Digital Commons Network^™

High-Quality Mouse Reference Genomes Reveal The Structural Complexity Of The Murine Protein-Coding Landscape., Mohab Helmy, Jin U Li, Xinyu F Yan, Rachel K Meade, Elizabeth Anderson, Patrick B Chen, Anne M Czechanski, Tomás Di Domenico, Jonathan Flint, Erik Garrison, Marco T P Gontijo, Andrea Guarracino, Leanne Haggerty, Edith Heard, Kerstin Howe, Narendra Meena, Fergal J Martin, Eric A Miska, Isabell Rall, Navin B Ramakrishna, Alexandra Sapetschnig, Swati Sinha, Diandian Sun, Francesca F Tricomi, Runjia Qu, Jonathan M D Wood, Tianzhen Wu, Dian J Zhou, Laura G Reinholdt, David J Adams, Clare M Smith, Jingtao Lilue, Thomas M Keane

Faculty Research 2026

We present a collection of 17 high-quality long-read inbred mouse strain genomes with complete annotation (contig N50s of 0.8-33.9 Mbp). This collection includes 12 widely used classical laboratory strains and 5 wild-derived strains. We have resolved previously incomplete genomic regions, including the major histocompatibility complex (MHC), defensin cluster, T cell receptor, and Ly49 complexes. Hundreds of non-reference genes from previous publications not found in GRCm39, such as Defa1, Raet1a, and Klra20 (Ly49T), were localized in the new reference genomes. We conducted a genome-wide scan of variable number tandem repeats (VNTRs) within the coding regions, identifying over 400 genes with VNTR …

2026-02-11 Master Storyteller Johnny Moses Brings Lushootseed Traditions To Lemieux Library, Regina Carrillo

The Spectator Online

No abstract provided.

High-Quality Mouse Reference Genomes Reveal The Structural Complexity Of The Murine Protein-Coding Landscape., Mohab Helmy, Jin U Li, Xinyu F Yan, Rachel K Meade, Elizabeth Anderson, Patrick B Chen, Anne M Czechanski, Tomás Di Domenico, Jonathan Flint, Erik Garrison, Marco T P Gontijo, Andrea Guarracino, Leanne Haggerty, Edith Heard, Kerstin Howe, Narendra Meena, Fergal J Martin, Eric A Miska, Isabell Rall, Navin B Ramakrishna, Alexandra Sapetschnig, Swati Sinha, Diandian Sun, Francesca F Tricomi, Runjia Qu, Jonathan M D Wood, Tianzhen Wu, Dian J Zhou, Laura G Reinholdt, David J Adams, Clare M Smith, Jingtao Lilue, Thomas M Keane

Faculty Research 2026

We present a collection of 17 high-quality long-read inbred mouse strain genomes with complete annotation (contig N50s of 0.8-33.9 Mbp). This collection includes 12 widely used classical laboratory strains and 5 wild-derived strains. We have resolved previously incomplete genomic regions, including the major histocompatibility complex (MHC), defensin cluster, T cell receptor, and Ly49 complexes. Hundreds of non-reference genes from previous publications not found in GRCm39, such as Defa1, Raet1a, and Klra20 (Ly49T), were localized in the new reference genomes. We conducted a genome-wide scan of variable number tandem repeats (VNTRs) within the coding regions, identifying over 400 genes with VNTR …

The College Voice, Vol. 63, No. 6 [February 11, 2026], Connecticut College

2025-2026

No abstract provided.

