Digital Commons Network^™

Bottlebrush Polymer Conjugates For Enhanced Antisense Oligonucleotide Therapy In Myotonic Dystrophy Type 1, Yao Li, Gyu Seong Heo, Yongjian Liu, Et Al.

2020-Current year OA Pubs

Oligonucleotides are a promising class of genetic medicine for myotonic dystrophy type 1 (DM1), the most common adult-onset muscular dystrophy. However, poor muscle distribution of nucleic acid drugs following systemic administration has hindered drug development, and no curative treatment currently exists. DM1 pathology requires drug localization to the nucleus, where pathogenic mutant RNA is sequestered, posing additional challenges after cellular internalization regarding endosomal escape and nuclear uptake. Here, we show that a locked nucleic acid oligonucleotide targeting mutant CUG repeat RNA tracts, conjugated to a bottlebrush polymer, exhibits improved muscle distribution and potent correction of DM1-associated splicing dysregulation in a …

Butterfly Taxa Discovery Via Genomic Analysis, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Expanding a genomics-guided assessment of butterfly taxonomy, we integrate phylogenetic evidence from all protein-coding genes with morphological considerations to refine our understanding of butterfly systematics and discover new taxa. As a result, 2 subgenera, 39 species, and 5 subspecies are proposed as new (type species in original combinations or type localities are listed in parentheses): Erebia (Magda) magdalena uintana Grishin, ssp. n. (USA: Utah, Uintah Co.) in Nymphalidae Rafinesque, 1815; Myselasia rondea Grishin, sp. n. (Brazil: Rondônia), Myselasia pseudocrinon Grishin, sp. n. (Ecuador: Pastaza), Myselasia paramatuta Grishin, sp. n. (Ecuador: Morona-Santiago), Euselasia anapellos Grishin, sp. n. (Peru: Loreto), …

Colostrum Management For Dairy Calves: Key Practices For Calf Health And Performance, Drew Swartz, Jacob Hadfield, Kalen Taylor, Maggi Mathews

All Current Publications

This fact sheet provides practical recommendations for dairy producers to improve colostrum management and support calf health and performance.

Disability Stigma, Disability Identity, And Psychological Distress Among Young Adults With Disabilities, Dylan G. Serpas

USF Tampa Graduate Theses and Dissertations

Disability discrimination is positively associated with psychological distress. Internalized disability stigma or the extent to which negative beliefs about one’s disability become personally adopted is implicated as a mediator. Moreover, disability identity processes, including identity affirmation and rejection may shape downstream consequences of navigating disability discrimination and internalization processes. These relationships are particularly relevant among young adults with disabilities (YAWD) who navigate a critical developmental period characterized by identity formation and heightened perception to social evaluation. In this study, 233 YAWD aged 18 to 25 completed a cross-sectional survey measuring disability microaggressions, internalized disability stigma, disability identity (rejection and affirmation), …

Program (Pdf), Department Of Orthopaedics

Dept. of Orthopaedics: Robert D. D’Ambrosia Lectureship & Research Day

Program with abstracts for the 22nd Annual Dept of Orthopaedics Annual Robert D. D’Ambrosia Lectureship & Research Day held June 20, 2026.

A Storm-Ai Primer With An Operationally Representative Example, Shiu-Kai Chin, Matthew Clark, Garrett Katz, Jae C. Oh, William Young

Electrical Engineering and Computer Science - All Scholarship

A STORM-AI Primer with an Operationally Representative Example presents the Systems-Theoretic Technical and Operational Risk Management with Artificial Intelligence (STORM-AI) methodology, a transdisciplinary framework for establishing the trustworthiness of mission systems that may incorporate AI components. The core value proposition of STORM-AI is mission assurance—ensuring that mission systems behave with the predictability and proportionality required by senior leadership and demanded by international humanitarian law. STORM-AI achieves this by faithfully preserving commander's intent from high-level mission descriptions down to hardware-level behavioral specifications through a structured sequence of four formally grounded models: a Mission Model, a Protection (Loss Control) Model, a Security …

