Digital Commons Network^™

An Integrative Genomics Approach For The Discovery Of Potential Clinically Actionable Diagnostic And Prognostic Biomarkers In Colorectal Cancer, Mark Fertel, Duaa Mohammad Alawad, Chindo Hicks

School of Graduate Studies Faculty Publications

Background: Despite remarkable progress in clinical management of patients and intensified screening, colorectal cancer remains the second most common cause of cancer-related death in the United States. The recent surge of next generation sequencing has enabled genomic analysis of colorectal cancer genomes. However, to date, there is little information about leveraging gene expression data and integrating it with somatic mutation information to discover potential biomarkers and therapeutic targets. Here, we integrated gene expression data with somatic mutation information to discover potential diagnostic and prognostic biomarkers and molecular drivers of colorectal cancer. Methods: We used publicly available gene expression and somatic …

Enhancing Diagnostic Reliability Through Centrifuge Validation And Staff Education: Quality Management Initiative In A Clinical Laboratory, Chris Agoki

MSMLS Capstone Projects

Abstract

This capstone project aims to enhance diagnostic reliability in a clinical laboratory by validating centrifuge performance and implementing an adult education-based training program within a quality management framework. Twenty archived, de-identified whole blood samples were analyzed to compare the performance of a new centrifuge with an existing model, focusing on plasma volume, hemolysis index, and Tacrolimus concentration.

The study demonstrated statistical and clinical equivalence between the devices, supporting the implementation of the new centrifuge. A staff training program, grounded in andragogical principles and guided by transformational leadership and Kotter’s 8-Step Change Model, was developed to integrate validation practices into …

Evolving Trends: A Bibliometric Analysis Of Academic Librarians’ Publications At Twelve Aau Member Universities, Pete E. Pascuzzi, Jason B. Reed, Greenley Goedde Creech

Libraries Faculty and Staff Scholarship and Research

The goal of this bibliometric study was to explore the broader publication patterns of academic librarians in both information and library science (ISLS) and interdisciplinary research for the years 2009 - 2023. Web of Science data were collected for twelve academic libraries. The results showed that while the number of ISLS publications has dropped, interdisciplinary publications have increased dramatically with a broad range of disciplines represented, and collaborations in the medical sciences were a major contributor to this increase. The study suggests that some academic libraries have shifted their priorities over the past fifteen years and that the assessment of …

Self-Determination In The Implementation Of Treaty Reserved Rights, Kekek Jason Stark

Tribal Law Journal

No abstract provided.

Stop Killing The Klamath: Rights Of Nature Protections With Tribal Law, The National Historic Preservation Act, And Collaborative Management Strategies For A Tribe On The Front Lines Of Climate Change, Juliette A. Jackson

Tribal Law Journal

No abstract provided.

From Imaging To Computational Domains For Physics-Driven Molecular Biology Simulations: Hindered Diffusion In Platelet Masses, Catherine House, Ziyi Huang, Kaushik Shankar, Sandra Young, Meghan Roberts, Scott Diamond, Maurizio Tomaiuolo, Timothy Stalker, Lu Lu, Talid Sinno

Cardeza Foundation for Hematologic Research

When formed in vivo, murine hemostatic thrombi exhibit a heterogeneous architecture comprised of distinct regions of densely and sparsely packed platelets. In this study, we utilize high-resolution electron microscopy alongside machine learning and physics-based simulations to investigate how such clot microstructure impacts molecular diffusivity. We used Serial Block Face - Scanning Electron Microscopy (SBF-SEM) to image select volumes of hemostatic masses formed in a mouse jugular vein, producing high-resolution 2D images. Images were segmented using machine learning software (Cellpose), whose training was augmented by manually segmented images. The segmented images were then utilized as 2D computational domains for Lattice Kinetic …

Moral Judgment Toward Individuals In Consensually Non-Monogamous Relationships As A Function Of Moral Foundations And Disgust Sensitivity, Dylan Selterman, Jeff Bowen, Ria Datwani, Amy C. Moors