Targeting The Lung Innate Pathways During Tuberculosis Can Improve Vaccine-Induced Protection Via Th17 Responses In Diversity Outbred Mice, Mushtaq Ahmed, Shibali Das, Bruce A Rosa, Javier Rangel Moreno, Deepak Kaushal, Makedonka Mitreva, Shabaana A Khader

2020-Current year OA Pubs

UNLABELLED: Tuberculosis (TB), caused by the bacterium

IMPORTANCE: Bacille Calmette Guerin (BCG) vaccination in genetically diverse outbred (DO) mice provides significant protection against

Bioactive Lipid-Mediated Structural And Functional Regulation Of The Essential Human Potassium Channel Kir7.1, Qingwei Niu, Simon Vu, Yuanjian Xu, Mingxing Qian, Anastasiia Rudenko, Jin Ye, Jianwei Zeng, Wei Huang, Douglas F Covey, Rui Zhang, Ziao Fu, Polina V Lishko

2020-Current year OA Pubs

The inwardly rectifying potassium channel Kir7.1 is essential for the physiological function of diverse tissues, including the retinal pigment epithelium and the gestational myometrium. Loss-of-function mutations in KCNJ13, which encodes Kir7.1, or conditional ablation of Kir7.1 in the retinal pigment epithelium, lead to early-onset vision loss. Despite strong genetic evidence supporting Kir7.1 as a therapeutic target, its regulation by endogenous ligands-beyond phosphoinositides-remains poorly understood. Here, we report cryo-electron microscopy structures of human Kir7.1 in multiple functional states at resolutions ranging from 2.8 Å to 4.0 Å. These structures uncover the molecular basis of Kir7.1 modulation by PI

Sullivan County 4-H Presents! 2026, Lynn Brewer

UNH Cooperative Extension

No abstract provided.

Exploring Spinal Anatomic Targets For Spinal Cord Stimulation, Jp Ponce, Kevin Hines, Caio Matias

Phase 1

Introduction: For more than 50 years, spinal cord stimulation (SCS) has been effectively employed as a surgical intervention for chronic pain management. Despite its clinical success, up to 40% of patients fail to achieve significant pain relief. Computational models have identified epidural lead positioning and the conus medullaris as potential anatomical targets influencing stimulation efficiency. Given the limited availability of clinical data on potential targets of SCS modulation, this project seeks to investigate these anatomical targets in the clinical setting.

Methods: We conducted a retrospective cohort study involving Epic charts of 105 patients who underwent SCS implantation for chronic pain …

Commonwealth Times 2026-02-11

Commonwealth Times, 1969-

No abstract provided.

Association Between Environmental Exposures To Perfluoroalkyl And Polyfluoroalkyl Substances And Military Veterans Cancer Determination, Stephen A. Pereira Jr

Walden Dissertations and Doctoral Studies

This study involved evaluating whether cumulative exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) was associated with kidney cancer, bladder cancer, and adult leukemia among U.S. veterans. Pooled National Health and Nutrition Examination Survey (NHANES) data from 2005–2015 were analyzed for sample of 2,500 veterans with available serum PFAS measurements and physician-diagnosed cancer histories. This study employed a cross-sectional, correlational design grounded in a post-positivist paradigm. Inclusion required complete data for (a) serum PFAS concentrations, (b) kidney cancer, bladder cancer, and adult leukemia, and (c) covariates age, sex, race/ethnicity, smoking status, and body mass index. Cumulative PFAS was modeled as a …

Agent-Based Model Details For Quantifying Error In Drone-Based Animal Surveys: Animal Density, Distribution And Flight Patterns, Emma A. Schultz, Natasha Ellison-Neary, Landon R. Jones, Kristine O. Evans, Raymond B. Iglay

Research Data

The following dataset pertains to Python scripts of an agent-based model simulating various drone survey design and quantifying potential count bias of stationary animals in fixed landscapes as part of an accepted manuscript in Ecosphere. Simulated animals were distributed among five animal densities (n = 4, 9, 25, 49, 100 animals/survey area) and three distribution patterns (random, uniform, aggregated). Eight drone flight patterns surveyed a 4.16-km² landscape within constraints of real-world battery and line-of-sight limitations. The simplified landscape also provided 100% animal classification (i.e., all animals within image frame observed and identified).

