Digital Commons Network^™

Leadership Development In Millennial Corporate Employees With Nonnative Accents, Clara Philor

Walden Dissertations and Doctoral Studies

Employees with nonnative accents sometimes avoid leadership roles, engage less in the workplace, and perform poorly. Organizational leaders need to understand how the challenges of individuals with nonnative accents specifically affect millennials. Grounded in attribution theory and social identity theory, the purpose of this qualitative study was to explore how millennial employees with nonnative accents experience leadership opportunities in the corporate workplace. The participants were 10 millennial corporate employees in the United States with nonnative accents working toward or already holding leadership positions. Data were collected using in-depth interviews for thematic and interpretive phenomenological analysis. Seven themes emerged: (a) challenges …

Staff Education To Improve Phq-9 Depression Screening In Primary Care, Adella Kweyila

Walden Dissertations and Doctoral Studies

The staff education project aimed to address the gap in practice regarding the use of the PHQ-9 depression screening tool in a primary care setting. The providers at the setting demonstrated variations in screening practices leading to potential missed opportunities for early depression identification and treatment. This Doctor of Nursing Practice project explored the question: “What is the effect of implementing a staff education program to improve staff knowledge to effectively implement changes that affect the use of the PHQ-9 screening tool to improve depression identification and treatment of adult patients in a primary care clinic?” This project aimed to …

Software Developer, Analyst, And Consultant Communication Strategies In Enterprise Resource Planning Projects, Martin Gene Culberson

Walden Dissertations and Doctoral Studies

Enterprise resource planning (ERP) software projects have an alarmingly high failure rate, with communication challenges cited as a major contributing factor. Poor communication during ERP development and implementation can ultimately reduce return on investment (ROI) for organizations. IT technical and functional specialists have a vested interest in improving communication strategies to enhance ERP success, ensuring business continuity, operational efficiency, and professional growth for project participants. Grounded in actor-network theory, the purpose of this pragmatic inquiry was to examine communication strategies used in ERP software projects among software developers, analysts, and consultants. The participants were eight ERP developers, analysts, and consultants …

Spartan Daily, February 12, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 9

The Mir-290 And Mir-302 Clusters Are Essential For Reprogramming Of Fibroblasts To Induced Pluripotent Stem Cells, Robert L Judson-Torres, Robert Blelloch

Faculty, Staff and Students Publications

The miR-290 and miR-302 clusters of microRNAs are highly expressed in naïve and primed pluripotent stem cells, respectively. Ectopic expression of the embryonic stem cell (ESC)-specific cell cycle regulating family of microRNAs arising from these two clusters dramatically enhances the reprogramming of both mouse and human somatic cells to induced pluripotency. Here, we used genetic knockouts to dissect the requirement for the miR-290 and miR-302 clusters during the reprogramming of mouse fibroblasts into induced pluripotent stem cells (iPSCs) with retrovirally introduced Oct4, Sox2, and Klf4. Knockout of either cluster alone did not negatively impact the efficiency of reprogramming. Resulting cells …

In Vivo Expansion Of Gene-Targeted Hepatocytes Through Transient Inhibition Of An Essential Gene, Mingming Cao, Ayrea Hurley, Lavanya Saxena, Marcel A Chuecos, Christopher J Walkey, Alexandria M Doerfler, Mia N Furgurson, M Cecilia Ljungberg, Kalyani R Patel, Sarah Hyde, Tyler Chickering, Stephanie Lefebvre, Kelly Wassarman, Patrick Miller, June Qin, Mark K Schlegel, Ivan Zlatev, Jun Han, Christine Beeton, Rich Gang Li, Jong Kim, James F Martin, Karl-Dimiter Bissig, Vasant Jadhav, Gang Bao, William R Lagor

Faculty, Staff and Students Publications

Homology directed repair (HDR)-based genome editing is an approach that could permanently correct a broad range of genetic diseases. However, its utility is limited by inefficient and imprecise DNA repair mechanisms in terminally differentiated tissues. Here, we tested “Repair Drive”, a platform technology for selectively expanding HDR-corrected hepatocytes in adult mice in vivo. Repair Drive involves transient conditioning of the liver by knocking down an essential gene – fumarylacetoacetate hydrolase (Fah), and delivery of an untargetable version of the essential gene in cis with a therapeutic transgene. We show that Repair Drive increased the percentage of correctly …

