A Strategic Audit: Eli Lilly & Company, Natalie Karrels, Ethan Heinemann, Jonathan Patton, Meg Williams

Honors Program: Senior Projects (Public)

This strategic audit assesses the external and internal forces impacting Eli Lilly & Company’s strategic decision-making strategies. All information has been gathered from industry reports and company reports, including reports for investors, analyst calls, financial statements, and news reports. The report highlights the quantitative, qualitative, performance, strategy, and leadership decisions that have allowed Eli Lilly & Company to succeed for the past 150 years.

The Role Of Ai In Enhancing Teamwork, Resilience And Decision-Making: Review Of Recent Developments, Satyadhar Joshi

Harrisburg University Other Works

This paper explores the transformative impact of artificial intelligence (AI) on organizational teamwork, decision-making, and resilience. This paper furthur reviews recent literature on the integration of Artificial Intelligence (AI) in various organizational functions, focusing on its impact on innovation management, leadership paradigms, and organizational resilience. We provide groundwork required to enhance frameworks that can integrate cognitive scaffolding with antifragile team dynamics, employing behavioral economics and neurocognitive principles. We introduce methodologies for enhancing team resilience through adaptive AI systems, cross-training interventions, and pre-mortem simulation techniques. The framework addresses key challenges in confirmation bias mitigation, cultural dimension alignment, and vigilance decrement prevention. …

Wired For Degradation: How Post-Translational Control Of Inducible Camp Early Repressor Protein Influences Melanoma Fate, Melissa Rose Spigelman

Theses, Dissertations and Culminating Projects

Melanoma is a highly aggressive form of skin cancer frequently driven by mutations in the BRAF gene, particularly the BRAFⱽ⁶⁰⁰ᴱ variant, which leads to sustained activation of the MAPK signaling cascade. Recent studies implicate the cyclic AMP (cAMP) signaling axis in melanoma progression and therapeutic resistance, highlighting the role of the Inducible cAMP Early Repressor (ICER), a transcriptional antagonist of CREB and CREM. ICER is downregulated during melanomagenesis and subject to post-translational regulation via phosphorylation and ubiquitin-mediated degradation. To investigate ICER’s functional relevance in vivo, e utilized a zebrafish melanoma model harboring brafⱽ⁶⁰⁰ᴱ, tp53−/−, and mitf−/−mutations, in which mitf expression …

Considerations And Techniques For Producing Urban Tree Canopy Maps Using Freely Available And Accessible Methods, Hugh Reed Ellerman

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Urban forests are valued as green infrastructure for the variety of benefits they provide across ecological, social, public health, and economic domains. To understand the distribution of trees, maps are required. Many methods of mapping tree cover use expensive and data-intensive datasets such as hyperspectral and LiDAR imagery, making these methods inaccessible to municipal forest managers. Variations in the modelling approaches of existing, freely available methods are not addressed in sufficient enough detail to understand the trade-offs implicit in these variations. Further, characteristics of urban tree canopy mapping (high spatial resolution imagery, heterogeneous urban environments, the importance of the tree …

Gonadotropin-Releasing Hormone Ii And Its Receptor: Novel Regulators Of Semen Quality And Follicular Function In Swine, Caitlin Elizabeth Ross

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Pigs are the only mammalian livestock species encoding functional proteins for the second form of gonadotropin-releasing hormone (GnRH-II) and its receptor (GnRHR-II). In the first study, GnRHR-II localized to developing germ cells and the connecting piece of ejaculated spermatozoa. Concurrently, GnRH-II was most abundantly produced in the testis compared with other reproductive tract organs and was present within seminal plasma. Moreover, treatment of extended semen with GnRHR-II analogues altered sperm motility, morphology, and kinematics. For remaining studies, we utilized a swine line with ubiquitous knockdown of GnRHR-II (GnRHR-II KD) developed in our laboratory. The second study demonstrated that circulating GnRH-II …

Of Headlamps And Marbles: A Motivated Perceptual Approach To The Dynamic And Dialectic Nature Of Fairness, Michael Ramsay Bashshur, Laurie J. Barclay, Marion Fortin

