Digital Commons Network^™

Integrating Geo Analysis And Machine Learning For Identifying Transcriptomic Signature Of Ev-A71 Infection, Li Li, Guifang Hu

Journal of Pediatric Infectious Diseases

Objective: To identify a transcriptomic signature associated with EV-A71 infection using peripheral blood mononuclear cells (PBMC) transcriptome profiles from the public dataset GSE135964, which compares samples from subjects with Enterovirus A71 (EV-A71) infection against healthy controls based on bioinformatics and machine learning algorithms, for exploratory biomarker discovery. Methods: The publicly available dataset GSE135964, accessed through the Gene Expression Omnibus (GEO) database WAS analyzed. Differential expression analysis was conducted with a |log2FC| ≥ 0.5 and an adj.P.Val < 0.05 cutoff. The resulting gene set was then visualized through box plots, PCA, volcano plots, and heatmaps. Subsequently, we utilized the random forest algorithm, which quantified gene importance by integrating the mean decrease in both accuracy and the Gini index. This process culminated in the selection of the highest-ranking 10% of genes for subsequent candidacy. Functional characterization of the candidate genes involved Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, alongside the establishment of a protein-protein interaction (PPI) network leveraging the STRING database. Results: Our analysis revealed 438 differentially expressed genes (DEGs), with a marked imbalance towards upregulation (415 genes) compared to downregulation (23 genes). Random forest screening identified 44 candidate genes. PPI analysis identified 23 key genes, and LASSO regression finally pinpointed three feature genes: IFIT5, OASL, and PLSCR1. ROC analysis showed AUC values of 0.964, 0.921, and 0.894 for OASL, PLSCR1, and IFIT5, respectively, indicating a strong association with EV-A71 infection. Enrichment analysis implicated these feature genes in antiviral biological processes, suggesting a core mechanism involving antiviral defense (GO:0051607) to viral RNA binding (GO:0003727). Conclusions: The identified three-gene signature, enriched in antiviral response pathways, provides a theoretical basis for future research into host transcriptomic responses to EV-A71 infection and the RIG-I signaling axis. This transcriptomic signature analysis offers an exploratory resource for understanding EV-A71–associated HFMD.

Late-Onset Cobalamin C Deficiency Associated Atypical Hemolytic Uremic Syndrome – Diagnostic Pitfalls: A Case Report, Martha Stampfli, Sibylle Tschumi, Giacomo Simonetti, Corinne Benchimol, Gabriela Oesch, Alexander Lämmle, Matthias Baumgartner

Journal of Child Science

Introduction: Cobalamin C (cblC) deficiency represents a rare but treatable and potentially underrecognized cause of thrombotic microangiopathy (TMA) in both pediatric and adult populations. It is a multisystem disorder with heterogeneous clinical manifestations. TMA occurs in 10-25% of affected individuals. Case presentation: A ten-year-old girl presented with vomiting and abdominal pain, followed by generalized status epilepticus and hypertensive crisis. Neuroimaging was unremarkable. Laboratory evaluation demonstrated severe renal impairment (creatinine 506 µmol/L), microangiopathic hemolysis and thrombocytopenia. Atypical hemolytic uremic syndrome (aHUS) was suspected and treated with eculizumab and intermittent hemodialysis. Genetic analysis identified biallelic pathogenic variants in the MMACHC gene, confirming …

Development Of The Toileting Habit Profile Questionnaire -2nd Revision; Assessing Sensory-Based Toileting Difficulties, Isabelle Beaudry-Bellefeuille, Eduardo Ramos-Polo

Journal of Child Science

Background: Childhood functional defecation disorders (FDD), including functional constipation and non-retentive fecal incontinence, are classified as disorders of gut–brain interaction and are increasingly recognized as a public health concern. FDD are commonly associated with challenging toileting behaviors and reduced participation in age-appropriate toileting routines, which may contribute to both the onset and maintenance of symptoms. Identifying factors underlying toileting participation difficulties is essential for effective intervention planning. Occupational therapy practitioners have developed expertise in addressing participation challenges in daily activities, including toileting, and in identifying sensory integration issues that may interfere with engagement. Aim: This paper introduces the Toileting Habit …

Field Trials Report 2025: Wa Farming Systems Project (Daw2204-003rtx), Department Of Primary Industries And Regional Development, Western Australia

Farm Systems and Economics research reports

In 2025 the Western Australian Farming Systems Project continued its program of field trials, from Northampton in the north to Wittenoom Hills in the south, to address our project outputs; investigate diversity within farming systems, evaluate changes in sowing opportunities, identify profitable low greenhouse gas emission options and monitor crown rot following diverse crop sequences.