Designing Patient-Centered Interventions For Emergency Care: Participatory Design Study, Jiaqi Li, Zhan Zhang, Hardeep Singh, Kalyan Pasupathy, Prashant Mahajan, Sun Young Park

Faculty, Staff and Students Publications

Background: Emergency departments (EDs) are high-pressure environments where clinicians diagnose patients under significant constraints, including limited medical histories, severe time pressures, and frequent interruptions. Current ED care practices often inadequately support meaningful patient participation. Most interventions prioritize clinical workflow and health care provider communication, inadvertently overlooking patients' needs. Additionally, patient-facing technologies in EDs are typically developed without meaningful patient input, leading to solutions that may not effectively address patients' specific challenges. To enhance both patient-centered care practices and the diagnosis process in EDs, patient involvement in technology design is essential to ensure their needs during emergency care are understood and …

Clinical Importance Of Phenytoin Monitoring To Reduce Phenytoin-Related Toxicity In Saudi Patients With Epilepsy, Ghidaa Alwaf, Hussam Younis, Mohammed Al-Hartani, Alaa H. Falemban, Et.Al.

Saudi Toxicology Journal

Background: Phenytoin toxicity can result from overdose, dosage changes, drug interac-tions, or physiological alterations. Symptoms range from nausea and confusion to severe cases involving coma and seizures, though fatalities are rare. To date, no literature has been found concerning phenytoin monitoring in Saudi epileptic patients. This study is the first to inves-tigate phenytoin monitoring for toxicity prevention, optimal dosing, and adverse effect management in Saudi epileptic patients. Methods: A two-month, randomized, open-label, prospective monitoring study was conducted in Saudi epileptic patients treated with phen-ytoin. The patients (n=40) were subdivided into two groups (monitored and unmonitored) to check the prevalence of …

Efficacy And Safety Of Nivolumab Plus Ipilimumab In Patients With Metastatic Variant Histology (Non-Clear Cell) Renal Cell Carcinoma, Mohammad Jad Moussa, Jaanki Khandelwal, Nathaniel R Wilson, Kiran L Malikayil, Devaki Shilpa Surasi, Yiyun Lin, Pheroze Tamboli, Kanishka Sircar, Helen Ajufo, Khaled M Elsayes, Amishi Shah, Andrew C Johns, Sangeeta Goswami, Elshad Hasanov, Eric Jonasch, Pavlos Msaouel, Matthew T Campbell, Omar Alhalabi, Nizar M Tannir

Faculty, Staff and Student Publications

Background: Nivolumab plus ipilimumab (nivo/ipi) is a standard of care first-line (1 L) therapy for patients with metastatic clear-cell renal cell carcinoma (ccRCC), but its role in patients with metastatic, non-ccRCC has not been fully defined. We report a single-institution experience with nivo/ipi in non-ccRCC.

Methods: Between November 2017 and February 2024, 55 patients with metastatic non-ccRCC received nivo/ipi at MD Anderson Cancer Center. The tumor response was assessed by blinded radiologists using RECIST v1.1. The overall response rate (ORR), progression-free survival (PFS), PFS milestone, duration of response (DoR), and overall survival (OS) were determined. Next-generation sequencing (NGS) was performed …

2025-02-12 Shen Ren Works With Cryopreservation In Hopes For A Better Future, Abdullah El-Sherbeeny

The Spectator Online

No abstract provided.

Contribution Of Rare Chromosome 22q112 Copy Number Variants To Non-Syndromic Bicuspid Aortic Valve, Helene Digregorio, Sara Mansoorshahi, Steven G Carlisle, Catherina Tovar Pensa, Abi Watts, Courtney Mcneely, Anna Sabate-Rotes, Anji Yetman, Hector I Michelena, Julie F A De Backer, Laura Muiño Mosquera, Malenka M Bissell, Maria Grazia Andreassi, Ilenia Foffa, Dawn S Hui, Anthony Caffarelli, Yuli Y Kim, Rodolfo Citro, Margot De Marco, Justin T Tretter, Kim L Mcbride, Simon C Body, Dianna M Milewicz, Siddharth K Prakash, Ebav Investigators

Faculty, Staff and Student Publications

Background: Bicuspid aortic valve (BAV) is the most common congenital heart defect in adults, often leading to complications such as thoracic aortic aneurysms and aortic stenosis. While BAV is frequently associated with 22q11.2 deletion syndrome (22q11.2DS), the contribution of rare copy number variants (CNVs) in this region to non-syndromic BAV is less clear. This study is aimed to assess the role of rare 22q11.2 CNVs in patients with early-onset BAV (EBAV) and to determine whether these variants are linked to an increased risk of complications.