Research Collection Lee Kong Chian School Of Business

How do people perceive fairness? Recently, fairness scholars have raised important theoretical questions related to what information is used in fairness perceptions, why this information is emphasized, and how fairness perceptions can change over time. Integrating the Brunswikian lens approach with a motivated cognition perspective, we develop the Motivated Perceptual Approach (MPA) to highlight how people can be motivated to selectively perceive and weight cues to form fairness perceptions that align with their motives. However, these motives can change over time and through interaction with motivated others. By illuminating the dynamic and dialectic processes underlying fairness perceptions, the MPA sheds …

Group Therapy For Autistic Adults Over Telehealth: Challenges And Guidelines For Clinicians, Antonio F Pagán, Stephen Armstrong, Amy Izuno-Garcia, Killian R Hughes, Katherine A Loveland

Faculty, Staff and Student Publications

Autism spectrum disorder (ASD) is associated with challenges in areas such as social skills and behavior, with 1 in 36 children diagnosed in the U.S. Annually, over 100,000 adolescents with ASD transition to adulthood, often facing a "service cliff" where support diminishes. Group therapy can help autistic adults by enhancing social skills, executive functioning, and emotional regulation while fostering belonging and reducing isolation. Telehealth-based group therapy offers additional benefits, particularly for those with social anxiety, geographic barriers, or limited transportation. While telehealth is effective for autistic adults, practical guidelines for virtual group therapy are lacking. This article provides recommendations for …

Amniotic Fluid Extracellular Vesicle And Cell-Free Rna Profiling Reveals Fetal Adaptations In Twin-Twin Transfusion Syndrome, Jacqueline G Parchem, Huihui Fan, Lovepreet K Mann, Kadeshia M Campbell, Sujuan Yang, Wencai Ma, Jong H Won, Jing Wang, Ramesha Papanna, Raghu Kalluri

Faculty, Staff and Student Publications

No abstract provided.

Data-Driven Audits: Audit Analytic Platforms And General Ledger Analytic Tools, Daniel E. O'Leary, Vernon J. Richardson, Marcia Weidenmier Watson

Accounting Faculty Publications and Presentations

The future of auditing is a data-driven audit, which extracts and analyzes digital data stored in client accounting systems. To help conduct data-driven audits, audit firms are developing audit analytic platforms (AAPs). This paper focuses on one key application tool of AAPs that analyzes the entire population of general ledger transactions. These general ledger analytics tools (GLATs) use assessment routines to assign a risk score to each transaction, helping guide the auditor’s planning, risk assessment, and selection of high-risk transactions for substantive procedures. GLATs help support audit quality and provide valuable new insights about client operations. We discuss the analytics …

Emergent Models Of Place-Based Philanthropy: A Review Of Six Foundations’ Initiatives, Douglas Easterling

The Foundation Review

Traditional approaches to place-based philanthropy, including comprehensive community initiatives (CCIs), are characterized by four design features: 1) a centralized stakeholder group that serves as the primary nexus for the foundation’s engagement; 2) an extensive planning process on the front end; 3) the planning group’s initial strategy serves as the basis for the foundation’s investments throughout the initiative; and 4) foundation staff play a largely transactional role in reviewing proposals, awarding grants and monitoring progress. This linear, structured approach to community change has had only limited success over 30 years of foundation practice.

In response, a growing number of foundations have …

Strengthening Evaluation Contracting Partnerships: Fostering Stronger Relationships Between Funders And Small, Proximate Evaluation Firms, Hippolyt Pul, Carlisle Levine

The Foundation Review

Foundations often support initiatives in multiple countries and cultures, including within the United States, with limited access to or familiarity with the people and local contexts in which activities occur. To gain a deep and nuanced understanding of their investments’ relevance, effectiveness, and sustainability, foundations are often eager to partner with evaluators close to the contexts and people who participate in and are most affected by their investments.

