Digital Commons Network^™

Kap1 Promotes Gastric Adenocarcinoma Progression By Activating Hippo/Yap1 Signaling Via Binding To Hnrnpab, Shumei Song, Yibo Fan, Gengyi Zou, Longfei Huo, Janani Kumar, Yuan Li, Ruiping Wang, Enyu Dai, Jiankang Jin, Ailing W Scott, Shan Shao, Melissa Pool Pizzi, Jody V Vykoukal, Hiroyuki Katayama, Samir Hanash, George A Calin, Xing Zhang, Min Gyu Lee, Zhenning Wang, Yuan-Hung Lo, Qiong Gan, Rebecca E Waters, Feng Yin, Linghua Wang, Xiaodong Cheng, Jaffer A Ajani, Shilpa S Dhar

Faculty, Staff and Student Publications

Gastric adenocarcinoma (GAC) remains a significant global health challenge, with over a million new cases annually. Peritoneal carcinomatosis (PC), detected in ∼20 % of cases at diagnosis and ∼45 % later, is uniformly fatal, with limited treatment options. This study investigated the role of KAP1 in GAC progression, focusing on its interaction with YAP1 and cancer stemness traits. Analysis of over 596 primary GACs and 72 PC samples revealed that high nuclear KAP1 expression correlates with poor prognosis. KAP1 knockdown reduced oncogenic activity and stemness traits in GAC cells. Mechanistically, KAP1 positively regulates YAP1 transcription by binding to its promoter …

Semi-Automated Hippocampal Avoidance Whole-Brain Radiotherapy Planning, Dong Joo Rhee, Subha Perni, Kelly J Perrin, Kevin E Casey, Alexandra O Leone, Callistus M Nguyen, Laurence E Court, He Wang, Xin Wang, Eun Young Han

Faculty, Staff and Student Publications

Background: Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) is designed to spare cognitive function by reducing radiation dose to the hippocampus during the treatment of brain metastases. Current manual planning methods can be time-consuming and may vary in quality, necessitating the development of automated approaches to streamline the process and ensure consistency.

Purpose: To automate hippocampal avoidance whole-brain radiotherapy (HA-WBRT) planning.

Methods: Our algorithm automatically contours organs-at-risk (OARs) and the hippocampal-avoidance brain target. The algorithm generates planning structures from given contours, utilizing preset beam parameters and dose constraints for optimization. If the dose constraints are unmet, "hotspot" contours will be created to …

1d Thermoembolization Model Using Ct Imaging Data For Porcine Liver, Rohan Amare, Danielle Stolley, Steve Parrish, Megan Jacobsen, Rick R Layman, Chimamanda Santos, Beatrice Riviere, Natalie Fowlkes, David Fuentes, Erik Cressman

Faculty, Staff and Student Publications

Innovative therapies such as thermoembolization are expected to play an important role in improving care for patients with diseases such as hepatocellular carcinoma. Thermoembolization is a minimally invasive strategy that combines thermal ablation and embolization in a single procedure. This approach exploits an exothermic chemical reaction that occurs when an acid chloride is delivered via an endovascular route. However, comprehension of the complexities of the biophysics of thermoembolization is challenging. Mathematical models can aid in understanding such complex processes and assisting clinicians in making informed decisions. In this study, we used a Hagen-Poiseuille 1D blood flow model to predict the …

A Follow-Up Study On The Novel Use Of Contrast-Enhanced Susceptibility-Weighted Imaging For Extremity Desmoid Fibromatosis Response Assessment, Raul F Valenzuela, Elvis Duran-Sierra, Mathew Antony, Behrang Amini, Sam Lo, Keila E Torres, Ken-Pin Hwang, Jingfei Ma, R Jasson Stafford, Ravin Ratan, John E Madewell, Dejka Araujo, William A Murphy, Colleen M Costelloe

