Digital Commons Network^™

Mitochondrial Dysfunction Is A Hallmark Of Woody Breast Myopathy In Broiler Chickens, Elizabeth S. Greene, Paula R. Chen, Carrie Walk, Mike Bedford, Sami Dridi

Poultry Science Faculty Publications and Presentations

The woody breast (WB) myopathy poses significant economic and welfare concerns to the poultry industry, however, there is no effective strategy to mitigate this pathology due to its unknown etiology. After showing previously that hypoxia is a key factor in WB progression, we used here various techniques demonstrating dysregulated mitochondria (morphology, biogenesis, tethering, function, and bioenergetics) in WB-affected muscles and in hypoxic myoblasts compared to healthy tissues and normoxic cells, respectively. The increased levels of calcium (Ca2+) in both WB-affected tissues and hypoxic myoblasts suggested that mitochondrial Ca2+ overload is likely a leading cause for mitochondrial dysfunction that merits further …

The Role Of Urinary Microbiome Analysis In The Diagnostic Approach And Management Of Urinary Incontinence: A Systematic Review, Pouyan Shaker, Zohreh Roshani, Ehsan Timajchi, Zahra Sharifi, Sarah Nikzadfar Goli, Behrooz Broumand, Mohammad Ali Shafiee

Student Publications

Urinary incontinence (UI) is a significant global health issue that impacts mainly middle-aged women, severely affecting their quality of life. Emerging research highlights the urinary microbiome's complex role in the etiology and management of UI, with microbial dysbiosis potentially influencing symptom severity and treatment outcomes. This systematic review aimed to evaluate the current evidence on the urinary microbiome's role in diagnosing and managing UI, focusing on variations in microbial composition across UI subtypes. We identified 21 studies, mostly employing 16S rRNA sequencing to characterize urinary microbiota and their associations with various UI subtypes, including urgency urinary incontinence (UUI), overactive bladder …

The Unfolding Story Of Protein Misfolding Causing Alzheimer Disease In Recipients Of Human Pituitary Growth Hormone, Evan G. Graber, Sayed M. Hadi Hosseini, Darrell M. Wilson, Alan D. Rogol

Division of Endocrinology, Diabetes and Metabolic Diseases Faculty Papers

Human growth hormone (hGH) has been in clinical use for children with GH deficiency (GHD) since the late 1950s. The original formulations were considered very safe with few adverse events reported. That changed remarkably in 1985 when the first patients with GHD, who had been treated with cadaveric hGH, were diagnosed with Creutzfeldt-Jakob disease (CJD). Fortunately, that same year a robust supply of recombinant hGH was released to the market whose adverse event profile did not include CJD. Patients who had received National Hormone and Pituitary Program hGH have been continuously followed since 1985. It is clear that prions are …

Development Of An Evidence-Based Program To Increase Burnout Knowledge Among Psychiatric Mental Health Nurse Practitioners In An Inpatient Psychiatric Hospital, Christianah Agunanne

Walden Dissertations and Doctoral Studies

In this staff education project, I addressed burnout prevention among psychiatric mental health nurse practitioners (PMHNPs) in an inpatient psychiatric hospital. Burnout can cause strain on mental health nurses and reduce patient satisfaction, impair quality of care, and increase medical errors. In this project, I developed and applied an evidence-based program (EBP) on burnout for PMHNPs, educating them about the problem and helping identify, avoid, or at least prevent burnout symptoms. I addressed how an EBP staff education program could affect knowledge and recognition of burnout for PMHNPs working in an inpatient psychiatric hospital. The purpose of the project was …

Chimes: February 17, 2025, Calvin University

Chimes

Confusion, apprehension run high among faculty as gravamen decision still up in the air by McKenna Wilkinson, Sarah Sparling & Ethan Meyers

Mayor David LaGrand, Calvin alum, shares his vision for Grand Rapids by McKenna Wilkinson & Sarah Sparling

The future and past of interdisciplinary minors by Elisabeth Stevens

Valentine's Week In A Nutshell by Natasha Jayaputra

"Team One": Women's acrobatics and tumbling makes history with first varsity match by Zach Kern

Late-Night concert sparks excitement for performing at Calvin by Stella Stachowiak

The Lymph Trial: Comparing Microsurgical With Conservative Treatment For Chronic Breast Cancer-Associated Lymphoedema - Study Protocol Of A Pragmatic Randomised International Multicentre Superiority Trial, Elisabeth A Kappos, Justin M Sacks, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Up to one-fifth of breast cancer survivors will develop chronic breast cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard of treatment. However, it is mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) and vascularised lymph node transfer (VLNT) are microsurgical techniques that aim to restore lymphatic drainage. This international randomised trial aims to evaluate advantages of microsurgical interventions plus CDT versus CDT alone for BCRL treatment.

