Digital Commons Network^™

The Poor Rich, Emma Scudero

Fresh Voices: Composition at Cal Poly

No abstract provided.

Increased Neuronal Activity Restores Circadian Function In Drosophila Models Of C9orf72-Als/Ftd, Sho Inami, Benjamin P. Jenny, Oghenerukevwe Akpoghiran, Sara I. Gallagher, Alexandra K. Strich, Ayako Tonoki, Davide Trotti, Aaron R. Haeusler, Kyunghee Koh

Farber Institute for Neuroscience Faculty Papers

Circadian rhythm disruptions are common across neurodegenerative diseases, but their link to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) remains unclear. The C9orf72 hexanucleotide repeat expansion is the most prevalent genetic cause of ALS/FTD. Here, we used Drosophila models expressing pathogenic arginine-rich dipeptides (PR or GR) or GGGGCC hexanucleotide repeats to investigate circadian deficits in C9orf72-ALS/FTD. We found that circadian rhythmicity and period length were altered in a repeat number-, dosage-, expression pattern-, and age-dependent manner. Additionally, we observed lower levels of the neuropeptide PDF, a key regulator of free-running circadian rhythms, as well as decreased projection complexity and …

Human Microglia In Brain Assembloids Display Region-Specific Diversity And Respond To Hyperexcitable Neurons Carrying, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, Yang Yang

Faculty Research 2026

Microglia critically shape neuronal circuit development and function, yet their region-specific properties and roles in distinct circuits of the human brain remain poorly understood. In this study, we generated region-specific brain organoids (cortical, striatal, and midbrain), each integrated with human microglia, to fill this critical gap. Single-cell RNA sequencing uncovered six distinct microglial subtypes exhibiting unique regional signatures, including a subtype highly enriched for the GABA_B receptor gene within striatal organoids. To investigate the contributions of microglia to neural circuitry, we created microglia-incorporated midbrain-striatal assembloids, modeling a core circuit node for many neuropsychiatric disorders, including autism. Using chemogenetics to …

Human Microglia In Brain Assembloids Display Region-Specific Diversity And Respond To Hyperexcitable Neurons Carrying, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, Yang Yang

Faculty Research 2026

Microglia critically shape neuronal circuit development and function, yet their region-specific properties and roles in distinct circuits of the human brain remain poorly understood. In this study, we generated region-specific brain organoids (cortical, striatal, and midbrain), each integrated with human microglia, to fill this critical gap. Single-cell RNA sequencing uncovered six distinct microglial subtypes exhibiting unique regional signatures, including a subtype highly enriched for the GABA_B receptor gene within striatal organoids. To investigate the contributions of microglia to neural circuitry, we created microglia-incorporated midbrain-striatal assembloids, modeling a core circuit node for many neuropsychiatric disorders, including autism. Using chemogenetics to …

Artsksu Presents Professional Series: Kronos Quartet

Bailey School of Music Concert Programs

For 50 years, San Francisco’s Kronos Quartet—David Harrington (violin), Gabriela Díaz (violin), Ayane Kozasa (viola), and Paul Wiancko (cello)—has challenged and reimagined what a string quartet can be. Founded at a time when the form was largely centered on long-established, Western European traditions, Kronos has been at the forefront of revolutionizing the string quartet into a living art form that responds to the people and issues of our time. We are delighted to welcome them to the Bailey Performance Center at KSU!

Volume Cxlv, Number 14, February 20, 2026, Lawrence University

The Lawrentian

No abstract provided.

