Digital Commons Network^™

Physical Activity And Molecular Subtypes Of Colorectal Cancer: A Pooled Observational Analysis And Mendelian Randomization Study, Christos V Chalitsios, Yin Cao, Et Al.

2020-Current year OA Pubs

BACKGROUND: Physical activity is associated with lower colorectal cancer (CRC) risk, but its association with molecular subtypes defined by genetic and epigenetic alterations of the disease is unclear. Such information may enhance the understanding of the mechanisms related to the benefits of physical activity.

METHODS: Pooled observational (cases: n = 5386; controls: n = 6798; studies n = 5) and genome-wide association data (cases: n = 8178; controls: n = 10 472; studies n = 5) were used. We used multivariable logistic regression models and Mendelian randomization to assess the association between physical activity and the risk of CRC subtypes …

National Alliance Of Sickle Cell Centers Consensus Recommendations On Sickle Cell Disease Health Maintenance: A Consensus Statement, Seethal A Jacob, Sana Saif-Ur-Rehman, Et Al.

2020-Current year OA Pubs

IMPORTANCE: The most common inherited blood disorder in the world, sickle cell disease (SCD) is a known global health concern. While survival of children into adulthood has improved significantly over the last few decades in high-resource countries, substantial gaps in care standards and limited practice harmonization persist.

OBJECTIVE: To provide up-to-date recommendations for preventive care and treatment of all people living with SCD and its related comorbidities.

EVIDENCE REVIEW: As part of the National Alliance of Sickle Cell Centers (NASCC), 41 pediatric and adult sickle cell disease experts developed consensus standards and recommendations based on available evidence and expert consensus …

Muscle Fatigue Arising Intrinsically From Sur2- But Not Kir6.1-Dependent Gain-Of-Function In Cantu Syndrome Mice, Rosa Scala, Maya Mukadam, Yuezhou Chen, Courtney Frazier, Nathaniel W York, Robert C Tryon, Gretchen A Meyer, Colin G Nichols

2020-Current year OA Pubs

Cantu syndrome (CS) is a rare disease caused by gain-of-function (GOF) mutations of Kir6.1 or SUR2 subunits of ATP-sensitive potassium (KATP) channels. CS patients with SUR2 and Kir6.1 variants display a similar constellation of symptoms, including muscle weakness and fatigue. The effects of CS mutations on skeletal muscle KATP channels, and any consequent direct effects on contractility, are currently unclear. Here, we used two knock-in mouse models of CS, respectively, carrying GOF mutations Kir6.1[V65M] or SUR2[A478V], to assess KATP channel properties and contractility in isolated fast-twitch extensor digitorum longus (EDL) and slow-twitch soleus (SOL) muscles. Electrophysiological recordings in isolated myofibers …

Pip2-Driven Cytoplasmic Domain Motions Are Coupled To Kir2 Channel Gating, Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G Nichols, Sun-Joo Lee

2020-Current year OA Pubs

Inwardly rectifying potassium (Kir) channel activity is important in the control of membrane potentials in both excitable and non-excitable cells and is regulated through various ligands, including specific membrane lipids. Phosphatidyl-4,5-bisphosphate (PIP2) is required for activity of all Kir channels, binding to the cytoplasmic domain in a compact conformation tightly tethered to the transmembrane domain. Most Kir2 channel structures determined in complex with PIP2 molecules are nevertheless in a closed state, requiring additional conformational changes for channel opening. We have carried out full atomistic MD simulations, which indicate PIP2-dependent conformational changes that are coupled to opening and closing of the …

Overexpression Of The Signaling Coordinator Gab2 Can Play An Important Role In Acute Myeloid Leukemia Progression, Michael H. Kramer, Stephanie N. Richardson, Yang Li, Tiankai Yin, Nichole M. Helton, Daniel R. George, Michelle Cai, Sai Mukund Ramakrishnan, Casey Ds Katerndahl, Christopher A. Miller, Timothy J. Ley

2020-Current year OA Pubs

Mutations that initiate acute myeloid leukemia (AML) can cause clonal expansion without transformation (clonal hematopoiesis). Cooperating mutations, usually in signaling genes, are needed to cause overt disease, but these may require a specific fitness state to be tolerated. Here, we show that nearly all AMLs arising in a mouse model expressing 2 common AML-initiating mutations (Dnmt3aR878H and Npm1cA) acquired a single copy amplification of chromosome 7 (chr7), followed by activating mutations in signaling genes. We show that overexpression of a single gene on chr7 (Gab2, which coordinates signaling pathways) was tolerated in the presence of the Npm1cA mutation, could accelerate …