Yet, foundations’ procurement and contracting systems may not be built for these partnerships. Through the Strengthening Evaluation Contracting Partnerships Initiative, we are addressing this challenge by helping foundations, small and proximate evaluation …

User Acceptance Of Shared Autonomous Vehicles, Haotian Su

All Dissertations

A dissertation is proposed to explore user acceptance of shared autonomous vehicles (SAVs). SAVs are facing limited user acceptance. To systematically tackle the user acceptance barriers of SAVs, the main problem can be disintegrated into two sub-problems of user acceptance of autonomous vehicles (AVs) and ridesharing. The comfort of the ride experience in AVs is a determinant of user acceptance. Understanding the influential factors and developing methodologies to quantify human comfort in AVs are essential to facilitating future research to improve human comfort in AVs. The current pooled rideshare (PR) service closely resembles the anticipated future of SAVs. Understanding why …

Grid Forming Inverters For Microgrid Operation Enhancement, Jan Westman

All Dissertations

Modern electric power systems are confronted with several major challenges including the increasing frequency and severity of weather events, aging infrastructure, high material costs, cyber-attacks, and substantial delays in global supply chains. Microgrids provide a solution to these challenges by insulating customers from the power outages occurring in their local distribution system. A microgrid is a small independent power system with its own power generation and energy storage resources that can supply customers’ electricity needs. When an outage occurs, a circuit breaker will disconnect the microgrid from the distribution system. Successful operation of the microgrid requires one or more devices …

The Effects Of Cigarette Smoke Extract On Osteoarthritis In A Primary Joint Tissue Explant Model, Emily Sawvell

All Dissertations

Osteoarthritis (OA) is the most common degenerative joint disease in the world with an economic burden of nearly $140 billion annually. Factors identified to increase the risk of developing OA include age, obesity, sex, race, genetics, and previous joint injury. However, one risk factor that has been scarcely studied in OA etiology is cigarette smoking. While some studies have reported smoking to protect against OA, increasing evidence suggests that cigarette smoking results in more severe and painful OA, increases the rate of developing OA, and reduces the efficacy of pain medications and arthritis-targeting therapies. Despite this, the impact of cigarette …

Integrating Applied History And Artificial Intelligence (Ai) Into City Planning Practice, Russell H. Stall

All Dissertations

History matters. History provides a vital foundation for shaping present decisions and future planning. By understanding a city’s past, cities can make more thoughtful, informed choices to guide development and policy with greater intention and impact.

Greenville, South Carolina, is a unique city planning case study and learning laboratory. Greenville’s Downtown revitalization since the 1980s demonstrates how historical insights can be integrated into contemporary policymaking to create vibrant, human-centered, and citizen-focused urban environments. Greenville’s evolution from a deserted, forgotten Main Street to one of the world’s most livable cities is an example of community development worthy of emulation from other …

The Genomic Landscape And Prognostic Impact Of Kras, Stk11, And Smarca4 Mutations And Co-Mutations On Survival Outcomes In Non-Small Cell Lung Cancer, Peter Manolakos

All Dissertations

Non-small lung cancer (NSCLC) accounts for 85% of lung cancer cases, and Kirsten rat sarcoma viral oncogene homolog (KRAS), Serine/Threonine Kinase 11 (STK11), and SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMARCA4) mutations and co-mutations have been increasingly recognized for their potential prognostic significance. However, clear knowledge gaps remain regarding which treatments should be selected for patients who present clinically with KRAS/STK11 or KRAS/SMARCA4 co-mutations, as outlined in Chapter 1. Despite significant clinical development advancements in immunotherapy and targeted therapy, a deeper understanding of the influence of these genomic …

Exploring The Pedagogical Impact Of Software Development Live Streams: Informal Learning Opportunities For Software And Game Developers, Ella Kokinda

All Dissertations

Live streaming is an increasingly popular medium for throwing back the curtain on software development where streamers and viewers share their knowledge and experiences. Popular platforms like Twitch and YouTube enable developers to stream live coding sessions where people around the world can engage in real-time collaboration, feedback, knowledge sharing, and skill development. This work investigates the pedagogical implications and learning opportunities present in software and game development live streaming while focusing on the role of streaming as a learning environment and collaborative community. We begin by exploring summer camps as an informal learning opportunity for STEM education, highlighting the …

Stromal Cells In The Small Intestine: Physiology, Localization, Function, And Alterations Induced By Chronic Arsenic Exposure, Scott Ventrello

All Dissertations

Arsenic is a prevalent toxicant found to affect around 94 to 240 million individuals in over fifty countries who are exposed to levels above the EPA and WHO standard of 10 ppb. As one of WHO’s top ten chemicals of public health concern, it is linked to several chronic diseases including diabetes, obesity, cancers, and inflammatory bowel diseases. Arsenic increases inflammation and disrupts the intestinal barrier in the small intestine and colon. Further, previous studies found that arsenic decreased secretory cell lineage and stromal cell gene expression markers in the small intestine. Thus, our goal was to investigate arsenic’s effect …

