Digital Commons Network^™

Whole Genome Sequencing Analysis Of Body Mass Index Identifies Novel African Ancestry-Specific Risk Allele, Xinruo Zhang, Jennifer A. Brody, Mariaelisa Graff, Heather M. Highland, Nathalie Chami, Hanfei Xu, Zhe Wang, Kendra R. Ferrier, John Blangero, Joanne E. Curran

School of Medicine Publications

Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P <  5 × 10−9), including two secondary signals. Notably, we identified and replicated a novel low-frequency single nucleotide polymorphism (SNP) in MTMR3 that was common in individuals of African descent. Using a diverse study population, we further identified two novel secondary signals in known BMI loci and pinpointed two likely causal variants in the POC5 and DMD …

Combatting The Adolescent Mental Health Crisis: A Patchwork Of State Legislation Targeting Social Media's Addictive Design, Christine Cromie

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

To Plea Or Not To Plea: Proving Strickland's 'Prejudice Prong' When Counsel Fails To Pursue A Plea Deal, Alexandra Cavanaugh

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Spartan Daily, April 10, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 31

Curricular Changes Proposed For 2025-2027 Morris Catalog, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

Effects Of Metformin Use On Aneurysmal Subarachnoid Hemorrhage Outcomes, Angel Bueno, Andrea Becerril-Gaitan, Collins Mokua, Kristina Ramirez-Garcia, Justin Nguyen, Faris Shaker, Tien Nguyen, Antonio Dono, Spiros Blackburn, Peng Roc Chen, Mark Dannenbaum, H Alex Choi, Arthur L Day, Jacques J Morcos, Ching-Jen Chen

Faculty, Staff and Student Publications

Background: Metformin is widely prescribed and has neuroprotective effects in animals, but its impact on brain injury after aneurysmal subarachnoid hemorrhage (aSAH) in humans is unclear.

Methods: This single-center retrospective review assessed patients with aSAH from 2009 to 2023, categorizing them based on pre-admission metformin use. The primary outcome was delayed cerebral ischemia (DCI), while secondary outcomes included in-hospital mortality, rebleeding, angiographic cerebral vasospasm (CVS), and favorable modified Rankin Scale (mRS) scores at discharge and the 3-month follow-up. Outcomes were analyzed using logistic regression. Sensitivity analysis was performed after excluding patients receiving comfort care.

Results: A total of 900 patients …

April 10, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

April 10, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Fort Hays State University Introduces New Business Retention And Expansion Program, April 10, 2025, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.

Allosteric Targeted Drug Delivery For Enhanced Blood-Brain Barrier Penetration Via Mimicking Transmembrane Domain Interactions, Kaicheng Tang, Zhongjie Tang, Miaomiao Niu, Zuyin Kuang, Weiwei Xue, Xinyu Wang, Xinlong Liu, Yang Yu, Seongdong Jeong, Yifan Ma, Annette Wu, Betty Y S Kim, Wen Jiang, Zhaogang Yang, Chong Li

Faculty, Staff and Student Publications

Current strategies for active targeting in the brain are entirely based on the effective interaction of the ligand with the orthosteric sites of specific receptors on the blood-brain barrier (BBB), which is highly susceptible to various pathophysiological factors and limits the efficacy of drug delivery. Here, we propose an allosteric targeted drug delivery strategy that targets classical BBB transmembrane receptors by designing peptide ligands that specifically bind to their transmembrane domains. This strategy prevents competitive interference from endogenous ligands and antibodies by using the insulin receptor and integrin α

Argentine Diaspora In The United States: Experiences Of Recent Emigrants And Their Ties With The Homeland, Anabela Cibele Villach Vaquer

USF Tampa Graduate Theses and Dissertations

This thesis examines the Argentine diaspora settled in the United States. It analyzes both the experiences of Argentines who have migrated to the United States in the last decade and the transnational ties they develop with the home country as well as the diaspora engagement policies put in place by the Argentine State. The research addresses three key questions: What are the main characteristics of Argentine emigrants who have moved to the United States over the past decade? How do recent Argentine migrants in the United States construct and maintain their transnational ties with their country of origin? Is the …

Time Required To Implement A Computerized Patient Decision Aid For Lupus In Outpatient Visits, Nathan W Carroll, Aizhan Karabukayeva, Larry R Hearld, Diane Kamen, Alfred H J Kim, Sonali Narain, Narender Annapureddy, Zineb Aouhab, Maureen Mcmahon, Vikas Majithia, Cathy Lee Ching, Winn Chatham, Jasvinder A Singh

Faculty, Staff and Students Publications

BACKGROUND: Patient decision aids have the potential to lower decision conflict for patients and to improve patient-physician communication. However, uptake of decision aids has been poor, in part because the time required to incorporate these into clinical practice is not well understood.