Faculty, Staff and Student Publications

Desmoid tumors are rare mesenchymal neoplasms characterized by a clonal proliferation of fibroblasts and myofibroblasts. Using the novel contrast-enhanced susceptibility-weighted imaging (CE-SWI) for characterizing desmoid tumors can enhance the separation between fibrous T2-hypointense and cellular T1-enhancing components. We aim to evaluate the effectiveness of the CE-SWI signal, volumetric, and radiomics-derived features in assessing desmoid treatment response. This IRB-approved study included 17 single-lesion extremity desmoid fibromatosis patients who underwent standard-of-care MRI, including CE-SWI, from March 2021 to February 2024. Measurements of maximum diameter, volume, and the modified Choi (m-Choi: tumor/muscle T2 ratio) were computed based on CE-SWI and T2-STIR volumetric tumor …

The Sports-Betting Market: A Road To Sports Betting As Viable Investing, Tyler Gottlieb

Vanderbilt Journal of Entertainment & Technology Law

Since its legalization, sports betting has experienced rapid growth, both in terms of economic output and expansion into more states. The current system of sports betting in the United States requires individuals to place bets using a sportsbook. The sportsbook sets the lines on every bet. If an individual wins their bet, the sportsbook pays them money according to the listed odds. If an individual loses their bet, the sportsbook keeps the amount staked. Sportsbooks set lines in a way to ensure that on average, they make money on every bet. This system has been widely accepted, often based on …

Cdemapper: Enhancing National Institutes Of Health Common Data Element Use With Large Language Models, Yan Wang, Jimin Huang, Huan He, Vincent Zhang, Yujia Zhou, Xubing Hao, Pritham Ram, Lingfei Qian, Qianqian Xie, Ruey-Ling Weng, Fongci Lin, Yan Hu, Licong Cui, Xiaoqian Jiang, Hua Xu, Na Hong

Faculty, Staff and Student Publications

Objective: Common Data Elements (CDEs) standardize data collection and sharing across studies, enhancing data interoperability and improving research reproducibility. However, implementing CDEs presents challenges due to the broad range and variety of data elements. This study aims to develop a CDE mapping tool to bridge the gap between local data elements and National Institutes of Health (NIH) CDEs.

Methods: We propose CDEMapper, a large language model (LLM)-powered mapping tool designed to assist in mapping local data elements to NIH CDEs. CDEMapper has 3 core modules: (1) CDE indexing and embeddings. NIH CDEs were indexed and embedded to support semantic search; …

Assessing Health And Academic Disparities In The Deep South: The Enduring Impact Of Segregation And Redlining In Georgia, Bridget Hamilton

Theses and Dissertations

Background: Within the American South, marginalized Black populations continue to suffer from health disparities. A key resource that could aid in the prevention of health disparities such as teen pregnancy is the school nurse. School nurses are well positioned to assist in the development of independent health maintenance among student populations. However, school nurses remain understaffed and underfunded throughout most of the United States, which limits their effectiveness. It is possible that within southern states there are inequities in how school resources are allocated that have ties to segregation and redlining practices that systemically marginalized Black populations throughout the 1900s. …

Embeddable Multi-Material Wireless Micro-Sensors Utilizing Additive Manufacturing And Enhanced Microstructure, Nicholas Reed

Doctoral Dissertations and Master's Theses

The development of embeddable, multi-material wireless microsensors offers transformative potential for structural health monitoring (SHM) in aerospace applications. This work integrates additive manufacturing (AM) techniques with advanced microstructural design to produce flexible, high-resolution sensors that can be directly embedded into polymer substrates. By utilizing the vat photopolymerization process, customized embedded sensors are seamlessly integrated into polymer AM structures. These sensors are then continuously refined, targeting increases in performance, both internal and external. Microstructural enhancements are explored to modify the rheological properties of the fabricated embedded sensing channels and enhance the adhesive bonding between the embedded sensor and the AM structure. …

Stability Analysis Of The Eulerian-Lagrangian Finite Volume Methods For Nonlinear Hyperbolic Equations In One Space Dimension, Yang Yang, Jiajie Chen, Jing Mei Qiu