Preparing Preservice Teachers To Support Culturally And Linguistically Diverse Students Through The Implementation Of A High Leverage Practice, Mya Kelley

All Dissertations

The student population of United States (U.S.) schools is becoming more culturally and linguistically diverse. Similarly, students identifying as culturally and linguistically diverse students represent approximately 54% of students served under the Individuals with Disabilities Act (U.S. Department of Education, 2023). Despite increased ethnic diversity among students, the teacher workforce remains relatively homogenous, with most teachers identifying as White. Consequently, many new teachers feel ill-equipped to implement effective, evidence-based instructional practices to support culturally and linguistically diverse students. To prepare preservice teachers to meet culturally and linguistically diverse students' unique needs, teacher preparation programs must embed culturally relevant pedagogy and …

Serious Leisure, Passion, And Burnout, Carson Matsick

All Dissertations

This study examined the relationships between aspects of serious leisure, dualistic passion, and burnout in the MBI-GS and BM. Serious leisure has been shown to improve leisure and general life outcomes, but little research considers how harmonious or obsessive leisure engagement affects these outcomes or has extended serious leisure benefits to the workplace. Overall, the study hypothesized that leisure seriousness, harmonious passion, and satisfaction with time spent in serious leisure will negatively correlate with burnout, and obsessive passion will degrade the benefits derived from serious leisure. 240 participants completed Gould's Serious Leisure Inventory, the Passion Scale, the Maslach Burnout Inventory …

Am I Woke Enough To Serve In Healthcare: A Secondary Analysis Of Pre-Health Students’ Personal And Professional Growth By Engaging In Cultural Competency Assessments, Harolynn Williams

All Dissertations

Healthcare providers must be equipped to serve an increasingly diverse population, yet cultural competence remains underemphasized in undergraduate pre-health education. This study explored how embedded cultural competency training influences undergraduate pre-health students’ perceptions of personal and professional growth. Using a qualitative descriptive design, the research incorporated intercultural assessments, the Intercultural Development Inventory (IDI), and the Global Competence Certificate (GCC), along with qualitative reflections from students enrolled in three versions of a cultural competence course: a year-long course, a semester-long course, and a short-term study abroad immersion six-week course. Findings revealed that students demonstrated measurable growth in cultural awareness, knowledge, communication, …

Real-Time Active Thermal Management And Degradation Forecasting Of Power Electronics Building Blocks In All-Electric Ships, Ali Moghassemi

All Dissertations

With advancements in semiconductor technology, power electronic devices play a critical role in modern power systems, enabling efficient energy conversion in applications such as renewable energy integration, electric vehicle drives, industrial automation, and Navy ship power systems. However, the increasing use of power converters presents challenges such as harmonic reduction, cost optimization, reliability improvement, and thermal management, especially in weight- and space-constrained environments like wind turbines and shipboard systems. High-frequency switching, while reducing passive filter size, increases thermal stress on semiconductor devices, impacting efficiency and longevity. Active thermal control, which regulates junction temperature through power loss management, and degradation forecasting, …

Live-Streaming E-Commerce: The Role Of Firms And Influencers In Driving Sales, Jingyun Hu

All Dissertations

Livestreaming is a transformative technology that removes the limitations of time and lo- cation, enabling real-time interaction between hosts and audiences. When combined with online shopping, it creates livestreaming e-commerce, a fast-growing marketing channel where influencers promote products live and engage directly with consumers.

My doctoral dissertation explores how firms and influencers collaborate effectively in this emerging retail space. Livestreaming e-commerce offers new opportunities for reaching consumers, but also raises questions about how to manage partnerships and present products in a dynamic, real-time setting. Specifically, I investigate how firms should choose and switch influencers over time, and how influencers can …

An Analysis Of Principal Influence On Teacher Retention In A Rural School District: An Exploratory Qualitative Study, Stephanie Davis

All Dissertations

Research shows that nearly one-third of novice teachers leave the profession before their third year, and almost half leave by their fifth year, with turnover rates remaining steady. Teacher job satisfaction and dissatisfaction are influenced by various factors, with administrative support playing a key role. This exploratory qualitative study examined how principals' leadership behaviors affect teacher retention. Through surveys and interviews with principals and teacher representatives from nine schools, the study found that positive principal leadership significantly influences teachers' decisions to stay in their schools. Principals actively engage in behaviors, both direct and indirect, that help retain teachers. The study …

