Digital Commons Network^™

Impaired Health-Related Quality Of Life In Idiopathic Inflammatory Myopathies: A Cross-Sectional Analysis From The Covad-2 E-Survey, Akira Yoshida, Yuan Li, Vahed Maroufy, Masataka Kuwana, Syahrul Sazliyana Shaharir, Ashima Makol, Parikshit Sen, James B Lilleker, Vishwesh Agarwal, Esha Kadam, Phonpen Akawatcharangura Goo, Jessica Day, Marcin Milchert, Yi-Ming Chen, Dzifa Dey, Tsvetelina Velikova, Sreoshy Saha, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Elena Nikiphorou, Ai Lyn Tan, Arvind Nune, Lorenzo Cavagna, Carlos Enrique Toro Gutiérrez, Carlo Vinicio Caballero-Uribe, Miguel A Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Lina El Kibbi, Johannes Knitza, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta

Faculty, Staff and Student Publications

OBJECTIVES: to investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database.

METHODS: Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed. Primary outcomes were PROMIS Global Physical Health (GPH) and Global Mental Health (GMH) scores. Factors affecting GPH and GMH scores in IIMs were identified using multivariable regression analysis.

RESULTS: We analysed responses from 1582 …

A Service-Oriented Approach To Clinical Trial Recruitment For Dementia And Brain Health: Methods And Case Examples Of Myalliance For Brain Health, Eric D Vidoni, Emma Swinford, Kelli Barton, Jaime Perales-Puchalt, C Michelle Niedens, Tina Lewandowski, Tiffany Schwasinger-Schmidt, Jill Peltzer, Joellen Wurth, Jannette Berkley-Patton, Ryan A Townley, W Todd Moore, Ashley R Shaw, Mickeal N Key, Erica Andrade, Melissa Robinson, Susan Sprague, Aiden Bondurant, Debra Brook, Jennifer Freund, Jeffrey M Burns

Faculty, Staff and Student Publications

Introduction: Recruitment of sufficient and diverse participants into clinical research for Alzheimer's disease and related dementias remains a formidable challenge. The primary goal of this manuscript is to provide an overview of an approach to diversifying research recruitment and to provide case examples of several methods for achieving greater diversity in clinical research enrollment.

Methods: The University of Kansas Alzheimer's Disease Research Center (KU ADRC) developed MyAlliance for Brain Health (MyAlliance), a service-oriented recruitment model. MyAlliance comprises a Primary Care Provider Network, a Patient and Family Network, and a Community Organization Network, each delivering tailored value to relevant parties while …

Employee Handbook, Saint Mary's College Of California

Employee & Staff Handbook

No abstract provided.

Causal Association Between Gut Microbiomes And Different Types Of Aneurysms: A Mendelian Randomization Study, Youjia Qiu, Yucheng Hou, Xingzhou Wei, Menghan Wang, Ziqian Yin, Minjia Xie, Aojie Duan, Chao Ma, Ke Si, Zhong Wang

Faculty, Staff and Student Publications

BACKGROUND: Previous studies suggests that gut microbiomes are associated with the formation and progression of aneurysms. However, the causal association between them remains unclear.

METHODS: A two-sample Mendelian randomization was conducted to investigate whether gut microbiomes have a causal effect on the risk of intracerebral aneurysm (IA), thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA), and aortic aneurysm (AA). Single nucleotide polymorphisms (SNPs) smaller than the locus-wide significance level (1 × 10

RESULTS: The phylum

CONCLUSION: Our MR analysis confirmed the causal association of specific gut microbiomes with AAA, and these microbiomes were considered as protective factors. Our result …

Generalized Conditional Feedback System With Model Uncertainty, Chengbo Dai, Zhiqiang Gao, Yangquan Chen, Donghai Li

Electrical and Computer Engineering Faculty Publications

Model uncertainty creates a largely open challenge for industrial process control, which causes a trade-off between robustness and performance optimality. In such a case, we propose a generalized conditional feedback (GCF) system to largely eliminate conflicts between robustness and performance optimality. This approach leverages a nominal model to design an optimal control in the virtual domain and defines an ancillary feedback controller to drive the physical process to track the trajectory of the virtual domain. The effectiveness of the proposed GCF scheme is demonstrated in a simulation for six typical industrial processes and three model-based control methods, and in a …

2023-2024 Louisiana Adult Justice, Institute For Public Health And Justice, Data Collecting And Reporting

Policy & Position Papers

No abstract provided.

