Digital Commons Network^™

Peptidases Are Potential Targets Of Copper(Ii)-1,10-Phenanthroline-5,6-Dione Complex, A Promising And Potent New Drug Against Trichomonas Vaginalis, Graziela Vargas Rigo, Fernando Gomes Cardoso, Matheus Menonca Pereira, Michael Devereux, Malachy Mccann, Andre L.S. Santos, Tiana Tasca

Articles

Trichomonas vaginalis is responsible for 156 million new cases per year worldwide. When present asymptomatically, the parasite can lead to serious complications, such as development of cervical and prostate cancer. As infection increases the acquisition and transmission of HIV, the control of trichomoniasis represents an important niche for the discovery and development of new antiparasitic molecules. This urogenital parasite synthesizes several molecules that allow the establishment and pathogenesis of infection. Among them, peptidases occupy key roles as virulence factors, and the inhibition of these enzymes has become an important mechanism for modulating pathogenesis. Based on these premises, our group recently …

Ecological Adaptation And Speciation In Chipmunks, Nathanael David Filer Herrera

Graduate Student Theses, Dissertations, & Professional Papers

Understanding how evolutionary and ecological mechanisms promote speciation and adaptation is one of the central challenges of evolutionary biology. Recent advancements in theoretical, methodological, and computational approaches now allow biologists to test long-standing questions regarding the evolutionary history of species. This includes the genomic underpinnings of reproductive barriers and adaptive phenotypes, and the contribution of ecology, geography, and demography in the generation and maintenance of biodiversity. While great strides have been made in understanding the genetic and ecological factors that underlie speciation and local adaptation, many open questions remain. My dissertation first seeks to address questions about how we define …

A Case Study On The Practice Of Carbon Offset Projects In Michigan: Forest Practitioners’ Perspectives, Zachary B. Hough Solomon

Dissertations, Master's Theses and Master's Reports

This report examines the practice of carbon offset programs on private nonindustrial forestlands in the state of Michigan ass. Previously, the state of Michigan provided technical assistance for enrollment in carbon offsets through the Michigan Working Forest Carbon Offset Program, but this program has now been discontinued. Currently, private companies and nongovernmental organizations are developing projects throughout the state with nonindustrial private landowners. This descriptive analysis in this case study examines the roles of different forest practitioners who are working on carbon offsets, including private consulting foresters and foresters within Michigan public agencies. I review the academic and grey literature …

Identification And Characterization Of Bacteriophages For Phage Cocktail Formulation Specific To Uropathogenic Escherichia Coli, Pattida Kongsomboonchoke

Chulalongkorn University Theses and Dissertations (Chula ETD)

Urinary tract infections (UTIs) are commonly found in elderlies, infants, hospitalized patients, and most women. UTIs are caused by a variety of pathogens with uropathogenic Escherichia coli (UPEC) is mostly prevalence. Even though UPEC can be treated with several antibiotics, the rapid emergence of multidrug resistant (MDR)-UPEC renders the antibiotic treatment no longer successful. Therapy using phages, which are bacterial viruses, has been considered but it is limited by bacterial resistance that develops during evolution. Fortunately, the suppression of phage resistance can be improved when used several phages as a cocktail. Here, I aim to formulate an efficient phage cocktail …

Design, Synthesis, And Biological Evaluation Of Darunavir Analogs As Hiv-1 Protease Inhibitors, Muhammad Asad Ur Rehman

Chulalongkorn University Theses and Dissertations (Chula ETD)

Darunavir, a potent inhibitor for HIV protease (PR) for the treatment of HIV infection, encounters limitations due to the emergence of multi-drug resistance HIV strains, imposing the development of darunavir analogs as new HIV protease inhibitors (PI) with enhanced efficacy. In this study, a combinatorial in silico method was used to at first design a several HIV-1 PI analogs with variations at key sites, P1' and P2', to improve the interactions with HIV-1 PR. Fifteen analogs with encouraging binding score were selected for synthesis and assessed for the inhibition activity of HIV-1 PR. The study demonstrated the effectiveness of P2' …

