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Articles 108721 - 108750 of 1330606
Full-Text Articles in Entire DC Network
The Teapot Dome Scandal: The Supreme Court's Precedent That Changed The Political Corruption Prosecution Because Of Social Pressure, Jesus R. Jimenez-Andrade
The Teapot Dome Scandal: The Supreme Court's Precedent That Changed The Political Corruption Prosecution Because Of Social Pressure, Jesus R. Jimenez-Andrade
All Faculty Scholarship (Archived)
No abstract provided.
Facilitating Digitization And Reformatting Via Committee Work, Nicole Lewis, Abby Beazer, Marissa Bischoff, Michael F. Gates, Benjamin Harry, Lindsey Memory, Rebecca A. Wiederhold
Facilitating Digitization And Reformatting Via Committee Work, Nicole Lewis, Abby Beazer, Marissa Bischoff, Michael F. Gates, Benjamin Harry, Lindsey Memory, Rebecca A. Wiederhold
Faculty Publications
The Reformatting Committee at Brigham Young University Library actively manages and facilitates the digitization of library materials, playing a pivotal role in advancing larger digitization projects. The committee comprises various stakeholders in the digitization and reformatting workflow, each with unique concerns and requirements, allowing the committee to effectively navigate the complexities of the digitization process. This exploration of the committee includes motivations for its formation, an explanation of its documentation, and the benefits gained.
The Reformatting Committee exemplifies a balanced approach to meeting various stakeholders’ expectations and building bridges between departments, thereby advancing the library’s mission in the context of …
Banking And Antitrust, Saule T. Omarova, Graham S. Steele
Banking And Antitrust, Saule T. Omarova, Graham S. Steele
Faculty Publications
Money is power. Banks have the extraordinary power to create the nation’s money and credit, which they are entrusted to channel into productive economic uses. Like most other forms of economic power, this publicly granted privilege can be abused for private gain. That is why the “money monopoly” and “money trusts” were once considered one of the most dangerous forms of concentrated private wealth, an existential threat to economic freedom and American democracy. Yet, for the past half-century, the law governing banks and the law curbing monopolies have occupied doctrinally and normatively separate spaces. Today, banking law is seen predominantly …
"The Only Disability In Life Is A Bad Attitude": A Quantitative Exploration Of The Impacts Of Inspiration Porn, Anna H. Burt, Megan Mccarty
"The Only Disability In Life Is A Bad Attitude": A Quantitative Exploration Of The Impacts Of Inspiration Porn, Anna H. Burt, Megan Mccarty
Modern Psychological Studies
Inspiration porn is a social media representation of visibly disabled individuals performing physical activities accompanied by short motivation captions meant to inspire viewers. Critics of inspiration porn hold that it misrepresents the reality of disability and negatively impacts disabled people. This study aimed to quantitatively explore the impacts of inspiration porn on various disability-related variables, as there is limited research on this topic. We hypothesized that exposure to inspiration porn would increase system justification and belief in a just world, decrease support for disability-related policies, and cause viewers to view disabled individuals as sources of inspiration. We also had several …
The Impact Of Parent-Child Interactions On Emotion Regulation In Adulthood, Bridget Burgoyne, Holly Grant-Marsney
The Impact Of Parent-Child Interactions On Emotion Regulation In Adulthood, Bridget Burgoyne, Holly Grant-Marsney
Modern Psychological Studies
Childhood is a time where emotional skills are formed. These skills often reflect the primary caregiver(s) modeling and interactions which may shape emotional intelligence. This research aimed to assess if specific parenting approaches have lasting effects on a person’s ability to emotionally regulate. The sample included 141 adults, who responded to questions reflecting the parenting approaches they observed, and their current state of emotional regulation. Results from our regression analysis showed when controlling for age, parental warmth in childhood predicted one’s later ability to use cognitive reappraisal skills. Results from our correlational analysis showed strong positive associations between overindulgence, cognitive …