Psychology Faculty Articles and Research

In two experiments we demonstrate how participants perceive individuals in consensually non-monogamous relationships (e.g., polyamory) more negatively compared to those in monogamous relationships, as a function of moral foundation variables and trait-level disgust sensitivity. In Study 1, we experimentally presented participants with vignettes depicting characters in one of two relationship types (monogamous or non-monogamous), after which participants completed character judgments (ethics) and relationship impressions. Participants viewed the characters in a monogamous relationship as more ethical and having higher relationship quality, and these associations were fully mediated by perceptions of the characters as pure, loyal, caring, fair, and honest. Participants high …

Sex-Specific Effects Of Early-Life Unpredictability On Hippocampal And Amygdala Responses To Novelty In Adolescents, Elysia Poggi Davis, Bianca T. Leonard, Robert J. Jirsaraie, David B. Keator, Steven L. Small, Curt A. Sandman, Victoria B. Risbrough, Hal S. Stern, Laura M. Glynn, Michael A. Yassa, Tallie Z. Baram, Jerod M. Rasmussen

Psychology Faculty Articles and Research

Background

Unpredictable childhood experiences are an understudied form of early-life adversity that impact neurodevelopment. The neurobiological processes by which exposure to early-life unpredictability impact development and vulnerability to psychopathology remain poorly understood. In the current study, we investigated the sex-specific consequences of early-life unpredictability on the limbic network, focusing on the hippocampus and the amygdala.

Methods

Participants included 150 youths (54% female). Early-life unpredictability was assessed using the Questionnaire of Unpredictability in Childhood (QUIC). Participants engaged in 1 or more task–functional magnetic resonance imaging scans between the ages of 8 and 17 (223 total observations) measuring blood oxygen level–dependent (BOLD) …

African American Women's Lived Experience Of The Process And Outcomes Of Psychotherapy For Depression, Eva Coleman Springs

Walden Dissertations and Doctoral Studies

The study of individuals’ experiences in psychotherapy has resulted in improvements in delivery of services to clients. The purpose of the current study was to use Aragon’s primary provider theory as the theoretical foundation to explore African American women’s perceptions of the process and outcomes of their psychotherapy for depression. Phenomenological methodology was used to explore a sample of nine African American women’s perceptions of the process and outcomes of their psychotherapy for depression and other mental health issues. Participants answered nine semi-structured interview questions to describe their experiences of at least one session of psychotherapy in the 2023 calendar …

Lower Your Expectation Damages: Bipa Reforms Amplify Need For Federal Standards In Biometric Data Privacy, Jessica Schmitz

Minnesota Journal of Law, Science & Technology

No abstract provided.

Why The Ai Act Fails To Understand Generative Ai, Claire Boine, David Rolnick

Minnesota Journal of Law, Science & Technology

No abstract provided.

Low Premorbid Iq May Exacerbate The Cognitive Effects Of Apolipoprotein Ε4 (Apoe Ε4): A Multi-Ethnic Cross-Sectional Study From Habs-Hd, Lubnaa B. Abdullah, Zhengyang Zhou, Ney Alex Alliey, Robert Barber, James Hall, Sid O’Bryant

Psychological Science Faculty Publications

Introduction: Apolipoprotein allele 4 (APOE ε4) is associated with lower IQ scores during childhood and adolescence, but the influence of APOE ε4 and low IQ on late-life cognition is unknown. This study examines the association between APOE ε4 and cognitive outcomes based on premorbid intellectual ability (pIQ) and ethnic background.

Methods: Participants were drawn from the Health & Aging Brain Study–Health Disparities (HABS-HD), categorized by low (z ≤ −2.00) or average (z = 0.00 ± 1.00) pIQ based on word reading scores. Statistical analyses were conducted to evaluate whether APOE ε4 was associated with the cognitive domains of …

Don’T Throw The Book: Customary Tribal Laws Can Heal Rather Than Punish Addiction, Coleman Griffith

Tribal Law Journal

No abstract provided.

