Digital Commons Network^™

Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3, Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner

2020-Current year OA Pubs

Genomic studies of neurodevelopmental disorders (NDDs) have identified several relevant genomic variants. EBF3 is a gene with an excess of protein-coding de novo variants and underlies Hypotonia, Ataxia, and Delayed Development Syndrome. We previously identified noncoding de novo variants in an enhancer of EBF3 and further found enrichment of deletions of this enhancer in NDDs. In this study, we generated a novel mouse line that deletes the highly conserved, orthologous mouse region within the Rr169617 regulatory region, and characterized the molecular and phenotypic aspects of this mouse model. We found a deviation from Mendelian expectation (P=0.02) with significant depletion of …

Evaluating Competencies In Counseling Students: Comparing Adjunct And Core Faculty Ratings, Mark D. Newmeyer, Kaitlyn C. Stafford, Peter J. Buckingham, Karen E. Fischer, Meredith D. Mcdaniel, Rhys P. Wilson

Journal of Counselor Preparation and Supervision

This study examines the differences in how adjunct and core faculty evaluate counseling students using a brief version of the Counselor Competencies Scale-Revised (CCS-R). Data from 647 evaluations of 433 students were analyzed. The results show that adjunct faculty, particularly those with master's degrees, tend to rate students significantly higher on professional counseling dispositions than core faculty, raising concerns about the consistency of gatekeeping in counselor training programs. These findings suggest a need for the standardization of counseling disposition evaluation practices to maintain high training standards. Implications for student-to-faculty ratio requirements are discussed.

Counselor Education: Digital Delivery With Confidence, Nicole Marie Arcuri-Sanders, Alisha Davis

Journal of Counselor Preparation and Supervision

Counselor education programs are required to demonstrate a clear framework, effective implementation, and overall program effectiveness. The pandemic’s surge in online instruction influenced CACREP’s (2024) digital delivery (DD) standards, addressing ethical and legal implications alongside student outcomes. Guidance from digital health initiatives, telemental health ethics and legal practices can be invaluable in clarifying DD protocols for counselor education programs. Understanding the parallels between DD and digital health regulations (e.g., HIPAA, ACA [2014], and NBCC [2023] ethical codes) provides a solid foundation for protecting both students and programs. Integrating technology and modeling digital health practices can enhance counselor education, benefiting both …

In Vivo Pharmacokinetic Evaluation Of A Gastro-Retentive Triple Drug Delivery System Utilizing Natural Polymers For Enhanced Helicobacter Pylori Eradication, Edukulla Satheesh Kumar, Hindustan Abdul Ahad, Thirumalesh Naik Sugali Banoth

Bulletin of Faculty of Pharmacy Cairo University

This study evaluates the in vivo pharmacokinetics of triple-drug gastro-retentive formulation (metronidazole- Plantago ovata seed mucilage/ clarithromycin- Abelmoschus esculentus fruit mucilage/enteric-coated pantoprazole) for Helicobacter pylori eradication, with a focus on pharmacokinetic parameters (e.g., relative bioavailability vs. conventional doses) as the true contribution. In a cross over study using six rabbits, plasma concentrations of metronidazole, clarithromycin, and pantoprazole sodium were measured via High Performance Liquid Chromatography technique, and pharmacokinetic parameters were determined. A single dose of the optimized formulation (C-8) produced optimal drug levels, with a mean Cmax of 24.36 ± 0.84 μg/mL and tmax at 6 hours. The other pharmacokinetic …

Evaluating Student Proficiency In Quantitative Reasoning, Gabriel Chavez, Jennifer Clinkenbeard, Tolga Tezcan, Celine Pinet, Jennifer Duggan, George Beckham, Sumadhur Shakya, Christina Zhang

Numeracy

Quantitative Reasoning (QR) competencies are increasingly vital for academic and professional success across disciplines. This study examines the QR proficiency of over 400 undergraduates through a mixed-methods approach, integrating survey-based self-assessments (n = 469) with direct evaluations of final exams (n = 80). This study took place at a public, primarily undergraduate, four-year state university in Northern California with approximate enrollment of 7,500 students. Although students reported frequent engagement in foundational QR tasks— such as calculation and interpretation—rubric-based scoring revealed inconsistent levels of mastery, particularly on higher-order skills like evaluation and coherence. Regression analyses linked confidence to calculation …

Does The National Benchmark Quantitative Literacy Test Predict Performance In Stem Programmes In Commerce, Engineering And Science?, Robert N. Prince

Numeracy

In South Africa, university completion rates remain low, with only 23% of students finishing within the regulation time (three or four years). These completion rates continue to reflect racial inequalities, with ‘White’ students significantly more likely to complete degrees in professional fields such as engineering and commerce compared to their ‘African’ counterparts. To address these challenges, the South African higher education institutions, through their umbrella body, introduced the National Benchmark (NB) tests to assess students’ academic literacy skills—including quantitative literacy, academic literacy, and mathematics—to identify those most at risk of struggling with the curriculum. The NB tests aim to evaluate …

Governors Slightly More Bound? A Critique Of The Uniform Law Commission's Model Public-Health Emergency Authority Act, Paul A. Diller

Kentucky Law Journal

No abstract provided.