Covidanno, Covid-19 Annotation In Human, Yuzhou Feng, Mengyuan Yang, Zhiwei Fan, Weiling Zhao, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 19 (COVID-19), has caused a global health crisis. Despite ongoing efforts to treat patients, there is no universal prevention or cure available. One of the feasible approaches will be identifying the key genes from SARS-CoV-2-infected cells. SARS-CoV-2-infected in vitro model, allows easy control of the experimental conditions, obtaining reproducible results, and monitoring of infection progression. Currently, accumulating RNA-seq data from SARS-CoV-2 in vitro models urgently needs systematic translation and interpretation. To fill this gap, we built COVIDanno, COVID-19 annotation in humans, available at http://biomedbdc.wchscu.cn/COVIDanno/. The aim …

3pnmf-Mkl: A Non-Negative Matrix Factorization-Based Multiple Kernel Learning Method For Multi-Modal Data Integration And Its Application To Gene Signature Detection\, Saurav Mallik, Anasua Sarkar, Sagnik Nath, Ujjwal Maulik, Supantha Das, Soumen Kumar Pati, Soumadip Ghosh, Zhongming Zhao

Faculty, Staff and Student Publications

In this current era, biomedical big data handling is a challenging task. Interestingly, the integration of multi-modal data, followed by significant feature mining (gene signature detection), becomes a daunting task. Remembering this, here, we proposed a novel framework, namely, three-factor penalized, non-negative matrix factorization-based multiple kernel learning with soft margin hinge loss (3PNMF-MKL) for multi-modal data integration, followed by gene signature detection. In brief, limma, employing the empirical Bayes statistics, was initially applied to each individual molecular profile, and the statistically significant features were extracted, which was followed by the three-factor penalized non-negative matrix factorization method used for data/matrix fusion …

Harnessing The Potential Of Fibrous Polyester Composites Meant For Bioactive Medical Devices, Graciela Morales, Heriberto Rodríguez-Tobías, Victoria Padilla-Gainza, Karen Lozano, Daniel Grande

Mechanical Engineering Faculty Publications

Fibrous-based composite polyester mats have gained importance in the biomedical area due to their morphological characteristics and mechanical performance. These materials can be modified by incorporating different inorganic micro- or nano-particles, thus leading to promising potential applications as medical devices with antimicrobial and/or bioactive properties. In this regard, this chapter reports a compilation of different studies related to the development of sub-micron fibers based on two important polyesters for biomedical use, namely poly(3-hydroxybutyrate) and poly(lactic acid). Studies focus on fibers developed through hydrodynamic techniques, namely electrospinning, electrospraying, and centrifugal spinning. The incorporation of zinc oxide or hydroxyapatite on the polyester-based …

Computer-Based Interactive Project E-Book: A Guide For Genetic 1 Course To Enhance Biology Students’ Cognitive Learning Results, Hikmah Buroidah, Siti Zubaidah, Susriyati Mahanal, Azizul Ghofar Candra Wicaksono

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to develop a computer-based interactive Genetics project guide e-book to enhance undergraduate biology students’ cognitive learning outcomes. This development was carried out because there had been no available written guidebook for the Genetics project, which resulted in non-optimum project implementation. The content in the e-book consists of a description of material related to Drosophila melanogaster, descriptions and videos of general procedures, PjBL-based learning activities, and quizzes. Lee and Owen’s development model was used in this study which consisted of 4 stages, (1) multimedia need assessment and analysis; (2) multimedia instructional design; (3) multimedia development and implementation; and …

Antimalarial And Antimicrobial Activities Of Some Heteroleptic Metal(Ii) Complexes Of Sulfadiazine–Vitamin C: Synthesis And Spectroscopic Studies, Ikechukwu P. Ejidike, Mercy O. Bamigboye, Dorcas A. Fadare, Juliana B. Adetunji, Joshua A. Obaleye

Tanzania Journal of Science

Some new Ni(II), Zn(II), Co(II), Cu(II), and Cd(II) of mixed Sulphadiazine and Vitamin C complexes have been synthesized and characterized by different spectroscopic techniques such as FT-IR, elemental analysis, molar conductivity, and magnetic measurements. Both ligands used for this research work act as bidentate ligands towards the central metal ions coordinating through the nitrogen atoms of >C=N–, NH2 groups of Sulphadiazine and oxygen atoms of OH, CO groups of Vitamin C. Tetrahedral and square-planar geometries have been proposed for the complexes. The complexes are stable under atmospheric conditions. The ligands and their complexes were screened for antimicrobial activities against some …

