Digital Commons Network^™

Using Perusall To Increase Student Engagement With Assigned Readings, Diana Moore

Open Educational Resources

This assignment uses collaborative annotation through Perusall to encourage students to complete course readings and engage more actively with assigned texts. Advance discussion questions and peer annotations help students identify key ideas, develop critical reading skills, and improve their ability to summarize and synthesize information. By grading annotations for completion rather than length, the assignment promotes authentic student voices, supports the development of effective reading habits, and reduces reliance on AI-generated responses.

Teaching Peace Where Borders Divide: Interdisciplinary Praxis In A Criminal Justice Program, Lucas Espinoza

Criminal Justice Faculty Publications

This article describes a criminal justice senior-level undergraduate course, CRIJ 4350: Peace, Nonviolence, & Justice, at a Hispanic-serving institution known as the University of Texas Rio Grande Valley, in the U.S.-Mexico borderlands. The course centers five key frameworks: critical pedagogy, intersectionality, decolonial theory, restorative and transformative justice, and trauma-informed care, as this course departs from carceral models of justice education. Grounded in theory, literature, and research from criminal justice, criminology, peace and conflict studies, sociology, political science, ethics/philosophy, social justice, human rights, and critical pedagogy, the course centers student reflection from course evaluations, relationships, and experiences of a faculty member. …

“From Remembering To Shaping”: Narrating Shared Experiences By Co-Designing Cultural Heritage Artifacts In Collaborative Vr, Yushang Yang, Fanxu Meng, Fiona Fui-Hoon Nah, L. C. Ray

Research Collection School Of Computing and Information Systems

The ways people remember and recall places reveal an invisible aspect of cultural heritage (CH), reflecting how individuals and communities relate to these places. Heritage is communal, emerging through collaboratively constructed narratives rather than individual records. To probe how people may share collective memories, we designed an immersive two-person workflow for collaboratively co-designing 3D artifacts and environments in virtual heritage locations, using Generative AI (GenAI) to instantiate these intangible memories. Observations of the co-creation process revealed that participants merged prompts and model placements when negotiating different perspectives. They used spatial operations to compose scenes, and also to express personal and …

“Megadeal” Subsidies, Local Spillovers And Corporate Innovation, Yoojin Lee, Shaphan Ng, Aruhn Venkat

Research Collection School Of Accountancy

We examine whether the largest place-based, firm-specific corporate subsidies (“Megadeals”) awarded by state and local governments affect local firms’ innovation. First, we document that 1) subsidy firms innovate in the subsidized county and 2) subsidy firms bring inventors from other counties into the subsidized county, consistent with subsidy firms generating new knowledge locally. In our main test, we use a stacked cohort design with stringent fixed effects to document that local firms increase patenting following a Megadeal. Cross-sectionally, effects are increasing 1) in subsidy firm innovativeness, 2) in the technological closeness of subsidy firms and local firms, 3) when subsidy …

Beta2-Agonist And Anti-Inflammatory Combination Therapy For Asthma Rescue: A Paradigm Shift In Asthma Care, Neil Skolnik, Jessica Stieritz, Julie Akers, Timothy Hudd, Wendy L. Wright, Ileen Gilbert, Nazrin Yusufova, Bill Cook, Emily Robb, Henry Naddaf

Abington Jefferson Health Papers

The Global Initiative for Asthma (GINA) report and national and international guidelines have shifted away from short-acting beta2-agonist (SABA)-only bronchodilators as first-line asthma rescue therapy, recognizing that both bronchoconstriction and inflammation underlie the increase in symptoms preceding an exacerbation. Instead, the GINA Committee supports strategies to reduce inflammation, such as anti-inflammatory reliever (AIR) therapy (as-needed, low-dose inhaled corticosteroid [ICS]–formoterol or SABA–ICS for symptom relief) and single maintenance and reliever therapy (SMART) or maintenance and reliever therapy (MART; i.e., ICS–formoterol used as both maintenance and as-needed rescue therapy). This narrative review discusses the rationale behind the move toward AIR and SMART …