A Comparative Study Of Aging And Cortical Folding In Chimpanzees And Olive Baboons, William D. Hopkins, Angela M. Achorn, Michele M. Mulholland, Elizabeth R. Magden, Steven J. Schapiro, Courtney L, Fults, Jean‐Francois Mangin, Adrien Meguerditchian

Anthropology Faculty Publications

In light of the evidence that nonhuman primates naturally develop Alzheimer's disease neuropathologies, there is a renewed interest in research on the comparative biology of aging, including neurological changes across the age groups in species with diverse lifespans. In this paper, we examined age‐related differences in two measures of cortical folding, mean depth and fold opening, in a sample of chimpanzees (Pan troglodytes) and olive baboons (Papio anubis). We found significant species differences in the slope and pattern of age‐related changes in cortical folding. As predicted, chimpanzees showed negative linear associations between age and mean depth and …

Leader Election System For An Unmanned Ground Vehicle Swarm, Milan Chhetri, Brendan Beas, Paul Levin

Electrical Engineering

This senior project presents the design and implementation of a leader-election system for a leader-follower unmanned ground vehicle (UGV) swarm using embedded control and wireless communication. The objective of the project is to improve the robustness and mission longevity of a multi-agent robotic system by allowing the swarm to dynamically select the most suitable leader during operation. Each UGV is equipped with an ESP32 microcontroller, DWM1000 Ultra-Wideband (UWB) ranging modules, an MPU-6050 inertial measurement unit (IMU), motor drivers, and supporting power electronics to enable communication, sensing, and autonomous control. A battery monitoring subsystem was developed using the ESP32's built-in Analog-to-Digital …

Maximum Power Point Tracker And Dc/Dc Converter, Isabel Aguas, Madeline Steiner, Haley Blouin, Tristan Asquith, Ellijah Garcia

Electrical Engineering

The product is a solar Maximum Power Point Tracker (MPPT) with an integrated DC-DC converter for efficient power extraction from a solar module. The MPPT optimizes solar energy, sourcing power to a 12V battery which is the source of a DC-DC converter operating as a variable voltage output for various applications, capable of providing voltage greater or less than the voltage supplied by the solar module. The DC-DC converter outputs a manually adjustable DC voltage within the range of 5-50V. Both MPPT and the DC-DC converter are functional for standard solar modules with power ratings ranging from 50-400W, open circuit …

Archimedean Spiral Antenna Array With Klopfenstein And Exponential Tapered Balun Feeds, Leo Joseph Alvelais Iv, Paul Obrecht, Naguib Abdulla, Preston Mavady, Collin Fan

Electrical Engineering

This project presents the design, fabrication, and experimental evaluation of a broadband 3x3 Archimedean spiral antenna array tile for 2.8-3.8 GHz. Each element combines a two-arm spiral on Rogers RO4350B, a printed 50 to 150 Ω tapered balun, and a conductive backplane. Klopfenstein and Exponential feed implementations were modeled in Ansys HFSS, generated and tuned with automated scripting, fabricated, and evaluated with calibrated network and anechoic-chamber measurements. The Klopfenstein-fed hardware met the -10 dB input-reflection criterion across the project band. The exponential array provided a broad matched response but reached approximately -8 dB near 2.95 GHz. Measured center-element patterns retained …

Vision-Based Autonomous Tracking Rover, Alejandro Ahumada, Erick Ayala, Jonathan Chavez

Electrical Engineering

AAC Vision designed and constructed a vision-based autonomous tracking rover capable of exploring an indoor environment, avoiding obstacles, generating a two-dimensional LiDAR map, detecting a standard orange basketball, and approaching the target without manual steering. The rover uses a Raspberry Pi 4, an Intel RealSense D435 RGB-D camera, an RPLIDAR C1, four JGB37-520 Hall-encoder motors, dual H-bridge motor drivers, a 12 V battery, and a custom aluminum chassis measuring approximately 8 in by 12 in and weighing 6.7 lb. The final mission emphasized reliable target discovery rather than travel between predetermined points. The software integrates Python, OpenCV, Ultralytics YOLO, RealSense …

