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Thinking Machines: Cybernetics, Artificial Intelligence, And Technological Anxiety In The American Cold War, Erin Mae Wilcox Jan 2026

Thinking Machines: Cybernetics, Artificial Intelligence, And Technological Anxiety In The American Cold War, Erin Mae Wilcox

Theses and Dissertations

Following the Second World War, cybernetics emerged as a cross-disciplinary study in philosophy, neurophysiology, electrical engineering, and mathematics. Cyberneticists proposed the formal study of the man-machine analogy; that is, to equate biological structures to a complex mechanical system. Drawing from this analogy, cyberneticists used programmable digital computers to emulate the functions of the human brain. The study of artificial intelligence emerged within this cybernetic discourse in the early 1950s; yet, by the mid-1960s, the two disciplines suffered a methodological fracture. Drawing from a tradition generated by this fracture, historians have traditionally examined cybernetics and artificial intelligence in isolation from one …


Predicting Job Performance: The Incremental Validity Of Cognitive Reflection Tests Over General Cognitive Ability And Conscientiousness., Olivia Earll Jan 2026

Predicting Job Performance: The Incremental Validity Of Cognitive Reflection Tests Over General Cognitive Ability And Conscientiousness., Olivia Earll

Theses and Dissertations

Cognitive reflection is the ability to suppress intuitive thinking (Type 1) in favor of deliberative, analytical thought (Type 2). This study investigated cognitive reflection as a predictor of supervisor-rated job performance, exploring its incremental validity over general cognitive ability and conscientiousness. Results indicated that all three variables positively predicted job performance, with cognitive reflection explaining a significant, unique portion of the variance. Exploratory analyses confirmed that this predictive validity remained consistent across industry, age, and sex. Furthermore, cognitive reflection significantly moderated the relationship between general cognitive ability and job performance. These findings highlight the value of deliberative reasoning as a …


Data Defines Success: Algorithm For Dataset Quality Assessment In Deep Learning For Malware Detection, Matei Ionescu Jan 2026

Data Defines Success: Algorithm For Dataset Quality Assessment In Deep Learning For Malware Detection, Matei Ionescu

Theses and Dissertations

The field of artificial intelligence is based upon the premise of constructing architectures through which to propagate training data. However, the majority of existing research literature is focused on architecture. While necessary, the attention devoted to the architecture should not so precipitously exceed that of the data. It should be noted that this disparity is not without reasonable cause. Data quality is often exceedingly difficult to verify due to particularities of the field or subfield; LLM repositories of text are distinct from image recognition pictures of dog breeds which are distinct from EEG waveforms of human brains which are distinct …


Fostering A Growth Mindset In Mathematics: Faculty And Student Experiences, Yolanda G. Rush Jan 2026

Fostering A Growth Mindset In Mathematics: Faculty And Student Experiences, Yolanda G. Rush

Theses and Dissertations

According to the Center for Community College Student Engagement (2019), many students attending two-year institutions need productive persistence strategies, including the development of a growth mindset. Although some growth mindset interventions have been effective in improving academic achievement among students (Boaler, 2016; Canning et al., 2024) and persistence (Lewis, 2019) among students, especially those with developmental needs (Suh et al., 2019) and those in mathematics, little is known about the experiences of students and teachers (i.e., students’ perceptions of teachers’ intentions and implementation) as teachers work to foster a growth mindset culture (Murphy et al., 2021). In this dissertation, I …


Rhetoric Of Realignment: An Analysis Of Trump's 2024 Campaign Rhetoric, David Valadez Jan 2026

Rhetoric Of Realignment: An Analysis Of Trump's 2024 Campaign Rhetoric, David Valadez

Theses and Dissertations

When political coalitions include groups with opposing policy goals, leaders face a challenge: satisfying all constituencies without making commitments that alienate essential supporters. The present study examines strategic ambiguity in the form of deliberately vague political messaging as a tool for managing this challenge. Combining rhetorical analysis with selectorate theory, which explains how leaders achieve and maintain power through reward distribution, the research analyzes Donald Trump’s 2024 Republican National Convention acceptance speech, focusing on immigration rhetoric.

