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Mitigating Neuroinflammation In Cognitive Areas: Exploring The Impact Of Hmg-Coa Reductase Inhibitor, Carlos Henrique Rocha Catalão, Luis Henrique Angenendt Da Costa, Jonathas Rodrigo Dos Santos, Luciane Carla Alberici, Luiz Luciano Falconi-Sobrinho, Norberto Cysne Coimbra, Diogo Dominguini, Felipe Dal-Pizzol, Tatiana Barichello, Maria José Alves Rocha Nov 2024

Mitigating Neuroinflammation In Cognitive Areas: Exploring The Impact Of Hmg-Coa Reductase Inhibitor, Carlos Henrique Rocha Catalão, Luis Henrique Angenendt Da Costa, Jonathas Rodrigo Dos Santos, Luciane Carla Alberici, Luiz Luciano Falconi-Sobrinho, Norberto Cysne Coimbra, Diogo Dominguini, Felipe Dal-Pizzol, Tatiana Barichello, Maria José Alves Rocha

Faculty, Staff and Student Publications

Existing literature suggests that infection-specific mechanisms may play a significant role in the onset and progression of dementia, as opposed to the broader phenomenon of systemic inflammation. In addition, 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A (CoA) reductase inhibitors have been proposed as a potential therapeutic approach for sepsis, given their anti-inflammatory and antioxidant properties. We investigated the neuroprotective effect of an HMG-CoA reductase inhibitor (simvastatin) by analyzing neurodegenerative markers, mitochondrial respiration, and neuronal tracing in the prefrontal cortex (PFC) and thalamic nucleus reuniens (RE) of sepsis survivor animals. Adult Wistar rats were subjected to sepsis by cecal ligation and puncture or left non-manipulated. …


Robust Voltage Regulation For Dc Microgrids Via Passivity-Based Sliding Mode Control, Edoardo Vacchini, Michele Cucuzzella, Pablo Borja, Antonella Ferrara Nov 2024

Robust Voltage Regulation For Dc Microgrids Via Passivity-Based Sliding Mode Control, Edoardo Vacchini, Michele Cucuzzella, Pablo Borja, Antonella Ferrara

School of Engineering, Computing and Mathematics

This paper proposes a decentralized sliding mode control approach to the voltage regulation problem in a DC microgrid consisting of distributed generation units interconnected with each other through resistive-inductive power lines and supplying unknown nonlinear loads. In particular, the port-Hamiltonian structure of the system suggests the design of a suitable sliding manifold such that the system on this manifold exhibits desired passivity properties. This approach simplifies the control design and relaxes some restrictive assumptions required by other controllers proposed in the literature, while offering satisfactory performance.


Hany Mahhmoud As Administrator Of The Estate Of Gaber Mahmoud V. Aviles Nov 2024

Hany Mahhmoud As Administrator Of The Estate Of Gaber Mahmoud V. Aviles

All Decisions

In this nonpayment proceeding, the court issued an Interim Order to Correct, requiring the landlord to address multiple housing code violations, including mold and a broken toilet, within specific timeframes. The court found that the uninhabitable conditions in the apartment, including the broken toilet, necessitated the issuance of a Class C violation. This order was issued without prejudice to the landlord's defenses in an anticipated Housing Part proceeding brought by the tenant.


High-Coverage Nanopore Sequencing Of Samples From The 1000 Genomes Project To Build A Comprehensive Catalog Of Human Genetic Variation, Jonas A Gustafson, Sophia B Gibson, Nikhita Damaraju, Miranda P G Zalusky, Kendra Hoekzema, David Twesigomwe, Lei Yang, Anthony A Snead, Phillip A Richmond, Wouter De Coster, Nathan D Olson, Andrea Guarracino, Qiuhui Li, Angela L Miller, Joy Goffena, Zachary B Anderson, Sophie H R Storz, Sydney A Ward, Maisha Sinha, Claudia Gonzaga-Jauregui, Wayne E Clarke, Anna O Basile, André Corvelo, Catherine Reeves, Adrienne Helland, Rajeeva Lochan Musunuri, Mahler Revsine, Karynne E Patterson, Cate R Paschal, Christina Zakarian, Sara Goodwin, Tanner D Jensen, Esther Robb, 1000 Genomes Ont Sequencing Consortium, University Of Washington Center For Rare Disease Research (Uw-Crdr), Genomics Research To Elucidate The Genetics Of Rare Diseases (Gregor) Consortium, William Richard Mccombie, Fritz J Sedlazeck, Justin M Zook, Stephen B Montgomery, Erik Garrison, Mikhail Kolmogorov, Michael C Schatz, Richard N Mclaughlin, Harriet Dashnow, Michael C Zody, Matt Loose, Miten Jain, Evan E Eichler, Danny E Miller Nov 2024

