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Transgressive Body, Open Mind, And Perceptive Spirit For Nurturing Soul: A Reflection On Teaching To Transgress, Akie F. Wenk Aug 2025

Transgressive Body, Open Mind, And Perceptive Spirit For Nurturing Soul: A Reflection On Teaching To Transgress, Akie F. Wenk

Journal of Communication Pedagogy

In this reflection essay, I discuss my journey into the liberatory pedagogy bell hooks champions. As a foreign-born Japanese woman, who speaks English as her second language, being in the classroom itself can be seen as a transgressive act. Positioning myself as an educator who strives to creates an environment that is liberatory for me and my students, I discuss my specific experience and relationship to theories surrounding critical feminist pedagogy and how I practice these theories in my own classroom.

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The Lived Experience Of The Orgasm Gap In U.S. Cisgender Women In Heterosexual Relationships, Alina Beverly Vergara-Hegi Aug 2025

The Lived Experience Of The Orgasm Gap In U.S. Cisgender Women In Heterosexual Relationships, Alina Beverly Vergara-Hegi

Walden Dissertations and Doctoral Studies

Women are not orgasming as often as men in heterosexual sexual encounters. Research has confirmed that sociocultural influences, gender differences, sexual perceptions, sexual miseducation, and relationship dynamics contribute to women’s negative sexual experiences. What has been missing is a better understanding of the experience of the orgasm gap and the role of gender ideology in women’s sexual experiences. This study explored the lived experience of the orgasm gap and gender ideology in nine cisgender women in long-term heterosexual relationships. Critical feminist theory was used as the lens to explore the meaning of sexual inequities in intimate long-term relationships. Using interpretative …

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The Relationship Between Federal Employees' Viewpoints On Intrinsic Meaningful Work In The Extrinsic Work Unit Environment And Job Satisfaction., Sandra Kunz Aug 2025

The Relationship Between Federal Employees' Viewpoints On Intrinsic Meaningful Work In The Extrinsic Work Unit Environment And Job Satisfaction., Sandra Kunz

Walden Dissertations and Doctoral Studies

Managers are concerned with low job satisfaction since it is a prediction of decreased productivity and increased turnover. Framed within the two-factor theory, the purpose of this quantitative correlational post-facto study was to examine the relationship between intrinsic meaningful work in the extrinsic work unit environment and job satisfaction. The participants were 1,378 U.S. federal employees from the Office of Personnel Management who completed the Federal Employee Viewpoint Survey in 2023. The results of the multiple linear regression were significant, F(2, 1375) = 900.817, p < .001, R² = .567. Recommendations for managers include aligning employees with positions that reflect their skills and interests, enhancing communication regarding the significance of individual contributions, seeking out employee feedback, and resolving any work environment challenges to foster greater job satisfaction. The implications for positive social change include the possibility for managers to advance effective leadership and communication, thereby enhancing the work environment for employees and the quality of service to customers.

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Anonymous Donor Honors Parents With Literacy Gift, Tina H. Hahn Aug 2025

Anonymous Donor Honors Parents With Literacy Gift, Tina H. Hahn

University of Mississippi News

OXFORD, Miss. – An anonymous donor said his many lifelong connections with the University of Mississippi inspired him to make a $1 million gift to advance children's literacy.

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Investigation Of The Boulder Porphyry Prospect Jefferson County, Montana, Everett Labudda Aug 2025

Investigation Of The Boulder Porphyry Prospect Jefferson County, Montana, Everett Labudda

Graduate Theses & Non-Theses

With increasing demand for domestic sources of base, precious, and critical metals, previously underexplored mineral systems in the United States are gaining attention. The Boulder Porphyry project (BPP), located 15 miles north of Butte, in Jefferson County, Montana, represents a concealed and underexplored copper-molybdenum porphyry system that shares a similar geologic setting with the world-class mining district in Butte, Montana. This thesis applies a combination of traditional and modern exploration techniques to better understand the nature of hydrothermal mineralization at the BPP. Short-wave infrared (SWIR) analysis of drill core, coupled with bulk rock geochemistry, is used to characterize hydrothermal alteration …

