Digital Commons Network^™

Prevalence, Determinants, And Objective Risk Of Unintentional Therapeutic Duplication Among Adults In Saudi Arabia, Yosra Alhindi

Saudi Toxicology Journal

Background: Unintentional therapeutic duplication represents an underrecognized yet preventable contributor to medication-related harm, particularly in settings characterized by widespread over-the-counter (OTC) medicine use and self-medication practices. Objective: To estimate the prevalence of unintentional therapeutic duplication among adults in Saudi Arabia and identify sociodemographic and behavioral predictors associated with increased therapeutic duplication risk. Methods: A national crosssectional study was conducted between February 10 and April 28, 2025, using a structured, self-administered online questionnaire distributed via social media platforms. The survey assessed sociodemographic characteristics, medication-use behaviors, active-ingredient literacy, and duplication risk using both self-reported measures and scenario-based assessments. Multivariable logistic regression was …

Fiber Consumption Of Three Lemur Species With Varying Dietary Specializations, Dylan Daniels

Honors Capstones

Fiber is an important macronutrient as a source of energy for maintaining animal health. My research question is what is the fiber content of foods consumed by lemur species with different dietary specializations (Propithecus diadema, Eulemur fuvlus, and Hapalemur griseus) and are there seasonal changes? 172 plant foods were collected in Tsinjoarivo, Madagascar during the resource-abundant and lean season. I analyzed these samples using the neutral detergent fiber method, which simulates digestion and measures insoluble fiber. Knowing how much fiber lemurs consume and how they adapt to seasonal variation in the food supply will allow for restorative actions to be …

Taoism As Applied To The Individual In Western Business, Alfie T. Chadwick

Honors Capstones

When making the comparisons between Eastern and Western approaches, the primary focus of juxtaposition is the “this or that” attitude of Western thought against the “this into that” focus of Eastern thought. For instance, a Western company may view change as the opposite of stability whereas Taoist belief through Yin-Yang theory suggests change actually is stability (Chen, 2002).

The inherent paradoxical nature of this approach counters most Western schools of thought and, therefore, might prove difficult to implement in a Western workplace. This study aims to explore the potential for applying the principle of Wu-Wei (also known as “effortless action”) …

A Retrospective Look At Self-Reported Mental Health Prevalence In Division Iii Student-Athletes, Jacob F. Neri

Masters Theses/Capstone Projects

Mental health concerns among collegiate athletes have gained increased attention, but there has been limited research focus on Division III student-athletes. This study aimed to examine the self-reported prevalence of anxiety, depression, anger, stalking/harassment, abuse/assault, alcohol/substance abuse, self-harm, suicide ideation, and suicide attempt to identify contributing factors amongst this population. A retrospective, cross-sectional study was conducted looking at data collected from the student-athlete mental health history & well-being questionnaire that was administered as part of their pre-participation exam (PPE) prior to the beginning of each academic year. A total of 554 Division III student-athletes were included in the study. Results …

Machine Learning For Handwritten Character Recognition, Hannah Freitag

Honors Capstones

Handwritten character recognition remains a challenging problem in machine learning due to the high variability of handwriting across individuals and the visual similarity between certain character classes. This project explores whether Singular Value Decomposition (SVD)-based dimensionality reduction can serve as an effective preprocessing step for a fully connected neural network trained on the EMNIST Balanced dataset, a 47-class benchmark of handwritten digits and letters. By projecting 784- dimensional pixel inputs onto the top 70 principal components, approximately 90% of the total variance is preserved while reducing input dimensionality by 91%. The resulting SVD-based model achieves approximately 94% test accuracy, outperforming …

Assessing The Risk Of Low Energy Availability In Ncaa Division Iii Female Soccer Players, Emma C. Sturts

Masters Theses/Capstone Projects

Low Energy Availability (LEA) can occur when an athlete’s energy intake is insufficient to meet the physiological demands of training as well as normal physiological functions. Female soccer players may be at an increased risk of developing LEA due to the high exercise energy expenditure paired with decreased energy intake. The purpose of this study is to assess the prevalence of LEA among Division III female soccer players. Division III female soccer players (n = 11) completed the Low Energy Availability in Females Questionnaire (LEAF-Q). 45.5% (n = 5) of the participants were classified as “At Risk” for LEA. Of …

Investigating The Prevalence Of Eating Disorder Risk And Body Image Dissatisfaction Among Division Iii Track And Field Athletes, Ravyn S. Goodson

Masters Theses/Capstone Projects

Context: Eating disorder (ED) risk, and body image dissatisfaction (BID) are increasingly recognized concerns in collegiate athletes due to sport-specific and sociocultural pressures. However, limited research has looked at these factors within NCAA Division III track and field athletes.