Enhancing Emotional Support For Advanced Placement Students, Laine Mckay Nesbitt

Theses and Dissertations

Although they may struggle with their emotional well-being, academically accelerated students are underrepresented in the research literature. Teachers are in a position to influence students' emotional well-being. Minimal qualitative research with student voices has been conducted. This study highlights the perspectives of students who have participated in an academically accelerated program. Students were interviewed about what their teachers do to help or hinder their emotional well-being and what they wish that teachers could do to support their emotional well-being. A total of 14 high school students were interviewed using the critical incident technique (CIT). The participants emphasized the importance of …

Respect And Aggression In Intimate Relationships: A Grounded Theory Of Relational Responsiveness, Aaron T. Fife

Theses and Dissertations

The negative effects of aggression in intimate relationships have been well documented through research and clinical literature (Lawrence & Bradbury, 2001; Shortt et al., 2006). Conversely, the positive effects of respectful behavior are well-known (Gottman, 1994; Dew & Wilcox, 2013). This important dimension of relationships is crucial to understanding what makes up healthy and unhealthy relationships. However, little is known about how couples understand the varying types of respect and aggression within intimate relationships, nor how they are lived and experienced relationally. The purpose of this study is to explore the dyadic processes behind respect and aggression as well as …

Toward Passwordless Document Encryption, Isaac Henry Teuscher

Theses and Dissertations

Document files with sensitive information are used across nearly every industry. In recent years, cyberattacks targeting cloud-based file transfer applications have resulted in millions of sensitive documents being exposed. Although document encryption methods exist, they are often limited in usability, security, or deployability. Password-based encryption, the most widely available option, remains vulnerable to brute-force attacks, unauthorized sharing, and human error. We address these gaps in three phases. First, we present a structured comparative framework adapted from the usability-deployability-security model to evaluate nine document encryption methods across 15 design properties, identifying the benefits and limitations of current approaches. Second, we design …

A Lesson In Class: How Parents' Class Identity Changes Relate To Children's Exposure To Social Classes -- A Latent Profile Analysis, L. Caroline Moore

Theses and Dissertations

Class inequality in the United States has reached levels not seen since the late 1920s. This inequality has been linked to numerous harmful societal outcomes and may be particularly detrimental for children, who often experience limited intergroup contact with individuals from different social class backgrounds. Drawing on Social Identity Theory and the significant role parents play in shaping children's social environments, this study examined how White and Black parents' changes in perceived social class from childhood to adulthood relate to the ways they prioritize exposing their children to different social class environments (N = 702, U.S. sample). Latent Profile Analysis …

This One's For The Girls: Co-Creating A Social Confidence Group Intervention For Autistic Adolescent Girls, Kendra Noelle Zitzman

Theses and Dissertations

Numerous studies have been completed regarding social confidence-building interventions for individuals with autism. However few studies have studied autistic females' experience with social confidence and targeted interventions for their unique needs. The purpose of this study was to co-create a social confidence curriculum with adolescent and young adult autistic females based on their experiences, perceived strengths and weaknesses, and goals. We analyzed first-person experiences and perceptions about social confidence-building interventions and supports. We used pre- and post-group interviews of the adolescent autistic participants (n =11) and college-aged mentors (n = 4), pre- and post-group measures with the Social Responsiveness Scale, …

Influence Of Timed Repeated Readings On Grade 2 French Immersion Students' Reading Fluency And Comprehension, Kathryn Rosie Baldwin

Theses and Dissertations

This study examined the effects of Timed Repeated Reading (TRR) on reading fluency, comprehension, and reading attitudes among second grade students in a French Dual Language Immersion (DLI) program in Utah. Forty-one students from two pre-existing classroom groups participated over 11 weeks, with one class receiving TRR and the other serving as a control. Fluency was measured in correct words per minute (CWPM), comprehension through cloze tests, and attitudes using a seven-item affective survey with a four-point visual scale. A mixed between-within subjects ANOVA analysed pre- and post-test data across four intervals. Results showed significant fluency gains over time for …

Beyond The Bell Curve: Understanding Native American Academic Placements, Sarah-Margaret Clark

Theses and Dissertations

This study examined biases regarding the referrals that teachers make regarding student placement recommendations for Native American students. Special education teachers (n = 97) from around the United States completed a digital card sort task involving 24 fictitious student record cards. The student record cards contained subtle information about the ethnicity of the student, as indicated through the use of racial identification (Native American, Asian, or White) on the student records and the use of student names that may be associated with these three categories. Academic information was equal among each of these three groups. Each group contained identical male …