2023-2024 Louisiana Juvenile Justice, Institute For Public Health And Justice, Data Collecting And Reporting

Policy & Position Papers

No abstract provided.

Social Determinants Of Health Predict Readmission Following Covid-19 Hospitalization: A Health Information Exchange-Based Retrospective Cohort Study, Micaela N Sandoval, Jennifer L Mikhail, Melyssa K Fink, Guillermo A Tortolero, Tru Cao, Ryan Ramphul, Junaid Husain, Eric Boerwinkle

Faculty, Staff and Student Publications

INTRODUCTION: Since February 2020, over 104 million people in the United States have been diagnosed with SARS-CoV-2 infection, or COVID-19, with over 8.5 million reported in the state of Texas. This study analyzed social determinants of health as predictors for readmission among COVID-19 patients in Southeast Texas, United States.

METHODS: A retrospective cohort study was conducted investigating demographic and clinical risk factors for 30, 60, and 90-day readmission outcomes among adult patients with a COVID-19-associated inpatient hospitalization encounter within a regional health information exchange between February 1, 2020, to December 1, 2022.

RESULTS AND DISCUSSION: In this cohort of 91,007 …

Lysophospholipids Are Associated With Outcomes In Hospitalized Patients With Mild Traumatic Brain Injury, Aaron M Gusdon, Jude Pj Savarraj, John B Redell, Atzhiry Paz, Sarah Hinds, Angela Burkett, Glenda Torres, Xuefang Ren, Neeraj Badjatia, Georgene W Hergenroeder, Anthony N Moore, H Alex Choi, Pramod K Dash

Faculty, Staff and Student Publications

Mild traumatic brain injury (mTBI) accounts for 70-90% of all TBI cases. Lipid metabolites have important roles in plasma membrane biogenesis, function, and cell signaling. As TBI can compromise plasma membrane integrity and alter brain cell function, we sought to identify circulating phospholipid alterations after mTBI, and determine if these changes were associated with clinical outcomes. Patients with mTBI (Glasgow Coma Score [GCS] ≥13 and loss of consciousness <30 >min) were recruited. A total of 84 mTBI subjects were enrolled after admission to a level I trauma center, with the majority having evidence of traumatic intracranial hemorrhage on brain computed tomography …

Increased Resolvin E1 Production By Peripheral Blood Mononuclear Cells In Periodontitis Patients: Pilot Study, Lina J Suárez, Wilmer González-Duarte, Rodrigo Torrez-Velasco, Viviana Salinas, Nelly S Roa-Molina, Sindy M Muñoz, Luz-Stella Rodríguez, Roger M Arce, Jamil A Shibli, Adriana Rodríguez-Ciodaro

Faculty, Staff and Student Publications

This study quantified the production of the pro-resolving agent Resolvin E1 by peripheral blood mononuclear cells (PBMC) from 20 systemically healthy volunteers with and without periodontitis after stimulation with lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg). Ten periodontitis patients and 10 healthy volunteers (30-50 years old), matched by age and sex, were recruited. Peripheral blood mononuclear cells were isolated and stimulated in culture plates for 24 hours with Pg LPS. Resolvin E1 levels were measured in the supernatants by enzyme-linked immunosorbent assay. Significantly higher production of Resolvin E1 was observed in both groups when stimulated with LPS compared to baseline levels …

A Virtual Culinary Medicine Intervention For Ethnically Diverse Individuals With Type 2 Diabetes: Development Of The Nourishing The Community Through Culinary Medicine, Lorena Macias-Navarro, John Wesley Mcwhorter, Diana C Guevara, Sarah S Bentley, Shreela V Sharma, Jennifer H Torres, David Ai, Natalia I Heredia

