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Releasement And Seduction: Heidegger And Baudrillard On The Preservation Of Illusion In The Epoch Of Obscenity, Marc Oliver D. Pasco Jan 2021

Releasement And Seduction: Heidegger And Baudrillard On The Preservation Of Illusion In The Epoch Of Obscenity, Marc Oliver D. Pasco

Philosophy Department Faculty Publications

This work interfaces the philosophies of Jean Baudrillard and Martin Heidegger. It hopes to contribute to both Heideggerian and Baudrillardian scholarship by employing Baudrillardian ideas in more effectively describing the historical happening of the so-called withdrawal of Being from man, which preoccupied much of Heidegger’s body of work. The work argues that by re-visiting an earlier idea of Baudrillard, which he termed as seduction, one finds a possible way of navigating the obscenity of the current epoch of Being. Akin to Heidegger’s idea of Gelassenheit or releasement, Baudrillard’s concept of seduction invites one to allow the real to once again …

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Development Of Chemical Methods For Oligonucleotide Purification, Paramagnetic Labeling And Synthesis Of Dna-Based Advanced Materials, Muhan He Jan 2021

Development Of Chemical Methods For Oligonucleotide Purification, Paramagnetic Labeling And Synthesis Of Dna-Based Advanced Materials, Muhan He

Legacy Theses & Dissertations (2009 - 2024)

This thesis describes a chemical method for alternative oligonucleotide purification that is non-chromatographic and gel-free and allows to routinely synthesize and purify long functional RNA strands. The purification of long RNAs is based on the bio-orthogonal inverse electron demand Diels-Alder (IEDDA) chemistry between trans-cyclooctene (TCO) and tetrazine (Tz). Target oligonucleotide strands are selectively tagged with Tz and can be captured and purified from the failure sequences with immobilized TCO. RNA strands are synthesized on solid support through a photolabile linker to avoid the loss of Tz tag. Purity of the isolated oligonucleotides was evaluated using gel electrophoresis, HPLC and mass …

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Evaluation Of The Effects Of Temperature, Light, And Uv-C Radiation On Hsp70aexpression In Chlamydomonas Reinhardtii, Tuba Sevgi̇, Eli̇f Demi̇rkan Jan 2021

Evaluation Of The Effects Of Temperature, Light, And Uv-C Radiation On Hsp70aexpression In Chlamydomonas Reinhardtii, Tuba Sevgi̇, Eli̇f Demi̇rkan

Turkish Journal of Botany

In this study, various physical parameters (temperature, light intensity and UV-C radiation) which could be effective in heat shock response on C.reinhardtii by using molecular tools were investigated. In total, 256 transformants were obtained, among them, 160 transformants had continuous expression while 96 of them had heat-inducible expression. In these transformants, arylsulfatase activities were detected qualitatively and quantitatively. The best two transformants were selected and used in studies. To determine the effect of temperature, the cells were shifted from 23 °C to 35 °C, 37 °C, 40 °C and 42 °C. The heat shock response was induced at all temperatures. …

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Altered Water Relations, Selective Nutrient Uptake, And Reduced Na+ Flux Makehalopeplis Perfoliata An Obligate Halophyte, Sarwat Ghulam Rasool, Muhammad Zaheer Ahmed, Abdul Hameed, Bilquees Gul Jan 2021

Altered Water Relations, Selective Nutrient Uptake, And Reduced Na+ Flux Makehalopeplis Perfoliata An Obligate Halophyte, Sarwat Ghulam Rasool, Muhammad Zaheer Ahmed, Abdul Hameed, Bilquees Gul

Turkish Journal of Botany

Halopeplis perfoliata, a succulent halophyte of coastal marshy habitats, was grown in a greenhouse to study its adaptive responses in terms of growth, osmoregulation, and N-metabolism following one-month exposure to salinity (0, 150, 300, and 600 mmol L-1 NaCl). Biomass was optimal in 150 mmol L-1 NaCl with unaltered malondialdehyde (MDA) levels. On the other hand, biomass remained comparable to non-saline control with some increase in MDA in 300 and 600 mmol L-1 NaCl. Osmotic potential (?S ) was maintained up to 300 mmol L-1 NaCl that correlated with an increase in succulence (SC) and lower water deficit (WD), whereas …

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The Intersection Between Multi-Voiced Narratives And First-Person Narratives Of War Fiction: Epistemology And The Meaning Of War, Prashant Patel Jan 2021