Polygenic Risk Scores And Hla Class Ii Variants Are Biomarkers Of Corticosteroid Response In Childhood Nephrotic Syndrome., Tiffany Tu, Alejandro Ochoa, Amika Sood, Ashley Dabrik, Megan Chryst-Stangl, Brandon Lane, Guanghong Wu, Frank Donovan, Ursula Harper, Settara Chandrasekharappa, Christopher Esezobor, Adaobi Solarin, David Hooper, Christine Sethna, Sandra Amaral, Mahmoud Kallash, Michelle Rheault, Priya Verghese, Vikas Dharnidharka, Eloise Salmon, Patricia Weng, Tarak Srivastava, Michael E Seifert, Cozumel Pruette, David Selewski, Keisha Gibson, Tracy Hunley, Asiri Abeyagunawardena, Shenal Thalgahagoda, Arvind Bagga, Aditi Sinha, Nicholas Webb, Larry Greenbaum, Ali Gharavi, Krzysztof Kiryluk, Matthias Kretzler, Lisa Guay-Woodford, Simone Sanna-Cherchi, Agnieszka Bierzynska, Ania Koziell, Gavin Welsh, Moin Saleem, Charles Rotimi, Eileen Chambers, Cliburn Chan, Curegn Consortium, Pnrc Glomerular Disease Group, Cibmtr/Nmdp Consortium, Annette Jackson, Adebowale Adeyemo, Rasheed Gbadegesin

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Nephrotic syndrome (NS), a common glomerular disease in children, is classified based on response to corticosteroid therapy as either steroid-sensitive nephrotic syndrome (SSNS), or steroid-resistant nephrotic syndrome (SRNS). However, there are no current reliable predictors of therapy response at initial clinical presentation.

METHODS: To evaluate predictors, we conducted genome-wide association studies, developed polygenic risk scores (PRS) for therapy response and analyzed classical HLA alleles in 1,997 children (994 discovery and 1,003 replication/validation cohorts) previously unstudied children with NS and 3,558 ancestry-matched control individuals.

RESULTS: A significant association with HLA loci defined by variants in HLA-DQB1, HLA-DRB1, and HLA-DQA1 were …

Early Neurodevelopmental Outcomes In Children With Congenital Heart Disease., Mike Seed, Dawn Ilardi, Valerie Rofeberg, Cynthia Ortinau, Caren Goldberg, Garrett Reichle, Lauren Bush, Justin Elhoff, Amy Jo Lisanti, Jennifer Butcher, Caitlin Rollins, Andrew Van Bergen, Shabnam Peyvandi, Emily Bucholz, Stephanie Cox, Lyla Hampton, Jacqueline Sanz, Sonia Monteiro, Shruti Tewar, Kiona Allen, Caroline Lee, Kristi Glotzbach, Nneka Alexander, Laurel Bear, Corinne Anton, Renee Sananes, Linh Ly, Gina Boucher, Kelly Wolfe, Lindsay Edwards, Elizabeth J. Willen, Alexander Tan, Christina Ortega, Erica Sood, Anjali Sadhwani, Kari Crawford Plant, Lauren Quigley, Jessica Pliego, Elizabeth Valles, Abbey Hines, David Wypij, Thomas Miller

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Neurodevelopmental impairments are common in children with congenital heart disease.

OBJECTIVES: To compare neurodevelopmental outcomes by cardiac diagnosis and identify associations between medical and social factors and early neurodevelopmental outcomes among children with congenital heart disease.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional analysis used neurodevelopmental follow-up data obtained between May 1, 2019, and June 30, 2022, and entered into the Cardiac Neurodevelopmental Outcome Collaborative (CNOC) registry, with linkage to the Pediatric Cardiac Critical Care Consortium registry. Children younger than 30 months from 25 CNOC sites were studied. Data analysis was performed between January 2023 and December 2024.