Objective: To examine the prevalence of eating disorder risk and body image dissatisfaction among division III track and field athletes and explore differences based on gender and event group Design A quantitative, cross-sectional survey design

Setting: NCAA division III athletic program within the Ohio Athletic Conference (OAC), during the 2025-2026 competitive season.

Participants: A total of 32 NCAA Division III track …

Is More Better? The Influence Of Visual Entropy And Color On Brand Identity And Engagement, Maryana Kopyt

Honors Capstones

Brands in the beauty industry rely heavily on visual content to differentiate themselves and communicate their identity on social media. However, it remains unclear how visual complexity affects consumer engagement and perceptions, and limited research has combined visual entropy, sentiment, and engagement.

This project examines how three beauty brands: Glossier, Rhode, and Clinique, use color and visual complexity in their Instagram content and how these different strategies relate to emotional tone, brand identity consistency, and consumer engagement. A dataset of approximately 150 posts was collected, and deep learning-based visual analysis was used to extract the dominant colors and calculate visual …

Woodward Cuk Converter, Aditi Venkatesh, Jennifer Pereira

Honors Capstones

The purpose of this senior design project is to design and build a Cuk converter, a type of buck–boost converter. The project involves developing an analytical model and validating it through hardware testing. Cuk converters are important because they are widely used in everyday electronics, particularly in renewable energy systems such as solar power, power supplies, and electric vehicles. Their ability to increase, decrease, and reverse the polarity of voltage makes them flexible. The continuous input and output currents result in low ripple, reducing component stress and improving efficiency. To achieve these goals, simulations will be conducted using LTspice to …

Effect Of Exergaming Duration On Heart Rat And Caloric Expenditure In Healthy Older Adults, Kathryn Jade Johnson

Honors Capstone Projects and Theses

No abstract provided.

The Effect Of Stress Hormones On Memory Formation And Academic Performance, Emma L. Hooks

Senior Honors Theses

With chronic stress becoming increasingly prevalent in academic settings, researchers have identified significant effects on learning and academic performance. Cortisol, a glucocorticoid hormone, is released following the activation of the hypothalamic-pituitary-adrenal (HPA) axis and plays a vital role in the stress response. Although acute increases in cortisol can improve attention and memory, sustained activation of the stress response can impair memory, executive functioning, and academic performance. This thesis draws on neuroscience, psychology, and education research to examine how chronic cortisol exposure affects the hippocampus and prefrontal cortex, and how the effects manifest in learning and academic performance, particularly in developmental …

Tropomyosin-Related Kinase Receptor Type B Agonism In Geographic Atrophy-The Translational Challenges From Preclinical Data To A First-In-Human Trial, David Brown, Oliver Zeitz, Clare Bailey, Sunir J. Garg, Karl Csaky, James Talks, Sobha Sivaprasad, Peter M. Benz, Rolf Herrmann, Remko A. Bakker, Sebastian Bandholtz, Ankit Mittal, Qihong Huang, Serge Kosobokovs, Gudrun Simons, Andrea Giani, Jochen Huber, Martin Gliem

Wills Eye Hospital Papers

OBJECTIVE: To report results of the first-in-human trial of intravitreal tropomyosin-related kinase receptor type B (TrkB) agonist BI 754132 in participants with geographic atrophy (GA). To discuss BI 754132 clinical data in the context of the preclinical findings and their translation into human data.

DESIGN: An open-label, uncontrolled, nonrandomized phase I trial (NCT04002310) assessing the safety, tolerability, and pharmacokinetics of BI 754132 in participants with GA supported by preclinical data.

PARTICIPANTS: Participants with GA recruited between July 2019 and August 2022 in the United States and UK.