The analysis reveals that Trump’s ambiguity was selective rather than habitual. On immigration, where tech/corporate interests wanting skilled workers clashed with nationalist groups demanding …


Staff Attitudes Toward Ai Adoption At A Private Research University, Ashley C. Smith Jan 2026

Staff Attitudes Toward Ai Adoption At A Private Research University, Ashley C. Smith

Theses and Dissertations

This study addresses the limited research on university staff attitudes toward artificial intelligence use and adoption. Using the Unified Theory of Acceptance and Use of Technology (UTAUT) research framework, the General Attitudes towards Artificial Intelligence Scale (GAAIS), and quantitative survey methodology, the study examines the attitudes of higher education staff toward AI, specifically examining whether demographic or professional characteristics are factors. The findings indicate that staff had moderately negative attitudes toward AI while also expressing some concerns. The results suggest that more resources and support for AI are needed for staff to address concerns. It also suggests that construct-level analysis …


Constructing And Deconstructing Homelessness: Challenging The Stigmatization Of The Unhoused Through Lived Experience, Brenna Jones Jan 2026

Constructing And Deconstructing Homelessness: Challenging The Stigmatization Of The Unhoused Through Lived Experience, Brenna Jones

Theses and Dissertations

As homelessness rises across the United States, public discourse plays an important role in shaping how the housing crisis is understood and addressed. This study examines how homelessness is constructed through local media narratives and how these constructions shape the experiences of unhoused individuals. Using a case study of Greater Bangor, Maine, this research combines a critical content analysis of 315 news articles from the Bangor Daily News (2020-2025) with in-depth interviews with 18 unhoused and precariously housed individuals. The findings demonstrate how media portrayals construct homelessness as a stigmatized identity associated with disorder, addiction, and danger. These narratives contribute …


Middle School Students' Initial Ideas And Their Connections In Proportion Word Problems, Carrie Ann Lawton Jan 2026

Middle School Students' Initial Ideas And Their Connections In Proportion Word Problems, Carrie Ann Lawton

Theses and Dissertations

In this dissertation study, I sought to identify the initial ideas that middle school students had when approaching Multiple Batches and Variable Parts proportion word problems, as well as the connections they made among those initial ideas. I conducted semi-structured individual and paired interviews with 13 sixth- and seventh-grade students at the end of their school year. I then used the Knowledge-in-Pieces theoretical perspective to identify knowledge resources that the participants accessed when approaching the tasks, prior to any intervention on my part.

Through my analysis, I identified 18 initial ideas that the middle school students employed when solving the …


Examination Of The Effects Aesthetic Enrichment And Music Have On Well-Being And Task Performance In A Workplace Simulation, Emily Budik Jan 2026

Examination Of The Effects Aesthetic Enrichment And Music Have On Well-Being And Task Performance In A Workplace Simulation, Emily Budik

Theses and Dissertations

Workplace environments are often designed with a focus on efficiency, yet emerging research suggests that environmental features such as aesthetic enrichment and music may influence employee well-being and performance. The present study examined whether visual aesthetic enrichment and auditory stimulation through music could improve well-being, reduce stress, and enhance task performance within a simulated workplace task. Participants completed a 30-minute in-basket task under one of four conditions: a control environment, music only, aesthetic enrichment only, or a combined aesthetic enrichment and music condition. Measures of stress, well-being, and task performance were collected following task completion. Results indicated that neither aesthetic …


Data Utilization In Facilities’ Performance Management Decision- Making At U.S. Four-Year Public Institutions: A Cross-Sectional Exploratory Study, Tanaporn Supanichrattana Jan 2026

Data Utilization In Facilities’ Performance Management Decision- Making At U.S. Four-Year Public Institutions: A Cross-Sectional Exploratory Study, Tanaporn Supanichrattana

Theses and Dissertations

The growing complexity of higher education finance, aging infrastructure, and rising accountability expectations has intensified demands on facilities organizations to manage institutional assets strategically. As colleges and universities face sustained fiscal constraints and expanding operational pressures, the ability of facilities leaders to use data to inform performance management has become increasingly critical. Despite this importance, limited empirical research has examined how facilities leaders integrate data into decision-making within public higher education contexts.