OBJECTIVE: To estimate the time required for a rheumatology clinic to implement a validated decision aid for patients with lupus.

METHODS: Using a cohort of eight implementation sites, study investigators identified the activities required to administer a decision aid. Site coordinators embedded within the clinics timed the duration of each activity. To estimate the effect of viewing the …

The Human Brainstem's Red Nucleus Was Upgraded To Support Goal-Directed Action, Samuel R Krimmel, Timothy O Laumann, Roselyne J Chauvin, Tamara Hershey, Jarod L Roland, Joshua S Shimony, Jon T Willie, Scott A Norris, Scott Marek, Andrew N Van, Anxu Wang, Julia Monk, Kristen M Scheidter, Forrest I Whiting, Nadeshka Ramirez-Perez, Athanasia Metoki, Noah J Baden, Benjamin P Kay, Hadas Nahman-Averbuch, Abraham Z Snyder, Marcus E Raichle, Evan M Gordon, Nico U F Dosenbach, Et Al.

2020-Current year OA Pubs

The red nucleus, a large brainstem structure, coordinates limb movement for locomotion in quadrupedal animals. In humans, its pattern of anatomical connectivity differs from that of quadrupeds, suggesting a different purpose. Here, we apply our most advanced resting-state functional connectivity based precision functional mapping in highly sampled individuals (n = 5), resting-state functional connectivity in large group-averaged datasets (combined n ~ 45,000), and task based analysis of reward, motor, and action related contrasts from group-averaged datasets (n > 1000) and meta-analyses (n > 14,000 studies) to precisely examine red nucleus function. Notably, red nucleus functional connectivity with motor-effector networks (somatomotor hand, foot, …

Sociodemographic Differences In Logins And Engagement With The Electronic Health Coach Messaging Feature Of A Mobile App To Support Opioid And Stimulant Use Recovery: Results From A 1-Month Observational Study, Lindsey M Filiatreau, Hannah Szlyk, Alex T Ramsey, Erin Kasson, Xiao Li, Zhuoran Zhang, Patricia Cavazos-Rehg

2020-Current year OA Pubs

BACKGROUND: Mobile health apps can serve as a critical tool in supporting the overall health of uninsured and underinsured individuals and groups who have been historically marginalized by the medical community and may be hesitant to seek health care. However, data on uptake and engagement with specific app features (eg, in-app messaging) are often lacking, limiting our ability to understand nuanced patterns of app use.

OBJECTIVE: This study aims to characterize sociodemographic differences in uptake and engagement with a smartphone app (uMAT-R) to support recovery efforts in a sample of individuals with opioid and stimulant use disorders in the Greater …

Time Required To Implement A Computerized Patient Decision Aid For Lupus In Outpatient Visits, Nathan W Carroll, Aizhan Karabukayeva, Larry R Hearld, Diane Kamen, Alfred H J Kim, Sonali Narain, Narender Annapureddy, Zineb Aouhab, Maureen Mcmahon, Vikas Majithia, Cathy Lee Ching, Winn Chatham, Jasvinder A Singh

2020-Current year OA Pubs

BACKGROUND: Patient decision aids have the potential to lower decision conflict for patients and to improve patient-physician communication. However, uptake of decision aids has been poor, in part because the time required to incorporate these into clinical practice is not well understood.

OBJECTIVE: To estimate the time required for a rheumatology clinic to implement a validated decision aid for patients with lupus.

METHODS: Using a cohort of eight implementation sites, study investigators identified the activities required to administer a decision aid. Site coordinators embedded within the clinics timed the duration of each activity. To estimate the effect of viewing the …

Media Entertainment, Louis Bosshart, Ilaria Macconi

Communication Research Trends

No abstract provided.

Social Media And Sports Betting, Mikey Bishop

Student Research Symposium

No abstract provided.

Through The Lens: Analyzing Apple's 'Shot On Iphone' Social Media Marketing Campaign, Awsumb Hardy

Student Research Symposium

While promoting the iPhone 6s, Apple launched the #ShotOniPhone campaign. It encouraged iPhone users to share photos under the tag #ShotOniPhone.

• Was the campaign a success? Why?
• Did the campaign increase iPhone sales?
• What can we learn from #ShotOniPhone?

