Digital Commons Network^™

Trademasks, Matthew Sipe

North Carolina Law Review

No abstract provided.

Individual And Household Factors Associated With Tungiasis In A Marginalized Population In Karamoja, Northeastern Uganda, Lynne Elson, Abneel Matharu, Berrick Otieno, Hermann Feldmeier, Charles Waiswa, Amina Abubakar, Jürgen Krücken, Ulrike Fillinger, Francis Mutebi

Institute for Human Development, East Africa

Background Tungiasis is a neglected tropical skin disease caused by adult female fleas which burrow into the skin of people and animals, causing considerable pain and itching. The distribution of the disease is heterogeneous, with Napak district, Karamoja sub-region of northeastern Uganda having the highest disease burden recorded globally. We aimed to determine the factors associated with this high prevalence to inform future intervention strategies.

Methods We conducted a cross-sectional study to identify factors associated with infection of individual children and adults, and a nested case–control study to identify factors for whole households (families). Infected children were identified through mass-screening …

Caregiver Assessment Of Executive Function Deficits Among Hiv-Infected And Hiv-Exposed Uninfected Preschool Children In Kenya, Antipa Sigilai, Moses Nyongesa, Amin Hassan, Janet Thoya, Rachel Odhiambo, K. Katana, Beatrice Kabunda, Grace Bomu, Charles Newton, Amina Abubakar

Institute for Human Development, East Africa

Background: This study examined caregiver assessment of executive functioning (EF) in perinatally HIV-infected (PHIV) and perinatally HIV-exposed but uninfected (PHEU) Kenyan children, and explored the extent to which various biopsychosocial factors influence EF outcomes.

Methods: Children aged 3–5 years that were PHIV (n = 43), PHEU (n = 52), or HIV-unexposed uninfected (HUU, n = 58) and their caregivers were enrolled in this study. EF was measured using the Childhood Executive Functioning Inventory. Caregivers’ common mental disorders (CMDs) and parenting behaviour were evaluated using the Shona Symptoms Questionnaire (SSQ) and a parenting behaviour scale, respectively. We used analyses …

The Disney Adult: A Consumer That Creates Free Marketing, Emily Elizabeth Kempf

Theses

This research looks at the evolving complex relationship between the Walt Disney Company, The Disney Adult content creators and the fan base. It focuses on how user-generated content (UGC) and social media can play a large role in contemporary marketing strategies. As the target audience has expanded to include Disney Adult, this new audience has become a central part in the company’s marketing strategy encouraging fan engagement across all social media platforms. This research is a qualitative case study on the Disney Adult and how social media content can be used as a core marketing strategy. The Disney Adult influencer …

Artemisia Gentileschi's Judith And Her Maidservant Serves As A Message Of Hope, Holly Kyseth

Theses

This thesis argues that through iconography and specific artistic techniques, Artemisia Gentileschi’s Judith and Her Maidservant utilizes the biblical story of Judith and Holofernes to relay a distinctly female-centered narrative, reflective of the ideals of her seventeenth century Italian community. This piece stands apart from other representations of this narrative in that Judith was commonly shown as either dainty yet violent in the act of decapitating Holofernes, or as a saintly victor proudly displaying his head to her people. With Judith and Her Maidservant, Artemisia displays an obvious sororal alliance between Judith and her servant Abra, while cleverly implementing Caravaggesque …

Mediators Of The Dead: Funerary Strategies And Material Practice In The Final Jōmon Period, Celeste Marie Tran

Theses

Shakōki-dogū are prehistoric clay figurines from Japan’s Final Jōmon period, characterized by enlarged, goggle-eyed features. In both scholarship writing and museum display texts, generalized thematic labels or iconographic readings sometimes reduce the corpus’s internal variability. This study examines a focused set of Final Jōmon shakōki-dogū from northern Honshū (Tōhoku) and Hokkaidō (Figures 2–6) through their formal and material evidence—shape, surface treatment, and condition—read alongside published excavation reports and catalogue records. It asks what these figurines can be shown to do, as prehistoric artworks, within death-related practice when interpretation is anchored to observable features and documented context, rather than to a …

Immersive Experience Design In Contemporary Theme Parks: A Case Study Of Universal Epic Universe, Roi Andre F. Ramos

Experience Industry Management

The evolution of contemporary theme parks has increasingly centered on large-scale immersive environments designed to transport guests into cohesive narrative worlds. The purpose of this study was to examine the immersive design practices utilized at Universal Epic Universe. A case study was conducted to evaluate five themed lands, four attractions, and four queue environments using a researcher-developed observational instrument. The results of this study determined that Epic Universe effectively sustains immersion through architectural enclosure, intellectual property-based world-building, sensory layering, and interactive technologies that increase guest agency. The park demonstrates a cohesive “self-contained land” model that minimizes negative cues and extends …