Methods: Whole genome microarray genotyping was conducted on 272 patients with BAV with early onset …

A Comparison Between The Traditional And Novel Isometric Mid-Thigh Methods And The Relationship To Countermovement Jump Performance, Meir Magal, Jay R. Hoffman, Matan Amitay

International Journal of Exercise Science

International Journal of Exercise Science 18(3): 226-238, 2025. The isometric mid-thigh pull (IMTP) test using the traditional bar grip (BAR) is a reliable and effective measure of strength performance in different populations. In addition, IMTP performance has been linked to jump performance. Recent research has shown that the pelvic belt (PEL) IMTP method produces higher absolute and relative peak force values than the Bar IMTP method. However, limited scientific data has examined the PEL IMTP method performance data and its relationship to dynamic strength and sports performance. The study aimed to provide a more robust comparison between the BAR and …

Age-Related Infertility And Reproductive Tourism In Annarita Briganti’S Novel Non Chiedermi Come Sei Nata, María Reyes Ferrer

Journal of International Women's Studies

Traditional socio-cultural constructions of womanhood have often focused on women’s reproductive capacity, which has determined their destiny and shaped their identity over centuries. Given the long-time equation of motherhood and women’s identity, infertility is an important topic that raises question about how women experience infertility and how science, through advances in assisted reproduction, has intervened in the creation of life. In the European context, Italy has one of the lowest birth rates, a phenomenon attributable to a series of adverse structural conditions. In particular, precarious work conditions, insufficient wage levels, and a high cost of living represent significant obstacles to …

(De)Constructing Desperation: The Dargah Of Bu Ali Shah Qalandar As A Site Of Emotional Wellbeing For Infertile Women, Shahida Shahida

Journal of International Women's Studies

Infertility is a health issue that requires serious consideration due to its impact on the social, emotional, and economic wellbeing of the affected individual. Despite the development of assisted reproductive technology (ART) that has successfully enabled conception, these methods are not universally accessible to all women. There can be many roadblocks in an individual’s journey that go beyond medical domains. Studies have indicated that, when paired with medical treatment, spiritual healing practices and religious interventions can have a positive effect on the emotional health of those struggling to conceive. This study employs a narrative approach to document the lived experiences …

The Chair Side Forsus Appliance: A Novel Approach To Correcting Class Ii Malocclusions In Adolescents, Thiagasirpi M, Saravanakumar S, Prema Anbarasu, Saravana Dinesh

Annual Research Symposium

No abstract provided.

Ever-Increasing Statistics Of Police Response To Mental Health Crisis Calls: Best Practices, Lauren Olson

Master of Arts in Criminal Justice Leadership

This paper explores the evolving role of police officers in addressing mental health crises, emphasizing the challenges and ethical dilemmas they face due to insufficient training and resources. It highlights the need for specialized training, ethical guidelines, and collaboration with mental health professionals to equip officers better and ensure public safety.

The paper advocates for policy and practice shifts to address the growing demands on law enforcement in mental health situations. The rising trend of mental health calls presents significant challenges for police officers, who often lack the resources and training to provide appropriate assistance, resulting in higher incarceration rates …

We Feel, We Understand: Examining The Moderating Effects Of Publics' Empathy On Crisis Outcomes Across Crisis Types And Response Strategies, James Ndone

Communication, Media, and Culture

This study examines how empathy, operationalized into affective and cognitive dimensions, influences stakeholders' perceptions during organisational crises. Also, the study explores the mediating role of account acceptance in the relationship between crisis response strategies and organisational outcomes. An online three (crisis type: victim vs. accidental vs. preventable) × two (crisis response strategy: apology vs. denial) between-subjects experimental design with 686 participants randomly assigned to different crises (victim, accidental, preventable) and response strategy (apology, denial) was conducted. The findings reveal that account acceptance mediates the relationship between crisis response strategies and key organisational outcomes such as reputation, forgiveness, and purchase intention. …