Calibration And Validation Of An Ogden Material Model For Thermoplastic Polyurethane In 3d-Printed Tensegrity Structures, Caleb C. Swain

Theses and Dissertations

This work is motivated by ongoing efforts within the Smart Materials, Adaptronics, and Shock Laboratory (SMASH Lab) at Brigham Young University (BYU) to develop variable-stiffness, external fixators using 3D-printed tensegrity structures. In the process of designing and evaluating these systems, the need arose to accurately model the nonlinear mechanical behavior of thermoplastic polyurethane (TPU), the primary material used in prototype fabrication. This thesis investigates how accurately a calibrated Ogden material model can predict the nonlinear mechanical response of TPU in 3D-printed tensegrity structures. Experimental data were used to calibrate the parameters of the hyperelastic constitutive model through nonlinear optimization. An …

An Access-Control Logic In Hol (Trindemossen 2), Shiu-Kai Chin

Electrical Engineering and Computer Science - All Scholarship

This manual documents the embedding of an access-control logic (ACL) — as presented in the textbook Access Control, Security, and Trust: A Logical Approach (Chin and Older, 2011) — within the Cambridge Higher-Order Logic theorem prover HOL-4. The logic is a multi-agent modal logic with Kripke semantics. Its purpose is to reason about authentication, authorization, integrity, security, and trust. The inference rules of the ACL are proved to be sound. The inference rules are a command-and-control (C2) calculus. The value of the ACL is its support for rigorous, verified, and trustworthy policies for complete mediation, i.e., where all actions are …

Integration Of Intraoperative Data In Interpretable Machine Learning Models To Predict Postoperative Aki In Noncardiac Surgery Patients, Justin Do, Karan H. Shah, Melissa Xu, Andrew Hyunwoo Kim, Vivaswat Suresh, Nidhir Guggilla, Michael Li, Rishi Kothari

Department of Anesthesiology Faculty Papers

OBJECTIVES: We aimed to (1) quantify changes in discrimination when adding intraoperative data to preoperative data and (2) compare tabular machine learning with feature engineering against a time-aware LSTM-based model.

MATERIALS AND METHODS: Retrospective cohort of 46 204 adults undergoing 57 055 eligible noncardiac surgery in the INSPIRE database. We extracted 38 preoperative and 49 intraoperative variables; acute kidney injury (AKI) was defined by KDIGO serum creatinine criteria and modeled as stage 2/3 postoperative AKI. Models were trained on preoperative-only and combined pre- and intraoperative data. Intraoperative series were summarized using eight statistical features for tabular models or integrated directly …

Quality Improvement Project: The Impact Of A Safety Coach Program In A Pediatric Intensive Care Unit, Royanne Lickliter

Doctor of Nursing Practice Projects

Patient safety remains a critical concern in healthcare, with hospital-acquired conditions (HACs) contributing to preventable harm, mortality, and increased costs, particularly in high-acuity settings such as Pediatric intensive care units (PICUs). A recent safety culture survey at a tertiary pediatric hospital identified gaps in proactive safety behaviors, communication, and psychological safety. The primary problem identified was inconsistent engagement in proactive safety practices and limited frontline empowerment to identify and mitigate risks in real time. The purpose of this quality improvement (QI) project was to evaluate the impact of implementing a structured Safety Coach Program in the PICU on HAC rates, …

Exploring Generative Artificial Intelligence Perceptions And Information Retrieval Behaviors Among Students: An Investigation Of Google Search And Chatgpt Queries, Annie Kiele Brown

Theses and Dissertations

Generative AI tools are rapidly reshaping how undergraduate students seek and engage with academic information, yet empirical understanding of what drives adoption and how students behave when using these tools relative to traditional search engines remains limited. This study examined undergraduate students’ information-retrieval behaviors and perceptions when using ChatGPT compared to Google Search, using the technology acceptance model (TAM; Davis, 1989) extended to include trust (Gefen et al., 2003) as the guiding framework. An embedded mixed-methods design was employed, in which Likert-scale perception ratings provided a structured quantitative signal and thematic analysis of semi-structured interviews, structured information-retrieval tasks, and concurrent …

Unlocking Potential: Teachers' Perspectives On 504 Accommodations For Students With Adhd, Haley Stubbs