Reimagining The Laguna Lake Driving Range, Audrey Bonifacio, Jessica Rice

City and Regional Planning

The Laguna Lake Municipal Golf Course is located in San Luis Obispo, California, and is operated by the city. Recently, the community, city staff, and the City Council have begun a conversation regarding the use of the golf course. To explore the different uses, this senior project presents four alternative developments for a selected area of the golf course. These four uses include enhancing the existing driving range, a sports facility, a children’s center, and a senior living community. To assess these alternatives, the project explores current urban planning theories, development trends, and case studies for each use. Through this …

Against The Drafter: An Empirical And Theoretical Analysis Of The Doctrine Of Contra Proferentem, Farshad Ghodoosi, Tal Kastner

Fordham Law Review

Contra proferentem, the enduring maxim that directs courts to interpret an ambiguity in a contract against its drafter, appears simple on its face. Although it might be best known as a fundamental principle of insurance law, contra proferentem figures in courts’ interpretation of a range of contract types. As an interpretive rule of thumb that parties can easily override with a simple contract provision, the doctrine and its boilerplate antidote seem to offer a straightforward means to facilitate private ordering—a central goal of contract law.

However, neither courts’ application of the doctrine in case law nor contract drafters’ treatment …

Postcolonial Ecocriticism And The Recovery Of Hope: Okri, Dangarembga, And The Spiritual, John C. Hawley

English

This essay stages a comparative ecocritical reading of African and transnational texts—Cajetan Iheka’s Naturalizing Africa, Ben Okri’s Every Leaf a Hallelujah, Tsitsi Dangarembga’s This Mournable Body, Greg Sarris’s Becoming Story, and Karen Armstrong’s Sacred Nature—to examine how narrative re-situates the human within more-than-human worlds. Drawing on Iheka’s “aesthetics of proximity,” postcolonial theory, and critical posthumanism, it contrasts Okri’s hopeful, child-centered fable of multispecies reciprocity with Dangarembga’s portrayal of “slow violence,” psychic dispossession, and eco-touristic commodification in neoliberal Zimbabwe. Indigenous and spiritual frameworks in Sarris and Armstrong further disclose ancient precedents for posthuman ethics, foregrounding humility, …

March 2026, Office Of Research

Research Update

No abstract provided.

Launch Skills: Virtual Career Camp Connects Rural Youth To Diverse Career Pathways, Caroline Homan, Meagan Hoffman

Journal of Youth Development

Rural youth often encounter persistent barriers in career and workforce readiness, including limited access to career exploration resources, mentorship, and post-secondary exposure, challenges that are compounded by geographic isolation and higher rates of rural poverty. To address these gaps, this manuscript describes the development and implementation of Launch Skills, a virtual career camp designed to broaden rural youths’ awareness of career pathways within food, agriculture, natural resources management, and human sciences (FANH). Grounded in Positive Youth Development principles, Launch Skills was collaboratively developed by North Dakota State University Extension and South Dakota State University Extension to provide flexible, accessible, and …

From Doctrine To Practice: Shūrā-Centred Islamic Ethics For Sustainable Ecological Solutions, Fatima Dhanani, Cecilee Glaus Jones

Abdou Filali-Ansary Occasional Paper Series

This paper examines how Islamic ethics, when translated into lived practice, generate both moral frameworks and scalable solutions to pressing ecological challenges. Focusing on shūrā, tawḥīd, khilāfa, and taʿaddudiyya, and drawing on case studies of Stewardship Canada and the Aga Khan University’s Carbon Management Tool, the authors show how Islamic values move beyond doctrinal abstraction to guide institutional decision-making, programme design, and community engagement. More than treating ethics as fixed theological propositions, they frame them as negotiated, context-sensitive processes that align with ecological resilience, distributive justice, and economic viability.