The Intersection Between Multi-Voiced Narratives And First-Person Narratives Of War Fiction: Epistemology And The Meaning Of War, Prashant Patel

Electronic Theses and Dissertations, 2020-2023

The topic for this project concerns a critical rhetorical analysis of the correlation between texts of first-person narratives and multi-voiced narratives of the Vietnam War (1965-1975) and the American invasion of Iraq (2003-2011). Moreover, this project establishes a correlation between the textual design in these novels and concepts of epistemology that reside in the Western cannon of rhetorical theory. The theoretical framework that is incorporated within this study extracts concepts of (t)ruth from philosophical works such as Michel Foucault's Birth of the Clinic and Friedrich Nietzsche's On Truth and In a Nonmoral Sense. In comparison, I examine the concepts and …

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Crispr Systems For Covid-19 Diagnosis, Hossein Rahimi, Marziyeh Salehiabar, Murat Barsbay, Mohammadreza Ghaffarlou, Taras Kavetskyy, Ali Sharafi, Soodabeh Davaran, Subhash C. Chauhan, Hossein Danafar, Murali M. Yallapu Jan 2021

Crispr Systems For Covid-19 Diagnosis, Hossein Rahimi, Marziyeh Salehiabar, Murat Barsbay, Mohammadreza Ghaffarlou, Taras Kavetskyy, Ali Sharafi, Soodabeh Davaran, Subhash C. Chauhan, Hossein Danafar, Murali M. Yallapu

School of Medicine Publications

The emergence of the new coronavirus 2019 (COVID-19) was first seen in December 2019, which has spread rapidly and become a global pandemic. The number of cases of COVID-19 and its associated mortality have raised serious concerns worldwide. Early diagnosis of viral infection undoubtedly allows rapid intervention, disease management, and substantial control of the rapid spread of the disease. Currently, the standard approach for COVID-19 diagnosis globally is the RTqPCR test; however, the limited access to kits and associated reagents, the need for specialized lab equipment, and the need for highly skilled personnel has led to a detection slowdown. Recently, …

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Glycinergic Axonal Inhibition Subserves Acute Spatial Sensitivity To Sudden Increases In Sound Intensity, T. P. Franken, B. J. Bondy, D. B. Haimes, Joshua H. Goldwyn, N. L. Golding, P. H. Smith, P. X. Joris Jan 2021

Glycinergic Axonal Inhibition Subserves Acute Spatial Sensitivity To Sudden Increases In Sound Intensity, T. P. Franken, B. J. Bondy, D. B. Haimes, Joshua H. Goldwyn, N. L. Golding, P. H. Smith, P. X. Joris

Mathematics & Statistics Faculty Works

Locomotion generates adventitious sounds which enable detection and localization of predators and prey. Such sounds contain brisk changes or transients in amplitude. We investigated the hypothesis that ill-understood temporal specializations in binaural circuits subserve lateralization of such sound transients, based on different time of arrival at the ears (interaural time differences, ITDs). We find that Lateral Superior Olive (LSO) neurons show exquisite ITD-sensitivity, reflecting extreme precision and reliability of excitatory and inhibitory postsynaptic potentials, in contrast to Medial Superior Olive neurons, traditionally viewed as the ultimate ITD-detectors. In vivo, inhibition blocks LSO excitation over an extremely short window, which, in …

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1969 March, Memphis State University Bulletin Jan 2021

1969 March, Memphis State University Bulletin

Bulletins

Vol. 58, No. 2 of the Memphis State University bulletin containing The Graduate School catalog for 1969-70, 1969 March.

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1970 March, Memphis State University Bulletin Jan 2021

1970 March, Memphis State University Bulletin

Bulletins

Vol. 59, No. 2 of the Memphis State University bulletin containing the graduate catalog for 1970-71, 1970 March.

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1971 March, Memphis State University Bulletin Jan 2021

1971 March, Memphis State University Bulletin

Bulletins

Vol. 61, No. 2 of the Memphis State University bulletin containing the graduate catalog for 1971-72, 1971 March

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1972 March, Memphis State University Bulletin Jan 2021

1972 March, Memphis State University Bulletin

Bulletins

Vol. 61, No. 2 of the Memphis State University bulletin containing the graduate catalog for 1972-73, 1972 March

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Alkylation Of Cyclic Enol Ethers With Trichloroacetimidates, Harrison Higgins Jan 2021

Alkylation Of Cyclic Enol Ethers With Trichloroacetimidates, Harrison Higgins

Renée Crown University Honors Thesis Projects - All

No abstract provided.