Crustal Structure Of The Vøring Plateau And Vøring Spur From Joint Refraction And Reflection Travel-Time Tomography, Anika Nawar Mayeesha

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Crustal architecture of the Vøring Plateau and Vøring Spur in the mid-Norwegian continental margin remains debated because the geophysical data in the area do not uniquely constrain whether the crust is continental, oceanic, or transitional. This study reanalyzes wide-angle ocean-bottom seismometer data from Profile 11-03 across the Vøring passive continental margin using joint travel-time tomography of crustal refractions and Moho reflections. A total of 6,760 first-arrival picks and 542 PmP picks from sixteen instruments were inverted for P-wave velocity and reflector depth. Three starting models were inverted independently to test sensitivity to the initial crustal configuration. The first two used …

Observing System Simulation Experiments To Investigate Impacts Of Deep-Tropospheric Uas Flights On Forecasts, Kenneth Alexander Swan

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Uncrewed aircraft systems have emerged as a promising option to address meteorological gaps in observations in the lower troposphere. With recent advancements, UAS may be able to address gaps aloft in areas that lack coverage from radiosondes and commercial aircraft. UAS have shown the potential to significantly benefit NWP forecasts from profiles in the lowest 2 km AGL, but the impact of UAS profiles to the tropopause has yet to be quantified. Additionally, the impacts of hazardous flying conditions that UAS would encounter need to be addressed to guide future UAS capabilities. To address these questions, we designed an observing …

Usa V. Miguel Rosario

2026 Decisions

USDC for the Middle District of Pennsylvania

Systematic Errors In Judging The Performance Of Others, Michael J. Benson

Psychology ETDs

The well-documented tendency of people to be poor estimators of their relative abilities can be problematic in real life. These errors in are highly asymmetric: the worst performers dramatically overestimate their relative ability, whereas the best performers underestimate theirs (Kruger & Dunning, 1999). There are two possible causes of this misjudgment of relative ability: 1) participants are poor estimators of their own performance, or 2) participants are poor estimators of the comparison group’s performance. Kruger and Dunning (1999) attributed overestimation in the worst performers to the former problem but attributed the underestimation in the best performers to the latter problem. …

Rural Business Development Corporation Annual Report 2025-26, Department Of Primary Industries And Regional Development, Western Australia

Reports

Overview

In this report, the Rural Business Development Corporation is referred to as ‘the Corporation’ or ‘the RBDC’. The RBDC is an independent statutory authority of the Government of Western Australia (WA), established under the Rural Business Development Corporation Act 2000 (Act). The Act preserved and continued the body corporate established by the Rural Adjustment and Finance Corporation Act 1993.

What we do

The RBDC administers approved assistance schemes on behalf of the WA Government for the benefit of rural industry and regional communities. Approved schemes may provide financial assistance by way of loans, grants, or other financial incentives. The …

From Chainsaws To Courtrooms: Corporate Climate Litigation And Deforestation In Brazil, Maria Antonia Tigre, Mariana Barbosa Cirne

Sabin Center for Climate Change Law

Corporate climate litigation has emerged as one of the most dynamic and high profile tools for addressing the private sector’s role in the climate crisis. While much of the scholarship and public debate has centered on cases in the United States and Europe, litigation targeting corporations in the Global South — particularly Brazil — has grown rapidly, both in volume and significance. Brazil now ranks among the world’s top jurisdictions for corporate climate damage claims. These suits have pioneered methods for quantifying climate damages, often from illegal deforestation, and have tested the reach of the civil liability regime in novel …

Social Media Adoption In Urban And Rural Flood Risk Management: Evidence From Nebraska’S 2019 Flood-Affected Regions, Anisha Khandokar

Community and Regional Planning Program: Theses

Flooding is one of the most devastating natural hazards, causing significant economic losses and threatening public safety. While social media has emerged as a powerful tool for disaster communication, its effectiveness in rural flood risk management remains underexplored. This study evaluates the role of social media in disseminating flood-related information and engaging communities during and after 2019 Nebraska floods. This study incorporates SWOT (strengths, weaknesses, opportunities and threats) analysis method to examine how the seven core communication functions were utilized for flood risk management at the state, regional, and local levels. The findings reveal that while state agencies dominated social …

Too Big, Too Soon: Investigating Black Hole Masses In High-Redshift Jwst Agn Using Belmac, Katrina Mcmaster

