Digital Commons Network^™

Advances In And Applications Of Capillary Scale Liquid Chromatography, Samuel William Foster

Theses and Dissertations

Analytical-scale high performance liquid chromatography (HPLC) is one of the most widely used analytical techniques in the world. Efforts have been made to reduce the mobile phase consumption of HPLC by reducing the inner diameter (I.D.) of the column. By using capillary-scale columns (< 0.5 mm I.D.), separations can be performed with orders of magnitude less solvent consumption. This work describes advances made to capillary scale instrumentation as well as applications enabled by these advances. A compact capillary-scale LC was used for the analysis of numerous pharmaceutical and illicit drug compounds for point of need analysis. A miniaturized mass spectrometer was coupled to this instrument for on-line reaction monitoring within a standard chemical fume hood. Kinetic profiles of commercially available capillary columns were developed in order to provide guidance to others during column selection. The implementation of a column oven improved the analysis of large biopharmaceuticals. Several critical quality attributes of monoclonal antibodies including fragmentation, charge variants, and glycosylation profiles were able to be determined on the capillary scale. These results will help to make capillary-scale liquid chromatography a more viable solution for chromatographic analysis.

Age, Provenance, And Geochemical Relationships Amongst The Great Valley Group, Coast Range Ophiolite, And Franciscan Subduction Complex At Del Puerto Canyon, Central California, Devon A. Orme, Natalee Weis, Kathleen D. Surpless, Andrew K. Laskowski, James L. Crowley, Nicole Stine, Ian Colliver, Carly Ross, Emma Sweet

Earth and Environmental Geosciences Faculty Research

The Great Valley Forearc (GVF) basin of California, USA, preserves an extensive rock record of the Jurassic–Paleogene tectonic development of the California segment of the North American Cordillera. We present new U-Pb geochronology, zircon and whole-rock geochemistry, and petrographic analyses from the Great Valley Group (GVG), Franciscan subduction complex, and Coast Range Ophiolite (CRO) in the northern San Joaquin Valley to better understand the timing and location of initial forearc sedimentation, and how sediment routing systems may have evolved during Cretaceous time. Basal GVG strata of the Knoxville Formation were deposited ca. 145–140 Ma and are separated by an ~40 …

From Lists To Infinite Scroll: A Comparative Analysis Of Youtube’S Two Recommendation Algorithms, Selimhan Dagtas

Theses and Dissertations

As social media platforms increasingly dominate information consumption, the role of recommendation algorithms in determining user experience has grown both in complexity and impact. This thesis investigates the behavioral patterns and algorithmic preferences embedded within YouTube’s recommendation systems, comparing long- form videos with the rapidly growing category of short-form content, YouTube Shorts. Through a combination of automated data collection, engagement metric analysis, emotional sentiment detection, and toxicity assessment, this study analyzes the evolution of content over successive recommendation depths. Using a controlled digital environment, the research explores how content recommendations change in response to user behavior, including varying watch times …

Sire Evaluations: Boer, Kiko, And Spanish Kid Weaning Weights In The Southeast, Alicia D. Aldridge

Tennessee State University Alumni Theses and Dissertations

Sire Evaluations: Boer, Kiko, And Spanish Kid Weaning Weights in the Southeast Research was completed with weaning weight ratio (WWR) and expected progeny difference (EPD) efficiency values compared from pedigree data across six seasons (2003-2009). Four models: WWR, 90- day unadjusted, adjusted, and new adjusted WW models compared sire breed, dam breed, month of birth, dam age, sex, litter size at birth, litter size at 90 day weaning age, and birth year effects. Correction factors were re-adjusted when non-genetic effects (sex, dam age, and litter size at birth and weaning) remained significant (p<0.05) in the original 90-day adjusted WW models. The new correction factors eliminated non-genetic effects (p>0.05). Sire breed effects were not significant …

Sensory Evaluation Of Cowpeas And Consumer Science Preference At Two Universities In The United States, Zaira Adams

Tennessee State University Alumni Theses and Dissertations

Throughout the past years, since the Covid pandemics, global inflation and food insecurity have been on a constant incline (What is Food Insecurity, World Food Bank). In this research study, we explore consumer preference for canned legumes (beans and peas) as an inexpensive nutritional intervention to decrease the number of households experiencing food insecurity. The solution is based on the food sensory analysis of cowpeas (Black-Eye Peas), crowder peas, black beans, and pinto beans. Our main geographical locations included studies at two Land Grant Universities in the United States (Pennsylvania State University and Tennessee State University). At Pennsylvania State, we …