The Beacon, February 20, 2026, Beacon Staff

The Beacon, 2025-2026

Local musicians put stamp on valentine’s day; Perspectives through the decades: 1960s; Joint flute and vocal student recital; Sony continues run of great animation with “GOAT”; “Wuthering Heights” soundtrack more faithful than film; Godzilla concert theme is more than it seems; Senior practicum: social work majors; Club Spotlight: Swing Dance Line Dance; OC sightseeing: Dutch Heritage Museum; Reaching new heights at NW; Why you should play “Dwarf Fortress; Overwatch dominates in 2026 games; Raiders win again as postseason approaches; Raiders finish strong in final indoor meets; The Winter Olympic’s scandals; Apocalypse now: upcoming chapel series on Revelation

Human Microglia In Brain Assembloids Display Region-Specific Diversity And Respond To Hyperexcitable Neurons Carrying Scn2a Mutation, Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Morgan Robinson, Weihao Li, Yuanrui Zhao, Ye-Eun Yoo, Brody A Deming, Yue Shu, Akila D Abeyaratna, Zhefu Que, Dongshu Du, Matthew Tegtmeyer, Chongli Yuan, William C Skarnes, Zhong-Yin Zhang, Jean-Christophe Rochet, Long-Jun Wu, Yang Yang

The Brown Foundation: Institute of Molecular Medicine

Microglia critically shape neuronal circuit development and function, yet their region-specific properties and roles in distinct circuits of the human brain remain poorly understood. In this study, we generated region-specific brain organoids (cortical, striatal, and midbrain), each integrated with human microglia, to fill this critical gap. Single-cell RNA sequencing uncovered six distinct microglial subtypes exhibiting unique regional signatures, including a subtype highly enriched for the GABAB receptor gene within striatal organoids. To investigate the contributions of microglia to neural circuitry, we created microglia-incorporated midbrain-striatal assembloids, modeling a core circuit node for many neuropsychiatric disorders, including autism. Using chemogenetics to activate …

Mid-Level Perceptual Features, And Not Ambiguity, Accelerate Access To Awareness, Nadav Amir, Uri Maoz, Liad Mudrik

Psychology Faculty Articles and Research

Current theoretical accounts of perception and high-level cognition suggest that awareness plays an active role in disambiguating incoming sensory information. However, the relationship between ambiguity resolution and conscious access remains unclear, partially due to a lack of quantifiable measures of ambiguity. Here, we describe a novel paradigm designed for testing whether more ambiguous stimuli would enjoy preferential access to awareness, as indexed by the time it takes them to break interocular suppression in the breaking continuous flash suppression paradigm. In a series of three experiments, we found that stimuli’s mid-level perceptual features (most likely, visual symmetry levels), rather than their …

2025 And 2026 - Faculty & Staff Research Symposium - Mini, Elizabeth Outka, Lidia Radi

Faculty and Staff Research Symposium Programs

September 26, 2025; November 7, 2025; January 20, 2026; and, February 20, 2026

[Excerpt from the "Welcome"]

"Dear Colleagues,

Welcome to the Faculty and Staff Mini-Symposia Series!

As we gather for the fourth and final installment of this year’s Mini-Symposia Series, we are delighted to continue this new chapter of the Faculty and Staff Research Symposium, building on the extraordinary enthusiasm of the past two years. What began as a single day of conversation and exchange has grown into a cycle of events designed to highlight the intellectual and creative work of our community in even more accessible and collaborative …

Steroid Receptor Coactivators - From Basic Research To Translational Opportunities, Yosef Gilad, Sang Jun Han, David M Lonard

Faculty, Staff and Students Publications

The concept of nuclear receptor (NR) coregulation was proposed nearly two decades before it was experimentally validated. According to this model, NRs - executors of a vast array of transcriptional programs - do not act independently but are governed by a network of regulatory proteins that either activate or repress their biological function. NRs identify the genes to be regulated. However, coregulators ultimately serve as the true controllers of transcriptional outcomes. They recruit cofactors and coordinate the activity of transcriptional complexes, thereby shaping NR-mediated gene expression beyond NRs' intrinsic functionality. The Steroid Receptor Coactivator (SRC) family is the most extensively …

Mind In Nature: John Dewey, Cognitive Science, And A Naturalistic Philosophy For Living, By Mark L. Johnson And Jay Schulkin, Steven Fesmire

Dewey Studies

No abstract provided.