“These Are Not Ordinary Criminals!” The First War Crimes Trial At The People's Tribunal And Its Implications In Post-Holocaust Romania, Stefan Cristian Ionescu

History Faculty Articles and Research

This article examines the neglected war crimes trials of Holocaust perpetrators that took place at the People's Tribunal in early postwar Romania, focusing especially on the first trial (the “Macici group”). The article shows that in spite of the political interferences by the new pro-communist regime and the USSR, the Macici group trial in particular, and the first war crimes trials in general, were not Stalinist show trials or fake trials and they sentenced real war criminals and accurately captured Romania's participation in the Holocaust. Unlike the Antonescu group trial – that indicted the former pro-Nazi dictator and his closest …

Rocky Bucano, Mark Naison

Oral Histories

Abstract by Serena Vasquez

Interviewer: Mark Naison, Stephanie Robinson-Ramirez, Ryan Purcell

Interviewee: Rocky Bucano

Rocky Bucano, founder of the Hip-Hop Museum, a longtime music producer, and an administrator for the Gauchos AAU basketball program, as well as having worked in television, multimedia, artist management, DJing, promotion, radio, and marketing grew up in the Valley. Born in the US, Bucano’s father, Ernesto, was a merchant seaman from Panama who worked on steamships as a stoker, and his mother, Dorothy, was a high press operator in the fashion district from Saint Kitts. Bucano describes the monumental occurrence of when his family moved …

Mapping Of Qtls Associated With Frost Tolerance In Olive (Olea Europaea L.), Öznur Çeti̇n, Nurengi̇n Mete, Handan Ölmez, Hati̇ce Gülen

Turkish Journal of Agriculture and Forestry

The olive (Olea europaea L.) is widely distributed due to its high adaptability to different environmental conditions. However,in recent years, sudden extreme temperature decreases and frost damage have caused significant yield and quality losses in some regions.This situation has led to the development of varieties with high frost tolerance, suitable for regions where cold damage may occur.It takes many years to develop varieties using classical breeding methods in olives. Therefore, early selection should be made usingbiotechnological methods. Markers about any trait provide a great advantage, especially in plant species with a very long juvenile sterilityperiod, as they allow for a …

Identification And Functional Characterization Of The Icse1 Gene From Ilex Cornuta, Xiaoxi Zhang, Li Zhu, Weiwei Zhang, Feng Xu, Jiabao Ye, Yongling Liao

Turkish Journal of Agriculture and Forestry

Ilex cornuta (I. cornuta) is a traditional Chinese medicine that is rich in various secondary metabolites with pharmacological activities, among which triterpenoid saponins are one of the main active components. Squalene epoxidase (SE) is a key regulatory enzyme in the biosynthesis of triterpenoids. In this study, we isolated a squalene epoxidase (IcSE1) from I. cornuta and analyzed its molecular characteristics and functions. The results indicated that the total length of the IcSE1 sequence was 1942 bp, which includes a 1638 bp open reading frame (ORF) that encodes 545 amino acids. The theoretical isoelectric point (pI) and molecular weight of the …

A Genome-Wide Association Study To Detect Candidate Genes Controlling Iron And Manganese Accumulation In Walnut (Juglans Regia L.), Özge Doğanay, Erdal Orman, Bülent Yağmur, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş

Turkish Journal of Agriculture and Forestry

The walnut is one of the important low-glycemic sources of vegetable protein that benefit human health. Iron (Fe) and Manganese (Mn) are two of the walnut’s important nutritional components. This study aimed to identify single-nucleotide polymorphism (SNP) markers associated with the concentrations of Mn and Fe in walnut kernels and the genetic variation in these concentrations. The population was evaluated for two different years using 154 walnut genotypes and genotyping was performed with 16,473 SNP markers. A genome-wide association study was performed on 154 genotypes. A total of five and 15 SNPs were identified in different walnut genotypes, which were …

Usa V. Daniel Teed

2025 Decisions

USDC for the Western District of Pennsylvania

Robert Archie V. Hamilton Township Municipal Court

2025 Decisions

USDC for the District of New Jersey

Medical Readmissions In Coronary Artery Bypass Graft Patients And The Correlation With Physician Communication, Megan Vandyke