The quantitative study employed a cross-sectional, exploratory survey design to investigate data utilization practices among facilities leaders at U.S. public four-year institutions. Guided by the Data–Information–Knowledge–Wisdom hierarchy and …


The Acculturation Of International-Born Student Affairs Administrators In The United States, Amber Joy Webb Jan 2026

The Acculturation Of International-Born Student Affairs Administrators In The United States, Amber Joy Webb

Theses and Dissertations

This qualitative narrative study explored how international student affairs administrators in the United States experience acculturation. Guided by Berry’s (1997) fourfold model of acculturation, the study examined how participants experienced assimilation, integration, separation, and marginalization as they navigated their professional roles, institutional expectations, and cultural identities. Eight participants, representing diverse countries of origin, institutional types, and professional roles, were interviewed using a semi-structured interview guide. Data were analyzed using Braun and Clarke's (2006) framework. Findings indicated participants employed multiple, context-dependent acculturation strategies rather than adhering to a single strategy. Assimilation emerged as a strategic process for establishing professional legitimacy, navigating …


First- And Second-Generation Immigrant Emerging Adults’ Career Aspirations, Laura A. Botros Jan 2026

First- And Second-Generation Immigrant Emerging Adults’ Career Aspirations, Laura A. Botros

Theses and Dissertations

Despite first- and second-generation immigrants making up 19.6% of the U.S. workforce (U.S. Bureau of Labor Statistics, 2024), research exploring their career aspirations is scarce. Studies show that individuals’ cultural backgrounds significantly shape first- and second-generation immigrants' career aspirations, values, and professional goals (Kao, 2004; Polenova et al., 2017). The purpose of the study is to examine how first- and second-generation immigrant emerging adults' cultural backgrounds inform their career aspirations. I utilized a qualitative approach by asking participants about their cultural background, career aspirations, and what influenced their career aspirations. Interviews and a cognitive map activity were conducted to investigate …


"I Didn't Teach It Again Because It Wasn't Worth It": How Grades 6-12 English Language Arts Teachers Select Texts And Navigate The Obstacles That Impede Them, Steve Poggendorf Jan 2026

"I Didn't Teach It Again Because It Wasn't Worth It": How Grades 6-12 English Language Arts Teachers Select Texts And Navigate The Obstacles That Impede Them, Steve Poggendorf

Theses and Dissertations

Classroom texts not only function as tools through which teachers can build curricula, but they can also engage and empower learners. Despite the importance of engaging texts in the classroom, teachers encounter obstacles, both social and institutional, that impede their ability to select the texts they believe will best foster student engagement and empowerment. The purpose of this qualitative study was to investigate how teachers make text selections, as well as the nature of the obstacles that stand in the way of teachers who hope to inspire and engage their students through lessons built around texts of their choosing. The …


Adherence And Compliance With Exercise Training In Progressive Multiple Sclerosis: Rates And Correlates From The Cogex Trial, Cogex Research Team, Robert W. Motl, Andrew Argie, Roberto S. Hernandez, Brian M. Sandroff, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Maria A. Rocca, Amber Salter, Anthony Feinstein Jan 2026

Adherence And Compliance With Exercise Training In Progressive Multiple Sclerosis: Rates And Correlates From The Cogex Trial, Cogex Research Team, Robert W. Motl, Andrew Argie, Roberto S. Hernandez, Brian M. Sandroff, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Maria A. Rocca, Amber Salter, Anthony Feinstein

School of Health Professions

Background: There is limited understanding of adherence and compliance rates for exercise training(ET) in people with progressive multiple sclerosis(PMS).Objectives: This secondary, exploratory data analysis examined rates of adherence and compliance for continuous, moderate intensity training and high-intensity intervaltraining(HIIT) and possible correlates among people with PMS from the CogEx trial.Methods: CogEx was a multi-site, multi-arm, randomized, double-blinded, and shamcontrolled trial undertaken by 11 sites in six di8erent countries. Participants(N=311) wererandomized into one of four conditions with di8erent combinations of ET and cognitive rehabilitation, including respective sham conditions, delivered twice weekly over 12 weeks.The analysis focused on adherence and compliance rates and …


Connecting The Dots - Recognition Of Artificial And Natural Shapes Relies On Representing Points Of High Information, Gunnar Schmidtmann, Nicholas Baker, Kevin J. Lande, Filipp Schmidt Jan 2026

