Digital Commons Network^™

Utility Of Candidate Genes From An Algorithm Designed To Predict Genetic Risk For Opioid Use Disorder, Christal N Davis, Alexander S Hatoum, Arpana Agrawal, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Recently, the US Food and Drug Administration gave premarketing approval to an algorithm based on its purported ability to identify individuals at genetic risk for opioid use disorder (OUD). However, the clinical utility of the candidate genetic variants included in the algorithm has not been independently demonstrated.

OBJECTIVE: To assess the utility of 15 genetic variants from an algorithm intended to predict OUD risk.

DESIGN, SETTING, AND PARTICIPANTS: This case-control study examined the association of 15 candidate genetic variants with risk of OUD using electronic health record data from December 20, 1992, to September 30, 2022. Electronic health record …

Brain Age Modeling And Cognitive Outcomes In Young Adults With And Without Sickle Cell Anemia, Andria L Ford, Slim Fellah, Yan Wang, Kira Unger-Levinson, Maria Hagan, Martin N Reis, Amy Mirro, Josiah B Lewis, Chunwei Ying, Kristin P Guilliams, Melanie E Fields, Hongyu An, Allison A King, Yasheng Chen

2020-Current year OA Pubs

IMPORTANCE: Both sickle cell anemia (SCA) and socioeconomic status have been associated with altered brain structure and cognitive disability, yet precise mechanisms underlying these associations are unclear.

OBJECTIVE: To determine whether brains of individuals with and without SCA appear older than chronological age and if brain age modeling using brain age gap (BAG) can estimate cognitive outcomes and mediate the association of socioeconomic status and disease with these outcomes.

DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study of 230 adults with and without SCA, individuals underwent brain magnetic resonance imaging (MRI) and cognitive assessment. Brain age was estimated using DeepBrainNet, …

T Helper 2 Cell-Directed Immunotherapy Eliminates Precancerous Skin Lesions, Tomonori Oka, Neel S. Raval, Mary Tabacchi, Lynn A. Cornelius, Et Al.

2020-Current year OA Pubs

The continuous rise in skin cancer incidence highlights an imperative for improved skin cancer prevention. Topical calcipotriol-plus-5-fluorouracil (calcipotriol-plus-5-FU) immunotherapy effectively eliminates precancerous skin lesions and prevents squamous cell carcinoma (SCC) in patients. However, its mechanism of action remains unclear. Herein, we demonstrate that calcipotriol-plus-5-FU immunotherapy induces T helper type 2 (Th2) immunity, eliminating premalignant keratinocytes in humans. CD4+ Th2 cells were required and were sufficient downstream of thymic stromal lymphopoietin cytokine induction by calcipotriol to suppress skin cancer development. Th2-associated cytokines induced IL-24 expression in cancer cells, resulting in toxic autophagy and anoikis followed by apoptosis. Calcipotriol-plus-5-FU immunotherapy was dependent …

A Single-Cell Compendium Of Human Cerebrospinal Fluid Identifies Disease-Associated Immune Cell Populations, Claudia Cantoni, Roman A. Smirnov, Maria Firulyova, Prabhakar S. Andhey, Tara R. Bradstreet, Ekaterina Esaulova, Marina Terekhova, Elizabeth A. Schwarzkopf, Nada M. Abdalla, Maksim Kleverov, Anne H. Cross, Maxim N. Artyomov, Brian T. Edelson, Gregory F. Wu, Et Al.

2020-Current year OA Pubs

Single-cell transcriptomics applied to cerebrospinal fluid (CSF) for elucidating the pathophysiology of neurologic diseases has produced only a preliminary characterization of CSF immune cells. CSF derives from and borders central nervous system (CNS) tissue, allowing for comprehensive accounting of cell types along with their relative abundance and immunologic profiles relevant to CNS diseases. Using integration techniques applied to publicly available datasets in combination with our own studies, we generated a compendium with 139 subjects encompassing 135 CSF and 58 blood samples. Healthy subjects and individuals across a wide range of diseases, such as multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease, …

