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How Rural Public Middle School Teachers Describe The Influence Of Artificial Intelligence Integration On Their Workload Management: A Qualitative Phenomenological Study, Courtnee R. Morris Dec 2025

How Rural Public Middle School Teachers Describe The Influence Of Artificial Intelligence Integration On Their Workload Management: A Qualitative Phenomenological Study, Courtnee R. Morris

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to explore the work processes of public middle school teachers in rural areas of Northwest Ohio regarding the integration of Artificial Intelligence into their professional practice. Work processes were defined as teachers’ perceptions, interactions, and reflections on how AI influenced their workload, instructional practices, and job satisfaction. The Job Demands-Resources model provided the theoretical framework, offering a lens to examine how AI tools functioned as both resources and demands in the teaching environment. This framework helped illuminate the interaction between technology use and educator well-being in rural educational settings. The central research question …

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A Study Of The Relationship Between Emotional Intelligence And Affective Organizational Commitment And Their Effect On Turnover Intentions, David Dix Tomblison Dec 2025

A Study Of The Relationship Between Emotional Intelligence And Affective Organizational Commitment And Their Effect On Turnover Intentions, David Dix Tomblison

Doctoral Dissertations and Projects

This study examined the relationships among emotional intelligence, affective organizational commitment, and turnover intentions among millennial employees in Washington State’s technology sector. A fixed, cross-sectional quantitative design was used with data from 459 participants collected through the Wong and Law Emotional Intelligence Scale, the Meyer and Allen Affective Commitment Scale, and the Cohen Turnover Intention Scale. Statistical analyses were conducted with IBM SPSS Statistics (Version 30; IBM Corp, 2023) for simple regression analysis and the PROCESS Macro (Version 5.0, Model 1) for moderation analysis. Findings showed that emotional intelligence was positively associated with affective organizational commitment and negatively associated with …

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The Effects Of Music Participation On Sense Of Belonging Among Elementary Students With Traumatic Experiences, Jamie Lynn Mckoy Hill Dec 2025

The Effects Of Music Participation On Sense Of Belonging Among Elementary Students With Traumatic Experiences, Jamie Lynn Mckoy Hill

Doctoral Dissertations and Projects

The unexpressed perspectives of children have long been dismissed in elementary music education. Daily agendas, curriculum, and administrative expectations direct the day-to-day functions of the classroom and negate the instructor’s assessment of students’ needs. As a result, students who have experienced trauma (various forms) will feel disconnected from the classroom and have a low level of engagement. Music educators must adapt their planning and execution and infuse empathy and flexibility in their teaching to allow all children room to grieve previous traumatic experiences. This historical research investigates the student perspectives on what music participation means effects on elementary students’ sense …

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Do Games Play A Role In Personal Socialization?, Jasmine Reyna Landry Dec 2025

Do Games Play A Role In Personal Socialization?, Jasmine Reyna Landry

Doctoral Dissertations and Projects

The purpose of this descriptive phenomenological study was to explore how online gamers aged 20 to 40 experience the impact of socialization on self-verification and personal purpose. Semi-structured interviews with eleven participants were conducted, and data were analyzed using Colaizzi’s method to capture the essence of participants lived experiences and the sample population consisted of 12 participants. Findings revealed two overarching themes and in the themes several subthemes that include: Emotional Regulation, Social Presence, Stress Relief, Gaming as Social Connection and Maintenance and lifestyle balance. Participants described gaming as central to sustaining meaningful relationships, regulating stress, exploring identity, and receiving …

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Job-Related Factors Affecting Special Education Teachers In The Pk-12 Classrooms Technology Proficiency: A Predictive Correlational Study, Kreshonya Porter Dec 2025

Job-Related Factors Affecting Special Education Teachers In The Pk-12 Classrooms Technology Proficiency: A Predictive Correlational Study, Kreshonya Porter