Grounded in shūrā …

Lies That Matter: Retheorizing Rape And The Limits Of Consent, Seran Gee

Nevada Law Journal

This Article proposes a novel assent-based framework for understanding rape law, challenging the traditional focus on consent as the sole determinant of rape. It argues that rape occurs when there is an absence of assent, rather than simply a lack of consent. The Article distinguishes between assent, which reflects a feeling of willingness, and consent, which is an exercise of autonomy that waives one’s right to bodily integrity. By incorporating this distinction, the assent model provides a more nuanced approach to rape law, explaining why certain deceptions—such as misrepresenting the nature of a sexual act—constitute rape, while others do not. …

Key Predictors Of Postpartum Depression And Anxiety Symptoms Among Mothers In Kilifi, Kenya: A Machine Learning Approach, Faith Benson, Rachel Odhiambo, Willie Brink, Anthony Ngugi, Akbar Waljee, Eileen Weinheimer-Haus, Cheryl Moyer, Ji Zhu, Amina Abubakar

Institute for Human Development, East Africa

Background:

The burden of maternal postpartum depression and anxiety is disproportionately high in sub-Saharan Africa (SSA), yet the use of advanced analytical methods to capture the complex interplay of variables influencing these conditions remains underexplored.

Objective:

To apply machine learning (ML) methods to predict depressive and anxiety symptoms in postpartum mothers and to identify key and actionable predictors.

Methods:

This cross-sectional study included 1,995 biological mothers of singleton infants aged 0–6 months, using survey data collected between March 2023 and March 2024 in Kaloleni and Rabai sub-counties, Kilifi County, Kenya, within the Kaloleni–Rabai Health and Demographic Surveillance …

Aging Reduces Motivation Through Decreased Bdnf Expression In The Ventral Tegmental Area, Hanyue Cecilia Lei, Kyle E Parker, Chao-Cheng Kuo, Carla M Yuede, Jordan G Mccall, Shin-Ichiro Imai

2020-Current year OA Pubs

Age-associated reduced motivation is a hallmark of neuropsychiatric disorders in the elderly. In our rapidly aging societies, it is critical to keep motivation levels high enough to promote healthspan and lifespan. However, how motivation is reduced during aging remains unknown. Here, we used multiple mouse models to evaluate motivation and related affective states in young and old mice. We also compared the effect of social isolation, a common stressor in aged populations, to those of aging. We found that both social isolation and aging decreased motivation in mice, but that Bdnf expression in the ventral tegmental area (VTA) was selectively …

Bach2 Regulates T Cell Lineage State To Enhance Car T Cell Function, Tien-Ching Chang, Amanda Heard, John Lattin, John M Warrington, Amanda Barrett, Jack H Landmann, Yangdon Tenzin, Vishaal Ganesh, Bryant Thompson, Sadia Afrin, Deepesh Kumar Gupta, Ju-Fang Chang, Julie Ritchey, Mehmet Emrah Selli, Yu-Sung Hsu, A J Federico, Avery Horn, Michael P Meers, John F Dipersio, Nathan Singh, Et Al.

2020-Current year OA Pubs

Nearly all chimeric antigen receptors (CARs) signal in the absence of antigen, referred to as 'tonic signaling'. Tonic signaling of CARs containing 41BB domains enhances T cell fitness and function, in contrast to the exhaustion driven by CD28-containing CARs. Here we show that 41BB induces BACH2, a transcriptional regulator that directs stem and memory programs. Overexpression of BACH2 successfully prevented exhaustion but locked CAR T cells in a quiescent state. We linked BACH2 to a degradation domain to tune BACH2, enabling us to prevent exhaustion while enabling potent effector function that broadly enhanced the long-term efficacy of CAR T cells …

Cdk4/6 Inhibition Mitigates Chemotherapy-Induced Expansion Of Tp53-Mutant Clonal Hematopoiesis, Irenaeus C C Chan, Giulia Petrone, J Scott Beeler, Duc Tran, Griffen Mustion, Catrina Fronick, Carlos Cruchaga, Kelly L Bolton, Et Al.

2020-Current year OA Pubs

Therapy-related myeloid neoplasm (tMN) is a fatal consequence of exposure to cytotoxic therapy administered in the treatment of cancer. Individuals with pre-existing TP53 clonal hematopoiesis (CH) are at high risk of tMN, with avoidance of therapy being the only strategy to reduce tMN risk. Here, in four randomized clinical trials, we show that the CDK4/6 inhibitor trilaciclib, given in conjunction with a variety of chemotherapeutic regimens and across diverse populations of patients with cancer, mitigates chemotherapy-related expansion of CH clones with mutations in DNA damage response genes, including TP53. This finding was also observed in a syngeneic mouse model of …

Signal Peptidase Complex Mediates Rotavirus Vp7 Processing And Virion Assembly, Xuejiao Zhu, Enkai Li, Liliana Sanchez-Tacuba, Wandy Beatty, Bin Li, Siyuan Ding

