Digital Commons Network^™

Targeting Rna With Small Molecules Using State-Of-The-Art Methods Provides Highly Predictive Affinities Of Riboswitch Inhibitors, Narjes Ansari, Chengwen Liu, Florent Hédin, Jérôme Hénin, Jay W Ponder, Pengyu Ren, Jean-Philip Piquemal, Louis Lagardère, Krystel El Hage

2020-Current year OA Pubs

Targeting RNA with small molecules represents a promising yet relatively unexplored avenue for the design of new drugs. Nevertheless, challenges arise from the lack of computational models and techniques able to accurately model RNA systems, and predict their binding affinities to small molecules. Here, we tackle these difficulties by developing a tailored state-of-the-art approach for absolute binding free energy calculations of RNA-binding small molecules. For this, we combine the advanced AMOEBA polarizable force field to the newly developed lambda-Adaptive Biasing Force scheme associated to refined restraints allowing for efficient sampling. To capture the free energy barrier associated to challenging RNA …

Gut Complement System: A New Frontier In Microbiota-Host Communication And Intestinal Homeostasis, Xianbin Tian, Lan Zhang, Xinyang Qian, Yangqing Peng, Fengyixin Chen, Sarah Bengtson, Zhiqing Wang, Meng Wu

2020-Current year OA Pubs

The gut microbiota plays a crucial role in maintaining intestinal homeostasis and influencing various aspects of host physiology, including immune function. Recent advances have highlighted the emerging importance of the complement system, particularly the C3 protein, as a key player in microbiota-host interactions. Traditionally known for its role in innate immunity, the complement system is now recognized for its interactions with microbial communities within the gut, where it promotes immune tolerance and protects against enteric infections. This Review explores the gut complement system as a possibly novel frontier in microbiota-host communication and examines its role in shaping microbial diversity, modulating …

A Multicriteria Decision Model For Sustainable Port Functions In Environmental Perspectives

Malaysian Journal of Computing (MJoC)

Port operations, while critical to global trade and economic growth, contribute significantly to environmental pressures through activities such as vessel traffic, cargo handling, dredging, and on-dock transportation, leading to emissions of greenhouse gases and other pollutants. Hence, it is of priority to have a systematic evaluation and prioritization of sustainability measures across port functions. This study employs a multi-criteria decision-making (MCDM) approach, the Analytic Hierarchy Process (AHP), to evaluate and prioritize key functional roles and subfunctions that contribute to port sustainability performance. By engaging expert judgment from two leading ports in Malaysia, the analysis identifies stakeholder priorities on the emphasis …

Designing A Community Based Information System Using Activity Theory A Case Study In Taman Lapangan Jaya, Norsyazwani Hafizah Reduan, Kamalia Azma Kamaruddin

Malaysian Journal of Computing (MJoC)

Effective communication and information sharing are vital for active neighbourhood participation, yet many communities still rely on informal group chats that lead to fragmented updates, lost documents, and frequent miscommunication. This study addresses this gap by applying Activity Theory (AT) to systematically identify requirements for a centralized community communication and information-sharing platform in Taman Lapangan Jaya. Using AT, the seven elements of activity were mapped to reveal key issues such as the communication bottleneck, lack of document accessibility, and unclear division of responsibilities. These findings informed the design of a web-based system featuring structured document repositories, role-based information management, and …

Modified Hungarian Method For Lecturer To Course Assignment A Multi Objective Mathematical Programming Model, Nur Syahirah Ibrahim, Adibah Shuib, Zati Aqmar Zaharudin

Malaysian Journal of Computing (MJoC)

Efficient lecturer-to-course assignment is crucial for ensuring both faculty satisfaction and optimal teaching outcomes in higher education institutions. This study presents an advanced optimization model based on the Modified Hungarian Method (MHM) to address this challenge by integrating lecturers' preference levels and competency scores. While previous research has primarily focused on the traditional Hungarian Method (HM), limited attention has been given to its modified version. Moreover, the incorporation of preference-competency-based criteria in lecturer assignments is still lacking. To bridge these gaps, this study develops a mathematical programming approach to refine the MHM framework. The proposed model, called the Preference-Competency Multi-Objective …

