Digital Commons Network^™

Combinatorial Effect Of Epirubicin And 5-Fluorouracil In The Treatment Of Temozolomide-Resistant Glioblastoma Cells, Mehrsa Bayat, Muhli̇s Akman, Türker Kiliç, Ti̇muçi̇n Avşar

Turkish Journal of Biology

Background: Glioblastoma (GBM) is a highly aggressive form of brain tumor characterized by rapid proliferation and invasiveness. It is associated with a poor prognosis due to acquired resistance to temozolomide (TMZ). In this study, we investigated whether a combination of epirubicin, 5-fluorouracil (5-FU), and TMZ could improve TMZ sensitivity in resistant GBM cells and help overcome resistance.Materials and methods: TMZ resistance was established in the U87MG cell line. The MTT assay was used to measure cell viability. Reactive oxygen species (ROS) and apoptosis were measured using flow cytometry. RNA-seq was used to evaluate genomic changes based on treatment with drugs …

Deep Learning Technology In Multimodal Remote Sensing Data Fusion To Analyze Crop Growth And Economic Forecast, Tianlong Jiang, Ziyang Liu, Li Sun

Turkish Journal of Agriculture and Forestry

This paper integrated multimodal remote sensing (RS) data with deep learning to develop a maize growth analysis and income prediction model based on CNN (Convolutional Neural Network)-Attention and Bi-LSTM (Bidirectional Long Short-Term Memory). Utilsing Landsat 8, Sentinel-2, and Sentinel-1 satellite data, the CNN-Attention network extracts vegetation features such as NDVI (Normalised Difference Vegetation Index), EVI (Enhanced Vegetation Index), and canopy density for corn growth stage identification and prediction. The study combined these features with meteorological, soil, and market data and fed them into a Bi-LSTM model for time series analysis to forecast corn income. The method achieved 98.3% accuracy in …

Long-Term Tillage And Straw Returning Practices Enhance Soil Humus Composition, Carbon Sequestration, And Ecological–Economic Benefits, Kai Wang

Turkish Journal of Agriculture and Forestry

While straw return is widely promoted, its specific effects on soil humus composition, structure, and ecological functions are not fully understood. This study investigates the long-term impacts of different straw types and farming practices on humus composition, carbon sequestration, and ecological–economic benefits. In Hunan Province’s paddy fields, six soils with 5–30-year farming histories were selected. Treatments included a blank control, corn straw return, and rice straw return, each replicated three times. Humus structure was analyzed via infrared spectroscopy, component contents were determined by alkali extraction, and a carbon footprint model assessed emissions. Ecological economic analysis integrated soil carbon pool dynamics, …

Piloting A Scalable Workflow To Identify Drivers Of Mammalian Aging Using C. Elegans, Ariella Lucia Coler-Reilly Colasanti

Arts & Sciences Graduate Student Theses and Dissertations

The aging population in developed countries has prompted experts to warn of the impending “silver tsunami” of older adults poised to overload already strained healthcare systems. Advanced age is the primary risk factor for most chronic diseases, and the vast majority of the elderly population is diagnosed with at least one such condition, if not several. The field of geroscience has emerged to study the processes responsible for age-related decline and devise methods to reduce this burden. A major branch of geroscience is the genetics of aging, including examining gene expression changes over time as well as exploring how genetic …

Biomechanical Effects Of Bilateral Torsion And Skeletal Fusion: A Case Study, Linnéa Forbes

Honors Projects

As part of both a personal endeavor and an academic project, I have investigated the aetiology and treatment of seemingly idiopathic and debilitating leg pain in a patient over the past 10 years. Via collaboration with medical professionals at Cincinnati Children’s Hospital, Cincinnati Premier Physical Therapy, and Cincinnati Women’s TriHealth, I have identified sources of pain at the anatomical level. The combination of internal femoral torsion, external tibial torsion, pes planus, and bony fusions appear to be major perpetuators of the pain. An effective treatment continues to be evasive. To date, I have attempted to find answers through genetic approaches, …