Connecting The Dots - Recognition Of Artificial And Natural Shapes Relies On Representing Points Of High Information, Gunnar Schmidtmann, Nicholas Baker, Kevin J. Lande, Filipp Schmidt

School of Health Professions

Physiological and psychophysical evidence suggests that the visual system represents object outlines using prominent curvature features, particularly regions of extreme curvature (convex maxima and concave minima). These curvature extrema often coincide with points of high informational content (“surprisal”), but this relationship is only correlational. It remains unclear whether the visual system explicitly encodes curvature extrema or instead prioritizes the most informative contour locations. To address this, we conducted two shape-matching experiments comparing the roles of curvature extrema and surprisal in shape representation. Observers performed match-to-sample tasks in which smooth reference shapes were matched to simplified polygonal versions created by connecting …


Once-Weekly Navepegritide In Children With Achondroplasia: The Approach Randomized Clinical Trial, Ravi Savarirayan, Ciara Mcdonnell, Carlos A Bacino, Daniel G Hoernschemeyer, Janet M Legare, M Jennifer Abuzzahab, Paul L Hofman, Philippe M Campeau, Josep Maria De Bergua Domingo, Leanne M Ward, Kevin Smit, Alden Smith, Meng Mao, Michael S Ominsky, Lærke C Freiberg, Aimee D Shu, Hanne B Hove Jan 2026

Once-Weekly Navepegritide In Children With Achondroplasia: The Approach Randomized Clinical Trial, Ravi Savarirayan, Ciara Mcdonnell, Carlos A Bacino, Daniel G Hoernschemeyer, Janet M Legare, M Jennifer Abuzzahab, Paul L Hofman, Philippe M Campeau, Josep Maria De Bergua Domingo, Leanne M Ward, Kevin Smit, Alden Smith, Meng Mao, Michael S Ominsky, Lærke C Freiberg, Aimee D Shu, Hanne B Hove

Faculty, Staff and Students Publications

Importance: Historically considered a skeletal dysplasia characterized by disproportionate short stature, achondroplasia is a condition with multisystemic effects due to the widespread expression of the fibroblast growth factor receptor 3 variant throughout the body, impacting muscle, neurological function, cardiorespiratory health, and health-related quality of life.

Objective: To evaluate the efficacy, safety, and tolerability of once-weekly navepegritide, an investigational prodrug of C-type natriuretic peptide, while assessing benefits beyond growth that may have important implications for complications and health-related quality of life in children with achondroplasia.

Design, setting, and participants: Enrollment for this pivotal phase 2b, randomized, double-blind, placebo-controlled trial (APPROACH) was …


The Words Community Dwelling, Spanish-Preferring Mexican/Mexican American Adults Use To Talk About Alzheimer’S Disease And Genetic Testing: Implications For Education And Outreach, Jamie C Fong, Fatima I Chavez, Karla Silos, Mirna L Arroyo-Miranda, Gabriela Castro Castro, Mark E Kunik, Joshua M Shulman, Luis D Medina Jan 2026

The Words Community Dwelling, Spanish-Preferring Mexican/Mexican American Adults Use To Talk About Alzheimer’S Disease And Genetic Testing: Implications For Education And Outreach, Jamie C Fong, Fatima I Chavez, Karla Silos, Mirna L Arroyo-Miranda, Gabriela Castro Castro, Mark E Kunik, Joshua M Shulman, Luis D Medina

Faculty, Staff and Students Publications

Introduction: Hispanic/Latino (H/L) adults are more likely than non-Hispanic White individuals to have Alzheimer's disease (AD), yet fewer than one in five H/L adults has apolipoprotein E (APOE) Ɛ4, underscoring gaps in understanding genetic risk across H/L heritage groups. H/L adults remain underrepresented in AD research that uses genetic data for participant stratification. To inform culturally appropriate educational materials for 16 million U.S. Spanish speakers, we identified culturally salient words Spanish-preferring H/L adults use to describe AD and genetic testing beyond APOE.