High-Coverage Nanopore Sequencing Of Samples From The 1000 Genomes Project To Build A Comprehensive Catalog Of Human Genetic Variation, Jonas A Gustafson, Sophia B Gibson, Nikhita Damaraju, Miranda P G Zalusky, Kendra Hoekzema, David Twesigomwe, Lei Yang, Anthony A Snead, Phillip A Richmond, Wouter De Coster, Nathan D Olson, Andrea Guarracino, Qiuhui Li, Angela L Miller, Joy Goffena, Zachary B Anderson, Sophie H R Storz, Sydney A Ward, Maisha Sinha, Claudia Gonzaga-Jauregui, Wayne E Clarke, Anna O Basile, André Corvelo, Catherine Reeves, Adrienne Helland, Rajeeva Lochan Musunuri, Mahler Revsine, Karynne E Patterson, Cate R Paschal, Christina Zakarian, Sara Goodwin, Tanner D Jensen, Esther Robb, 1000 Genomes Ont Sequencing Consortium, University Of Washington Center For Rare Disease Research (Uw-Crdr), Genomics Research To Elucidate The Genetics Of Rare Diseases (Gregor) Consortium, William Richard Mccombie, Fritz J Sedlazeck, Justin M Zook, Stephen B Montgomery, Erik Garrison, Mikhail Kolmogorov, Michael C Schatz, Richard N Mclaughlin, Harriet Dashnow, Michael C Zody, Matt Loose, Miten Jain, Evan E Eichler, Danny E Miller

Faculty, Staff and Students Publications

Fewer than half of individuals with a suspected Mendelian or monogenic condition receive a precise molecular diagnosis after comprehensive clinical genetic testing. Improvements in data quality and costs have heightened interest in using long-read sequencing (LRS) to streamline clinical genomic testing, but the absence of control data sets for variant filtering and prioritization has made tertiary analysis of LRS data challenging. To address this, the 1000 Genomes Project (1KGP) Oxford Nanopore Technologies Sequencing Consortium aims to generate LRS data from at least 800 of the 1KGP samples. Our goal is to use LRS to identify a broader spectrum of variation …


Spatiotemporal Mapping Of Auditory Onsets During Speech Production, Garret Lynn Kurteff, Alyssa M Field, Saman Asghar, Elizabeth C Tyler-Kabara, Dave Clarke, Howard L Weiner, Anne E Anderson, Andrew J Watrous, Robert J Buchanan, Pradeep N Modur, Liberty S Hamilton Nov 2024

Spatiotemporal Mapping Of Auditory Onsets During Speech Production, Garret Lynn Kurteff, Alyssa M Field, Saman Asghar, Elizabeth C Tyler-Kabara, Dave Clarke, Howard L Weiner, Anne E Anderson, Andrew J Watrous, Robert J Buchanan, Pradeep N Modur, Liberty S Hamilton

Faculty, Staff and Students Publications

The human auditory cortex is organized according to the timing and spectral characteristics of speech sounds during speech perception. During listening, the posterior superior temporal gyrus is organized according to onset responses, which segment acoustic boundaries in speech, and sustained responses, which further process phonological content. When we speak, the auditory system is actively processing the sound of our own voice to detect and correct speech errors in real time. This manifests in neural recordings as suppression of auditory responses during speech production compared with perception, but whether this differentially affects the onset and sustained temporal profiles is not known. …


Device On A Vehicle For Integrating A Music Guessing Game, Marcel Stranz Nov 2024

Device On A Vehicle For Integrating A Music Guessing Game, Marcel Stranz

Defensive Publications Series

The core of the idea is that the vehicle offers an integrated music guessing game in the HMI and that the game can preferably be played using data from the vehicle. The display and processing should preferably take place via the HMI in the vehicle.


