Digital Commons Network^™

Magnify Is A Universal Molecular Anchoring Strategy For Expansion Microscopy, Aleksandra Klimas, Brendan R Gallagher, Piyumi Wijesekara, Sinda Fekir, Emma F Dibernardo, Zhangyu Cheng, Donna B Stolz, Franca Cambi, Simon C Watkins, Steven L Brody, Amjad Horani, Alison L Barth, Christopher I Moore, Xi Ren, Yongxin Zhao

2020-Current year OA Pubs

Expansion microscopy enables nanoimaging with conventional microscopes by physically and isotropically magnifying preserved biological specimens embedded in a crosslinked water-swellable hydrogel. Current expansion microscopy protocols require prior treatment with reactive anchoring chemicals to link specific labels and biomolecule classes to the gel. We describe a strategy called Magnify, which uses a mechanically sturdy gel that retains nucleic acids, proteins and lipids without the need for a separate anchoring step. Magnify expands biological specimens up to 11 times and facilitates imaging of cells and tissues with effectively around 25-nm resolution using a diffraction-limited objective lens of about 280 nm on conventional …

Office Of Grants And Research Services Annual Report 2022 - 2023, Office Of Grants And Research Services, Seton Hall University

Office of Grants and Research Annual Reports

No abstract provided.

Problem-Based Learning Of Heuristic Methods For Decision Problems In Mathematics, Computer Science And Industrial Engineering, Felix Engelhardt, Christina Büsing, Sabrina Schmitz

Practice Papers

In a digitalized world, most processes can be formalised, measured and described mathematically. The use of analytical methods to optimise such models and decisions constitutes operational research (OR), developing new methods for a specific problem and analysing them are part of discrete optimisation (DO). However, there is limited research on OR and application driven DO in higher education. Furthermore, neither is well integrated into engineering education research.

In this work, we present a case study of an interdisciplinary Master’s course on heuristic methods in the context of OR and DO. We discuss to what extent wellestablished approaches from engineering education …

Improving The Perception, Assessment And Diagnosis Of Females With Autism, Sydney Anne Steen

All Electronic Theses and Dissertations

This literature review examines current biases in perception, assessment, and diagnosis of Autism Spectrum Disorder (ASD) for females. Males lead in the number of diagnoses of ASD, however, many of the assessments used to evaluate for ASD are based on male autistic tendencies rather than female. This lack of inclusion is causing many females to be missed in early detection of ASD diagnoses. This literature review looks at female characteristics of ASD to be considered during evaluation for ASD and what future implications need to be considered in the education systems to best reach females with ASD.

A Reverse Exponential-Generalized Truncated Logarithmic (Rev-Egtl) Distribution For Ordered Spacing Statistics, Mohieddine Rahmouni, Ayman Orabi

Journal of Statistics Applications & Probability

This paper extends the exponential-generalized truncated logarithmic (EGTL) distribution to model reverse ordered statistics. Our procedure generalizes the exponential-logarithmic (EL) distribution to a distribution more appropriate for modelling the mth-largest value of lifetime instead of the maximum lifetime. We give a general form of the new family of spacing distribution appropriate for descending ordered statistics. General forms of the pdf and the failure rate function as well as their properties are presented for some special cases. The parameters’ estimation is attained by the maximum likelihood (ML) and the expectation maximization (EM) algorithms. The application study is illustrated based on four …

Ratio Of Coefficients Of Variation For Comparing The Dispersions Of Several Independent Populations, Abbas Bahrampour, Zeynab Avazzadeh, Mohamad Reza Mahmoudi

Journal of Statistics Applications & Probability

The coefficient of variation (CV) is an important and useful statistical tool for comparing several populations. In cases where there are multiple populations with different means and variances, the ratio of the coefficients of variation (CVs) is a good way to compare the dispersion of the populations. Because of the possible minor differences between multiple CVs and the lack of a robust interpretation, the ratio of CVs is more accurate than the difference of CVs. When a statistical analysis consists of some simultaneous statistical tests such as equality of several CVs, multiple testing is useful. As an example, the multiple …

Native American Exposure To Iodine-131 From Nuclear Weapons Testing In Nevada, Clark University, Abel Russ, Patricia George, Robert Goble, Stefano Crema, Chunling Liu, Dedee Sanchez

Clark University

A great deal of work has been done reconstructing doses from Nevada Test Site fallout, yet the unique exposures of Native American communities continue to be neglected. It is possible to estimate the exposures of these communities through a process of collaborative information gathering and analysis. This paper builds on a previous exercise that demonstrated the substantial doses received through the consumption of contaminated game. The updated model includes new information on the deposition of iodine-131, an assessment of the neonatal thyroid doses received through breast milk, an exploration of the effect of population mobility on dose estimates, and estimates …

Characterization Of P75ntr Interactions And Associated Effects On Neurodegeneration Associated With Parkinson's Disease, Bradley R. Kraemer

Summer Community of Scholars (RCEU and HCR) Project Proposals

No abstract provided.