Navigating Sorghum Bicolor Microspores For Genetic Transformation Via Androgenic Pathway During Gametogenesis, Aron M. Felts

Tennessee State University Alumni Theses and Dissertations

This study delves into the use of the androgenesis pathway of microspores for genetic transformation and double haploid production in Sorghum bicolor. Focusing on the environmental and genetic factors that affect androgenesis, in vitro culture techniques were aimed to be refined for utilizing microspores towards callus induction more effectively. These efforts yielded promising approaches for agronomic traits enhancements. This research enhances the methodology for plant regeneration from microspores, facilitating the generation of homozygous lines with potentially improved traits. Although the current findings do not mark a radical departure from existing knowledge, they lay essential groundwork for future genetic studies in …

Privacy-Preserving Ai Framework Using He-Fl For Electric Utility Infrastructure Defect Detection, Tupac S. Moseley

Tennessee State University Alumni Theses and Dissertations

In modern times, electric utility companies are utilizing on-ground and aerial drone imagery to identify physical defects on transmission and distribution infrastructure to plan for more effective maintenance. To deploy faster and more cost-efficient maintenance decisions, utility companies are considering developing automation tools powered by AI. However, for AI technology to be effectively trained for real-world implementation, there is a need for cross-collaboration among a vast number of utility companies to share their imagery and analysis to improve the global AI model. The primary challenge of this collaboration comes at the expense of requiring data cleaning, a manual process to …

Our Hbcus Matter: Factors Influencing Hbcus’ Graduation Rates, Brandon Markelle Graham

Tennessee State University Alumni Theses and Dissertations

This qualitative comparative multi case study examined how institutional practices, leadership philosophies, and academic support systems affect Pell Grant recipients' student success at Atlantic A&M University (AAMU) and Heritage State University (HSU). Based on Swail's Geometric Model of Student Persistence and Achievement, the study examined cognitive, institutional, and social factors of student success using institutional data, NCES datasets, and two former HBCU presidents' perspectives. Semi-structured interviews with former tenured HBCU presidents illuminated how financial constraints, performance-based accountability metrics, and admissions standards shaped campus strategies from 2012 to 2021. The study examined first-time, first-year Pell Grant recipients' graduation outcomes, standardized test …

Evaluating Safety Assurance Of Ai Classifiers Trained On Systematically Generated Sar Imagery, Branndon Jones

Tennessee State University Alumni Theses and Dissertations

The collection and curation of high-quality data is crucial for developing robust and trustworthy deep learning (DL) models. Due to the costly and time-consuming nature of gathering well-annotated data, researchers have shifted to supplementing network training with synthetic data. However, when solely training AI classifiers with synthetic data, the network performance when exposed to data from real environments may not be satisfactory. To mitigate this shortcoming, a Gen-AI model was developed to systematically generate annotated, context-controlled synthetic imagery datasets using real SAR imagery. Through this process, SAR images of targets of interests are initially semantically segmented and introduced onto the …

Short Communication: Multiscale Topographic Complexity Analysis With Pytopocomplexity, L. S.-H. Lai, Adam Booth, A. R. Duvall, E. Herzig

Geology Faculty Publications and Presentations

TopoComplexity is a Python package designed for efficient and customizable quantification of topographic complexity using four advanced methods: two-dimensional continuous wavelet transform analysis, fractal dimension estimation, rugosity index, and terrain position index calculations. This package addresses the lack of open-source software for these advanced terrain analysis techniques essential for modern geomorphology and geohazard research, enhancing data comparison and reproducibility. By assessing topographic complexity across multiple spatial scales, pyTopoComplexity allows users to identify characteristic morphological scales of studied landforms. The software repository also includes a Jupyter Notebook that integrates components from the surface-process modeling platform Landlab (Hobley et al., 2017), facilitating …

Measuring Emotional Intelligence With The Msceit 2: Theory, Rationale, And Initial Findings, John D. Mayer, David R. Caruso, Peter Salovey, Iris Y. Lin, Braden J. Hansma, Joanna Solomon, Gill Sitarenios, Manolo Romero Escobar

UNH Personality Lab

Introduction: The model of emotional intelligence as an ability has evolved since its introduction 35 years ago. The revised model includes that emotional intelligence (EI) is a broad intelligence within the Cattell-Horn-Carroll (CHC) model of intelligence, and that more areas of problem solving are involved than originally detailed. An argument is made here that veridical scoring of EI test responses is a sound procedure relative to scoring keys based on expert consensus or a single emotion theory. To the degree that EI fits present-day theories of intelligence (i.e., the CHC model), any subsidiary factors of EI reasoning should correlate highly …