Exploring Di College Coaches’ Perceptions Of Holistic Coaching And The Factors Impacting Their Ability To Succeed In The Current College Sports Landscape, Deborah V. Hogan Phd

Journal of Issues in Intercollegiate Athletics

In the highly competitive Division I (DI) college sports system, coaches are expected to produce winning programs while developing their college athletes holistically. Recent changes in NCAA policies complicate the coach-athlete relationship, hindering coaches' ability to serve as effective holistic leaders. This study uses grounded theory to understand how DI coaches in high-profile sports perceive their roles as holistic leaders and manage external challenges to provide holistic college athlete experiences. Semi-structured interviews with 12 football and women’s basketball coaches revealed five main themes: 1) coaches are educators, 2) strategies for holistic coaching, 3) supporting Black college athletes, 4) college sports …

Ncaa Division I Senior Athletic Administrators' Perceptions Of And Experiences With Mental Performance Consultants And Their Services: A Qualitative Investigation, Morgan R. Eckenrod, Rebecca Zakrajsek, Johannes Raabe

Journal of Issues in Intercollegiate Athletics

At the National Collegiate Athletic Association (NCAA) Division I (DI) level, senior athletic administrators (SAAs) play a critical role in hiring Mental Performance Consultants (MPCs). Researchers found that NCAA DI administrators generally believe MPCs are beneficial in helping student-athletes manage competition pressures and improve performance, the number of full-time MPCs in NCAA DI athletic departments is still limited. In this study, eleven NCAA DI SAAs with at least one full-time MPC in their athletic department that solely delivered mental performance services were interviewed about their perceptions of and experiences with MPCs and their services. Using reflexive thematic analysis procedures, three …

Investigating The Glass Cliff Phenomenon In Ncaa Division I Women’S Basketball, Nicholas Swim, Adam R Cocco, Meg Hancock, Nick Kopka

Journal of Issues in Intercollegiate Athletics

In 2022-2023, across all Division I women's college sports teams, women only held 42% of all head coaching positions. Women's college basketball represents one of the outlier sports, as almost 70% of their head coaches for NCAA Division I women's basketball teams were women. While women head coaches are well represented in women's college basketball, Gerretsen et al. (2023) suggest inconsistencies exist in past experience, tenure length, and gender perceptions in women's college basketball hiring practices. This study further aimed to investigate these inconsistencies utilizing role congruity theory and the glass cliff phenomenon. To investigate, the researchers collected data on …

Supporting The College Athlete Amidst The Onset Of Name, Image, And Likeness, Brennan K. Berg, Michael Hutchinson, Janelle E. Wells, David W. Walsh, Andre Simmond

Journal of Issues in Intercollegiate Athletics

Athletic administrators often assume a distinct stakeholder role that has the most immediate and frequent impact on college athletes’ well-being and retention. The implementation of name, image, and likeness (NIL) represents a historic transformation in college athletics. Utilizing a sport development framework, particularly the retention stage, to examine elite athlete development, how athletic administrators socially support college athletes in the new context of NIL and its impact on administrators’ work experiences were empirically assessed. Semi-structured interviews were conducted with 18 athletic administrators at nine universities. The themes of Implementation Challenges, Lack of Uniformity, Holistic Benefits to Athlete Well-Being, and Mostly …

The Impact Of Geographic And Community Diversity On The Transitionary Experiences Of International College Athletes, Marek Taškár, Chris Corr, Nicole Sellars, Sarah Stokowski, Karina Jolly, Trevor Bopp

Journal of Issues in Intercollegiate Athletics

International college athletes migrating to the United States for athletic competition encounter unique challenges such as language barriers, cultural adjustment, and familial detachment. These obstacles can hinder international college athletes’ transition compared to those of domestic athletes. While supportive programming and personnel have been illustrated to ease the transition and foster acculturation among international college athletes, the impact of the geographic location of an institution may impact the acculturation process for international college athletes. Given the importance of acculturation to athletic and academic success, this study examined how cultural diversity within communities hosting NCAA member institutions affects international college athletes’ …

