Digital Commons Network^™

Racialised Gradients Of Human Value And Marx’S Working Day, Today, Anthony F. Peressini

Philosophy Faculty Research and Publications

This paper reconsiders the ‘working day’ discussion in chapter ten of Capital and how it centres two parameters in the generation and appropriation of surplus value. The first parameter is the cost of labour-power paid by the capitalist and the second is the time that the worker must yield to the capitalist: the ‘length of the working day’. The first parameter represents the amount of pay required to keep the worker alive and able to work. Marx understood it as a lower limit below which capitalism would cease to function. This paper argues that, while analytically coherent, this understanding of …

Design And Verification Of A Reconfigurable Cryptographic Hardware Accelerator, Nicholas Merante

Theses

Cryptographic operations are used throughout computing systems to protect data confidentiality and integrity. Although software implementations provide flexibility, dedicated hardware can offer more predictable execution time and reduce the processing burden placed on a general-purpose processor. This thesis presents the design and verification of a Reconfigurable Cryptographic Hardware Accelerator (RCHA) that integrates AES-128, ChaCha20, SHA-256, and BLAKE2s within a single Verilog/SystemVerilog design. A top-level interface shared by the four cores manages algorithm selection, inputs, outputs, status, protocol errors, cycle measurement, and known-answer self-tests. Verification combined primitive-level tests, integrated UVM regressions, randomized stimulus, directed coverage tests, and OpenSSL-based C++ reference models …

Asynchronous Methods For Reducing Dynamic Power In Sparse Systems, Braley Lachner

Theses

While a strong history of computer development has maximized architecture performance, modern computing is fundamentally constrained by thermal limits and power consumption. This is especially true in power sensitive edge applications, which often have low activity. Asynchronous architectures offer a pathway to take advantage of sparsity within hardware to drastically reduce dynamic power through fine-grain selective activation of only necessary hardware. Despite these advantages, the semiconductor industry relies heavily on Electronic Design Automation (EDA) toolchains, which have been developed with many synchronous assumptions. The traditional overhead and strict incompatibility with standard EDA toolchains have limited adoption of asynchronous technologies in …

Design Of A Continuum Robot Test Bed Utilizing Model-Free Sliding Mode Control, Joseph Paul Streib

Theses

Continuum robots are a class of continually deformable robots inspired by snakes and tentacles that are commonly used in medical, search and rescue, and exploration applications. The robots are highly nonlinear and difficult to accurately model and control. Precise control of the pose of a continuum robot is typically reliant upon a system model. This work introduces a novel model free control algorithm for continuum robots that only relies upon the robot’s position in task space. The derived controller is built upon the foundation of a preexisting model free sliding mode controller and the q-state parameterized piecewise constant curvature kinematic …

Poppies In Bloom: Gathering Galaxies From Jwst Parallel Fields, Anika Kumar

Theses

A major goal of extragalactic astrophysics is connecting the Big Bang to the present by under- standing the evolution of star formation (SF) across cosmic time. The correlation between SF and the stellar mass buildup in galaxies, or the star forming main sequence relation (SFMS), highlights the various mechanisms that drive galaxy evolution. Deviations like quiescent galaxies, which have ceased forming stars, and starburst galaxies, which undergo an exceptionally high rate of SF compared to their normal star formation histories (SFH), offer key clues to the catalysts of galaxy evolution (e.g., mergers, gas accretion, supernovae feedback). Our understanding of early …

Uvm Verification Of A 4-Stage Asynchronous Risc-V Processor, Yashaswini Suresha

Theses

Functional verification often takes more effort than designing the system itself, especially when the design departs from the synchronous, globally clocked style that verification tools assume. Asynchronous or clockless circuits are an example of this. They use local request and acknowledge handshaking instead of a global clock, which reduces dynamic power and eliminates clock-distribution and skew problems. However, this also means that standard verification methods that rely on a single periodic clock no longer apply. This thesis introduces a constrained-random, coverage-driven verification environment for a four-stage asynchronous RISC-V processor. The environment is built in SystemVerilog using the Universal Verification Methodology …

Characterizing Heavy Water Displacement In Molecular Sieve Drying Beds For Practical Trace Tritium Capture Methods, Brandon M. Massett