Late-Stage Functionalization Through Click Chemistry Provides Glut5-Targeting Glycoconjugate As A Potential Pet Imaging Probe, Adelina Oronova, Marina Tanasova

Michigan Tech Publications, Part 1

The targeting of facilitative sugar transporters (GLUTs) has been utilized in the development of tools for diagnostics and therapy. The interest in this area is promoted by the phenomenon of alterations in cellular metabolic processes that are linked to multitudes of metabolic disorders and diseases. However, nonspecific targeting (e.g., glucose-transporting GLUTs) leads to a lack of disease detection efficiency. Among GLUTs, GLUT5 stands out as a prominent target for developing specific molecular tools due to its association with metabolic diseases, including cancer. This work reports a non-radiolabeled fluoride (19F) coumarin-based glycoconjugate of 2,5-anhydro-D-mannitol as a potential PET imaging probe that …

Ex Vivo Drug Sensitivity Correlates With Clinical Response And Supports Personalized Therapy In Pediatric Aml, Debbie C Strachan, Christine J Gu, Ryosuke Kita, Erica K Anderson, Michelle A Richardson, George Yam, Graham Pimm, Jordan Roselli, Alyssa Schweickert, Maci Terrell, Raushan Rashid, Alan K Gonzalez, Hailey H Oviedo, Michelle C Alozie, Tamilini Ilangovan, Andrea N Marcogliese, Hiroomi Tada, Marianne T Santaguida, Alexandra M Stevens

Faculty, Staff and Students Publications

Acute myeloid leukemia (AML) is a heterogeneous disease that accounts for ~20% of all childhood leukemias, and more than 40% of children with AML relapse within three years of diagnosis. Although recent efforts have focused on developing a precise medicine-based approach towards treating AML in adults, there remains a critical gap in therapies designed specifically for children. Here, we present ex vivo drug sensitivity profiles for children with de novo AML using an automated flow cytometry platform. Fresh diagnostic blood or bone marrow aspirate samples were screened for sensitivity in response to 78 dose conditions by measuring the reduction in …

Morphological And Anatomical Characterization Of Cymbopogon Citratus (Dc.) Stapf Cultivated In Egypt, Yasmine F. Madi, Meselhy R. Meselhy, El-Sayeda A. El-Kashoury, Mouchira A. Choucry

Bulletin of Faculty of Pharmacy Cairo University

Cymbopogon citratus (DC.) Stapf (family Poaceae) is a tropical lemon-scented perennial grass commonly used, fresh or dried, in food and herbal teas. This study revealed that C. citratus different organs are characterized by histological features distinctive to family Poaceae. Characteristic oil cells stained pink with Schiff′s reagent were noticed particularly in the leaf and culm. Scattered closed-type vascular bundles are observed in different organs. Graminaceous stomata and phytolith are restricted to the leaf blade, leaf sheath, and culm. C. citratus leaf is featured by its remarkable epidermal structure formed of long and short cells, bulliform cells, bundle sheath cells, as …

Isolation, Culture, And Immunophenotypic Analysis Of Bone Marrow Hspcs From Patients With Myelodysplastic Syndromes, Irene Ganan-Gomez, Karen Clise-Dwyer, Simona Colla

Faculty, Staff and Student Publications

Drug testing assays in hematopoietic stem and progenitor cells (HSPCs) are fundamental in biological studies of myelodysplastic syndromes (MDS) but have historically entailed a technical challenge. This protocol allows the efficient isolation of MDS HSPCs from bone marrow mononuclear cell fractions and their culturing with the support of stromal cells for improved maintenance during drug testing. Lastly, specific steps are given to quantify surviving cells and assess changes in the HSPC hierarchies.

For complete details on the use and execution of this protocol, please refer to Ganan-Gomez et al. (2022).