Faculty, Staff and Student Publications

Virtual culinary medicine education interventions have the potential to improve dietary behaviors, nutrition knowledge, cooking skills, and health outcomes for ethnically diverse individuals with type 2 diabetes. The purpose of this study is to describe the adaptation of the Nourishing the Community through Culinary Medicine (NCCM) program for virtual delivery, and the protocol for pilot testing this intervention. The intervention includes five 90-min virtual NCCM sessions streamed live from a Teaching Kitchen. Feasibility outcomes are recruitment, retention, acceptability, and satisfaction. Short-term effectiveness outcomes are measured through self-administered questionnaires, including perceived health, average daily servings of fruits and vegetables, frequency of …

Circulating Sphingolipids In Relation To Cognitive Decline And Incident Dementia: The Cardiovascular Health Study, Kristine F Moseholm, Héléne T Cronjé, Manja Koch, Annette L Fitzpatrick, Oscar L Lopez, Marcia C De Oliveira Otto, W T Longstreth, Andrew N Hoofnagle, Kenneth J Mukamal, Rozenn N Lemaitre, Majken K Jensen

Faculty, Staff and Student Publications

INTRODUCTION: Whether circulating levels of sphingolipids are prospectively associated with cognitive decline and dementia risk is uncertain.

METHODS: We measured 14 sphingolipid species in plasma samples from 4488 participants (mean age 76.2 years; 40% male; and 25% apolipoprotein E (

RESULTS: Higher plasma levels of sphingomyelin-d18:1/16:0 (SM-16) were associated with a faster cognitive decline measured with 3MSE, in contrast, higher levels of sphingomyelin-d18:1/22:0 (SM-22) were associated with slower decline in cognition measured with DSST. In Cox regression, higher levels of SM-16 (hazard ration [HR] = 1.24 [95% confidence interval [CI]: 1.08-1.44]) and ceramide-d18:1/16:0 (Cer-16) (HR = 1.26 [95% CI: 1.10-1.45]) …

Trio Rvemvs: A Bayesian Framework For Rare Variant Association Analysis With Expectation-Maximization Variable Selection Using Family Trio Data, Duo Yu, Matthew Koslovsky, Margaret C Steiner, Kusha Mohammadi, Chenguang Zhang, Michael D Swartz

Faculty, Staff and Student Publications

It is commonly reported that rare variants may be more functionally related to complex diseases than common variants. However, individual rare variant association tests remain challenging due to low minor allele frequency in the available samples. This paper proposes an expectation maximization variable selection (EMVS) method to simultaneously detect common and rare variants at the individual variant level using family trio data. TRIO_RVEMVS was assessed in both large (1500 families) and small (350 families) datasets based on simulation. The performance of TRIO_RVEMVS was compared with gene-level kernel and burden association tests that use pedigree data (PedGene) and rare-variant extensions of …

Variant Of The Lactase Lct Gene Explains Association Between Milk Intake And Incident Type 2 Diabetes, Kai Luo, Guo-Chong Chen, Yanbo Zhang, Jee-Young Moon, Jiaqian Xing, Brandilyn A Peters, Mykhaylo Usyk, Zheng Wang, Gang Hu, Jun Li, Elizabeth Selvin, Casey M Rebholz, Tao Wang, Carmen R Isasi, Bing Yu, Rob Knight, Eric Boerwinkle, Robert D Burk, Robert C Kaplan, Qibin Qi

Faculty, Staff and Student Publications

Cow's milk is frequently included in the human diet, but the relationship between milk intake and type 2 diabetes (T2D) remains controversial. Here, using data from the Hispanic Community Health Study/Study of Latinos, we show that in both sexes, higher milk intake is associated with lower risk of T2D in lactase non-persistent (LNP) individuals (determined by a variant of the lactase LCT gene, single nucleotide polymorphism rs4988235 ) but not in lactase persistent individuals. We validate this finding in the UK Biobank. Further analyses reveal that among LNP individuals, higher milk intake is associated with alterations in gut microbiota (for …