Theses

Tritium plays a crucial role in nuclear fusion power plant designs, and adsorption beds are essential tools for managing tritiated water vapor. A series of tests was performed to investigate whether a saturated adsorption bed preferentially adsorbs heavy water vapor. The design of passive tritium control systems could potentially rely on adsorption beds preferentially trapping heavier isotopologues of water. This work investigates the displacement phenomenon and the effects of carrier gas superficial velocity on bed performance. Significant displacement was observed when a humid stream containing heavy water was diverted through a bed pre-saturated with light water, as indicated by changes …

Semiconductor Laser Calibration Through Photonic Chip With Microcontroller Driven Wavelength Inference, Clayton Acheson

Theses

Integrated Silicon Photonics leverages light-speed operation with lower power and higher data rates than electronic counterparts. To achieve this, light is sent through a silicon circuit, where it is manipulated to perform various operations. Primarily, the light for these circuits comes from laser sources. Semiconductor lasers are typically used for their small form factor and ability to be heterogeneously integrated into larger, more complex systems. Because the optical phase and wavelength of light respond to minute changes in local refractive index, light is increasingly used for high-sensitivity sensing in integrated photonic circuit applications. As such, schemes that integrate the laser …

Passive House Envelope Retrofit For Heritage Buildings In Hot Semi-Arid Climates: A Shoebox Energy Simulation Study Of The Former British Residency (Osmania University College For Women), Hyderabad, India, Hasini Kadaru

Theses

This study assesses interior-oriented envelope retrofits based on Passive House principles, applied to the British Residency of Hyderabad, now called Telangana Mahila Viswa Vidyalayam since 2022, and to Osmania University College for Women (OUCW) for the prior 70 years. This Grade 1-listed building was constructed in several phases starting in the 1790s, then remodeled and extended under Resident James Achilles Kirkpatrick from 1798 to 1805 and completed around 1808. It served as the Residency until 1947, when it was handed over to Osmania University.    Due to the conservation approach applied to the site, which does not allow any external changes, …

What Representations Preserve: Information-Theoretic And Geometric Conditions For Out-Of-Distribution And Hallucination Detection, Hong Yang

Theses

Models deployed outside controlled settings encounter inputs unlike their training data and may generate outputs unsupported by what they learned. A reliable system should recognize these cases. Out-of-distribution detection and hallucination detection are usually studied separately, but both depend on the same condition: the model's representation must retain the information that distinguishes an anomalous case from an ordinary one. If training never captures that information, or later suppresses it, no downstream detector can recover it. We study this condition from two complementary perspectives. Mutual information measures how much information about the relevant distinction remains in a representation, while feature-space geometry …

A Best-Practice And Risk-Assessment Framework For Auditable Ai Integration In Uae Government Socs, Nasser Hassan Nasser Abdulrazaq Alrazooqi

Theses

The growing use of artificial intelligence and generative AI in security operations centres  have the ability to improve alert triage, investigation, threat-intelligence enrichment,  and incident response. It also introduces governance risks including explainability, data  leakage, prompt injection, model lifecycle management, human oversight, and the  traceability of AI-assisted decisions. This study has developed a best-practice and risk assessment framework for the auditable integration of AI in UAE’s governmental SOCs.  The research follows a qualitative and practitioner-informed documentary analysis.  Publicly available UAE cybersecurity policies, internationally recognised NIST and  ISO/IEC standards, academic literature, industry guidance and compliance  publications were reviewed. Moreover, they were …

Modeling Active Galactic Nuclei Spectra Of Supermassive To Hypermassive Black Holes, Priti Finavia

Theses

It is generally believed that most massive galaxies host supermassive black holes (SMBHs) at their centers, with masses ranging from 10^6 -10^{10} M☉. During phases of rapid accretion, these SMBHs emit electromagnetic radiation across the entire spectrum, resulting in luminous active galactic nuclei (AGN). An open question is whether SMBHs can grow to exceed 10^{10} M☉ through continued accretion and successive mergers, potentially forming hypermassive black holes (HMBHs).  The broad line region (BLR) consists of dense gas clouds located within sub-parsec distances of the central SMBH. The clouds are photoionized by continuum radiation emitted by the accretion disk and hot …

Detecting Eccentric Kozai–Lidov Imprints On Gravitational Waves From An Intermediate–Stellar-Mass Binary Black Hole Around A Supermassive Black Hole, Zainab Mangi