Understanding The Ahupua'a: Using Remote Sensing To Measure Upland Erosion And Evaluate Coral Reef Structure, Logan Kalaiwaipono Ellis

Theses and Dissertations

Under ever intensifying pressures from land use, climate change, and erosion, tropical islands are among the most vulnerable systems in the world. Terrestrial systems are weakened by intensifying land use patterns, the weakening of which is highlighted when high intensity rainfall events erode sediment and leads to sediment deposition on the marine system. The deposition of sediment on the marine system is a major stressor that can lead to weakened coral reefs and a decrease in marine resources commonly gathered for food. These interactions have led to the emergence of biocultural resource management strategies, one of which is the ahupua'a …

Étude Visant À Mieux Guider L’Évaluation Des Risques Des Travailleurs Exposés Aux Nanoparticules (Np) : Existe-T-Il Différentes Propriétés Inflammatoires Des Np Liées Au Sexe?, Marion Vanharen, Abdelaziz Saafane, Alexanne Léveillé, Thomas Mahbeer, Denis Girard

Rapports de recherche scientifique

Les nanotechnologies offrent un important potentiel d’exploitation dans des secteurs industriels variés, pour lequel les bénéfices financiers ne sont pas négligeables. À l’instar des provinces canadiennes et de nombreux pays industrialisés, le Québec voit un nombre grandissant de compagnies produisant des nanomatériaux et des nanoparticules (NP) se développer, sans oublier celles qui introduisent de plus en plus de NP dans leurs produits. Le nombre de travailleurs québécois œuvrant dans la fabrication et dans la synthèse des NP augmentera dans les années à venir. De plus, le nombre de travailleurs appelés à manipuler et à transformer des NP dans les domaines …

Bis-Indolyl Compounds And The Induction Of Apoptosis In T98g Glioblastoma Multiforme Cells, Margot C. Brown

Seton Hall University Dissertations and Theses (ETDs)

1,1-bis(3’idolyl)-1(aryl)methane compounds (BIM compounds) have been shown to have anti-cancer properties in colon cancer, bladder cancer, and leukemia cells. The purpose of this work was to determine if BIM compounds could be an effective treatment of glioblastoma multiforme. Sulforhodamine B (SRB) assays showed that 20µM of the BIM compounds could inhibit cellular proliferation of the T98G glioblastoma multiforme cell line over 72 hours. Then immunoblotting was used to analyze the molecular pathway induced by BIM compounds. An increase in the expression of both BAX and cleaved caspase 3 suggest BIM compounds activate programmed cell death, or apoptosis in glioblastoma cells. …

Epigenetic Basis Of Diabetic Vasculopathy, Theja Bhamidipati, Manishekhar Kumar, Sumit S. Verma, Sedat Kacar, Diamond Reese, Michelle M. Martinez, Malgorzata M. Kamocka, Kenneth W. Dunn, Chandan K. Sen, Kanhaiya Singh

Einstein Health Papers

Type 2 diabetes mellitus (T2DM) causes peripheral vascular disease because of which several blood-borne factors, including vital nutrients fail to reach the affected tissue. Tissue epigenome is sensitive to chronic hyperglycemia and is known to cause pathogenesis of micro- and macrovascular complications. These vascular complications of T2DM may perpetuate the onset of organ dysfunction. The burden of diabetes is primarily because of a wide range of complications of which nonhealing diabetic ulcers represent a major component. Thus, it is imperative that current research help recognize more effective methods for the diagnosis and management of early vascular injuries. This review addresses …

Wild/Feral Horses: The Great Debate Between Freedom And Capturing, Jolee Lamoreaux

Fall Student Research Symposium 2022

Wild Horses have been around for as long as anyone can remember. However, there has been a great debate that these horses are harmful to the environment and they need to be taken care of either by rehoming or slaughtering. This study aims to determine why people think these horses are harmful and what has been done to try and solve the issue. I conducted my research mostly by researching keywords and evaluating my search results to examine credible sources. The three major claims that I wanted to make sure I addressed in my paper were the history and background …

An Evaluation Of The Activity Of Prepared Zinc Nanoparticles With Extracted Alfalfa Plant In The Treatment Of Heavy Metals, Zainab Ridha Al-Bahadili, Abbas Ali Salih Al-Hamdani, Farqad Abdullah Rashid, Labeeb Ahmed Al-Zubaidi, Suha Mohamed Ibrahim