Quantifying Sleep Wake Rhythms In The Hospital Environment With Digital Technologies, Carsten Skarke, Nadim El Jamal, Michael V. Genuardi, Thomas G. Brooks, Antonijo Mrčela, Nicholas F. Lahens, Makayla Cordoza, Sean Sarles, Amarachi Mbadugha, Dineth R. Karunamuni, Shikhar Gupta, Charles J. Bae, Amita Sehgal, Thomas P. Cappola, Jacob T. Gutsche, Pavan Atluri, Nimesh D. Desai, Michael A. Acker, Gregory R. Grant, Richard J. Schwab, Ilene M. Rosen, Garret A. Fitzgerald

Division of Cardiology Faculty Papers

Postoperative clinical care is prone to circadian desynchronization that may influence health outcomes. In an exploratory, feasibility-oriented and signal-exploration effort, we collected 1.8 million data points using 11 remote sensors during preoperative, in-hospital and post-discharge settings in 13 elective cardiac surgery patients (5.2% enrolled from 252 screened). We found that room traffic continued during nighttime with ≥1 visit/h. Sound levels exceeded the recommended 45 dBA threshold (51.9 ± 3.3 vs. 48.3 ± 4.2 dBA during nighttime). Brightness dropped at night (89.9 ± 87.7 to 3.7 ± 9.8 lux), but bright light exposures occurred. Ambient room temperature lacked sleep-inducing diurnal variability. …

Memory Representations In Cortico-Hippocampal Systems, Angelique Ibanez Delarazan

Arts & Sciences Graduate Student Theses and Dissertations

Episodic memory often captures both the content of past events (e.g., people, places, and situations involved) and the specificity with which those events are remembered, ranging from summary-level to detailed recollection. Content-based theories, including the PMAT Framework, propose that cortical networks are organized around the types of information memories contain. In particular, the Anterior Temporal Network (ATN) supports entity representations, including characters, and the Posterior Medial Network (PMN) support contextual information, such as locations. Specificity-based theories, including the Trace Transformation Theory, propose that the level of recall specificity maps onto functional gradients within the hippocampus, with posterior regions (pHPC) supporting …

Modulating Microtubule Stability Via Α-Tubulin Acetylation Partially Restores Golgi Fragmentation In Spinal Muscular Atrophy, Peli̇n Zobaroğlu Özer, Memet Gözüböyük, Özge Çeti̇n, Niko Hensel, Güzi̇n Emecen, Adam Malik, Melissa Bowerman, Peter Claus, Hayat Erdem Yurter, Gamze Bora Akoğlu

Turkish Journal of Biology

Background/aim: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of survival of motor neuron (SMN) protein. SMN deficiency leads to perturbations of the cytoskeleton, including microtubules, which are mainly involved in motilityrelated cellular processes. However, the molecular mechanisms of microtubule dysregulation in SMA remain elusive. Alpha (α)-tubulin is a structural component of microtubules, and its posttranslational modifications affect microtubule dynamics. Here, we aimed to investigate α-tubulin acetylation and related molecular mechanisms in SMA. Materials and methods: Two different SMA mouse models, the Drosophila melanogaster model and patient-derived fibroblasts, were used in the study. Western blot and …

Laboratory Charter School V. M. S.

2026 Decisions

USDC for the Eastern District of Pennsylvania

Turbulence, Sophia Caneira

The Alembic

No abstract provided.

For The Sins Of The Father, Mary Kate Seiberlich

The Alembic

No abstract provided.

Integration Of Bayesian Networks And Neural Networks For High-Dimensional Data Analysis, Cooper Schmer

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

High-dimensional biomedical datasets, such as omics data, present significant challenges for predictive modeling due to noise, redundancy, and computational complexity. This thesis proposes a hybrid framework that integrates Bayesian Networks (BNs) and Artificial Neural Networks (NNs) to improve classification performance of such data sets while reducing input dimensionality. Central to this work is a novel feature selection method based on d-separation, a structural property of Bayesian networks that encodes conditional independence relationships.

