Digital Commons Network^™

Frameworks Of Genius: Fresco, Labor, Scaffolding, And Patronage In The Making Of Michelangelo's Sistine Chapel Ceiling, Jackelyn Eileen Adkins

Theses

This thesis examines how the materiality of production and the patronage of Pope Julius II influenced the visual and conceptual outcome of Michelangelo’s ceiling frescoes in the Sistine Chapel. It argues the physical demands of the fresco medium, the architectural constraints of the chapel, and the material infrastructure, such as the pigments, scaffolding, and spatial dynamics related to the political, theological, and ideological imperatives of papal authority. The materials served as a symbolic extension of Pope Julius II’s ambitions, embedding his message directly into the frescoes. By foregrounding the complex web of labor and materials that supported the project, this …

Improving Pharmacovigilance Via Systematic Gass Screening And Interdisciplinary Collaboration In The Outpatient Setting, Dustin Bower

Doctor of Nursing Practice Projects

The goal of this Doctor of Nursing Practice (DNP) quality improvement project was to enhance pharmacovigilance practices among non-medical mental health providers (NMMHPs) in an outpatient psychiatric setting. The project addressed the issue of limited recognition and reporting of adverse drug reactions (ADRs) by NMMHPs, which can lead to delays in clinical intervention and compromise patient safety. To tackle this problem, a quasi-experimental, pre–post intervention design was employed. Two evidence-based strategies were implemented: (a) eight weekly collaborative training sessions that focused on identifying, documenting, and communicating ADRs, and (b) the integration of the Glasgow Antipsychotic Side-Effect Scale (GASS) into the …

Quality Improvement Project Enhancing Documentation Practices In Community Mental Health Clinics, Carol Parker

Doctor of Nursing Practice Projects

Accurate and timely documentation are essential for safe, high-quality care in community mental health settings. This quality improvement (QI) project addressed inconsistent documentation practices among licensed, unlicensed, and Qualified Mental Health Specialist (QMHS) staff at an outpatient clinic. The purpose of the QI project was to implement and assess a structured in-service training program using the Accountable Health Communities–Health-Related Social Needs (AHC-HRSN) screening and documentation tool to improve staff knowledge, enhance documentation accuracy, and facilitate care coordination. Guided by the Iowa Model of Evidence-Based Practice and Lewin’s Change Management Model, a pre- and post-intervention design was used. Fifteen staff members …

Mindreading And Embodiment: Beyond Mirror Neurons., Sanad Al Khatib

College of Arts & Sciences Senior Theses

This paper examines the question: how do we figure out what other people are thinking and why they act as they do, or put differently, how is it that we can read minds in daily life? For decades, the dominant view held that we explain and predict other people’s behavior by attributing to them mental states such as beliefs, desires, and intentions, represented symbolically in the brain. The embodied simulation model challenges this view, proposing that understanding others primarily relies on mirror neurons that activate both when we perform an action and when we observe someone else performing it. This …

Dancing With Logic: The Impact Of Integrating Dance In Teaching Introductory Computer Science Concepts On Student Understanding And Engagement, April Monk

Master's Theses

The purpose of this study was to investigate the effectiveness of dance-integrated pedagogical methods in enhancing the learning experiences of students in an introductory computer science course. In particular, the research aimed to measure the impact of creative movement on student comprehension, engagement, and perceptions of computer science. To guide this investigation, the study explored three research questions: Does integrating dance into lessons impact students’ comprehension of fundamental computer science concepts? How does dance integration affect student perceptions of both dance and computer science? And what elements of dance contribute to differences in comprehension between dance-integrated and traditional lessons? A …

Effectiveness Of Education On Increasing Training Likelihood: An Analysis In Relation To Physique Inflation, Reid J. Venable

Honors College Theses

Resistance training is a widely recommended form of exercise for enhancing muscular strength, improving metabolic health, and promoting overall quality of life. In addition to these benefits, perhaps the most popular reason for participating in resistance training is to achieve muscle hypertrophy and attain a desired or aesthetic physique. However, various factors such as the use of performance-enhancing drugs and social media have led to “physique inflation,” a cultural phenomenon in which exposure to highly enhanced or unrealistic body types shifts perceptions of what is considered a “normal” or attainable physique. As a result, many individuals avoid or delay resistance …

Characterizing The Relationship Between Parturition In Beef Cattle And The Lunar Phase And Meteorological Factors., Caroline E. Chambers