Baghdad Science Journal

The alfalfa plant, after harvesting, was washed, dried, and grinded to get fine powder used in water treatment. We used the alfalfa plant with ethanol to make the alcoholic extract characterized by using (GC-Mass, FTIR, and UV) spectroscopy to determine active compounds. Alcoholic extract was used to prepare zinc nanoparticles. We characterized Zinc nanoparticles using (FTIR, UV, SEM, EDX Zeta potential, XRD, AFM). Zinc nanoparticle with Alfalfa extract and alfalfa powder were used in the treatment of water polluted with inorganic elements such as Cr, Mn, Fe, Cu, Cd, Ag by (Batch processing). The batch process with using alfalfa powder …

Synthesis, Identification, Theoretical Study, And Effect Of The New Heterocyclic System From Ciprofloxacin Derivatives On The Activity Of Some Liver Enzymes, Amaal S. Sadiq, Zahraa T. Khudhair, Selvana A. Yousif, Wasan A. R. Mahmood

Baghdad Science Journal

The target of this study was to synthesize several new Ciprofloxacin drug analogs by providing a nucleophilic substitution procedure that provides new functionality at the carboxylic group location. The analogs were synthesized, designed, and characterized by 1HNMR, and FTIR. The synthetic path began from the reaction of ciprofloxacin drug with morpholine to give compound[B], ciprofloxacin derivative was linked with a variety of primary and secondary amines to give compounds[B1-B9]. The above-mentioned prepared compounds [B3 and B5] were applied to liver enzymes, and the increase in the activity of these enzymes was observed. In addition, a theoretical study was conducted to …

Probing Conformational Landscapes And Mechanisms Of Allosteric Communication In The Functional States Of The Abl Kinase Domain Using Multiscale Simulations And Network-Based Mutational Profiling Of Allosteric Residue Potentials, Keerthi Krishnan, Hao Tian, Peng Tao, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

In the current study, multiscale simulation approaches and dynamic network methods are employed to examine the dynamic and energetic details of conformational landscapes and allosteric interactions in the ABL kinase domain that determine the kinase functions. Using a plethora of synergistic computational approaches, we elucidate how conformational transitions between the active and inactive ABL states can employ allosteric regulatory switches to modulate intramolecular communication networks between the ATP site, the substrate binding region, and the allosteric binding pocket. A perturbation-based network approach that implements mutational profiling of allosteric residue propensities and communications in the ABL states is proposed. Consistent with …

Expression Of The Preadipocyte Marker Zfp423 Is Dysregulated Between Well-Differentiated And Dedifferentiated Liposarcoma, Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau, Z. Elizabeth Floyd

Division of Basic Science Faculty Publications

Background: Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential. Dedifferentiated liposarcoma (DDLPS) is highly aggressive and has an overall 5-year survival rate of 30% as compared to 90% for well-differentiated liposarcoma (WDLPS). This discrepancy may be connected to their potential to form adipocytes, where WDLPS is adipogenic but DDLPS is adipogenic-impaired. Normal adipogenesis requires Zinc Finger Protein 423 (ZFP423), a transcriptional coregulator of Perixosome Proliferator Activated Receptor gamma (PPARG2) mRNA expression that defines committed preadipocytes. Expression of ZFP423 in preadipocytes is promoted by Seven-In-Absentia Homolog …

Labrad : Vol 47, Issue 2 - December 2022, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• From the Editor’s Desk
• Case Quiz
• Contrast Enhanced Spectral Mammography Clinical Usefulness of Biochemical Parameters in Prenatal Diagnosis of Down Syndrome In First and Second Trimester
• The Science of Efficiency in a Clinical Laboratory
• Updates in new WHO Blue Book
• Monkeypox vs. COVID-19
• From the Diary of a Researcher- Notes on Understanding Beta-Thalassemia and Metabolic Bone Disease
• Significance of Audit in a Clinical Laboratory
• Microsatellite Instability (MSI) Testing
• Pre-Analytical Variables Affecting Coagulation Testing
• Grading of Soft Tissue Sarcomas
• Recent Updates in 2022 WHO Classification of Thyroid Neoplasms
• MMR and MSI Testing in Malignancies
• Transforming Pedagogical Framework of Pathology through Social …

