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Parametric Control And Amplification In Superconducting Quantum Systems: From Entanglement Probes To Pt-Symmetric Architectures, Chandrashekhar Rao Gaikwad Dec 2025

Parametric Control And Amplification In Superconducting Quantum Systems: From Entanglement Probes To Pt-Symmetric Architectures, Chandrashekhar Rao Gaikwad

Arts & Sciences Graduate Student Theses and Dissertations

The precise control, entanglement, and measurement of quantum systems are central challenges in realizing scalable quantum information processing. This dissertation investigates how parametric modulation and engineered nonlinearity can be harnessed to both manipulate and measure superconducting qubits with high fidelity. In one part, controlled parametric drives are used to generate entanglement between qubit pairs and employ their joint states as probes of environmental dynamics. This approach enables the exploration of the non-Markovian nature of quantum environments, revealing how memory effects influence qubit coherence and energy relaxation. In a separate but conceptually related study, the same principle of parametric driving is …


100 Years: The Uniform System Of Accounts For The Lodging Industry (Usali) 12th Revised Edition, Agnes Defranco, Raymond S. Schmidgall Dec 2025

100 Years: The Uniform System Of Accounts For The Lodging Industry (Usali) 12th Revised Edition, Agnes Defranco, Raymond S. Schmidgall

Journal of Hospitality Financial Management

No abstract provided.


Construction Of A Unified Knowledge Graph For Cyber Threat Intelligence, Moaz Usama Hassan Mr, Khaled , Nagaty, Noura Elmaghawry Dec 2025

Construction Of A Unified Knowledge Graph For Cyber Threat Intelligence, Moaz Usama Hassan Mr, Khaled , Nagaty, Noura Elmaghawry

Computer Networks

The rapid expansion and variety of cyber-threat information put enormous pressure on security operations centers (SOCs) that must convert unstructured data into understandable signals and make decisions upon it. This paper develops a Cyber-Threat-Intelligence (CTI) framework that integrates vulnerability information, product inventories, and weakness taxonomies into a domain-specific knowledge graph via automatic fusing. The proposed solution covers 284,296 CVEs, 101,644 CPE identifiers, and 965 CWE weaknesses, generating more than 800,000 typed edges linking threats, assets, tactics, and mitigations in an integrated CTI Knowledge graph. The graph was cross validated against four external standard datasets achieves full coverage of ATT&CK CAPEC, …


Pioneering Insights Into The Complexities Of Salt-Sensitive Hypertension: Central Nervous System Mechanisms And Dietary Bioactive Compound Interventions, Renjun Wang, Bo Xu, Xiping Liu, Qi Guo, Gregory Miodonski, Zhiying Shan, Dongshu Du, Qing Hui Chen Dec 2025

Pioneering Insights Into The Complexities Of Salt-Sensitive Hypertension: Central Nervous System Mechanisms And Dietary Bioactive Compound Interventions, Renjun Wang, Bo Xu, Xiping Liu, Qi Guo, Gregory Miodonski, Zhiying Shan, Dongshu Du, Qing Hui Chen

Michigan Tech Publications

Salt-sensitive hypertension (SSH) is an important and common subtype of hypertension, whose pathogenesis involves multi-level regulation, including the central nervous system (CNS), metabolic stress, and epigenetics. Dietary bioactive compounds have emerged as a research hotspot for SSH intervention due to their safety and multi-target effects. Although existing studies have focused on the CNS regulation of SSH or the role of individual dietary components, there is a lack of comprehensive analysis integrating multiple mechanisms, systematically summarizing multiple compounds, and incorporating a clinical translation perspective. This review first outlines the mechanisms of CNS pathways, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and epigenetic …


Minutes From December 17 2025, University Senate Dec 2025

Minutes From December 17 2025, University Senate

University Senate Minutes

Minutes from December 17 2025 University Senate Meeting


Unraveling The Drivers Of Inequality In Maternal Healthcare Utilization In Indonesia: A Decomposition Analysis, Wji Wahyuningsih, Kemal N. Siregar, Syifa Nurhakiki Dec 2025