METHODS AND ANALYSIS: The effectiveness of LVA and/or VLNT in combination with CDT, which may be combined with liposuction, versus CDT alone will …

Ndls Communicator: Week Of 02.17.25, Notre Dame Law School

NDLS Communicator

The Latest News

• ND Law Global Human Rights Clinic advocates for human rights before United States International Trade Commission
• ND Law's Black Students Association celebrates Black History Month and the pursuit of justice
• Professor Jorge Barrera-Rojas defends dissertation to earn two doctoral degrees
• Notre Dame Law School's Religious Liberty Clinic secures asylum for Iranian Christian convert facing persecution

Faculty News and Briefs

• Paul Miller was cited in an important dissenting opinion by Justices Gordon, Edelman, and Steward of the High Court of Australia for his work on fiduciary obligations.
• This week, A.J. Bellia will speak on the legal implications of …

Impulsivity Facets And Substance Use Involvement: Insights From Genomic Structural Equation Modeling, Laura Vilar-Ribó, Alexander S Hatoum, Andrew D Grotzinger, Travis T Mallard, 23andme Research Team, Sarah Elson, Pierre Fontanillas, Abraham A Palmer, Daniel E Gustavson, Sandra Sanchez-Roige

2020-Current year OA Pubs

BACKGROUND: Impulsivity is a multidimensional trait associated with substance use disorders (SUDs), but the relationship between distinct impulsivity facets and stages of substance use involvement remains unclear.

METHODS: We used genomic structural equation modeling and genome-wide association studies (

RESULTS: We found that the SU and SUD factors were strongly genetically inter-correlated (

CONCLUSIONS: Our findings show that specific impulsivity facets confer risk for distinct stages of substance use involvement, with potential implications for SUDs prevention and treatment.

Black Box Emoji Fix – A Unicode Sanitization Method For Mitigating Emoji-Based Injection Attacks In Llm Systems, Renee Gagnon

Defensive Publications Series

The rapid adoption of Large Language Models (LLMs) in various applications—from natural language processing and content moderation to cybersecurity—has inadvertently exposed these systems to sophisticated Unicode-based attacks. One such vulnerability involves the exploitation of emojis and invisible Unicode characters to bypass content filters, trigger token explosion attacks, and ultimately compromise system integrity. The Black Box Emoji Fix presents a robust, defensive method designed to sanitize Unicode text inputs and mitigate these emerging security threats. This publication details the innovative approach developed by Renee M. Gagnon, which integrates comprehensive Unicode normalization, grapheme cluster analysis, and multilayer filtering techniques to secure LLM …

How To Stop Employees From Stealing Your Trade Secrets: Shifting The Focus To Prevention And Mitigation, Spencer Rabe

The University of Cincinnati Intellectual Property and Computer Law Journal

No abstract provided.

Analytical Factors Boosting Staff Training In University Libraries In Ekiti State, Nigeria – A Review Of The Literature, Japheth Abdulazeez Yaya Dr, Jerome Idiegbeyan-Ose Phd

Library Philosophy and Practice (e-journal)

This paper examined some factors that would boost staff training in university libraries in Ekiti State, Nigeria. A review research design was adopted. Training has been the integral part of any organization that desired to be productive in its services; therefore, university libraries have been embarking on training and capacity enhancement for their employees so as to boost and promote productivity and overall performance of their workforce. To this end, the following factors could contribute to staff training in any library especially the university libraries that are our focus in this paper: training budget and budget, conducive training environment, effective …

State Boundaries Based On Manifestations Of Social Contract Theory In Indonesia, Novianto Sanjaya, Oemar Moechthar, Isyrofah Amaliyah Achmad, Millah Aldillah Achmad

Imam Ja'afar Al-Sadiq University Journal of Legal Studies

This article aims to analyze the boundaries of legal language Mala in prohibita through the theory of social contract that have been proposed by JJ. Rosseau that the country essentially arises from the existence of contractual relationships between communities to trigger the will and form a system called the state (a unionic pactum). Regarding the concept of social will is one of the things that determine how the birth of mala in SE or mala in prohibitum in Indonesia. The legal language in this case is used to study the extent to which the findings of science in modern language …

Leagal Adaptation Of The Container And Its Delivery Contract In The Field Of Cargo Transportation, Haifaa Mezher Falhi, Shatha Abdul – Jabbar Khandan

Imam Ja'afar Al-Sadiq University Journal of Legal Studies

The study of the legal nature of the container and the contract for its presentation in the field of transporting goods is one of the issues that aroused the interest of jurisprudence, legislation and the judiciary because of the problems and difficulties it reflects, the solution of which requires identifying the party providing the container, the nature of the contract concluded in its regard, and the fact that the container provided by the shipper is called the description of the goods, or it A first-degree packaging means, and the contract concluded in respect of it is often a lease contract …

