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Disease Modeling And Disease Gene Discovery In Cardiomyopathies: A Molecular Study Of Induced Pluripotent Stem Cell Generated Cardiomyocytes, Satish Kumar, Joanne E. Curran, Kashish Kumar, Erica De Leon, Ana C. Leandro, Juan M. Peralta, Sarah Williams-Blangero, John Blangero Mar 2021

Disease Modeling And Disease Gene Discovery In Cardiomyopathies: A Molecular Study Of Induced Pluripotent Stem Cell Generated Cardiomyocytes, Satish Kumar, Joanne E. Curran, Kashish Kumar, Erica De Leon, Ana C. Leandro, Juan M. Peralta, Sarah Williams-Blangero, John Blangero

School of Medicine Publications

The in vitro modeling of cardiac development and cardiomyopathies in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) provides opportunities to aid the discovery of genetic, molecular, and developmental changes that are causal to, or influence, cardiomyopathies and related diseases. To better understand the functional and disease modeling potential of iPSC-differentiated CMs and to provide a proof of principle for large, epidemiological-scale disease gene discovery approaches into cardiomyopathies, well-characterized CMs, generated from validated iPSCs of 12 individuals who belong to four sibships, and one of whom reported a major adverse cardiac event (MACE), were analyzed by genome-wide mRNA sequencing. The …

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Age-Related Differences In Functional Tool-Use Are Due To Changes In Movement Quality And Not Simply Motor Slowing, Andrew Hooyman, Peiyuan Wang, Sydney Y. Schaefer Mar 2021

Age-Related Differences In Functional Tool-Use Are Due To Changes In Movement Quality And Not Simply Motor Slowing, Andrew Hooyman, Peiyuan Wang, Sydney Y. Schaefer

Physical Therapy Faculty Articles and Research

Age-related declines in fine motor control may impact tool-use and thereby limit functional independence. Most previous research has, however, focused on the effect of aging on gross motor tasks. Few studies have investigated the effects of aging on the strategy or quality of fine motor skills, especially in tool-use, which may better reflect how age impacts complex movement capability. Twenty-two young (ages 19–35) and 18 older adults (ages 58–87) performed a timed upper extremity task using a tool to acquire and transport objects to different locations. Overall task performance was divided into two phases based on 3-D position of the …

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Calculating Privacy Preserving Reach Using Hyperloglog Sketches, Jason Frye, Benjamin Kreuter, Trancrede Lepoint, Craig Wright Mar 2021

Calculating Privacy Preserving Reach Using Hyperloglog Sketches, Jason Frye, Benjamin Kreuter, Trancrede Lepoint, Craig Wright

Defensive Publications Series

Methods for measuring cross media content exposure across multiple publishers in a privacy preserving way are disclosed. The solutions described can accommodate publishing platforms that vary in size and computational resources without hindering performance or accuracy. Proposed is a solution to implement a privacy-safe HyperLogLog sketch implementation that can be applied to the cross media content exposure problem, as well as other problems that require privacy safe multi-set cardinality estimation. The processes described herein include publishers constructing encrypted HyperLogLog sketches and transmitting the encrypted sketches to worker computing devices, the worker computing devices joining the encrypted sketches, the worker computing …

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Table Of Contents & Masthead, Zachary R. Carstens Mar 2021

Table Of Contents & Masthead, Zachary R. Carstens

Pepperdine Law Review

No abstract provided.

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The New Era Of Nfl Antitrust Law, The Sunday Ticket Package: Was The Ninth Circuit Ruling A Touchdown Or A Penalty?, Maya Rustom Mar 2021

The New Era Of Nfl Antitrust Law, The Sunday Ticket Package: Was The Ninth Circuit Ruling A Touchdown Or A Penalty?, Maya Rustom

Pepperdine Law Review

Americans love football, but every year thousands of fans are forced to pay exorbitant annual fees if they chose to have access to out-of-market games. In other words, if fans don’t live in the territory of their favorite team, they can either pay an excessive annual fee to watch their team play or miss out on the majority of games every season. This arrangement is a result of DirecTV’s Sunday Ticket Package, which is an exclusive distributorship agreement with the NFL that prevents fans from watching live out-of-market games unless they pay the annual subscription fee. This Comment addresses and …

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Blurred Lines: How To Rationally Understand The “Rational Understanding” Doctrine After Madison V. Alabama, Cassidy Young Mar 2021

Blurred Lines: How To Rationally Understand The “Rational Understanding” Doctrine After Madison V. Alabama, Cassidy Young

Pepperdine Law Review

In Madison v. Alabama, the Supreme Court held that a capital inmate’s inability to remember his crime did not render him incompetent to be executed. The Court reasoned that an individual who suffers from episodic memory loss may still “rationally understand” society’s reasons for sentencing him to death for a crime he once committed. This Note explores the impact of memory loss on a person’s self-identity, and consequently challenges the notion that a capital inmate who no longer remembers his crime can truly have a rational understanding of it. Specifically, this Note examines how memory loss substantially weakens the two …

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Professional Experience, Sarah Moss Mar 2021

Professional Experience, Sarah Moss

The Voice

No abstract provided.