Motivated Gifts: A Self-Determination Perspective, Sharise Love, Liudmila Titova
Motivated Gifts: A Self-Determination Perspective, Sharise Love, Liudmila Titova
Modern Psychological Studies
Gift-giving can strengthen relationships and facilitate favor requests. Previous researchers have found that 'motivated gifts' (gifts given with the intention of asking a favor) decrease recipients' satisfaction and willingness to help. The current study investigated the role of basic psychological need satisfaction (BPNS) in this effect. BPNS is said to facilitate the integration of autonomous motivation, which was hypothesized to mediate the relationship between motivated gifts and prosociality. In the current study, a sample of 426 undergraduate students was randomly given a hypothetical scenario in which they imagined receiving a motivated gift or not, while also being asked a favor. …
Body Dissatisfaction In College Students: Which Sociocultural Pressure Best Predicts Drive For Thinness?, Sawyer V. Ellis, Elaine M. Kozmiuk, Mary E. Pritchard, Heather Schoenherr
Body Dissatisfaction In College Students: Which Sociocultural Pressure Best Predicts Drive For Thinness?, Sawyer V. Ellis, Elaine M. Kozmiuk, Mary E. Pritchard, Heather Schoenherr
Modern Psychological Studies
Previous literature has suggested that family pressure is the main predictor of drive for thinness (Palladino Green & Pritchard, 2003). Given the growth of social media where thin beauty is glamorized, we wanted to test if this remains true while including multiple factors that may have been disregarded in body-centric studies. Consequently, we asked which sociocultural pressure—family, peers, or media—relates the strongest with body shame, body surveillance, and drive for thinness. A sample of 1,049 undergraduate psychology students, ages 18-29, were surveyed to better understand body dissatisfaction in college students. We predicted that each sociocultural pressure would correlate with body …
Body Image And Social Media In College Students, Elaine M. Kozmiuk, Sawyer Ellis, Mary Pritchard, Heather Schoenherr (Mentor)
Body Image And Social Media In College Students, Elaine M. Kozmiuk, Sawyer Ellis, Mary Pritchard, Heather Schoenherr (Mentor)
Modern Psychological Studies
The current study assessed the relationship between social media appearance-related preoccupation (SMARP), body shame, body surveillance, and social physique anxiety (SPA). Data were collected from 1,049 participants, and a correlational analysis and a hierarchal regression were conducted. Significant relationships were found between body shame, body surveillance, SMARP, and SPA, supporting our hypotheses. Our results confirmed the relationship between SPA and SMARP, adding evidence to a mixed debate about the relationships between SPA and social media use. The researchers found that SPA moderated the relationship between body shame and SMARP. We can conclude that appearance anxieties and appearance-based social media use …
Interactions Between Anxiety, Family Influence, And Athletic Status On College Students: A Military School Cohort, Caragh Osborne, Aubrey Whitehead
Interactions Between Anxiety, Family Influence, And Athletic Status On College Students: A Military School Cohort, Caragh Osborne, Aubrey Whitehead
Modern Psychological Studies
The prevalence of anxiety in college students has increased drastically over the past decade. Previous researchers have typically only examined how to help students while they are at school, however, there could be additional factors contributing to their anxiety prior to attending college. The current study aimed to observe how family influence and athletic status may play a role in anxiety among college students. Participants (N = 42) completed an anxiety symptoms inventory then disclosed how much their family influenced their decision to attend college. A two-way ANOVA indicated that neither athletic status nor degree of family influence had a …
Review Of The Cavity Effect: Modeling And Impact Of Cavity Shape On Apparent Radiative Surface Properties, Ehsan Mofidipour, Matthew R. Jones, Brian D. Iverson
Review Of The Cavity Effect: Modeling And Impact Of Cavity Shape On Apparent Radiative Surface Properties, Ehsan Mofidipour, Matthew R. Jones, Brian D. Iverson
Faculty Publications