The Legal Situates For Professors Of Private Universities, Saba Noaman Rasheed

Imam Ja'afar Al-Sadiq University Journal of Legal Studies

Obtaining the rights of the worker has become easier to obtain, even if it is through judicial litigation, and what remains in that is a request that proves that a relationship between the two parties is (a work relationship), which requires in cases of violation to resort to general provisions to interpret the relationship by returning (to the labor and civil laws). And the rules especially in cases such as the employment of holders of postgraduate degrees in colleges that operate according to special, independent systems affiliated with the state in oversight and for private institutions in financing and management, …

The Role Of Criminal Policy In Iraq In Protecting And Improving The Environment, Marwa Hassan Laibi, Israa Saeed Al Saadi

Imam Ja'afar Al-Sadiq University Journal of Legal Studies

The universe forms with all its elements a coherent and parallel unit. Every imbalance in this delicate balance leads to endangering life on the earth. Until the last century, human activities were among the natural factors that bring about slow changes in the surrounding environment. However, the dawn of the industrial revolution, the increase in population, the growth of agricultural and industrial investments, technological progress and the wasteful exploitation of natural resources, all of this caused damage to the environment and posed a danger that cannot be underestimated, in which the balance of the natural and human elements that make …

الحق في الرعاية الصحية وأثره على التنمية المستدامة, عباس قاسم محمد الماجدي

Imam Ja'afar Al-Sadiq University Journal of Legal Studies

The citizen's right to health is not enough to be stipulated in charters and legislation, but more importantly is how to embody this right on the ground and within the local legislation of each country, where the right to health care is emphasized as one of the basic rights, without which a person will not be able to enjoy Other rights: economic, political and social rights. It includes the right to optimum physical and mental health. Since the right to health care is not absolute in itself, The efficiency of its implementation depends on the ability of the administrative, institutional …

The Positive Compatibility Between The Assignment Of The Contract And The Law Of The Contract Comparative Study With The French And English Laws, Zahraa Salman Enad, Jaliel Hasan Al-Saiedy

Imam Ja'afar Al-Sadiq University Journal of Legal Studies

It is known that there are different legal principles that must be respected by the parties to the contract, because they constitute a law of the contract, and are represented in the principle of binding force, and the principle of relative effect, as the contractual obligations arising correctly take the place of the law, where they must be respected by the parties to the contract, not Cancellation or modification except with the consent of the parties, and since the assignment of the contract makes the transferor outside the contractual stage where a third party replaces him in the contractual bond …

Rough Draft Math For Engaged Learning, Liza Bondurant, Amanda Jansen

CoE Publications

Mathematics educators often face the challenge of students disliking mathematics or experiencing a negative relationship with the subject. Intentional teaching practices can be a mechanism to mitigate this challenge; thus, preservice and novice teachers would benefit from opportunities to develop such teaching practices. This research explored the potential of rough draft math (RDM) to support teachers in addressing these issues. RDM is a pedagogical approach where students discuss and share their preliminary mathematical ideas without the fear of being wrong. Teachers welcome rough draft thinking, which gives students explicit opportunities to review their work or thinking. This study examined the …

Sustainable Model For Analyzing The Impact Of Social Media On Customer Buying Behavior: A Case Study, Bshair Alharthi, Mohammed A. Farsi

Sustainable Machine Intelligence Journal

In today's digital landscape, chatbots have become widely used across various applications, particularly in systems that provide intelligent assistance to users. To enhance user experience, these systems are often equipped with chatbots capable of processing user inquiries and delivering accurate, timely responses. This study proposes a structured framework for evaluating the impact of social media on customer buying behavior through a case study focused on selecting the most suitable Online Chatbot Platform (OCP). The selection of an optimal OCP is a complex multi-criteria decision-making (MCDM) problem, involving multiple interdependent and often conflicting factors. One of the key challenges in this …

Does Bank Expansion Reduce Domestic Violence? Causal Evidence From India, Rikhia Bhukta, Chandan Kumar Jha, Rikhia Bhukta, Ashish K. Sedai K. Sedai

Economics Faculty Works

Multiple studies have shown that dowry payments are among the main causes of domestic violence in developing countries. This paper studies the effects of banking expansion on dowry payments and domestic violence in India. Using a fuzzy regression discontinuity design, we present robust evidence that financial inclusion brought about by banking expansion reduces dowry-related deaths and cruelty by husbands. We propose two primary mechanisms underlying this relationship. First, banking expansion enhances the ability of the bride's family to make higher cash payments and more wedding gifts to the groom's family at the time of marriage, often known as dowry. Second, …

The Effect Of Education Policy On Crime: An Intergenerational Perspective, Ulrika Ahrsjö, Costas Meghir, Mårten Palme, Marieke Schnabel

Cowles Foundation Discussion Papers

We study the intergenerational effect of education policy on crime. We use Swedish administrative data that links outcomes across generations with crime records, and we show that the comprehensive school reform, gradually implemented between 1949 and 1962, reduced conviction rates both for the generation directly affected by the reform and for their sons. The reduction in conviction rates occurred in many types of crime. The key mediators of this reduction in child generation are an increase in education and household income and a decrease in crime among their fathers.