Walden Dissertations and Doctoral Studies

Rising costs in healthcare is a social problem in the United States with medical errors contributing to the rising costs; communication has been identified as a key contributor to medical errors. The purpose of this quantitative study was to further examine if there was a correlation between the independent variable of doctor communication scores and the dependent variable of readmission rates of coronary artery bypass graft surgery patients. This research could contribute to the social problem of rising healthcare costs specifically by identifying variables that may be contributors to costs due to errors. The theoretical framework was Donabedian’s theory of …

Trpv4 Dominates High Shear-Induced Initial Traction Response And Long-Term Relaxation Over Piezo1, Mohanish Chandurkar, Manli Yang, Majid Rostami, Sangyoon J. Han

Michigan Tech Publications

Modulation of endothelial traction is critical for the responses of endothelial cells to fluid shear stress (FSS), which has profound implications for vascular health and atherosclerosis. Previously, we demonstrated that under high FSS, endothelial cells rapidly increase traction forces, followed by relaxation, with traction aligning in the flow direction. In contrast, low shear preconditioning induces a modest short-term increase in traction (min), followed by a secondary long-term (>14 hr) rise, with traction/cells aligning perpendicular to the flow. The upstream mechanosensors driving these responses, however, remain unknown. Here, we sought the roles of Piezo1 and TRPV4 ion channels in shear-induced …

Thrombocytopenia In Sepsis, Alireza Setarehaseman, Robert W. Maitta

Faculty Scholarship

Platelets, traditionally known for their role in hemostasis, have emerged as key players in immune response and inflammation. Sepsis, a life-threatening condition characterized by systemic inflammation, often presents with thrombocytopenia, which at times, can be significant. Platelets contribute to the inflammatory response by interacting with leukocytes, endothelial cells, and the innate immune system. However, excessive platelet activation and consumption can lead to thrombocytopenia and exacerbate the severity of sepsis. Understanding the multifaceted roles of platelets in sepsis is crucial for developing effective therapeutic strategies. Targeting platelet-mediated inflammatory responses and promoting platelet production may offer potential avenues for improving outcomes in …

Promoting Consistency In Phq-9 Depression Screening For Young Adults In An Outpatient Mental Health Clinic., Abena V. Prempeh

Walden Dissertations and Doctoral Studies

This project aimed to improve the consistency of PHQ-9 depression screenings for young adults in an outpatient mental health clinic. Through the implementation of standardized protocols and staff training, the goal was to reduce variability in screening outcomes. The evaluation method of the project involved staff interviews, surveys, and comparing pretest and post-test results to measure staff knowledge and confidence improvements. The results showed that there were significant improvements in staff knowledge and confidence. This project highlights the importance of standardized procedures in improving mental health care for young adults.

The Relationship Between Remote Followers’ Perceptions Of Leader’S Emotional Intelligence And Followers’ Psychological Safety, Gender, And Tenure, Jeanine P. Stroud

Walden Dissertations and Doctoral Studies

This quantitative study explored the relationship between remote workers’ perceptions of their leaders’ emotional intelligence and their self-reported psychological safety, with gender and tenure as moderating variables. Data from 172 remote employees using a cross-sectional online survey revealed that perceived leader emotional intelligence was a significant predictor of psychological safety, both as a composite measure and across its four dimensions of emotional intelligence: self-emotional appraisal, others’ emotional appraisal, regulation of emotion, and use of emotion. Gender moderated the relationship with the combined interaction of worker and leader gender in female leader–female follower dyads. Tenure with the leader did not moderate …

Agile Culture As Experienced By Scrum Masters In The Financial Sector, Andrew John Haigh

Walden Dissertations and Doctoral Studies

There is a high failure rate for software development projects, even those that have adopted an Agile approach, despite the United States spending more than $250 billion yearly on developing 175,000 software projects costing $2,322,000 on average. Scrum masters on software development projects with an Agile approach need to adopt more than just the process and procedures; they need to adopt the Agile culture. The purpose of this general qualitative study was to explore the implementation of the Agile culture experienced by scrum masters in the financial sector. The Scrum software development framework is the most popular variant of the …