The Meme-Ification Of Barbie: How Social Media Turned A Movie Into A Cultural Phenomenon, Jayke Martin

Student Research Symposium

The 2023 Barbie movie became a cultural phenomenon, driven by an innovative marketing campaign that leveraged memes and user- generated content, particularly on TikTok. Users embraced the movie's catchy songs and dance routines, sparking widespread excitement. Strategic brand collaborations with Crocs, Cold Stone Creamery, and NYX, combined with the fashion industry's embrace of pink, amplified the film's impact. Notably, the extensive use of fluorescent pink paint led to a global shortage. The teaser trailer, which parodied 2001: A Space Odyssey and premiered before Avatar: The Way of Water, generated early buzz by challenging audience expectations. The “Barbenheimer” phenomenon emerged when …

The Apple Effect: Unveiling The Power Of Social Media Marketing In Apple's Advertising Mastery, Annie Ploehn

Student Research Symposium

This research dives into the top marketing strategies shown by Apple on their Instagram page. Five main themes have been identified: Creativity, people, nature, emotion, and technique. Through each of these themes we see how Apple fosters a sense of belonging and uses this marketing strategy to encourage continued company growth.

Racism On Social Media, Britton Larsen

Student Research Symposium

For centuries, racism has been an issue in society; however, the emergence of social media has drastically altered the landscape of the vulgarity and encounter of racist content. Social media has become a crucial communication, advocacy, and information battleground. While these platforms have provided a voice through which underprivileged populations become equal in terms of advocating for equality and justice, the same platforms have nurtured the breeding ground for hate messages and discriminatory ideologies. This research will look to explore the relationship between social media and racism, doing so to look at how these social media platforms amplify racist content …

Martha Stewart's Enduring Legacy: A Social Media Case Study, Holly Asay

Student Research Symposium

Martha Stewart gained fame in the 1990s and, at 83 years old, remained culturally relevant on her personal Instagram account. Despite early criticism, she had 2.6M followers and high engagement in 2025.

Tiktok Triumph: Unpacking Duolingo's Marketing Success, Kylee Malcolm

Student Research Symposium

Duolingo, a language learning app, has an infamous social media presence across many platforms. Recently, they took their risky humor to the next level by killing their mascot (don’t worry, there’s a happy ending!)

Their platform on TikTok typically receives more engagement from users and brands, because that is where they first went viral for their ‘threats” against users.

The Digital Dairy Diary: Exploring The Emotional Responses Of Utah Social Media Users To Dairy Content, Patryce Eldredge

Student Research Symposium

Social media is powerful in distributing information and helping society to develop perceptions and sentiments. Social media can be a useful tool in community agriculture. However, without an understanding of the emotions held by social media users concerning the dairy content on social media, ag educators can’t effectively use social media as an educational tool.

Sizzling Success: The Impact Of Wendy's Twitter Roast Campaign, Bryan Mortensen

Student Research Symposium

Introduction

The Wendy’s Roast Me social media campaign created massive engagement, increased brand awareness, and improved brand reception. The reason that I choose to analyze this campaign is because I wanted to read more Wendy’s roasts.

The social media platform that I have chosen to analyze is TikTok, however I did do some research on Twitter as well in order to be able to compare their performance.

Today, I am aim to answer three questions:

• How did TikTok compare to Twitter?
• What made this campaign so successful?
• Can we apply anything from this campaign to others

Child Protective Services Accountability And Reform: The Role Of Judicial Oversight, Caseworker Training, And Systemic Failures In Protecting Vulnerable Children, Amiah Kuykendall

Student Research Symposium

Introduction

What is the purpose of this project?

▪ Investigate systemic failures

o Research question:

▪ How does judicial oversight influence CPS caseworker accountability in child abuse cases, and what legal measures can be taken to ensure policy enforcement?

Frequency Of Fruit And Vegetable Consumption Among Women Diagnosed With Gestational Diabetes, Hailey Koster

Student Research Symposium

• Consuming fruits and vegetables has been associated with a reduced risk of gestational diabetes and improved pregnancy outcomes. ¹

• However, the majority do not meet the recommendation of five servings per day or 400 g per day according to the World Health Organization.²

Unveiling The Success: Analyzing The Social Media Marketing Of Hailey Bieber's Rhode Skin 'Lip Shape' Campaign, Kensington Clements

Student Research Symposium

For this project, I’m looking at Hailey Bieber’s Rhode Skin Lip Shape campaign and how it was marketed on social media. I decided to focus on Instagram because Hailey is the most active there.

Social Media Health Campaign: Combating Rsv In Infants Through Education And Advocacy, Kyndie Jorgensen

Student Research Symposium

Education and awareness surrounding RSV has made people more aware of how it is spread and what it is. Less communication campaign work has been done to help people understand the symptoms of RSV in healthy adults who may pass it to infants and to support parents in advocating for their child's safety.

Xbox's Social Media Ads: Themes, Reactions, And Engagement With Game Pass Promotions, Talmage Robertson

Student Research Symposium

Subscription based entertainment has broken into the video game industry. Xbox Game Pass has set the trend for the future of subscriptions in gaming, but how does the marketing of Game Pass rope players to subscribe?