Methods: Community-residing, Spanish-preferring Mexican/Mexican American adults (n = 14) completed freelisting interviews, a method eliciting …


Amino Acids And Lean Mass Accretion In Preterm Neonates, Antonio C Ramos Dos Santos, Marta L Fiorotto, Teresa A Davis Jan 2026

Amino Acids And Lean Mass Accretion In Preterm Neonates, Antonio C Ramos Dos Santos, Marta L Fiorotto, Teresa A Davis

Faculty, Staff and Students Publications

Purpose of review: This review evaluates recent evidence on how total protein and energy intake, amino acid composition, and nutrient delivery modality influence protein synthesis in preterm neonates, with the goal of informing nutritional strategies to support optimal lean mass accretion and growth.

Recent findings: Preterm neonates exhibit anabolic resistance to feeding due to impaired insulin and amino acid signaling in skeletal muscle. Enteral nutrition, especially fortified human milk, supports better lean mass accretion and neurodevelopment than parenteral nutrition. Intermittent bolus feeding and pulsatile leucine supplementation during continuous feeding further enhance mTORC1-dependent translation initiation signaling and protein synthesis efficiency in …


Reclaiming Sophia In The Age Of Ai: Theological And Ethical Reflections On Consecrated Technology And Human Dignity, Matthew H. Sauber Jan 2026

Reclaiming Sophia In The Age Of Ai: Theological And Ethical Reflections On Consecrated Technology And Human Dignity, Matthew H. Sauber

Faculty Scholarship 2026

The cultural emergence of artificial intelligence systems named after figures of divine wisdom—most notably the Hanson Robotics humanoid Sophia, granted Saudi citizenship in 2017—reveals a gap between the language of the wisdom traditions and that of contemporary technology. This paper treats that gap as the occasion for theological and ethical reflection on AI. Drawing on the Sophia tradition across its Hebrew, Hellenistic-Patristic, Gnostic, Russian Sophiological, perennialist, and Sufi articulations—especially Sergei Bulgakov’s account of Sophia as mediation between divine wisdom and created order—it develops a framework termed Consecrated Technology. The argument unfolds in three moves: (1) a structural critique showing how …


In Vivo Volumetric Visualization And Quantification Of Cumulus Expansion In Mice With Intravital Optical Coherence Tomography, Kohei Umezu, Frank J Brooks, Irina Larina Jan 2026

In Vivo Volumetric Visualization And Quantification Of Cumulus Expansion In Mice With Intravital Optical Coherence Tomography, Kohei Umezu, Frank J Brooks, Irina Larina

Faculty, Staff and Students Publications

Ovulation is preceded by a critical physiological process known as cumulus expansion, during which the cumulus cell layer surrounding the oocyte undergoes structural remodeling. Despite the recognized importance of this process for reproductive success, live quantitative imaging of cumulus expansion has not been previously achieved due to limitations of current imaging technologies for deeply located ovaries. In this study, we employed intravital optical coherence tomography for three-dimensional visualization of mouse follicles containing cumulus-oocyte complexes (COC) within the physiological context of the ovary, both ex vivo and in vivo. This method enabled time-lapse measurement of cumulus layer thickness and COC …


Astrocytic Sox9 Overexpression In Alzheimer’S Disease Mouse Models Promotes Aβ Plaque Phagocytosis And Preserves Cognitive Function, Dong-Joo Choi, Sanjana Murali, Wookbong Kwon, Junsung Woo, Eun-Ah Christine Song, Yeunjung Ko, Debosmita Sardar, Brittney Lozzi, Yi-Ting Cheng, Michael R Williamson, Teng-Wei Huang, Kaitlyn Sanchez, Joanna Jankowsky, Benjamin Deneen Jan 2026

Astrocytic Sox9 Overexpression In Alzheimer’S Disease Mouse Models Promotes Aβ Plaque Phagocytosis And Preserves Cognitive Function, Dong-Joo Choi, Sanjana Murali, Wookbong Kwon, Junsung Woo, Eun-Ah Christine Song, Yeunjung Ko, Debosmita Sardar, Brittney Lozzi, Yi-Ting Cheng, Michael R Williamson, Teng-Wei Huang, Kaitlyn Sanchez, Joanna Jankowsky, Benjamin Deneen

