Digital Commons Network^™

Dietary Fat Intake And Its Influence On The Association Between Liver Fat And Brain Choline Metabolism In Young Saudi Women, Halima S. Hawesa, Mansour E. Shanawani, Haya A. Alshegri, Mahasin G. Hassan, Amal I. Alorainy, Nouf A. Alroqaiba, Shanoo G. A. Sheikh

Saudi Medical Journal

Objective: Fat-rich nutrition may influence the neurochemical consequences of hepatic lipid accumulation. This study examined whether percent energy from fat modifies the association between liver fat and the brain (Cho/Cr) ratio in healthy young women. Methods: A total of 109 healthy Saudi women aged 18–25 years underwent brain magnetic resonance spectroscopy (¹H-MRS) to quantify Cho/Cr ratios. Liver fat was estimated using MRI-based proton density fat fraction (PDFF), and lipid intake was assessed using a validated food frequency questionnaire. Multivariable regression models tested the interaction between liver fat and fat-derived energy intake, followed by simple slopes analysis, regression …

Urinary Incontinence's Prevalence, Risk Factors, And Quality Of Life Impact On Working Women In Saudi Arabia, Ahmed Mansor, Hatim Tagalsir Osman Ali, Maha Ali, Arwa Abd Al Salam Ashry, Ghala Abdullah Alharbi, Khalid Albasheer, Omer Munder, Isam Mohamed Babbiker Ahmed

Saudi Medical Journal

Background: This study aimed to investigate the prevalence and severity of Urinary incontinence (UI) among working women in Saudi Arabia (SA), identify the associated demographic, lifestyle, medical, and obstetric risk factors, and assess its effect on quality of life and work productivity. The UI is a common underreported condition that affects women's daily functioning and life quality, particularly in the workplace. Methods: During 2025, 390 working women in SA who were at least 18 years old and from various work sectors participated in a descriptive cross-sectional survey. Data were gathered using a validated, structured questionnaire; statistical analysis was carried out …

Emerging Strategies For Cardio-Renal Protection Beyond Raas Blockade: Emphasis On Non-Diabetic Ckd And Resistant Hypertension, Fahad S. Alrashidi

Saudi Medical Journal

Non-diabetic chronic kidney disease (ND-CKD) complicated by resistant hypertension remains a high-risk phenotype even when renin–angiotensin system blockade is optimized. This review synthesizes contemporary evidence for cardio-renal protection beyond traditional renin-angiotensin-aldosterone system inhibition (RAASi), with emphasis on mechanisms, clinical trial data, and pragmatic sequencing. Sodium–glucose cotransporter 2 inhibitors provide hemodynamic and tubular benefits that translate into renal and heart failure risk reduction in many patients with ND-CKD. Non-steroidal mineralocorticoid receptor antagonism (MRA) like finerenone targets inflammatory and fibrotic signaling and may add incremental benefit when potassium is proactively managed. The GLP-1 receptor agonists offer cardiometabolic advantages with emerging kidney signals, …

The Use Of Platelet-Rich Plasma For De Quervain's Tenosynovitis: A Systematic Review With Limited Meta-Analysis, Abdullah W. Abumadian, Mohanad I. Binibrahim, Abdurrahman H. Sultan, Mohammed A. Addas, Hattan Y. Bamagaus, Sultan K. Alhaddad, Motasem O. Bamabad, Bayan A. Ghalimah

Saudi Medical Journal

Introduction: De Quervain's tenosynovitis (DQT) is a painful wrist condition that impairs daily activities. Corticosteroid (CS) injections are commonly used for symptom relief, but their effects may diminish over time. Platelet-rich plasma (PRP) has emerged as a regenerative alternative that promotes tissue healing rather than merely suppressing inflammation. This systematic review and limited meta-analysis compare the efficacy and safety of PRP versus CS injections in DQT. A limited meta-analysis was chosen due to the high heterogeneity between studies (I² = 98.7%). Methodology: A comprehensive literature search identified six studies comparing PRP and CS injections. Pain and functional outcomes …

Clinical Outcomes Of Decompression Versus Decompression With Instrumented Fusion For Lumbar Spinal Stenosis Secondary To Degenerative Spondylolisthesis: A Systematic Review And Meta-Analysis, Lama N. Alqahtani, Ahmed K. Alzahrani, Razan A. Almutairi, Abdulaziz M. Salah, Shahad F. Khan, Mohammad G. Sindi, Khalid E. Fassi, Abdulrahman M. Alshami, Ibrahim A. Hakami

