Digital Commons Network^™

What Do Cancer Genetic Providers Want Us To Know About Variant Reclassification And Recontact That We Are Not Asking? A Thematic Analysis Of Open-Ended Survey Responses, Kerri Brown, Marisel Ponton, Elenita Davidson, Banu Arun, Robert J Volk, Sanjay Shete, Susan K Peterson, Sukh Makhnoon

Faculty, Staff and Student Publications

BACKGROUND: Accurate variant classification and relaying reclassified results to patients is critical for hereditary cancer care delivery. Over a 5- to 10-year period, 6%-15% of variants undergo reclassification. As the frequency of reclassifications increases, the issue of whether, how, when, and which providers should recontact patients becomes important but remains contentious.

METHODS: The authors used inductive thematic analysis to analyze open-ended comments offered by oncologists and genetic counselors (GCs) from a large national survey.

RESULTS: Of the 634 oncologists and cancer GCs, 126 (20%) offered substantive free-text comments. Four thematic areas emerged: 1) ambiguity over professional responsibility to recontact, 2) …

The Effect Of Interruptions In Surgical Counts, Jaidin Degraw, Brooke Gisel

Nursing Research and EBP Day 2024

Retained surgical items can lead to patient frustration and prolonged hospital stays. They remain the top reason for reoperation despite the tools that are used to maintain accurate counts. Minimizing disruptions and distractions in the operating room may be one way to assist circulating nurses in obtaining correct and consistent counts.

Navigating The Paradox Between Professional Challenges And Teacher Well-Being: The Role Of Strategies Within The Resilience Process, Isabelle Krummenacher, Tina Hascher, Caroline Mansfield, Susan Beltman, Julia Mori, Irene Guidon

Research outputs 2022 to 2026

Teaching is an immensely complex profession that often requires managing multiple and varied professional challenges. Despite these challenges, teachers tend to report moderate to high levels of well-being. This qualitative study explored this paradox by investigating the professional challenges reported and the coping strategies Swiss teachers use to support their well-being. Relational problem-solving was identified as a commonly used strategy when professional challenges occur. The unique contribution of this study lies in its further elucidation of the complex relationship between teachers’ professional challenges and well-being embedded in a resilience process. The results of this study provide implications for understanding how …

Re: Comment Letter For Bpsou Draft Phase I Design Investigation Evaluation Report (Dated September 25, 2024), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Ultra-Relativistic Electron Flux Enhancement Under Persistent High Speed Solar Wind Stream, L R. Alves, L A. Da Silva, V Deggeroni, J P. Marchezi, P R. Jauer, G B D Silva, D G. Sibeck

Faculty Publications

The physical mechanisms usually applied to explain the relativistic electron enhancement have been delved into to elucidate non-adiabatic electron acceleration resulting in the ultra-relativistic electron population observed in the outer radiation belt. We considered multisatellite observations of the solar wind parameters, magnetospheric waves, and particle flux to report an unusual local acceleration of ultra-relativistic electrons under a prolonged high-speed solar wind stream (HSS). A corotating interaction region reaches the Earth’s bowshock on August 3, 2016, causing a minor geomagnetic storm. Following this, the magnetosphere was driven for 72 h by a long-term HSS propagating at 600 km/s. During this period, …

Lung Tissue Multilayer Network Analysis Uncovers The Molecular Heterogeneity Of Chronic Obstructive Pulmonary Disease, Nuria Olvera, Jon Sánchez-Valle, Iker Núñez-Carpintero, Joselyn Rojas-Quintero, Guillaume Noell, Sandra Casas-Recasens, Alen Faiz, Philip Hansbro, Angela Guirao, Rosalba Lepore, Davide Cirillo, Alvar Agustí, Francesca Polverino, Alfonso Valencia, Rosa Faner

Faculty, Staff and Students Publications

Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition. Objectives: We hypothesized that the unbiased integration of different COPD lung omics using a novel multilayer approach might unravel mechanisms associated with clinical characteristics.

Methods: We profiled mRNA, microRNA and methylome in lung tissue samples from 135 former smokers with COPD. For each omic (layer), we built a patient network on the basis of molecular similarity. The three networks were used to build a multilayer network, and optimization of multiplex modularity was used to identify patient communities across the three distinct layers. Uncovered communities were related to clinical features.