Theses and Dissertations

This study examined high school teachers' perspectives on the development, implementation, and effectiveness of Section 504 accommodations for students with ADHD. Five secondary teachers from a public high school participated in a focus group, and data were analyzed using inductive thematic analysis. Findings indicate that teachers report limited understanding of the 504 process, minimal involvement in eligibility decisions, and little training on how to implement accommodations. Teachers describe accommodations as vague and difficult to apply consistently within the constraints of secondary classrooms, often relying on universal classroom practices and student self-advocacy to meet student needs. Teachers also question whether accommodations …

Teaching Intercultural Communicative Competence (Icc) At The Afl Novice Level: Teachers’ Practices And Constraints, Nancy Fahmy

Theses and Dissertations

Intercultural Communicative Competence (ICC) is widely recognized as a core objective in language education; however, its implementation in novice-level Arabic as a Foreign Language (AFL) classroom remains insufficiently examined. This study explores what strategies do AFL teachers use to integrate ICC principles at the beginner level (A1–A2), the constraints that shape classroom practice, teachers’ assessment approaches, and perceived professional development needs.

Using an explanatory sequential mixed-methods design, quantitative data were collected through a bilingual (Arabic–English) online survey completed by 54 AFL teachers working across instructional contexts in Egypt, Jordan, the United Kingdom, and the Netherlands. Qualitative data were subsequently gathered …

Patients Willingness To Seek Help From Pharmacists In The Management Of Rheumatoid Arthritis: A Qualitative Study, Omkar Ghodke, Erin Holmes, Meagen Rosenthal, Yinan Huang, Marie Barnard

Podiums

Background: This study explored the willingness of rheumatoid arthritis (RA) patients to seek help from pharmacists for their disease management. While pharmacist interventions are known to enhance medication adherence and health outcomes, patient engagement with pharmacists remains low. Understanding the factors that influence RA patients' willingness to use pharmacy services is essential for improving patient outcomes and optimizing the role of pharmacists in RA management. Using the Integrative Model of Behavioral Prediction (IMBP), this study identified the factors influencing willingness to use pharmacists and pharmacy services among patients with RA. Methods: This study utilized semi-structured interviews targeting individuals 26 years …

Multilevel Drivers Of Missed Opportunities For Hiv Prevention: A Qualitative Synthesis Within A Systematic Review, Ismaeel Yunusa, Tarilate Temedie-Asogwa, Osaro Mgbere, Julie Atta, Moosa Tatar, Susan Abughosh, Ekere Essien

Posters

Background: Despite the availability of effective HIV prevention strategies, including pre-exposure prophylaxis (PrEP), gaps in prevention delivery persist across healthcare settings. Missed opportunities for HIV prevention remain common, yet multilevel factors driving these gaps are not fully understood. Understanding these drivers is essential to inform effective interventions at the individual, interpersonal, provider, and system levels. Objectives: To identify and synthesize multilevel determinants of missed opportunities for HIV prevention and PrEP delivery. Methods: We conducted a qualitative synthesis within a systematic review of U.S.-based studies (2012-2025) on missed opportunities for HIV prevention. Articles were identified through database searches (PubMed, Embase, and …

Knowledge, Attitudes, And Practices Toward Pharmacovigilance And Adverse Drug Reaction Reporting Among Healthcare Professionals In Iraq: A Cross-Sectional Study, Hajir Karim Abdul-Husseein, Noor Abdalwahd Abood, Karam Akram Al-Akkam

Hilla University College Journal For Medical Science

Background: Pharmacovigilance is critical for approving medication safety; yet, underreporting of adverse drug reactions (ADRs) remains common.

Objectives: This cross-sectional study aimed to assess the knowledge, attitudes, and practices of healthcare professionals in Karbala and Babylon, Iraq, using a structured paper-based questionnaire.

Materials and Methods: This study utilized healthcare professionals in Holy Karbala and Babylon to explore their demographic profiles, pharmacovigilance knowledge, attitudes, and reporting practices. Results: Among 194 participants, most demonstrated positive attitudes toward ADR reporting, but notable gaps in knowledge and reporting behavior were observed. Pharmacists showed significantly higher knowledge levels than other professions, and formal training was …

Fragile Hope And The Cultural Life Of Law, Shefali Jain

Socio-Legal Review

This review of Sandhya Fuchs’ Fragile Hope: Seeking Justice for Hate Crimes in India (Stanford University Press 2024) highlights that the book makes a genuinely original ethnographic and conceptual contribution to caste studies and hate crime scholarship. At the same time, the essay argues that there are three limitations to its framework that require greater engagement: the book’s failure to engage with the legal consciousness tradition in socio-legal scholarship, an underdeveloped account of “legal meliorism,” and an unresolved tension between the book’s stated commitment to victim-centred analysis and its ethnographic evidence that frequently discusses movement-level aspirations.

