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Subcortical Correlates Of Consciousness With Human Single Neuron Recordings, Michael Pereira, Nathan Faivre, Fosco Bernasconi, Nicholas Brandmeir, Jacob E Suffridge, Kaylee Tran, Shuo Wang, Victor Finomore, Peter Konrad, Ali Rezai, Olaf Blanke May 2025

Subcortical Correlates Of Consciousness With Human Single Neuron Recordings, Michael Pereira, Nathan Faivre, Fosco Bernasconi, Nicholas Brandmeir, Jacob E Suffridge, Kaylee Tran, Shuo Wang, Victor Finomore, Peter Konrad, Ali Rezai, Olaf Blanke

2020-Current year OA Pubs

Subcortical brain structures such as the subthalamic nucleus or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness remains unclear, due to the inherent difficulties of recording subcortical neuronal activity in humans. Here, we asked neurological patients undergoing surgery for deep brain stimulation to detect weak vibrotactile stimuli applied on their hand while recording single neuron activity from the tip of a microelectrode. We isolated putative single neurons in the subthalamic nucleus and thalamus. A significant proportion of neurons modulated their activity while participants were expecting a stimulus. We found that the firing …


Current Paradigm And Futuristic Vision On New-Onset Diabetes And Pancreatic Cancer Research, Russell Moreland Iii, Abigail Arredondo, Anupam Dhasmana, Swati Dhasmana, Shabia Shabir, Asfia Siddiqua, Bonny Bannerjee, Murali Yallapu, Stephen Behrman, Subhash Chauhan, Sheema Khan May 2025

Current Paradigm And Futuristic Vision On New-Onset Diabetes And Pancreatic Cancer Research, Russell Moreland Iii, Abigail Arredondo, Anupam Dhasmana, Swati Dhasmana, Shabia Shabir, Asfia Siddiqua, Bonny Bannerjee, Murali Yallapu, Stephen Behrman, Subhash Chauhan, Sheema Khan

School of Medicine Publications

New-onset diabetes (NOD) has emerged as a potential early indicator of pancreatic cancer (PC), necessitating a refined clinical approach for risk assessment and early detection. This study discusses critical gaps in understanding the NOD-PC relationship and proposes a multifaceted approach to enhance early detection and risk assessment. We present a comprehensive clinical workflow for evaluating NOD patients, incorporating biomarker discovery, genetic screening, and AI-driven imaging to improve PC risk stratification. While existing models consider metabolic factors, they often overlook germline genetic predispositions that may influence disease development. We propose integrating germline genetic testing to identify individuals carrying pathogenic variants in …


Integrative Computational Modeling Of Distinct Binding Mechanisms For Broadly Neutralizing Antibodies Targeting Sars-Cov-2 Spike Omicron Variants: Balance Of Evolutionary And Dynamic Adaptability In Shaping Molecular Determinants Of Immune Escape, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker May 2025

Integrative Computational Modeling Of Distinct Binding Mechanisms For Broadly Neutralizing Antibodies Targeting Sars-Cov-2 Spike Omicron Variants: Balance Of Evolutionary And Dynamic Adaptability In Shaping Molecular Determinants Of Immune Escape, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this study, we conducted a comprehensive analysis of the interactions between the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and four neutralizing antibodies—S309, S304, CYFN1006, and VIR-7229. Using integrative computational modeling that combined all-atom molecular dynamics (MD) simulations, mutational scanning, and MM-GBSA binding free energy calculations, we elucidated the structural, energetic, and dynamic determinants of antibody binding. Our findings reveal distinct dynamic binding mechanisms and evolutionary adaptation driving the broad neutralization effect of these antibodies. We show that S309 targets conserved residues near the ACE2 interface, leveraging synergistic van der Waals and electrostatic interactions, while S304 focuses on …


It Is Not Clear How Well Physical Activity Promotion Materials Are Understood: Findings From A Rapid Literature Review, Jafra D. Thomas, Jasmine C. Wong, Regina F. Hockert, Yi Sheng Wu, Winston Kennedy May 2025

It Is Not Clear How Well Physical Activity Promotion Materials Are Understood: Findings From A Rapid Literature Review, Jafra D. Thomas, Jasmine C. Wong, Regina F. Hockert, Yi Sheng Wu, Winston Kennedy