Theses

The masses of supermassive black holes (SMBHs) in high-redshift quasars are commonly estimated using virial mass estimations calibrated on active galactic nuclei (AGN) in the local universe. However, when applied to new James Webb Space Telescope (JWST) observations at high redshift, these methods often yield SMBH masses that exceed theoretical growth limits, implying the need for heavy black hole seeds or periods of high mass accretion rates, also known as super-Eddington accretion. This tension highlights potential limitations of the virial approach at early cosmic times. This work investigates an alternative method for estimating high-redshift SMBH masses using the Broad Emission …

Butte Reclamation Evaluation System Corrective Action Plans For Reclaimed Sites 2025 Bres Site Specific Corrective Action Plans For Quadrant 2, Butte-Silver Bow Department Of Reclamation And Environmental Services

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Rethinking Preoperative Mrsa/Mssa Screening Through Molecular Triage, Rob E. Carpenter, Greg Whitlock

Human Resource Development Faculty Publications and Presentations

Background: Preoperative screening for methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) is intended to identify patients at increased risk of surgical site infection and guide decolonization and perioperative antimicrobial prophylaxis. However, many molecular assays reduce this decision to a binary positive/ negative result, potentially obscuring clinically important distinctions in organism identity, methicillin resistance attribution, and mupirocin resistance risk. Methods: This structured narrative review organized direct perioperative evidence and indirect mechanistic, implementation, and economic evidence around one question: how MRSA/MSSA screening can move from organism detection to actionable molecular triage. Results: Useful preoperative reporting depends on assigning resistance markers …

Fast Online Inference On Semiparametric Models, Xiaohong Chen, Elie Tamer, Qingsong Yao

Cowles Foundation Discussion Papers

This paper develops a framework for fast online inference on semiparametric models with large sample sizes and possibly many covariates. The computational algorithm itself is the object of statistical study: after a globally consistent warm start in the first phase, the path of averaged online iterates generated in the second phase automatically delivers estimators with optimal convergence rates and valid confidence sets. Both phases require only a single pass over the data stream and are well suited to streaming data or to settings with storage/privacy constraints. For semiparametric monotone index models, the averaged trajectory of the second phase lead to …

The Risk Protection Value Of “Moral Hazard”, Angie Acquatella, Victoria Marone

Cowles Foundation Discussion Papers

Health insurance lowers the out-of-pocket price of healthcare, and it is well-established that this leads to higher utilization of care. This manifestation of “moral hazard” is typ ically viewed as a social cost of insurance. Within a standard model, this paper shows that a consumer’s ability to change her behavior in response to insurance can also play a central role in the ability of insurance to protect her from risk. We provide a theoretical characterization of this channel and quantify its importance empirically. Under stan dard parameterizations and estimates in the literature, we find that insurance-induced healthcare utilization can account …

Data-Driven Characterization Of Counties In The Prison Industrial Complex Using Clustering Analysis, Riley N. Tuccio

Capstone Projects

This project investigates the complex relationship between counties that house prisons in the United States and the rurality associated with them. The central research question explores how both county characteristics, such as variables corresponding to cost of living and demographics of a county, and prison characteristics, such as programming available to inmates and staffing levels, differ across the census-designated rural-urban distinctions. Furthermore, the study examines whether modern data science methods can more accurately define and distinguish these characteristics, providing a nuanced understanding of the Prison Industrial Complex (PIC) and its manifestation across various American communities. The motivation for this research …

Uti, Delirium, And Dementia: A Conceptual Bioinformatics Framework For Clinical Attribution, Rob E. Carpenter, Andrew Krouse

Human Resource Development Faculty Publications and Presentations

Urinary tract infection (UTI) is frequently invoked to explain delirium, confusion, and functional decline in persons with dementia. Yet urine positivity in this population often reflects asymptomatic bacteriuria, colonization, chronic pyuria, contamination, or sampling noise rather than clinically attributable infection. For biomedical informatics and computational diagnostics readers, this narrative review contributes an integrative conceptual bioinformatics framework for probabilistic clinical attribution of suspected UTI in dementia under uncertainty. We formalizes the attribution problem by distinguishing organism detection from a clinically plausible infection-related contribution to neurocognitive decline. The framework integrates clinical, laboratory, biological, and longitudinal data to clarify whether urinary findings are …

Department Of Justice Office On Violence Against Women Campus Program Grant: Cwru Impact Evaluation, Hannah Regan, Emma Getz, Megan Gergen

Mather Center Research Briefs

This brief reviews the goals of the Mather Center's DOJ Campus Program grant and evaluates their impact on our campus. It also outlines how we intend to sustain this work following the conclusion of the grant's funding period.