2020-Current year OA Pubs

For viruses that replicate in the proximity of or bud at the endoplasmic reticulum (ER) associated membranes, proper processing of their glycoproteins is critical for successful infection. Rotavirus outer capsid protein VP7 is an ER-resident protein. However, its N-terminal signal peptide is removed by an unknown proteolytic mechanism. In this study, we leveraged tandem affinity purification followed by high-resolution mass spectrometry to profile host proteins that interact with VP7. We identified members of the signal peptidase complex (SPC) family as important host factors that facilitate rotavirus infection. CRISPR knockout or siRNA knockdown of distinct SPC subunits resulted in significant decrease …

Learning Gendered Speech: How Media Exposure Shapes American Learners’ Perceptions Of Japanese Pronouns, Emma Bell, David Raymond

Research Papers and Posters from ASCL 60.20: Languages and Scripts of Gender, Class, and Nation

Language choices play an integral part in an individual’s identity, especially in how they are perceived by others. Further, the context under which an individual learns a language has a major influence on their language choices. This influence is particularly significant in Japanese: a language that is often described as having clearly defined “masculine” and “feminine” speech styles. The following research is a study on how beginner Japanese language learners’ pedagogical and environmental backgrounds affect their perception of gendered pronouns. An online survey was conducted to compare perceptions of the appropriateness of various pronouns across gendered contexts between beginner learners …

Native Chinese Speakers’ Perspective On Foreign Speakers Of Their Language, Veronika Šímová, Jack Inglis

Research Papers and Posters from ASCL 60.20: Languages and Scripts of Gender, Class, and Nation

As previous research suggests, native speakers of Chinese may hold unfair perceptions of non-native learners of their language. This might lead to a belief among Chinese native speakers that non-Asians cannot speak Chinese fluently or at a native level. This is a potentially harmful assumption that has implications affecting new learners, experienced learners, and future learners. Existing research on the topic has shown that ethnically Chinese L2 speakers of Mandarin are often perceived more positively than non-Asian L2 speakers. Other scholars have shown the perceived relationships between looking Chinese and speaking Chinese, as well as assumptions that Asians should speak …

Same Film, Different Story: Cross-Cultural Adaptation Of Movie Titles In Thai And Cantonese Markets, Krittin Hirunchupong, Yi Gao

Research Papers and Posters from ASCL 60.20: Languages and Scripts of Gender, Class, and Nation

Movie title translations play a significant role in cross-cultural marketing and interpersonal communication among audiences. Due to cultural differences and naming conventions, English titles are often adapted creatively in Asian contexts for informative, aesthetic and commercial purposes. Diverse translation strategies share organic relations with Glocalization trends, indicating the degree of cultural openness in international discourse. This study combines media analysis that investigates translation strategy trends in top rated films in Thailand and Hong Kong with survey data on bilingual audiences’ interaction with title backtranslations. Both quantitative and qualitative data reflect that Thai and Cantonese film titles shape audience expectations and …

Sacbe 1 And Classic Maya Urban Culture, Traci Ardren, Scott R. Hutson, Travis W. Stanton, Patrick Rohrer, Justin P. Lowry

Anthropology Faculty Publications

One of the most significant engineering accomplishments of Maya civilization is Sacbe 1, a raised road connecting the ancient urban centers of Yaxuna and Coba. Using new lidar data in concert with excavation, epigraphic inscriptions, and landscape reconnaissance, we show that settlement and an urban experience emanated westward from Coba along the sacbe. The leaders of Coba - in particular, an ambitious seventh-century queen - used the sacbe to expand the political and cultural influence of their dynasty into the center of the peninsula while securing territory and resources. Gaps in the sacbe, precise delineation of its many curves, and …

Devaluation Insensitivity Of Event Related Potentials Associated With Food Cues, Thomas D. Sambrook, Andy J. Wills, Ben Hardwick, Jeremy Goslin

School of Psychology

Eating in the absence of hunger represents a failure of homeostatic mechanisms responsible for energy balance and is a cause of obesity. The pervasive presence of food cues in the modern environment may play a role in this phenomenon. The present study used the technique of satiety-specific selective devaluation to investigate eating in the absence of hunger in the context of a reinforcement learning task. While participants’ performance on the task suggested that food on which they had sated no longer held value for them, event related potentials following images of the food were unaffected by the devaluation. Food cues …

Discriminatory Effect(S), W. Kerrel Murray

Faculty Scholarship

In constitutional law, “discriminatory effect” often matters. So it’s surprising how often we don’t quite know what it means. That opacity is trans-substantive; it has been a recent pitfall in contexts as diverse as admissions-policy challenges under the Equal Protection Clause, personal-jurisdiction disputes under the “dormant” Commerce Clause, and, under the Free Exercise Clause, requests for exemptions from facially neutral laws.