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Hard On Ideas, Soft On People, Erik Hoekstra Mar 2021

Hard On Ideas, Soft On People, Erik Hoekstra

The Voice

No abstract provided.

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Historic Artifacts And The Buzzard Cult In Florida, John W. Griffin Mar 2021

Historic Artifacts And The Buzzard Cult In Florida, John W. Griffin

Florida Historical Quarterly

An extensive literature on the archaeology of Florida has been amassed over a considerable number of years. By far the greater part of this literature is purely descriptive, and it is the purpose of this paper to take some of the older materials and interpret them in the light of current archaeological knowledge; knowledge which has advanced at an almost breathtaking rate in the past decade. For our purposes we shall select seven related artifacts from southern Florida; made of gold, silver, brass, stone and wood.

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The Port Of St. Augustine During The British Regime, Wilbur H. Siebert Mar 2021

The Port Of St. Augustine During The British Regime, Wilbur H. Siebert

Florida Historical Quarterly

A little more than six miles of Anastasia island, eastward of St. Augustine, is shown on the old map by De Brahm, one-time surveyor-general for the Southern District of British America. The channel is depicted and, less than a mile east of the fortress or “castle,” the bar. The Look-out Tower stands two thirds of the island’s width at that point from its inner side, a little more than a fifth of a mile from its outer side, and half a mile from the shore directly north. De Brahm’s survey was made in 1765 and 1766. On a much earlier …

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Tiger Tail, Kenneth W. Porter Mar 2021

Tiger Tail, Kenneth W. Porter

Florida Historical Quarterly

The career of Thlocklo Tustenuggee (Fish Warrior), better known by his nickname of Tiger Tail, who was one of the most determinedly hostile of the Seminole chiefs in the war of 1835-42, may be of no great importance. It has, however, already received sufficient attention to justify, it would seem, the addition of new information. The standard account, found in Sprague, is that he died, perhaps of homesickness, shortly after his transportation from Florida. It has, however, been more recently asserted that Tiger Tail never left Florida, but, substituting one of his. warriors, who had been beaten into unrecognizability in …

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Writing Local History, Lillie B. Mcduffee Mar 2021

Writing Local History, Lillie B. Mcduffee

Florida Historical Quarterly

Probably in every one of Florida’s sixty-seven counties there is waiting for some aspiring writer of history a wealth of material which could be used effectively in building a county or local history. This is a field of endeavor which in Florida has largely been neglected, and one which should arouse the pride of Floridians over the State who may be history-minded.

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Pioneer Florida: An Interpretation Of Spanish Laws And Land Titles, T. Frederick Davis Mar 2021

Pioneer Florida: An Interpretation Of Spanish Laws And Land Titles, T. Frederick Davis

Florida Historical Quarterly

When Florida was acquired by the United States from Spain through the treaty of cession concluded and signed in 1819 and ratified in 1821, one of the foremost questions arising was that of the confirmation of land titles. For a decade there was a strange uncertainty with regard to property, titles and judicial decrees, which, according to a contemporary writer in the Florida Herald, were “scattered about as floating objects in the wide ocean of Law.” He goes on to say, “This confusion cannot be supposed to arise from any intention or design in the high contracting parties [the governments …

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The Florida Banditti, 1783, Joseph B. Lockey Mar 2021

The Florida Banditti, 1783, Joseph B. Lockey

Florida Historical Quarterly

East Florida was ill at ease on receiving, in the spring of 1783, news of the retrocession of the province to Spain. The necessity of abandoning homes in a land to which government and people alike were attached, together with the uncertainties, vexations, and difficulties of finding new homes elsewhere presented to all a dark picture of the future. In the midst of these apprehensions some of the settlers at least were troubled by the depredations of a group of lawless men whom Governor Patrick Tonyn described as banditti.

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Tallahassee And St. Marks In 1841, A Letter Of John S. Tappan, John S. Tappan Mar 2021

Tallahassee And St. Marks In 1841, A Letter Of John S. Tappan, John S. Tappan

Florida Historical Quarterly

No abstract provided.