Unraveling The Drivers Of Inequality In Maternal Healthcare Utilization In Indonesia: A Decomposition Analysis, Wji Wahyuningsih, Kemal N. Siregar, Syifa Nurhakiki

Jurnal Ekonomi Kesehatan Indonesia

This study assessed socioeconomic inequalities in maternal healthcare utilization in Indonesia and identifies key factors driving these inequalities. We used data from 2013 and 2023 Indonesian Health Surveys, comprised of a total unweighted sample of 15,638 and 9,923 women aged 15-49 in the 2013 and 2023, respectively. Concentration index (CI) measured wealth-based inequality, and decomposition analysis identified primary drivers of inequalities in maternal healthcare access. Overall maternal healthcare service utilization has increased, but significant inequalities persist. Antenatal care showed minimal improvement, with the CI rising from 0.059 to 0.079, indicating a persistent higher socioeconomic distribution. Facility-based deliveries improved, with the …


The Conditional Nature Of The Value Premium: Interaction And Cross-Sectional Evidence Across Market Regimes, Samuel L. Klein Dec 2025

The Conditional Nature Of The Value Premium: Interaction And Cross-Sectional Evidence Across Market Regimes, Samuel L. Klein

Honors Thesis

This thesis examines why value-based investment strategies generate strong returns in some environments yet weaken or collapse in others. Regressions test whether the performance of the book-to-market ratio depends on the investor’s perception of financial health as defined by F-Score and accruals. Across additive regressions, interaction models, cross-sectionals, and heatmap visualizations, a consistent mechanism emerges. The book-to-market effect is strongest when financial information is neither highly reliable nor severely distressed. In these “moderate-quality” environments, investors struggle to fully distinguish the transitory components of earnings from their persistent counterparts. This makes valuation ratios particularly influential. Accrual intensity and financial strength jointly …


Evaluating The Performance Of The Primary Heat Exchanger In A Sco2 Brayton Cycle While Firing Solid Fuels, Brian Jeffrey Schooff Dec 2025

Evaluating The Performance Of The Primary Heat Exchanger In A Sco2 Brayton Cycle While Firing Solid Fuels, Brian Jeffrey Schooff

Theses and Dissertations

The sCO2 closed-loop Brayton cycle is an alternative to the standard steam-Rankine cycle for generating electrical power from a heat source. The sCO2 Brayton cycle is advantageous because it can be more efficient, use less water, and have smaller turbomachinery than the steam-Rankine cycle. While there are several research groups advancing the technology necessary to utilize the sCO2 Brayton cycle on an industrial scale, none of these groups use solid fuel combustion as the heat source. A Brigham Young University-led project developed and tested a pilot-scale sCO2 Brayton cycle unit (1.6 MWth) using natural gas, pulverized coal, and pulverized biomass …


Trauma-Informed Training And Practices For Elementary School Lunchroom Supervisors, Heather C. Kostohryz Dec 2025

Trauma-Informed Training And Practices For Elementary School Lunchroom Supervisors, Heather C. Kostohryz

Dissertations, Theses, and Projects

School lunchrooms often see behavior disruptions at a higher rate than other areas within a school. Of the numerous reasons as to why, the inadequate training of those who supervise the lunchroom can be remedied easier than other factors (Wheatley et al., 2009). Over the past ten years a growing recommendation is for all staff to be included in school-wide behavior management and training, and that the training be focused on trauma-informed practices as a way to aid all students (Nealy-Oparah & Scruggs-Hussein, 2018). As 68% of children will experience some form of trauma during childhood, it stands to reason …


Beyond The Standard: A Sociolectal And Probabilistic Turn In Philippine English Phonology, Teri An Joy G. Magpale Dec 2025