Detection Modelling Of Four Major Organic Acids In The Base Wine Of Fuyuxiangxing Crude Baijiu Based On Near-Infrared Spectroscopy, Zhang Yunxia, Yu Ji, Li Yuntong, Yu Bing, Jin Xiqing, Yao Maojun

Food and Machinery

［Objective］ To rapidly quantify four major organic acids in 47 base wines of Fuyuxiangxing crude Baijiu using near -infrared spectroscopy (NIR) and chemometrics.［Methods］ The study used the Kennard -Stone (K-S) algorithm to divide the samples,combined with preprocessing strategies such as normalization,standard normal variate transformation (SNV ),and Savitzky -Golay smoothing.Model parameters were optimized through cross -validation,and the effects of the number of principal components and band selection on the performance of the principal component regression (PCR ) and partial least squares regression (PLSR ) models were evaluated.［Results］］ The validation results showed that the prediction correlation coefficients (R2c) of the PCR models …

Hudson Shore Associates Limited Partnership, Haven On The Hudson Llc, Kenneth Levinson, And Hudson Valley Property Owners Association Et Al. V. State Of New York, New York State Division Of Housing And Community Renewal, Village Of Nyack, New York, And City Of Poughkeepsie, New York

All Decisions

Landlords challenged New York's Vacancy Provisions, alleging Fourth Amendment violations for warrantless searches of rent rolls and Fourteenth Amendment due process violations concerning vacancy calculations. The court affirmed dismissal, holding that Article 78 proceedings provide sufficient pre-compliance review for record demands, and the low risk of coercion mitigates Fourth Amendment concerns. Due process was satisfied by opportunities for landlords to contest vacancy calculations through public hearings and subsequent Article 78 review, ensuring constitutional muster.

Gnss Technology, Utah State University Space Dynamics Laboratory

Space Dynamics Laboratory Publications

SDL presentation on GNSS Technology

Longitudinal Outcomes Of The Covid-19 Pandemic On Youth Physical Fitness, Andjelka Pavlovic, David Leonard, Timothy J Walker, Derek W Craig, Jizyah Injil, Laura F Defina

Faculty, Staff and Student Publications

Importance: The COVID-19 pandemic led to a decline in physical activity levels among youths, which could have a negative impact on their fitness.

Objective: To examine longitudinal changes in cardiorespiratory fitness (CRF) and musculoskeletal fitness (MSF) among students at schools participating in a school-based physical activity program during fall 2019 through spring 2023.

Design, setting, and participants: This longitudinal cohort study included US schools reporting CRF and MSF data at least once during the pandemic (fall 2020 to fall 2021) and at least 1 additional time before or after. In a subset of schools for which learning modality data was …

Lived Experiences Of Sex Offenders On Probation With Housing And Employment, Katheryn Winslow

Walden Dissertations and Doctoral Studies

Lived Experiences of Sex Offenders on Probation with Housing and Employment by Katheryn Winslow MA, South University, 2013 BS, University of Central Florida, 2010 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Psychology Walden University May 2025

Association Between Health Insurance, Antiretroviral Treatment, And Hiv Preexposure Prophylaxis In Men Aged 20–85 In Virginia, Lauren Elizabeth Maxwell

Walden Dissertations and Doctoral Studies

HIV prevention and treatment disparities persist among men in Virginia, particularly in racial and ethnic minority groups. This study examined how insurance type and demographic factors influence prescriptions for antiretroviral treatment (ART) and preexposure prophylaxis (PrEP). Addressing these disparities is critical to advancing public health equity and reducing HIV rates. The purpose was to assess whether age, race, ethnicity, region, and insurance type are associated with the type of oral HIV medication prescribed. Guided by the HIV prevention and care cascade frameworks, the study focused on access and adherence. Using a cross-sectional quantitative design, the study analyzed secondary data from …

Staff Education To Improve Nurses’ Knowledge On Medication Administration Error Prevention, Francoise Tabe

Walden Dissertations and Doctoral Studies

This staff education project aimed to enhance nurses’ knowledge on medication administration error prevention through targeted education interventions. Medication administration errors are a significant concern in health care, leading to patient harm and reduced quality of care. This project addressed the gap in nursing knowledge regarding strategies to prevent these errors, with the goal of improving patient safety and outcomes. The practice-focused question explored in this project was the following: How does implementing an education program affect nurses’ knowledge and practices related to medication error prevention? The purpose of this doctoral project was to educate nurses on best practices for …