The proposed approach introduces a count-based d-separation metric to quantify the relevance of variables to a target outcome, along with a thresholding scheme to balance feature selection robustness …

Development And Validation Of Kinetics And Musculoskeletal Modeling For The Milwaukee Foot Model, Maxine L. Olson

Dissertations (1934 -)

Many children are afflicted by foot and ankle pathologies which affect the ankle, midfoot, and metatarsophalangeal joints. However, a clinically feasible foot model capable of assessing multi-segment kinetics throughout the gait cycle does not exist. Similarly, a musculoskeletal foot model utilizing multiple ground reaction forces (GRF) and Milwaukee Foot Model (MFM) kinematics has not been created. The purpose of this study was to develop a clinically feasible method of modeling multi-segment foot properties without increased clinician and/or patient burden or expense. To this end, a force distribution algorithm (FDA) was created, allowing for calculation of multi-segment foot kinetics, musculoskeletal modeling, …

Protective Effect Of Pinocembrin On Zearalenone-Induced Hepatotoxicity Via Pi3k/Akt And Nrf2 Signaling In Albino Mice, Sujatha Tejavat

Turkish Journal of Biology

Background/aim: Zearalenone (ZEA) is a Fusarium-derived mycotoxin that frequently contaminates food and feed and induces hepatotoxicity in humans and animals through oxidative stress and inflammation. Pinocembrin (PCM), a naturally occurring flavonoid, has potent antioxidant and antiinflammatory properties. This study investigated the hepatoprotective effects of PCM against ZEAinduced liver injury in albino mice, with a focus on the nuclear factor erythroid 2–related factor 2 (NRF2) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathways. Materials and methods: Twenty-four albino male mice were allocated into four groups: (1) control (vehicle 0.05% dimethyl sulfoxide), (2) ZEA-treated (40 mg/kg body weight), (3) PCM-treated (50 mg/kg …

A Proposed Methodology For Online Asynchronous Therapeutic Dreamwork, Gregory Sparrow, Ryan Hurd, Yih-Jiun Shen, Kim Phetteplace

Counseling Faculty Publications

The COVID-19 pandemic accelerated the acceptance of online “telemental” health as an alternative to sitebased service delivery. Concurrently, therapists have adopted various asynchronous virtual mental health resources, such as bulletin boards/forums, delayed chat, and email, to supplement traditional practice. Asynchronous dream sharing, pioneered in the early 1980s, has since supported online conferences and ongoing dreamwork communities. However, the potential of asynchronous therapeutic dreamwork (ATD) still needs to be explored. This article reviews the evolution of asynchronous online dream sharing and proposes that combining it with “co-creative” dreamwork—particularly the FiveStar Method—may generate distinctive contributions while providing greater safeguards than content-focused interpretive …

Analysis Of Agricultural Remote Sensing Data Driven By Artificial Intelligence On Crop Growth Patterns And Economic Benefits Of Grain, Yang Wang

Turkish Journal of Agriculture and Forestry

To address the shortcomings of conventional agricultural statistical and monitoring methods on a regional scale, this paper proposes the use of artificial intelligence-driven remote sensing data for analysing crop growth patterns and the economic benefits of grain. Winter wheat data from three stations in a single province from 2011 to 2020 was used, with the leaf area index (LAI) used as the key crop growth indicator value. The simulated annealing algorithm was used to assimilate the LAI and remote sensing leaf area index (MODIS-LAI), simulated by the World Food Study (WOFOST) simulation model, to carry out simulation analysis of winter …

Space Degradable Pyrotechnic Fastener, Jonathan Baker

Honors Theses

Space debris has become a critical threat to orbital operations, with over 30,000 tracked objects currently circling Earth. Traditional separation charges used in satellite launches contribute significantly to this problem by generating unpredictable shrapnel that can remain in orbit for decades or centuries. This project proposes the design and development of a spacedegradable explosive bolt that exploits the harsh space environment to accelerate material breakdown after use.