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Adaptive Leadership And Employee Retention During Disruptive Times In Real Estate, Susej Koral Corrales Bethancourt Aug 2025

Adaptive Leadership And Employee Retention During Disruptive Times In Real Estate, Susej Koral Corrales Bethancourt

Walden Dissertations and Doctoral Studies

Some real estate agency owners in Panama lack adaptive leadership strategies to retain employees during market disruptions. The real estate industry and agency owners are especially vulnerable to financial fluctuations and market volatility, which can lead to increased employee turnover and decreased organizational performance. This qualitative pragmatic inquiry explored the adaptive leadership strategies used by Panamanian real estate agency owners to retain employees during disruptive periods. Guided by Heifetz and Linsky’s adaptive leadership theory, the project addressed the central research problem through semistructured interviews with six real estate owners and managers with at least 4 years of leadership experience. Participants …

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Staff Education Program For Fall Prevention, Priya Sebastian Vadakkan Aug 2025

Staff Education Program For Fall Prevention, Priya Sebastian Vadakkan

Walden Dissertations and Doctoral Studies

Falls are the most common adverse events leading to increased injury, length of hospital stay, and costs among hospitalized patients. I developed a staff education project to address the identified practice problem of increased fall rates on the cardiac floor of the project site. The practice-focused question guiding this Doctor of Nursing Practice (DNP) project was whether a comprehensive staff education program on evidence-based fall prevention strategies could improve the nurses’ knowledge when compared to standard fall prevention practices. The purpose of this DNP project was to provide staff education to increase nurses’ knowledge about the early identification of fall …

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Enhancing Novice Nurse Educator Success: A Comprehensive Orientation And Mentorship Program, Emily R. Luther Aug 2025

Enhancing Novice Nurse Educator Success: A Comprehensive Orientation And Mentorship Program, Emily R. Luther

Doctor of Nursing Practice Projects

Nursing education programs face challenges from faculty shortages, high turnover, and limited onboarding support for new educators. This Doctor of Nursing Practice (DNP) project assessed the effectiveness of a structured orientation and mentorship program aimed at improving competency, job satisfaction, and retention among novice nurse educators within a mid-sized nursing program in the southeastern United States. The project addressed gaps in existing onboarding processes that left new faculty unprepared, which contributed to dissatisfaction and attrition. A mixed-methods pre- and post-intervention design was utilized. Quantitative data were gathered through the Self-Assessment of Nurse Educator Competencies (SANE-C), the Minnesota Satisfaction Questionnaire (MSQ), …

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The Challenges Faced By Postrelease Offenders In Rural Mississippi, Whitney Starks Aug 2025

The Challenges Faced By Postrelease Offenders In Rural Mississippi, Whitney Starks

Walden Dissertations and Doctoral Studies

Reintegration after incarceration has long been a subject of scholarly inquiry, particularly regarding barriers to employment, housing, and mental health services. However, limited research addresses the reintegration experiences of postrelease offenders in rural regions, where access to essential resources is often restricted. This qualitative single case study is an exploration of the challenges and service needs of formerly incarcerated individuals living in rural Mississippi. Using purposive and snowball sampling, six participants were selected based on residency in rural counties, a nonviolent criminal history, and at least one year of successful community reentry. The conceptual framework was guided by the assess, …

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Reducing The School-To-Prison Pipeline Through Restorative Practices And Culturally Responsive Teaching, William Clifford Banks Iii Aug 2025

Reducing The School-To-Prison Pipeline Through Restorative Practices And Culturally Responsive Teaching, William Clifford Banks Iii

Masters Projects

Research has shown there is a growing trend that students of color end up becoming incarcerated due to the school-to-prison pipeline. Students of color are being targeted by exclusionary policies at a higher rate than their white counterparts. School districts must reevaluate their discipline measures and adopt new policies that work to build positive relationships and communities within them. This project provides the groundwork for implementing restorative practices and culturally responsive teaching in schools, with the hope of building stronger community ties and reducing exclusionary discipline policies. The project provides research that supports the implementation of restorative practices and culturally …