Enhancing Learning In The Uae: Exploring Chatgpt As A More Knowledgeable Other (Mko) In Science And Non-Science Courses In The Uae, Nagaletchimee Annamalai, S. Abdellatif, Gaforov Ikboljon Uktamovich, Bilal Mohammed Zakarneh

The Qualitative Report

This study examines the role of ChatGPT as a More Knowledgeable Other (MKO) in educational settings, encompassing both scientific and non-scientific courses. A qualitative case study involved 20 educators from higher education institutions. Data collection was conducted through semi-structured interviews, and the collected data was subsequently analysed using the thematic analysis suggested by Braun and Clarke (2006). The findings emphasize the significance of validating educational resources and maintaining control over their usage to mitigate issues related to plagiarism and uphold academic integrity. ChatGPT serves as an MKO by guiding learners in enhancing their technical writing skills and aiding in information …

Survival Against The Odds: Successful Treatment Of Incomplete Traumatic Hemipelvectomy In A 29-Year-Old Woman Following A Boating Accident, Max Smith, Joseph R. Lewis, Taryn Bolling, Scott Brick, Patrick Leach

Student Publications

Traumatic hemipelvectomy (THP) is a rare, life-threatening injury characterized by the dislocation of the hemipelvis, often resulting from high-energy trauma. It carries a high mortality risk due to severe vascular injuries, with survival contingent on rapid hemorrhage control and a multidisciplinary approach. Limb salvage is rarely achievable due to the extent of the injury and complications such as infection and tissue nonviability. We present a case of incomplete THP in a 29-year-old woman who sustained severe soft tissue, bony, and vascular injuries following a boating accident. On arrival, the patient was in critical condition with a massive hemorrhage, requiring immediate …

Strengthening Legal Frameworks And Patient Safety: A Narrative Review Of Medical And Dental Malpractice In Indonesia, Ghulam Mustafa, Ede Surya Darmawan

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Many cases of medical and dental malpractice in Indonesia are still related to patient safety and healthcare quality. This narrative review aims to identify solutions that can be implemented. The main focus is to compare the incidence of malpractice in clinical medical and dental practice, emphasizing legal implications, coverage, and internal organizational issues. A systematic literature search was conducted through databases such as Pubmed, ScienceDirect, Google Scholar, Springer, Garuda, and other online databases. Articles published no later than 2024. Eleven studies were selected that discussed the problem of malpractice in Indonesia. Independent screening and critical appraisal were carried out to …

Association Of Hyponatremia With Outcomes After Geriatric Trauma: A Systematic Review And Meta-Analysis, Ariana Naaseh, Steven Tohmasi, Carrie Stoll, Chongliang Luo, Lauren H Yaeger, Mark H Hoofnagle, Graham A Colditz, Marguerite W Spruce

2020-Current year OA Pubs

BACKGROUND: Trauma is a major cause of mortality in the elderly population. Hyponatremia is the most common electrolyte imbalance in geriatric patients and has been demonstrated to be a risk factor for altered cognition, low bone density, falls, and death. We systematically and critically reviewed the literature to ascertain the association between hyponatremia and geriatric trauma outcomes.

METHODS: We searched seven databases for articles published from inception to October 2023. Studies included reported on geriatric trauma, hyponatremia, and clinical outcomes. Two investigators independently reviewed 6535 abstracts, 235 full-text articles, and critically appraised each study. Study details, patient characteristics, and outcomes …

Sowing The Seeds Of Confusion To Reap Content Mastery, Rebecca Mcgrail

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Getting Students Excited About Chemistry, Jovita Daraezinwa

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Overcoming Students' Resistance To The Flipped Classroom, Koji Tanno

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Zines: Radical Tools For Empathy And Introspection, Aanya Chugh

Greater Faculties: A Review of Teaching and Learning

No abstract provided.

Freshwater Mussels Of Kansas: Register Of Taxa, Synonyms, And Assumed Misidentifications, Mark E. Eberle

Biological Sciences Faculty Publications

The literature on freshwater mussels (Mollusca: Margaritiferidae and Unionidae) of Kansas includes a collection of names of species and subspecies that makes it difficult for even experienced malacologists to decipher which taxa actually were collected. Compounding this problem is the absence of voucher specimens for some of the studies conducted in the state. This list was compiled to aid those who are conducting research and want to assess their results with reference to the earlier accounts. The alphabetical list of valid taxa, synonyms, and assumed misidentifications of freshwater mussels of Kansas is drawn from the literature and not an examination …