The design utilizes advanced polymer materials selected for their susceptibility to degradation from UV radiation — an environmental factor abundant in Low Earth Orbit (LEO). Our prototype will be engineered to meet industry-standard …

Development Of A Grease Resistant Barrier For Food Industry Applications, Mira Marino

Honors Theses

The objective of this project is to develop a grease-resistant barrier coating for paper-based food packaging and to evaluate the economic feasibility of implementing this coating system at an industrial scale. As demand increases, this project focuses on identifying an optimal pigment and binder combination that enhances barrier performance while maintaining cost-effectiveness. The primary goal was to maximize grease and moisture resistance of coated paper while ensuring the process is economically viable and compatible with existing paper mill operations.

The final plant design consists of one continuous stirred tank reactor (CSTR) and three centrifugal pumps integrated into an existing paper …

Model Unification: A Systematic Approach For The Cluster Expansion, Kolten Barfuss

Theses and Dissertations

A systematic approach for model unification of cluster expansion models is developed and demonstrated. The method builds on previous work with the Manifold Boundary Approximation Method (MBAM) to identify supremal models. The work is motivated by the exercise of unifying cluster expansion models – characterized by Π matrices – for two binary alloys that share one atomic species to form a model for the ternary alloy. The result is the Supremal Π Algorithm, a systematic unification algorithm that relies on an MBAM-informed understanding of models and on the singular value decomposition. The algorithm yields ΠΛ, a Π matrix for the …

Deep Learning And Experimental Validation Of Brca1-Associated Protein-1 Missense Variant Pathogenicity In Uveal Melanoma, Nikhil Davé, David J. Taylor Gonzalez, Mak B. Djulbegovic, Linda A. Cernichiaro-Espinosa, Benjamin A. King, Carol L. Shields, Matthew W. Wilson

Wills Eye Hospital Papers

OBJECTIVE: To benchmark the pathogenicity predictions of AlphaMissense, a deep learning model, against high-throughput functional scores from saturation genome editing (SGE) for all experimentally tested BRCA1-associated protein-1 (BAP1) missense variants in uveal melanoma (UM).

DESIGN: Cross-sectional analytical study comparing computational predictions with experimentally derived functional classifications and clinical annotations.

SUBJECTS PARTICIPANTS AND/OR CONTROLS:  ClusteredAll 4619 BAP1 single amino acid substitutions profiled in a published Regularly Interspaced Short Palindromic Repeats-Cas9 SGE viability assay. No separate control cohort was required. Clinical Variant Database (ClinVar)-annotated variants within this set served as an independent reference.

METHODS: Saturation genome editing log₂-fitness …

Staff Education To Integrate Evidence-Based Practice Of Music Therapy As An Adjunct To Cognitive Behavioral Therapy For Anxiety And The Use Of Anxiety Screening Tool In An Outpatient Clinic, Virginia Bahena

Walden Dissertations and Doctoral Studies

Evidence-based practice (EBP) is essential for improving quality, safety, and outcomes in healthcare; however, gaps in staff knowledge and readiness continue to limit consistent implementation in outpatient settings. This Doctor of Nursing Practice project was a practice-focused quality improvement initiative designed to evaluate the impact of a targeted staff education intervention on EBP knowledge and readiness. The practice-focused question guiding the project was: Does a targeted staff education intervention improve knowledge and readiness to integrate brief music therapy as an adjunct to cognitive behavioral therapy (CBT) and appropriately utilize the Generalized Anxiety Disorder-7 (GAD-7) screening tool in an outpatient setting? …

Lived Experiences Of Eye Movement Desensitization And Reprocessing (Emdr) Certified, Staci Ekblad

Walden Dissertations and Doctoral Studies

This phenomenological study explored counselors’ lived experiences of utilizing Eye Movement Desensitization and Reprocessing (EMDR) with children ages 8 to 12 years of age. Guided by a Husserlian approach, the research examined how clinicians make meaning of adapting EMDR—traditionally conceptualized as a structured, eight-phase protocol—for developmental and relational responsiveness within child psychotherapy. Through phenomenological reduction and epoché, counselors described a shift in consciousness from viewing EMDR as a rigid procedure to experiencing it as a flexible, relationally attuned process grounded in the child’s lived world. Counselors described the phenomenon of implementing EMDR with children with playful adaptations and co-regulation. The …