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Effectiveness Of Cognitive-Behavioral Therapy For Generalized-Anxiety Disorders In Adolescents: A Systematic Review Using Pico Framework, Rajwa D. Suryanto, Prodio E. Gaharani, Salam Salsabila, Calista Aziz, Fitri A. Khaerani, Salsabila Athaya, Lulu A. Setyowati, Elisya Kartadikaria, Muhammad I. Djamaluddin, Renata B. Soewahju, Dian A. Pitaloka Aug 2025

Effectiveness Of Cognitive-Behavioral Therapy For Generalized-Anxiety Disorders In Adolescents: A Systematic Review Using Pico Framework, Rajwa D. Suryanto, Prodio E. Gaharani, Salam Salsabila, Calista Aziz, Fitri A. Khaerani, Salsabila Athaya, Lulu A. Setyowati, Elisya Kartadikaria, Muhammad I. Djamaluddin, Renata B. Soewahju, Dian A. Pitaloka

Pharmacology and Clinical Pharmacy Research

A number of teenagers experience various levels of mental disorders, ranging from mild stress to Generalized Anxiety Disorder (GAD). According to the World Health Organization (WHO), approximately 264 million people suffer from anxiety disorders, including GAD, and this condition is a significant leading cause of suicide incidents, ranking sixth among serious mental health issues. From a societal perspective, Cognitive Behavioral Therapy (CBT) has the advantage of cost-effectiveness by minimizing the use of medications and enhancing productivity in education for adolescents receiving CBT. This study aims to conduct a systematic review of the existing literature on GAD in adolescents, using the …

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Effectiveness Of Pharmacist-Led Intervention For Hepatitis C Patients - A Systematic Review, Geraldo Surya, Angelica Angelica, Zerra Rizki Amalia, Diflaa Kayla Nisrina, Widya Norma Insani Aug 2025

Effectiveness Of Pharmacist-Led Intervention For Hepatitis C Patients - A Systematic Review, Geraldo Surya, Angelica Angelica, Zerra Rizki Amalia, Diflaa Kayla Nisrina, Widya Norma Insani

Pharmacology and Clinical Pharmacy Research

Pharmacist-led interventions, encompassing patient education, adherence monitoring, and personalized care, have emerged as a critical strategy to optimize treatment outcomes in Hepatitis C (HCV) management, particularly in improving Sustained Virologic Response (SVR) and mitigating drug-related challenges. This review evaluates evidence from randomized controlled trials (RCTs), cohort studies, and retrospective analyses to assess the impact of pharmacist-led interventions on key HCV treatment outcomes, including SVR, medication adherence, and management of adverse drug reactions (ADRs) and drug-drug interactions (DDIs). A systematic search was conducted on PubMed database for studies published between January 2000 and December 2024 following PRISMA guidelines. The search strategy …

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Identification Of Drug Related Problems (Drps) Based On Drug And Dosage Selection In Type 2 Diabetes Mellitus Patients, Dhani Wijaya, Fathia F. Rahmadanita, Ria R. Atmaja, Sadli Syarifuddin, Roihatul Mutiah, Atiqoh N. Habibah, Fika S. Nafisah Aug 2025

Identification Of Drug Related Problems (Drps) Based On Drug And Dosage Selection In Type 2 Diabetes Mellitus Patients, Dhani Wijaya, Fathia F. Rahmadanita, Ria R. Atmaja, Sadli Syarifuddin, Roihatul Mutiah, Atiqoh N. Habibah, Fika S. Nafisah

Pharmacology and Clinical Pharmacy Research

Pharmacological therapy for type 2 diabetes mellitus involves more than one type of drug, this increases the potential for Drug Associated Problems (DRPs) in terms of selecting the type and dose of the drug. This study aimed to determine the treatment profile and identify the occurrence of DRPs based on drug selection and dosage in patients with type 2 diabetes mellitus. This descriptive observational study was conducted in October 2022 in the medical record room of one general hospital in Batu, East Java. The study sample was obtained by total sampling using 36 medical records of inpatients with type 2 …