The Influence Of False Memories On Eyewitness Testimony, Shay Kossen

Honors College Theses

This paper examines the role that false memories play in eyewitness testimony. Though eyewitness testimonies are a direct source of evidence regarding a crime, they are often flawed due to the malleable and reconstructive nature of memory, leading to many wrongful convictions. This review synthesizes previous research on false memories and eyewitness testimony to analyze the factors that contribute to inaccuracies in eyewitness testimony. This paper examines the origination of false memories, highlighting key factors such as the misinformation effect, source misattribution, and retention intervals. Additionally, this review analyzes factors from previous research that increase susceptibility to false memories, the …

25 Conference Program - Beneficiation Of Phosphates X, Patrick Zhang, Phong Vo, Erika Rova, André Carlos Silva, Ewan Wingate, Trong Dang-Vu

Beneficiation of Phosphates X

No abstract provided.

Moderators Of Peer Influence Effects For Adolescents’ Smoking And Vaping Norms And Outcomes In High And Middle-Income Settings, Jennifer M. Murray, Sharon C. Sánchez-Franco, Olga L. Sarmiento, Erik O. Kimbrough, Christopher Tate, Shannon C. Montgomery, Rajnish Kumar, Laura Dunne, Abhijit Ramalingam, Erin L. Krupka, Felipe Montes, Huiyu Zhou, Laurence Moore, Linda Bauld, Blanca Llorente, Frank Kee, Ruth F. Hunter

Economics Faculty Articles and Research

Background: Peer influence is central to adolescent smoking initiation, yet its impact varies depending on individual and contextual factors. Understanding which moderators (personality, contextual, cultural, and environmental traits) shape these processes can inform more effective prevention strategies. We investigated hypothesized moderators of peer influence for adolescent smoking/vaping norms and other smoking-related outcomes in high and low-middle-income countries (LMICs): Northern Ireland and Bogotá.

Methods: Across 12 schools (n = 1,344, age 12–13 years), participants completed novel behavioral economics experiments measuring social norms, and self-report surveys, before and after school-based prevention interventions (ASSIST and Dead Cool). We examined how peer influence …

Exploring Runtime Evolution In Android: A Cross-Version Analysis And Its Implications For Memory Forensics., Babangida Bappah

LSU Master's Theses

Userland memory forensics has become a critical component of smartphone investigations and incident response, enabling the recovery of volatile evidence such as deleted messages from end-to-end encrypted apps and cryptocurrency transactions. However, these forensics tools, particularly on Android, face significant challenges in adapting to different versions and maintaining reliability over time due to the constant evolution of low-level structures critical for evidence recovery and reconstruction. Structural changes, ranging from simple offset modifications to complete architectural redesigns, pose substantial maintenance and adaptability issues for forensic tools that rely on precise structure interpretation. Thus, this paper presents the first systematic study of …

Front Matter

Texas A&M Law Review

Front Matter.

The Role Of The Preamble: Evidence From The Constitutional Convention And The Ratification Debates, Stuart Ford

Texas A&M Law Review

This Article explores the role of the Preamble in constitutional interpretation by looking at how it was perceived at the founding. It does this in three ways. First, it explores how preambles were used in eighteenth-century America. At the time, preambles were almost universally understood to be key to interpreting the laws and constitutions they preceded. This shared understanding forms the backdrop against which the Preamble was received by the founding generation. Second, it looks at the records of the Constitutional Convention for evidence of what role the drafters expected the Preamble to serve. Unfortunately, the records of the Convention …

Causation’S Due Process Dimensions, Cassandra Burke Robertson, Charles W. “Rocky” Rhodes

Texas A&M Law Review

For decades, courts have grappled with the tension between compensating victims of mass harms and maintaining fairness to defendants when causation is difficult to prove. This Article argues that the Supreme Court’s due process jurisprudence provides a relevant framework for navigating this tension. We contend that the Court over the last three decades has established a consistent Fourteenth Amendment due process approach in punitive damages and personal jurisdiction cases, which is rooted in antecedents tracing to the nineteenth century and relies on a nexus of interests that balances individual rights, state interests, and federalism concerns. This framework, we argue, has …

That Old College Try: Judge-Made Monopolies In The Market For Affinity Goods, John A. Rothchild