On Crucial Role Of The Spirit Of Chinese Scientists In Basic Research, Xin Wang, Chuanxi Wang, Changpu Sun

Bulletin of Chinese Academy of Sciences (Chinese Version)

Basic research is the source of original innovation and the foundation for building a strong nation in science and technology. Compared with applied development research and engineering research, basic research is primarily concerned with exploring the frontiers, proposing new concepts, discovering new laws, and establishing new theories. Its outcomes are often difficult to predict in advance and are rarely subject to sufficient experimental and practical verification within a short time frame. These characteristics expose basic research to three inherent challenges in the philosophy of science. First, the experimental verification of fundamental theories often requires a long period of time. Second, …

Engineering 3d Optical Interconnects And Low-Power Radio Frequency Gaze Tracking, Blake P. Crosby

Theses and Dissertations

This thesis presents two independent research works in optical in- terconnects and radio-frequency (RF)-based gaze tracking. The first work demonstrates a silicon optical waveguide fabricated from four through-silicon vias (TSVs) produced using two-photon-absorption- assisted photo-electrochemical etching. Unlike conventional TSV fabrica- tion methods, this approach enables highly localized, non-line-of-sight etching in silicon using a focused femtosecond laser. Four approximately 5 μm diameter TSVs were etched through a 200 μm silicon wafer in a 7 μm by 7 μm pattern, leaving a central silicon region that functions as a waveguide. The fabricated structure achieved an aspect ratio of approxi- mately 40:1 with …

2026-06-20 Commencement Struggle Prompts Outcry Over Palestine And Treatment Of Muslim Students, Dylan Berman, Tristan Scott

The Spectator Online

No abstract provided.

From Unfinished Sentences To Unfinished Degrees: A Reflection On Students’ Struggles With Academic Writing In The Context Of Retention In Higher Institutes Of Education, Irina Ruppo

Irish Journal of Academic Practice

This article explores the experiences and beliefs of students whose struggles with academic writing had led to contemplation of withdrawal from the university. It proposes that the absence of writing as a separate factor in existing retention models obscures the importance of writing issues to students’ persistence with their chosen course of study. Through a qualitative analysis of in-depth interviews with undergraduate students, the article suggests that students’ struggles with writing may be distinct from their overall difficulties with the workload. Four beliefs about academic writing are identified as potentially contributing to the students’ malintegrative experience within the institution. Seeing …

Retirement At Risk: The Political Economy Of Public Pension Governance, Allen Mendenhall, Dan Sutter

Journal of New Finance

State public pension systems manage over $6 trillion in assets while facing approximately $1.3 trillion in unfunded liabilities, raising fundamental questions about governance effectiveness and fiduciary accountability. This Article examines these challenges through the analytical framework of governance, applying insights from public choice, principal-agent models, and corporate governance to argue that details in implementation significantly impact outcomes.  We offer Ohio’s State Teachers Retirement System (STRS) as a case study. Recent governance reforms in Ohio—including legislative restructuring of the STRS board and enactment of fiduciary standards legislation modeled on the American Legislative Exchange Council’s framework—suggest the potential for earlier governance problems. …

Analyzing Retirement Systems Through A Triad Framework: Lessons For U.S. Reform, Romina Boccia, Ivane Nachkebia

Journal of New Finance

As U.S. Social Security approaches insolvency, this paper analyzes the program’s challenges through a political economy lens and makes two new contributions. First, it introduces a normative triad framework for evaluating retirement systems based on individual autonomy, fiscal sustainability, and poverty alleviation. Second, it applies this framework to five advanced economies—Canada, Germany, New Zealand, Sweden, and the U.S.—to identify institutional features associated with differences in outcomes. Deriving implications for U.S. reform, we propose four recommendations: transition Social Security to a flat-benefit system, slow benefit growth, adopt automatic stabilizers, and expand flexible savings options.