The Impact Of Emergency Nurse Experience On Triage Accuracy During High-Volume Emergency Department Shifts, Grace Littlefield Rn, Mia Cianchette Rn, Benjamin Drummey Rn, Charles Stever Rn

Nurse Residency

PICOT Question: In adult emergency department patients, how does assigning an experienced emergency room nurse to the triage role compared to assigning a less experienced nurse improve triage accuracy rates during high-volume shifts?

Needs Assessment For Evaluation Competencies Among Extension And Outreach Professionals, Mariah K. Awan, Hui-Hui Wang, Rama Radhakrishna

Journal of Human Sciences and Extension

We conducted an extensive literature review to develop an assessment tool with both quantitative and qualitative items that can be used to conduct a statewide needs assessment of professional development needs in program evaluation for Extension educators and similar non-profit organizations. This tool can be used to identify priority topics for evaluating professional development trainings and materials. It can be easily distributed via Qualtrics. The results of the literature review and the needs assessment survey instrument are shared.

Evaluating The Impact Of A Community-Based Prenatal Education Program On Maternal Knowledge And Intentions In Utah, Aaron T. Hunt, Jenna Dyckman, Kaylee Cox

Journal of Human Sciences and Extension

Maternal and infant health in the U.S. has worsened, with rising rates of maternal mortality, gestational diabetes, postpartum depression, and infant mortality. Prenatal education is a proven strategy to improve outcomes, yet many expecting parents rely on unvetted information or lack access to reliable resources. To address this gap, a pilot prenatal education program was implemented through Utah State University Extension to improve knowledge, attitudes, and intentions related to breastfeeding, nutrition, mental health, and other key topics. The program consisted of 3 1-hour, evidence-based workshops incorporating lectures and interactive activities. A retrospective pre-post survey was completed by 28 pregnant participants …

Culturally Responsive Evaluation In Extension Programs For Indigenous Youth, Sara M. Tomis, J.C. Bunch, Amy Harder, T. Grady Roberts

Journal of Human Sciences and Extension

Indigenous communities, deserving and in need of salient Extension services, experience disparity in programming and culturally responsive evaluation because of historic and current social and financial barriers. An exploration of culturally responsive evaluation practices in Extension programs serving Indigenous youth audiences is warranted to identify areas for improvement. A focus group of Extension professionals was conducted to investigate evaluation practice within a federally funded Extension program. Findings indicated that Extension professionals were committed to operating and evaluating in ways that respected Indigenous culture, but improvements in culturally responsive practice are needed among both university and federal partners.

Made In America, Hidden By Ai: Ai Shopping Chatbots Reveal How Amazon And Walmart Hurt American Manufacturers And Deceive Shoppers, Erie Meyer, Zachary Harris

Center for Law and the Economy

This article investigates the capabilities of two AI shopping agents — Alexa for Shopping and Sparky, operated by Amazon and Walmart respectively — to identify country of origin for products on their respective platforms and flag potential “Made in USA” misrepresentations — where products with “Made in USA” in their title or listing have another country or “imported” listed as their country of origin. This article finds that (1) Amazon and Walmart have the technical capability to detect and flag “Made in USA” fraud; (2) “Made in USA” fraud appears to be common on both Amazon and Walmart; (3) Amazon …

Building Resilient And Sustainable Built Environments Through Climate Adaptation, Digital Innovation, And Infrastructure Governance, Mohammed Ali Berawi, Mustika Sari, Perdana Miraj

CSID Journal of Infrastructure Development

The built environment has become one of the most important arenas for responding to climate change, resource pressure, and rapid urban transformation. Cities, infrastructure networks, buildings, and construction projects are no longer expected only to provide physical services. They are also expected to reduce environmental impact, protect communities from disruption, support economic activity, and remain useful under uncertain future conditions. This expectation places resilience and sustainability at the center of infrastructure development.

Resilience refers to the capacity of built systems to anticipate shocks, absorb pressure, recover from damage, and continue functioning. Sustainability asks whether those systems can do so while …