Saudi Medical Journal

Objective: To compare decompression alone with decompression with fusion in patients with degenerative lumbar spondylolisthesis. Methods: PubMed, Google Scholar, Ovid, and Web of Science databases were searched up to March 2025 for randomized controlled trials (RCTs). The primary outcomes were the Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) scores. The secondary outcomes included operative time, length of hospital stay, intraoperative blood loss, reoperation, complications, and cost. Pooled analysis was performed using a random-effects model in Review Manager following Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020. The quality of included randomized trials was evaluated using the …

Effects Of Maternal Vitamin D Supplementation During Pregnancy And Lactation On Immune Development In Offspring: A Systematic Review, Kurnia Maidarmi Handayani, Ghaniyyatul Khudri, Laura Zeffira, Widia Sari

Chulalongkorn Medical Journal

Background: Vitamin D, a fat-soluble prohormone, is essential for skeletal health and plays a key role in immune regulation. Deficiency is common among pregnant and lactating women, raising concerns as fetal and neonatal vitamin D status relies entirely on maternal stores. Insufficiency during these periods is linked to preterm birth, low birth weight, and immune-mediated disorders. This review examines the effects of maternal vitamin D supplementation on the immune development of offspring.

Methods: A systematic review was conducted in accordance with PRISMA guidelines and registered in PROSPERO (CRD420251117397). Experimental rodent studies published between 2019 and 2022 that investigated maternal vitamin …

Skip Segment Hirschsprung's Disease: Report Of A Rare Case And Literature Review, Nimmita Srisan, Paisarn Vejchapipat, Natcha Wanpiyarat

Chulalongkorn Medical Journal

We present an unusual case of skip segment Hirschsprung’s disease which was initially diagnosed with total colonic aganglionosis. A term male newborn presented with distal intestinal obstruction underwent exploratory laparotomy at three days old after ultrasound-guided contrast enema. Intra-operative frozen section of the full-thickness biopsies of each part of the colon and terminal ileum reported no ganglion cells, so we performed double-end ileostomy. Although all the final pathology reports confirmed no ganglion cells similar to the frozen sections, we were curious about the problematic bowel because of preoperative imaging (at the age of 30 months) which showed dilated transverse colon. …

Effectiveness And Implementation Of The Shield Integrated Multi-Level Model To Reduce Adolescent Depression And Internet Addiction: A Cluster Randomized Waitlist-Controlled Trial In Wangchin District, Phrae Province, Seubtrakul Tantalanukul, Amornpan Samorn

Chulalongkorn Medical Journal

Background: Adolescent depression and internet addiction represent significant comorbid mental health challenges in rural Thailand, where access to evidence-based interventions remains limited. Traditional single-modality approaches often fail to address the complex interplay between individual, family, and systemic factors contributing to these conditions.

Objectives: To evaluate the effectiveness and implementation outcomes of the SHIELD (Screening & Surveillance, Health Literacy Enhancement, Internet Wellness Program, Empowering Families, Linkage to Care, Data-driven Monitoring) integrated multi-level intervention for reducing depression and internet addiction among at-risk adolescents in rural Thailand.

Methods: A cluster randomized waitlist-controlled trial was conducted across eight secondary schools in Wangchin District, Phrae …

Empowering Tomorrow’S Eco-Leaders: The Role Of Student-Led Recycling And Energy Conservation Initiatives In Fostering Environmental Sustainability In Educational Institutions, Angel Christian S. Arisga, Constantino G. Medilo Jr.

Journal of Educational Research and Practice

Environmental sustainability is now a growing priority in educational institutions as global environmental challenges continue to intensify. This paper studies the role of student-led recycling and energy conservation initiatives in promoting eco-friendly practices and developing environmental accountability among learners. Drawing on existing literature, the study illustrates how active student participation in waste management programs, recycling campaigns, renewable energy implementation, and energy audits contributes to reduced waste generation, lower energy consumption, and decreased greenhouse gas emissions in school settings. Apart from environmental outcomes, these projects foster essential competencies such as leadership, collaboration, problem-solving, and environmental awareness, positioning students as agents of …

Bridging The Gap Between Research And Practice In Schools, Giorgio Ostinelli

Journal of Educational Research and Practice

This case study examined how a group of Swiss primary school teachers collaborated with a school improvement advisor/researcher (SIA); it is now part of a larger project that uses a design-based methodology. The SIA is a rising entity in the educational landscape and serves as a state-mandated coach who bridges the gap between universities and schools. The SIA embodies the characteristics of both an educational researcher and a school advisor/coach. The SIA experience was created and designed using a frame–object, a valuable tool for collaboratively building professional development experiences with teachers and coaches. Understanding by Design served as the frame–object …