Investigating Long-Lasting Meteor Train Phenomena In Optical And Radio Regimes, Logan E. Cordonnier

Physics & Astronomy ETDs

Throughout history, meteors have been regarded as fascinating and portentous events, with bygone astronomers diligently recording their occurrence. The research presented herein continues in this tradition, using modern instruments, software, and data reduction techniques to study long-lasting meteor trail phenomena, specifically in the optical (persistent trains; PTs) and radio (meteor radio afterglows; MRAs) regimes. The overarching goal was to investigate the similarities between these phenomena, which began with the creation of a PT catalog. Many of the prior assumptions about the nature of PTs were found to be unsubstantiated, and several new behaviors were uncovered. This includes the discovery of …

Brief Of Law Professors As Amici Curiae In Support Of Plaintiff-Appellees, Ira P. Robbins

Amicus Briefs & Court Filings

INTRODUCTION: The Executive Order at issue in these appeals targets a small and uniquely vulnerable minority of transgender women—those currently housed in federal women’s prisons—by commanding the Federal Bureau of Prisons (BOP) to transfer them immediately to men’s facilities. Amici file in support of Plaintiffs-Appellees (hereinafter “Plaintiffs”), to address two procedural arguments made by Defendants-Appellants (“the government”). First, Congress has not eliminated federal court jurisdiction to decide Plaintiffs’ challenge to the transfer provisions of the Executive Order. Second, the government overreads the Prison Litigation Reform Act (PLRA); Plaintiffs’ lawsuit is not improper or premature under that statute’s exhaustion requirement because …

Self-Determination In The Implementation Of Treaty Reserved Rights, Kekek Jason Stark

Faculty Law Review Articles

After fifty years of implementing tribal treaty reserved rights, this article will examine how tribal courts are determining cases involving treaty reserved rights and resources and to the extent tribal courts are recognizing and utilizing tribal customary law. This analysis will include a summary of tribal treaty harvest management systems and the how in the recognition of treaty reserved rights, federal courts have often limited tribes in their ability to fully implement and utilize tribal customary law. In response, I argue that as tribes enter the next fifty years of treaty rights implementation that the presumption of primary management should …

N-Methyl-D-Aspartate Receptor Antibody And Sensory Gating Deficits In Non-Smoking, Minimal Antipsychotic Medication Exposure, And First-Episode Patients With Schizophrenia, Jinghui Tong, Kebing Yang, Wei Li, Leilei Wang, Yi Yin, Yanfang Zhou, Junchao Huang, Ping Zhang, Yanli Zhao, Song Chen, Hongzhen Fan, Yimin Cui, Xingguang Luo, Shuping Tan, Zhiren Wang, Wei Feng, Baopeng Tian, Chiang-Shan R Li, L Elliot Hong, Yunlong Tan

Faculty, Staff and Student Publications

Background and hypothesis: Sensory gating deficit is considered a pathophysiological feature of schizophrenia, which has been linked to N-methyl-d-aspartate receptor (NMDAR) hypofunction as one of the potential underlying mechanisms. Here, we hypothesize that higher levels of NMDAR antibody (Ab) may contribute to the sensory gating deficits in schizophrenia.

Study design: We enrolled 72 non-smoking inpatients with first-episode schizophrenia (FES), most of them with only a relatively short duration of exposure to antipsychotic medications, and 51 non-smoking healthy controls (HC). Sensory gating was measured by P50 evoked potentials ratio and the difference between the two stimuli in an auditory paired-stimuli paradigm …

Domain-Adaptive Diagnosis Of Lewy Body Disease With Transferability Aware Transformer, Xiaowei Yu, Jing Zhang, Tong Chen, Yan Zhuang, Minheng Chen, Chao Cao, Yanjun Lyu, Lu Zhang, Li Su, Tianming Liu, Dajiang Zhu