Radiative surface properties play a critical role in the analysis, design, and optimization of thermal systems. Geometry has a strong influence on the emission and absorption characteristics of a surface. Modification of radiative surface properties may be achieved by using engineered surfaces or cavities by capitalizing on the cavity effect. A model for the apparent emissivity of an arbitrarily shaped cavity with spectrally and directionally dependent radiative surface properties is presented in this work. This model is verified through comparison with published models of the apparent radiative properties of cylindrical cavities. The merit of this model is demonstrated by obtaining …
Random Forests Regression For Soft Interval Data, Paul Gaona-Partida, Chih-Ching Yeh, Yan Sun, Adele Cutler
Random Forests Regression For Soft Interval Data, Paul Gaona-Partida, Chih-Ching Yeh, Yan Sun, Adele Cutler
Mathematics and Statistics Faculty Publications
Analyzing soft interval data for uncertainty quantification has attracted much attention recently. Within this context, regression methods for interval data have been extensively studied. As most existing works focus on linear models, it is important to note that many problems in practice are nonlinear in nature and the development of nonlinear regression tools for interval data is crucial. This paper proposes an interval-valued random forests model that defines the splitting criterion of variance reduction based on an L2 type metric in the space of compact intervals. The model simultaneously considers the centers and ranges of the interval data as …
Review Of Computational Models For Large-Scale Mdao Of Urban Air Mobility Concepts, Darshan Sarojini, Marius L. Ruh, Jiayao Yan, Luca Scotzniovsky, Nicholas C. Orndorff, Ru Xiang, Han Zhao, Joshua J. Krokowski, Michael Warner, Sebastiaan Pc Van Schie, Ashley Cronk, Alexandre T. R. Guibert, Jeffrey T. Chambers, Lauren Wolfe, Rachel Doring, Robin Despins, Cibin Joseph, Ryan Anderson, Andrew Ning, Hyunjune Gill, Seongkyu Lee, Zeyu Cheng, Zhi Cao, Chunting Mi, Y Shirley Meng, Christopher Silva, Jiun-Shyan Chen, H. Alicia Kim, John T. Hwang
Review Of Computational Models For Large-Scale Mdao Of Urban Air Mobility Concepts, Darshan Sarojini, Marius L. Ruh, Jiayao Yan, Luca Scotzniovsky, Nicholas C. Orndorff, Ru Xiang, Han Zhao, Joshua J. Krokowski, Michael Warner, Sebastiaan Pc Van Schie, Ashley Cronk, Alexandre T. R. Guibert, Jeffrey T. Chambers, Lauren Wolfe, Rachel Doring, Robin Despins, Cibin Joseph, Ryan Anderson, Andrew Ning, Hyunjune Gill, Seongkyu Lee, Zeyu Cheng, Zhi Cao, Chunting Mi, Y Shirley Meng, Christopher Silva, Jiun-Shyan Chen, H. Alicia Kim, John T. Hwang
Faculty Publications
The advent of Urban Air Mobility (UAM) has necessitated a paradigm shift in aircraft design from traditional regression methods to physics-based analysis and the use of modern computational methods. This paper explores the intricacies of UAM aircraft design, acknowledging the limitations of historical empirical equations and advocating for the use of physics-based tools in the early stages of the design process. It underscores the importance of Multidisciplinary Design, Analysis, and Optimization (MDAO) as a means to integrate physics-based tools for conceptual design, facilitating decisions on configuration and sizing. The paper presents a comprehensive survey and review of computational models across …
Documents From The February 21, 2024 Meeting Of The Associated Students Of The University Of Montana (Asum), University Of Montana--Missoula. Associated Students
Documents From The February 21, 2024 Meeting Of The Associated Students Of The University Of Montana (Asum), University Of Montana--Missoula. Associated Students
Senate Meeting Agendas and Minutes, 2007-Present
Agenda and meeting minutes from the February 21, 2024 meeting of the Associated Students of the University of Montana (ASUM). The following resolutions were discussed during the meeting:
SB17-23/24: Resolution Revising Article IV, Section 14 of the ASUM Bylaws
SB16 -23/24: Resolution Commending UM BSU President Jasmine Caldwell
An Overview Of Youth Crime And Violence In The Caribbean Community (Caricom), Marika Dawkins-Cavazos
An Overview Of Youth Crime And Violence In The Caribbean Community (Caricom), Marika Dawkins-Cavazos
Criminal Justice Faculty Publications
No abstract provided.