The Relationship Of Neighborhood Disadvantage, Biological Aging, And Psychosocial Risk And Resilience Factors In Heart Failure Incidence Among Black Persons: A Moderated Mediation Analysis, Ganga S Bey, James R Pike, Anthony S Zannas, Qian Xiao, Bing Yu, Amil M Shah, Priya Palta

Faculty, Staff and Student Publications

Objectives: Deprived living environments contribute to greater heart failure (HF) risk among non-Hispanic Black persons, who disproportionately occupy disadvantaged neighborhoods. The mechanisms for these effects are not fully explicated, partially attributable to an insufficient understanding of the individual factors that contribute additional risk or resilience to the impact of neighborhood disadvantage on health. The objective of this study was, therefore, to clarify the complex pathways over which such exposures act to facilitate more targeted, effective interventions. Given the evidence for a mediating role of biological age and a moderating role of individual psychosocial characteristics in the neighborhood disadvantage-HF link, we …

Self-Perception Of Mental Health, Covid-19 And Associated Sociodemographic-Contextual Factors In Latin America, Pablo Roa, Guillermo Rosas, Gloria Isabel Niño-Cruz, Sergio Mauricio Moreno-López, Juliana Mejía-Grueso, Haney Aguirre-Loaiza, Javiera Alarcón-Aguilar, Rodrigo Reis, Adriano Akira Ferreira Hino, Fernando López, Deborah Salvo, Andrea Ramírez-Varela

Faculty, Staff and Student Publications

This study aimed to estimate the prevalence of alterations in self-perceived mental health during the COVID-19 pandemic and their associated factors in four Latin American countries. This is a cross-sectional study based on data collected from adults in 2021 through the Collaborative Response COVID-19 Survey by the MacDonnell Academy at Washington University in St. Louis (United States). The sample was composed of 8,125 individuals from Brazil, Colombia, Mexico, and Chile. A generalized linear model for a binary outcome variable with a logistic link and fixed country effects was used. There were 2,336 (28.75%) individuals who considered having suffered alterations in …

Prozone Masks Elevated Sars-Cov-2 Antibody Level Measurements, Micaela N Sandoval, Samuel P Mcclellan, Stephen J Pont, Jessica A Ross, Michael D Swartz, Mark A Silberman, Eric Boerwinkle

Faculty, Staff and Student Publications

We report a prozone effect in measurement of SARS-CoV-2 spike protein antibody levels from an antibody surveillance program. Briefly, the prozone effect occurs in immunoassays when excessively high antibody concentration disrupts the immune complex formation, resulting in a spuriously low reported result. Following participant inquiries, we observed anomalously low measurement of SARS-CoV-2 spike protein antibody levels using the Roche Elecsys® Anti-SARS-CoV-2 S immunoassay from participants in the Texas Coronavirus Antibody Research survey (Texas CARES), an ongoing prospective, longitudinal antibody surveillance program. In July, 2022, samples were collected from ten participants with anomalously low results for serial dilution studies, and a …

Leadership In Social Service Non-Profit Organizations: An Interpreative Phenomenlogical Analysis Of Executive Leadership High Attrition Levels And Proposals For Change, Stephanie Fredericka Wanza

Theses and Dissertations

The purpose of this study is to address how leaders who are employed at non-profit organizations can utilize change management frameworks, leadership style, strategic planning and organizational best practices to reduce attrition levels at their organizations. The focus of this study is three-fold: a) to understand why high attrition takes place at non-profits; identify what change model/s, types of leadership styles and best practices can be effective in reducing leader attrition, b) explore the development of a leadership framework by understanding how to manage change at nonprofits through the Carnall (1986), Shields (1999) and Cummings and Worley (2009) change management …

How Political Elite Leverage Twitter To Polarize America, Woodson Morris Hobbs V

Theses and Dissertations

While social media has changed how humans use the internet, Twitter has drastically reformed how individuals worldwide receive their news. As news outlets fail to keep up with the rapid dissemination of information online, Twitter has become a sounding board for the political elite who leverage the platform's immediacy and virality. This study, using Quantitative Ethnography's Epistemic Network Analysis, seeks to determine if the political elite, specifically members of Congress, are leveraging Twitter to spread polarizing information to strengthen their base. In this study, extensive coding of select members of the 118th Congress was completed and compared to Voteview.com's DW-Nominate …