Computer Science Faculty Research & Creative Works

Lewy Body Disease (LBD) is a common yet understudied form of dementia that imposes a significant burden on public health. It shares clinical similarities with Alzheimer’s disease (AD), as both progress through stages of normal cognition, mild cognitive impairment, and dementia. A major obstacle in LBD diagnosis is data scarcity, which limits the effectiveness of deep learning. In contrast, AD datasets are more abundant, offering potential for knowledge transfer. However, LBD and AD data are typically collected from different sites using different machines and protocols, resulting in a distinct domain shift. To effectively leverage AD data while mitigating domain shift, …

The Logic Of The Revenge Tax, Wei Cui

All Faculty Publications

Wei Cui is a professor in the Peter A. Allard School of Law at the University of British Columbia. In this article, Cui argues that the One Big Beautiful Bill Act’s formerly proposed section 899, targeting “unfair” foreign taxes, was more sensible than many observers initially perceived, and that, if seen as a restrained deployment of U.S. market power, it represented a defensible and ultimately acceptable approach for addressing the undertaxed profits rule and digital services taxes.

Anion Exchange Membrane Durability For Electrochemical Co2 Reduction In Membrane Electrode Assembly Cells, Soundarzo Tasnim

LSU Master's Theses

The electrochemical reduction of CO₂ using membrane electrode assembly (MEA) cells has emerged as a promising approach for carbon capture and conversion into valuable products. This study investigates the degradation mechanisms of anion exchange membranes (AEMs) in CO₂ reduction applications, focusing on Sustainion X37-50, PiperION, and FAA-3-50. The research analyzes the impact of chemical and mechanical degradation on membrane performance, highlighting key stability challenges in long-term operation. Fourier transform infrared spectroscopy (FTIR) and electrochemical impedance spectroscopy (EIS) were employed to monitor functional group stability and ionic conductivity loss over extended operation. The results indicate that hydroxide-induced degradation leads to nucleophilic …

Exploring The Validity Of Vocabulary Assessments In Racially, Dialectically, And Socioeconomically Diverse Preschool Populations, Lauren Betzer

LSU Master's Theses

Recent research has advocated for interactive assessments of vocabulary over more traditional, static assessments, as interactive assessments are more sensitive to linguistic and cultural diversity. Static vocabulary assessments, such as the Peabody Picture Vocabulary Test (PPVT), probe existing knowledge, while interactive assessments, such as the Quick Interactive Language Screener (QUILS), examines a child’s language in a wholistic manner by assessing previously learned vocabulary knowledge, syntactic knowledge, and processing when learning a new concept. It remains unclear which assessment more accurately captures children's vocabulary knowledge throughout the Deep South—a region characterized by its unique cultural and linguistic environment, which includes the …

Consideration Of Patient Phenotypes In Geographic Atrophy Due To Age-Related Macular Degeneration, Rishi P Singh, Christina Y Weng, John W Kitchens, Jaclyn Quilantan, Roy Schwartz, Caroline R Baumal, Roger A Goldberg

Faculty, Staff and Students Publications

Geographic atrophy (GA) is a form of advanced age-related macular degeneration (AMD) affecting approximately 1 million people in the USA and 5 million globally. In this review, retinal imaging techniques used for diagnosis and monitoring progression of GA in AMD, and the risk factors associated with the development and progression of GA are summarised. To familiarise clinicians with common phenotypes of patients with GA, the clinical and imaging features that may lead to rapid progression of GA in various phenotypes are highlighted. With the recent US Food and Drug Administration approval of new GA treatments that reduce lesion growth, understanding …

Retinal Ganglion Cell Migration And Viability Requires The Kinase Lkb1, Robert D Mackin, Ritika V Bhalla, Viktor Akhanov, Qudrat T Abdulwahab, Courtney A Burger, Melanie A Samuel

Faculty, Staff and Students Publications

The arrangement of neurons into ordered layers underlies circuit function in many nervous system regions. This is particularly true in the mammalian retina. Here, fate-committed retinal ganglion cells (RGCs) migrate from the apical to the inner retina, where they form connections that enable vision. The mechanisms that permit ganglion cell migration and whether distinct ganglion cell types use different migration modes are unknown. We show that the serine/threonine kinase LKB1 regulates ganglion cell migration and nuclear positioning. In the absence of LKB1, many ganglion cells remain in the apical retina. Misplaced cells show modified morphologies and display altered cytoskeletal proteins. …