Michigan Tech Publications

In this paper, we construct a novel Eulerian-Lagrangian finite volume (ELFV) method for nonlinear scalar hyperbolic equations in one space dimension. It is well known that the exact solutions to such problems may contain shocks though the initial conditions are smooth, and direct numerical methods may suffer from restricted time step sizes. To relieve the restriction, we propose an ELFV method, where the space-time domain was separated by the partition lines originated from the cell interfaces whose slopes are obtained following the Rakine-Hugoniot junmp condition. Unfortunately, to avoid the intersection of the partition lines, the time step sizes are still …

Chronic Illness Education 2025: Education And Resources To Improve Pediatric Type I Diabetes Mellitus Care Within Schools And Child Care Services, Alexander Seidel, Alexandra Thomas, Christine Larrea, Daven Sarikonda, Jack Gurwin, Maria Karla Bermudez Pineiro, Matthew Mello, Sana Soman

Patient Education Projects

No abstract provided.

A Quantitative Examination Of The Sexual Health Of Aging Black Men In Rural South Africa, Esihle Lupindo

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation uses survey data primarily from Wave 1 of the Health and Aging in Africa: Longitudinal Study of In-depth Community in South Africa (HAALSI) which was collected in 2015 to study the sexual health of Black men in rural Mpumalanga, South Africa. Broadly speaking, I examine aging men’s sexual health as it related to HIV, well-being, loneliness, social networks and disclosure. The definition that I use for sexual health was coined by MacPhail and Campbell (2001) who define it as “not only sexual practices but also what people know and believe about sex, particularly what they think is natural, …

Harnessing Zakat To Drive Inclusive Economic Growth: Prospects And Challenges, Moh Najikhul Fajri, Andini Kusumawardhani

Journal Of Middle East and Islamic Studies

This study aims to analyze the role of zakat in promoting local inclusive economic growth in Indonesia. This research uses secondary panel data of 34 provinces during 2017-2022. The analysis techniques used in this study include the Poverty Equivalent Growth Rate (PEGR) inclusive economic growth measurement method and the Static Panel Regression Fixed Effect Model. This study concludes that zakat is proven to be an effective instrument in promoting inclusive economic growth in Indonesia, with a significant impact on income distribution even though its potential is still not optimized. Unique findings reveal that inclusive growth recovered faster than GDP post-pandemic, …

Extubation Decisions With Predictive Information For Mechanically Ventilated Patients In Icu, Guang Cheng, Jingui Xie, Zhichao Zheng, Haidong Luo, Oon Cheong Ooi

Research Collection Lee Kong Chian School Of Business

Weaning patients from mechanical ventilators is a crucial decision in intensive care units (ICUs), significantly affecting patient outcomes and the throughput of ICUs. This study aims to improve the current extubation protocols by incorporating predictive information on patient health conditions. We develop a discrete-time, finite-horizon Markov decision process with predictions of future state to support extubation decisions. We characterize the structure of the optimal policy and provide important insights into how predictive information can lead to different decision protocols. We demonstrate that adding predictive information is always beneficial, even if physicians place excessive trust in the predictions, as long as …

Enhancing Phenotyping Accuracy For Selection Of Urochloa Spp. Tolerant Genotypes To Red Spider Mite (Oligonychus Trichardti), Paula Espitia-Buitrago, José Miguel Cotes Torres, Luis Miguel Hernández, Juan Andres Cardoso, Frank Chidawanyika, Rosa N. Jauregui

All Peer-Reviewed Publications

The red spider mites are a major biotic limitation to productivity for Brachiaria (Urochloa spp.) grasses in tropical Eastern Africa, causing severe economic losses mainly in the dry seasons. However, due to the lack of reports of integrated pest management strategies, genetic resistance can play a crucial role in Brachiaria-based livestock systems, minimising the impact of this pest. The objective of this study was to develop and validate a methodology for accurately categorising resistance responses in Urochloa genotypes to identify potential sources of resistance to the Western Kenya red spider mite Oligonychus trichardti (Meyer 1974). Accordingly, 25 genotypes of Urochloa …