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Development Of A Clinical Practice Guideline For Trauma-Informed Care In Interprofessional Health Care Settings, Ngwi Rita Etiendem Aug 2025

Development Of A Clinical Practice Guideline For Trauma-Informed Care In Interprofessional Health Care Settings, Ngwi Rita Etiendem

Walden Dissertations and Doctoral Studies

Developing a standardized Clinical Practice Guideline for Trauma Informed Care was a central objective of this Doctor of Nursing project. This project followed an evidence-based, collaborative, and structured methodology that prioritized interdisciplinary input, organizational alignment, and rigorous appraisal using the AGREE II instrument.

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Beyond The Individual: Community Socioecological Correlates Of Mass Shootings In A Cross-Sectional Analysis, Barbara (Basia) E. Lopez Aug 2025

Beyond The Individual: Community Socioecological Correlates Of Mass Shootings In A Cross-Sectional Analysis, Barbara (Basia) E. Lopez

Walden Dissertations and Doctoral Studies

Mass shootings represent an urgent and persistent threat to public safety in the United States, yet most research has focused on individual-level characteristics, leaving community-level socioecological conditions comparatively underexamined. This study addressed this gap in knowledge through an examination of the statistical correlations between community-level characteristics and mass shooting incidence using Ostrom’s social-ecological systems theory as a guiding framework. A cross-sectional quantitative design was employed using secondary data from The Violence Project, the U.S. Census Bureau, Neighborhood Atlas National Data Archive, and publicly available law enforcement and policy records. Multiple regression analysis was performed to test both main and interaction …

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Relationship Between Doctor Communication And Patient Satisfaction In Inpatient Units In California, Sandra Viehoever Aug 2025

Relationship Between Doctor Communication And Patient Satisfaction In Inpatient Units In California, Sandra Viehoever

Walden Dissertations and Doctoral Studies

Effective doctor communication is an important determinant of patient satisfaction in inpatient units. The Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey measures patient satisfaction and influences reimbursement rates under the Hospital Value-Based Purchasing Program. The purpose of this retrospective quasi-experimental quantitative study was to examine the possible relationship between doctor communication and patient satisfaction in inpatient units in California. The Donabedian framework provided the theoretical framework to examine possible relationships between the variables. Publicly available data were collected from 290 hospitals in California that participated in the HCAHPS survey between July 2022 and June 2023. Results of …

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The Treatment Experiences Of Female Domestic Violence Offenders Who Have Completed Court-Mandated Counseling Programs, Chelsea S. King Aug 2025

The Treatment Experiences Of Female Domestic Violence Offenders Who Have Completed Court-Mandated Counseling Programs, Chelsea S. King

Walden Dissertations and Doctoral Studies

Domestic violence is a significant societal problem. However, aspects of domestic violence (DV) perpetrated by women are often overlooked or inadequately addressed in existing counseling and intervention programs, leaving counselor educators ill-equipped to effectively train counselors to treat this specific population. The research question addressed the treatment experiences of female DV offenders who completed court-mandated counseling programs. Given the limited current research on female domestic violence offender treatment, Heidegger’s hermeneutic phenomenological methodology was employed to further understand the perspectives of participants, potentially identifying areas of improvement and addressing the needs of female program participants. Semistructured interviews were completed with six …

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Lived Experiences Of Police Officers With Vicarious Sexual Trauma, Resiliency, And Departmental Support, Joseph Schreiner Aug 2025

Lived Experiences Of Police Officers With Vicarious Sexual Trauma, Resiliency, And Departmental Support, Joseph Schreiner