Beyond The Standard: A Sociolectal And Probabilistic Turn In Philippine English Phonology, Teri An Joy G. Magpale

Journal of English and Applied Linguistics

This article advocates for probabilistic approaches as a key framework for understanding Philippine English (PhE) phonology, arguing that they reveal socially conditioned variation that traditional descriptive models overlook. Tracing five decades of research, it critiques early standardization efforts and studies centered on scripted speech and elite norms, and highlights the sociolectal turn initiated by Tayao (2004). The discussion foregrounds recent methods that combine instrumental phonetics with constraint-based frameworks, including Optimality Theory (OT) and Maximum Entropy grammar (MaxEnt), to model gradient variation across acrolectal, mesolectal, and basilectal speakers. By synthesizing findings on segmental features, phonotactic patterns, and speech rhythm, the article …


Top-Ranking Grammatical Keyword In Hong Kong English, Chi Wui Ng Dec 2025

Top-Ranking Grammatical Keyword In Hong Kong English, Chi Wui Ng

Journal of English and Applied Linguistics

Most grammar research of Hong Kong English has been conducted from perspectives of error analysis and interlanguage studies. The present corpus-based study investigates the top-ranking grammatical keyword in Hong Kong English in relation to other English varieties to identify one-of-a-kind morphosyntactic attributes of Hong Kong English systematically. The grammatical keyword with the highest keyness in the Hong Kong component of the International Corpus of English was identified through comparison with a reference corpus comprising six other components of the corpus with the corpus analysis software WordSmith 5.0. The modal auxiliary verb “will” was identified as the top-ranking grammatical keyword in …


Reducing The Use Of Erythropoiesis-Stimulating Agents In Hemodialysis Patients, Myriamme Neree Dec 2025

Reducing The Use Of Erythropoiesis-Stimulating Agents In Hemodialysis Patients, Myriamme Neree

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice project was a quality improvement (QI) initiative. Nephrologists were inconsistent in ordering iron studies and sometimes delayed the initiation of erythropoiesis-stimulating agents (ESAs) on admission to the inpatient site. These delays often led to suboptimal outcomes. The practice-focused question guiding the project asked whether a nurse-driven iron protocol would improve adherence to anemia management guidelines. The project’s purpose was to evaluate the impact of the evidence-based nurse-driven protocol. I used descriptive and inferential statistics for data analysis. Findings demonstrated a statistically significant improvement in the timely completion of iron studies and in intravenous (IV) iron …


Book Reviews, Usawc Press Dec 2025

Book Reviews, Usawc Press

The US Army War College Quarterly: Parameters

No abstract provided.


Design, Synthesis And Biological Activities Of N-Substituted Phthalimide Derivative, Beaula Mangundah Dec 2025

Design, Synthesis And Biological Activities Of N-Substituted Phthalimide Derivative, Beaula Mangundah

Honors Theses

Phthalimides are a group of compounds among bicyclic non-aromatic nitrogen heterocycles that have gained recognition for their bioactivity across various fields, notably anti-cancer, anti-microbial, anti-oxidant, and anti-inflammatory. This study discusses the synthesis of a novel phthalimide derivative and provides an analysis of its biological activity. It was conducted through a Boric acid Imide synthesis and yielded a successful derivative using hexylamine. The product was evaluated in vitro for antimicrobial, anticoagulant, and anti-inflammatory properties using Kirby-Bauer disk diffusion, clotting time, hemolysis inhibition, and protein denaturation assays. It showed mild anticoagulant and anti-inflammatory activity.