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 6, 2025. Efforts to promote physical activity and other health-related behaviors are more effective when resource materials are understood by a wide and diverse audience. Before our lab’s previous investigations (Thomas et al., 2024), only one study seemed to use the cloze procedure to directly test the comprehension (i.e., readability) of physical activity promotion material (Cardinal & Seidler, 1995). Thus, this rapid literature review sought to (a) determine the extent the cloze procedure has been used to study physical activity promotion material comprehension in lay adults and (b) collate …


Valve-In-Valve-In-Valve Transcatheter Aortic Valve Replacement In Practice: Largest Single Center Experience, David Rayan Do, Suhail Allaqaband Md, M Fuad Jan Mbbs, Md, Eric Weiss Md, John Crouch Md, Renuka Jain Md, Tanvir Bajwa Md May 2025

Valve-In-Valve-In-Valve Transcatheter Aortic Valve Replacement In Practice: Largest Single Center Experience, David Rayan Do, Suhail Allaqaband Md, M Fuad Jan Mbbs, Md, Eric Weiss Md, John Crouch Md, Renuka Jain Md, Tanvir Bajwa Md

Scientific Day

No abstract provided.


[2025 Honorable Mention] Ice: Trauma, And The War On Immigrant Families, Brittney M. Williams May 2025

[2025 Honorable Mention] Ice: Trauma, And The War On Immigrant Families, Brittney M. Williams

Ethnic Studies Research Paper Award

This paper exposes how immigration enforcement under the Trump administration’s second term has crossed the line from policy to persecution. ICE is operating like a secret police force, using fear tactics and legal loopholes to tear families apart without cause or due process. The impact is not theoretical. It is real, measurable, and devastating. Children are being taken from schools. Parents are disappearing without explanation. Communities are being pushed into silence and survival mode. This paper focuses on the trauma being inflicted, especially on immigrant youth, and the way outdated laws like the Alien Enemies Act are being twisted to …


The Tax Adviser, Volume 14, Number 5, May 1983, American Institute Of Certified Public Accountants May 2025

The Tax Adviser, Volume 14, Number 5, May 1983, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.


Subject Index 12 Months Ended April 1983, American Institute Of Certified Public Accountants May 2025

Subject Index 12 Months Ended April 1983, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.


Thumbtax, Lynne E. Faigen May 2025

Thumbtax, Lynne E. Faigen

Tax Adviser

No abstract provided.


Washington Report: Employment Taxes And The 100% Penalty, Larry G. Westfall May 2025

Washington Report: Employment Taxes And The 100% Penalty, Larry G. Westfall

Tax Adviser

No abstract provided.


Tax Clinic, Stuart R. Josephs May 2025

Tax Clinic, Stuart R. Josephs

Tax Adviser

No abstract provided.


Subchapter S Revision Act Of 1982 (Part Ii), Lorence L. Bravenec May 2025

Subchapter S Revision Act Of 1982 (Part Ii), Lorence L. Bravenec

Tax Adviser

No abstract provided.


Significant Recent Developments Concerning Estate Planning (Part Ii), Byrle M. Abbin, David K. Carlson May 2025

Significant Recent Developments Concerning Estate Planning (Part Ii), Byrle M. Abbin, David K. Carlson

Tax Adviser

No abstract provided.


Professional Corporations And The Affiliated Service Group, Stephen M. Howard May 2025

Professional Corporations And The Affiliated Service Group, Stephen M. Howard

Tax Adviser

No abstract provided.


State Legislatures And Trans* Genocide (?) In The United States, Shannon Fyfe May 2025

State Legislatures And Trans* Genocide (?) In The United States, Shannon Fyfe

Tennessee Journal of Race, Gender, & Social Justice

No abstract provided.


Severe Pulmonary Hemorrhage In A 36-Week Newborn: A Case Report Of Intractable Respiratory Distress, Phillip Osak Ba, Alexandra Wilson Md May 2025

Severe Pulmonary Hemorrhage In A 36-Week Newborn: A Case Report Of Intractable Respiratory Distress, Phillip Osak Ba, Alexandra Wilson Md

Scientific Day

No abstract provided.