What Is In Your Drink? How Ingredient Lists For Alcoholic Beverages Would Protect Persons With Food Allergies, Benjamin Leraris Nov 2024

What Is In Your Drink? How Ingredient Lists For Alcoholic Beverages Would Protect Persons With Food Allergies, Benjamin Leraris

DePaul Law Review

No abstract provided.


Upstream Lawyering: A Framework For Poverty Law, L. Kate Mitchell Nov 2024

Upstream Lawyering: A Framework For Poverty Law, L. Kate Mitchell

DePaul Law Review

No abstract provided.


Fear Of The Storm, Jerome South Nov 2024

Fear Of The Storm, Jerome South

Night Flight: Online Literary Journal

No abstract provided.


The Lunch Counter, Joeseph Shears Nov 2024

The Lunch Counter, Joeseph Shears

Night Flight: Online Literary Journal

No abstract provided.


Gmr-216 Ai/Ml-Based Water Quality Monitoring Mobile App For Predicting E.Coli In Surface Waters, Keerthi Priya Karumanchi Nov 2024

Gmr-216 Ai/Ml-Based Water Quality Monitoring Mobile App For Predicting E.Coli In Surface Waters, Keerthi Priya Karumanchi

C-Day Computing Showcase

E.coli contamination in surface waters has proven to be a significant public health concern, requiring innovative monitoring solutions. This paper presents the design of an AI-driven mobile application to predict whether E.coli bacteria are present at levels exceeding acceptable thresholds in surface waters. The methodology employs sensor devices to collect water quality data parameters, such as water temperature, pH, dissolved oxygen, and turbidity. A dataset is generated based on these parameters, and machine learning (ML) algorithms are applied to evaluate accuracy, precision, recall, and processing time. Additionally, our ML algorithms establish a correlation matrix among water quality parameters to identify …


Uc-173 Leveraging Large Language Models To Empower Caretakers Of People With Dementia, Mercy Olaniran, Emily A Centeno Nov 2024

Uc-173 Leveraging Large Language Models To Empower Caretakers Of People With Dementia, Mercy Olaniran, Emily A Centeno

C-Day Computing Showcase

Behavioral symptoms of Alzheimer's Disease and Related Dementias (ADRD) are detrimental to the quality of life for individuals with ADRD and their caregivers. Symptoms such as wandering, agitation, and confusion can often overwhelm caregivers leading to stress, depression, or burnout which can lead to a decrease in the quality of care. These challenges often result in increased hospitalizations and care costs, creating a need for a solution to support informal caregivers. This project proposes the development of an AI-based Dementia Care Voice Assistant application to meet the needs of caregivers. Using large language models, the application will provide real-time and …


Uc-180 Intelligent Object Retrieval Using Mobile Manipulator, Zhiwen Zheng, Ellie Ireland Nov 2024

Uc-180 Intelligent Object Retrieval Using Mobile Manipulator, Zhiwen Zheng, Ellie Ireland

C-Day Computing Showcase

A mobile manipulator for intelligent object retrieval is presented. The system was integrated using state of the art R&D hardware and software, which implemented autonomous navigation, object recognition, and object pose estimation based optimal grasping. The retrieval of an object of interest is commanded that involves subsequent object detection and recognition while autonomously navigating using the known map and starting from an arbitrary position. From close proximity, object pose estimation based optimal grasp is selected to pick up the object. The object is retrieved back to the start position in this scenario. An 84% trial-phase precision in object retrieval is …


Ur-147 An 8-Bit Digital Computer Design & Implementation (Team Coa-Wm1), Adrian L Sherard, Jesus Flores, Biswash Lamsal, Blake Hammontree, William Pitts Nov 2024

Ur-147 An 8-Bit Digital Computer Design & Implementation (Team Coa-Wm1), Adrian L Sherard, Jesus Flores, Biswash Lamsal, Blake Hammontree, William Pitts

C-Day Computing Showcase

8 bit computer design using NI multisim


Gmr-208 Automatic Categorization Of Behavioral Health Issues In Police Reports, Mason V Pederson, Abm Adnan Azmee, Francis E Nweke Nov 2024

Gmr-208 Automatic Categorization Of Behavioral Health Issues In Police Reports, Mason V Pederson, Abm Adnan Azmee, Francis E Nweke