Urinothorax And Empyema: Presentation Of An Unusual Complication Of A Rare Condition, Nolan Fox, Nicholas Fox, Shourjo Chakravorty, Neeraj Sinha Dec 2025

Urinothorax And Empyema: Presentation Of An Unusual Complication Of A Rare Condition, Nolan Fox, Nicholas Fox, Shourjo Chakravorty, Neeraj Sinha

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

A 68-year-old male with a history of metastatic bladder cancer and urinary obstruction presented with intractable hiccups and chest pain is presented in this case. He was found to have a unilateral pleural effusion in addition to ipsilateral renal metastasis abutting the diaphragm. Imaging revealed empyema. Thoracentesis revealed positive cultures and a lack of malignant cells on cytology. Comorbid urinary obstruction and urinary tract infection suggested the rare diagnosis of an infected urinothorax. Thoracentesis also revealed pleural fluid creatinine greater than serum creatinine, meeting the most specific diagnostic criteria for urinothorax and establishing the diagnosis. Treatment aimed at evacuating the …


Unmasking Oral Health Stigma: A Qualitative Scoping Review, J Doughty, J Booth, M Smith, K Saini, M Paisi, A Rodriguez, A Levine, C Bedos, V Muirhead, C Martins De Barros, C Freeborn Dec 2025

Unmasking Oral Health Stigma: A Qualitative Scoping Review, J Doughty, J Booth, M Smith, K Saini, M Paisi, A Rodriguez, A Levine, C Bedos, V Muirhead, C Martins De Barros, C Freeborn

Peninsula Dental School

INTRODUCTION: Health-related stigma can limit access to care, impair adherence to treatment, and negatively impact mental health and quality-of-life. Oral health stigma, defined as stigma arising from oral conditions that diverge from sociocultural norms, operates through labelling, stereotyping, othering, and exclusion. Oral health stigma can lead to shame, diminished self-confidence, and avoidance of dental care, creating a self-perpetuating cycle of poor oral health and reinforcing internalised and anticipated stigma. While previous research has explored the social implications of oral appearance, little is known about the broader concept of oral health stigma or strategies to mitigate it.

METHODS: This scoping review …


Determination Of The Cecal Microbiota Profile Of Anadolu-T Broiler Breeder Chickens Using 16s Metagenomic Sequencing, Kürşat Teti̇k, İsmai̇l Özkan, Serpi̇l Kahya Demi̇rbi̇lek Dec 2025

Determination Of The Cecal Microbiota Profile Of Anadolu-T Broiler Breeder Chickens Using 16s Metagenomic Sequencing, Kürşat Teti̇k, İsmai̇l Özkan, Serpi̇l Kahya Demi̇rbi̇lek

Turkish Journal of Veterinary & Animal Sciences

The gut microbiota has significant effects on the performance, health status, and immune systems of chickens. The complex microbial community structure begins to form after chicks hatch with the intake of feed, water, and air into the digestive system. Disrupting the balance of this system can lead to the proliferation of pathogenic microorganisms. Until recently, studies on microbiota relied on traditional microbiological techniques that cultured only a small fraction of the microbial diversity. However, significant advancements in DNA sequencing and bioinformatics have enabled the identification of diverse bacterial populations in environmental samples. In this study, a total of 2000 broiler …


Parameter Optimization For Runs Of Homozygosity (Roh) Detection In The Pig Genome, Timofey Romanets, Anna Korobeynikova, Lyubov Getmantseva, Maria Kolosova, Elena Romanets, Ilona Bakoeva, Varvara Shevtsova, Anatoly Kolosov, Alexander Maksimov, Siroj Bakoev Dec 2025

Parameter Optimization For Runs Of Homozygosity (Roh) Detection In The Pig Genome, Timofey Romanets, Anna Korobeynikova, Lyubov Getmantseva, Maria Kolosova, Elena Romanets, Ilona Bakoeva, Varvara Shevtsova, Anatoly Kolosov, Alexander Maksimov, Siroj Bakoev

Turkish Journal of Veterinary & Animal Sciences

The present study analyses the influence of various parameters on the accuracy and reliability of ROH identification procedures, as well as their relationship with inbreeding and genetic diversity in Duroc pig populations. The genotyping data of 70 Duroc pigs obtained using PorcineSNP80v1 chips were used, and the effects of LD pruning and ROH calling parameters were evaluated. It was found that the use of strict basic filters during the execution of the --homozyg command reduces the likelihood of false positives and contributes to the more accurate identification of ROH. The results show that LD pruning reduces the detection of random …