Muscle-Nerve Signaling And Its Role In Myogenesis, Synaptogenesis, And Regeneration, James T. Redden
Muscle-Nerve Signaling And Its Role In Myogenesis, Synaptogenesis, And Regeneration, James T. Redden
Theses and Dissertations
Despite only comprising 0.1% of the myofiber surface area, a healthy motor endplate is densely packed with acetylcholine receptors (AChRs) responsible for mediating activity between the connected motor neuron and skeletal muscle via the neurotransmitter, acetylcholine. Loss of the endplate, known as fragmentation, is caused by car crashes, deep lacerations, and other traumatic injuries to the innervating nerve or direct injuries to the limb muscle(s) with intramuscular denervation as a common comorbidity. In both cases, endplate fragmentation begins within a week of injury proceeding muscle atrophy causing decreased mobility, paralysis, and quality of life. Endplate fragmentation of intact muscle fibers …
Voltage Control Of Interfacial Magnetism For Energy-Efficient Skyrmion-Based Memory And Neuromorphic Computing, Md Mahadi Rajib
Voltage Control Of Interfacial Magnetism For Energy-Efficient Skyrmion-Based Memory And Neuromorphic Computing, Md Mahadi Rajib
Theses and Dissertations
The data generated annually has reached unprecedented levels, necessitating the integration of energy-efficient computing systems to achieve high performance and sustain our society’s computing needs. Specifically, energy-efficient computing, once considered advantageous, has now become essential in managing this exponential data growth. For example, the energy used solely by Google was equivalent to the energy consumed by a country with population >20 million in 2019 and this energy need is increasing exponentially [1]. Therefore, high-performance computing systems with energy-efficient, faster operability, and scalable computing units are necessary to address present and future computing challenges.
Apart from traditionally used conventional von Neumann …
The Many Impacts Of The Covid-19 Pandemic On Latinx College Students’ Mental Health: Exploring The Role Of Sleep, Social Support, And Familismo, Mayra S. Ramos
The Many Impacts Of The Covid-19 Pandemic On Latinx College Students’ Mental Health: Exploring The Role Of Sleep, Social Support, And Familismo, Mayra S. Ramos
Theses and Dissertations
College students experienced a multitude of disruptions to their daily life, and changes to their physical (i.e., sleep quality) and mental health (e.g., anxiety and depressive symptoms) because of the COVID-19 pandemic. Though the field has identified the factors that have contributed to negative physical and mental health changes, there remains much to be known about social and cultural protective factors that could buffer the negative role of the COVID-19 pandemic on Latinx college students. The current study contributed to the literature on the mental health outcomes of Latinx college students by identifying a possible mediator and moderators between the …
Mild Traumatic Brain Injury In Yucatan Minipigs: Assessing Changes In Approachability And Mechanical Nociception Following Diffuse Central Fluid Percussion Injury, Mark D. Pavlichenko
Mild Traumatic Brain Injury In Yucatan Minipigs: Assessing Changes In Approachability And Mechanical Nociception Following Diffuse Central Fluid Percussion Injury, Mark D. Pavlichenko
Theses and Dissertations
Traumatic brain injury (TBI) is a major healthcare concern affecting millions. Symptoms of TBI include sensory sensitivity and social changes that may persist long-term. Due to similarities in cytoarchitecture, metabolism, and inflammation, higher order minipig models are advantageous for translational TBI research, however, there remains a shortage of information regarding their behavioral and sensory sequelae following injury. Therefore, in this study, we assessed changes in sociability and somatosensation in adult male and female Yucatan minipigs for up to one-week following a sham or central fluid percussion injury (cFPI). Specifically, the voluntary human approach task (VHAT) and the forced human approach …
Supported Metal Nanoparticle Synthesis: Precursor Deposition And Agglomeration At Support Surfaces, Edward H. Chandler Jr.
Supported Metal Nanoparticle Synthesis: Precursor Deposition And Agglomeration At Support Surfaces, Edward H. Chandler Jr.
Theses and Dissertations
Catalysis is a critical component of the chemical manufacturing industry. For example, it has been estimated to be essential to more than 90% of the major industrial processes developed during the middle years of the 20th century.1 Heterogeneously supported transition metal catalysts in particular have many benefits such as easy separability from the reaction mixture and high thermal stability. One method of synthesizing these is wet impregnation, wherein a metal solution is brought into contact with an oxide- or carbon-based powder. Given optimal environmental conditions, a metal will adhere to the surface through electrostatic means in a process …
Machine Learning Assisted Optimization For Calculation And Automated Tuning Of Antennas, Lauren Linkous
Machine Learning Assisted Optimization For Calculation And Automated Tuning Of Antennas, Lauren Linkous
Theses and Dissertations
The Antenna Calculation and Autotuning Tool (AntennaCAT) software suite represents a significant advancement in the field of antenna design by automating the entire design, CAD, simulation, and optimization process compatible with several EM simulation software suites. It is the first comprehensive implementation of machine learning in this context. In particular, this work includes the capability to create and export structured datasets from the aforementioned EM software for iterative improvement and includes an expandable selection of optimizers.