EXPOSURES: Patients …

Severe Thiopurine-Induced Myelosuppression In A Pediatric Acute Lymphoblastic Leukemia Patient With The Nudt15 *1/*6 Genotype: A Brief Report., Jillian Fry, Erin C. Boone, Wendy Y. Wang, Shobana John, Lisa A. Lansdon, Midhat S. Farooqi, Byunggil Yoo, Andrea Gaedigk, Keith August, Terrie Flatt, Laura Ramsey

Manuscripts, Articles, Book Chapters and Other Papers

Variants in TPMT and NUDT15 genes that affect thiopurine metabolism can guide personalized dosing to minimize toxicity. Decreased or no appreciable NUDT15 activity demonstrates impaired breakdown of active thiopurine metabolites which can lead to severe adverse events including potentially life-threatening myelosuppression. Recently, the NUDT15*6 allele was re-classified from having uncertain function to no function by the Clinical Pharmacogenetics Implementation Consortium. Here, we present a pediatric patient with a NUDT15*1/*6 genotype who experienced significant thiopurine-induced myelosuppression. The patient is a 4-year-old female with standard risk-average precursor B-cell acute lymphoblastic leukemia treated per AALL1731. Exome sequencing determined TPMT*1/*1 (normal metabolizer) and NUDT15*1/*6 …

The Effect Of Bai1 Deficiency On Cell Survival During The Critical Period Of Retinal Development, Nicholas Mirmanesh

PCOM Biomedical Studies Student Scholarship

The postnatal retina undergoes further development during the critical period, during which excess neurons are culled, and synapses are refined to shape the mature retinal circuitry. Brain-specific angiogenesis inhibitor-1 (BAI1) has been implicated in synaptic development, phagocytosis, the regulation of angiogenesis, and inflammatory signaling, suggesting it may play an important role in retinal maturation. The goal of this project was to determine how BAI1 deficiency affects retinal cell survival and layer morphology during the critical period. Mice were divided into three genotype groups: BAI1 +/+ Wild Type (WT), +/- (Het), and -/- (KO). Apoptotic cells were quantified using TUNEL staining …

Human-Ai Teaming Under Fire: Lessons From Ukraine’S Human-In-The-Loop Combat Ai Systems, Rahul Kumar Tiwari, Ram Babu

Journal of Strategic Security

This article examines human-artificial intelligence (AI) teaming in Ukrainian combat operations from 2022 to 2025, exploring the integration of AI systems with human decision-making in military contexts and how crisis-driven innovation can lead to human-AI teaming. The research addresses three questions: the effectiveness of human-AI teams compared with human-only or fully autonomous systems; the effect of organizational structures on the sustainability of AI integration; and strategic implications for the development of the doctrine and international security governance in the case of the North Atlantic Treaty Organization (NATO). The methodology uses mixed-method comparative case study analysis of three different Ukrainian systems: …

Disclosure Duties And Responsibilities, Gregory Klass

Georgetown Law Faculty Publications and Other Works

Contract disclosure rules differ in structure, function, and design. Though scholars often treat all these rules under the rubric of duty, in fact they fall into two broad categories. Disclosure duties treat the failure to disclose as a legal wrong; disclosure responsibilities attach positive legal consequences to disclosure but do not treat nondisclosure as a legal wrong. Disclosure duties can be further divided. Specified disclosure duties, which typically apply to consumer and other mass-market transactions, provide detailed guidance regarding both what information to disclose and how to disclose it. Generic disclosure duties, such as the tort of nondisclosure, provide broad …

Table Tennis Training Instrument (Ping Pongers), Derick Alvarado, Peter Sandberg, Andrew Wong

Mechanical Engineering Senior Theses

Table Tennis is an extremely popular sport worldwide, boasting an extensive market. However, it is a sport that generally requires other people to both play and practice with. The goal of this project was to create a machine that would serve table tennis balls for the purpose of individual practice. The machine was meant to fill the niche that other machines of the same type filled by allowing individuals to practice on their own without the assistance of another player or a coach. The main goal of the project was to offer a market competitive device, sharing the same basic …

Camless Valve Engine, Berkeley Burbank, James Thomas Daniel, Haydn Fischer, Nicos Katigbak, John Holden Kleiner, Martin Raabe