The Effects Of Post Activation Potentiation Using Accommodating Resistance, Brennan Sweet

Doctorate in Kinesiology

Post activation potentiation is the short increase of power output following a heavy exercise. This effect could be due to several mechanisms, the most popular are increased sensitivity of actin and myosin to calcium or alpha motoneuron reactivity. The idea behind using the accommodating resistance is that eccentrics get lighter throughout the movement to avoid sticking points whilst changing the strength curve of the exercise. This may cause a greater stretch reflex and create more force from the weakest position of the movement because of the eccentrics being quicker also known as. Using accommodating resistance may also be less fatiguing …

A Comprehensive, Multi-Center, Immunogenomic Analysis Of Melanoma Brain Metastases, Lucy Boyce Kennedy, Amanda E D Van Swearingen, Marissa R Lee, Layne W Rogers, Alexander B Sibley, Jeff Sheng, Dadong Zhang, Xiaodi Qin, Eric S Lipp, Swaminathan Kumar, Aron Joon, Pixu Shi, Michael A Davies, Kouros Owzar, Carey K Anders, April K S Salama

Faculty, Staff and Student Publications

Background: Melanoma brain metastases (MBM) have a unique molecular profile compared to extracranial metastases (ECM). Description of the biological features and clinical outcomes of MBM will facilitate the design of rational therapies.

Methods: We examined the mutational landscape and gene expression profiles of MBM (74 patients) and ECM (34 patients) in paired patient samples from a previously published dataset with whole-exome sequencing (WES) and RNA sequencing (RNAseq) data from MD Anderson Cancer Center (MDACC). We also present findings from MBM from a new cohort of 14 patients from Duke University to strengthen investigation of somatic mutations and gene expression profiles. …

Counselor Education: Digital Delivery With Confidence, Nicole Marie Arcuri-Sanders, Alisha Davis

Educational Sciences and Organizations

Counselor education programs are required to demonstrate a clear framework, effective implementation, and overall program effectiveness. The pandemic’s surge in online instruction influenced CACREP’s (2024) digital delivery (DD) standards, addressing ethical and legal implications alongside student outcomes. Guidance from digital health initiatives, telemental health ethics and legal practices can be invaluable in clarifying DD protocols for counselor education programs. Understanding the parallels between DD and digital health regulations (e.g., HIPAA, ACA [2014], and NBCC [2023] ethical codes) provides a solid foundation for protecting both students and programs. Integrating technology and modeling digital health practices can enhance counselor education, benefiting both …

Harnessing Electrophiles In Vivo: A Pilot Study In Swine Using A Hydrophobic Radiopaque Formulation Of 2-Propylpentanoyl Chloride, Erik Cressman, Danielle Stolley, Natalie Fowlkes, Edd Felix, Waldemar Priebe, Steve Parrish, David Fuentes

Faculty, Staff and Student Publications

Manipulating biology through chemistry is older than the discipline of chemistry itself. Traditionally, selectivity of oral or intravenous drugs relied on preferential drug-receptor binding. A novel approach exploiting image-guided techniques to impart spatial selectivity opens up a wide range of new possibilities for study and manipulation of biology. Motivated initially by the poor prognosis for solid tumors such as liver cancer, we demonstrate the use of an extreme form of in vivo chemistry for targeted delivery of 2-propylpentanoyl chloride in a swine model. The ensuing reaction in tissue devitalizes it by multiple mechanisms with lasting effects and, critically, demonstrates very …

Bedford 203 Lp V. Santana

All Decisions

In a nuisance holdover case, the court partially granted the tenant's motion to dismiss, specifically dismissing allegations that the tenant's behavior "annoyed" other tenants, as the lease required a notice to cure for such conduct, which the landlord failed to provide. However, the court allowed the remaining nuisance allegations to stand, finding no notice to cure was required for conduct impacting building staff or the landlord's guests. The court also permitted the landlord to amend the petition to correctly reflect the apartment's regulatory status as part of the NYC 15/15 Project Based Program, finding no prejudice to the tenant.

Rojas V. Cruger Associates Limited Partnership

All Decisions

In this source of income discrimination case, the plaintiff tenant, obtained a preliminary injunction preventing the landlord, from commencing a nonpayment proceeding. The court found that the landlord repeatedly obstructed tenant's attempt to use her Emergency Housing Voucher for "leasing in place" by refusing to submit necessary paperwork, citing arrears, and failing to provide a valid Tax ID. The injunction was granted to preserve tenant's voucher and residency, emphasizing the landlord's obligation under New York City and State Human Rights Laws to accept lawful sources of income.