Comparison Of Cardiorespiratory Fitness Testing Measures In Children, Trey R. Naylor, Mariana V. Jacobs, Michael C. Taylor Jr., Jody L. Clasey

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 65-78, 2025. There is currently an exponential increase in the prevalence of childhood obesity thus warranting the demand to appropriately measure and evaluate cardiorespiratory fitness within educational settings. The aims of this study were to (1) compare measured peak oxygen consumption (VO₂peak), heart rate peak (HRpeak), and 1-min heart rate recovery (HRRec) responses obtained using a GXTmax and the PACER test; and (2) compare the VO₂peak from the GXTmax and PACER test to a PACER prediction equation (ScottEqua). Methods: This study included 32 (16 boys) children. Despite not having maturational …

The Effects Of Augmented Feedback, Focus Of Attention, And Monetary Reward On Vertical Jump Height: A Replication Study, Javad Bakhshinejad, Jasmin C. Hutchinson, Jennifer Murphy, Lydia Trainor, Sarah Friedman, Nicholas Coker

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 13-26, 2025. Reproducibility and replicability of published empirical scientific evidence are fundamental for verifying key findings, identifying errors and/or boundary conditions, and upholding rigorous research standards. For this replication study, the primary goal was to assess the replicability of the findings from Wälchli et al. (2016), which investigated the role of augmented feedback (AF), external focus of attention (EF), and reward (RE), as well as a combination of these conditions on countermovement jump height. The original study sample included 18 resistance-trained male and female participants, while this replication included 38 (19 male, 19 female). …

Yoga Vs. Static Stretching: Recovery Impact On Male Athletes’ Post-Hiit Heart Rate, Respiratory Rate, Blood Pressure, And Heart Rate Variability Analysis, Haruthai Petviset Dr., Sasima Pakulanon Dr., Suppalerk Rusmeeroj, Buris Rukdang

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 79-91, 2025. Heart rate and heart rate variability indicate an athlete's cardiovascular recovery and autonomic balance after intense exercise. While stretching aids recovery, its effects on autonomic balance are inconsistent. Yoga’s combination of postures, breathing, and relaxation may further activate the parasympathetic system, making it a promising tool for sports recovery. This study employed a crossover design to examine the effects of yoga and stretching on post 30-min session of high-intensity interval training (HIIT) recovery in male athletes. Twenty athletes of Mae Fah Luang University (Age 20.95±0.99 years old, VO2max 42.53±4.79 ml/kg/min) were given …

The Psychometric Performance Of State Mindfulness Scales Around Sitting And Walking On Desert Trails: A Pilot Study, Dustin W. Davis, Elias M. Malek, Rob Salatto, Marcus M. Lawrence, Jacob W. Manning, Mark Debeliso, Merrill R. Landers, Graham Mcginnis, James W. Navalta

International Journal of Exercise Science

International Journal of Exercise Science 18(4): 27-42, 2025. State mindfulness is a dynamic construct reflecting current mindfulness, or purposeful attention to the present moment with openness, non-judgment, non-reactivity, and acceptance. Despite its popularity and research in psychology and medicine, measuring state mindfulness remains a challenge. Validity and reliability of the State Mindfulness Scale (SMS) and State Mindfulness Scale for Physical Activity (SMS-PA) in applied settings like nature require more data to be established. This pilot study aimed to evaluate these scales and introduce a new, one-item scale, the Visual Analog Scale-Mindfulness (VAS-M), for quicker mindfulness assessment. Participants completed the SMS, …

The Relationship Between Lower-Body Flexibility And Running Performance In A Half Marathon Downhill Running Event, Logan Petty, Marcus M. Lawrence

International Journal of Exercise Science

International Journal of Exercise Science 18(3): 1-12, 2025. Although previous studies examining treadmill or relatively flat overground running events have found relationships for running performance and flexibility, no study has examined these outcomes during downhill events, including between sexes. Therefore, the purpose of this study was to determine if a relationship exists between lower body flexibility and running performance in recreational adult male and female distance runners competing in a downhill half marathon race. Recreational (n=11 male, n=19 female) adult distance runners completed this study. On the day prior to the race, participants performed a standardized warm-up, …