Endocrine Disruptors And Pregnancy, Betül Yi̇ği̇t Yalçin, Gamze Bi̇li̇k Oyman, Ayşe Kubat Üzüm Dec 2025

Endocrine Disruptors And Pregnancy, Betül Yi̇ği̇t Yalçin, Gamze Bi̇li̇k Oyman, Ayşe Kubat Üzüm

Turkish Journal of Medical Sciences

Sensitivity to endocrine disruptors is higher in early life. In pregnant women, endocrine disruptor chemicals can be passed to the baby through the placenta or through breast milk during lactation, leading to long-term and permanent adverse effects. These endocrine disruptors may cause adverse effects in women such as infertility, implantation defects, premature birth, spontaneous abortions, gestational hypertension, gestational diabetes. Exposure to endocrine disruptors in the intrauterine period may result in adverse effects on the reproductive system, metabolic changes, low birth weight, retardation in mental and physical development and also may be associated with congenital malformations. It is of great importance …


The Effects Of Endocrine Disruptors On The Female Reproductive System, Riza Gökhan Baykal, Reyhan Ersoy Dec 2025

The Effects Of Endocrine Disruptors On The Female Reproductive System, Riza Gökhan Baykal, Reyhan Ersoy

Turkish Journal of Medical Sciences

Endocrine-disrupting chemicals (EDCs) are a diverse, comprehensive group of mostly synthetic chemicals that disrupt many physiological functions in humans and animals. EDCs are particularly disruptive to the female reproductive system. Reproductive function in women is a dynamic process regulated by the hypothalamic–pituitary–ovarian axis. EDCs show their effects on the reproductive system through estrogenic, antiestrogenic, androgenic, and antiandrogenic effects or by directly affecting gonadotropin-releasing hormone secretion. Disruption in the menstrual cycle, decrease in fertility, infertility, increased risk of miscarriage, polycystic ovary syndrome, endometriosis, early or delayed puberty, and hormone-sensitive cancers can be listed as the main negative effects of endocrine disruptors …


Development Of A Multispectral Collagen Detection Dermatology Device For Delineation Of Non-Melanoma Skin Cancers, Anmol Jarang Dec 2025

Development Of A Multispectral Collagen Detection Dermatology Device For Delineation Of Non-Melanoma Skin Cancers, Anmol Jarang

McKelvey School of Engineering Graduate Student Theses & Dissertations

To diagnose and manage skin disease, clinicians primarily use visual inspection aided with dermatoscopes, which are cross-polarized magnifiers. In recent years, digital cross polarized multispectral imaging systems have been developed to quantitatively assess skin disease. For example, systems like the one developed by Yaroslavsky et al., which utilize red and blue filters, can non-invasively assess the collagen network in the dermis(Yaroslavsky et al., 2003). Visualization of collagen network disruption can make it easier to visualize the boundaries of skin cancers like keratinocyte carcinoma, and therefore easier to excise completely. Current systems use external bandpass filters in front of cameras to …


Tests Without Borders: A Global Approach To Measuring Visualization Literacy, Olivia A. Guess Dec 2025

Tests Without Borders: A Global Approach To Measuring Visualization Literacy, Olivia A. Guess

McKelvey School of Engineering Graduate Student Theses & Dissertations

Visualization literacy assessments shape how we understand people's ability to interpret data, yet most existing instruments embed Western datasets and assumptions that limit their relevance for global audiences. This thesis argues that because data is personal, assessments must also be culturally grounded. We introduce a unified framework for adapting the Mini-VLAT into 22 regionally responsive short-form assessments, each retaining the structure of the original test while incorporating datasets and scenarios tailored to specific regions around the world. To demonstrate how such adaptations can be customized and validated, we present a detailed case study of a Ghana-adapted Mini-VLAT, developed in collaboration …