Hernia Recurrence Risk Matters More Than Mesh Type To Patients Undergoing Ventral Hernia Repair, Stephanie Martinez Ugarte, Mokunfayo O Fajemisin, Chelsea J Guy-Frank, Dalya M Ferguson, Jonah J Stulberg, Lillian S Kao, Julie L Holihan

Faculty, Staff and Student Publications

Introduction: Patients' perceptions about synthetic mesh for ventral hernia repair (VHR) may stem from a lack of knowledge of risks. We assessed patients' threshold for accepting the risk of hernia recurrence to avoid synthetic mesh.

Methods: Patients ≥18 y old with prior or upcoming VHR viewed a one-time video decision aid describing recurrence risk with biologic versus synthetic mesh. Patients chose between these options using a probability trade-off (PTO) technique, varying hernia recurrence rate with biologic mesh. Based on randomized trials, the recurrence rate using synthetic mesh was 9%. The PTO score was the recurrence rate (0%-100%) at which patients …

Mixed Quantum/Classical Theory Approach To Rotationally Inelastic Molecular Collisions Implemented On A Quantum Computer, Jonathan Andrade-Plascencia, Tamila Kuanysheva, Dulat Bostan, Brian K. Kendrick, Dmitri Babikov

Chemistry Faculty Research and Publications

All elements of a quantum algorithm for calculations of rotationally inelastic molecule + atom scattering within the framework of a mixed quantum/classical theory are outlined. In this approach, the rotational motion of the molecule is described quantum mechanically using the time-dependent Schrödinger equation, while the scattering process of two collision partners is treated classically. The matrix of potential coupling is precomputed on a classical processor, whereas the quantum hardware is used to propagate the system of coupled equations for the rotational state-to-state transitions. All quantum circuits needed for practical implementation of the algorithm are presented. First, the quantum codes written …

Engage & Empower: Foundations Of Social Work Practice, Elhanan Marvit

Open Touro Created

2025

Engage & Empower: Foundations of Social Work Practice is an open educational resource for social work students in “foundations of social work practice” courses. It begins by explaining Open Educational Resources and their benefits. Students then explore social work fundamentals, including the diverse roles of social workers.

With this foundation, students engage with the NASW Code of Ethics’ key terms, and principles. This ethical grounding prepares them for the “growth work” needed to develop cultural competence and cross-cultural awareness. They then learn to apply various Generalist Practice skills across different-sized systems to empower client populations.

Next, the book explores …

Putting Police Body-Worn Camera Footage To Work: A Civil Liberties Evaluation Of Truleo’S Ai Analytics Platform, Farhang Heydari, Max Isaacs, Katie Kinsey, Barry Friedman, Christopher Slobogin, Alissa Marque Heydari

Cardozo Law Review

This Article summarizes findings from a civil liberties evaluation of Truleo, an AI-powered analytics platform designed to automate the review of police body-worn camera (BWC) footage. It includes a summary of how Truleo’s platform works, policy choices made by the company, and our assessment of safeguards and risks of the platform from a civil liberties perspective. This Article also offers a series of recommendations for policymakers considering the adoption of Truleo or similar technologies. These include the necessity for independent testing of claimed benefits, democratic authorization for deployment, and ongoing transparency and public input around the platform’s design and operation. …

Database Development For Reliable Small Object Detection In Maritime Environments, Jacob Matthew Whisenant

Theses and Dissertations

Achieving high reliability in small object detection is critical for advancing maritime and littoral intelligent navigation operations. Computer vision provides an undetectable form of perception that can be easily integrated into existing camera systems, offering a low-profile yet powerful solution for navigation and situational awareness in water-based environments. While deep learning techniques have significantly advanced the field of computer vision, the detection of small objects remains a persistent challenge. Limited pixel representation, the scarcity of large-scale small object datasets, and the reduced detail and indistinct features of small objects complicate detection efforts, especially in complex environments. These factors collectively hinder …