Optimizing Underground Construction And Plan Management For The Mong Duong Coal Mine, Vietnam, Phi Hung Nguyen, Thi Kim Thanh Nguyen, Duc Hung Pham, Quang Phuc Le, Thai Tien Dung Vu

Journal of Sustainable Mining

Mong Duong mine’s output objective is 1.5 million tons, which requires approximately 10,000 m of tunnel excavation each year. Because of the complicated geological features, the actual work is vastly different, necessitating regular changes in design and technical approaches, as well as plans for material supply, money, and staff. On the other hand, office personnel visit the construction site to update the work status after each report, and the department head and board of directors make choices on development and execution. This process takes time because it is carried out manually. As a result, a solution to support the optimization …

Spatiotemporal Variation Of Vegetation Cover In Mining Areas Of Ysr Kadapa District, Andhra Pradesh Using Remote Sensing And Gis, Vinod Kumar Yarlanki, Prudhvi Raj Muppala, Prem Kumar Yasam, Balaji Gollapudi, Sumanth Moddu, Appanna Besta

Journal of Sustainable Mining

The spatiotemporal variation of vegetation cover in the mining areas of YSR Kadapa district, Andhra Pradesh, using Remote Sensing and GIS techniques. By focusing on the years 2014, 2018, and 2023, the analysis provides insights into changes observed in water bodies, bare soil, sparse vegetation, moderate vegetation, and dense vegetation. The results reveal dynamic trends in land cover categories, highlighting the environmental impact of mining activities in the region. A significant decline in water bodies is observed, with the area reducing from 3.48 km² in 2014 to 1.91km² in 2023. This decrease raises concerns about the potential degradation …

Assessing The Perception Gap: Mining Impacts From Community And Company Perspectives In Nigeria, Ikechukwu Mbachu

Journal of Sustainable Mining

The study intends to evaluate how mining companies and their host communities perceive the impacts of mining operations and to ascertain if there are significant differences in how both parties perceive the impacts of mining in Nigeria. The study was carried out in twelve states in Nigeria and covered the six geopolitical zones in Nigeria. Data was collected through a questionnaire and interviews carried out separately with community members and company representatives. The study investigated ten categories of mining impacts such as socioeconomic, environmental, health, physical and so on. To gauge the perceptions of the respondents on the different impact …

Leveraging Intrinsic Properties For Classification Of Coal Seams Towards Spontaneous Combustion Proclivity And Predicting Susceptibility Using Machine Learning: Smart And Sustainable Mining Approach, Siddhartha Agarwal, Pradeep K. Gautam, Yuhao Zou, Rishabh Dwivedi, D.C. Panigrahi, C. Dagli, Atul Singh

Journal of Sustainable Mining

Mine fires and other hazards caused by spontaneous coal combustion are a pervasive and longstanding issue in Jharia coalfields, India. This study proposes a novel approach to classify coal seams based on their propensity to spontaneous combustion using the intrinsic properties of 30 coal samples from different seams. This method eliminates the need for expensive and time-consuming experimental determinations of susceptibility indices (SI) such as crossing point temperature (CPT), critical air blast (CAB), and differential thermal analysis (DTA). All clustering models, viz. hierarchical, k-means, and multidimensional scaling, aptly classify coal seams into three categories: highly risky, medium risky, and low …

An Automated Integrated Web-Based Smart Tool For Open Stope Design, Yerkezhan Madenova, Fidelis Suorineni, Shuai Xu

Journal of Sustainable Mining

The Stability Graph is a widely used tool for the design of open stopes in underground mining. Many users of the Stability Graph still apply this design method manually. Although the manual approach has benefits, using multiple graphs and stability number computation charts for each stope surface is time-consuming, even for the experienced mining engineer. Current practice in the use of the method also limits data sharing. This paper presents a StopeSoft web-based tool for open stope stability prediction that is developed on the basis of the Stability Graph method and is available at openstope.com. StopeSoft incorporates flexibility in terms …

Ensnared By Custom: Mary Astell And The American Bar Association On Female Autonomy, Judy Cornett