Exploring System Identification Of Non-Linear Dynamics Using The Weighted Composition Operator And The Liouville Operator, Chukwuebuka Amagwula

USF Tampa Graduate Theses and Dissertations

System identification is the process of determining mathematical models that describe the dynamics of a system from data. Dynamic Mode Decomposition (DMD) and Sparse Identification of Nonlinear Dynamical Systems (SINDy) are two distinct approaches used for this purpose.

DMD identifies dominant spatiotemporal modes and eigenvalues that describe the evo lution of a system. It assumes a near-linear representation of dynamics and is closely linked to the Koopman operator, making it ideal for analyzing fluid flows, oscillatory systems, and modal structures. The DMD method uses time series data where each data point is referred to as a snapshot and represents the …

Loss Of Intracellular Fgf14 (Ifgf14) Increases Excitability Of Mature Hippocampal Pyramidal Neurons, Joseph L Ransdell, Yarimar Carrasquillo, Marie K Bosch, Rebecca L Mellor, David M Ornitz, Jeanne M Nerbonne

2020-Current year OA Pubs

Mutations in FGF14, which encodes intracellular fibroblast growth factor 14 (iFGF14), have been linked to spinocerebellar ataxia type 27 (SCA27), a multisystem disorder associated with deficits in motor coordination and cognitive function. Mice lacking iFGF14 (Fgf14-/-) display similar phenotypes, and we have previously shown that the deficits in motor coordination reflect reduced excitability of cerebellar Purkinje neurons, owing to a hyperpolarizing shift in the voltage-dependence of voltage-gated Na+ (Nav) current steady-state inactivation. Here, we present the results of experiments designed to test the hypothesis that loss of iFGF14 also attenuates the intrinsic excitability of mature hippocampal pyramidal neurons. Current-clamp recordings …

Disruption Of A Side Portal Pathway Permits Closed-State Inactivation By Bk Β Subunit N Termini, Yu Zhou, Xiao-Ming Xia, Christopher J Lingle

2020-Current year OA Pubs

Cytosolic N termini of several BK channel β regulatory subunits mediate rapid inactivation. However, in contrast to Kv channels, inactivation does not occur via a simple, open-channel block mechanism, but involves two steps, an association step in which ion permeation is maintained (O*), then followed by inactivation (I). To produce inactivation, BK β subunit N termini enter the central cavity through a lateral entry pathway ("side portal") separating the transmembrane pore-gate domain and cytosolic gating ring. Comparison of BK conformations reveals an aqueous pathway into the central cavity in the open structure, while in the closed structure, three sequential basic …

Highly Sensitive In Vivo Detection Of Dynamic Changes In Enkephalins Following Acute Stress In Mice, Marwa O Mikati, Petra Erdmann-Gilmore, Rose Connors, Sineadh M Conway, Jim Malone, Justin Woods, Robert W Sprung, Reid R Townsend, Ream Al-Hasani

2020-Current year OA Pubs

Enkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity. To begin to address this, we previously developed a system combining in vivo optogenetics with microdialysis and a highly sensitive mass spectrometry-based assay to measure opioid peptide release in freely moving rodents (Al-Hasani et al., 2018, eLife). Here, we show improved detection resolution and stabilization of enkephalin detection, which allowed us to investigate enkephalin release during acute stress. We present an analytical method for real-time, simultaneous detection of Met- and Leu-enkephalin (Met-Enk …

Subject Index, 12 Months Ended May 1982, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tax Trends, E. S. Linett

Tax Adviser

No abstract provided.

Washington Report: Tax Division Comments On Taxpayer Compliance Improvement Act Of 1982, Kenneth F. Thomas, Robert E. Clayton, American Institute Of Certified Public Accountants. Federal Tax Division

Tax Adviser

No abstract provided.