Porathoor Sunny

Makara Journal of Technology

Endwall contouring having significance in delineating ideal endwalls competent in thermal load depletion is the focus of this study. We have successfully utilized non-axisymmetric contoured endwalls to enhance turbine performance by controlling the secondary flow characteristics in a blade passage through steady-state numerical hydrodynamics. The supreme endwall pattern could lower the gross pressure loss at the design stage and is related to the size of the top-loss location being productively lowered. The selective numerical shape change using multi-objective optimization at the most prominent locations resulted in contoured endwall geometry and a considerable reduction of thermal exchange in the vane passage …


Inevitable Or Preventable? A Pilot Intervention To Reduce Burnout Risk In Acute Care Nurses, Emily R. Kelly Aug 2024

Inevitable Or Preventable? A Pilot Intervention To Reduce Burnout Risk In Acute Care Nurses, Emily R. Kelly

Clinical Psychology Dissertations

Purpose: Burnout among healthcare workers is widespread and costly, resulting in calls for action to reduce the experience and impact of this work-related phenomenon. Burnout among nurses has been associated with impaired patient safety, decreased quality of care, lower levels of patient satisfaction, decreased productivity, and higher levels of intent-to-leave the profession. Aim: The aims of this study are to assess whether sleep problems mediate the relationship between recovery and burnout and to examine the feasibility of a pilot intervention to enhance recovery, improve sleep quality, and reduce burnout among inpatient nurses. Method: Eligible participants included registered nurses who worked …


Factors Influencing Non-Performing Loans Between Islamic And Conventional Banks In Malaysia, Najwa Hanisah Mohd Azmi, Sharifah Fairuz Syed Mohamad, Shahrina Ismail Aug 2024

Factors Influencing Non-Performing Loans Between Islamic And Conventional Banks In Malaysia, Najwa Hanisah Mohd Azmi, Sharifah Fairuz Syed Mohamad, Shahrina Ismail

International Journal of Management, Finance and Accounting

This study reveals the long-term effects of several variables on Non-Performing Loans (NPLs) in Islamic banks (IBs) and conventional banks (CBs) in Malaysia. Using the Autoregressive Distributed Lag (ARDL) technique, the study supports a proactive approach and finds a persistent association between NPLs and asset quality, loan quality, unemployment rate, and inflation rate. Using the ARDL approach, the analysis covers the monthly period from 2018 to early 2021. This study aims to investigate NPLs at two different times: before and after the COVID-19 epidemic. The findings indicate that The ARDL model identifies Loan Quality 1 and 2 as significant influencers …


The Mediating Effect Of Job Satisfaction Between Organizational Learning And Job Performance, Alaa S. Jameel Aug 2024

The Mediating Effect Of Job Satisfaction Between Organizational Learning And Job Performance, Alaa S. Jameel

International Journal of Management, Finance and Accounting

This study aims to find the impact of organizational learning on job performance among preparatory school teachers through the mediator role of job satisfaction. A survey was conducted at six preparatory schools in Heet City, Iraq. The study employed stratified random sampling to ensure a fair representation of samples from all six schools, and a questionnaire was used to collect the data. The results from 183 valid questionnaires were analyzed using Smart-PLS, indicating that organizational learning positively and significantly impacted a teacher’s performance. Moreover, job satisfaction also showed a significant positive effect on job performance. Additionally, organizational learning has a …


Convertible Bond Pricing In Chinese Transportation Industry : A Comparison Methods Between Binomial Tree Model And Black-Scholes Model, Zirui Peng, Xinrui Xinrui, Chui Zi Ong Aug 2024

Convertible Bond Pricing In Chinese Transportation Industry : A Comparison Methods Between Binomial Tree Model And Black-Scholes Model, Zirui Peng, Xinrui Xinrui, Chui Zi Ong