Theses

The gravitational-wave signal of a compact binary carries the imprint of its environment. In a galactic nucleus, the tidal field of the central supermassive black hole (SMBH) drives Kozai--Lidov (KL) oscillations in the eccentricity of an orbiting binary, modulating the emitted signal. As a proof of concept, previous work showed that for an IMBH--stellar-mass black hole binary, this modulation is detectable with LISA out to about a megaparsec (Deme et al. 2020). This detectability depends on the parameters of the triple; among them, the outer eccentricity plays a special role: it switches on the octupole order of the secular approximation, …

Population Inference Of Compact Binaries With Eccentricity, Muhammad Zeeshan

Theses

Gravitational waves opened a new window to study the properties of compact binary systems, providing insights into their astrophysical formation and evolution. Initially, population studies relied on mass and spin distributions to distinguish between isolated, dynamical, and hierarchical merger channels; however, orbital eccentricity offers a complementary probe of binary formation scenarios. Historically, eccentricity received limited attention due to the lack of eccentric wave- form models and the absence of strong observational evidence within the LIGO–Virgo–KAGRA sensitivity band. A growing catalog, recent advances in eccentric waveform modeling, and analyses reporting candidates consistent with non-zero eccentricity motivate a systematic population-level study with …

Storm Surge And Tides In Convergent Estuaries: The Case Of Extratropical Storm Merbok In Alaska, Steven Dykstra, Stefan Talke, David A. Jay, Matthew Lobo, Silvia Innocenti, Pascal Matte

Civil and Environmental Engineering Faculty Publications and Presentations

Coastal floods are composed of multiple drivers that interact with coastline geometries and are difficult to differentiate. To investigate the effects of basin shapes on storm surge and tides, we study the landfall of ex-Typhoon Merbok in the east Bering Sea, Alaska. Water levels at 34 stations are detided with a new tide wavelet tool, CWT_Multi (Lobo et al., 2024), and the spatial and temporal shifts in tides and surge are interpreted via long-wave theory. Results show nonstationary semiannual trends in tidal constituents due to ice effects and large interannual variability in mean-sea level (20-40 cm). After removing non-stationary tidal …

What Drives Blockchain Technology Adoption? A Meta-Analysis Across Tam, Tpb, And Utaut Frameworks, Amir Rahmani, Roohollah Ahmadi, Tugrul Unsal Daim, Mehdi Zamani, Dilek Ozdemir

Engineering and Technology Management Faculty Publications and Presentations

Research on blockchain adoption has expanded rapidly, with most studies conceptualizing adoption as behavioural intention. Technology adoption models, such as the Technology Acceptance Model (TAM), the Theory of Planned Behavior (TPB), and the Unified Theory of Acceptance and Use of Technology (UTAUT), are commonly applied to explore blockchain technology adoption (BTA). However, empirical results from the 12 hypotheses associated with these models remain fragmented and, at times, inconsistent, with limited comprehensive quantitative integration. To address this gap, the present study performs a meta-analysis to evaluate the degree and direction of these hypotheses systematically. In accordance with PRISMA guidelines, 149 quantitative …

Decision-Making Criteria In Polygenic Embryo Screening: A Survey Of Reproductive Medicine Physicians, Rémy A Furrer, Aayushi Gandhi, Dorit Barlevy, Shai Carmi, Todd Lencz, Stacey Pereira, Gabriel Lázaro-Muñoz

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Polygenic embryo screening (PES) examines embryos for their genetic likelihood of developing complex conditions and traits. The commercialization of PES places reproductive endocrinologists and infertility specialists (REIs) as the primary decision-makers in its use, despite professional guidelines cautioning that PES is not ready for clinical use.

Methods: This survey examines how 152 US REIs perceive and approach potential clinical decision-making scenarios regarding the use of PES.