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Biocompatible And Multifunctional Trityl Spin Probes For Electron Paramagnetic Resonance Spectroscopy, Teresa D. Gluth Jan 2021

Biocompatible And Multifunctional Trityl Spin Probes For Electron Paramagnetic Resonance Spectroscopy, Teresa D. Gluth

Graduate Theses, Dissertations, and Problem Reports (ETD)

The primary objective of my thesis was to develop and utilize a biocompatible multifunctional trityl spin probe for concurrent measurement of pO2, pHe, and [Pi] in vivo by electron paramagnetic resonance (EPR) spectroscopy (Chapter 2). My first goal was to synthesize the proposed probe we are terming HOPE71. Secondly, HOPE71 was characterized by X-band and L-band EPR spectroscopy. Next, the biocompatibility of HOPE71 was assessed through an albumin binding test, cytotoxicity assays, and in vivo intravenous tolerance. Then, the use of HOPE71 to measure the target parameters was demonstrated in a breast cancer …

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Co-Teaching Practices Of General And Special Educators In Secondary Science Classrooms, Samantha Jolene Ringl Jan 2021

Co-Teaching Practices Of General And Special Educators In Secondary Science Classrooms, Samantha Jolene Ringl

Theses and Dissertations--Education Sciences

The purpose of this study was to establish current levels of co-teaching implementation and to explore teachers’ perceptions of co-teaching and co-teacher relationships. This study also examined whether there is a relationship between teachers’ perception of their co-teaching relationship and their perception of co-teaching implementation in their classrooms. Analysis revealed that teachers generally have positive perceptions of their co-teaching partners and relationships, and these perceptions did not significantly differ between science teachers and special educators. However, this study found that teachers are not regularly planning lessons together, sharing the workload in the classroom, or choosing co-teaching models together. This study …

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Sample Mislabeling Detection And Correction In Bioinformatics Experimental Data, Soon Jye Kho Jan 2021

Sample Mislabeling Detection And Correction In Bioinformatics Experimental Data, Soon Jye Kho

Browse all Theses and Dissertations

Sample mislabeling or incorrect annotation has been a long-standing problem in biomedical research and contributes to irreproducible results and invalid conclusions. These problems are especially prevalent in multi-omics studies in which a large set of biological samples are characterized by multiple types of omics platforms at different times or different labs. While multi-omics studies have demonstrated tremendous value in understanding disease biology and improving patient outcomes, the complexity of these studies may increase opportunities for human error. Fortunately, the interrelated nature of the data collected in multi-omics studies can be exploited to facilitate the identification and, in some cases, correction …

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Evaluation Of Somatic Mutations In Solid Metastatic Pan-Cancer Patients, Moom R. Roosan, Isa Mambetsariev, Rebecca Pharaon, Jeremy Fricke, Angel R. Baroz, Joseph Chao, Chen Chen, Mohd W. Nasser, Ramakanth C. Venkata, Maneesh Jain, Lynette M. Smith, Susan E. Yost, Karen L. Reckamp, Raju Pillai, Leonidas Arvanitis, Michelle Afkhami, Edward W. Wang, Vincent Chung, Mihaela Cristea, Marwan Fakih, Marianna Koczywas, Erminia Massarelli, Joanne Mortimer, Yuan Yuan, Surinder K. Batra, Sumanta Pal, Ravi Salgia Jan 2021

Evaluation Of Somatic Mutations In Solid Metastatic Pan-Cancer Patients, Moom R. Roosan, Isa Mambetsariev, Rebecca Pharaon, Jeremy Fricke, Angel R. Baroz, Joseph Chao, Chen Chen, Mohd W. Nasser, Ramakanth C. Venkata, Maneesh Jain, Lynette M. Smith, Susan E. Yost, Karen L. Reckamp, Raju Pillai, Leonidas Arvanitis, Michelle Afkhami, Edward W. Wang, Vincent Chung, Mihaela Cristea, Marwan Fakih, Marianna Koczywas, Erminia Massarelli, Joanne Mortimer, Yuan Yuan, Surinder K. Batra, Sumanta Pal, Ravi Salgia