Mechanical Engineering Senior Theses

This project focuses on the design and validation of a camless engine valve system as an  alternative to traditional camshaft-based valvetrain architectures. Conventional engines rely on  fixed camshaft profiles that limit performance and efficiency across varying operating  conditions. The goal of this work is to replace both the camshaft and throttle body with a  pneumatically actuated system capable of independently controlling valve timing, lift, and  duration in real time. By removing the mechanical constraints of a camshaft, the system has the  potential to optimize engine operation across all RPM ranges, improving efficiency and overall  performance without requiring major changes to …

Mantaray Profiler, Ashika Balamurugan, Divya Bengali, Angelina C. Ekdawy, Gabriela Ruiz, Alexander Israel Torres, Alondra Valencia Prado, Ysidro Magana

Interdisciplinary Design Senior Theses

Ocean health monitoring is essential for understanding and protecting marine ecosystems, yet existing methods of collecting oceanographic data are often expensive, labor-intensive, and difficult to scale. This project presents the design, integration, and testing of the MANTARAY Profiler, a low-cost, autonomous ocean-monitoring system developed to support repeatable environmental data-collection missions with reduced operator involvement. The system was designed to navigate among multiple surface waypoints, execute vertical profiling maneuvers, and collect water-column data while maintaining a compact, user-friendly, and transportable platform.

The profiler travels horizontally across the water surface to a predetermined GPS waypoint using autonomous navigation and heading-control algorithms. Once …

Mapping The Tar Vrna Interaction With Hiv-1 Integrase, Jian Sun, Rahul Yadav, Tolga Catmakas, Luke Fisher, Nicholas C. Fitzkee, Jacques J. Kessl

Faculty Publications

A series of critical interactions within the viral core between viral RNA (vRNA) and HIV-1 Integrase (IN) has previously been reported. In these studies, contact points between vRNA and IN were identified using RNA-seq and MS-based protein foot-printing approaches. Several IN amino acids located in its C-terminal domain (CTD) were found to be essential for vRNA binding, and their alanine substitution severely impacted the correct morphogenesis of the mature viral core. Here, we have used the TAR element to extend these studies by performing a comprehensive mapping of the interaction by deploying RNA crosslinking and NMR methodologies. Together, these approaches …

Missed Clinic Appointments For Human Papillomavirus-Related Oropharyngeal Cancer, John M. Vieth, Anthony A. Mangino, Melina J. Windon, Joseph Valentino

Biostatistics Faculty Publications

Background: Missing appointments delay treatment affecting patient outcomes and healthcare resource utilization. Adherence to scheduled appointments has not been studied in patients with HPV-related oropharyngeal squamous cell carcinoma (HPV-OPSCC). Methods: We collected data from 36,690,000 scheduled medical outpatient encounters at the University of Kentucky Health Care from 2012 to 2021. A total of 36,579 of these encounters were from 334 patients with HPV-OPSCC. We performed regression analysis of no-show appointments by demographics, tumor characteristics, and insurance factors. Results: The no-shows rate for appointments was significantly higher for the HPV-OPSCC cohort (4.6% vs. 2.2% p < 0.001). The HPV-OPSCC cohort missed 36% of their appointments. Black, Hispanic, younger, those who have ever smoked and patients with advanced tumor stage all had statistically significantly higher no-show rates (p < 0.01). Conclusions: Treatment delay impacts cancer treatment efficacy and no-show appointments burden medical systems. Further research into targeted interventions is needed to lower barriers for attending appointments.

Hospital Bed Tray Table, Ava Mikeska, Sara Chamness, Samantha Kenney, Kaitlyn Ould

Mechanical Engineering

This project documents the design and development of a collapsible hospital bed tray table created through the Mechanical Engineering Senior Project program at Cal Poly, San Luis Obispo. The goal of the project was to reduce the floor space occupied by existing overbed tray tables while preserving the functionality, stability, and durability expected by patients, visitors, and healthcare staff.