Walden Dissertations and Doctoral Studies

This qualitative study involved addressing lived experiences of police officers who investigate sex crimes. Vicarious sexual trauma experienced by officers can lead to both short- and long-term issues for these individuals, particularly if they are left unaddressed. The constructivist self-development and resiliency theories were used to examine these experiences. Specifically, this study involved investigating how police officers perceived vicarious sexual trauma and viewed the accessibility and practicality of mental health and wellness resources provided by their departments. It was guided by two research questions, which were addressed through 12 semistructured interviews, which were thematically analyzed and interpreted. Five themes emerged …

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Minority Female Political Representation In Westchester County Politics: A View From Minority Female Elected Office Holders, Dwanita Michelle Crosby Aug 2025

Minority Female Political Representation In Westchester County Politics: A View From Minority Female Elected Office Holders, Dwanita Michelle Crosby

Walden Dissertations and Doctoral Studies

African American women have historically been underrepresented in political leadership, a disparity largely attributed to the persistent absence of structured support systems—particularly mentorship—that promote advancement across federal, state, and local levels. Existing literature highlights gender and racial disparities in political trajectories but often overlooked the specific role of mentorship in shaping leadership outcomes for African American women at the municipal level. This gap was particularly critical given the increasing civic engagement and influence of African American women in local governance. The purpose of this general qualitative study was to examine how mentorship shaped the political journeys of African American women …

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Strategies To Reduce Waiting Times In A Hospital Emergency Department, Gillian Denise Browne-Farrell Aug 2025

Strategies To Reduce Waiting Times In A Hospital Emergency Department, Gillian Denise Browne-Farrell

Walden Dissertations and Doctoral Studies

Leaders of the emergency departments (EDs) globally, especially in the United States face persistent challenges addressing staffing issues in the ED and increased wait times. The purpose and review question for this integrative review was to investigate strategies and best practices to decrease waiting times in a hospital ED. The Theory of Constraints framework served as the theoretical foundation for this review. An examination of the literature published within the past five years identified 101 relevant articles. From these articles, 30 empirical and non-empirical articles were selected for further analysis using the Johns Hopkins evidence-based practice model and six major …

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Enhancing Communication Among New Nurses Using Scenario-Based Education, Anita Clark Chambers Aug 2025

Enhancing Communication Among New Nurses Using Scenario-Based Education, Anita Clark Chambers

Walden Dissertations and Doctoral Studies

This staff education project was designed to enhance communication among new nurses with 2 years or less of experience in a Level One trauma center emergency department (ED). The aim of this project initiative was to enhance learners’ communication strategy knowledge and confidence by using scenario-based education via a web-based format. When ineffective communication exchanges occur with healthcare personnel, such as with new nurses, negative patient care outcomes can occur such as sentinel events. Transitional challenges such as lack of prioritization, clinical decision-making skills and low confidence can affect the new nurse’s ability to appropriate effective communication strategies into their …

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Prediction Of Collegial Relationships And Teachers’ Commitment To Stay In A Compulsory Swedish School, Chermaine Clunie Aug 2025

Prediction Of Collegial Relationships And Teachers’ Commitment To Stay In A Compulsory Swedish School, Chermaine Clunie

Walden Dissertations and Doctoral Studies

The problem addressed in this study was the high annual teacher turnover rate of 30% in a Swedish compulsory school, which significantly exceeded national averages. The purpose of this quantitative study was to investigate the relationship between the quality of collegial relationships, as measured by emotional support, task-related support, and feedback from colleagues which are subscales of the workplace social support (WSS) scale, and Swedish teachers’ commitment to stay in their current teaching positions in a Swedish compulsory school, measured on a continuous scale, using a 5 point Likert scale. The study was grounded in Blau’s social exchange theory, which …

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Staff Education To Enhance The Use Of Alternatives To Restrictive Interventions When Managing Aggressive Behaviors, Anthony Obinna Madu Aug 2025

Staff Education To Enhance The Use Of Alternatives To Restrictive Interventions When Managing Aggressive Behaviors, Anthony Obinna Madu

Walden Dissertations and Doctoral Studies

This is a DNP staff education project executive summary aimed at increasing staff knowledge on the use of alternatives to restrictive interventions when managing aggressive behaviors in an inpatient psychiatric unit.