Journal Articles: Biochemistry & Molecular Biology

Metastasis continues to be the primary cause of all cancer-related deaths despite the recent advancements in cancer treatments. To evaluate the role of mutations in overall survival (OS) and treatment outcomes, we analyzed 957 metastatic patients with seven major cancer types who had available molecular testing results with a FoundationOne CDx® panel. The most prevalent genes with somatic mutations were TP53, KRAS, APC, and LRP1B. In this analysis, these genes had mutation frequencies higher than in publicly available datasets. We identified that the somatic mutations were seven mutually exclusive gene pairs and an additional fifty-two co-occurring gene pairs. Mutations …

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Harmonious Disturbance: Pushing The Boundaries Of Communicology In The Classroom And Beyond, Olivia Dugenet Jan 2021

Harmonious Disturbance: Pushing The Boundaries Of Communicology In The Classroom And Beyond, Olivia Dugenet

EWU Masters Thesis Collection

No abstract provided.

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An Evaluation Of The Social Perceptions And Biological Efficacy Of Unmanned Aircraft Systems For Avian-Agriculture Conflict, Mallory Gyovai White Jan 2021

An Evaluation Of The Social Perceptions And Biological Efficacy Of Unmanned Aircraft Systems For Avian-Agriculture Conflict, Mallory Gyovai White

Biological Sciences

North Dakota sunflower producers face a dilemma when it comes to blackbirds (Icteridae). Migrating flocks produce localized damage to production, which results in some farmers with no bird issues, while others face total economic losses. A dynamic and humane crop protection tool is necessary to reduce blackbird damage in this broad-scale agriculture setting, as damage is actively occurring, while considering the protected status of blackbirds. This study examined a novel tool, unmanned aircraft systems (hereafter, UAS), through the lens of a social evaluation of farmers’ opinions and the biological impact on blackbird flock behavior. Farmers were very willing to allow …

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Biochemical And Cellular Characterization Of Replication Factor A (Rfa) During Meiosis And The Dna Damage Response In Saccharomyces Cerevisiae, Angela Marie Adsero Jan 2021

Biochemical And Cellular Characterization Of Replication Factor A (Rfa) During Meiosis And The Dna Damage Response In Saccharomyces Cerevisiae, Angela Marie Adsero

Cellular and Molecular Biology

Replication Factor A (RFA) is an essential heterotrimeric single-stranded DNA (ssDNA) binding complex, comprised of Rfa1, Rfa2, and Rfa3 in Saccharomyces cerevisiae. RFA is required for DNA replication, repair, recombination, and cell cycle regulation. RFA acts as a sensor of ssDNA, a common intermediate of these processes, and coordinates these processes through recruitment of proteins. For example, during the DNA damage response (DDR), RFA-coated ssDNA is necessary for the recruitment and activation of the sensor kinase Mec1. Additional checkpoint proteins, also recruited by RFA, are necessary for the downstream recruitment and activation of the effector kinase Rad53 that ultimately leads …

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Harnessing Acoustic Streaming For Bioanalysis In Microfluidics, Xiaojun Li Jan 2021

Harnessing Acoustic Streaming For Bioanalysis In Microfluidics, Xiaojun Li

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the past few decades, microfluidic technology has been developed rapidly in both fabrication methods and multifunctionality integrations, making it a powerful tool for a wider variety of biological applications. The device fabrication method has expanded from conventional polymer-based micro devices to 3D-printed micro devices, and allows multiple functions such as electric, optic, magnetic and acoustic to be integrated on a single platform. This dissertation focuses on method development of acoustic streaming-based microfluidics in bioanalysis such as immunoassay, enzyme kinetics and DNA fragmentation analysis. In this dissertation, a micromixer was developed based on acoustic streaming generated from sharp-edge structure vibration …

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A First Flight In North Carolina—But Not At Kitty Hawk, Robert J. Wright Jan 2021

A First Flight In North Carolina—But Not At Kitty Hawk, Robert J. Wright

Department of Entomology: Faculty Publications

The southern corn billbug is a univoltine insect most common in the Coastal Plains region of North Carolina, Virginia, Georgia, and South Carolina. However, this insect can also be found in the midwestern U.S. (Van Duyn and Wright 1999). Early in the growing season, the adults can be found feeding at the base of corn plants—typically with their head pointed downward (Fig. 1)—by inserting their beak into the base of the plant. They can kill or stunt seedlings or injure the developing leaves inside the plant, causing twisted leaves as they emerge or a series of small holes across the …