Francis Bacon As Philosopher Of Leadership: The Essays As Manual For Values-Based Leaders, Matthew Sharpe

The Journal of Values-Based Leadership

This essay presents the case for Francis Bacon as what we would today term a leadership theorist avant la letter, focusing on the development of the character of leaders, faced with all the pressures of their role.  We aim to show Bacon's leadership theory at once anticipates without directly embodying contemporary leadership theories (in part 1): not only presenting a robust moral vision for leadership, as serving the public good (part 2), but differentiating characteristic kinds of “followers,” with their strengths, weaknesses, and characteristic vices, and realistically addressing how to best lead them (Part 3); and providing ten "how …

Learning Values-Based Leadership Through Practice, Jenny Guan

The Journal of Values-Based Leadership

This essay explores how values-based leadership can be developed through leadership practice in real-world contexts. Drawing on a Servant Leadership book project involving global contributors, it adopts the Values Clarity Model™ as a reflective lens and uses a practice-based approach informed by observation, imitation, and reflection to examine how leadership values are enacted in authentic settings. By analyzing the project in relation to what I learned in the Principles of Business Leadership course at business school, this essay reflects on how leadership values are understood, practiced, and internalized in real-world settings.

This reflection suggests that values-based leadership is not formed …

Beyond The Romance Of Leadership: Shackleton, Self-Inflicted Crisis, And The Values Of Recovery, Carl Lee Tolbert

The Journal of Values-Based Leadership

Two men answered to the name Ernest Shackleton. One belonged to the ice, where he was pioneering, inspirational, and heroic. The other belonged to dry land, where he was restless, indebted, and unfulfilled (Smith, 2014). The 1914 to 1916 Endurance expedition has become the most celebrated leadership case study of the past century, a status the 2022 discovery of the ship's preserved wreck has only hardened. Public and scholarly sentiment runs overwhelmingly positive. This article reads that sentiment as a late expression of what Meindl and colleagues named the Romance of Leadership, the disposition to attribute outcomes to dramatic individual …

Sustaining Purpose In Organizations: Leadership Insights From The Psalms, Hershey H. Friedman, Xianfang Zeng

The Journal of Values-Based Leadership

This conceptual paper examines how the Book of Psalms offers an integrative moral framework that enriches contemporary purpose-driven leadership theory. Although modern management scholarship increasingly emphasizes purpose, stakeholder orientation, and meaningful work, it often focuses on strategic articulation rather than the ethical and relational practices that sustain purpose over time. Drawing on selected Psalms as a historically influential corpus of leadership reflection, this study identifies key leadership principles and situates them within established management literature. Purpose-driven leadership rooted in ancient values builds psychologically safe environments. In these spaces, employees view their work as a meaningful calling instead of a simple …

Irish-Americans Audie Murphy And William Donovan: A Celebrity And A Statesman, Ritch Eich

The Journal of Values-Based Leadership

In the long annals of Irish history, many leaders have distinguished themselves as warriors in battle or as civilian heroes, or both. Lieutenant Colonel Robert Blain “Paddy” Mayne, a founding member of the Special Air Service and a highly decorated World War II British Army officer from Northern Ireland, is one. Monsignor Hugh O’Flaherty, an Irish Catholic priest whose rescue network helped over 6,500, escaped Allied POWs, Jews, and other fugitives at risk of Nazi persecution evade capture by the Germans during World War II, is another.1 But, not all heroes of Irish descent are remembered equally. Take, for example, …

Moral Identity, Joseph P. Hester

The Journal of Values-Based Leadership

Foundationally, our communal awareness offers a complexity of meaning, but don’t be deterred, it also provides an avenue for understanding ethics, suggesting a definition of “humanity” as “community.”

The Character Fractal: A Theory Of Virtue Replication In Organizations, Kevin Davis, Scott Kozlak, Matthew M. Orlowsky, David Levy

The Journal of Values-Based Leadership

Organizational ethics has long been treated as an individual problem requiring individual solutions: the right traits, the right training, the right people in the right roles. This paper argues that framing is fundamentally insufficient. While character and virtue ultimately reside in persons, character development within organizations emerges through recursive ethical interactions shaped by incentives, narratives, feedback loops, and habituation structures cultivated by systems leaders. It replicates, or fails to, across every scale of human interaction, from the unobserved micro-decision of a single employee to the macro-level architecture of executive leadership. Drawing on Mandelbrot's fractal geometry, Lorenz's chaos theory, Kauffman's complexity …

Summer/Fall 2026

The Journal of Values-Based Leadership

No abstract provided.