Honors College Theses

For beef cattle, parturition is one of the most critical stages in the reproductive process. It is crucial that farmers understand the factors that may influence the timing of parturition. There is a persistent preconception that the onset of parturition is influenced by the lunar phase and weather factors. The objective of this study is to characterize the association between parturition in beef cattle, the lunar phase, and/or different weather factors such as barometric pressure and temperature. Cattle records were obtained from Chambers Family Farm in Cumberland Furnace, TN. Data was collected from 142 calvings from January 2017 to October …

Strategic Business Planning For An Optometry Practice: A Comprehensive Approach To Market Analysis, Operations, And Growth, Molly Elizabeth Weber

Honors College Theses

This study is a comprehensive analysis of the field of optometry in order to develop a business plan which could be utilized to open a new optometry practice. Strengths, weaknesses, opportunities, and threats are all studied in order to gain a robust view and offer insights of how a business would fair in the field of optometry to allow entrepreneurs to make informed decisions in business endeavors involving practice operations, market terrain, and growth potential.

Degradation Of Cobalt Chrome Molybdenum Hip And Knee Implants In Vivo And In Vitro, Peter William Kurtz

All Dissertations

Cobalt Chrome Molybdenum (CoCrMo) remains a popular material choice for femoral condyles in total knee arthroplasty and for acetabular liners in dual mobility total hip designs. CoCrMo has been phased out of conventional THA designs due to its correlation with adverse effects such as ALTR and ALVAL. It is less understood if the mechanisms (i.e. abrasive wear to the surface of the implant) that release metal ions into the surrounding tissue occur at similar rates as seen in conventional THA. Additionally, it is unknown what effect the secondary damage modes such as electrocautery damage and adhesive wear have on these …

Climate Change In The Courts: A 2025 Retrospective, Maria Antonia Tigre, Margaret Barry

Sabin Center for Climate Change Law

Drawing from cases collected in the Sabin Center’s Climate Litigation Database, this report offers insights into global climate litigation developments during 2025. This third installment in our year-end series provides a snapshot of how the field of climate litigation evolved over the course of the year. The report revisits significant rulings from around the world and connects them to eight illustrative themes: (1) climate change in international courts and tribunals; (2) environmental assessment and permitting; (3) non-compliance with climate commitments; (4) constitutional and human rights; (5) greenwashing and climate-washing; (6) corporate accountability cases; (7) standing; and (8) deregulatory suits.

Do Need For Cognition And Need For Affect Moderate The Relationship Between Lecture Style, Learning Strategies, And Retention?, Mary Chapman

Dissertations

Boredom is detrimental to academic achievement. Using shallow learning strategies such as rote memorization is similarly unfavorable for success in academic settings compared to using deep learning strategies such as generating examples. Such is the consensus among scholars, but research conducted in both constructs reveals inconsistencies. The purpose of this study was to experimentally manipulate boredom and learning strategies to determine how boredom and learning strategies impact achievement, as well as to investigate whether certain individual differences, need for cognition and need for affect, change the relationships between boredom, learning strategies, and retention. In an online study, I recruited 131 …

Hypercalcemia Of Down Syndrome., Seth Lmb, Melissa Litao, Nasreen Talib, Jacob M. Redel

Manuscripts, Articles, Book Chapters and Other Papers

We present a case of hypercalcemia in a 12-month-old female with Down syndrome. The patient presented with significant weight loss (810 g since her 6-month visit) and severe growth failure (weight 5.8 kg, -4.5 SDs). Laboratory evaluation revealed severe hypercalcemia with appropriately suppressed PTH and 1,25-hydroxyvitamin D levels. Renal ultrasound confirmed medullary nephrocalcinosis. After excluding common etiologies, the patient was diagnosed with hypercalcemia of Down syndrome, also termed Abnormal Calcium, Calcinosis, Creatinine in Down syndrome. Treatment with intravenous fluids, calcitonin, and transition to a low-calcium formula (Calcilo XD) normalized serum calcium levels. The patient maintained normal calcium levels on restricted …

Categorizing Weight Growth Of Infants Born Before 32 Weeks' Gestation Using The 2023 Postnatal Growth Charts For Preterm Infants., Fu-Sheng Chou, Hung-Wen Yeh, Crystal Hsueh, Jing Zhang, Maria Fe B. Villosis, Karine Barseghyan, Ashwini Lakshmanan, Reese H. Clark

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To categorize growth and correlate growth categories with morbidities in infants born before 32 weeks of gestation.