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Synthesis Of Nest Predation Impacts Of Common Ravens On Sensitive Avian Species, Peter S. Coates, William C. Webb, Seth J. Dettenmaier, Seth M. Harju, David J. Delehanty Jan 2021

Synthesis Of Nest Predation Impacts Of Common Ravens On Sensitive Avian Species, Peter S. Coates, William C. Webb, Seth J. Dettenmaier, Seth M. Harju, David J. Delehanty

Human–Wildlife Interactions

Decades of mounting scientific evidence have revealed that common raven (Corvus corax; raven) population numbers have been increasing across nearly all regions of their geographic range in North America. Concomitantly, numerous native wildlife species have experienced elevated predation rates from ravens as populations have increased and expanded their range. Managers are concerned that increased raven predation of many threatened and endangered avian species in the U.S. and Canada during nesting periods may be hampering species recovery. We explored the literature to aggregate existing knowledge and evaluate the impacts of raven predation on nests and young of sensitive avian …

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The Undergraduate Spectrum 2021, Saint Mary's College Of California Jan 2021

The Undergraduate Spectrum 2021, Saint Mary's College Of California

The Undergraduate Spectrum

No abstract provided.

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Co-Distribution Of Ambient Light At Night And Incidence Of Human Cancers And Covid-19, Yidan Meng Jan 2021

Co-Distribution Of Ambient Light At Night And Incidence Of Human Cancers And Covid-19, Yidan Meng

Public Health Theses

Introduction and BackgroundThere are increasing concerns about the effects of artificial lights on human health, including hormone-related disease and immune functions. In January 2020, the outbreak of COVID-19 disrupted everyone’s life, and people who infected have various severity. Thus, we want to analyze whether people exposed to different ambient light at night (LAN) levels make them more susceptible to COVID-19 for our summer research. Besides the effects of LAN on immune functions, we also discussed the association of LAN and multiple cancers in seven states of Northeastern U.S. We used similar statistical and geographic analysis methods and separate them into …

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Development Of Analytical Methods For Analysis Of Glycosaminoglycans And Their Mimetics In Human Plasma, Rawan M. Fayyad Jan 2021

Development Of Analytical Methods For Analysis Of Glycosaminoglycans And Their Mimetics In Human Plasma, Rawan M. Fayyad

Theses and Dissertations

Glycosaminoglycans (GAGs) are linear, polydisperse polysaccharides consisting of alternating amino sugars and either a uronic acid or galactose residue. They are ubiquitous components of the extracellular matrix and are present on cell surfaces and in basement membranes. GAGs are highly negatively charged as a result of many sulfate and carboxylic acid groups, and are extremely heterogeneous in both their structure and in their physicochemical properties. This complexity in structure is attributed to the alterations in residue types, glycosidic bond linkage, sulfation levels, sulfation positions, and chain lengths during biosynthesis. GAGs interact with a wide number of proteins and modulate various …

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Antioxidant Activity Of Thunbergia Laurifolia Lindl. Ethanolic Extract In Keratinocytes, Buakotchaphan Jirabanjerdsiri Jan 2021

Antioxidant Activity Of Thunbergia Laurifolia Lindl. Ethanolic Extract In Keratinocytes, Buakotchaphan Jirabanjerdsiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Fine particulate matter (PM2.5) can cause skin damage through the induction of oxidative stress in epidermis. Antioxidants help counteract with cellular oxidant species and maintain cell homeostasis. This study aims to examine the protective effect of Thunbergia laurifolia lindl. ethanolic extract on PM2.5-mediated oxidative stress in epidermal keratinocytes. High-performance liquid chromatography with diode array detection was conducted for quantitative analysis of rosmarinic acid content in the extract. Cell viability was detected by the 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide assay. Intracellular ROS was monitored using 2’,7’-Dichlorodihydrofluorescein diacetate. Proteins related to p62-Keap1-Nrf2 signaling pathway were examined by western blot analysis. Expressions of Nrf2 and p62 …

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Α-Glucosidase Inhibitors From Dendrobium Delacourii, Dendrobium Gibsonii And Aerides Multiflora, May Thazin Thant Jan 2021