State And Federal Poster Requirements, Garland Gentry Dds

Virginia Dental Journal

No abstract provided.

Are We Fit To Sit?, Jill Moore

Virginia Dental Journal

No abstract provided.

Third Emporia Mom Makes Music, Jamie Neal

Virginia Dental Journal

No abstract provided.

Physical Safety From Violence In The Dental Practice, Kathleen Roman

Virginia Dental Journal

No abstract provided.

2011 Virginia State Elections Report, Chuck Duvall, Denny Gallagher, Tripp Perrin

Virginia Dental Journal

No abstract provided.

Letters To The Editor

Virginia Dental Journal

No abstract provided.

Trustee's Corner, Charles H. Norman Iii, Dds

Virginia Dental Journal

No abstract provided.

Va Dent J January, February And March 2012

Virginia Dental Journal

No abstract provided.

The Protective Potential Of Intestinal Bifidobacterium-Derived Extracellular Vesicles With Unique Lipid Composition Against Blue Light-Induced Damage In Retinal Cells, Wei-Hsuan Hsu, Pin-Hsuan Su, Hao-Yuan Chien, Tzu-Ming Pan, Bao-Hong Lee

Journal of Food and Drug Analysis

Bifidobacterium longum is a probiotic that resides in the intestine, and extracellular vesicles (EVs) released by microorganisms have garnered attention in recent years for their role in regulating host health. This study found that triacylglycerol, cholesteryl esters, and free fatty acid (18:0 and 16:0) are primarily composed of lipids in B. longum-derived EVs by lipidomics assay. Such lipid composition facilitates the entry of EVs into ARPE-19 cells and protects the cells from oxidative death induced by blue light exposure. Transcriptomic analysis revealed that treatment with B. longum-derived EVs can regulate phosphoinositide 3-kinase and mTOR, thereby enhancing the survival …

Applications Of Nuclear Magnetic Resonance Spectroscopy In Pediatric Clinical Metabolomics: From Research To Future Perspectives, Chieh-Ni Kuo, Meng-Han Chiang, Hsien-Ju Lee, Yu-Ying Yu, Eric Yi-Liang Shen, Chih-Yung Chiu

Journal of Food and Drug Analysis

Metabolomics studies small-molecule metabolites to provide insights into health and disease, supporting early diagnosis and personalized medicine. Advances in mass spectrometry and nuclear magnetic resonance (NMR) have expanded its use in metabolic, cancer, and cardiovascular diseases. In pediatrics, high-resolution NMR metabolomics has been instrumental in identifying age-related metabolic changes during early childhood and their associations with growth, nutrition, and disease risk. However, a comprehensive review of its clinical applications and future potential remains limited. This review highlights how utilizing specific NMR pulse sequences, such as CPMG and NOESY, allows for precise and non-destructive metabolic profiling of diverse biofluids, supported by …

The Evolution Of Desi-Msi: A Comprehensive Look At Preprocessing And Quantification Strategies For Metabolomics, Cheng-Hung Yang, Hung-Yao Ho, Chen-Yu Chang, Mei-Ling Cheng

Journal of Food and Drug Analysis

Mass spectrometry imaging (MSI) has become an indispensable tool in metabolomics for visualizing the spatial distribution of biomolecules within tissues. Due to its direct, ambient analysis capability, desorption electrospray ionization (DESI-MSI) has evolved from a rapid screening tool into a precise and reliable quantitative platform. We delve into its technical principles and particularly review the criticality of sample preprocessing, highlighting the paradigm shift from a "no-preprocessing" approach to one of "optimized preprocessing." The paper details how factors like sample preservation, choice of embedding agents, washing, drying, and on-tissue chemical derivatization all impact data quality. We also discuss how the addition …

Metabolomics Of Per- And Polyfluoroalkyl Substances (Pfas) Exposure: Advances In Lc-Ms Technology And Applications, Yu-Meng Wang, Pei-Chen Lin, Yu-Da Zheng, Pin-Shiuan Wu, Kuo-Tai Hua, Sung-Fang Chen

Journal of Food and Drug Analysis

Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic chemicals known for their high stability and bioaccumulation potential, leading to their widespread presence in the environment and human tissues. Exposure to PFAS has been associated with significant health concerns, including neurotoxicity, hepatotoxicity, and metabolic disturbances. Liquid chromatography–mass spectrometry (LC-MS) based metabolomics has emerged as a powerful and central tool for PFAS research, enabling the comprehensive analysis of metabolic changes induced by exposure. This review provides a critical summary of the applications of LC-MS metabolomics in both clinical studies and various experimental models, including in vivo models (mice) and in …