Measurements …

Factors That Influence Colostrum Yield: Dry Period Length, Peter S. Erickson

UNH Cooperative Extension

No abstract provided.

Re: Comment Letter For Draft Clark Tailings Consolidated Waste Management Area (Ctcwma) Site Investigation Draft Data Summary Report 2019-2023 (Dated October 3, 2024), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Evaluating The Effectiveness Of Edge Line Sinusoidal Rumble Strips On Lane Departure Crash Prevention And Injury Severity, Shubhankar Chintamani Shindgikar

USF Tampa Graduate Theses and Dissertations

Lane departure crashes are one of the most prevalent accidents in Florida and the United States. Various forms of rumble strips have been employed to mitigate and decrease these incidents. The Florida Department of Transportation (FDOT) recently adopted a new sinusoidal rumble strip pattern for statewide implementation of audible and vibratory treatment (AVT). Recent research indicates sinusoidal rumble strips are highly effective in alerting drivers audibly and through tactile vibrations, thus aiding lane departure prevention. Moreover, they generate less external noise compared to other rumble strip textures.

However, a systematic assessment of the safety effectiveness of sinusoidal rumble strips in …

Spatiotemporal Dynamics Of Coastal Nekton Metacommunities In The Western Atlantic, Jonathan A. Peake

USF Tampa Graduate Theses and Dissertations

The processes of diversification, selection, dispersal, and stochastic drift can combine in many ways to assemble ecological communities. A key focus in ecology is to describe and quantify the relative influences of these processes for different systems and explain the mechanisms by which these processes produce patterns of community structure. To accomplish this goal, ecologists have developed several frameworks that seek to integrate processes that occur locally andregionally. The metacommunity concept treats local communities as pieces of a broader landscape that are connected through dispersal of their constituent organisms. Empirical studies have generally lagged behind the development of metacommunity theory. …

Comment Letter For Bpsou Draft Phase I Design Investigation Evaluation Report (Dated September 25, 2024), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Chevron Deference Is Dead, Long Live Deference, Jack M. Beermann

Faculty Scholarship

The demise of Chevron deference standing alone may turn out to be much less important for the future of administrative law and agency regulation than many believe. The Court explicitly approved of deference under the Skidmore factors, which instruct reviewing courts to “resort for guidance, even on legal questions” to “the interpretations and opinions of the relevant agency, made in pursuance of official duty and based upon specialized experience.”8 Further, the Court had already created numerous limitations to the reach of Chevron deference and, as the Court noted, it had not deferred under Chevron in nearly a decade. Chevron deference …

Multi-Sided Information Asymmetry In A Single Contract: Why Revocable Living Trusts Go To Court, James P. Wells

USF Tampa Graduate Theses and Dissertations

Revocable living trust documents (trusts) are among the most important documents created in contemporary estate planning. One of the trust’s objectives is to provide clear guidance to the trustees on how to carry out the grantor's intent. When a trust is contested in court, the objective of the trust has clearly failed. Consequently, understanding why trusts go to court and developing approaches that reduce or eliminate the number of trusts in our courts is an endeavor worthy of research and the primary objective of this research effort.

Ideally, with a clearly stated grantor’s intent and clearly executed interpretation of the …

Alternatively Spliced Map4 Isoforms Have Key Roles In Maintaining Microtubule Organization And Skeletal Muscle Function, Lathan Lucas, Larissa Nitschke, Brandon Nguyen, James A Loehr, George G Rodney, Thomas A Cooper

Faculty, Staff and Students Publications

Skeletal muscle cells (myofibers) are elongated non-mitotic, multinucleated syncytia that have adapted a microtubule lattice. Microtubule-associated proteins (MAPs) play roles in regulating microtubule architecture. The most abundant MAP in skeletal muscle is MAP4. MAP4 consists of a ubiquitous MAP4 isoform (uMAP4), expressed in most tissues, and a striated-muscle-specific alternatively spliced isoform (mMAP4) that includes a 3,180-nucleotide exon (exon 8). To determine the role of mMAP4 in skeletal muscle, we generated mice that lack mMAP4 and express only uMAP4 due to genomic deletion of exon 8. We demonstrate that loss of mMAP4 leads to disorganized microtubule architecture and intrinsic loss of …