C-Day Computing Showcase

911 is often the first place contacted for dealing with behavioral health related (BHR) issues. Its estimated at least a fifth of all calls are related to behavioral health, and with BHR affected convicts having a recidivism rate of around 30%, its not hard to see how straining these issues can become on systems already stretched thin, where chronic understaffing is often a reality. A great solution would be if we could intervene as soon as possible to get people the treatment they need, police reports would be excellent for identifying and treating these individuals, but annotation is a long …


Gmr-210 Cogni-Resource: Ai-Driven Reflective Feedback Analysis For Enhanced Learning Insights And Resource Discovery, Ashrith Kumar Devara Nov 2024

Gmr-210 Cogni-Resource: Ai-Driven Reflective Feedback Analysis For Enhanced Learning Insights And Resource Discovery, Ashrith Kumar Devara

C-Day Computing Showcase

Cogni-Resource is a unified platform enhanced by AI that merges the introspective analysis of Cogni-Reflect with the precise resource exploration functions of the Learning Resource Finder, providing a holistic tool to improve educational environments. The Cogni-Reflect component uses advanced Large Language Models (LLMs) to examine student reflections, giving educators instant insights into learning results, difficulties, and areas where students may require extra assistance. Cogni-Reflect allows instructors to adjust their teaching by analyzing key themes and topics in reflective narratives, leading to a more adaptive and successful learning atmosphere. Using both web scraping and OpenAI API integration, the Learning Resource Finder …


Gpr-6128 Joint Encryption And Error Correction For Quantum Communication, Nitin Jha Nov 2024

Gpr-6128 Joint Encryption And Error Correction For Quantum Communication, Nitin Jha

C-Day Computing Showcase

Secure quantum networks are foundational for developing a quantum internet in the future. However, current age quantum channels are prone to noise, which can introduce errors in transmitted data. Traditionally, error correction is applied to the message separately, after encryption, resulting in additional overhead that should be minimized. In response, we propose a unified approach that combines encryption and error correction into a single process. This work represents an initial effort to integrate these functions for secure quantum communication by integrating the Calderbank-Shor-Steane (CSS) Quantum Error Correction (QECC) code with the three-stage secure quantum communication protocol. Additionally, the protocol supports …


Best Practices For Hybrid Art Museum Programs For People With Dementia, Pooja Lalwani, Sujal Manohar, Jessica Kay Ruhle Nov 2024

Best Practices For Hybrid Art Museum Programs For People With Dementia, Pooja Lalwani, Sujal Manohar, Jessica Kay Ruhle

International Journal of Lifelong Learning in Art Education

The Reflections program at the Nasher Museum of Art at Duke University offers art gallery tours for adults with dementia and their care partners. Originally an in-person program, Reflections adapted to a virtual model during the COVID-19 pandemic and now utilizes a hybrid model with in-person and online programs. Surveys distributed to Reflections’ participants indicate the benefits of having both in-person and virtual options post-pandemic. Anecdotal survey data and participation statistics show high engagement and satisfaction with the current hybrid mode. Literature about hybrid art education programs for people with dementia remains limited. We offer best practices and insights for …


Intergenerational Art: A Cultural Perspective, Steve Willis Nov 2024

Intergenerational Art: A Cultural Perspective, Steve Willis

International Journal of Lifelong Learning in Art Education

This paper will present the experiences that I had with two female Elders in the Acoma Pueblo. By working with a traditional Acoma family, I gained an intimate view of the positionality of the family structure, intergenerational teaching, and the Acoma culture. Like my experiences with many Eastern Tribes (my ancestral lineage is with the Powhaton Society), the Acoma culture is a matrilineal society. This paper will include anecdotal narratives along with images of the Pueblo, Sky City, and traditional ceramic forms. I will present the sacredness of the environment through art-making and art-sharing between generations. The two Acoma Elders …


Connections: Full Journal Nov 2024

Connections: Full Journal

International Journal of Lifelong Learning in Art Education

No abstract provided.