Bridging The Gap In Rural Education: Exploring Solutions For Enhanced College And Career Preparedness Among Secondary School Students, Patricia Moultrie-Goldsmith

All Dissertations

This study investigates how to improve college and career readiness (CCR) among high school students in rural areas. The study focuses on creating effective strategies that cater specifically to the unique needs of rural students. Using a blend of both quantitative and qualitative research methods, the study examines the effectiveness of specific interventions designed to raise students' readiness for college and careers.

The interventions tested include teaching methods and increased engagement with students. These were developed to tackle the common challenges that hinder educational outcomes in rural settings, such as limited access to advanced courses and extracurricular activities.

Findings from …

Leadership Matters: The Impact Of Transformational Leadership And Mattering On Job Attitudes And Perceived Performance, Chelsea E. Robbins

All Dissertations

Mattering refers to the sense that one is significant and valued by others, which has been linked by a small but growing body of research to key work-related outcomes, including job satisfaction, organizational commitment, and job performance. This study examines mattering among Basic Science Medical Educators (BSME), a group potentially vulnerable to low workplace mattering due to limited leadership support and isolation from communities of practice. Consideration for follower well-being is important across many leadership theories, and transformational leadership behaviors overlap highly with behaviors thought to increase mattering. Survey responses from BSME and a general workforce sample were analyzed to …

Integrating Artificial Intelligence For Transportation Cyber-Physical Systems: From Detection To Cyber Resilience, Reek Majumder

All Dissertations

This dissertation investigates different methods for methane detection using unmanned aerial vehicles (UAVs). The author addresses the fundamental problem of methane emissions, a potent greenhouse gas responsible for global warming. The first part of the dissertation aims to create a cost-effective system for real-time methane detection and intensity prediction using ensemble learning models trained on meteorological parameters. The ensemble learning-based classification models show a high accuracy for methane detection.

The second part of the dissertation investigates cyberattack detection for UAVs using a graph-based intrusion detection system (IDS) for controller area networks (CAN). This lightweight, protocol-independent IDS uses graph-based machine learning …

User Acceptance Of Shared Autonomous Vehicles, Haotian Su

All Dissertations

A dissertation is proposed to explore user acceptance of shared autonomous vehicles (SAVs). SAVs are facing limited user acceptance. To systematically tackle the user acceptance barriers of SAVs, the main problem can be disintegrated into two sub-problems of user acceptance of autonomous vehicles (AVs) and ridesharing. The comfort of the ride experience in AVs is a determinant of user acceptance. Understanding the influential factors and developing methodologies to quantify human comfort in AVs are essential to facilitating future research to improve human comfort in AVs. The current pooled rideshare (PR) service closely resembles the anticipated future of SAVs. Understanding why …

Strengthening The Bonds Between Us: An Empirical Investigation Of Morale In Human-Ai Teams And The Socially Supportive Ai Teammates Who Empower It, Rohit Mallick

All Dissertations

This dissertation investigates how artificial intelligence (AI) can be designed to improve the collective emotion within a team. A team's collective emotion, or morale, describes how motivated, optimistic, and enthusiastic the group is in accomplishing its goals. We conducted four studies that compared different social support strategies that AI teammates can provide to the team. Study 1A found that AI teammates who communicate with emotions can better motivate human team members and promote awareness of team dynamics and environmental changes. Study 1B found that human teammates become more motivated and happier when their AI teammates express joy and are close …

An Investigation Of Design Processes And Their Effects On Accessibility In Narrative Themed Environments, Arielle Spencer

All Dissertations

Accessibility matters, and not merely in meeting minimum codes or limited to basic necessities. Access and inclusion matter still more in places of recreation and leisure which have too often been overlooked or considered low priority, however it is precisely these places that merit special attention. Narrative Themed Environments occupy a unique position relative to the general built environment, often acting as utopic ‘other-spaces’ for enjoyment, freedom, and escape. However, for guests with disabilities, current themed experiences can often lack true inclusivity and instead create inequality, segregation, diminished experiences, and feelings of isolation and exclusion. The peculiar idiosyncratic design process …