METHODS: Clinical trial comprising a single rising dose (SRD) part (n = 15) …

Comparing The Effectiveness Of Neb Precrtm Repair Mix And Nxgen T4 Dna Ligase For Repairing Degraded Dna For Pcr Forensic Applications, Karolena Zvokel

Honors Theses

This study investigated the comparison between using PreCRTM mix (New England Biolabs) and T4 DNA Ligase (New England Biolabs) to repair degraded forensic whole blood DNA samples for PCR amplification. Degraded DNA presents a significant challenge in forensic STR analysis due to reduced amplification efficiency and allele imbalance. Whole blood samples were extracted, quantified, and artificially degraded using UV exposure. Samples were introduced to multiple treatments, including no damage no repair (NDNR), damage no repair (DNR), PreCRTM repair, T4 DNA ligase treatment, and combined repair approaches. Amplified products were analyzed using capillary electrophoresis, and peak height ratios (PHR) were used …

A.I. And The Law: How Ethical Guidelines Affect The Use Of Artificial Intelligence In Legal Work, Andre Asher

Honors Theses

Artificial intelligence is a quickly growing industry that is beginning to integrate itself into various aspects of our lives. Regarding the legal portion, the American Bar Association has an extensive set of ethical guidelines which, although they themselves do not hold any disciplinary weight, have been adapted to many state grievance committees where sanctions can be imposed. The use of AI in the legal field has introduced a whole new set of ethical concerns, which the already existing rules of professional conduct must now adapt to. Looking at the ABA’s ethical rules 1.1: Competency, 1.3: Diligence, 1.5: Fees, 1.6: Confidentiality, …

Employing Zebrafish To Understand Genetic Drivers Of Epilepsy-Related Comorbid Behaviors, Chinwendu Ononuju, Kharma Hall, Olivia Beatty, Scott C. Baraban, Colleen Carpenter-Swanson

Biology Faculty Publications

Children with epilepsy frequently experience a range of significant comorbidities beyond seizures, such as motor dysfunction, cognitive impairment, and neurodevelopmental delays. In some cases, these comorbidities contribute more significantly to overall disease burden than the seizures themselves. To improve quality-of-life (QOL) for these children, treatment options should be selected that control seizures and ameliorate comorbidities. Unfortunately, such therapeutics remain largely elusive. Addressing this issue requires suitable preclinical models. Here we used CRISPR-generated zebrafish with single-gene mutations linked to pediatric epilepsy and applied clinically-relevant behavioral assays to study the effects of these mutations. Using high-throughput locomotion-based assays, we uncovered errors in …

Tractor Workflow: A Scalable Nextflow Framework For Local Ancestry-Aware Genome-Wide Association Studies, Nirav N Shah, Taotao Tan, Jessica Honorato-Mauer, Yi-Sian Lin, Adam X Maihofer, Clement C Zai, Pgc-Ptsd Ancestry Working Group, Marcos Santoro, Caroline M Nievergelt, Elizabeth G Atkinson

Faculty, Staff and Students Publications

Motivation: The routine exclusion of admixed individuals from traditional genome-wide association studies (GWAS) due to concerns about spurious associations has limited multi-ancestry genetic discovery. Tractor addresses this issue by incorporating local ancestry into association testing, enabling the identification of ancestry-enriched signals and generating ancestry-specific summary statistics. However, adoption has been constrained by the complexity of prerequisite steps, including phasing and local ancestry inference, which require substantial bioinformatics expertise and introduce key analytical decision points.

Results: We developed a scalable, automated Nextflow workflow that integrates phasing, local ancestry inference, and Tractor association testing into a reproducible end-to-end pipeline. To demonstrate its …

Nuclear Export As A Therapeutic Vulnerability In Zfta-Rela Ependymoma, Siri M Ippagunta, Amir Arabzade, Srinidhi Varadharajan, Erik Emanus, Amanda Bland, Alisha Kardian, Nicholas Laboe, Hua Sun, Tuyu Zheng, Amelia Hancock, Mark Zhai, Emma Caesar, Maxwell Park, Wilda Orisme, Melissa Johnson, Brittany Rodgers, Gregory H Turner, Jeffrey Steinberg, Burgess Freeman, Martine F Roussel, Anang Shelat, Richard Kriwacki, Thomas E Merchant, Benjamin Deneen, Michael D Taylor, Sameer Agnihotri, Shondra Pruett-Miller, Jacob A Steele, Anoop Murthy Kavirayani, David W Ellison, Arzu Onar-Thomas, Giles Robinson, Stephen C Mack, Kelsey C Bertrand

Faculty, Staff and Students Publications

Background: Ependymoma (EPN) is the third most common pediatric brain tumor with no targeted therapies available to patients. In supratentorial ependymoma, the most frequent driver alteration is a gene fusion between ZFTA and RELA (denoted ZR), leads to constitutive localization of ZR in the nucleus. Because ZR is not currently druggable, we tested whether ZR expression leads to aberrant protein interactions that could represent therapeutic vulnerabilities.