Rifles And Rivals: A Study Of The Domestic Effects On American Military Policy, Rachel Warren Nov 2024

Rifles And Rivals: A Study Of The Domestic Effects On American Military Policy, Rachel Warren

The Dialogue

Rachel Warren analyzes the domestic forces shaping U.S. military foreign policy in the post-Cold War era. The paper evaluates the roles of political polarization and the military-industrial complex, using quantitative analysis to assess their influence on legislative decisions​


A Texas Tradition: Analyzing Texas' Commitment To Capital Punishment, Grace E. Brandt Nov 2024

A Texas Tradition: Analyzing Texas' Commitment To Capital Punishment, Grace E. Brandt

The Dialogue

Grace Brandt examines Texas' historical and ongoing support for capital punishment. The paper explores the evolution of execution methods, legislative frameworks, and public opinion, emphasizing the cultural and political factors sustaining the death penalty in Texas despite national trends towards abolition


Iraq, Democracy, And The United States Nov 2024

Iraq, Democracy, And The United States

The Dialogue

This collaborative paper by Kevin Matejka, Arnaud Zimmern, and Lara Vidal examines the complexities of promoting democracy in Iraq and other Muslim-majority nations. The authors analyze different perspectives on democracy's compatibility with Islamic principles and explore Western and Middle Eastern viewpoints. Through an exploration of political theory and historical context, they provide insights into the challenges and prospects for democratization in the region, particularly in light of U.S. involvement


Can China Finally Follow-Through On Its Commitments, Christina Almeida Nov 2024

Can China Finally Follow-Through On Its Commitments, Christina Almeida

The Dialogue

Christina Almeida assesses China's adherence to WTO intellectual property commitments. Since joining the WTO in 2001, China has continued to infringe on intellectual property rights (IPR) of U.S. firms, resulting in significant economic losses. Almeida discusses factors such as state capitalism and insufficient enforcement mechanisms within China that hinder compliance. The paper recommends a multi-faceted approach, including bilateral trade mechanisms and stricter WTO oversight, to address China's ongoing IPR violations​


Cross-Party Voting In 21st Century Presidential Primaries: A Social And Empirical Analysis, Mark Trautmann Nov 2024

Cross-Party Voting In 21st Century Presidential Primaries: A Social And Empirical Analysis, Mark Trautmann

The Dialogue

This paper by Mark Trautmann explores the phenomenon of cross-party voting in U.S. presidential primaries, focusing on its prevalence and impact in open primaries. Trautmann examines cases in the Midwest, analyzing data and media narratives surrounding the Michigan Republican Primary (2000, 2012) and the Democratic Primaries in Wisconsin (2004) and Indiana (2008). The findings suggest that while media often overemphasizes the influence of cross-party voting, its actual effect on primary outcomes remains limited, though potentially disruptive in certain cases


Stability Of The Chinese Government, Fairooz Adams Nov 2024

Stability Of The Chinese Government, Fairooz Adams

The Dialogue

Fairooz Adams analyzes the internal and external factors influencing the stability of the Chinese Communist Party since the Tiananmen Square incident. The paper argues that while China has become more stable through economic growth and co-opting business elites, underlying issues like corruption and social defiance pose significant risks. Adams balances a historical overview with contemporary challenges to evaluate the resilience of the regime​


Two Constructions Of Liberty: Hugo Black's And Robert Jackson's Stances On Free Speech, Adam Mueller Nov 2024

Two Constructions Of Liberty: Hugo Black's And Robert Jackson's Stances On Free Speech, Adam Mueller

The Dialogue

Adam Mueller contrasts the interpretations of free speech by Justices Hugo Black and Robert Jackson. The paper explores how their differing philosophies of liberty influenced their judicial decisions, particularly in the context of Cold War tensions and fears of extremism. Mueller examines the broader implications of their stances for constitutional democracy​


From The Editor, Brenda Machosky Nov 2024

From The Editor, Brenda Machosky

Antipodes

From the Editor


Red-Handed: Assessing The Deptha Of Chinese Economic Espionage, Alexander Hoskins Nov 2024

Red-Handed: Assessing The Deptha Of Chinese Economic Espionage, Alexander Hoskins

The Dialogue

Alexander Hoskins investigates China's involvement in economic espionage (EE). The paper differentiates EE from industrial espionage and competitive intelligence gathering, highlighting the significant global impact of China's alleged theft of intellectual property, which has economic and geopolitical consequences


Melba Padilla Maggay, A Clash Of Cultures: Early American Protestant Missions And Filipino Religious Consciousness, Brian Paul Giron Nov 2024

Melba Padilla Maggay, A Clash Of Cultures: Early American Protestant Missions And Filipino Religious Consciousness, Brian Paul Giron

Budhi: A Journal of Ideas and Culture

Melba Padilla Maggay, A Clash of Cultures: Early American Protestant Missions and Filipino Religious Consciousness