Faculty, Staff and Students Publications

Astrocytes play essential roles in the brain, and their dysfunction is associated with nearly every form of neurological disease. Despite their ubiquity, knowledge of how astrocytes contribute to disease pathogenesis is incomplete; accordingly, harnessing their biology toward therapeutics remains a major challenge. Here we show that the transcription factor Sox9 plays a context-specific role in maintaining astrocyte function and circuit activity in the aging hippocampus and Alzheimer's disease (AD) models. We found that Sox9 overexpression in astrocytes in AD models clears existing amyloid beta (Aβ) plaques and preserves cognitive function. Mechanistically, Sox9 promotes the phagocytosis of Aβ plaques by astrocytes …


Predictors Of Inpatient Rn Turnover In Rural And Urban Vha Hospitals, Katherine G Bay, Chase S Eck, Melissa K Knox, Paras Mehta, Laura A Petersen Jan 2026

Predictors Of Inpatient Rn Turnover In Rural And Urban Vha Hospitals, Katherine G Bay, Chase S Eck, Melissa K Knox, Paras Mehta, Laura A Petersen

Faculty, Staff and Students Publications

Background: The rising demand for health care delivery and an aging workforce is of particular concern in rural areas, where health care access depends upon an adequate nursing workforce. To address this shortage and optimize care, it is essential to measure when registered nurses (RN) leave inpatient direct care positions (ie, inpatient RN turnover) and identify modifiable factors correlated with RN turnover.

Objectives: Apply a novel method for characterizing inpatient RN turnover to understand factors associated with variation in RNs leaving inpatient positions at rural and urban Veterans Health Administration (VHA) hospitals.

Project design: Retrospective cohort study.

Subjects: Direct care …


Duration Of Antimicrobial Therapy In Cardiovascular Implantable Electronic Device Associated Systemic Infections: A Retrospective Analysis, Emily Y Xiao, Patrick T Lynch, Sarwat Khalil, Derrick A Draeger, Alexandra M Lewis, Faiz M Baqai, Mihail G Chelu, M Rizwan Sohail Jan 2026

Duration Of Antimicrobial Therapy In Cardiovascular Implantable Electronic Device Associated Systemic Infections: A Retrospective Analysis, Emily Y Xiao, Patrick T Lynch, Sarwat Khalil, Derrick A Draeger, Alexandra M Lewis, Faiz M Baqai, Mihail G Chelu, M Rizwan Sohail

Faculty, Staff and Students Publications

Background: While the need for complete device removal is well-established for cardiovascular implantable electronic device (CIED) infections, there is insufficient evidence on the optimal duration of antimicrobial therapy.

Objectives: To examine how antimicrobial duration affects clinical outcomes of patients presenting with CIED-associated bacteremia and lead endocarditis.

Design: This is a retrospective cohort study conducted at a quaternary care hospital in Houston, TX, USA.

Methods: Patients who underwent device removal for a primary indication of bacteremia or lead endocarditis over a 10-year period were stratified by prescribed duration of antibiotics as ⩽2 weeks or >2 weeks post-extraction. Measured outcomes included all-cause …


Modulation Of Corneal Sensory Processing And Pain Responses By Dry Eye And Corneal Wounding, Ebru Yaman, Yangluowa Qu, Kaylin C Arpaia, Fairouz Elsaeidi, Uma Lakshmi Balakrishnan, Lance He, Henry Skrehot, Jehan Alam, Rui Chen, Mary Ann Stepp, Cintia S De Paiva, Stephen C Pflugfelder Jan 2026

Modulation Of Corneal Sensory Processing And Pain Responses By Dry Eye And Corneal Wounding, Ebru Yaman, Yangluowa Qu, Kaylin C Arpaia, Fairouz Elsaeidi, Uma Lakshmi Balakrishnan, Lance He, Henry Skrehot, Jehan Alam, Rui Chen, Mary Ann Stepp, Cintia S De Paiva, Stephen C Pflugfelder

Faculty, Staff and Students Publications

Background: Dry eye disease (DED) is a multifactorial disorder of the ocular surface in which tear film instability, epithelial barrier disruption, and neurosensory dysfunction contribute to symptom generation. Although several contributing factors have been identified, how different forms of ocular surface stress affect sensory pathways and behavioral responses remains unclear.

Purpose: This study aimed to evaluate corneal barrier function, sensory responses, and pain-related behaviors across acute and chronic dry eye and corneal injury models, and to assess stimulus-specific responses associated with TRPV1 and TRPM8 mediated pathways.