Aggressive, Adaptive, And Underestimated: From Allergy To Arboviruses, The Rise Of The Lone Star Tick, Emily Ellen Owens Pickle

Theses and Dissertations

Once considered a nuisance with little medical importance, the lone star tick (Amblyomma americanum, Acari:Ixodidae) has emerged as a formidable vector driving a new era of public health threats across the United States of America. This dissertation traces the rise of the lone star tick from obscurity to infamy, exploring its expanding geographic range, unique immunologic impacts on humans, and role in the transmission of emerging tickborne viruses. Through a series of integrated studies, this work characterizes the epidemiology, immunology, and ecological context of tick-borne diseases in the southeastern U.S., with a particular focus on α-Gal syndrome (AGS), …

Self-Efficacy And Mathematical Identities In A Rural Georgia Middle School Classroom, Gavin Wilson

Theses and Dissertations

Even into adulthood, some people have a strong resentment of math. Their beliefs toward their mathematical abilities have created a fear of the subject, resulting in an avoidance of anything math-related. These thoughts and beliefs regarding math and mathematical abilities begin somewhere along an individual’s academic journey in a math classroom. This action research study, using a mixed-methods approach, attempted to uncover the origins and development of self-efficacy and mathematical identities in rural eighth-grade students. Furthermore, this study explored ways that a teacher can influence these sets of beliefs and examined the impact on academic performance. The framework used to …

Multi-Task Deep Learning Approach For Segmenting And Classifying Competitive Swimming Activities Using A Single Imu, Mark Shperkin

Theses and Dissertations

Competitive swimming performance analysis has traditionally relied on manual video review and multi-sensor systems, both of which are resource-intensive and impractical for everyday training use. This study investigates whether a single wrist-worn inertial measurement unit (IMU) can be used to automatically segment and classify swimming activities with high accuracy. We propose a multi-task deep learning pipeline based on the MTHARS (Multi-Task Human Activity Recognition and Segmentation) architecture introduced by Duan et al. to perform stroke classification, lap segmentation, stroke count estimation, and underwater kick count estimation. Data were collected from eleven collegiate-level swimmers wearing left-wrist-mounted IMUs, each performing five 100-yard …

Process-Grounded Knowledge-Infused Learning And Decision Making, Kaushik Roy

Theses and Dissertations

This dissertation introduces process-grounded knowledge-infused learning and reasoning, a novel framework for integrating domain-expertise-based process knowledge into the learning and reasoning mechanisms of artificial intelligence systems. This approach is designed to produce controlled, transparent, and reliable predictions in critical tasks such as medical diagnosis and recommendation. By focusing on the case study of mental illness diagnosis and recommendation—where decision-making must be grounded in processes such as disorder-specific diagnostic criteria—this work demonstrates methods to embed structured decision-making directly into the system architecture during both training and inference. This integration facilitates end-to-end training and reasoning while ensuring that outputs strictly adhere to …

Circannual And Kinship Cues Shape Reproduction And Epigenetic Aging In Peromyscus, Kim Tuyen Huynh Dam

Theses and Dissertations

Evolutionary success is defined by the ability of a species to adapt and survive across many generations. This success is not determined by any single attribute but rather includes the entrenched, complex system that could be associated with biological rhythms, reproductive strategies, and regulations of epigenetic and genetic components. By using closed Peromyscus colonies as a model and by coupling mathematical modeling, analyses of breeding records, epigenetic studies, and in vitro and in vivo experiments, this dissertation aims to discover how Peromyscus adjusts to the internal and external pressures to ensure their survival and preserve evolutionary fitness in controlled environments. …