Texas A&M Law Review

There is a large market for goods such as t-shirts, coffee mugs, posters, and baseball caps that are emblazoned with the names and symbols of culturally prominent institutions—universities, athletic teams, musical bands, automobile brands. We buy, wear, and display those goods to express our affinity with the referenced institution. The owners of the trade symbols that adorn these items, which this Article refers to as “affinity goods,” jealously guard what they claim is their sole right, under the trademark laws, to authorize the use of their symbols as decoration. They have brought numerous lawsuits aimed at establishing and enforcing this …

Thermtron: The Unsexy Case The Current Court Should Overturn (Statutory Stare Decisis Be Damned), Christine Tamer

Texas A&M Law Review

Since 1887, Congress has created an impenetrable dike wall to stop appellate review of remand orders in 28 U.S.C. § 1447(d), which provides: “An order remanding a case to the State court from which it was removed is not reviewable on appeal or otherwise . . . .” Then, in 1976, the Supreme Court held “that § 1447(d) does not mean what it says” and, thereby, punctured not a tiny hole, but a big one in Congress’s dike wall that had been impenetrable for nearly 90 years. While you won’t find Thermtron—an unsexy jurisdictional case—on any list of the …

Parenting Under Constraint: How Histories Of Abuse And Sexual Violence Shape Mothers' Caregiving In A Homeless Shelter, Kiera P. Irvin

Honors Program: Senior Projects (Public)

Background: Mothers experiencing homelessness often carry extensive trauma histories, yet little work examines how abuse and sexual violence shape day-to-day parenting inside communal shelter settings. This study explored how trauma histories intersect with shelter structures to influence caregiving and feelings surrounding parenting among homeless mothers.

Method: Using a qualitative design, four mothers (ages 30–51) residing in a large Midwestern homeless shelter completed approximately 30-minute, semi-structured interviews in a private room onsite. Data were audio-recorded, transcribed verbatim, and analyzed with inductive reflexive thematic analysis in Dedoose.

Results: Three interrelated themes were identified. (1) Parenting Under Constraint, in which communal living, limited …

Seeing What Matters: Safety-Critical Semantic Segmentation Via Transfer Learning On Construction Sites, Obiora J. Odugu

LSU Master's Theses

Autonomous robots are increasingly deployed on construction sites for tasks such as progress monitoring, inspection, and safety assessment. For these robots to operate effectively, they must perceive and interpret complex, dynamic environments populated by workers, machinery, and unstructured terrain. Achieving reliable perception depends on high performing semantic segmentation models trained on large volumes of annotated data—an expensive and logistically challenging requirement in construction due to privacy restrictions, variable site access, and slow digitalization. This research addresses the challenge of limited labeled data by investigating transfer learning as a label-efficient approach for construction-site segmentation. Specifically, it explores whether road construction imagery—abundant …

Exploring Perceptions Of High School Paraprofessionals Regarding Training On The Use Of Prompts When Implementing Transition Plans For High School Students With Autism Spectrum Disorder, Candace Galvez

Doctor of Education Program Dissertations

Paraprofessionals often assist teachers in providing instruction to students with autism spectrum disorder (ASD) and require training to help students achieve the goal of independence (Ledford et al., 2018). However, there is a lack of quality training among paraprofessionals when implementing evidence-based teaching practices (Jones & Zarcone, 2014). The problem explored is the lack of quality training paraprofessionals receive in the use of prompts when they implement transition plans for students with ASD (Brock, 2022). The purpose of this qualitative phenomenological study was to explore the lived experiences of high school paraprofessionals in New Jersey state-approved private schools related to …

Pause For Thought – Exploring Ai Error In The Assessment Of Industrial Sustainability Reports, Jake Mooney, Colm Tormey, Cillian Gleeson, Shane Hoban, Dylan Kirby, Christine Nangle

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

From Conflict To Connection: Educators Leading The Shift Towards Restorative Practices (Rp) In Deis Primary Schools, Ellen Slattery, Clara Hoyne

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

The Tax Adviser, Volume 2, Number 12, December 1971, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tax Trends, Harry Z. Garian

Tax Adviser

No abstract provided.

Estate Planning: Analyzing Life Insurance Policies, Edward S. Schlesinger

Tax Adviser

No abstract provided.

Tax Clinic, Thomas S. Oehring

Tax Adviser

No abstract provided.

Proposed Changes In The Taxation Of Advertising Income Of Exempt Organization Publications, John Ellicott

Tax Adviser

No abstract provided.

The Tax Adviser, Volume 2, Number 11, November 1971, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.