International Journal of Management, Finance and Accounting

One bond type that can lower financing costs for the issuer is a convertible bond. Additionally, its characteristic with option value gives investors access to high-yielding, low-drawdown, and superior investment instruments. Exactly, convertible bonds have a strong market appeal to investors. In recent years, the issuance scale of convertible bonds has continued to expand, and its share in the bond market has gradually increased. Fair pricing is essential to maintaining the convertible bond market’s smooth operation. In light of this, the convertible bonds in the transportation sector listed on the Shanghai Stock Exchange are chosen for this article. Following the …


Micronuclear Collapse From Oxidative Damage, Melody Di Bona, Yanyang Chen, Albert S Agustinus, Alice Mazzagatti, Mercedes A Duran, Matthew Deyell, Daniel Bronder, James Hickling, Christy Hong, Lorenzo Scipioni, Giulia Tedeschi, Sara Martin, Jun Li, Aušrinė Ruzgaitė, Nadeem Riaz, Parin Shah, Edridge K D'Souza, D Zack Brodtman, Simone Sidoli, Bill Diplas, Manisha Jalan, Nancy Y Lee, Alban Ordureau, Benjamin Izar, Ashley M Laughney, Simon Powell, Enrico Gratton, Stefano Santaguida, John Maciejowski, Peter Ly, Thomas M Jeitner, Samuel F Bakhoum Aug 2024

Micronuclear Collapse From Oxidative Damage, Melody Di Bona, Yanyang Chen, Albert S Agustinus, Alice Mazzagatti, Mercedes A Duran, Matthew Deyell, Daniel Bronder, James Hickling, Christy Hong, Lorenzo Scipioni, Giulia Tedeschi, Sara Martin, Jun Li, Aušrinė Ruzgaitė, Nadeem Riaz, Parin Shah, Edridge K D'Souza, D Zack Brodtman, Simone Sidoli, Bill Diplas, Manisha Jalan, Nancy Y Lee, Alban Ordureau, Benjamin Izar, Ashley M Laughney, Simon Powell, Enrico Gratton, Stefano Santaguida, John Maciejowski, Peter Ly, Thomas M Jeitner, Samuel F Bakhoum

Faculty, Staff and Student Publications

Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture catalyzes chromosomal rearrangements, epigenetic abnormalities, and inflammation, yet mechanisms safeguarding micronuclear integrity are poorly understood. In this study, we found that mitochondria-derived reactive oxygen species (ROS) disrupt micronuclei by promoting a noncanonical function of charged multivesicular body protein 7 (CHMP7), a scaffolding protein for the membrane repair complex known as endosomal sorting complex required for transport III (ESCRT-III). ROS retained CHMP7 in micronuclei while disrupting its interaction with other ESCRT-III components. ROS-induced cysteine oxidation stimulated CHMP7 oligomerization and …


Effect Of Tibial Malrotation On Anterior And Posterior Cruciate Ligaments In Bicruciate-Retaining Total Knee Arthroplasty, Muhammad Saakeereen Sa’Audi, Abdul Halim Abdullah, Solehuddin Shuib, Muhammad Azim Mat Raffei, Mohd Fairudz Mohd Miswan, Mohd Afzan Mohd Anuar Aug 2024

Effect Of Tibial Malrotation On Anterior And Posterior Cruciate Ligaments In Bicruciate-Retaining Total Knee Arthroplasty, Muhammad Saakeereen Sa’Audi, Abdul Halim Abdullah, Solehuddin Shuib, Muhammad Azim Mat Raffei, Mohd Fairudz Mohd Miswan, Mohd Afzan Mohd Anuar

Makara Journal of Technology

Osteoarthritis (OA) is a musculoskeletal disorder specified as a joint disease that affects mostly human joints worldwide. Total knee arthroplasty (TKA) is performed to restore the affected joint and relieve the symptoms. However, tibial malrotation, which is one of the most common errors in TKA, results in poor function of the implant and pain after the procedure. People with OA often experience limited mobility and cannot accomplish daily tasks. Finite element analysis (FEA) has been widely applied to interpret the biomechanical and kinematic force along the joint and investigate the cruciate ligament’s mechanical behavior. Unfortunately, one of the problems in …