Linking Local Ecological Knowledge And Management Perspectives On Oyster Predation In Mississippi And Alabama, Cynthia Lupton, Eric Sparks, Mark Woodrey, James M. Drymon, Nigel Temple, Steven Scyphers

Research Data

Eastern oysters (Crassostrea virginica) provide critical ecosystem services, yet populations along the northern Gulf Coast are declining due to environmental stressors, such as water quality issues and predation. To evaluate how threats to oysters are perceived across stakeholder groups, we surveyed oyster Farmers and Resource professionals in Mississippi and Alabama about predator impacts, seasonal patterns, and mitigation strategies. Survey responses (n = 21) were analyzed using descriptive statistics, Fisher’s Exact tests, Mann–Whitney U tests, and t-tests. Farmers and Resource professionals identified multiple predators as important sources of mortality, but their relative rankings differed across groups. Resource professionals consistently viewed southern …

2025 State Of Nonprofits And Philanthropy Annual Report, Tessa Tinkler, Cristina Sanchez-Kerr, Laura Deitrick, Eo Hanabusa, Bryan Cardenas, Timothy Nelson, William Piper

State of Nonprofits and Philanthropy in San Diego

The 2025 State of Nonprofits and Philanthropy in San Diego examines how federal policy changes, funding volatility, and rising community needs are reshaping the region’s nonprofit sector. Drawing on survey data from nonprofit leaders and employees, public opinion polling, and financial and employment analysis, the report provides an early assessment of the sector’s financial health, workforce capacity, and its role as a primary access point for services such as housing, food, education, healthcare, and the arts. It highlights mounting pressures on nonprofit infrastructure alongside the sector’s enduring strengths in public trust, collaboration, advocacy, and shared investment strategies that will shape …

Community Participatory Co-Design And Development Of A Digital Diabetes Prevention Education Program For Hispanic Families With Obesity: Mixed Methods Study, Sandra Mihail, Marbelly Partida, Lizette Villanueva, Debbe Thompson, Teresia M O'Connor, Salma M Musaad, Maria J Redondo, Erica G Soltero

Children’s Nutrition Research Center Staff Publications

Background: Digital health interventions (DHIs) can extend the reach of disease prevention interventions; however, few are evidence-based, theoretically grounded, or developed for high-risk youth and families. Co-design approaches engage end users in the design and development of the DHI, which can lead to increased accessibility and engagement.

Objective: This study aimed to describe the adaptation of an evidence-based diabetes prevention program for remote, digital delivery.

Methods: The adaptation of the in-person intervention was guided by a modified Inclusive Digital Health Intervention Design to Promote Health Equity framework and conducted in collaboration with Hispanic adolescents (n=23) with obesity (BMI ≥95th percentile) …

Bioprinting: Revolutionizing Biology With 3d Innovation, Gopalarethinam Janani Ms, Naven Kumar Rk, Agnishwar Girigoswami Prof, Koyeli Girigoswami Prof

Chulalongkorn Medical Journal

3D bioprinting is an innovative technology that enables the creation of bioengineered structures through computer-guided processes. This technique has been in use for more than 35 years and has made a huge contribution in the biomedical field. Utilizing biomaterials with regenerative properties has significantly impacted tissue engineering, regenerative medicine, and pharmaceutical research. Various bioprinting techniques, including inkjet, extrusion, laser-assisted, and stereolithography, offer unique advantages for precise tissue construction. Bioinks used for printing, can be derived from natural and synthetic sources. It ensures biocompatibility, mechanical integrity, and controlled degradation. Advanced bioinks—such as nanoengineered, biomolecular, multimaterial, self-assembling, and stimuli-responsive variants—enhance applications in …

How Does Pattern Of Bone Healing Affect The Strain Of Plate Implant Via Frequency Detection? A Biomechanical Cadaveric Study, Chavarin Amarase, Chanyaphan Virulsri, Pairat Tangpornprasert, Pisitpong Chancharoen, Saran Tantavisut

Chulalongkorn Medical Journal

Background: Detecting bone union is a crucial process in treating bone fractures to prevent complications, including implant failure and bone nonunion. Nowadays, there are many methods and new innovative devices for detecting bone union through strain measurements, such as strain gauges, fluid level displacement, contrast media, and frequency changes. There is also a trend toward increasing these methods in the future. However, the patterns of bone healing studied with these methods still do not provide a standard for determining the true bone healing process. The aim of this study is to identify the most appropriate bone healing pattern for …