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Management Responses To Staff Speaking Up In The Nhs: A Scoping Review, Melika Ghorbankhani, Aled Jones, Alison James, Ben Hannigan, Dominic Roche Aug 2025

Management Responses To Staff Speaking Up In The Nhs: A Scoping Review, Melika Ghorbankhani, Aled Jones, Alison James, Ben Hannigan, Dominic Roche

School of Nursing and Midwifery

Staff speaking up about patient safety concerns is crucial to improving care and learning from mistakes. Poor management responses to speaking up can result in missed opportunities to prevent harm and hinder staff learning. This scoping review explored the literature on managers' responses to staff-raised patient safety concerns in the NHS, identifying key factors that influence these responses and suggesting strategies for improvement. Arksey and O'Malley's five-stage framework was used to systematically analyse studies from databases such as MEDLINE, PubMed, EMBASE, APA PsycINFO and CINAHL. The review included 25 studies published between 2005 and 2023. Eleven identified studies were based …

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A Force To Be Reckoned: Strategic Equity Sense Leadership Of Unit-Level Higher Education Leaders, Jin M. Mims Aug 2025

A Force To Be Reckoned: Strategic Equity Sense Leadership Of Unit-Level Higher Education Leaders, Jin M. Mims

LMU Theses and Dissertations

The #BlackLivesMatter (#BLM) movement in 2020 pressured higher education institutions to address their oppressive and exclusive systems. As these institutions communicated their diversity, equity, and inclusion, (DEI) commitments and processes, it was those who took charge to facilitate the operational and cultural change for their respective area through the DEI lens, those who assumed DEI roles in their designated units, actualized the ground-level work of designing and implementing DEI programs and policies to produce the institutional progress reported by the university’s executive leadership. I will refer to those change agents as Unit-level DEI Officers (UDOs). Meanwhile, the current body of …

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Impact Of Firefighters' Work Schedule On Cardiovascular Disease Risk, Wellbeing And Safety In Firefighters: Protocol For The Swift Study, A Multidisciplinary Prospective And Cross-Sectional Study, Walaa F. Abdelmoaty, Shelby L. Watkins, Aanuoluwakiitan Ayeni, David A. Hurtado, Andrew W. Mchill, Jeremy J. Biggs, Kurt T. Hegmann, Steven A. Shea, Todd Bodner, Nicole P. Bowles Aug 2025

Impact Of Firefighters' Work Schedule On Cardiovascular Disease Risk, Wellbeing And Safety In Firefighters: Protocol For The Swift Study, A Multidisciplinary Prospective And Cross-Sectional Study, Walaa F. Abdelmoaty, Shelby L. Watkins, Aanuoluwakiitan Ayeni, David A. Hurtado, Andrew W. Mchill, Jeremy J. Biggs, Kurt T. Hegmann, Steven A. Shea, Todd Bodner, Nicole P. Bowles

Psychology Faculty Publications and Presentations

Firefighters face frequent physical and psychosocial stressors, increasing their risk for hypertension. Rising call volumes with a stable workforce have heightened occupational burdens. To meet their occupational demands while increasing time off-duty, fire departments across the country have switched from a 24 hours on 48 hours off (termed ‘24/48’) work schedule to one that increases the number of consecutive days off (eg, 1 day on, 3 days off, 2 days on, 3 days off (termed ‘1/3/2/3’) or 48 hours on 96 hours off (termed ‘48/96’)). However, these schedule changes come at the expense of increasing time on-duty, which may have …