This Article’s first corrective is a novel typology. Constitutional discriminatory effect is murky, in part, because it has many types; we perceive it in myriad ways across constitutional domains. Comprehending this complexity enhances our understanding of what discriminatory-effect rules …

Synovial Fibroblast Responses To Different Types Of Injury Resulting In Cartilage Repair Or Osteoarthritis, Fraser L Collins, Alexander J Knights, Tristan Maerz, Anke J Roelofs, Cosimo De Bari

2020-Current year OA Pubs

OBJECTIVE: Single-cell RNA-sequencing (scRNA-seq) has advanced our understanding of the heterogeneity of synovial fibroblasts and their roles in tissue repair and osteoarthritis. Here, we compared the fibroblast responses to different types and duration of joint injury in mice.

DESIGN: Published scRNA-seq data of synovial fibroblasts from a model of joint surface injury (JSI, day 6) and two post-traumatic osteoarthritis models, destabilisation of the medial meniscus (DMM, day 7 and 2 months) and anterior cruciate ligament rupture (ACLR, day 7 and day 28), were integrated and analysed using clustering, DEG, gene-set enrichment, regulon, pseudotime trajectory and cell-cycle analyses.

RESULTS: The response …

Assessing Liver And Iron Markers In Steady State Pediatric Scd Patients To Ascertain The Hepatic Consequences Of Hemotransfusion: A Case-Control Study In Ghana, John Agyemang Sah, Stephen Twumasi, Allwell Adofo Ayirebi, Benedict Sackey, Enoch Odame Anto, Richard Vikpebah Duneeh, Ebenezer Senu, Veronica Barnor, David Boakye, Daniel Nii Martey Antonio, Wina Ivy Ofori Boadu

Research outputs 2022 to 2026

Background and Aims: Between 200,000 and 300,000 children with sickle cell disease (SCD) are born in Africa every year, with 75%–80% of these children living in sub-Saharan Africa. In newborns with SCD, significant iron accumulations may develop because of their increased risk of requiring multiple blood transfusions. This study aimed to assess the hepatic effects of hemotransfusion in pediatric SCD patients in steady state by measuring liver and iron markers. Methods: This case-control research enrolled 120 children with SCD and 60 children without SCD from the Asokwa Children's Hospital Sickle Cell Clinic and Child Welfare Clinic. Participants’ sociodemographic information, history …

Trends In Health-Based Drinking Water Violations For Coliform Bacteria In The United States, Amber Lyon-Colbert, Kshipra Sharma

Public Health Faculty Publications

This research seeks to determine whether health-based drinking water violations for total coliforms have increased since the Revised Total Coliform Bacteria Rule established in 2013 and fully implemented in 2016 by the Environmental Protection Agency under the Safe Drinking Water Act; as well as determine the geographic regions, states and territories in the United States with the highest number of health-based Total Coliform Rule and Revised Total Coliform Rule violations. We obtained data for drinking water violations involving total coliform bacteria from the Safe Drinking Water Information System for 2000-2019 and trend analysis was completed by state, region, water source, …

Knights Of Guinevere, Knights Of Terrace, Abigail Hyacinthe Woelk

Gateway Reader- Individual Papers

• The Problem: The researcher addresses a gap in media criticism regarding Dana Terrace's animated series Knights of Guinevere, arguing that critics like Rosa Perez over-emphasize the show's jabs at Disney while neglecting its broader allegorical critiques of corporate pollution and capitalist labor practices.

• The Method: The study analyzes the pilot episode of Knights of Guinevere by evaluating its framing, character design, and setting alongside a comparative critique of Rosa Perez's 2025 article "This Animated Sci-Fi Series Fires a Shot at Disney".

• Quantitative Finding: The core text references specific timestamps from the 2025 pilot episode, including the introduction of narrative …

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Ferroptosis As A Pathological Driver In Niemann-Pick Disease Type C, Kayla Linda Sanchez

Loma Linda University Electronic Theses, Dissertations & Projects

Niemann–Pick Disease Type C (NPC) is a hereditary neurodegenerative disease characterized by selective cell vulnerability, particularly affecting cerebellar anterior Purkinje neurons. These neurons exhibit a distinctive pattern of degeneration due to the loss of NPC1 and/or NPC2 protein function, progressively extending towards posterior cerebellar regions. Historically, research has described NPC as a disorder of intracellular cholesterol handling; however, cholesterol-lowering therapies have not effectively prevented neurological deterioration, and the mechanisms underlying selective neuronal vulnerability remain unclear. Ferroptosis, previously referred to as oxytosis, is a regulated form of cell death driver by iron-induced lipid peroxidation. It has been implicated in several neurodegenerative …