Courting Jural Rights: The Kentucky Constitution And The Super Common Law Of Torts, Sarah L. Swan

Kentucky Law Journal

No abstract provided.

Protecting Public Employees' Free Speech: It's Time For The Sixth Circuit To Take Action, Faith O. Turner

Kentucky Law Journal

No abstract provided.

The End Of An Aberration: Overturning Major League Baseball's Century-Old Antitrust Exemption, Jacob Baird

Kentucky Law Journal

No abstract provided.

Fighting Death: A Critique Of Kentucky's Death Penalty System, Pamela R. Goodwine

Kentucky Law Journal

No abstract provided.

Ductile Rights, W. C. Bunting

Kentucky Law Journal

No abstract provided.

For One Or For All: Who Gets The Benefits Of The First Step Act?, Andrew Edwards

Kentucky Law Journal

No abstract provided.

The Major Question Left For The Roberts Court, Will Chevron Survive?, Caleb B. Childers

Kentucky Law Journal

No abstract provided.

Against Algorithmic Auer Deference, Chad Squitieri

Kentucky Law Journal

No abstract provided.

Review Of A Descriptive Bibliography Of Imprints From The Israelite House Of David And Mary’S City Of David, 1902–2010, Heather Van Wormer

Communal Societies

No abstract provided.

Discord In Utopia: Reconciling Perfectionism With Human Nature In The Oneida Community, Leigh Gialanella

Communal Societies

No abstract provided.

Early College Program Implementation And Growth: A Collaborative Initiative By A State University, Olcay Yavuz, Trudy Milburn

Concurrent Enrollment Review

This article explores a collaborative initiative undertaken by a state university aimed at implementing and expanding an Early College Program. The conceptual framework, practical strategies, collaborative efforts and background of this initiative are presented. With a focus on improving college access for all, the article introduces the university's efforts to promote an inclusive Early College Program accessible to high-need students in particular. This collaborative approach highlights the importance of fostering collaboration among both internal and external partners of Institutions of Higher Education (IHE). By sharing insights into the program design and implementation, the article aims to inspire similar initiatives and …

Book Review - The Idea Of A Christian School And Why It Matters For The Child You Love, Jared Johnston

International Christian Community of Teacher Educators Journal

A review of Stoner, Tom (2024). The idea of a Christian school and why it matters for the child you love. Wipf and Stock.

ISBN:979838521958, 160 pages

The Communal Studies Association At Forty: A Personal Retrospective, Donald E. Pitzer

Communal Societies

No abstract provided.

The Advent Of The Disappointed: Why The Millerites Joined The Shakers And Why They Quickly Left, Caroline Clarke

Communal Societies

No abstract provided.

Review Of Storming Zion: Government Raids On Religious Communities, Timothy Miller

Communal Societies

No abstract provided.

The Emancipation Of Shakerism, Philippe Chavance

Communal Societies

No abstract provided.

Camphill At Seventy-Five: Developmental Communalism In Process, Daniel Mckanan

Communal Societies

No abstract provided.

“Simple Gifts”: The Discovery And Popularity Of A Shaker Dance Song, Roger Lee Hall

Communal Societies

No abstract provided.

Death Of A Guru: An Analysis Of The Postcharismatic Phase In The Transcendental Meditation Movement, Lane Atmore

Communal Societies

No abstract provided.

How Standards Of Review Under Erisa Impair Mental Health Parity: An Analysis Of Wit V. United Behavioral Health, Hayden K. Hickey

Kentucky Law Journal

No abstract provided.

The Paradox Of Barring Early-Release Defendants From Section 1983 Relief, Emily M. Puckett

Kentucky Law Journal

No abstract provided.

Scotus's Summer Of 2022: Obfuscation Of And Disdain For Rationality And The Traditional Personal Liberties Framework, Roy G. Spece Jr.

Kentucky Law Journal

No abstract provided.

The Law Fox Manifesto, Benjamin H. Barton

Kentucky Law Journal

No abstract provided.