Acute Necrotizing Hypertriglyceridemia-Induced Pancreatitis, John Stevenson Do, Mph, Meklit Hunde Md, Medjine Jarbath Md, Ethan Morgan Do May 2025

Acute Necrotizing Hypertriglyceridemia-Induced Pancreatitis, John Stevenson Do, Mph, Meklit Hunde Md, Medjine Jarbath Md, Ethan Morgan Do

Scientific Day

No abstract provided.


Iterative Process For Improving Compliance With Synoptic Operative Reports In A Large Healthcare System, Mary Brandt Md, Areej Sami Md, Nicole Zaremba Md, Facs, Geoffrey Bellini Md, Facs, Nikolaos Dallas Md, Mba, Facs, Fsso, Ameer Gomberawalla Md, Facs, Carol Huibregtse Msn, Rn May 2025

Iterative Process For Improving Compliance With Synoptic Operative Reports In A Large Healthcare System, Mary Brandt Md, Areej Sami Md, Nicole Zaremba Md, Facs, Geoffrey Bellini Md, Facs, Nikolaos Dallas Md, Mba, Facs, Fsso, Ameer Gomberawalla Md, Facs, Carol Huibregtse Msn, Rn

Scientific Day

No abstract provided.


Table Of Contents & Masthead, Jacqueline Kessel May 2025

Table Of Contents & Masthead, Jacqueline Kessel

Pepperdine Law Review

No abstract provided.


Polyrelativity, Frederic Gilles Sourgens May 2025

Polyrelativity, Frederic Gilles Sourgens

Pepperdine Law Review

Energy transition has a governance problem. And much of the literature fails to address this problem. That is, it discusses who should make energy transition decisions (the President, Congress, state governments, etc.). But this perspective misses the core substantive problem: how should we share the benefits and burdens of transition? Without answering this energy transition “how” question, any answer to “who” risks appearing as arbitrary decision-making. In this Article, I am the first to submit that we can solve this “how” question using the property-law doctrine of correlative rights. Energy-transition governance is what political economists call “polycentric.” It requires different …


The Tax Adviser, Volume 14, Number 4, April 1983, American Institute Of Certified Public Accountants May 2025

The Tax Adviser, Volume 14, Number 4, April 1983, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.


Thumbtax, Lynne E. Faigen May 2025

Thumbtax, Lynne E. Faigen

Tax Adviser

No abstract provided.


Washington Report: Aicpa Comments On Modified Proposed Circular 230 Regulations, Kenneth F. Thomas, William R. Stromsem May 2025

Washington Report: Aicpa Comments On Modified Proposed Circular 230 Regulations, Kenneth F. Thomas, William R. Stromsem

Tax Adviser

No abstract provided.


Consolidated Foreign Tax Credit (Part Ii), John L. Kramer, Robert L. Gardner May 2025

Consolidated Foreign Tax Credit (Part Ii), John L. Kramer, Robert L. Gardner

Tax Adviser

No abstract provided.


Estate Planning: Significant Recent Developments Concerning Estate Planning (Part I), Byrle M. Abbin, David K. Carlson May 2025

Estate Planning: Significant Recent Developments Concerning Estate Planning (Part I), Byrle M. Abbin, David K. Carlson

Tax Adviser

No abstract provided.


Subchapter S Revision Act Of 1982 (Part I), Lorence L. Bravenec May 2025

Subchapter S Revision Act Of 1982 (Part I), Lorence L. Bravenec

Tax Adviser

No abstract provided.


The Tax Adviser, Volume 14, Number 3, March 1983, American Institute Of Certified Public Accountants May 2025

The Tax Adviser, Volume 14, Number 3, March 1983, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.


Tax Trends, Nicholas J. Fiore May 2025

Tax Trends, Nicholas J. Fiore

Tax Adviser

No abstract provided.


Understatement Of Liability, Lynne E. Faigen May 2025

Understatement Of Liability, Lynne E. Faigen

Tax Adviser

No abstract provided.


Washington Report: Tax Division’S Suggested Questions And Answers On Sec. 6661 “Substantial Understatement Of Liability”, Kenneth F. Thomas, Robert E. Clayton, American Institute Of Certified Public Accountants. Federal Tax Division May 2025

Washington Report: Tax Division’S Suggested Questions And Answers On Sec. 6661 “Substantial Understatement Of Liability”, Kenneth F. Thomas, Robert E. Clayton, American Institute Of Certified Public Accountants. Federal Tax Division

Tax Adviser

No abstract provided.