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Pioneer Florida: Jackson’S Premature Proclamation, 1821, T. Frederick Davis Mar 2021

Pioneer Florida: Jackson’S Premature Proclamation, 1821, T. Frederick Davis

Florida Historical Quarterly

The treaty of “Amity, Settlement and Limits” by which Spain ceded the Floridas (East and West) to the United States, was concluded and signed on February 22, 1819, but ratifications were not exchanged until February 22, 1821 - both transactions coincidentally being on the anniversary of George Washington’s birth. On March 10, 1821, General Andrew Jackson was appointed to take over the Floridas from Spain, and assume their government pending their formal creation as a territory of the Union. The commission bestowed upon him the title: Governor of the Floridas, exercising all the powers and authorities heretofore exercised by the …

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The Last Spanish Census Of Pensacola, Duvon C. Corbitt Mar 2021

The Last Spanish Census Of Pensacola, Duvon C. Corbitt

Florida Historical Quarterly

Prior to 1812 the Spanish monarch did not see fit to grant Pensacola the right to organize as a municipality; consequently, the West Florida capital was governed up to that year by military commandants whose authority was untrammeled by elective officers. With the inauguration of the Constitution of 1812, however, it became necessary to allow the organization of municipal government there, since the charter in question provided such government for all towns and communities having one thousand or more free inhabitants, or whose special conditions necessitated local government. Therefore, Pensacola’s municipal government, consisting of an alcalde, or mayor, and a …

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Florida's Population In 1845, Dorothy Dodd Mar 2021

Florida's Population In 1845, Dorothy Dodd

Florida Historical Quarterly

The first census of the State of Florida was taken in the summer of 1845. The census takers were slow in making their returns, and data for only 17 of the 26 counties were submitted to the adjourned session of the General Assembly, which met in November. The census was actually taken, however, in every county except St. Lucia and Dade, a total of 66,381 inhabitants being reported.

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Florida In 1845, Dorothy Dodd Mar 2021

Florida In 1845, Dorothy Dodd

Florida Historical Quarterly

When the government of the State of Florida was organized in June 1845, the state contained a population of some 66,500. Although Florida has a total area of 58,560 square miles, 2 47 percent of the population was concentrated in the 7,333 square miles (only 12.5 percent of the state total) lying between the Apalachicola and Suwannee rivers, then known as Middle Florida. The remaining 53 percent was distributed fairly evenly between West and East Florida, 25 percent being in the former and 28 percent in the latter. But since West Florida -between the Perdido and Apalachicola rivershas an area …

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Tequesta: Journal Of The Historical Association Of Southern Florida, Florida Historical Society Mar 2021

Tequesta: Journal Of The Historical Association Of Southern Florida, Florida Historical Society

Florida Historical Quarterly

The fourth issue of Tequesta, “The Journal of the Historical Association of Southern Florida” appeared while the last number of our Quarterly was in press. This one was edited by Professor Leonard R. Muller, of the University of Miami, with an advisory board of Harold E. Briggs, David O. True, and H. Frank Williams.

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The Beginnings Of Printing In Florida, Douglas C. Mcmurtrie Mar 2021

The Beginnings Of Printing In Florida, Douglas C. Mcmurtrie

Florida Historical Quarterly

Printing came to Florida not as a result of natural expansion with a gradually increasing necessity for a press, nor for the purpose of Christianizing the Indians as was the case in some other areas; printing was introduced there as a result of war conditions outside the province. Florida had passed from Spanish to English hands in 1763 and had remained true to England throughout the Revolution, offering a haven for Tory refugees from the colonies to the north. In 1782 there was a great influx of loyalist Georgians, and later in the year, with the withdrawal of British troops …

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The Tallahassee Historical Society's "Apalachee", Florida Historical Society Mar 2021

The Tallahassee Historical Society's "Apalachee", Florida Historical Society

Florida Historical Quarterly

The Tallahassee Historical Society has long been one of the most active local historical associations in Florida. Program meetings are held during each winter at which carefully prepared papers are read, many of them having been written after extensive research. Several of these papers have been published in this Quarterly, and a much larger number were selected and published at intervals as The Annual of the Tallahassee Historical Society in 1934, 1935, 1937 and 1939. These are mimeographed volumes of sixty to one hundred twenty pages.

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The Challenges And Successes Of Teaching In A Pandemic - A Nursing Faculty Commentary, Katie Daigle Mar 2021

The Challenges And Successes Of Teaching In A Pandemic - A Nursing Faculty Commentary, Katie Daigle

Journal of Interprofessional Practice and Collaboration

The purpose of this paper is to discuss alternative teaching methods, specifically those used for nursing clinical instruction during the abrupt transition to the online environment during the COVID-19 pandemic.