Α-Glucosidase Inhibitors From Dendrobium Delacourii, Dendrobium Gibsonii And Aerides Multiflora, May Thazin Thant

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this study, three plants from the Orchidaceae family, i.e., Dendrobium delacourii, Dendrobium gibsonii, and Aerides multiflora, were investigated for their chemical constituents and α-glucosidase inhibitory activities. A total of thirty compounds were isolated and structurally characterized. Eleven known compounds were identified from Dendrobium delacourii, including hircinol, ephemeranthoquinone, densiflorol B, moscatin, 4,9-dimethoxy-2,5-phenanthrenediol, gigantol, batatasin III, lusianthridin, 4,4',7,7'-tetrahydroxy-2,2'-dimethoxy-9,9',10,10'-tetrahydro-1,1'-biphenanthrene, phoyunnanin E, and phoyunnanin C. Two new compounds, i.e., dihydrodengibsinin and dendrogibsol, were isolated from Dendrobium gibsonii, along with seven known compounds including ephemeranthol A, dengibsinin, nobilone, aloifol I, lusianthridin, denchrysan A, and 4-methoxy-9H-fluorene-2,5,9-triol. Four new compounds, i.e., aerimultins A-C and dihydrosinapyl dihydroferulate, …

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Lipase Inhibitors From Dendrobium Senile, Myat Pann Phyu Jan 2021

Lipase Inhibitors From Dendrobium Senile, Myat Pann Phyu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Obesity is characterized as an abnormal lipid metabolism due the imbalance between the energy intake and output. Pancreatic lipase is secreted by the pancreas and plays an important role in the digestion and absorption of lipids in the small intestine. Inhibition of pancreatic lipase enzyme can reduce dietary fat absorption which will lead to loss of weight and finally result in hypocholesterolemia and hypoglycemia. From the whole plant of Dendrobium senile, a new phenanthrene derivative was isolated, together with seven known compounds, including 2,5,7-trihydroxy-4-methoxyphenanthrene (1), moscatin (2), 2,5-dihydroxy-4,9-dimethoxyphenanthrene (3), moscatilin (4), aloifol I (5), 4,4ʹ,8,8ʹ-tetramethoxy[1,1ʹ-biphenanthrene]-2,2ʹ,7,7ʹ-tetrol (6), 2,2ʹ,7,7ʹ-tetrahydroxy-4,4ʹ-dimethoxy-1,1ʹ-biphenanthrene (7) and bleformin …

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Rational Design Of Small Molecule Disruptors Of Protein-Protein Interactions: Pd-1/Pd-L1; C-Myc, Arid4b, Samuel Ofori Jan 2021

Rational Design Of Small Molecule Disruptors Of Protein-Protein Interactions: Pd-1/Pd-L1; C-Myc, Arid4b, Samuel Ofori

Theses and Dissertations--Chemistry

Protein-protein interactions (PPIs) are vital to many biological processes, including gene expression, and immune reactions to pathogens. There are approximately 650,000 PPIs in humans with pertinent physiological functions. Aberrant expression of PPIs lead to improper function and contribute to a plethora of disease conditions including cancer. Thus, PPIs represent an enormous target space for drug discovery and chemical probes. Direct targeting of clinically relevant PPIs with small molecules remains an unmet medical need. Development of small-molecule inhibitors of PPIs is a challenging enterprise and in most cases considered undruggable due to large protein surfaces, lack of deep binding pockets and …

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Design, Synthesis, And Anticancer Properties Of Ru(Ii) Complexes With Organometallic, “Expanded” Bipyridine, And O,O’-Chelating Ligands, Raphael Ryan Jan 2021

Design, Synthesis, And Anticancer Properties Of Ru(Ii) Complexes With Organometallic, “Expanded” Bipyridine, And O,O’-Chelating Ligands, Raphael Ryan

Theses and Dissertations--Chemistry

Cancer is a worldwide public health crisis that requires new and improved drugs to be developed to extend survival rates and improve quality of life for the patient. Platinum-based drugs are used in approximately 50% of cancer treatment regimens. These drugs are highly effective in many kinds of cancer; however, cancers can develop platinum resistance and these drugs have troubling side effects that reduced their use and efficacy. To overcome these disadvantages, many other metals have been studied for their anticancer properties. Notably, the anticancer properties of ruthenium-based agents have drawn considerable attention with multiple ruthenium complexes entering clinical trials. …

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