How Do People Discern Authenticity From Emotional Expressions, Sewon Oh

Theses and Dissertations

Emotional authenticity is a crucial element in the development and progression of social relationships. However, limited research has comprehensively examined how emotional authenticity perception is shaped by different communication channels, visual attention, and individual differences. This thesis aimed to investigate the emotional authenticity perception from multiple perspectives, including the feasibility of authenticity manipulation, the influence of multimodal cues, and visual attention allocation in assessing authenticity from facial expressions. Findings demonstrated that authenticity could be successfully manipulated by both professional and non-professional actors. Participants differentiated both authenticity and emotion most accurately in audiovisual expressions. The audio channel played an important role …

Action Research To Explore The Use Of Augmented Reality To Support High School Students In Understanding And Creating Art Work In A Drawing Course, Alicia Joanne Cobler

Theses and Dissertations

High school students in Drawing 1 at a high school in South Carolina struggle to understand meaning or make personal connections to their own artwork. The purpose of this action research was to evaluate the implementation of immersive reality technology, specifically augmented reality (AR), in art for high school Drawing 1 students to help them understand meaning in art and create their own meaningful artwork. Creating personally meaningful symbolic works of art is one of the first Visual Art National Core Standards (National Core Visual Art Standards, 2014). Creating meaning in artwork allows students to understand society, provide an opportunity …

Reduced Order Model-Based Framework For Microsecond Model Updating Of Two-Dimensional Structural Systems Using The Local Eigenvalue Modification Procedure, Emmanuel Abiodun Ogunniyi

Theses and Dissertations

Real-time model updating is crucial for active structures and electronic assemblies subjected to high-rate dynamic events. High-rate dynamic events refer to events that occur at high speeds and with rapid changes in the forces and energy involved. These events can include explosions, impacts, and crashes. These systems are characterized by a high dynamic response with a high rate (< 100 ms), high amplitude (> 100 gn), highly nonlinear, meaning that the response is not proportional to the applied force, and involve complex interactions between multiple objects or materials. A system exposed to high-rate dynamic environments is frequently prone to rapid plastic deformation, involving violent and …

Sensing Others, Alissa Reed

Theses and Dissertations

In this project, I notice how we listen and respond to animals, both through marine bioacoustics studies and rhetorical theory, and consider how we might develop new ways of noticing and interacting with animals. I hold together rhetorical theory, marine bioacoustics studies, and my observations nest sitting sea turtles to see what kind of multispecies ethic emerges from messy encounters with nonhuman others – specifically, with sea turtles nesting on the beaches of the Outer Banks in the Summer of 2020. By confronting the unavoidable moments of indecision, and even possible violence, inherent to encounters with nonhumans others, even and …

Regression With Atypical Data: Measurement Error, Periodicity, And Non-Normality, Nicholas W. Woolsey

Theses and Dissertations

Regression is a ubiquitous and fundamental method that can be found in any ele- mentary statistics course. The simplicity and self evidently useful nature of linear regression beguiles a non-negligible portion of researchers into disrespecting assump- tions required by these models, namely in terms of accuracy of covariates and the underlying nature of the data. This disregard can at best lead to meaningless results and at worse cause significant misunderstandings in scientific pursuit.

In this dissertation we strive propose remedies to violations of specific assump- tions. Namely the assumptions that covariates are either observed without measure- ment error or they …

Exploring The Ancestry And Mutational Signatures Of Free-Breeding Dogs From Chernobyl And The Galápagos Islands, Gabriella Jean Spatola

Theses and Dissertations

Two free-breeding dog populations, one in Chernobyl, Ukraine, and the other on the Galápagos Islands, Ecuador, exist on opposite sides of the globe, yet both hold unique scientific potential to further our understanding of free-breeding dog population dynamics and evolutionary processes related to their environments. In the following studies, blood samples from more than 400 individual Chernobyl dogs were collected and their genomes were analyzed alongside over 1500 purebred and 200 global free-breeding dogs, describing genetic relationships and the extent of admixture with purebred migrants. Importantly, the sampled Chernobyl dogs had long-term exposures to ionizing radiation because of the 1986 …