Applying X-Ray Fluorescence With Monte Carlo Methods For Analysis Of Surface Defects On Coated Zr4, James Tyler Cahill
Applying X-Ray Fluorescence With Monte Carlo Methods For Analysis Of Surface Defects On Coated Zr4, James Tyler Cahill
Theses and Dissertations
Chromium-coated Zircaloy-4 cladding represents a novel solution for creating nuclear cladding that has passive safety features. This and related developments aimed at improving nuclear safety are broadly categorized as accident-tolerant fuel and cladding. However, implementing this material presents practical challenges such as the vulnerability that cladding has to surface damage such as fretting wear. This research aims to determine if the pre-existing technique of X-ray fluorescence analysis is applicable for detecting these defects on the surface of the cladding. This was done by developing Monte Carlo N-Particle Transport models of a handheld device, the XL-5, alongside experimental measurements using this …
Trait Mindfulness And Political Polarization: Investigating Neural Responses And Emotional Orientations, Elif Z. Celik
Trait Mindfulness And Political Polarization: Investigating Neural Responses And Emotional Orientations, Elif Z. Celik
Theses and Dissertations
The rapid escalation of political polarization has led to increased social distancing, aggressive partisan behavior, and discriminatory attitudes among Democrats and Republicans. Prior research has indicated that mindfulness is associated with increased compassion, reduced prejudice, and diminished aggression toward out-group members. This thesis investigates the relationship between trait mindfulness and political polarization by examining neural responses and emotional orientations in individuals with varying levels of mindfulness. This research measured brain activity using functional near-infrared spectroscopy (fNIRS) while participants viewed emotionally charged political videos and neutral content. The primary hypothesis suggested that individuals with high trait mindfulness would exhibit left-lateralized prefrontal …
Evaluation Of Alternative Methods For Dna Recovery Of Compromised Skeletal Remains, Ciara N. Rhodes
Evaluation Of Alternative Methods For Dna Recovery Of Compromised Skeletal Remains, Ciara N. Rhodes
Theses and Dissertations
Skeletal remains frequently serve as the sole source of genetic material available for developing a profile in cases concerning unidentified human remains or mass casualties. Nevertheless, as unidentified skeletal remains age and are exposed to uncontrolled environmental conditions, the success rates of conventional methods of bone analysis diminish significantly. The physical and mechanical processing of skeletal remains into fine powder for DNA isolation and downstream analysis can substantially impact the quality and quantity of recoverable genetic information. This concern may be exacerbated when dealing with degraded forensic skeletal remains. Few studies have explored whether pulverization of bone samples contributes to …
Title: I: L1-Norm Matrix Completion For Recommender Systems Ii: Conjecturing-Based Classification, Fatemeh Valizadeh Gamchi
Title: I: L1-Norm Matrix Completion For Recommender Systems Ii: Conjecturing-Based Classification, Fatemeh Valizadeh Gamchi
Theses and Dissertations
Recommendation systems are essential for providing personalized user experiences, but their performance can be affected by outliers especially in traditional collaborative filtering methods that use the L2-norm. To address this challenge, we developed two new algorithms, SharpEl1rs and SharpEl1rs-Impute, based on the L1-norm to improve resistance against extreme values and effectively handle missing data. Our experimental setting was designed to compare these proposed methods with existing techniques. Then our algorithms are applied to real datasets to assess their performance, with findings indicating that our proposed models offer improved accuracy in some cases and solid performance in others for industrial-scale recommendation …
The Role Of Hdac6 In Periodontal Inflammation, Hannah S. Lohner
The Role Of Hdac6 In Periodontal Inflammation, Hannah S. Lohner
Theses and Dissertations
Periodontal disease is a polymicrobial infection-induced chronic inflammatory disease and results in irreversible tissue damage and bone loss. While bacteria play a large role in the initiation of this disease, excessive and prolonged inflammatory immune responses are fundamental for its progression, making host directed therapy (HDT) a possible and potentially valuable treatment. Histone Deacetylase 6 (HDAC6) is an enzyme that removes acetyl groups from both histone and non-histone proteins, giving it a potential role in regulating inflammation initiated by pathogenic oral bacteria. Previous studies indicated that HDACs act as a bivalent regulator in inflammatory responses; however, the role that HDAC6 …