Methods: Using CRISPR-Cas9 pooled screening, we identified many novel druggable ZR interacting proteins including XPO1, CARM1, SMARCA4, and CDK1. We focused on the nuclear export protein (XPO1), given the ability of most XPO1 inhibitors …

Extra Of Extracorporeal: Use Of Vv-Ecmo In Complex Tracheal Ring Resection Surgery, Saurabh Ashok Holamb Mr, Ravinath Swami Mr

Journal Of Indian Physician Associates

 Abstract

Background:

Tracheal stenosis may arise from congenital malformation, trauma, prolonged intubation, or malignancy. Surgical correction of such lesions poses a major challenge, especially when airway management becomes difficult due to the location and extent of narrowing.

Case Summary:

We report a case of a 64-year-old male with circumferential thickening of the trachea at the D2–D3 level, exhibiting a 1.3cm long segmental narrowing. The patient underwent tracheal ring resection with veno-venous extracorporeal membrane oxygenation (VV-ECMO) support. Two apnea periods were maintained intraoperatively, totaling 3.5 hours, with stable hemodynamics and 100% oxygen saturation throughout. ECMO support was continued overnight as a …

Reimagining Maternal Health: The Crucial Role Of Social And Behavioural Change Communication In Lmics, Sneha Chetri Ms, Monica Koachar

Journal Of Indian Physician Associates

Preventable maternal mortality is still remarkably high in low and middle-income nations, despite growing investments in maternal health systems. Conventional methods have mostly concentrated on expanding access to services, ignoring important social and behavioural factors that affect how people seek health care. In order to bridge the gap between the availability and actual consumption of maternal health treatments, this opinion piece makes the case for the critical role that social and behavioural change communication plays. The article uses real-world examples from Bangladesh, Nepal, India, Ethiopia, Nigeria, Ghana, and Uganda to show how SBCC can empower women, change the dynamics of …

From Confidence To Competence: Embedding Critical Genai Literacy In Physician Associate Education, Chanceeth Chandrakanthan, Amy H. Donaldson-Perrott Mrs, Jane Secker, Julie Voce, Tamara S. Ritsema

Journal Of Indian Physician Associates

Background: Generative artificial intelligence is now embedded in how many healthcare students learn. Tools provide rapid explanations, summaries and practice questions, but use does not equal AI literacy, particularly where accuracy, medicines safety and guideline alignment matter.

Objective: To describe current use of generative AI by Physician Associate students and outline a practical approach to teaching critical AI literacy.

Methods: Educational evaluation using three activities: (1) baseline survey of students about use and attitudes, (2) an embedded compare and critique session in applied pharmacology where small groups assessed AI answers against trusted UK sources, including BNF and NICE guidance, followed …

Evaluating The Suitability Of The Berg Balance Scale For Assessing Balance In Diabetes With And Without Prior Covid-19: A Methods-Validation Study, Garima Kaushik Dr, Sheetal Malhan Dr., Apoorva Tiwari Dr, Vishakha Daga Dr

Journal Of Indian Physician Associates

ABSTRACT

Background: Balance impairment in diabetes mellitus is predominantly driven by somatosensory loss secondary to peripheral neuropathy. The Berg Balance Scale (BBS) is widely used to evaluate functional balance, yet it mainly reflects motor performance and may not adequately represent sensory mechanisms. Following COVID-19, additional concerns regarding deconditioning have emerged, but interpretation depends on the measurement tool employed.

Objective: To examine the construct behavior and suitability of the BBS for assessing balance in individuals with diabetes with and without prior COVID-19 infection, and to determine whether the scale reflects known determinants of diabetic imbalance.

Methods: A cross-sectional analysis was conducted …

Exploring Coaching Issues And Feedback Generation During A Virtual International Coaching Exchange, Lori A. Gano-Overway, Ian Hj Cowburn, Liam Mccarthy

Journal of Coach Development

Internship opportunities can provide coaches with the chance to learn through experience and explore their personal theories in practice. However, to effectively develop coaches during internships facilitators of learning need to know more about what student coaches typically perceive and find meaningful to puzzle through to support their learning and developing theory of practice. Grounded in experiential learning theory and the notion of the reflective practitioner, the authors sought to examine how early-career sport coaches identify, frame, and explore practical coaching issues presented through a virtual international coaching exchange. Using a descriptive multiple-case study approach, the authors presented the coaching …

Ischool Student Research Journal, Vol.16, Iss.1

School of Information Student Research Journal

No abstract provided.