The final design modifies a commercially available overbed tray table by incorporating a folding tabletop hinge mechanism and a telescoping base. The hinge allows the tabletop to lock in both the upright and stowed positions, while the telescoping base retracts to …

Thermosiphon Lab Experiment, Ella C. Perry, Zach Barry, Madison K. Felton, Lane A. Hunter

Mechanical Engineering

The Cal Poly Mechanical Engineering Department aims to develop a new lab centered on a thermosiphon solar system. This lab will introduce the operating principles of thermosiphons while integrating concepts from heat transfer, fluid dynamics, and thermodynamics. A thermosiphon functions by heating water using thermal energy. The lab will examine the efficiency of this energy transfer. The final lab will be tailored to enhance student learning while ensuring ease of use for the Mechanical Engineering Department.

Sdsu Extension Calving Camp, Taylor Grussing

Animal Science Research Report 2026

No abstract provided.

Semi-Automated Wine Barrel Filler, Elliot Jason Dejong, Carlo Caesare Deianni, Brady Emerson J. Leib

Mechanical Engineering

The proposed project is a semi-automated wine barrel filler. Currently, there is no streamlined and affordable method for smaller wineries to fill wine barrels without dedicating complete focus to the task. The primary use is controlled filling for white wine fermentation, during which an air gap must be left in the barrel to allow for expansion of the wine during fermentation. Tom Greenough, Saucelito Canyon’s head winemaker, and associate winemaker Bodie Ringhofer are the primary stakeholders in our project and want to consistently fill barrels at their winery to a fluid volume of approximately 50 gallons each. This project serves …

Smart Sleeve, Evan Abalos, Bright Jung, Owen Bowling, Wyatt Eberhart

Mechanical Engineering

Quantifying human arm muscle activity is essential for understanding human movements and helping individuals who suffer from motor or neurological impairments such as stroke or traumatic brain injuries. Today, these individuals, as well as clinicians, researchers, and athletes, face many challenges when using the traditional surface electromyography (sEMG) systems to monitor muscle activities, including complex setup, restricted mobility, discomfort, inconsistent placement of electrodes, and lack of accuracy. Therefore, a comfortable EMG sleeve device that accurately measures arm movement without interfering with daily tasks is needed, which the team will be designing, manufacturing, and testing as their senior project. In addition, …

Me Department Bespoke Coffee Cabinet, Mickie Clyne, Stephen Tamacheepjaroen, Samuel Johnson, Willem Gray

Mechanical Engineering

This senior project involved the design, fabrication, and testing of a custom coffee cabinet for the California Polytechnic State University Mechanical Engineering Department. The project addressed challenges associated with appliance organization, storage efficiency, accessibility, and maintenance within the department’s shared breakroom space. A human-centered design process was used to identify stakeholder needs and develop engineering specifications for the final product.

The completed cabinet integrates custom woodworking, steel pipe frame construction, dedicated K-Cup storage, organized appliance placement, and a rack-and-pinion sliding platform that improves access to the Keurig coffee maker for refilling and maintenance. Design decisions were informed through stakeholder feedback, …

Process Improvement For Thermal Barrier Coating Masking Applications, Katherine Meezan, Aiden Senn, Saksham Giri, Katelyn Perez

Mechanical Engineering

Solar Turbines, a gas turbine manufacturer, needs a more efficient method to prevent the application of a thermal barrier coating (TBC) to select areas of their combustion liners during manufacturing. Currently, the process is labor, material, and time intensive: reusable masking tools should increase the efficiency of the TBC process.

This project is sponsored in full by Solar Turbines, and is under the guidance and administration of three Solar Turbines engineers: Chris Noone, Rick Rogers, and Carson Roff. The project is mentored by Cal Poly senior design Coach, Rick Lasko. This project will be completed by a team of four …

Me3328 Combined Loading Beam Bending Lab, Alejandro Islas, Viswesh Vancheeswaran, Owen Spencer, Henry Andrews

Mechanical Engineering

Serving as a new laboratory experiment for ME 3328 (Design for Strength & Stiffness), strain gauges were adhered, wired, and calibrated on a cantilever beam lab apparatus capable of undergoing pure bending, pure torsion, and combined bending.