Methods: Female C57BL/6 J wild type and Mmp9KO mice were evaluated in acute desiccating …


Microbial Collagenase Activity Is Linked To Oral–Gut Translocation In Advanced Chronic Liver Disease, Shen Jin, Aurelie Cenier, Daniela Wetzel, Bethlehem Arefaine, Mar Moreno-Gonzalez, Marilena Stamouli, Merianne Mohamad, Mariia Lupatsii, Emilio Ríos, Sunjae Lee, Ane Zamalloa, Shilpa Chokshi, Adil Mardinoglu, Saeed Shoaie, Naiara Beraza, Vishal C. Patel, Melanie Schirmer Jan 2026

Microbial Collagenase Activity Is Linked To Oral–Gut Translocation In Advanced Chronic Liver Disease, Shen Jin, Aurelie Cenier, Daniela Wetzel, Bethlehem Arefaine, Mar Moreno-Gonzalez, Marilena Stamouli, Merianne Mohamad, Mariia Lupatsii, Emilio Ríos, Sunjae Lee, Ane Zamalloa, Shilpa Chokshi, Adil Mardinoglu, Saeed Shoaie, Naiara Beraza, Vishal C. Patel, Melanie Schirmer

Peninsula Medical School

Microbiome perturbations are associated with advanced chronic liver disease (ACLD), but how microorganisms contribute to disease mechanisms is unclear. Here we analysed metagenomes of paired saliva and faecal samples from an ACLD cohort of 86 individuals, plus 2 control groups of 52 healthy individuals and 14 patients with sepsis. We identified highly similar oral and gut bacterial strains, including Veillonella and Streptococcus spp., which increased in absolute abundance in the gut of patients with ACLD compared with controls. These microbial translocators uniquely share a prtC gene encoding a collagenase-like proteinase, and its faecal abundance was a robust ACLD biomarker (area …


Efficacy And Safety Of Pyrimidine Nucleos(T)Ide Therapy In Thymidine Kinase 2 Deficiency, Michio Hirano, Caterina Garone, Richard Haas, Carmen Paradas, Fernando Scaglia, Irene Rebollo Mesa, Carl Chiang, Anny-Odile Colson, Susan Vanmeter, Cristina Domínguez-González Jan 2026

Efficacy And Safety Of Pyrimidine Nucleos(T)Ide Therapy In Thymidine Kinase 2 Deficiency, Michio Hirano, Caterina Garone, Richard Haas, Carmen Paradas, Fernando Scaglia, Irene Rebollo Mesa, Carl Chiang, Anny-Odile Colson, Susan Vanmeter, Cristina Domínguez-González

Faculty, Staff and Students Publications

Thymidine kinase 2 deficiency (TK2d) (MIM 609560) is an ultra-rare, autosomal recessive mitochondrial myopathy caused by TK2 variants, leading to mitochondrial DNA depletion and/or multiple deletions. People with thymidine kinase 2 deficiency experience progressive myopathy, bulbar weakness and respiratory insufficiency, often losing the ability to walk, eat and breathe independently. Doxecitine and doxribtimine represents the first approved treatment for patients with thymidine kinase 2 deficiency with age of symptom onset ≤12 years by the US Food and Drug Administration and the European Medicines Agency; previously, disease management was limited to supportive care. We investigated the efficacy and safety of pyrimidine …


Test-Retest Apparent Diffusion Coefficient Reproducibility In Head And Neck Cancer Using A 15-T Mr-Linac, Brigid A Mcdonald, Dina El-Habashy, Renjie He, Sam Mulder, Sarah Mirbahaeddin, Abdallah S R Mohamed, Sara Ahmed, Yao Ding, Jihong Wang, Stephen Y Lai, Alex Dresner, John Christodouleas, Clifton D Fuller Jan 2026

Test-Retest Apparent Diffusion Coefficient Reproducibility In Head And Neck Cancer Using A 15-T Mr-Linac, Brigid A Mcdonald, Dina El-Habashy, Renjie He, Sam Mulder, Sarah Mirbahaeddin, Abdallah S R Mohamed, Sara Ahmed, Yao Ding, Jihong Wang, Stephen Y Lai, Alex Dresner, John Christodouleas, Clifton D Fuller

Faculty, Staff and Student Publications

Purpose

To evaluate the reproducibility of apparent diffusion coefficient (ADC) measurements in head and neck squamous cell carcinoma (HNSCC) using a 1.5-T MR-linac (MRI-guided linear accelerator) system.