Prevalence Of Risk Factors And Severity Level Of Diabetic Retinopathy In Uitm Medical Specialist Centre:An Ordinal Analysis, Aniza Ayuna Che Jani, Zuraida Khairudin, Nornadiah Mohd Razali, Nor Azimah Abd Aziz, Hezlin Aryani Abd Rahman, Nur Syamimi Haji Abu Bakar

Malaysian Journal of Computing (MJoC)

Diabetic Retinopathy (DR) has become a major concern as the number of diabetic patients who are diagnosed with DR has been on the rise each year. Hence, the adoption of a strategic approach is needed to determine the factors that contribute to the level of severity in DR patients. This research aims to determine the significant risk factors influencing the severity level of DR as well as to evaluate the classification rate between the severity level of 157 patients at UiTM Private Specialist Centre by employing the Ordinal Logistic Regression (OLR) analysis. The study revealed that there were 60 (38%) …

Plasma Proteome Correlations With Liver Stiffness In Pediatric Cholestasis Implicate Epithelial To Mesenchymal Transition, Benjamin L Shneider, Rupa S Kanchi, Sandra L Grimm, Sridevi Devaraj, Juliet Emamaullee, Jeremy Schraw, Philip J Lupo, Jorge A Bezerra, Kathleen M Loomes, John C Magee, Ronald J Sokol, Kasper S Wang, Alyssa Kriegmeier, Evelyn Hsu, Jean P Molleston, Philip Rosenthal, Rohit Kohli, Saul J Karpen, Simon P Horslen, M Kyle Jensen, Arianna Barbetta, Cristian Coarfa

Faculty, Staff and Students Publications

Background: Pediatric cholestatic liver diseases can be characterized by rapidly progressive fibrosis. A multicenter cross-sectional analysis of vibration-controlled elastography in biliary atresia (BA), alpha-1 antitrypsin deficiency (A1AT), and Alagille syndrome (ALGS) was leveraged to interrogate the plasma proteome relative to liver stiffness measurements (LSM).

Methods: Slow off-rate modified aptamer scanning profiling of >7000 proteins in plasma from 187 children with BA (n=93), A1AT (n=31), ALGS (n=46), and healthy pediatric controls (n=17) was performed, and correlations with LSM were undertaken.

Results: There was an abundance of LSM correlated proteins (BA n=2720, A1AT n=694, ALGS n=5968). Interestingly, a distinct plasma proteome was …

Exploring Impacts Of Diversity Ideologies On Allyship (Intergroup Responsiveness), Fiona Nguyen

Dissertations and Theses

Colorblindness and multiculturalism are widely studied diversity ideologies that reflect prominent attitudes about how diversity should be understood and managed, as they can help predict individual behavior. Colorblindness proposes that distinct group identities should be ignored, and can be used to exclude minoritized groups and downplay racial minorities' experiences, whereas multiculturalism embraces and values group differences, can foster inclusive environments for minority groups, and leads to positive intergroup outcomes such as reduced prejudice. Despite much research dedicated to exploring the intergroup outcomes of diversity ideologies, few studies have examined their impacts on specific interpersonal interactions, particularly allyship. Research has defined …

Transdiagnostic Correlates Of Family Accommodation In Anxious Youth, Whitney S Shepherd, Erika S Trent, Orri Smarason, Hannah N Sansone, Daphne M Ayton, Amanda Palo, Abigail E Candelari, Wayne K Goodman, Andrew G Guzick, Eric A Storch

Faculty, Staff and Students Publications

Anxiety disorders are common in children and cause significant impairment. Family accommodation, which refers to behavioral changes that family members make to temporarily alleviate a child’s anxiety, has been linked to child anxiety symptom severity. Although emotional vulnerabilities for anxiety such as emotion dysregulation, anxiety sensitivity, and distress intolerance have been associated with family accommodation, research concerning the relationship between these constructs among anxious youth is limited. We hypothesized that these variables would be uniquely and positively associated with family accommodation and would moderate the relationship between anxiety symptom severity and family accommodation. Treatment-seeking child–parent dyads (N = 90; …