Transit Infrastructure And Neighborhood Change: The Impact Of The Q Train Expansion On Commercial Space Use In New York City's Upper East Side, Lily E. Levick

Quantitative Social Science Undergraduate Senior Theses

This paper examines the impact of the 2017 Second Avenue Subway expansion on commercial land uses on New York City’s Upper East Side. The research leverages quantitative models alongside qualitative personal experiences and literature to understand the relationship between infrastructure, space, and neighborhood change from a nuanced perspective. The results show that the studied area experienced a broad trend of de-commercialization between 2003 and 2025, and a simultaneous shift toward commercial zoning in areas closest to new subway stations. These findings encourage us to consider how mobility access is an important driver for change within neighborhoods and urban space, and …

Design And Evaluation Of An Open-Source Ac/Dc Power Converter For Microgrid Applications, Ryan J. Rayos

Master's Theses

This thesis presents the design, implementation, and evaluation of an open-source bidirectional power conversion platform intended for microgrid applications. As distributed energy resources, battery storage systems, and hybrid AC/DC architectures continue to increase in adoption, there is a growing demand for flexible, low-cost, and programmable power electronic platforms capable of interfacing between DC and AC subsystems. Existing commercial solutions are often proprietary and expensive, limiting their accessibility for educational, research, and rapid prototyping applications. This work expands upon the existing open-source Atinverter platform by increasing its operating voltage capability, integrating bidirectional power flow, and implementing telemetry systems suitable for microgrid …

Integration Of Robotic Arm And Conveyor With Programmable Logic Controller, Drake A. Small

Master's Theses

To meet new curriculum demands brought on by Cal Poly's upcoming switch to semesters, a new, cross-disciplinary lab module was developed for EE 435 (Industrial Power Control and Automation). The module emphasizes career-applicable skills, preparing students for the field of controls engineering within the manufacturing industry. These skills include robotic control, computer networking and configuration, and embedded systems. The work focused on integrating a collaborative robot arm to pick-and-place boxes on a conveyor. A myCobot 320 Pi and an Ultimation Powered Roller MDR Conveyor were integrated with the existing PLC system using Modbus RTU and EtherNet/IP communication protocols, respectively. A …

Equitable Decompositions: A Gateway To Spectral Theory Through Graph Automorphisms, Daniel Ford

Master's Theses

Graphs with symmetry appear throughout mathematics and its applications, from the structure of molecules and network design to combinatorial game theory. A central question in spectral graph theory is how to compute or characterise the eigenvalues of the matrices associated with such graphs. Classical decomposition methods, such as diagonalisation or Jordan normal form, accomplish this but only once some spectral information is already known. A different approach, introduced by Barrett et al. (2015), uses the automorphisms of a graph to block-diagonalise its adjacency matrix without any prior spectral information. Because one of the resulting summands is always the quotient matrix …

Effects Of Atmospheric Drag On Angles-Only Initial Relative Orbit Determination Accuracy In Low Earth Orbit, Sydney Walsh

Master's Theses

Growing congestion in low Earth orbit is increasing the demand for effective space situational awareness, straining ground station capabilities. Space-based relative orbit determination offers an alternative, using line-of-sight angle measurements from a chaser spacecraft to estimate a target spacecraft's orbit. This research focuses on angles-only initial relative orbit determination (IROD), where no prior target state knowledge is assumed. It investigates how IROD solution accuracy is affected by differential atmospheric drag between the chaser and target spacecraft. A nonlinear batch least squares filter is designed to estimate the target's initial state, which is compared against a truth solution. It was found …

Determining K Clusters In K-Means Clustering With The Crab Algorithm, Jasmine Kristine S. Cabrera

Master's Theses

Unsupervised clustering often faces the challenge of determining the correct number of clusters in the absence of a true target variable. Traditional methods such as the Elbow Method and the Silhouette Score can produce ambiguous results and rely on assumptions about cluster shape or separation. To address this, we created the Clustering Rivals and Buddies (CRAB) algorithm which evaluates clusters based on stability across multiple subsamples. CRAB uses pairwise classifications to identify points that consistently group together called “Buddies” and points that remain separated called “Rivals.” Applied with K-means, CRAB accurately recovers underlying cluster structures in both spherical and non-spherical …