Optogenetic Heart Pacing And Heart Arrest In Drosophila Melanogaster Using Integrated Ocm Imaging And Light Stimulation System, Yuxuan Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Optogenetics has been widely applied to cardiovascular research using different models. Among them, Drosophila melanogaster (fruit fly) outstands for its similarity of human genes for disease modeling and short life cycle for rapid screening to analyze genetic mechanisms of heart disease. However, most of the current models only allow either activation or inhibition of the heartbeat, which is not sufficient to model complex arrhythmia. Our lab developed a novel Drosophila transgenic model based on a double transgenic line containing two light-sensitive genes, Channelrhodopsin-2 (ChR2) and Halorhodopsin2.0 (NpHR2.0), that enable dual-directional control of the heartbeat rhythm. Real-time optical control of the …

Isolation Of Drug-Sensitive Eimeria Species From Wild Turkey Feces And Development Of A Model Bioshuttle Program For Eimeria Meleagrimitis For Domestic Turkeys, Maria Carolina Trujillo Peralta

Graduate Theses and Dissertations

The objective of this thesis was to determine the anticoccidial profile of Eimeria spp. derived from wild turkeys. These drug-sensitive Eimeria spp. have potential to be used as vaccine candidates to control coccidiosis in commercial turkeys. Chapter two consists of a brief literature review focused on coccidiosis in turkeys. Chapter three addresses the methodologies utilized to isolate, recover, and speciate Eimeria recovered from wild turkey feces in the eastern two-thirds of the United States. From this, we successfully obtained single oocyst-derived stocks for E. meleagrimitis, E. dispersa, E. meleagridis, E. gallopavonis, and E. adenoeides. Chapter four describes the experiment conducted …

Fabrication And Characterization Of Force Spun Polymeric Nanofiber For Drug Delivery And Tissue Engineering Applications, Salahuddin Ahmed

Theses and Dissertations

This study focuses on the development and characterization of polymeric nanofiber for drug delivery and tissue engineering applications. In this study, poly(lactic-co-glycolic) acid (PLGA), Poly-vinyl alcohol (PVA), and Pullulan(PL) were used as the base polymers to develop the nanofiber. Bioactive components Oleanolic acid(OA), Oxymatrine(OM), and Salvianolic Acid(SA) were incorporated in PLGA, PVA, and PL, respectively, via solution mixing. The nano fiber systems were developed using the Forcespinning® method. Morphological, thermo-physical, and biological properties of the fiber mats were analyzed. The composite fiber system containing OA showed a very high drug loading efficiency. The composite fiber system containing high concentration of …

Synthesis Of Bioactive Heterocycles, Shaila Akter Shetu

Theses and Dissertations

The Discovery of a variety of heterocyclic drugs for the treatment of cancer and other diseases (e.g, neglected tropical diseases) is a medical breakthrough and inspiring for the research community as a whole. A wide range of natural, semi-synthetic, and synthetic anticancer drugs are synthesized using various methods. Among them, β -lactams stand out as a novel class of antibiotics that has different types of biological as well as anti-cancer properties. β -lactam has become a premier and active research subject towards the development of revolutionary anti-cancer drugs. In recent years, a large amount of investigations have been done to …

Spectroscopic Study Of Bi5ti3feo15 Aurivillius Compound For Multifunctional Applications, Mariana Castellanos

Open Access Theses & Dissertations

No abstract provided.

Development And Characterization Of Forcespinning® Mesquite Gum Nanofibers, Cristobal Rodriguez, Victoria Padilla, Karen Lozano, Alexa Villarreal, Luis A. Materon, Robert Gilkerson

Mechanical Engineering Faculty Publications

In this study, nanofibers incorporating Prosopis glandulosa mesquite gum (MG) exudate combined with biodegradable polymers, pullulan (PL) and chitosan (CH), were produced via the Forcespinning® technique. The nonwoven composite membranes were characterized via scanning electron microscopy followed by thermogravimetric and Fourier-transform infrared spectroscopy analysis. MG nanofiber composites comprised long, continuous fibers with an average fiber diameter of 523 ± 180 nm and 760 ± 225 nm for 18.1 and 28 wt% of MG, respectively. These composite membranes were water-stable after crosslinking via heat treatment with a ∼3 % water absorption capacity, and demonstrated a thermal capability with an increasing …