Exploring Patients' Perceptions Of An Advance Care Planning Intervention In The Emergency Department: A Qualitative Study, Youkie Shiozawa, Saaya Morton, Nanako Shirai, Hannah Oelschlager, Lucy Kiernat, Anita N Chary, Anna C Revette, Adrian Haimovich, Smit Desai, Kai-Wei Chang, Shan W Liu, Maura Kennedy, Mara A Schonberg, Kei Ouchi

Faculty, Staff and Students Publications

Objectives: Emergency department (ED) visits offer opportunities for seriously ill patients to formulate future medical care goals, yet ED clinicians lack practical strategies for these conversations. ED GOAL, a behavioral intervention, engages seriously ill yet clinically stable older adults in the ED to address advance care planning (ACP) with their outpatient clinicians. In a randomized trial, goals-of-care documentation was significantly higher in the intervention group compared to controls after three (24.3% vs. 9.9%, p = 0.03) and 6 months (31.4% vs. 12.7%, p < 0.01). This study is a sub-analysis to learn about intervention arm participants' perceived benefits and obstacles of the intervention.

Methods: We conducted semi-structured interviews between October 2022 and August 2024 (N = 52) with intervention-arm patients …

Building The Housing Justice Pipeline: Law Schools’ Role In The Right To Counsel Movement, Erica Braudy, Andrew Scherer, Thomas Honan, Tuhfa Begum ’23

Articles & Chapters

No abstract provided.

Dignity And Deepfakes, Michael Goodyear

Articles & Chapters

Today, we face a dangerous technosocial combination: AI-generated deepfakes and the Internet. Believable and accessible, these deepfakes have already spread sex, lies, and false advertisements across the Internet and targeted everyone from Taylor Swift to middle school students. Dissemination of deepfakes inflicts multifarious dignitary harms against their victims—especially women and LGBTQ+ persons—stripping them of control over their own identities, harming their reputations, and ostracizing them from society through shame.

Yet this is not the first time a new technology for capturing one’s likeness and a method for disseminating images threatened individuals’ dignity. In the late nineteenth century, the right of …

Common Law Notice-And-Takedown, Michael Goodyear

Articles & Chapters

Platform liability is a complex landscape under U.S. law. The immunity for users’ torts provided by Section 230 of the Communications Decency Act has understandably garnered the most attention. In addition, many intellectual property law scholars have also examined the requirements of the Digital Millennium Copyright Act (“DMCA”), which provides safe harbors for users’ copyright infringements. The DMCA enumerates a long series of requirements that online platforms must satisfy to be immunized for their users’ infringements, including a notice-and-takedown regime, a repeat infringer policy, and a prohibition on having the right and ability to control and a direct financial benefit. …

Sustained Response To Pan-Braf Inhibitor Plixorafenib (Fore8394, Plx8394) In A Young Adult With Neurodegenerative Langerhans Cell Histiocytosis, Joanna S Yi, Kathleen S Mccarthy, Kate Mazur, Rebecca Kudlaty, Terry Armstrong, Nilesh Desai, Stacie Peacock Shepherd, Daniel Zinn, Jessica Velazquez, Brooks Scull, Carl Allen, Kenneth Mcclain

Faculty, Staff and Students Publications

No abstract provided.