Doctoral Dissertations and Projects

The purpose of this predictive correlational study was to determine if a linear combination of job-related factors could predict special education teachers’ technology proficiency. The study is critical because teachers’ technology proficiency in a special education setting directly impacts students’ inclusivity, engagement, productivity, and achievements in the classroom. This study adds to the literature regarding special education teachers’ technology proficiency by examining specific job-related factors (experience, educational level, amount of technology-related professional development training, frequency of technology use, specialty, and job placement). The participants for this study were drawn from the population of special education teachers employed in pre-K through …

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Rewriting Hell: Adaptation, Hope, And The 'American Dream' In Practice-As-Research, Karli Jean Lonnquist Dec 2025

Rewriting Hell: Adaptation, Hope, And The 'American Dream' In Practice-As-Research, Karli Jean Lonnquist

Student Scholar Symposium Abstracts and Posters

Contemporary theatrical adaptation involves deconstructing, reimagining, and rewriting historical plays for modern audiences. Adaptation appropriates theatrical conventions, changes the lens through which the audience may view the play, and offers new entry points into thinking and practice. Adaptation asks, “why this source as theatre now?” and proposes that history provides tools for engagement with contemporary issues. By employing a Practice as Research methodology, which positions creative processes such as script development, rehearsal, or play development as research methods, I investigated the art of historical adaptation. I adapted No Exit, a 1945 existentialist play by Jean-Paul Sartre, into a new play …

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Diary Of A Young Actress: An Inquiry Into Failure, Resilience, And The Actor’S Journey, Keira Biala Dec 2025

Diary Of A Young Actress: An Inquiry Into Failure, Resilience, And The Actor’S Journey, Keira Biala

Student Scholar Symposium Abstracts and Posters

What is the journey? For some, it may be a road to a physical destination. For others like myself, it is a pathway containing failures such as rejection and successes such as booking roles. Sometimes, these failures can challenge our sense of self, leading to unhealthy coping mechanisms. As a deep exploration of self-comparison, self-worth, and rejection in people’s artistic and non-artistic journeys, I created an album called Diary of a Young Actress consisting of self-written songs about these three topics when it comes to my acting journey. Moreover, I read books and articles about people’s perspectives on their journeys …

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Criminalizing Difference: An Intersectional Analysis Of Disability In The Criminal Justice System, Rowan Eisleman Dec 2025

Criminalizing Difference: An Intersectional Analysis Of Disability In The Criminal Justice System, Rowan Eisleman

Student Scholar Symposium Abstracts and Posters

This research addresses the central question: How do individuals with disabilities intersect with the criminal justice system, and what systemic factors contribute to their overrepresentation and victimization? Despite over 61 million Americans having disabilities, there exists a significant gap in comprehensive scholarship examining disability-criminal justice intersections, particularly regarding how people with intellectual and developmental disabilities experience unique vulnerabilities as both offenders and victims. This study contributes to disability studies and criminology by providing a comprehensive intersectional analysis examining how disability compounds with race and gender to create compounded marginalization. This study conducted a comprehensive literature review, analyzing government statistics from …

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The Role Of Artificial Intelligence In Reducing Internet Crimes Against Children, Malyssa Shaw Dec 2025

The Role Of Artificial Intelligence In Reducing Internet Crimes Against Children, Malyssa Shaw

Student Scholar Symposium Abstracts and Posters

When generative artificial intelligence (AI) first surfaced and broke into the public sphere, my immediate concern was in its development, implementation, and harmful applications. I was not surprised when deepfake technology rapidly advanced alongside these new developments and impacted women and children worldwide. Disproportionately, they have been made victims of intimate media forgery as early as the 1990s, with an unprecedented uptick in recent years as a direct result of these developments. In response, I wrote "Deepfake, Real Harm: Protecting Children in the Age of AI", analyzing data specifically regarding child sexual abuse material (CSAM) created with artificial intelligence while …

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Defining Immersive Theatre Creation For Stage Managers’ Benefit, Alivia Infeld Dec 2025

Defining Immersive Theatre Creation For Stage Managers’ Benefit, Alivia Infeld

Student Scholar Symposium Abstracts and Posters

Creating immersive theatre differs from traditional theatre in its use of found spaces that lack visual barriers between the audience and the performers. Additionally, the order of scenes are performed in can change for each performance. The delineation of scenes is often defined by a change in location or scheduled time. For these reasons and more, immersive theatre presents many unique challenges for artists working in this medium. In particular, the role of stage managers is complicated by the opportunity for complications inherent in performances featuring audience interaction in close quarters. Audience behavior is at once both an unknown variable …

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December 4, 2025, The Daily Mississippian Dec 2025

December 4, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

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Exploring The Clinical Utility Of The Adult Social Care Outcomes Toolkit For Use In Occupational Therapy Practice In Adult Social Care: A Qualitative Study, Rachel Cox, Sarah Reynolds Dec 2025

Exploring The Clinical Utility Of The Adult Social Care Outcomes Toolkit For Use In Occupational Therapy Practice In Adult Social Care: A Qualitative Study, Rachel Cox, Sarah Reynolds

School of Health Professions

AbstractBackground/Aims Promoting the wellbeing of service users is a core focus in occupational therapy and adult social care. Despite a professional, policy and legal mandate to provide evidence of the effectiveness of occupational therapy interventions in adult social care, few local authority teams in England use standardised outcome measures to assess the impact of interventions on wellbeing. One local authority’s occupational therapy service in England sought to address this by introducing the Adult Social Care Outcomes Toolkit. This study explored the Adult Social Care Outcomes Toolkit’s clinical utility (usefulness) in this setting. As the Adult Social Care Outcomes Toolkit has …

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Basil_Dock: Development Of Accessible And Customizable Molecular Docking Procedures, Lee Schoneman Dec 2025

Basil_Dock: Development Of Accessible And Customizable Molecular Docking Procedures, Lee Schoneman

Theses

Molecular docking is a computational technique often used in drug design due to its ability to predict ligand binding potential, conformation, and location for a given drug target. Docking as a screening tool also comes at a greatly reduced cost compared to wet bench work. Despite its usefulness, molecular docking is often inaccessible to novice users, as to perform molecular docking, most programs require at least a basic knowledge of command line and computer programming for both installation and utilization. Additionally, tutorials for the most popular programs tend to be inflexible, instructing how to bind predetermined molecules to a specified …

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Toward A Roadmap For Addressing Today's Health Dilemma-The 101-Statement Consensus Report, Katharina C. Wirnitzer, Mohamad Motevalli, Derrick R. Tanous, Clemens Drenowatz, Maximilian Moser, Holger Cramer, Thomas Rosemann, Karl-Heinz Wagner, Andreas Michalsen, Beat Knechtle, Zlatko Fras, Merel Ritskes-Hoitinga, Adilson Marques, Natasa Fidler Mis, Fatima C. Stanford, Christian Schubert, Nandu Goswami, Claus Leitzmann, Per Morten Fredriksen, Gerhard Ruedl, Doris Wilflingseder, Rodrigo A. Lima, Christian Kessler, Michael Jeitler, Naim A. Khan, Hassan Joulaei, Maryam Fatemi, Andrew Knight, Karl W. Kratky, Kara K. Palmer Dec 2025

Toward A Roadmap For Addressing Today's Health Dilemma-The 101-Statement Consensus Report, Katharina C. Wirnitzer, Mohamad Motevalli, Derrick R. Tanous, Clemens Drenowatz, Maximilian Moser, Holger Cramer, Thomas Rosemann, Karl-Heinz Wagner, Andreas Michalsen, Beat Knechtle, Zlatko Fras, Merel Ritskes-Hoitinga, Adilson Marques, Natasa Fidler Mis, Fatima C. Stanford, Christian Schubert, Nandu Goswami, Claus Leitzmann, Per Morten Fredriksen, Gerhard Ruedl, Doris Wilflingseder, Rodrigo A. Lima, Christian Kessler, Michael Jeitler, Naim A. Khan, Hassan Joulaei, Maryam Fatemi, Andrew Knight, Karl W. Kratky, Kara K. Palmer

School of Health Professions

Importance: In recent decades there has been an expansion in the quantity and quality of scientific findings and guidelines on different health topics to promote individual and public health status. Reports also indicate that there has been a simultaneous increase in the financial burden of disease, including trillions spent on healthcare resources by governments worldwide (predominantly in developing countries) to address health concerns. At the same time, personal health behavior is well-known as efficient and cost-free, holding four times the potential to prevent early death compared to health care. Despite this knowledge, data show that the increasing prevalence of unhealthy …

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Exploring The Academic Self-Advocacy Experiences Of African American Female College Students With Attention Deficit Hyperactivity Disorder (Adhd), Temetric Reeves Dec 2025

Exploring The Academic Self-Advocacy Experiences Of African American Female College Students With Attention Deficit Hyperactivity Disorder (Adhd), Temetric Reeves

Electronic Theses and Dissertations Archive

Despite available resources for students with disabilities, AA female college students with ADHD continue to experience academic challenges that threaten their graduation goals. Students with ADHD are not graduating at the same level as their non-ADHD peers, which may often be due to inefficient academic self-advocacy skills that can address intersectional oppression. College students with ADHD often face academic challenges that contribute to lower graduation rates compared to their non-ADHD peers. African American women similarly experience lower graduation rates compared to their white peers. When combined, these intersecting factors highlight the compounded barriers African American female college students with ADHD …

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2025-12-04 Faculty Senate Meeting Minutes, Morehead State University. Faculty Senate. Dec 2025

2025-12-04 Faculty Senate Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from December 4, 2025.

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The Error Of Replacement Theology, Its Significance For Christians Today, And Its Theological Implications For Participants In The Vintage Truth Bible Study, Jeffery Bruce Kinley Dec 2025

The Error Of Replacement Theology, Its Significance For Christians Today, And Its Theological Implications For Participants In The Vintage Truth Bible Study, Jeffery Bruce Kinley

Doctoral Dissertations and Projects

The nation of Israel regularly makes geopolitical and cultural headlines, and antisemitism continues to increase on a global scale. This carries profound theological and practical implications regarding Israel’s relationship and relevance to the Church. This DMin action research project was designed and implemented to evaluate the impact of replacement theology on approximately thirty participants in the Vintage Truth Bible Study. Through a sustained, eight-week study examining the tenets of replacement theology, along with Scripture’s teaching on God’s relationship with and covenants to Israel, and prophecies regarding that nation’s future, the doctrine was addressed. The research combined thorough biblical exposition, three …

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Exploring Veterans' Experiences And Perceptions Of Mental Health Support: A Comparative Study Of Va Services Versus Civilian Mental Health Services, Jameelah Johnson Dec 2025

Exploring Veterans' Experiences And Perceptions Of Mental Health Support: A Comparative Study Of Va Services Versus Civilian Mental Health Services, Jameelah Johnson

Doctoral Dissertations and Projects

This phenomenological investigation aimed to describe and interpret the experiences of veterans who received mental health care from veterans at Veterans Administration (VA) facilities and civilian healthcare providers in the Mid-Atlantic region. The investigation examined the complex issues veterans encounter when accessing mental healthcare through both VA services and civilian providers. The research investigated veterans' views on essential elements such as trustworthiness, cultural competence within care systems, accessibility to services, and the quality of therapeutic relationships. The framework helped us comprehend how veterans’ attitudes, together with their subjective norms and perceived behavioral control, shape their decisions about using mental health …

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Examining The Influence Of Education On Job Satisfaction Among Georgia Police Officers: A Causal-Comparative Quantitative Analysis, Ebony J. Gammon Dec 2025

Examining The Influence Of Education On Job Satisfaction Among Georgia Police Officers: A Causal-Comparative Quantitative Analysis, Ebony J. Gammon

Doctoral Dissertations and Projects

The purpose of this quantitative causal-comparative study was to determine if a significant difference exists between job satisfaction scores among police officers with varying levels of education. This study is important because it addresses contemporary challenges in law enforcement, will provide valuable insight into informed decision making, has broad implications and applicability, and will contribute to scant policing knowledge that informs the understanding of education level on police actions. More specifically, how higher education or the absence thereof impacts job satisfaction. The sample was composed of 180 sworn Peace Officer Standards and Training (POST) certified, police officers in the state …

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Developing Healthy Leaders For Multiplication At The Bridge Church, Joshua D. Robinson Dec 2025

Developing Healthy Leaders For Multiplication At The Bridge Church, Joshua D. Robinson

Doctoral Dissertations and Projects

The problem addressed in this DMIN action research project is the lack of a clearly defined biblical framework for the ongoing leadership development at TBC in Venice, Florida, amid rapid growth and increasing attendance. This gap has hindered the equipping of leaders to disciple and lead others and fulfill the Great Commission through church multiplication. The purpose of this project was to design and implement a biblically grounded leadership pathway, including The Bridge Institute (TBI), to equip current and future servant leaders for maturity, relational authenticity, and missional impact. The goals included developing improved assimilation, increasing volunteer engagement, and creating …

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Impact Of A Pandemic On Clinical Research Organization Ethics: A Case Study, Supakan Apiratanapimonchai Dec 2025

Impact Of A Pandemic On Clinical Research Organization Ethics: A Case Study, Supakan Apiratanapimonchai

Doctoral Dissertations and Projects

The purpose of this research is to examine the post-COVID ethical issues among clinical trials at clinical research organizations (CROs) in the Eastern region. This research is theoretically underpinned by the premise of evaluating the impact of post-COVID on data transparency, ethical guidelines, and protocol compliance. The institutional theory posits that insights gained from this comparative analysis will also contribute to the broader discourse on safeguarding research integrity. According to Yin, case studies are the most beneficial study design to be used, consisting of quantitative approaches (Yin, 2018). The data collected from clinical research associates (CRAs) with experience working with …

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A Causal-Comparative Study Of The Gender And Generational Differences In Emotional Intelligence Of Leaders Within Asset Management Firms, Vanessa Gower Dec 2025

A Causal-Comparative Study Of The Gender And Generational Differences In Emotional Intelligence Of Leaders Within Asset Management Firms, Vanessa Gower

Doctoral Dissertations and Projects

This study aimed to address the challenge some leaders face in managing their emotional intelligence across gender and generational differences. Emotional intelligence is a predictor of effective leadership; therefore, differences in emotional intelligence may result in poor leadership behavior. This study employed a fixed, quantitative, and causal-comparative research design to measure the differences in emotional intelligence among leaders of asset management firms based on gender male and female) and generational groups Baby Boomer, Generation X, and Millennial). Emotional intelligence was measured using the Wong and Law Emotional Intelligence Scale (WLEIS). Leaders of asset management firms within the financial services industry …

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Treatment Concerning Grief Disorder After Covid-19: Can Spiritual Care Help?, Tamika Marie Johnson Dec 2025

Treatment Concerning Grief Disorder After Covid-19: Can Spiritual Care Help?, Tamika Marie Johnson

Doctoral Dissertations and Projects

The phenomenological study described the experiences of spiritual care for adults who lost a loved one due to COVID-19 in Texas. The theory guiding the study was Viktor Frankl’s logotherapy, which was humanity’s search for meaning in a finite world governed by spiritual principles (García-Alandete, 2024; Parker, 2022; Seligman & Reichenberg, 2014). Grief was one of the occurrences that grappled with humanity’s understanding of life. Death was a universal phenomenon, and grief occurred as a response to a loss (Fernández & González-González, 2022). Research shows that symptoms of grief dissipate over time. When it was accompanied by prolonged time or …

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Exploring The Predictive Relationship Between Course Clarity And Utility Value On Engagement For Online Post-Secondary Students In Canada, Amanda Marie Smith Dec 2025

Exploring The Predictive Relationship Between Course Clarity And Utility Value On Engagement For Online Post-Secondary Students In Canada, Amanda Marie Smith

Doctoral Dissertations and Projects

The purpose of this quantitative, predictive, correlational study was to examine how well course clarity and utility value predict student engagement among online learners at a Canadian post-secondary institution. This study is important because it can provide educators and curriculum developers with insights into the factors that positively impact student engagement. Supporting student engagement ensures learners receive a beneficial education and that the institution delivers relevant, engaging programming to retain its students. The sample comprised 68 online post-secondary learners studying at a college in Canada. Data were collected using portions of the Online Learning Climate Scale, the Expectancies and Values …

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Academic Opportunities: A Phenomenological Study Of The Lived Experiences Of Principals That Foster Academic Achievement Of Students That Attend Secondary Title I Schools, Loretta O'Nita Speller Dec 2025

Academic Opportunities: A Phenomenological Study Of The Lived Experiences Of Principals That Foster Academic Achievement Of Students That Attend Secondary Title I Schools, Loretta O'Nita Speller

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study is to explore the lived experiences of principals fostering the academic achievement of students in grades six through twelve who attend public secondary, Title I schools. The theory guiding this study was Maslow’s Hierarchy of needs. Maslow’s theory posits that if a person’s lower-level deficiency needs are not met, ascension to higher levels cannot happen. The central research question is: “What are the lived experiences of principals that lead secondary Title I schools and how do they foster academic achievement of their students?” Purposeful sampling was used in this study, and participants in …

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A Causal-Comparative Study On The Impact Of Digital Learning Competency Professional Development And Socioeconomic Status On Teacher Digital Self-Efficacy, Sabrina C. Steigelman Dec 2025

A Causal-Comparative Study On The Impact Of Digital Learning Competency Professional Development And Socioeconomic Status On Teacher Digital Self-Efficacy, Sabrina C. Steigelman

Doctoral Dissertations and Projects

The purpose of this quantitative study was to examine the relationship between teacher self-efficacy, participation in digital learning professional development, and the socioeconomic status of schools. A causal-comparative design was used to investigate how these variables influenced teacher self-efficacy in implementing digital learning strategies aligned with the International Society for Technology in Education (ISTE) standards. The sample included K-12 educators from public schools across North Carolina, representing both low and mid- socioeconomic school settings. Data were collected through a Qualtrics survey, which included the Technology Integration Confidence Scale Version 3 (TICS V.3) and a demographic questionnaire. A two-way ANOVA was …

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Exploring Gen Z Adults From Military Families: Perspectives On Work Ethics And Values, Sonia Lee Dec 2025

Exploring Gen Z Adults From Military Families: Perspectives On Work Ethics And Values, Sonia Lee

Doctoral Dissertations and Projects

This research explored the work ethics and values of Generation Z (Gen Z) adults who grew up in military-connected households. The purpose was to identify strategies that enhance organizational recruitment, retention, and engagement. Qualitative research methods, such as interviews and thematic analysis, were used to achieve this objective. Insights into how Gen Z adults from military households perceive their work ethic, prioritize their values in the workplace, and how organizations can integrate those values were gained. Findings revealed that discipline, dependability, excellence, responsibility, integrity, respect, and adaptability defined their work ethic, reflecting values shaped by their upbringing. Participants also expressed …

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A Hermeneutic Phenomenology Study: How Students Affected By Trauma Experience Transformative Learning Through Digital Tools, Anita Sarah Chen Dec 2025

A Hermeneutic Phenomenology Study: How Students Affected By Trauma Experience Transformative Learning Through Digital Tools, Anita Sarah Chen