Materials and Methods

In this retrospective study, conducted between February 2021 and January 2024, patients with HNSCC lesions underwent echo-planar imaging diffusion-weighted MRI on a 1.5-T MR-linac system at two time points before the start of radiation therapy. Mean and median ADC values and volumes were measured for each lesion. Absolute and percent reproducibility coefficients (RCs) were calculated. Linear regression analyses and F tests were performed to determine whether the lesion volume or …


Examining Links Between Somatosensation And Cognition In Children With Hemiplegic Cerebral Palsy, Kassandra M. Hewitt, Donna M. Bayliss, Belinda A. Mclean, Ashleigh L. Thornton, Jonson J. Moyle Jan 2026

Examining Links Between Somatosensation And Cognition In Children With Hemiplegic Cerebral Palsy, Kassandra M. Hewitt, Donna M. Bayliss, Belinda A. Mclean, Ashleigh L. Thornton, Jonson J. Moyle

Research outputs 2022 to 2026

Children with cerebral palsy (CP) are at increased risk of impaired somatosensation and cognition. Among children with hemiplegia, approximately three-quarters have impaired somatosensation and one-third have intellectual impairment. While somatosensation may relate to cognitive functioning in CP, this relationship has not previously been investigated. This cross-sectional study examined the relationship between somatosensation and cognition in children with hemiplegic CP, and whether the pattern of brain injury, classified using an established MRI classification system, moderates this relationship. Forty-seven children (26 females) with hemiplegic CP participated (mean age = 11.0 years; SD = 3.6; range: 6–16 years). Parent questionnaires provided demographic, educational, …


Evaluating The Role Of Power Electronics In Enhancing Renewable Energy And Smart Grid Performance: A Review, Muhammad Irfan Habib Jan 2026

Evaluating The Role Of Power Electronics In Enhancing Renewable Energy And Smart Grid Performance: A Review, Muhammad Irfan Habib

ASEAN Journal on Science and Technology for Development

The review article demonstrates the importance of power electronics in propelling the increase of renewables and increasing the efficiency of contemporary electrical grids. In particular, it highlights the need for bidirectional converters for effective energy management in vehicle-to-grid (V2G) systems with two-way power transfer. The paper examines the series of complications offered by the significantly large integration of power electronic converter-interfaced renewables, such as those related to system steadiness, power quality, and resignation bottlenecks. Also, it recognizes a mix of new technologies, such as wide bandgap (WBG) semiconductors like silicon carbide (SiC) and gallium nitride (GaN), that deliver superior performance …


Systematic Study On Preparation And Characterizations Of High Performance Bimetallic Pt-Co/Sba-15 Catalyst In N-Heptane Isomerization, Talib M. Albayati, Khalid A. Sukkar, Nisreen S. Ali, Mahir A. Abdulrahman, Basheer A. Abdulhussein, Issam K. Salih, Narges Elmi Fard Jan 2026

Systematic Study On Preparation And Characterizations Of High Performance Bimetallic Pt-Co/Sba-15 Catalyst In N-Heptane Isomerization, Talib M. Albayati, Khalid A. Sukkar, Nisreen S. Ali, Mahir A. Abdulrahman, Basheer A. Abdulhussein, Issam K. Salih, Narges Elmi Fard

ASEAN Journal on Science and Technology for Development

Bimetallic catalysts were prepared by deposition of 1% of loading of (Pt-Co) onto SBA 15 support using heterogeneous reaction for enhancing hydroisomerization and promoting hydrocracking for the decomposition of n-heptane. The catalytic performance of the catalysts was subsequently evaluated thereafter. Characterization of the prepared catalysts was done by various techniques, which include XRD, FTIR, BETBJH, SEM/EDS, and TEM. The temperature range studied for this catalytic activity was 250 to 400 °C, at atmospheric pressure in a plug-flow reactor. The experimental setup kept a very rigorous control over the temperature, flow rate for the reactants, and pressure, while gas chromatographic techniques …