Results: REIs were more likely to offer PES for medical conditions (up to 62% for cancer) than for traits (eg, 0% for skin color, 10% for body mass index). When evaluating 11 potential …

City Farm Slo - Market Stand Modernization, Juan Diaz

Construction Management

This paper analyzes the design, planning, and buildout of a custom multi-level stand, farm signage, and supporting equipment for the non-profit organization City Farm SLO. The overall goal of the project was to provide the farm with a modernized and functional market space. The project first addressed any owner design requirements, the approval of materials lists, and the assessment of existing conditions. The pre-construction consisted of developed drawings, materials lists, cost estimates, and a project schedule. Aside from setting up requirements, the owner provided specific milestones to be achieved during the construction phase of the project. A major risk found …

Diabetter Together: Outcomes Of A Randomized Controlled Trial Evaluating A Peer Mentor Behavioral Intervention For Young Adults With Type 1 Diabetes During The Transfer From Pediatric To Adult Care, Marisa E Hilliard, Charles G Minard, Samantha A Carreon, Wendy L Levy, Sarah K Lyons, Randi Streisand, Tricia S Tang, Siripoom V Mckay, Sridevi Devaraj, Barbara J Anderson

Faculty, Staff and Students Publications

Objective: Transition between pediatric and adult health care is complex, with high risk for loss to follow-up and suboptimal health outcomes for young adults with type 1 diabetes. This trial evaluated the efficacy of DiaBetter Together, a 12-month strengths-based behavioral intervention delivered by trained peer mentors. The intervention aimed to help young adults navigate the transfer process to promote optimal glycemic outcomes, shorten time to adult care follow-up, and improve psychosocial outcomes.

Research design and methods: Using a single-site randomized clinical trial design, we compared the 12-month intervention to usual care among n = 100 young adults aged 17-25 years …

Quantitative Imaging Of Pyruvate Metabolism In A Patient With Anaplastic Thyroid Cancer, James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B Peterson, Clifton D Fuller, Vlad C Sandulache, Stephen Y Lai

Faculty, Staff and Students Publications

Purpose: Magnetic resonance imaging using hyperpolarized (HP) [1-13C]-pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi-quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular metabolism. A validated pharmacokinetic (PK) model for analysis of intracellular pyruvate metabolism is needed to enhance the accuracy of quantitative metrics and clinical translation of metabolic MRI using HP pyruvate.

Methods: A PK model with two physical compartments and two chemical pools was developed to analyze the conversion of labeled pyruvate into lactate in vitro. …

Colocalization Of Eqtls With Type 2 Diabetes And Glycemic Traits Using Whole-Genome Sequences In Diverse Populations From The Nhlbi Trans-Omics In Precision Medicine (Topmed) Program, Ningyuan Wang, Daniel A Dicorpo, Yixin Zhang, Erica Kleinbrink, Donna K Arnett, John Barnard, John Blangero, Donald W Bowden, April P Carson, Yii-Der Ida Chen, Mina K Chung, Joanne E Curran, Dawood Darbar, Ravindranath Duggirala, Patrick T Ellinor, Diane Fatkin, Myriam Fornage, Nancy Heard-Costa, Jiang He, Lifang Hou, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, David D Mcmanus, Braxton D Mitchell, Ryan L Minster, Kari E North, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Moore B Shoemaker, Jonathan D Smith, David R Van Wagoner, Francois Aguet, Kristin Ardlie, Joshua C Bis, Jennifer A Brody, Brian E Cade, Clary B Clish, Paul S De Vries, James S Floyd, Barry I Freedman, Stacey Gabriel, Robert E Gerzsten, Mark O Goodarzi, Charles Gu, Xiuqing Guo, Namrata Gupta, Susan R Heckbert, Sarah Hsu, Yi-Jen Hung, Rita R Kalyani, Tanika N Kelly, Gregory L Kinney, Changwei Li, Simin Liu, Yongmei Liu, Donald M Lloyd-Jones, Joann E Manson, Rasika A Mathias, Josep M Mercader, Alanna C Morrison, Take Naseri, Suna Onengut, Nicholette D Palmer, Patricia A Peyser, Qibin Qi, Sridharan Raghavan, Alex P Reiner, Mary R Rooney, Magdalena Sevilla-Gonzalez, Chloe Sarnowski, Joshua D Smith, Jennifer A Smith, Nicole L Spartano, Usman Tahir, Kent D Taylor, Deirdre K Tobias, Russel P Tracy, Satupa'itea Viali, Heming Wang, Alexis C Wood, Lisa R Yanek, Wei Zhao, Yinan Zheng, Josée Dupuis, Ching-Ti Liu, Robert Sladek, Jennifer Wessel, James B Meigs, Alisa K Manning, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium

Faculty, Staff and Students Publications

Large-scale multiancestry genome-wide association studies have identified hundreds of loci associated with type 2 diabetes (T2D) and glycemic traits, yet imputed genotyping arrays limit the detection of low-frequency and rare variants. Whole-genome sequencing (WGS) offers a more complete view of genetic variation, especially across diverse populations. We analyzed high-coverage (38×) WGS data from 21,913 T2D case subjects, 61,036 control subjects, and up to 50,011 individuals with no diabetes with fasting glucose, fasting insulin, and HbA1c from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Program. We performed single-variant association testing, conditional analysis, fine-mapping, and Bayesian colocalization to …

Proteomic Signatures Of 3-Year Progression From Impaired Fasting Glucose To Diabetes: The Atherosclerosis Risk In Communities (Aric) Study, Mary R Rooney, Justin B Echouffo Tcheugui, Jingsha Chen, Keenan A Walker, Christie M Ballantyne, Eric Boerwinkle, Tanika N Kelly, Chiadi E Ndumele, James S Pankow, Morgan E Grams, Wendy S Post, Peter J Ganz, Alexis C Wood, Jerome I Rotter, Elizabeth Selvin, Josef Coresh

Faculty, Staff and Students Publications

Objective: To identify proteomic signatures underlying 3-year progression from impaired fasting glucose (IFG) to diabetes.

Research design and methods: We examined IFG progression in the Atherosclerosis Risk in Communities (ARIC) study from visit 2 (1990-1992) to visit 3 (1993-1995). We tested associations of 4,955 plasma proteins (SomaScan version 4.0) with ∼3-year progression from IFG (FG 100-125 mg/dL without diabetes) to diabetes (diagnosis, medication, or FG ≥126 mg/dL) using logistic regression models adjusted for demographics, cardiometabolic risk factors, and baseline glucose with Bonferroni correction (P < 10-5). We explored biological pathways enriched among the top proteins and calculated improvements in prediction (ΔAUC and net reclassification using 3-year risk thresholds of 6% and 15% in 80% training and 20% internal validation subsamples). We validated results in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.

Results: There were 3,786 ARIC participants with IFG (mean [SD] age 57 [6] years, 52% female, …

De Novo Complex Genomic Rearrangement Spanning 2q31.1 In A Proband With Congenital Malformations: Genotype-Phenotype Correlation And Development Of A Cgr Detection Pipeline, Katherine Helle, Jesse D Bengtsson, Mira Gandhi, Christopher M Grochowski, Ming Yin Lun, Neha Sudhir, Shalini N Jhangiani, Fritz J Sedlazeck, Seema R Lalani, Neil A Hanchard, Claudia M B Carvalho

Faculty, Staff and Students Publications

The 2q31 region is commonly associated with pathogenic alleles of the HOXD cluster leading to various clinical phenotypes related to skeletal development. We present a proband with tetralogy of Fallot and multiple congenital anomalies. Genomic variant screening including an in-house CGR detection pipeline pairing genome sequencing (GS) structural variant calls with read-depth data revealed a de novo complex genomic rearrangement (CGR) spanning 2.7 Mb across 2q31 characterized by a series of duplications and triplications including the HOXD gene cluster. The genomic structure was assembled by applying combined methodologies including short-read and long-read GS, and optical genome mapping (OGM). This in-house …

Transformer La Santé Et Les Droits Sexuels Et Reproductifs Des Adolescentes En Afrique De L’Ouest Et Du Centre, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian

Adolescents and Young People

La série « L’avenir des filles en point de mire : données probantes d’Afrique de l’Ouest et du Centre » examine les défis auxquels font face les adolescentes de la région et met en lumière des approches éclairées par les données probantes pour améliorer leurs conditions de vie. La série couvre huit pays répartis entre le Sahel, l’Afrique de l’Ouest côtière et l’Afrique centrale, représentatifs d’une diversité de contextes de fragilité, de conflit et de développement, ce qui permet aux constats du GIRL Center de refléter les expériences à la fois diverses et cumulées des adolescentes à travers la région …

Lessons From The Club Homeschool Capstone: Testing, Data Discipline, And The Computer Science Curriculum, Shane Brown

University Honors Theses

This thesis looks at the CLUB Homeschool Capstone project to argue that Portland State University's Computer Science curriculum should introduce testing and data quality discipline earlier and more intentionally than it does now. As team lead of a seven-person team, I coordinated sprint planning, communicated with the sponsor, and developed custom Discourse plugins that enhanced an existing forum platform instead of creating a separate application database, as requested by the sponsor. The project's requirements document called for a formal testing plan, but our team lacked the practical experience to implement one. This gap became evident through my internships as a …