The Predictability Of Demographic And Job-Related Factors On The General Perceived Self-Efficacy Among High School Counselors, Labryant Benjamin

Dissertations (2016-Present)

The purpose of this study was to examine the predictability of demographic and job-related factors on the General Perceived Self-Efficacy scores among high school counselors in the state of Texas. This study was concerned with the predictability of “demographic factors”, specifically age, gender, ethnicity, marital status, years of experience, degree format, degree level, and “job-related factors”, including type of workload, caseload, support system, role clarity, and school classification, on the general perceived self-efficacy among high school counselors. A predictive correlational research design was utilized in this empirical study. The researcher used a correlational research design to investigate the relationship between …

Cephalopod Consciousness: Asking The Right Questions, Gordon Burghardt

Animal Sentience

Jennifer Mather has provided a comprehensive and fascinating overview of the various cognitive accomplishments of cephalopods and their sensory, behavioral, and neurophysiological attributes. The advances in our understanding of a clade that has been separated from vertebrate evolution by well over half a billion years is a testament to advances in both methodology and the questions we now feel free to address. Mather embeds her review in the issue of consciousness, which is certainly a perennial issue in mental evolution, going back to Romanes and earlier. I argue that the term “consciousness” has such a checkered history and is used …

Repeated Withdrawal Of A Glpr Agonist Induces Hyperleptinemia And Deteriorates Metabolic Health In Obese Aging Um-Het3 Mice, Nisi Jiang, Jiyuan Yin, Noah Lawrence, Jieyi Meng, Laurence T Maeyens, Ziying Xu, Xin Li, Mbolle Ekane, Ariana Chaudhary, Pengju Cao, Guannan Li, Carolina Solis-Herrera, Yi Zhu, Shangang Zhao

Children’s Nutrition Research Center Staff Publications

GLP-1-based therapy is highly effective in combating aging-associated metabolic diseases. However, the metabolic effects of frequent withdrawal from this therapy in aged, obese mice have not been previously studied. In this study, aged obese UM-HET3 mice were assigned to three groups: Group 1 received no liraglutide treatment (Lira OFF); Group 2 underwent 3 cycles of treatment followed by withdrawal (Lira ON/OFF); and Group 3 remained on continuous treatment (Lira ON). As expected, mice in Group 3 showed reduced body weight and food intake, along with improved metabolic health. In contrast, mice in Group 2 developed hyperleptinemia and visceral fat expansion, …

Molecular And Genetic Landscapes Of Retina And Brain Microglia In Neurodegenerative Diseases, Khang Ma, Rinki Ratnapriya

Faculty, Staff and Students Publications

Microglia-driven dysregulation has emerged as a significant underlying mechanism in many neurodegenerative diseases, such as age-related macular degeneration (AMD) and Alzheimer's disease (AD). Although both brain and retinal microglia originate from the yolk sac, it is uncertain whether they share molecular similarities or genetic and molecular foundations related to neurodegenerative diseases. In this study, we examine the transcriptomic and epigenetic profiles of retina and brain microglia through integrative analyses of single-nucleus RNA sequencing (snRNA-seq) and single-nucleus ATAC sequencing (snATAC-seq) from 97 independent human samples across 11 different studies. Our findings reveal that retina and brain microglia share similar expression and …

Effectiveness And Assessment Of A Culturally-Tailored Carbohydrate Counting Tool For South Asians With Diabetes: A Practitioner’S Evaluation, Ashwini Wagle

Faculty Research, Scholarly, and Creative Activity

South Asians are at a higher risk for type 2 diabetes compared to many other racial and ethnic groups. Dietary patterns play a significant role and are a modifiable risk factor. This study aimed to evaluate a South Asian carbohydrate counting tool developed by the researcher, assessed by Registered Dietitians Nutritionists and Certified Diabetes Care and Education Specialists. Using nutrition communication theory and the transtheoretical model, the tool included a comprehensive list of commonly consumed South Asian foods and sample vegetarian and non-vegetarian meals (1800e2100 kcal). Sixty-five participants received the tool and a training slide deck. A 40-item questionnaire assessed …

The Access Assembly: Learning Together, Building Friendships, And Strengthening Our Leadership Capacities, Chandra Turpen, Brianne Gutmann, Robert P. Dalka, Gina M. Quan, Mackenzie Carlson, Joel C. Corbo, Gabrielle Jones-Hall, Megan Marshall Smith, Devyn E. Shafer