Repeated-Measures Latent Profile Analyses Of Intervention Fidelity To A Teacher-Delivered Intervention Program For Children At Elevated Risk For Emotional And Behavioral Disorders, Katrina A. Markowicz
Repeated-Measures Latent Profile Analyses Of Intervention Fidelity To A Teacher-Delivered Intervention Program For Children At Elevated Risk For Emotional And Behavioral Disorders, Katrina A. Markowicz
Theses and Dissertations
Teachers have difficulty delivering Tier-2 intervention programs for preschoolers at elevated risk for socioemotional and behavioral disorders with high intervention fidelity (Durlak, 2010; Sutherland et al., 2018). Several proximal factors that impact program fidelity have been identified, which may undermine program effects (Domitrovich et al., 2008; McLeod et al., 2022; Sutherland et al., 2018). Therefore, researchers have identified strategies, such as practice-based coaching, to improve intervention fidelity and support teachers (Hemmeter et al., 2015; Synder et al., 2015). Most of the field's knowledge of these topics is limited to variable-centered approaches (Fettig et al., 2022; Low et al., 2016). However, …
Not Woman Enough: How World Athletics’ Treatment Of Women With Differences In Sexual Development Violates The Olympic Charter And The Un’S Conventions Against Racial Discrimination And Discrimination Against Women, Rachel Crass
Denver Journal of International Law & Policy
In 1966, in response to growing fears that men would attempt to pose as women to win medals in elite competition, the International Olympic Committee (IOC) began gender testing all female athletes through various visual and gynecological evaluations. These tests were quickly deemed to be too invasive and were replaced by other chemical and genetic tests as scientific capabilities advanced. The new tests led to the disqualification of dozens of elite female athletes after results revealed latent Y chromosomes in women with androgen insensitivity conditions. After multiple leading medical societies and international sports governing bodies called for an end to …
Menstrual Hygiene Management And The Right To Education In Ethiopia, Krista Jolivette
Menstrual Hygiene Management And The Right To Education In Ethiopia, Krista Jolivette
Denver Journal of International Law & Policy
This Note focuses on the nation of Ethiopia as an example of modern issues in menstrual hygiene management, calling upon existing measures of implementation and recommendations for future interventions. The Note concludes by pointing out that progress in this arena is possible with the help of government agents, NGOs, and international actors.
Functional Monitoring For Run-Time Assurance Of A Real-Time Cyber Physical System, Matthew W. Gelber
Functional Monitoring For Run-Time Assurance Of A Real-Time Cyber Physical System, Matthew W. Gelber
Theses and Dissertations
As cyber-physical systems (CPS) become more integrated into everyday life, the security of these systems must also be considered during their development due to their ever-increasing importance. With the growth of physical components in the system, more autonomous control requirements, and increased dependence on proper functionality, verifying system safety and correct operation becomes increasingly difficult. CPS have become more complex through the combination of additional hardware and the resulting interconnected software in many layers, each requiring unique security solutions. One example of such a safety-critical CPS embedded system is the Flight Control System (FCS) of an Unmanned Aerial System (UAS). …
Utilizing Hemoglobin Binding Kinetics And X-Ray Crystallography In Sickle Cell Disease Drug Development, Ahmed Alghamdi
Utilizing Hemoglobin Binding Kinetics And X-Ray Crystallography In Sickle Cell Disease Drug Development, Ahmed Alghamdi
Theses and Dissertations
ABSTRACT
UTILIZING HEMOGLOBIN BINDING KINETICS AND X-RAY CRYSTALLOGRAPHY IN SICKLE CELL DISEASE DRUG DEVELOPMENT
By Ahmed Alghamdi, M.Sc. in Medicinal Chemistry
A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Medicinal Chemistry at Virginia Commonwealth University.
Virginia Commonwealth University, 2024.
Director: Dr. Martin K. Safo Professor, Department of Medicinal Chemistry
Introduction: Sickle Cell Disease (SCD) is characterized by severe hemolytic anemia, recurrent painful crises, and chronic organ damage, posing significant challenges to patients' quality of life and longevity. While current FDA-approved therapies offer symptomatic relief, they do not address the underlying molecular …