Book Chapters

Rhetoric—the arts of practical discourse that we broadly define as the use of symbols to influence belief and action—has something to say about contemporary legal theory and practice. Law and rhetoric in the West were born together nearly 2500 years ago in the Mediterranean. American law has eschewed its rhetorical roots since the late nineteenth century. Denying law’s rhetorical nature helps to construct an impartial façade, shoring up law’s legitimacy. Admitting the rhetorical nature of law would be to admit its partiality, or the point of view inevitably inscribed with every textual choice. At the same time, rhetorical theorists have …

Education For Citizenship In Times Of Global Challenge: Iea International Civic And Citizenship Education Study 2022 International Report, Wolfram Schulz, John Ainley, Julian Fraillon, Bruno Losito, Gabriella Agrusti, Valeria Damiani, Tim Friedman

Civics and Citizenship Assessment

This open access book investigates the ways in which young people around the world are prepared to undertake their roles as citizens. It presents the international results from the third cycle of the study IEA’s International Civic and Citizenship Education Study (ICCS 2022). Based on data from 24 countries or benchmarking participants from Europe, Latin America, and Asia, ICCS 2022 studies contexts for and learning outcomes of civic and citizenship education in a wide range of national contexts at the beginning of the third decade of the 21st Century. It responds to both enduring and emerging challenges of educating young …

“Restating” The Record: Evaluating Ali’S Aided-By-Agency Disclaimer, Danielle Dascher

Staff Publications

No abstract provided.

Eisenhower, Wilson, And Professional Baseball In Kansas, Revised, Mark E. Eberle

Monographs

Ever since General Dwight David Eisenhower mentioned in 1945 that he had played professional baseball under the pseudonym Wilson sometime after his 1909 graduation from Abilene High School, there have been attempts to document this assertion. Yet, he offered little detail for researchers to follow, not even the team or year. If true, however, it has been speculated this would have made him ineligible for intercollegiate competition in 1911–1915 while he attended the US Military Academy at West Point, New York, where he played on the football team. Thus, interest in the story has persisted. Newspaper accounts of baseball mention …

Bert Wakefield And The End Of Integrated Minor League Baseball In Kansas, Revised, Mark E. Eberle

Monographs

Bert Wakefield was a lifelong resident of Troy, Kansas, where he was an active member of the community—business owner, member of social organizations, and musician. Wakefield was also an African American who played on several integrated and Black baseball teams through the 1890s and early 1900s, including the Chicago Unions, Chicago Union Giants, Algona (Iowa) Brownies, Renville (Minnesota) All-Stars, and the original Kansas City Monarchs. In addition, Wakefield served as the captain of the predominantly white Troy minor league team in the Kansas State League in 1895. In this role, he joined Bud Fowler as the only Black players to …

Alfred “Army” Cooper: A Baseball Career With The 25th Infantry, Negro Leagues, And Tournament Teams, Revised, Mark E. Eberle

Monographs

Lefthanded pitcher Alfred “Army” Cooper was born in Kansas City, Kansas in 1899 and had a long career with Black baseball clubs between the First and Second World Wars. He played baseball while serving with the 25th US Infantry Regiment in Nogales, Arizona during most of the 1920s. After his discharge in February 1928, he pitched for the Kansas City Monarchs of the Negro National League until 1930. The following year, he played for several weeks with Gilkerson’s Union Giants, a prominent barnstorming team, before rejoining the independent Kansas City Monarchs as they barnstormed through the end of the summer. …

Baseball Career Of Andy Cooper In Kansas, Revised, Mark E. Eberle

Monographs

Andrew Lewis Cooper was inducted into the National Baseball Hall of Fame in 2006. He was a lefthanded pitcher, who played and managed in the Negro Leagues from 1920 until his death in 1941, mostly for the Detroit Stars and Kansas City Monarchs. Cooper also played baseball in California, Cuba, and the Far East. However, his life before 1920 has been little studied. Andy Cooper was born in Texas, probably in 1897. Although he was a resident of Waco and began playing baseball in northern Texas, contemporary newspaper reports document an African American pitcher from Texas named Andrew “Lefty” Cooper …

Shattered Windows: The Story Of Genora Johnson Dollinger, Eva Stone, And The Women Of Michigan, Brett Kovel