Faculty Research, Scholarly, and Creative Activity

Founded in 2014, the Access Network brings together nine student-centered, university-based programs that pursue systemic change towards a vision of a more diverse, equitable, inclusive, and accessible STEM community. Leaders at the Network-level and program-level are either current students (undergraduate or graduate) or young faculty and professional scientists, many of whom started out as student leaders in Access programs. Over the last 9 years, Access has brought people together (virtually or in-person) for an annual event called the "Assembly." Student leaders who attend the Assembly appreciate community-building and networking opportunities that help them build capacity for leading local site programming. …

Consumption Of Plant-Based Meat As An Alternative To Animal Meat: Empirical Evidence On Behavioral Intentions, Deena Al Kalbani, Mohammed Al Rizeiqi, M. R. Razzak, Ismail Al-Bulushi, Adil S. Al-Busaidi, I. Khan, P. Pathare

Journal of Agricultural and Marine Sciences

Empirical evidence indicates that rising consumption of animal meat negatively could contribute to climate change and public health. As a result, meat alternatives such as plant-based meat (PBM) have emerged as a potential solution. However, there seems to be a dearth of insights regarding significant drivers of people’s behavioral intentions (BI) towards PBM. This study leverages the theory of planned behavior to determine whether attitude, social norms, and perceived behavioral control influence BI towards PBM. Survey data was collected from 380 respondents in Oman to test the relationships between the constructs in the research framework. The results indicated that attitude …

Omani Endogenous Plants: A Review Of Phytochemical Analysis And Antioxidant Activities, Al Aufi Najwa, Waly I. Mostafa

Journal of Agricultural and Marine Sciences

Herbal medicines have been used for centuries across various cultures to treat a wide range of illnesses. In recent years, growing research supports the bioactive properties of medicinal plants, including antibacterial, antioxidants, antiviral, anticancer, and antimicrobial activities. This review focuses on seven common endogenous Omani plants—Rumex vesicarius (Humeidh), Pteropyrum scoparium (Sidaf), Haplophyllum tuberculatum (Sazab or Sinan al-Tais), Portulaca oleracea (Baqla or Rjla/Purslane), Fagonia indica (Al-Shukaa), Dodonaea viscosa (Shatt), and Prosopis cineraria (Al Ghaf)—and evaluates their antioxidant and phytochemical properties in the context of chronic disease prevention. The findings highlight the potential of these plants as natural alternatives for managing chronic …

Covid's Impact On Our Youngest Learners, Scottie Ellsworth

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Amanda Obery, PhD; Wendie Castillo

The COVID-19 pandemic profoundly disrupted education, leaving lasting effects on elementary students’ academic development, particularly in literacy and reading comprehension. This research investigated the long-term educational impacts of the pandemic by drawing on qualitative insights from interviews with five educators across a range of specializations, including general education, interventional support, and multilingual learning. Using inductive thematic analysis and descriptive coding, the study identified key themes that reflected shifts in academic achievement, student behavior, attendance, and school priorities post-pandemic. These findings illuminate critical areas where students require support and outline the structural, instructional, and …

Appropriate Blackness: Feminism, C.R.T, Marxism & Boxing, Olene Togiailua

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Cynthia Pengilly, PhD

Black people of the Progressive era were concerned with how to regulate their behavior to better their position in society. This research will examine the synthesis of gender performativity, critical race theory, Marxism, and psychoanalysis to create an assimilation identity strategy called “Appropriate Blackness” and how it is demonstrated through the sport of Boxing. The case study subject of all these different frameworks is the first Black Heavyweight champion of the world, Jack Johnson, who was the premier Black celebrity during the Progressive Era and thus an example for a specific gender strategy many working-class …

Emotion Recognition Accuracy With Fully Occluded Faces: Do Eye Gaze Patterns And Fixation Durations Shift When We're Wrong?​, Dominique Martinez-Driscoll, Michael Cicero, Malcolm Jasmin, Mary Radeke, Anthony Stahelski

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Mary Radeke, PhD; Anthony Stahelski, PhD