STUDY DESIGN: This retrospective study categorized weight growth by correlating mean growth velocity (GV) with growth trajectory z-score changes (ΔGTZ ), as measured using 2023 Postnatal Growth Charts for Preterm Infants. The associations between weight categories and morbidities were assessed.

RESULTS: Weight gain of infants without morbidities was categorized into three groups based on correlating ΔGTZ with mean GV: slower ( ΔGTZ < -0.1), in-parallel ( ΔGTZ -0.1 to 0.3), and faster ( ΔGTZ > 0.3). The proportions of infants with and without morbidities in these categories were evaluated across two distinct cohorts, revealing similar …

Left And Right Ventricular Strain Mechanics In Fetal Tachyarrhythmia., Rukmini Komarlu, Janelle R. Noel-Macdonnell Phd, Neha Chellu, Geetha Haligheri

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: Assessment of myocardial function in fetuses with supraventricular tachyarrhythmia is challenging. Speckle-tracking echocardiography (STE) is a newer sensitive method to assess ventricular systolic function. We sought to assess left (LV) and right (RV) ventricular myocardial strain mechanics in fetuses with tachyarrhythmia and hypothesized that strain mechanics are impaired in this patient population even after conversion to sinus rhythm.

METHODS: This was a single-center retrospective review. LV and RV strain parameters were assessed using STE in tachyarrhythmia and after conversion to sinus rhythm and, compared to gestational age (GA), matched control fetuses in sinus rhythm.

RESULTS: Eighteen fetuses with tachyarrhythmia …

Clinical Pharmacogenetics Implementation Consortium Guideline For Nat2 Genotype And Hydralazine Therapy., Michael T. Eadon, David W. Hein, Michael A. Andersen, Arlene B. Chapman, Rhonda M. Cooper-Dehoff, Zeruesenay Desta, Julio D. Duarte, Amanda L. Elchynski, Andrea Gaedigk, Seth E. Karol, Nita A. Limdi, Christelle Lteif, Laura Sosinski, Pablo Zubiaur, Michelle Whirl-Carrillo, Teri E. Klein, Kelly E. Caudle, Roseann S. Donnelly, José A G Agúndez

Manuscripts, Articles, Book Chapters and Other Papers

Hydralazine is a vasodilator typically used in the treatment of resistant hypertension and heart failure. N-acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as "slow acetylators") are predicted to have increased plasma hydralazine concentrations compared with NAT2 rapid and intermediate metabolizers (historically referred to as "rapid acetylators" and "intermediate acetylators," respectively), which may lead to both increased clinical efficacy and adverse effects, including drug-induced systemic lupus erythematosus. This guideline summarizes the evidence from the literature relevant to NAT2/hydralazine and provides recommendations for hydralazine prescribing based on NAT2 genotype-predicted acetylator phenotype (updates …

The Effect Of Shared Decisions On Intertemporal Choice, Rosemarie M. Davidson

Masters Theses

Substance use disorders are a significant public health concern, and improving treatment outcomes requires a better understanding of the behavioral processes that influence drug consumption. Delay discounting, or the tendency to overvalue immediate reinforcers, is reliably more severe among individuals with substance use disorders. Recent work suggests that shared decision-making may increase tolerance for delayed rewards; however, prior studies used procedures that confounded delay to token delivery with delay to token exchange, limiting conclusions. The present study evaluates delay discounting across individual and social decision-making contexts using a traditional delay discounting paradigm.

Ten undergraduate participants completed sessions involving choices between …

Clinical Long-Read Sequencing Test For Genetic Disease Diagnosis., Isabelle Thiffault, Emily G. Farrow, Cassandra Barrett, Meadow Scott, Amy Ross, John C. Means, Warren A. Cheung, Adam F. Johnson, Boryana Koseva, Rebecca Mclennan, Elin Grundberg, Chengpeng Bi, Carl F. Schreck, Byunggil Yoo, Jeffrey J. Johnston, Florencia Del Viso, Vitoria Paolillo, John Herriges, Lei Zhang, Margaret Gibson, Ana S A Cohen, Joseph Alaimo, Carol J. Saunders, Tomi Pastinen

Manuscripts, Articles, Book Chapters and Other Papers

This diagnostic study examines the diagnostic yield and turnaround time of long-read sequencing compared to standard-of-care approaches.