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Inhibition Of Epithelial Cell Yap-Tead/Lox Signaling Attenuates Pulmonary Fibrosis In Preclinical Models, Darcy Elizabeth Wagner, Hani N Alsafadi, Nilay Mitash, Aurelien Justet, Qianjiang Hu, Ricardo Pineda, Claudia Staab-Weijnitz, Martina Korfei, Nika Gvazava, Kristin Wannemo, Ugochi Onwuka, Molly Mozurak, Adriana Estrada-Bernal, Juan Cala-Garcia, Katrin Mutze, Rita Costa, Deniz Bölükbas, John Stegmayr, Wioletta Skronska-Wasek, Stephan Klee, Chiharu Ota, Hoeke A Baarsma, Jingtao Wang, John Sembrat, Anne Hilgendorff, Jun Ding, Andreas Günther, Rachel Chambers, Ivan Rosas, Stijn De Langhe, Naftali Kaminski, Mareike Lehmann, Oliver Eickelberg, Melanie Königshoff Aug 2025

Inhibition Of Epithelial Cell Yap-Tead/Lox Signaling Attenuates Pulmonary Fibrosis In Preclinical Models, Darcy Elizabeth Wagner, Hani N Alsafadi, Nilay Mitash, Aurelien Justet, Qianjiang Hu, Ricardo Pineda, Claudia Staab-Weijnitz, Martina Korfei, Nika Gvazava, Kristin Wannemo, Ugochi Onwuka, Molly Mozurak, Adriana Estrada-Bernal, Juan Cala-Garcia, Katrin Mutze, Rita Costa, Deniz Bölükbas, John Stegmayr, Wioletta Skronska-Wasek, Stephan Klee, Chiharu Ota, Hoeke A Baarsma, Jingtao Wang, John Sembrat, Anne Hilgendorff, Jun Ding, Andreas Günther, Rachel Chambers, Ivan Rosas, Stijn De Langhe, Naftali Kaminski, Mareike Lehmann, Oliver Eickelberg, Melanie Königshoff

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease characterized by excessive extracellular matrix deposition. Current IPF therapies slow disease progression but do not stop or reverse it. The (myo)fibroblasts are thought to be the main cellular contributors to excessive extracellular matrix production in IPF. Here we show that fibrotic alveolar type II cells regulate production and crosslinking of extracellular matrix via the co-transcriptional activator YAP. YAP leads to increased expression of Lysl oxidase (LOX) and subsequent LOX-mediated crosslinking by fibrotic alveolar type II cells. Pharmacological YAP inhibition via verteporfin reverses fibrotic alveolar type II cell reprogramming and LOX …

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Sporadic Als Induced Pluripotent Stem Cell Derived Neurons Reveal Hallmarks Of Tdp-43 Loss Of Function, Jeffrey D Rothstein, Olivia Keeley, Caroline Warlick, Timothy M Miller, Cindy V Ly, Jonathan D Glass, Alyssa N Coyne Aug 2025

Sporadic Als Induced Pluripotent Stem Cell Derived Neurons Reveal Hallmarks Of Tdp-43 Loss Of Function, Jeffrey D Rothstein, Olivia Keeley, Caroline Warlick, Timothy M Miller, Cindy V Ly, Jonathan D Glass, Alyssa N Coyne

2020-Current year OA Pubs

Nuclear loss and cytoplasmic buildup of the RNA-binding protein TDP-43 is a hallmark of ALS and related disorders. While studies using artificial TDP-43 depletion in neurons have revealed changes in gene expression and splicing, their relevance to actual patients remained unclear. Induced pluripotent stem cell (iPSC)-derived neurons (iPSNs) from 180 individuals, including controls, C9orf72 ALS/FTD, and sporadic ALS (sALS) patients were used to generate and analyze ~32,500 qRT-PCR data points across 20 genes which identified variable, time-dependent signatures of TDP-43 loss of function in individual lines. Notably, the same changes were also seen in postmortem brain tissue from the same …

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Mississippi Libraries Volume 87, Number 1 And 2 Aug 2025

Mississippi Libraries Volume 87, Number 1 And 2

Mississippi Libraries

Complete issue of Vol. 87, Nos. 1 and 2 of Mississippi Libraries

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Tax Clinic, Henry J. Ferrero Jr. Aug 2025

Tax Clinic, Henry J. Ferrero Jr.

Tax Adviser

No abstract provided.

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