Enhancing Aerosol Scattering Measurements: Performance Evaluation And Quality Assurance Of Airphoton Integrating Nephelometers In The Surface Particulate Matter Network, Kamlendra Singh Pathak Dec 2025

Enhancing Aerosol Scattering Measurements: Performance Evaluation And Quality Assurance Of Airphoton Integrating Nephelometers In The Surface Particulate Matter Network, Kamlendra Singh Pathak

McKelvey School of Engineering Graduate Student Theses & Dissertations

Integrating nephelometers are key instruments for quantifying aerosol light scattering, a fundamental parameter governing the direct radiative effect of aerosols on climate and visibility, and for interpreting satellite observations of aerosol optical depth. The AirPhoton integrating nephelometer quantifies aerosol light scattering by measuring total scattering from the sample air and subtracting a clean-air reference that represents Rayleigh scattering, instrument wall scattering, and detector background noise. Measurement accuracy depends on rigorous calibration and regular performance evaluation to account for instrumental drift and environmental influences. This study presents a field performance evaluation of the AirPhoton integrating nephelometer within the global Surface Particulate …


Behavior Analytic Food Reinforcement Use And Guidelines In Interventions For Children With Autism, Christopher Rogers Dec 2025

Behavior Analytic Food Reinforcement Use And Guidelines In Interventions For Children With Autism, Christopher Rogers

Electronic Theses and Dissertations 2020 - Present

Reinforcers create opportunities to increase behaviors in applied behavioral analysis, with healthy and unhealthy foods offering high reinforcing value. The use of food raises ethical and health concerns, so researchers and behavior analysts often avoid food reinforcement altogether. Kronfli et al. (2024) indicate healthy food alternatives bring about similar rates of responding as snack foods, potentially reducing ethical and health concerns. This research presents the question: To what degree are food reinforcers used in behavioral interventions for children with autism spectrum disorder? This review analyzes behavioral research articles containing the words “food,” “edible,” “autism,” and “children” in the context of …


Co-Production Of A Mobile Application For Parents Of Acutely Ill Children Under Five: ‘Ipoorly Child Symptom Checker, Sarah Neill, Amy Rathbone, John Downey, Monica Lakhanpaul, Matt Carey Dec 2025

Co-Production Of A Mobile Application For Parents Of Acutely Ill Children Under Five: ‘Ipoorly Child Symptom Checker, Sarah Neill, Amy Rathbone, John Downey, Monica Lakhanpaul, Matt Carey

School of Nursing and Midwifery

Acutely ill children under five years of age are frequent and increasing users of urgent and emergency care services despite there being no increase in acuity of presenting illnesses. This raises concerns about parents’ level of knowledge and confidence in assessing the severity of symptoms of acute illness, despite the abundance of digital information available. MethodBuilding on prior work to co-develop the content for a mobile app for parents of acutely ill children, we co-designed the iPoorly child symptom checker app using an experience based co-design methodology with seven parent and seven health professional patient and public involvement representatives. The …


Effects Of Exposure Route And Surface Coating On The Bioaccumulation Of Cdte Quantum Dots In Fish. Considerations For Testing Nanomaterials Following Oecd Test Guideline No. 305, Judit Kalman, Rocío Fernández-Saavedra, Carla Díaz-Tielas, Mona Connolly, Ana I. Cardona-García, Nathaniel Clark, Richard D. Handy, Eric A.J. Bleeker, Isabel Rucandio, José María Navas, María Luisa Fernández-Cruz Dec 2025