Radiological And Elemental Composition Of Cryoconite And Glacier Mice From Vatnajökull, Iceland, Emma Smith, Caroline Clason, Geoff Millward, Alex Taylor, Ralph Fyfe

School of Geography, Earth and Environmental Sciences

Cryoconite has been demonstrated to be an efficient accumulator of some classes of contaminants on glaciers in both mountain and polar environments, however the accumulation of contaminants in cryoconite in Iceland has received very little attention to date. To understand the spatial variability of natural and anthropogenic fallout radionuclides and metals on glaciers in Iceland, we present the first study of this region including both cryoconite from three glaciers: Virkisjökull; Skaftafellsjökull; and Falljökull, together with moss balls (‘glacier mice’) from Falljökull. The cryoconite samples and glacier mice were analysed using XRF spectrometry to assess their elemental composition and gamma spectrometry …

How Wildfires Threaten Water Resources: A Case Study Following The Largest Wildfire Recorded In New Mexico, Eric A. Joseph

Civil Engineering ETDs

Wildfire disturbance propagation along fluvial networks remains poorly understood. We use incident, atmospheric, and water-quality data from the largest wildfire in New Mexico’s history to quantify how this gigafire affected surface runoff processes and mobilized wildfire disturbances into fluvial networks after burning 1382 km². Surface runoff post-fire increased compared to pre-fire conditions, and precipitation events that are frequently observed in the affected watershed (<2-year recurrence) and fell during the post-fire first rainy season resulted in uncorrelated, less frequently observed runoff events (10-year recurrence). Wavelet coherence analysis highlighted that water quality disturbances propagated variably along the network, even at sites located >160 km downstream of the burn perimeter. Our findings emphasize the need to incorporate spatially resolved longitudinal sampling designs into wildfire water quality research and highlight the spatiotemporal co-dependency among atmospheric, terrestrial, aquatic processes …

Moderating Effect Of Urban/Rural Status, State Of Residence, And Health Risk Factors On Maternal Mortality Among Different Races, Emmanuel Agubata

Walden Dissertations and Doctoral Studies

Maternal mortality in the United States is significantly higher than in most developed nations and has been increasing since 2000. Persistent between-group disparities among White, Black, and Hispanic women occur in terms of maternal mortality; however, the reason for this is largely unknown. Using the intersectionality theory, this quantitative study examined if racial groups predicted maternal mortality and to what extent relationships were moderated by geographic area and health risk factors. This nonexperimental correlational historical research design addressed three research questions. The Healthcare Cost and Utilization Project dataset was used for the analysis. The minimum sample size was 988 cases, …

Understanding Teachers’ Perceptions Of Best Practices For English Language Learners, Joshua Daniel Davis

Walden Dissertations and Doctoral Studies

In a district where only 5% of ELLs were deemed language proficient, the problem was the need to understand teacher perceptions of best practices to increase English language learner (ELL) achievement in reading and writing. The purpose of this qualitative study was to examine teacher perceptions of best practices to support ELLs in improving their reading and writing in a heterogeneous high school classroom in a Mid-Atlantic school district. The framework that supported this study was the Cummins model on learners’ language use because it guides teaching and assessing students’ vocabulary acquisition in various contexts. The two research questions probed …

Administrators’ Perception Of Successful Implementation Of Read To Succeed In Title I Schools, Angela Sandifer Flowers

Walden Dissertations and Doctoral Studies

South Carolina implemented its Read to Succeed (RTS) policy in 2014 in accordance with federal requirements. The problem addressed in this study was that there are many students in South Carolina Title I schools still failing to achieve reading proficiency after 3 years of full implementation of RTS. The purpose of this qualitative study was to explore the perceptions of administrators from successful Title I elementary schools on their roles in the change process needed for implementing RTS. The conceptual framework was Fullan’s change theory. For this basic qualitative design, data were collected from semistructured interviews with seven participants who …