Master's Theses and Doctoral Dissertations

The thesis, Shattered Windows, explores the significant roles of Genora Johnson Dollinger and Eva Stone in Michigan’s labor movements during the 1930s. It focuses on Dollinger’s leadership in the Flint Sit-Down Strike of 1936-37, where she mobilized women to join the picket lines, culminating in the formation of the Women’s Emergency Brigade. Her influence extended beyond Flint, inspiring women across Michigan to challenge corporate power and defend workers’ rights. Following Dollinger’s example, Eva Stone led protests against rising meat prices, further uniting women in economic activism. This work examines the unique contributions of these women, situating their efforts within a …

Navigating Uncertainty As An “Adolescent Organization”: Addressing The Needs Of Lgbtqiaa+ Young People In A Complex And Adaptive Service Organization, Suzie Staley

Master's Theses and Doctoral Dissertations

Throughout history, lesbian, gay, Transgender, queer/questioning, intersex, asexual, and agender plus Students have been marginalized in society and, in particular, K-12 schools. The purpose of this qualitative study was to explore the experiences of young adults and recent high school graduates to gather information about their experience in K-12 educational environments to determine if their developmental needs were met. This study focused on youth who attended K-12 schools in a specific district in Southeast Michigan and participated in out-of-school time programs at a local teen center. Through in-depth interviews with youth participants and focus groups with teen center staff and …

Scalable And Ethical Insider Threat Detection Through Data Synthesis And Analysis By Llms, Haywood Gelman, John Hastings

Research & Publications

Insider threats wield an outsized influence on organizations, disproportionate to their small numbers. This is due to the internal access insiders have to systems, information, and infrastructure. Signals for such risks may be found in anonymous submissions to public web-based job search site reviews. This research studies the potential for large language models (LLMs) to analyze and detect insider threat sentiment within job site reviews. Addressing ethical data collection concerns, this research utilizes synthetic data generation using LLMs alongside existing job review datasets. A comparative analysis of sentiment scores generated by LLMs is benchmarked against expert human scoring. Findings reveal …

Anita Guerrini '75-Kathy Paxton-Williams '85, Anita Guerrini, Kathy Paxton-Williams

Alumni Oral History Project

No abstract provided.

A Phenomenological Study Exploring Superintendent’S Perceptions On Four Servant Leadership Characteristics For Developing High-Performing Teams, Katie Chin-Berry

Dissertations

Purpose: The purpose of this phenomenological study was to explore and describe public school superintendents’ perceived impact of four servant leadership characteristics established by Spears (2010) on developing and maintaining high-performing teams. Methodology: This phenomenological research study explored and detailed how superintendents perceived the influence of four servant leadership characteristics on developing and maintaining high-performing teams. Eight participants were chosen using nonprobability purposeful and convenience sampling based on specific criteria, which required at least 4 years of experience in their district, a minimum of 10 years of experience in the K–12 public school system, and employed in a K–12 district …

Leadership’S Impact On Employees’ Perception Of Their Safety Culture In A Public Transportation Organization, Paul Hadley

Dissertations

Purpose: This nonexperimental quantitative study aimed to examine the relationship between various leadership styles using the Multifactor Leadership Questionnaire (MLQ; Bass & Avolio, 1995) and employees’ perceptions of their organization’s safety culture based on a developed Safety Perception Questionnaire (SPQ) within the context of a public transportation agency. Methodology: This study used a quantitative approach to collect data from employees in a public transportation agency. Leadership characteristics were assessed using the MLQ, which is a self-report tool designed to measure three distinct leadership styles. The employees’ MLQ scores were correlated with their results on the SPQ, which evaluates perceptions of …

Board Of Editors And Table Of Contents, California Western Law Review

California Western Law Review

No abstract provided.

Quiet As Maus - Are Obscenity Laws Directed At School Libraries Silencing Children's First Amendment Protections?, Gabrielle Mark-Bachoua

California Western Law Review

No abstract provided.

How To Retain Being A Human Lawyer While Using Generative Ai, David King

California Western Law Review

No abstract provided.