Estimated Burden Of Coccidioidomycosis, Samantha L Williams, Andrej Spec, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Coccidioidomycosis is an underrecognized fungal infection that can cause serious illness and constitutes a considerable public health burden. The number of cases is likely substantially higher than the nationally reported total, as surveillance does not capture patients who do not seek medical care or who are undiagnosed or misdiagnosed. Coccidioidomycosis is not reportable in all states, and cases not reported to public health entities are likewise missed. A systematic estimate of coccidioidomycosis burden is needed to raise awareness and inform public health interventions and policy.

OBJECTIVE: To assess the annual burden of symptomatic coccidioidomycosis in the US.

DESIGN, SETTING, …

Climatologist Mann's Defamation Suit Victory: Can It Resolve The Crisis Of Expertise, David S. Caudill

Faculty Publications

When a jury awarded one million dollars in punitive damages to climatologist Michael Mann, in his defamation suit against writer Mark Steyn (who accused Mann of scientific fraud), it was newsworthy, even surprising, because opinions regarding scientific matters are rarely actionable. And yet it was not seen as a groundbreaking event in terms of legal doctrine, since the outcome was easily justifiable— Steyn’s accusation was provably false. However, even if the Constitutional contours of defamation law did not change, the Mann verdict has far-reaching implications for a major contemporary social phenomenon, namely the so-called crisis of expertise, a term identifying …

Iron Deficiency Without Anemia And Reduced Basal Ganglia Iron Content In Youths, Dimitri Fiani, Joo-Won Kim, Mianzhi Hu, Ramiro Salas, Sarah Heilbronner, Jacquelyn Powers, Muhammad Haque, Stephanie Dinh, Xiaofan Huang, Darrell Worthy, Sridevi Devaraj, Junqian Xu, Chadi Calarge

Faculty, Staff and Students Publications

Importance: Although brain iron is necessary for neurogenesis, myelination, and neurotransmitter synthesis, iron deficiency (ID) is defined solely based on hematological outcomes.

Objective: To examine the association of ID without anemia with basal ganglia (BG) iron content and its structural and functional sequelae in adolescents.

Design, setting, and participants: This cross-sectional study enrolled participants using the electronic medical record system from a large network of pediatrics clinics between December 2020 and April 2024. Otherwise healthy, unmedicated participants aged 10 to 17 years with a depressive or anxiety disorder or with no psychopathology were consecutively enrolled. Anemia and acute inflammation led …

Evaluation Of Social Worker Knowledge Of Human Trafficking At The Oregon State Hospital: A Qualitative And Quantitative Analysis Of Education, Training, And Victim Identification, Jamie Sue Pryde

Dissertations and Theses

The prevalence of human trafficking continues to increase worldwide, and the implementation of human trafficking education and victim identification within institutions is slow to catch up. The Oregon State Hospital is a psychiatric in-patient hospital that currently does not provide human trafficking education or a screening tool for staff and does not know how to provide treatment to trafficked victims. Interviews were conducted with employed social workers at the Oregon State Hospital to obtain a baseline understanding of their previous education, training, and knowledge of human trafficking to aid in the creation of a trafficking screening tool. Results indicate participants …

Irx2 And Nptx1 Differential Regulation Of Β-Catenin Underlies Mek-Mediated Proliferation In Human Neuroglial Cells, Alexander Chen, Hannah Wang, Xuanwei Li, Corina Anastasaki, David H Gutmann

2020-Current year OA Pubs

The two major genomic alterations in pediatric pilocytic astrocytoma (PA) are

Evaluating Gamified Website Designs: An Analysis Using The Octalysis Framework, Menna Mohamed Zakaria, Reem Alasfoury, Nesrin Ezzat Gamal, Maryet Youssef Bekhit

Journal of Art, Design and Music

In today's fast-changing digital landscape, websites must stand out to gain and retain user attention. Gamification techniques, which use game-design concepts to improve user engagement and satisfaction, are a method to achieve this uniqueness. This research investigates the significant role of purposeful design in the effective application of gamification on websites, emphasising the importance of deliberate and balanced context-specific implementation of gamification By examining industry-leading websites that employ gamification using the Octalysis framework and related theoretical frameworks The findings highlight that, while gamification has the potential to dramatically distinguish the website and boost user interaction and loyalty, its performance and …