Perceptions And Experiences Of Federal Employees Following The Dissolution Of Deia Initiatives, Angela Silva

Walden Dissertations and Doctoral Studies

The federal government faces the ongoing challenge of sustaining a workforce that represents the diversity of the American public while navigating through policy changes that eliminated diversity, equity, inclusion, and accessibility initiatives. The federal government is public serving and is one of the largest employers in the United States. The purpose of this generic qualitative study was to explore the perceptions and experiences of government employees navigating the termination of all diversity and inclusion programs through the lens of the antecedents and outcomes of inclusions model, which showed that inclusive leadership, climate and practices contribute to positive employee and organizational …

Psychosocial Characteristics Of North American Male Cannibals, Sheila A. Murphy

Walden Dissertations and Doctoral Studies

Criminal cannibalism is a rare form of violent offending that remains understudied despite public attention. This gap limits understanding of the psychosocial characteristics and life experiences of individuals who engage in cannibalistic behavior. The purpose of this qualitative study was to explore psychosocial characteristics within the life experiences of North American males who engaged in cannibalistic behavior and identify common themes. Grounded in social control theory and self-control theory, the study examined how weakened social bonds and diminished self-regulation may relate to extreme deviance. The guiding research question focused on identifying common psychosocial characteristics within this population. A descriptive phenomenological …

Psychometric Properties Of A Newly Developed Self-Report Scale To Determine The Relationship Between Retained Primary Reflexes And Behavioral Signs And Symptoms In An Adult Population, Joan Marie Macmillan

Walden Dissertations and Doctoral Studies

Many adults suffer from mental health issues, often caused by retained primary reflexes. There are current gaps in the literature surrounding primary reflex assessment methods. The purpose of this quantitative psychometric study was to evaluate the psychometric properties of a new behavioral self-assessment scale used to identify retained primary reflexes from behavioral indicators, while also determining if statistically significant relationships exist among study variables. The theoretical foundation for this cross-sectional study was based on the neurodevelopmental and neurobehavioral work of Melillo, while conceptually benefiting from several neuroplasticity related frameworks, such as those developed by Ayres, Bach-y-Rita, and Masgutova. The self-report …

Early Childhood Educators’ Experiences Teaching Literacy Acquisition Skills, Dena Renee Crews

Walden Dissertations and Doctoral Studies

The problem investigated through this study was that early childhood educators struggle to help students with literacy acquisition skills in a Title 1 elementary school. The purpose of this qualitative study was to investigate early childhood educators’ experiences with the challenges of teaching literacy acquisition skills and their suggestions for improving resources and training for teaching literacy acquisition skills. The study was grounded in Clay’s emergent literacy theory and Bronfenbrenner’s ecological systems theory. For this basic qualitative design, semistructured interviews with 14 participants were conducted with the following themes emerging: Early childhood educators were challenged due to (a) students’ background …

Spartan Daily, April 21, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 35

Tracey-Douglas V. Douglas

All Decisions

In a holdover proceeding, the tenant's motion to dismiss was granted due to the landlord's failure to properly serve the predicate 60-day notice. The purported substitute service was defective as it lacked proof of required mailings. Additionally, the landlord failed to comply with the Good Cause Eviction Law (GCEL) pleading requirements. Although claiming a "small landlord" exemption, the petition did not provide the statutorily mandated disclosures and contained contradictory allegations regarding the grounds for eviction. The court dismissed the petition against all respondents.

Defenders Assemble: A Blueprint For Building Antiracist Public Defender Offices, Ieshaah Murphy

Seton Hall Law Review

No abstract provided.

Look To The Children: How New Jersey's Anti-Bullying Bill Of Rights Can Provide A Framework For Workplace Bullying, Bridget Knodel

Seton Hall Law Review

No abstract provided.