Ai And E-Commerce: A Comparative Analysis Of Amazon, Jumia, And Alibaba, Lauren Grace Barden

Honors Projects

Globally there is a great divide between consumer acceptance of artificial intelligence (AI) and the reluctance of the services due to lack of knowledge on its systems. Major global shopping platform, Amazon has adopted the use of AI into their experiences for upholding their pillars of optimization, utilization, and personalization. In the global e-commerce framework,  adoption of AI has been similarly found also in companies like Alibaba (Chinese-based) and Jumia (Kenyan-based). Though these companies have seen customer satisfaction increase with the availability and quality of the service they provide, it is pertinent to note that there are still underlying issues …

Arete - The Balance Of Nature: A Study And Creation Of Greek Tragedy From The Modern World, Grace Margaret Merrill

Honors Theses

This thesis examines the gender roles in ancient Greece through a creative lens. It aims to reach an understanding of the inequalities between men and women. Some of these inequalities involve women’s rights, abortion, and divorce. The main goal of this project is to reveal the discrimination women faced in ancient Greece. Once this is accomplished, I will then use the research to create a play inspired by the traditional Greek tragedy format. This play addresses controversial topics of the time and how individuals would have approached them. While there is ample research into the focus of my topic, there …

Age And Congressional Leader Success: Are They Getting Too Old, Edward N. Drinkwine, Scot Schraufnagel

Honors Capstones

Congressional leaders play a central role in shaping legislative agendas, maintaining party cohesion, and negotiating policy outcomes. Despite the important roles they play, our nation's congressional leaders continue to grow older, and research has rarely examined how age influences their effectiveness in these roles. This study asks whether older congressional leaders are less effective at advancing legislation than their younger counterparts. Using data on leaders serving in the U.S. House and Senate from the 93rd through the 118th Congress, the analysis compares leaders’ ages with their Legislative Effectiveness Score Ratios, controlling for legal experience, state legislative experience, elite education, ideology, …

The Influence Of Financial Literacy On The Financial Behavior Of Students In The Higher Learning Institutions In Tanzania, Lisa John Baltazar, Evelyn Mweta Richard

Business Management Review

This study examines how financial literacy influences financial behavior as measured by spending, saving and investment and borrowing behavior of university students. The study was informed by the theory of planned behavior. Explanatory research design was used to test the research hypothesis. Data was collected through using a structure questionnaire which was administered both physically and online.  446 random selected students across Universities in Tanzania participated in the study, and simple linear regression analysis was used to establish the effect of financial literacy on financial behavior.  It was established that majority of the students are considered financially illiterate. However, the …

Returning To Play: Play-Centered Art Therapy With Parentified Adult Caregivers, Paola Andrea Mendez Carreno

Expressive Therapies Theses

This research investigates the impact of play-centered art therapy on parentified adult caregivers, focusing on how creative interventions utilizing elements of play can support identity development, self-compassion, and relational capacity. The literature indicates that childhood parentification leads to identity loss and burnout, but creative play can foster neuroplasticity and emotional processing by allowing adults to externalize harmful narratives that have been internalized. To explore these concepts, the author conducted four sessions over six weeks with an adult participant at a private outpatient practice in Massachusetts. Play-centered activities included free collaging, puppet-making, and clay modeling, often involving moments of parallel play …

Choosing Your Line: Training Adaptive Ski Instructors How To Facilitate Occupational Participation For Individuals With Complex Communication Needs., Jordan E. Chizmadia, Monique Dawes Otd, Otr/L Cpam

Occupational Therapy Doctorate Capstones

The project will explore communication methods for individuals with complex communication needs (CCN) in adaptive skiing, focusing on alternative communication methods and the development of a Picture Exchange Communication System. A communication training program for ski instructors will be implemented. Findings will advance occupational therapy by highlighting the role of self-directed communication and autonomy in promoting occupational engagement for individuals with CCN.

Limit Of Detection Variations In Polyphenol Mixtures Using Parafac-Feem Spectroscopy, Ken Overway, Brockton Zorn

Honors Projects

Polyphenols are chemical compounds commonly found in food products like olive oil and red wine. Research suggests that their presence in such foods conveys positive cardiovascular and cognitive health benefits. This group of compounds is often difficult to quantify in such samples due to an overlap in the chemical signals and the presence of interferences, such as coloring, found naturally in the food. Use of 3D Fluorescence Excitation Emission Matrix (EEM) measurements combined with pH sensitivity could establish a method in which polyphenols are identified more easily in mixtures. Binary and ternary mixtures of polyphenols were analyzed without the additional …