Effects Of Exposure Route And Surface Coating On The Bioaccumulation Of Cdte Quantum Dots In Fish. Considerations For Testing Nanomaterials Following Oecd Test Guideline No. 305, Judit Kalman, Rocío Fernández-Saavedra, Carla Díaz-Tielas, Mona Connolly, Ana I. Cardona-García, Nathaniel Clark, Richard D. Handy, Eric A.J. Bleeker, Isabel Rucandio, José María Navas, María Luisa Fernández-Cruz

School of Biological and Marine Sciences

To identify nanomaterials of potential environmental concern and to support risk assessment for regulatory purposes bioaccumulation testing is required. However, further guidance is needed when applying the fish bioaccumulation OECD test guideline (TG) No. 305 to nanomaterials. Also questions remain surrounding the most appropriate exposure route and if subtle modifications to these materials (e.g. different coatings) will influence bioaccumulation potential. Therefore in this study OECD TG 305 was applied to assess the bioaccumulation potential of CdTe quantum dots (QDs) with additional considerations for testing nanomaterials. CdTe QDs were selected for our studies because of their increasing use, possible release to …


University Living Labs For Sustainability: Governance, Pedagogy, And Global North-South Patterns, Skilty C. Labastilla Dec 2025

University Living Labs For Sustainability: Governance, Pedagogy, And Global North-South Patterns, Skilty C. Labastilla

Journal of Management for Global Sustainability

This scoping review examines how 72 higher education institutions (HEIs) operationalize sustainability through living labs (LLs), synthesizing evidence from 89 studies published between 2010 and 2025. Using Arksey and O’Malley’s (2005) framework, the review maps how LLs coordinate governance, pedagogy, operational experimentation, and stakeholder engagement, comparing 63 Global North (GN) and 26 Global South (GS) cases. GN LLs feature formalized governance and resource-intensive infrastructures linking curriculum, operations, and data-driven experimentation. GS LLs operate under resource constraints but exhibit strong community embedding, participatory co-production, and socio-ecological responsiveness. Institutionalization depends on hybrid configurations where bottom-up experimentation aligns with top-down authority. Observed governance, …


Her2-Low And Her2-Ultralow Metastatic Breast Cancer And Trastuzumab Deruxtecan: Common Clinical Questions And Answers, Nusayba A Bagegni, Karthik V Giridhar, Daphne Stewart Dec 2025

Her2-Low And Her2-Ultralow Metastatic Breast Cancer And Trastuzumab Deruxtecan: Common Clinical Questions And Answers, Nusayba A Bagegni, Karthik V Giridhar, Daphne Stewart

2020-Current year OA Pubs

Approximately 80% of invasive breast cancers are classified as human epidermal growth factor receptor 2 (HER2)-negative; however, many of these tumors have detectable levels of HER2 surface expression. Trastuzumab deruxtecan (T-DXd) is a HER2-directed antibody-drug conjugate with a membrane-permeable payload that is cytotoxic to both HER2-expressing tumor cells and neighboring cells via the bystander antitumor effect. T-DXd has shown significant antitumor activity in clinical trials for patients with HER2-positive (immunohistochemistry [IHC] 3+ or IHC 2+/in situ hybridization [ISH]+) breast cancer. In addition, the results of the DESTINY-Breast04 trial demonstrated the clinical benefit of T-DXd in patients with HER2-low (IHC 1+ …


The Holy Spirit As A Representative Of Christ In Ellen G. White’S Writings, Denis Kaiser Dec 2025

The Holy Spirit As A Representative Of Christ In Ellen G. White’S Writings, Denis Kaiser

Ellen White Issues Symposium

No abstract provided.


Healing Through History, Nancy Baker Jones Dec 2025

Healing Through History, Nancy Baker Jones

Journal of Texas History

This is the written transcription of the author’s closing plenary address to the inaugural conference of the Alliance for Texas History, May 17, 2025. Its purpose is to put into both broad and personal historical contexts the events of 2023 and 2024 that led to the founding of the Alliance for Texas History. It concludes that, despite the difficulties of those events for her and for many other historians of Texas, history offers a potentially healing context for moving forward.