Impact Of Prematurity On Nutrient Signaling And Protein Synthesis In Skeletal Muscle, Antonio C Ramos Dos Santos, Ki Beom Jang, Marta L Fiorotto, Teresa A Davis

Faculty, Staff and Students Publications

Preterm birth disrupts nutrient-responsive signaling pathways critical for skeletal muscle growth and long-term metabolic health. Despite improvements in neonatal care, preterm infants often experience postnatal growth failure marked by impaired lean mass accretion. This review examines how prematurity intrinsically alters insulin and amino acid signaling to mechanistic target of rapamycin complex 1 (mTORC1), a central regulator of translation initiation and protein synthesis. Evidence from translational models reveals blunted activation of mTORC1 and its downstream effectors, independent of birth weight or comorbidities. Defects in insulin-PDK1/mTORC2-Akt signaling and amino acid sensing, particularly leucine sensing, contribute to impaired mTORC1-dependent translation initiation and reduced …

“We Want To Make You A Better Man”: African American Men With Dual Membership In Black Greek Letter Organizations And Prince Hall Masonic Lodges, Lakesha Rae Denton

All-Inclusive List of Electronic Theses and Dissertations

This dissertation examines the rationale and experiences of Black men who have initial membership within a black Greek letter organization as an undergraduate, who also join Masonic Lodges. The study was guided by one research question: 1) what the rationale is pertaining to Black men, who are initially members of Black Greek letter organizations as an undergraduate, that also join a Masonic lodge, therefore granting them dual membership status. The study was important because the value of BGLO’s has declined due to hazing and lack of leadership and guidance. Black men are not being developed as they should and while …

Reconstructing Stand-Age Structure In A Wet Miombo Woodland Using Dendrochronology, Zambia, Clara Tiyembekeze Zulu

All-Inclusive List of Electronic Theses and Dissertations

Dendrochronological research in tropical Africa has remained limited, leaving critical gaps in stand-age structure and climate-growth relationships in seasonally dry tropical woodlands. This study reconstructed stand-age structure and assessed climate sensitivity in the wet Miombo woodland of African Explosives Limited (AEL) forest, Copperbelt Province, Zambia. Field sampling was conducted during four African Dendrochronology Fieldschools (2021-2024) using a Modified Variable Area Transect (MVAT) design across nine plots. The series intercorrelation was 0.351; the average mean sensitivity was 0.423. The oldest tree was 170 years old, and more than 70% of the sampled species showed potential for dendrochronology. Markhamia obtusifolia was the …

Neurotypical And Neurodivergent Traits As Predictors Of Memory Performance, Maranda N. Willis

Electronic Theses and Dissertations

Traits associated with autism spectrum disorder (ASD) have been observed within neurotypical populations to influence a range of cognitive and behavioral characteristics, including attention to detail and the need for cognition (NC). The present study assessed traits commonly associated with ASD with the 42-item Comprehensive Autistic Trait Inventory (CATI) for 111 participants. The relations between ASD-like traits, attention to detail, as afforded by the Minnesota Clerical Aptitude Test (MCT), and memory, as measured by vignettes, were examined. Memory performance was assessed using 12 multiple-choice questions on vignette details. Participants read one of three randomly assigned 25-sentence vignettes of varying themes …

Sez6-Targeting Antibody-Drug Conjugate Abbv-706 In Advanced Small Cell Lung Cancer And Solid Tumors: A Phase 1 Trial, Lauren Averett Byers, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

Seizure-related homolog 6 (SEZ6) is expressed in small cell lung cancer (SCLC) and neuroendocrine neoplasms. In an open label, phase 1 trial, ABBV-706, an antibody-drug conjugate with a SEZ6-directed antibody linked to topoisomerase-1 inhibitor (Top1i), was administered intravenously every 3 weeks (Q3W) to 288 patients with advanced solid tumors; 240 received monotherapy, including 124 with relapsed/refractory (R/R) SCLC. Primary objectives of dose escalation (part 1, advanced solid tumors), dose optimization and expansion (part 2, R/R SCLC only) and dose expansion (part 4, central nervous system tumors and high-grade neuroendocrine neoplasms only) were to evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity …