Digital Commons Network^™

Primary Care Experiences Of Adults Reporting Learning Disability: A Probability Sample Survey, Rohit Shankar

Peninsula Medical School

BACKGROUND: Adults with learning disability face multiple adversities, but evidence on their needs and primary care experiences is limited.

AIM: To compare the characteristics and primary care experiences of adults reporting learning disability with those who did not.

DESIGN AND SETTING: This was an analysis of the 2022 General Practice Patient Survey, a national probability sample survey conducted in 2022 with people registered with NHS primary care in England.

METHOD: This analysis reports descriptive profiles, weighted and with 95% confidence intervals. Logistic regression models adjusting for gender, age, ethnicity, and area-level deprivation compared experiences of adults reporting learning disability with …

Performance Of A Bipolar Output Voltage Dc-Dc Converter For Voltage Regulation For Solar Pv System Application, Stampinus M. Stephano, Jackson. J. Justo, Bakari M. M. Mwinyiwiwa

Tanzania Journal of Science

A combined Single-Ended Primary-Inductor Converter (SEPIC) and Cuk DC-DC converter that provides a bipolar outputs voltage at the DC bus is widely used in applications especially solar photovoltaic (SPV) system. Maintaining constant output voltages at the DC bus under variable loads and input voltage from SPV is of great interest to many researchers. This paper presents a 400 W mathematical model of a combined SEPIC and Cuk DC-DC converter through state space averaging (SSA) in a continuous conduction mode (CCM). A nested voltage and current control loops are used to regulate voltage and increase the performance of the converter. These …

Author Correction: Longitudinal Single-Cell Profiling Reveals Molecular Heterogeneity And Tumor-Immune Evolution In Refractory Mantle Cell Lymphoma, Shaojun Zhang, Vivian Changying Jiang, Guangchun Han, Dapeng Hao, Junwei Lian, Yang Liu, Qingsong Cai, Rongjia Zhang, Joseph Mcintosh, Ruiping Wang, Minghao Dang, Enyu Dai, Yuanxin Wang, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Jia Zhou, Rashmi Kanagal-Shamanna, Chi Young Ok, Hun Lee, Raphael E Steiner, Jianhua Zhang, Xingzhi Song, Ranjit Nair, Sairah Ahmed, Alma Rodriquez, Selvi Thirumurthi, Preetesh Jain, Nicolaus Wagner-Bartak, Holly Hill, Krystle Nomie, Christopher Flowers, Andrew Futreal, Linghua Wang, Michael Wang

Faculty, Staff and Student Publications

No abstract provided.

A Geospatial Approach To Landscape Gaze Using Social Media To Evaluate How People Value Landscapes In An Urban Context, Riley Bibaud, Eva Mcgrath, Zoe Sydenham, Richard Yarwood, Tom Mullier, Siân Rees

School of Biological and Marine Sciences

Urban park management generally prioritises green spaces and activities within park boundaries, rather than landscape interactions. Understanding how people experience and connect with broader landscapes is essential for improving societal environmental, economic and wellbeing outcomes. A geospatial and discourse analysis of three urban parks was conducted in Plymouth, UK. The predominant landscape gaze at each park revealed strong social ties to blue spaces–namely the coast and sea–indicating an interconnectedness between parks and coastal spaces beyond park boundaries. Textual analysis emphasised the beauty of nature, the expanse of the ocean, and the health and wellbeing benefits of blue and green spaces. …

Faculty Senate Agenda October 7, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order
• Approval of Minutes
• 3:05 University Business
• 3:20 Faculty Senate Business
• 3:35 Information
• EPC Report
• Human Resources Policies 330 & 392
• 3:55 Report
• Educational Policies Committee Annual Report
• Honors Annual Report
• 4:05 Old Business
• 4:10 New Business
• Adjourn: 4:30 pm

Cmsi Translations #8: U.S.-Philippine Military Cooperation In The South China Sea: Challenges And Responses, Zhang Yilong

CMSI Translations

With the new generation of Philippine government taking office, U.S.-Philippines relations have rapidly warmed, and the depth and breadth of their military cooperation have increased. This has brought new challenges and threats to China’s national security. How to deal with these challenges will be a difficult problem before us.

Chimes: October 7, 2024, Calvin University

Chimes

CERF: A look at Calvin's best kept sustainability secret by Ian Tjoelker

"Over All This, Put On Love": building effective political dialogue on campus by Graham Kort

The changing face of world Christianity: a Q&A with Dr. Damaris Parsitau by Ethan Meyers

French Film Festival: A Celebration of Culture and Film by Natasha Jayaputra

Big sport milestones for homecoming weekend by Dillion Baumchen

A look at how campus offices are adapting to digitally immersed students by Elisabeth Stevens

Lord of the Sabbath by Ashley Hamons

The Fundamentals Of Antiseizure Medications: A Through Z, Timothy E Welty, Jeannine M Conway, Jacquelyn Bainbridge, Kristen Park, David G Vossler, Archana A Patel, Alica Goldman

Faculty, Staff and Students Publications

Since bromides were first used in 1857 to treat epilepsy, numerous antiseizure medications (ASM) have been developed. Many of these are available for the treatment of epilepsy and status epilepticus today. With so many ASM available, questions arise as to whether all of these medications are needed and when should they be used. As precision medicine begins to play a larger role in determining targeted treatments for specific types of epilepsy, a complete understanding of various medications is needed. Additionally, access to several of these medications can be limited in the United States and are especially limited globally. All these …

Genomics Of Natural Populations: Gene Conversion Events Reveal Selected Genes Within The Inversions Of Drosophila Pseudoobscura, Stephen W Schaeffer, Stephen Richards, Zachary L Fuller

Faculty, Staff and Students Publications

When adaptive phenotypic variation or quantitative trait loci map within an inverted segment of a chromosome, researchers often despair because the suppression of crossing over will prevent the discovery of selective target genes that established the rearrangement. If an inversion polymorphism is old enough, then the accumulation of gene conversion tracts offers the promise that quantitative trait loci or selected loci within inversions can be mapped. The inversion polymorphism of Drosophila pseudoobscura is a model system to show that gene conversion analysis is a useful tool for mapping selected loci within inversions. D. pseudoobscura has over 30 different chromosomal arrangements …

Trβ Activation Confers At2-To-At1 Cell Differentiation And Anti-Fibrosis During Lung Repair Via Klf2 And Cebpa, Xin Pan, Lan Wang, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li, Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng Li, Saiya Guo, Peishuo Yan, Chen Ding, Ivan O Rosas, Guoying Yu

Faculty, Staff and Students Publications

Aberrant repair underlies the pathogenesis of pulmonary fibrosis while effective strategies to convert fibrosis to normal regeneration are scarce. Here, we found that thyroid hormone is decreased in multiple models of lung injury but is essential for lung regeneration. Moreover, thyroid hormone receptor α (TRα) promotes cell proliferation, while TRβ fuels cell maturation in lung regeneration. Using a specific TRβ agonist, sobetirome, we demonstrate that the anti-fibrotic effects of thyroid hormone mainly rely on TRβ in mice. Cellularly, TRβ activation enhances alveolar type-2 (AT2) cell differentiation into AT1 cell and constrains AT2 cell hyperplasia. Molecularly, TRβ activation directly regulates the …

Human Epidemiology And Response To Sars-Cov-2 (Heros): Objectives, Design, And Enrollment Results Of A 12-City Remote Observational Surveillance Study Of Households With Children, Using Direct-To-Participant Methods, Patricia C Fulkerson, Katherine Rivera-Spoljaric, Et Al.

2020-Current year OA Pubs

The Human Epidemiology and Response to SARS-CoV-2 (HEROS) Study is a prospective, multicity, 6-month incidence study conducted from May 2020 to February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and household transmission among children and people with asthma and allergic diseases, and to use the host nasal transcriptome sampled longitudinally to understand infection risk and sequelae at the molecular level. To overcome challenges of clinical study implementation due to the coronavirus pandemic, this surveillance study used direct-to-participant methods to remotely enroll and prospectively follow eligible children who are participants in other National Institutes of Health-funded pediatric …

Xenotransplanted Human Organoids Identify Transepithelial Zinc Transport As A Key Mediator Of Intestinal Adaptation, Maame Efua S Sampah, Vered Gazit, Deborah C Rubin, Et Al.

2020-Current year OA Pubs

Short bowel syndrome (SBS) leads to severe morbidity and mortality. Intestinal adaptation is crucial in improving outcomes. To understand the human gene pathways associated with adaptation, we perform single-cell transcriptomic analysis of human small intestinal organoids explanted from mice with experimental SBS. We show that transmembrane ion pathways, specifically the transepithelial zinc transport pathway genes SLC39A4 and SLC39A5, are upregulated in SBS. This discovery is corroborated by an external dataset, bulk RT-qPCR, and Western blots. Oral zinc supplementation is shown to improve survival and weight gain of SBS mice and increase the proliferation of intestinal crypt cells in vitro. Finally, …

An Iron-Rich Subset Of Macrophages Promotes Tumor Growth Through A Bach1-Ednrb Axis, Ian W Folkert, Mai T Dang, Et Al.

2020-Current year OA Pubs

We define a subset of macrophages in the tumor microenvironment characterized by high intracellular iron and enrichment of heme and iron metabolism genes. These iron-rich tumor-associated macrophages (iTAMs) supported angiogenesis and immunosuppression in the tumor microenvironment and were conserved between mice and humans. iTAMs comprise two additional subsets based on gene expression profile and location-perivascular (pviTAM) and stromal (stiTAM). We identified the endothelin receptor type B (Ednrb) as a specific marker of iTAMs and found myeloid-specific deletion of Ednrb to reduce tumor growth and vascular density. Further studies identified the transcription factor Bach1 as a repressor of the iTAM transcriptional …

Batching Of Communications Between A Phone And A Wearable Device, Sudeep Chauhan, Andy Killen, Eusebius Lai

Defensive Publications Series

A wearable computing device (e.g., a smartwatch, smart glasses, computerized ring, etc.) may utilize contextual signals to determine when to enable or disable batching of information (e.g., messages, notifications, system data, application data, etc.) between the wearable computing device and a companion device (e.g., a smartphone, portable computer, etc.). The contextual signals may include a state of the user (i.e., user scenarios), device configuration information, and context information such as location, time, user behavior history, calendar events, battery level information (e.g., amount of charge), and/or other relevant data. A user may not want, need, or access information sent to the …

Protecting Students' Privacy: Expanding The Use Of Pseudonyms In Civil Litigation Concerning Sexual Assault At Colleges In The United States And Canada, Cassi Epstein

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

The New Age Of Mining: Isa's Vision Of The Deep Seabed Mining, Ganeswar Matcha

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Rethinking United States - Certain Measures On Steel And Aluminum Products: Rebalancing Should Be Allowed For The Section 232 Measures, Michiru Ishihara, Hiroaki Chiba-Okabe

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

The Digitization Of Trade And Artificial Intelligence: A Pandora's Box, Rafael Leal-Arcas, Lama Al Damer, Haya Al Hokail, Sultana Abdulhakim Al Saud, Salma Alshaikh, Sultana Faisal Al Saud, Sara Al Muhanna, Loulwa Faisal Al Saud, Nora Alaiban, Moudi Alsaud

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Searching For Authentic Cultural Engagement In The Classroom, James H. Lyle Jr.

Northwest Journal of Teacher Education

Many teachers in the current public education system in the United States do not fully consider the unique societal and cultural aspects of African American and Latinx learners. As a result, many teachers could benefit from developing skills that strengthen their understanding of authentic engagement, cultural competency, and cultural congruency to aid in implementing culturally relevant and sustaining pedagogical practices that benefit the diverse learning styles of these students. Additionally, some African American/Black teachers have adopted a standalone Eurocentric approach to teaching that could further alienate and disenfranchise students of Color. To address these issues, I describe and explain the …

Office Of Equity And Inclusion Newsletter - October 2024, Office Of Equity And Inclusion, East Tennessee State University

Office of Equity and Inclusion Newsletters

No abstract provided.

Empowering Entrepreneurial Evolution: A Beyond Founder Strategic Approach To Small Business Growth, D. Jared Knisley

USF Tampa Graduate Theses and Dissertations

Growing a business beyond its founder’s capacities and talents presents a challenging undertaking. When a founder is no longer involved or motivated to grow the business, firm decline is a likely outcome. Small businesses often have a deep and, at times, hindering reliance on their early founders for development. Therefore, a continuous engaging plan to advance entrepreneurial success is needed to grow a small business.

My research objective aims to find methods and designs, through academic literature and practitioner interviews, that transition leadership responsibilities and increase team empowerment within a small business, enabling these firms to continue growing as the …

Promoting Equity In Culturally Diverse Schools: A Literature Review Of Third Space Pedagogy, Sarah E. Harrison, Heidi Curtis

Northwest Journal of Teacher Education

The increasingly culturally diverse settings present within today’s P-12 schools necessitate improved pedagogical practices to develop more culturally inclusive and equitable learning environments. Third-space pedagogical practices demonstrate potential as an approach for increasing educational equity by promoting cultural hybridity among diverse students and stakeholders through negotiated sociocultural perspectives and interactions. This literature review summarizes recent scholarship surrounding third-space pedagogy, including discussions of how educators can foster third-space relationships and design third-space learning opportunities in diverse educational settings. In addition, lessons from COVID-19 third-space learning opportunities are discussed as a model for re-envisioning equitable instructional practices post-pandemic.

Social Comparison And Self-Determination In Luxury Consumption Motivations, Maria Petrescu, Jose Ribamar Siqueira, Costinel Dobre, Selima Ben Mrad, Anca-Milovan Ciuta, Aycan Kara

Publications

This study integrates social comparison theory and self-determination theory to examine the roles of escapism, conformity, and individual cultural values in shaping luxury brand attitudes. Concepts related to consumer upward and downward social comparison are complemented by aspects related to self-determination and autonomy. Drawing on survey data from the United States and Colombia, the research employs partial least squares structural equation modeling and fuzzy-set qualitative comparative analysis (fsQCA) to investigate the complex drivers of luxury consumption. The findings reveal that escapism and conformity, complementary motivations grounded in social comparison and self-determination theories, positively influence luxury brand attitudes. Furthermore, individual cultural …

The False Choice Between Digital Regulation And Innovation, Anu Bradford

Northwestern University Law Review

This Article challenges the common view that more stringent regulation of the digital economy inevitably compromises innovation and undermines technological progress. This view, vigorously advocated by the tech industry, has shaped the public discourse in the United States, where the country’s thriving tech economy is often associated with a staunch commitment to free markets. U.S. lawmakers have also traditionally embraced this perspective, which explains their hesitancy to regulate the tech industry to date. The European Union has chosen another path, regulating the digital economy with stringent data privacy, antitrust, content moderation, and other digital regulations designed to shape the evolution …

A Feedback Loop Of Exclusion: The Treatment Of Bilingualism In The Courtroom, Simone Stover

Northwestern University Law Review

In the 1991 case Hernandez v. New York, the United States Supreme Court characterized bilingualism as a race-neutral trait that can be used to exclude individuals from jury service. This Note proceeds by demonstrating how the current state of the law undermines the interests of bilingual individuals and then proposes a solution. Focusing specifically on Hispanic bilingual Spanish speakers, this Note first employs Professor Jennifer Lackey’s multi-directional credibility model to show that bilingual Spanish speakers suffer injustice in the courtroom due to both credibility deficits and excesses. Following this analysis, it proposes a possible solution to this issue: an …

Finding The Right Mentor & Maintaining The Relationship Through Key Conversations, Adebisi Alli, Ankita Sagar, Eliza Lo Chin, Paulina Awuah-Saadiq, Susan Thompson Hingle

Journal of Wellness

No abstract provided.

Cryo-Em Analysis Of Pseudomonas Phage Pa193 Structural Components, Stephano M. Iglesias, Chun-Feng Hou, Johnny Reid, Evan Schauer, Renae Geier, Angela Soriaga, Lucy Sim, Lucy Gao, Julian Whitelegge, Pierre Kyme, Deborah Birx, Sebastien Lemire, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

The World Health Organization has designated Pseudomonas aeruginosa as a critical pathogen for the development of new antimicrobials. Bacterial viruses, or bacteriophages, have been used in various clinical settings, commonly called phage therapy, to address this growing public health crisis. Here, we describe a high-resolution structural atlas of a therapeutic, contractile-tailed Pseudomonas phage, Pa193. We used bioinformatics, proteomics, and cryogenic electron microscopy single particle analysis to identify, annotate, and build atomic models for 21 distinct structural polypeptide chains forming the icosahedral capsid, neck, contractile tail, and baseplate. We identified a putative scaffolding protein stabilizing the interior of the capsid 5-fold …

Teacher Retention Challenges: What We Learned Before And After Covid-19, Brenda Morton, Edd., Joel Maresh Edd

Northwest Journal of Teacher Education

The COVID-19 pandemic exacerbated the already elevated stress levels among teachers, leading to contemplation of leaving the profession. As educators were compelled to transition to online teacher, they suddenly found themselves immersed in the households of their students, an entirely novel experience. This newfound proximity granted teachers insight into various aspects of the students’ lives, including family dynamics, home environments, levels of household stress, and the accessibility of essential resources. In addition to the teaching duties, educators were tasked with the development of online curricula, the acquisition of online learning resources, and providing support to parents and families during a …

Review Of “Social Entrepreneurship In India: Quarter Idealism And A Pound Of Pragmatism” By Madhukar Shukla (2020), Meena Raghunathan

Markets, Globalization & Development Review

The article is a review of ‘Social Entrepreneurship in India: Quarter Idealism and a Pound of Pragmatism’ by Madhukar Shukla. It summarizes and offers clarification and elaboration of key concepts covered in the book. These include the definition of social entrepreneurship, the taxonomy of social entrepreneurs, what characterizes them, various forms that such organizations may take, and whether social entrepreneurs are fundamentally different from other entrepreneurs or similar in many ways.

The review points out the value of the book for those in social development, argues that the book is for India as well as of universal interest, and …

Digital Twinning For Resilient Global Supply Chains: Three Case Studies, Gawon Yun, Douglas N. Hales, Leo Hong

Markets, Globalization & Development Review

Global supply chains have vulnerabilities, and these escalate in crisis times like pandemics or wars. Digital twinning of supply chains can provide early alerts and timely interventions. We examined three companies in different industries using Digital Twin (DT) technology to improve their supply chain performance. We found that while DT successfully enhanced performance indicators, the dollar and time costs were significant, creating barriers to wider DT adoption. We conclude by outlining the positives and negatives of implementing Digital Twins in global supply chains.