Halo Gravity Traction And Temporary Internal Distraction, Nicholas D. Fletcher, Anson G. Bautista, Joshua S. Murphy, K Aaron Shaw

Manuscripts, Articles, Book Chapters and Other Papers

Severe pediatric spinal deformities may require staged correction strategies to mitigate neurologic risk and optimize cardiopulmonary outcomes. This paper reviews two adjunctive techniques—halo gravity traction (HGT) and temporary internal distraction (TID)—used in the management of rigid scoliosis. HGT enables gradual preoperative spinal elongation and coronal/sagittal realignment, improving pulmonary function and nutritional status while reducing the need for three-column osteotomies. TID offers an internal, staged distraction approach for patients contraindicated for external traction, allowing incremental correction via posterior instrumentation followed by definitive fusion. Clinical studies report Cobb angle reductions of 30–80 %, with low rates of neurologic complications when neuromonitoring and …

Overview Of Huntington's Disease And Emerging Treatment Strategies: A Narrative Review, Alexis J. Vega, Gabriel V. Hernandez, Pearse A. O'Malley, Connor J. Robin, Amanda N. Parra, Giustino Varrassi, Sahar Shekoohi, Alan D. Kaye

School of Medicine Faculty Publications

Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by a cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin (HTT) gene. The symptoms of HD include severe motor dysfunction, cognitive issues, and emotional dysregulation. These combined issues are not only debilitating but also lead to depression/anxiety, increased suicide rates, and caregiver burnout. Our narrative review summarizes several recent studies examining the efficacy and differences among emerging treatment strategies for HD. A systematic search of peer-reviewed literature was conducted, focusing on recent studies that describe molecular genetic manipulation of the HTT gene/huntingtin protein. The results of our narrative review reveal …

Moon Moth, Britain Noelle Powers

Open Access Theses & Dissertations

No abstract provided.

A Learning‑Augmented Dynamic Programming Approach For Orienteering Problem With Time Windows, Guansheng Peng, Lining Xing, Fuyan Song Ma, Aldy Gunawan, Aldy Gunawan

Research Collection School Of Computing and Information Systems

Recent years have witnessed a surge of interest in solving combinatorial optimization problems (COPs) using machine learning techniques. Motivated by this trend, we propose a learning-augmented exact approach for tackling an NP-hard COP, the Orienteering Problem with Time Windows, which aims to maximize the total score collected by visiting a subset of vertices in a graph within their time windows. Traditional exact algorithms rely heavily on domain expertise and meticulous design, making it hard to achieve further improvements. By leveraging deep learning models to learn effective relaxations of problem restrictions from data, our approach enables significant performance gains in an …

Semi‑Supervised Graph Anomaly Detection Via Robust Homophily Learning, Guoguo Ai, Hezhe Qiao, Hui Yan, Guansong Pang

Research Collection School Of Computing and Information Systems

Current semi-supervised graph anomaly detection (GAD) methods utilizes a small set of labeled normal nodes to identify abnormal nodes from a large set of unlabeled nodes in a graph. These methods posit that 1) normal nodes share a similar level of homophily and 2) the labeled normal nodes can well represent the homophily patterns in the entire normal class. However, this assumption often does not hold well since normal nodes in a graph can exhibit diverse homophily in real-world GAD datasets. In this paper, we propose RHO, namely Robust Homophily Learning, to adaptively learn such homophily patterns. RHO consists of …

Fusarium Equiseti Pathogen Of Potato In Kenya And Its Potential In Vitro Biocontrol Using Fungal Endophytes, Marie Cecile Muhorakeye, Fathiya M. Khamis, Everlyne Samita Namikoye, Komivi S. Akutse

All Peer-Reviewed Publications

Accurate pathogen diagnosis is fundamental for effective crop disease management. In Kenya, a pathogen causing significant damage in potato farms was initially misidentified as Phytophthora infestans. This study aimed to correctly identify this pathogen and explore initial control measures using a polyphasic approach. The methodology integrated morphological observation, pathogenicity testing, and molecular analysis using ITS and EF1-α gene sequencing. The results confirmed the pathogen’s identity as Fusarium equiseti, with morphological features consistent with this species and molecular sequencing showing 99.6% identity to reference strains. This is the first official report of Fusarium equiseti as a potato pathogen in Kenya. Furthermore, …

Rapid Incorporation But Contrasting Stability Of Fertilizer Versus Litter Nitrogen In Mineral-Associated Organic Matter, Emma Bergh