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Human-Robot Collaboration For Effective Bridge Inspection In The Artificial Intelligence Era, Ruwen Qin Mar 2021

Human-Robot Collaboration For Effective Bridge Inspection In The Artificial Intelligence Era, Ruwen Qin

INSPIRE Archived Webinars

Advancements in sensor, Artificial Intelligence (AI), and robotic technologies have formed a foundation to enable a transformation from traditional engineering systems to complex adaptive systems. This paradigm shift will bring exciting changes to civil infrastructure systems and their builders, operators and managers. Funded by the INSPIRE University Transportation Center (UTC), Dr. Qin’s group investigated the holism of an AI-robot-inspector system for bridge inspection. Dr. Qin will discuss the need for close collaboration among the constituent components of the AI-robot-inspector system. In the workplace of bridge inspection using drones, the mobile robotic inspection platform rapidly collected big inspection video data that …

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Characterization Of Memory T-Lymphocyte Subsets In Dogs, Annie Beth Bauman Mar 2021

Characterization Of Memory T-Lymphocyte Subsets In Dogs, Annie Beth Bauman

LSU Master's Theses

A more complete understanding of canine T-cell immunity is necessary for improving diagnostic and therapeutic approaches to canine diseases, developing cell-based canine immunotherapeutics, and evaluating dogs as large mammal models for comparative immunology research. Canine immunological studies are limited by the lack of established phenotypic markers identifying diverse differentiation states in canine T-cells. Differential expression of CD45RA (indicating antigen experience) and CD62L (indicating lymph node homing capability), shows promise as a tool to delineate canine naïve (TN), central memory (TCM), effector memory (TEM), and terminal effector memory (TEMRA) T-cells. The aim of this study was to characterize canine memory T-cell …

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Using The Seventh Rib Length And Depth Measurements As A Method To Estimate Ancestry And Sex In Adults, Alexandria M. Amaki Mar 2021

Using The Seventh Rib Length And Depth Measurements As A Method To Estimate Ancestry And Sex In Adults, Alexandria M. Amaki

LSU Master's Theses

This study tested the correlation of dimensions of the left seventh rib (L7) to ancestry and sex in adult humans. The first hypothesis, based on Bergmann’s theory, is that Black (African-American) individuals will have smaller L7 dimensions than White individuals (Americans of primarily European descent). The second hypothesis is that males, due to sexual dimorphism, will have larger ribs than females. 299 individuals from the Hamann-Todd Skeletal Collection were used in the study, approximately evenly distributed among sex and ancestry groups. Five variables were examined, including three measurements (length, width, and width point), and two calculations (area and ratio). A …

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Anxiety And Depression's Incremental Effect On Executive Functioning Deficits In Children And Adolescents, Paige Picou Mar 2021

Anxiety And Depression's Incremental Effect On Executive Functioning Deficits In Children And Adolescents, Paige Picou

LSU Master's Theses

Children and adolescents experiencing anxiety and/or depression experience impairment in a myriad of domains and often engage in maladaptive strategies that then exacerbate or prolong their current symptomology. However, there is still a paucity of research examining anxiety and depression’s impact on executive functioning in children and adolescents, and existing research is muddled with problems in how researchers both define and choose to measure executive functioning. This study aims to clarify some of the conflicting research on anxiety and depression’s impact on executive functioning by using Barkley’s hybrid theory of executive functioning to determine whether anxiety and depressive symptomology add …

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The Concept Of Transparency In The Work Of The Courts And Its Role In The Administration Of Justice, Erkin Kuchkarbaevich Sabirov Mar 2021

The Concept Of Transparency In The Work Of The Courts And Its Role In The Administration Of Justice, Erkin Kuchkarbaevich Sabirov

ProAcademy

The article examines the concept of transparency in the activities of the courts and its role in the administration of justice. Information about the private lives of persons who cannot be disclosed and will be heard in closed court shall be specified in detail and shall include personal audio and video recordings, photographs and films, electronic, digital and other documentary means in addition to personal correspondence and other personal messages. When the case is heard in closed session of the court, it should be borne in mind that the participation of persons under the age of sixteen is not allowed …

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Preventing Insulin Storage And Administration Errors, Makena Reddick Mar 2021

Preventing Insulin Storage And Administration Errors, Makena Reddick

Scholars Week

■The research problem was discovered when nurses were observed storing and administering insulin improperly. The objectives of this project were to find the correct policies for these procedures, obtain research that backed these policies, and present this information to nurses to create a safer habit. In researching, it was found that reducing the physical distance between a person completing work and the materials required to do so increased compliance (Gibbs & McLernon, 2017). In a second study, the delivery of safe, effective and high-quality care for patients with diabetes in the community is dependent upon (district) nurses having appropriate knowledge …

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State V. Scott Mcdaniel White Appellant's Brief Dckt. 47976 Mar 2021

State V. Scott Mcdaniel White Appellant's Brief Dckt. 47976

Not Reported

No abstract provided.

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