A Systematic Review Of Risk And Protective Factors For Mental Health Among Latinx College Students, Melissa Gavilanes

Theses and Dissertations

A quantitative studies systematic review with narrative synthesis was conducted to explore the risk and protective factors among Latinx college students’ mental health. This systematic review also aimed to identify the relevant demographic variability to the mental health of Latinx college students, and the relationship between mental health and academic performance within this population. Data was collected from four electronic databases and included peer-reviewed articles published between 2000 and 2022, conducted within the United States, participants over the age of 17, and samples comprised of or including Latinx college students. Studies utilizing quantitative designs, and quantitative portions of mixed method …

Psychological Safety During The Covid-19 Pandemic Restrictions-A U.S. Healthcare Context, Mary Jean Brown

Theses and Dissertations

The pandemic forced many employees to transition to remote work, leading to concerns about the economic impact and inequities between remote and on-site workers. The shift to remote work has raised psychological safety issues, work-life balance, and employee engagement. The virtual workspace created during the pandemic has highlighted communication challenges, interpersonal dynamics, and maintaining boundaries between work and personal life. Through a quantitative approach, this study explored changes in perceived psychological safety, its relation to the psychosocial impact of COVID-19, and demographic factors, offering the opportunity to gain insights into this unprecedented experience during a global pandemic. Findings showed that …

Beyond The Classroom: Unraveling The Impact Of Student Engagement On Graduation Rates In New York City, Kimberly Mccall

Theses and Dissertations

This study critically examined the impact of student engagement on high school graduation rates amidst the educational disruptions ushered in by the COVID-19 pandemic, with a concentrated focus on the United States. It evaluated the essential engagement factors--rigorous instruction, collaborative teaching, supportive environments, and trust--and their role in addressing disparities in graduation outcomes (New York City Panorama, 2022; Wang & Degol, 2014). Anchored in the theoretical frameworks of Bronfenbrenner’s ecological systems theory (Bronfenbrenner, 1979), social-emotional learning theory (Durlak et al., 2011; Williamson et al., 2015), and Vygotsky’s sociocultural theory (Vygotsky, 1987), this research utilized a comprehensive quantitative analysis of data …

Addressing Inappropriate Polypharmacy: Investigating Perceived Facilitators And Barriers To U.S. Pharmacists' Ability To Recommend Deprescribing, Susanne Steiner

Theses and Dissertations

While the concurrent use of multiple prescriptions (polypharmacy) is common for those with chronic conditions, professional ownership is lacking when it comes to tapering or discontinuing potentially inappropriate medications. Our growing elderly population is especially vulnerable to negative risks associated with polypharmacy. Pharmacists are highly educated and skilled healthcare professionals working as critical touchpoints with patients; yet they are not empowered to deprescribe potentially inappropriate medications directly. This qualitative research study examined the perceived barriers and facilitators pharmacists encounter when pursuing deprescribing recommendations and initiatives with prescribers, healthcare staff, patients, and caregivers. Findings from this study revealed three key implications …

Exploring Teachers' Mastery And Use Of Minecraft In The Classroom A Survey Of The Minecraft Teachers, Hae Ryung Rinpoche Kim

Theses and Dissertations

This study explored the dynamic interplay of social constructivism, game-based learning, and communities of practice in the context of teachers using Minecraft as an educational tool. This study used a teacher survey to collect insights from teachers who use Minecraft and are members of the Minecraft Teachers’ Lounge. The research investigated how teachers learn to use Minecraft, the resources that support their learning journey, and the factors influencing their confidence in utilizing game-based learning tools. The findings highlighted the significance of collaborative learning environments, experiential learning approaches, and ongoing professional development opportunities for teachers using technology-enhanced tools like Minecraft. The …

Veterans, Providers, Moral Injury, And The Integration Of Spirituality In Clinical Care, Claire Muldrew