Master's Theses and Capstones

Nitrogen (N) is abundant in agricultural soils during early spring due to both decomposing plant residues and initial fertilizer applications before peak crop uptake. This N is vulnerable to loss through leaching and denitrification, but a portion of this N can become stabilized in mineral-associated organic matter (MAOM). However, the short-term incorporation and long-term stability of different N sources within MAOM remain poorly understood. This study examined how fertilizer and litter derived N are incorporated and stabilized in MAOM using a three-week incubation experiment with 15N labeled fertilizer, rye root, and rye shoot additions to paired cropland and grassland soils. …

Potential Predictors Of Nonconductive Wood Column Volumes In Five Maple Species, Tanner Ryan Frost

Master's Theses and Capstones

Maple tapping guidelines rely on the understanding of nonconductive wood column (NWC) formation, but this process has only been studied in sugar maple and may be ineffective at advising producers in their tapping activities due to the variation in wounding between sites and the lack of research into alternative species more recently being brought to market. The goal of this study was to investigate sap sugar concentrations and sap yields as predictors of nonconductive wood column (NWC) volumes in five Acer species: sugar maple (Acer saccharum), red maple (Acer rubrum), silver maple (Acer saccharinum), Norway maple (Acer platanoides), and boxelder …

Underwater Remote Sensing Of Oil: Validation Testing Of A Commercial-Off-The-Shelf Acoustic Sensor For Emergency Response, Sara Jessica Berg

Master's Theses and Capstones

During an oil spill, emergency responders need to be able to estimate the thickness of oil to determine the type of recovery equipment to use and the environmental impact for natural resource damage assessment, perform a risk assessment, and generate response plans. There is an abundance of remote sensing techniques and devices that have been evaluated for use in oil spill emergency response. One that has repeatedly shown promise is active sound navigation and ranging (SONAR) system that transmits and receives acoustic signals. However, the systems that have been tested are often prototypes, not readily available during an oil spill …

Preliminary Analysis Of A Wave Energy Converter For Remote Power Generation, William Frank Pelger Ii

Master's Theses and Capstones

This thesis presents the design, development, and characterization of a free-floating Oscillating Water Column (OWC) Wave Energy Converter (WEC) created by the University of New Hampshire (UNH) Center for Sustainable Seafood Systems (CSSS) in collaboration with the United States Naval Academy (USNA) Naval Architecture and Ocean Engineering Department. The project aims to advance small-scale WEC technologies for integration into aquaculture systems along with remote military applications.The initial design and construction of the OWC was completed as a USNA senior capstone project, providing the foundation for subsequent development and testing. The OWC was tested in the UNH Jere A. Chase Ocean …

An Inter-Model Comparison Of Snow Water Equivalent In Watershed 3, Hubbard Brook Experimental Forest, For Winter 2023-2024, Ryan Reed

Master's Theses and Capstones

Estimates of snow water equivalent (SWE) are crucial for water availability and flood risk assessment due to the contribution of snow melt to increased surface runoff. However, many regions do not have observations of SWE, thus necessitating a robust method to estimate SWE for streamflow forecasting. Numerical snowpack models provide a potential way to estimate SWE in areas without observations. However, there are a multitude of snowpack models available, and they range greatly in their complexity. Even so, there have been few snowpack model intercomparisons to assess the trade-offs in model performance and complexity, and those that do exist did …

Suspending The Truancy Paradigm, Barbara Fedders, Lucy Carlson, Max Parker

Buffalo Law Review

In the aftermath of the COVID-19 pandemic, school absences have skyrocketed. While racially minoritized, disabled, and low-income students have historically been, and remain, most likely to experience absence, white and affluent students’ rates of attendance have also declined. To respond to this new universality of student absenteeism, some policymakers have begun to seek alternatives to what we term “the truancy paradigm.”

We define the truancy paradigm as the range of coercive and often punitive interventions deployed by states and school districts to enforce compulsory attendance statutes. This paradigm, we argue, wrongly assumes (a) that strict enforcement of compulsory attendance laws …

Presumed Guilt: Epistemic Closure In Pregnancy Prosecutions, M. Eve Hanan

Buffalo Law Review

Criminal law and reproductive justice scholars are calling attention to the increase in prosecutions for pregnancy outcomes in the United States. Trace amounts of controlled substances in newborns are prosecuted as child abuse. Miscarriages are prosecuted as illegal abortions or homicides. This area of criminal law existed side-by-side with Roe v. Wade for late-term pregnancy outcomes. The Dobbs decision has further emboldened these prosecutions by removing the protections of the Due Process Clause from the pre-viability phase of the pregnancy.

Using a case study of a woman who was pressured to plead guilty to manslaughter and sentenced to eight years …