Doctoral Dissertations and Projects

The purpose of this hermeneutical phenomenological study is to explore the lived experiences of adolescent students affected by trauma embarking on the transformative learning process as facilitated by digital learning tools. The theory used to guide the study will be the transformative learning theory by Jack Mezirow. The central research question is: How do students affected by trauma experience transformative learning through digital learning tools? Examining students affected by trauma undergoing the transformative learning process facilitated by digital learning tools will be explored using a hermeneutical qualitative design. Ten participants w selected through purposive sampling based on their experiences in …

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Internal Coherence Factors Of Instructional Leadership Teams And Their Impact On Student Academic Growth: A Quantitative Predictive Correlational Study, Jennifer E. Clark Dec 2025

Internal Coherence Factors Of Instructional Leadership Teams And Their Impact On Student Academic Growth: A Quantitative Predictive Correlational Study, Jennifer E. Clark

Doctoral Dissertations and Projects

The purpose of this quantitative, predictive correlational study is to examine the relationship that the Internal Coherence Framework factors of leadership, teacher collaboration, and collective teacher efficacy have on student academic growth measured through teacher VAM scores. This study has significance, in that, it demonstrates how Instructional Leadership Teams (ILTs) based on the Internal Coherence Framework, through intentional focus on strengthening pedagogy and collective teacher efficacy, impact student achievement at the secondary school level. Junior high and high school teachers who receive VAM scores from thirteen junior high schools and eight suburban high schools in southeast Louisiana responded to the …

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Discovery Of A Small Molecule Tlr3 Agonist Adjuvant, Branden Lee, Danica Dong, Etsuro Nanishi, John Mark Awad, Kimia Abedi, Yoshine Saito, Francesco Borriello, Soumik Barman, Byron Brook, Aisling Kelly, Manisha Menon, Constance Marques-Mourlet, Maansi Gupta, Ida Lister, Chiwoo Oh, Kevin Lyskawa, Morgan Goetz, Kristina Walker, Wing Ki Cheng, Spencer Brightman, Pankaj Sharma, Timothy O'Meara, Katherine Chew, Daniel Vieira, Kevin Ryff, Cali Sweitzer, Sanya Thomas, Simon Van Haren, Matthew Pettengill, Hyuk-Soo Seo, Sirano Dhe-Paganon, Wei Zhang, Ofer Levy, David Dowling Dec 2025

Discovery Of A Small Molecule Tlr3 Agonist Adjuvant, Branden Lee, Danica Dong, Etsuro Nanishi, John Mark Awad, Kimia Abedi, Yoshine Saito, Francesco Borriello, Soumik Barman, Byron Brook, Aisling Kelly, Manisha Menon, Constance Marques-Mourlet, Maansi Gupta, Ida Lister, Chiwoo Oh, Kevin Lyskawa, Morgan Goetz, Kristina Walker, Wing Ki Cheng, Spencer Brightman, Pankaj Sharma, Timothy O'Meara, Katherine Chew, Daniel Vieira, Kevin Ryff, Cali Sweitzer, Sanya Thomas, Simon Van Haren, Matthew Pettengill, Hyuk-Soo Seo, Sirano Dhe-Paganon, Wei Zhang, Ofer Levy, David Dowling

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Pattern-recognition receptor (PRR) agonists are valuable agents across multiple medical applications, from vaccinology to immune-oncology. However, well-defined and potent small molecule agonists for many PRRs still await discovery and development. Screening of chemical libraries of ~200,000 small molecules for maturation of human monocytic cells by quantifying NF-κB activation and cell adherence was completed. From this screen, we selected a thiazole benzamide derivative, PVP-057, for its robust immunomodulatory properties, low toxicity profile, and concentration-dependent activity. In vitro investigation of pathway and receptor activation reveals that PVP-057 is a Toll-like receptor 3 (TLR3) agonist. As a single-component adjuvant, administered intramuscularly or intradermally …

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