Elucidation Of Hub Genes And Pathway Associated With Gut Microbiome Dysbiosis And Alzheimer’S Disease Via Data Analytic Approaches, Premaanand Rawi, Ying Pei Wong, Ee Xion Tan, Anna Pick Kiong Ling

Chulalongkorn Medical Journal

Background: Recent studies have highlighted the relationship between gut microbiome and Alzheimer’s disease (AD), revealing the ways of how gut microbial balance impacts conditions ranging from inflammatory bowel diseases to neurological disorders. The emerging field of the gut-brain-axis suggests production of microbial metabolites influences AD progression. However, there is limited understanding of molecular mechanisms involved in neurological disease when gut microbiome dysbiosis occurs. This study aimed to identify hub genes and pathways associated with gut microbiome dysbiosis and AD through data analytics approaches.

Methods: Public gene expression datasets on gut microbiome dysbiosis, and AD were obtained from the GEO and …

Interview With Cheryl Merrill

Creative Nonfiction Magazine

No abstract provided.

Rock Hounds, David Rompf

Creative Nonfiction Magazine

No abstract provided.

A Preview Of Coming Attractions, David Shields

Creative Nonfiction Magazine

No abstract provided.

Prince Valiant, Robin Hemley

Creative Nonfiction Magazine

No abstract provided.

New Century, Natalie Goldberg

Creative Nonfiction Magazine

No abstract provided.

Marvin Escapes Again

Creative Nonfiction Magazine

No abstract provided.

On Nicknaming

Creative Nonfiction Magazine

No abstract provided.

The Brass Ring

Creative Nonfiction Magazine

No abstract provided.

L’Achat

Creative Nonfiction Magazine

No abstract provided.

Who Holds The Clicker?

Creative Nonfiction Magazine

No abstract provided.

Exploring The Efficacy Of Storytelling In Education About Climate Change, Nina Adjanin, Srijana Katuwal, Heidi Sevestre, Gordon Brooks

Mid-Western Educational Researcher

From bedtime tales to digital narratives, stories wield unparalleled influence, shaping perceptions, and fostering empathy. Through mediums like social media and digital platforms, storytelling becomes a tool for advocacy, amplifying voices, and catalyzing social change. In this qualitative study, 107 higher education students from diverse backgrounds participated. The purpose of this study was to uncover salient beliefs about climate change stories on popular social media platforms among full-time college students. The results are based on three key components of the theory of planned behavior (TPB): affective beliefs, normative beliefs, and control beliefs. The respondents expressed both positive and negative attitudes …

The Effect Of A Preclinical Disability Elective On Medical Student Awareness, Attitudes, And Clinical Competency, Emily Hillmer, Willi Horner-Johnson, Rhonda Eppelsheimer

Developmental Disabilities Network Journal

Opportunities for education on disability are sparse in many medical school curricula, leaving students ill-prepared to address the needs of patients with disabilities in their future careers. The purpose of our study was to design and implement a novel elective course on disability for medical students and evaluate the effect of the course on student awareness, attitudes, and clinical skills. Medical students were surveyed to assess interest in a new disability elective and to understand in what areas they felt their knowledge and skills were most lacking. With support from our University Center for Excellence in Developmental Disability, we utilized …

Book Review: We're All Traditionalists Now (Most Of The Time), Richard H. Fallon, Jr., The Changing Constitution: Constitutional Law In The Trump-Era Supreme Court, Michael Gentithes

ConLawNOW

This review highlights the scope and importance of Richard Fallon’s book, The Changing Constitution: Constitutional Law in the Trump-Era Supreme Court. Fallon, a giant of constitutional work, provides a comprehensive, accessible, and vitally important catalogue of the Court’s methodological changes in his posthumously published book. The book argues that while textualism and originalism “have achieved unparalleled prominence,” the Court is also “not consistently originalist” and often relies on a version of traditionalism, similar to but importantly distinct from originalism, that marks an important and undertheorized change. And in yet other areas, the Court eschews either originalism or traditionalism for …