Theses and Dissertations

Moral Injury (MI) is known to be prevalent among military populations, however, the integration of spirituality into the treatment of veterans with trauma/posttraumatic stress disorder (PTSD) is an understudied topic. This systematic review sought to explore how mental health clinicians and chaplains view the integration of spirituality in the course of clinical care with traumatized veterans who experience MI. Utilizing qualitative methodology, the existing knowledge base was studied to shed light on this topic and to also identify the similarities and differences between these types of providers. The meta-aggregation approach was applied to analysis of the available data and a …

Lifting The Voices Of Cisgender Female Survivors Of Sexual Violence: A Systematic Review Of Their Experiences With Formal Support Providers/Systems, Madeleine Walker

Theses and Dissertations

This qualitative systematic review aimed to recognize what adult cisgender female survivors of sexual violence said about their experiences with formal support providers upon disclosure and their recommendations to enhance the disclosure process. Using a deductive content analysis of nice qualitative studies, the researcher identified and explored supportive and unsupportive formal support providers’ behaviors. Results indicated that supportive experiences typically involved aspects of both emotional support and tangible aid. Unsupportive experiences mainly focused on how providers responded to and negatively treated cisgender female survivors during the entirety of the investigation process. Also, cultural factors, such as race, gender, ethnicity, and …

Making The Middle Matter: Considering Project-Based, Experiential, And Work-Based Instructional Strategies With Middle School Teachers, Trishauna Pulos

Theses and Dissertations

Middle school is about the growth, potential, and change of adolescents. Students at the middle school age level, generally ages 10 to 14, struggle with the dynamics of making the transitions from recess and active learning in elementary school to multiple teachers, bigger workloads and campuses, and larger student populations (Alexander et al., 1969; Howell et al., 2016). For this study, the instructional practices, and strategies of project-based, experiential, and work-based learning are researched including challenges, measurements of growth and success, and recommendations for future educators using these instructional delivery methods (Dincer, 2021; Flannery & Smith, 2021; Kalkan & Dagli, …

Psychotherapeutic Interventions For Individuals Experiencing Auditory Verbal Hallucinations: A Systematic Review, Keren Shemesh

Theses and Dissertations

The objective of this review was to systematically review the available research on psychotherapeutic interventions for individuals experiencing Auditory Verbal Hallucinations (AVH). This review focused on interventions evaluated using Randomized Control Trials (RCTs). Data on the treatment protocols and their efficacy was reviewed, as well as proposed mechanisms of change. Included treatment protocols were evaluated for their attention to culture. Using specific search criteria, 17 studies were identified and evaluated. Out of the 17 included studies, three utilized individual and group Cognitive Behavioral Therapy for Psychosis (CBTp) as their intervention of choice and six utilized individually created therapies based upon …

The Impact Social Support And Community-Based Programs Have On The Reduction Of Recidivism, Lysa Lynnette Liggins

Theses and Dissertations

Recidivism is defined as the tendency for an individual to relapse into criminal behavior after being incarcerated. This poses a challenge to the criminal justice system and there is a growing recognition of the role that receiving social support plays in decreasing the rate of recidivism. This research provides a comprehensive review of the literature that examines the impact of social support on reducing recidivism. This study reviews and synthesizes findings about community-based programs’ positive impact on formerly incarcerated individuals. Also, it explores the five components of social support: emotional support, informational support, tangible support, networking support, and affirmation of …

An Examination Of Emerging Technologies In Supply Chain Management And Their Impacts On Efficiency In The Automotive Industry, Wafaa A. Barakat

Theses and Dissertations

The automotive supply chain sector is facing immense transformation, particularly with the emerging digital technologies in supply chain management. This paper examines the emerging technologies in supply chain management and their impacts on efficiency in the automotive industry. This research strives to examine the underlying aspects of the automotive supply chain integration in United States companies. For the study, there is the application of the exploratory study. The reason is that there is no vivid perspective of the characteristics and the scope. The study design used is a qualitative analysis of 10 automotive personnel from different multipliers of the automotive …