Administrators’ Perception Of Successful Implementation Of Read To Succeed In Title I Schools, Angela Sandifer Flowers

Walden Dissertations and Doctoral Studies

South Carolina implemented its Read to Succeed (RTS) policy in 2014 in accordance with federal requirements. The problem addressed in this study was that there are many students in South Carolina Title I schools still failing to achieve reading proficiency after 3 years of full implementation of RTS. The purpose of this qualitative study was to explore the perceptions of administrators from successful Title I elementary schools on their roles in the change process needed for implementing RTS. The conceptual framework was Fullan’s change theory. For this basic qualitative design, data were collected from semistructured interviews with seven participants who …

Realist Assessment Of Fidelity During The Implementation Of The Partners Collaborative Care Intervention For People With Diagnoses Of Severe Mental Illness Within A Cluster Randomised Controlled Trial, Charley Hobson-Merrett, Julia Frost, Ruth Gwernan-Jones, Vanessa Pinfold, Michael Clark, Shamiaa El Naggar,, Linda Gask, Bliss Gibbons, John Gibson, Siobhan Theresa Reilly, Debra Richards, Angela Saunders, Debs Smith, Richard Byng

Peninsula Medical School

Many with severe mental illnesses are underserved by disjointed service provision. PARTNERS aims to address this via collaborative care with recovery-based coaching. PARTNERS was evaluated in a randomised controlled trial. Understanding how intervention delivery compared to the model, why this was, and under what circumstances, aids interpretation of trial results and optimisation of future implementation. This paper reports the results of a Realist assessment of fidelity, exploring delivery compared to model and refining programme theory. Practitioners, service users, supervisors, primary care representatives, and researchers (n = 39) were interviewed. Additional data included session recordings, follow up interviews, practitioner reflective logs, …

Subscriber Selection For New Service Rollout Based On Call Detail Records, Mahendra M. Periyadanam

Defensive Publications Series

This disclosure describes techniques that make use of artificial intelligence (AI) and machine learning (ML) to intelligently select subscribers for new service rollouts based on call detail record (CDR) analysis. CDR data, obtained with user permission, is analyzed to select subscribers who frequently or infrequently use an existing service, enabling prioritizing such subscribers to rollouts of new services. The prioritized subscriber list is provided to a provisioning system to deliver configuration updates over-the-air (OTA) (or via any other mechanism, such as over the internet) to subscriber devices. Feedback from subscriber devices regarding adoption of new features is incorporated enabling refinement …

Correction Notice To: The Effect Of Nigella Sativa Oil On The Prevention Of Phlebitis Induced By Chemotherapy: A Clinical Trial, Niaz Behnamfar, Zohreh Parsa Yekta, Faraz Mojab, Seyyed Mohammad Kazem Naeini

BioMedicine

No abstract provided.

A Combined Nasolabial And Infra-Nasal Bi-Lobe Flap Design With Double Transposition For Reconstruction Of The Ipsilateral Upper And Lower Lips Associated With The Commissure Defect, Nyimi Bushabu Fidele, Yifang Zhao, Wu Tianfu, Yanfang Sun, Bing Liu

BioMedicine

Several classical flap variations have been designed to reconstruct lip and commissure defects. Although most of these variations maybe the best option for repairing defects, there is an increasing risk of anatomic distortion and functional disability, mostly in older persons. Herein, we present a combined nasolabial and infra-nasal bi-lobe flap design with double transposition, which was used to concomitantly close the upper and lower lips associated with commissure defects.

Epigenetic Profiling Of Mutyh, Klf6, Wnt1 And Klf4 Genes In Carcinogenesis And Tumorigenesis Of Colorectal Cancer, Kosar Babaei, Roya Khaksar, Tahereh Zeinali, Hossein Hemmati, Ahmadreza Bandegi, Pirouz Samidoust, Mohammad Taghi Ashoobi, Hooman Hashemian, Kourosh Delpasand, Fereshteh Talebinasab, Hoora Naebi, Seyed Hossein Mirpour, Arman Keymoradzadeh, Seyedeh Elham Norollahi