Deweyan Democracy In The Age Of Anthropocene Migration: Building Grassroots Resiliency For An Intercultural Future, Eli Orner Kramer

Dewey Studies

No abstract provided.

A Deweyan Account Of Extrinsic Value And Its Relevance For The Anthropocene, Laurent Riou

Dewey Studies

No abstract provided.

Will Whatever It Takes Be Enough? Dewey, The Crisis Of The Eu, And The Need For An (Inter)Nationalizing Of Education, Stefano Oliverio

Dewey Studies

No abstract provided.

The Hopeful Hashtag: Digital Feminist Publics In The Trump Era, Jennifer Hansen

Dewey Studies

No abstract provided.

Visceral Politics And Heuristic Democracy, Vincent M. Colapietro

Dewey Studies

No abstract provided.

Pragmatism About Nationalism, John J. Stuhr

Dewey Studies

No abstract provided.

Back Matter

Creative Nonfiction Magazine

No abstract provided.

The Sounds Of Your Self, Sonya Huber

Creative Nonfiction Magazine

No abstract provided.

Honest Like A Bear Attack, Clare Magneson

Creative Nonfiction Magazine

No abstract provided.

Do I Die Today?, Francis Doherty

Creative Nonfiction Magazine

No abstract provided.

Misery & Company, A. J. Bermudez

Creative Nonfiction Magazine

No abstract provided.

Monitoring Strategies In Cave Microclimate Studies, Nenad Buzjak, Dalibor Paar, Aurel Persoiu, Christos Pennos, Franci Gabrovšek, Valerija Rossi

International Journal of Speleology

Cave atmospheres are spatially confined but dynamical systems that influence subterranean ecosystems, geomorphological processes, registration and preservation of climatic signals in sedimentary archives, cultural heritage, and conservation management. Despite major advances in cave climatology, methodological approaches to microclimate monitoring remain fragmented and are in some cases still shaped by the long-standing assumption that cave air temperature simply reflects the mean annual surface temperature. This paper revisits that assumption and develops an experience- and literature-based methodological framework for cave microclimate research. Key terminology is addressed by distinguishing between cave climate, cave microclimate, and cave meteorology, and by situating microclimatic variability within …

The Light Eaters, Anna Linn

Natural Resources Journal

No abstract provided.

Protection Forests: Intersections Of Law And Science, Jamison E. Colburn

Natural Resources Journal

The national forests of the eastern United States are where and what they are today based in good part on a mistake. When they were being acquired and established in the early twentieth century, hydrology was in its infancy. Yet many hydrologists and their students in government were promising that these forests would provide significant protection from floods. They promised more than they should have. Forests as protection from floods were embroiled in a contentious and prolonged factual inquiry almost immediately thereafter. Indeed, that inquiry would later mature into a distinct scientific subfield, forest hydrology, that went on to influence …

Rights Of Nature: An Argument For Judicial Economy, Anna Belinski-Huber

Natural Resources Journal

Tracing the evolution of the “rights of nature” movement from Indigenous law and early environmental ethics to modern global applications, this article reframes the debate around codification of legal rights for nature from moral theory to legal efficiency, arguing that the United States implicitly recognizes rights of nature within its environmental jurisprudence and statutory framework. Through detailed analyses of the Endangered Species Act, National Environmental Policy Act, Clean Air Act, and Clean Water Act alongside corresponding case studies, the author demonstrates how courts and Congress have already expanded standing, redefined injury, and recognized nature’s inherent right to exist and flourish. …

What We Leave Behind, Molly Sepkoski St. Clair

Creative Nonfiction Magazine

No abstract provided.

Our World, Ourselves, Clinton Crockett Peters

Creative Nonfiction Magazine

No abstract provided.

Gun Bubbles, Margrét Ann Thors

Creative Nonfiction Magazine

No abstract provided.