Prior research on facial expression recognition (FER) has shown that the use of face masks significantly impairs the ability to correctly identify facial expressions, especially those that engage the lower regions of the face such as disgust and anger (Carbon, 2020; McCrackin et al. 2022). Not only does FER accuracy decrease with a masked or occluded face, but gaze patterns also shift and dwell time increases from those areas that are covered (mouth) to areas uncovered (eyes) (Rabadan, et al. 2022). In situations where both eyes and mouth are covered, the gaze …

Building Career Pathways: Investigating The Potential For A Cooperative Education Program For Graduate Itm Students At Central Washington University, Liam J. E Holland

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Susan Rivera, PhD

This research examines the feasibility of introducing a cooperative education (co-op) program at the master’s level in the Central Washington University (CWU) ITM Department. Methods included a review of existing co-op programs, analysis of interviews with past co-op students, and an examination of survey data on student interest in graduate-level cooperative education. The study aims to identify key elements of effective co-op programs and assess demand for such programs. The analysis of current co-op models offers insights into program structure, industry engagement, and student success. The 2019 NACE Internship & Co-op Survey found that 50.2% …

Optimizing Cybersecurity Through Ai Predictive Analytics And Human Expertise, Cathy Mae C. Dutong

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Hideki Takei, DBA

As cybersecurity threats evolve in complexity and scale, the reliance on artificial intelligence (AI) has become increasingly prevalent across both public and private sectors. This study examines the dual role of AI-driven predictive analytics in strengthening organizational cybersecurity, while addressing the ongoing need for human oversight. Through a mixed-method approach, combining survey data from cybersecurity professionals with an extensive literature review, this research analyzes AI's capacity to detect emerging threats, the systemic challenges associated with AI integration, and the indispensable role of human expertise in interpreting AI outputs. Findings indicate that while AI enhances proactive …

Global Trends In Ai-Driven Product Development: A Cross-Country Analysis, Shilpa Dhananjayan

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Hideki Takei, DBA

Artificial Intelligence (AI) is transforming industries and accelerating global innovation, yet its benefits remain unevenly distributed. A nation’s AI readiness—its capacity to adopt and implement AI technologies—plays a crucial role in economic growth and technological advancement. Key determinants of AI readiness include digital infrastructure, data accessibility, government policies, research and development (R&D) investment, and workforce development. This study examines the relationship between AI readiness, AI adoption, innovation, R&D investment of a nation, Digital Infrastructure Index (DII) and Human Capital Index (HCI) using a Random Forest regression model. Findings reveal a strong correlation between AI adoption …

Focus Group Interview: Perspectives Of Virtual Dietary Counseling Method’S Post Covid-19 Pandemic, Maria Mendoza

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Nicole Stendell-Hollis, PhD; Tafere Belay, PhD; Katy Williams; Jessica Tyrrell

The purpose of this study is to examine the perceptions related to different delivery methods of dietary counseling. This qualitative research study will examine the perceptions related to different methods of dietary counseling (telephone calls, video calls, or face-to-face visits). Focus group one contained provider participants (N = 7), which were all RDNs and focus group two hosted patient participants (N = 6). Semi structured interviews were performed asking subjects about any personal experiences related to receiving or providing nutrition education, positive or negative, as they participated in …

Prevalence Of Diabetes Related To Acculturation, Dietary Quality, And Sedentary Lifestyle In Mexican Americans: National Health And Nutrition Examination Survey 2011 To 2018, Kivima Acevedo

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): David Gee, PhD; Kathaleen Briggs Early, PhD, RDN, CDCES; Katy Williams, MS, RDN

Objective: This study examined the prevalence of diabetes in Mexican American adults (MA-adults) and how risk factors like acculturation, dietary quality, and sedentary lifestyle contribute to the rising rates of diabetes, using the National Health and Nutrition Survey (NHANES) 2011 to 2018 data. Methods: We analyzed the NHANES data of MA-adults and Non-Hispanic White adults (NHW-adults) (n= 10670) for the association of diabetes and its risk factors (dietary habits and sedentary lifestyle) by acculturation levels. Diet quality was assessed using the Healthy Eating Index (HEI). …