BioMedicine

Colorectal cancer (CRC) is distinguished by epigenetic elements like DNA methylation, histone modification, histone acetylation and RNA remodeling which is related with genomic instability and tumor initiation. Correspondingly, as a main epigenetic regulation, DNA methylation has an impressive ability in order to be used in CRC targeted therapy. Meaningly, DNA methylation is identified as one of most important epigenetic regulators in gene expression and is considered as a notable potential driver in tumorigenesis and carcinogenesis through gene-silencing of tumor suppressors genes. Abnormal methylation situation, even in the level of promoter regions, does not essentially change the gene expression levels, particularly …

The Judet Quadricepsplasty For Elderly Traumatic Knee Extension Contracture: A Case Report And Review Of The Literature, Benjamin Tze Keong Ding, Suheal Ali Khan

BioMedicine

Traumatic injuries to the knee are frequently complicated by extension contractures. The Judet Quadricepsplasty allows for controlled, sequential release of extrinsic and intrinsic knee contracture components while reducing the potential for iatrogenic quadriceps rupture. We document our institutions experience with this procedure and a systematic review of the current literature. We followed up on an elderly patient with posttraumatic flexion contracture that failed conservative management and underwent Judet Quadricepsplasty. Her knee range of motion improve dramatically from 20 degrees of flexion to 100 degrees of flexion. There was a residual extension lag of 5 degrees which did not impede on …

Cohort Study Of Microelement Status In “Healthy” Population Of Russian Megapolis, Andrew K. Martusevich, Konstantin A. Karuzin

BioMedicine

The aim of the study was at the cohort assessment of microelement status in large city residents classified as “apparently healthy people”. The population study included 2,025 randomly selected middle-aged (2045 years) persons without chronic diseases or acute infectious pathologies. The set of subjects was standardized by age and gender. A blood sample was taken once from each person to determine concentrations of microelements. The level of peripheral blood microelements were determined by atomic absorption spectrometry using «Shimadzu AA7000» device (Japan). The study of a large population of city residents demonstrated inhomogeneity in their microelement status. Deficit conditions were found …

Development Of Broad Spectrum Mycosporine Loaded Sunscreen Formulation From Ulva Fasciata Delile, Saurabh Bhatia, Satish Sardana, Ajay Sharma, Celia Bertha Vargas De La Cruz, Bhupal Chaugule, Laleh Khodaie

BioMedicine

Ba.ckground: Sunscreen formulations primarily offer protection against UV induced damages however nowadays it also maintains skin natural physiological conditions. Current global market is flooded with numerous sunscreen products which offer protection to skin against several UV induced damages. However most of these sunscreen formulations offers narrow spectrum protection against UV and also suffer from stability as well as toxicity related issues.

Methods: Present work aims to isolate mycosporine amino acid (Mgy) from green alga namelyUlva fasciata (U. fasciata)and study its sunscreen potential against widely used domestic marketed formulation. Stability evaluations were also performed for almost 90 days.

Results: Results demonstrated …

In Vivo Microdialysis And In Vitro Hplc Analysis Of The Impact Of Paeoniflorin On The Monoamine Levels And Their Metabolites In The Rodent Brain, Yuh-Tzy Lin, Wei-Shih Huang, Huei-Yann Tsai, Min-Min Lee, Yuh-Fung Chen

BioMedicine

Background: Paeoniflorin (PF) possesses several effects such as analgesic, the anti-spasmodic effect on smooth muscle. It protects the cardiovascular system and reveals the neuroprotective effect on cerebral ischemia. Monoamine system has been identified to have complex regulatory effects in pain signaling. There are no reports regarding the impact of PF on monoamine levels in the rodent brain by microdialysis. In this study, the effects of PF on monoamines and their metabolites in the rodent brain usingin vivomicrodialysis andin vitrohigh performance liquid chromatography (HPLC) analysis.

Methods: Male S.D. rats were anesthetized, fixed onto the stereotaxic instrument to identify the positions of …

Materials And Structures Used In Meniscus Repair And Regeneration: A Review, Ketankumar Vadodaria, Abhilash Kulkarni, E Santhini, Prakash Vasudevan

BioMedicine

No abstract provided.