Analysis Of Gene Expression Investigating Biology Underlying High Regenerative Ability Of Marine Invertebrate Botrylloides Violaceus, Cassidy Andrasz

Baker/Koob Endowments Awarded Projects

The marine invertebrate Botrylloides violaceus is a species of tunicate found in Morro Bay, CA with the extraordinary ability to regenerate its whole body. Furthermore, tunicates are the closest known relatives to vertebrates. Due to this organism's regenerative ability and relationship to vertebrates, it is of great interest to investigate the underlying mechanisms of regeneration and review its potential applications to related vertebrate organisms, including humans. The genome of B. violaceus was sequenced and assembled at Cal Poly, SLO which allowed for the proposed experiments to analyze gene expression, a field called transcriptomics. Transcriptomics tells us how the organism is …

Effects Of Disulfiram On The Metabolome Of Mrsa, Surya Teja Naidu

Theses, Dissertations and Capstones

Disulfiram, known as Antabuse®, is an oral drug for the treatment of alcohol dependence. Previous studies have indicated that disulfiram (DSF) exhibits antibacterial effects, particularly against Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Our study delves into the antibacterial mechanism of DSF in MRSA through High-Pressure Liquid Chromatography (HPLC) metabolomics, investigating the underlying mechanism of DSF effects on thiamine and amino acid metabolism. Thiamine pyrophosphate (TPP) plays a crucial role as a cofactor for critical enzymes such as transketolase, pyruvate dehydrogenase, and 2-oxoglutarate dehydrogenase. These enzymes are integral to the carbohydrate metabolism process within bacterial cells. TPP also contributes …

2023 Sdsu Data Science Symposium Schedule, South Dakota State University

SDSU Data Science Symposium Programs

No abstract provided.

Utility Of Shear Wave Elastography In Breast Cancer Diagnosis: A Systematic Review And Meta-Analysis, Aishwarya Pillai

Yale Medicine Thesis Digital Library

In the United States, breast cancer is one of the most diagnosed cancers in women. Early detection, often via mammography, and intervention have been shown to reduce mortality. However, not all cancers are mammographically evident in early stages, if at all. As a result, ultrasound has been increasingly used to supplement mammography for breast cancer detection and assessment, particularly in dense breasts. Recent advancements in ultrasonography include the ability to characterize the stiffness of biological tissues. Shear Wave Elastography (SWE) is one such development used to quantify tissue stiffness within a region of interest.

The resistance of soft tissue to …

Annual Report Of The Officers Of The Town Of Jackson, New Hampshire For The Fiscal Year Ending December 31, 2022., Jackson Town Representatives

Jackson, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

The Episodes, Jampa Dorje

High Mountain Valley Local Authors Collection Online Content

No abstract provided.

Fay B. Kaigler Children's Book Festival 2023 Program, Usm School Of Library And Information Science

Fay B. Kaigler Children's Book Festival Programs

No abstract provided.

Assessing Ecotoxicity Of Surface Water And Sediment In The Little Scioto River, Leah Suzanne Morgan

Theses, Dissertations and Capstones

Aquatic toxicology evaluates the impact of pollution on freshwater and marine biota. Polycyclic aromatic hydrocarbons (PAHs) are one class of chemicals prevalent in the environment that impair aquatic organisms. This study examined the effect of contaminated surface water and sediments from a former wood treatment facility on four aquatic species: Pimephales promelas (fathead minnow), Ceriodaphnia dubia (water flea), Chironomus dilutus (midge), and Daphnia magna (water flea). The findings showed that sediment contamination had no significant effect on survival and growth of C. dilutus or on survival of D. magna. Surface water contamination began to have a significant effect on …

Autism Resources In Rural America, Amanda Long

Integrated Studies

The topic of this final project centers around the lack of services that are available to autistic children and adults in rural America and the steps that should be taken the ensure services are available as the growing population of children grow older and need full-time care. Our modern society as well as the current healthcare system are not prepared for the growing need of an ageing disabled population. Will these disabled children and young adults flood the current long-term care facilities that are already established? Will the already stretched thin Medicare and Medicaid system cover the costs associated with …

Introduction: The Life And Legacies Of Kenneth Kaunda In Southern Africa, Mary Mbewe, Marja Hinfelaar, Duncan Money

Zambia Social Science Journal

Zambia’s first President, Kenneth Kaunda (known widely as KK), passed away on 17 June 2021 at the age of 97. This marked the end of an era for many, and not only in Zambia. Kaunda belonged to the last of a generation of African leaders who fought for independence from colonial rule and had his own brand of political and economic philosophies (Cheeseman and Sishuwa, 2021). Given the momentous occasion of the passing of one of Africa’s biggest icons, as editors we felt it was timely to organise a conference dedicated to Kaunda and his legacy, which took place in …

Arming Zambia In The “Dark Forest Of International Politics”: Kenneth Kaunda, Britain, And Arms Diplomacy, 1963-1971, Jeff Schauer

Zambia Social Science Journal

From the breakup of the Central African Federation in 1963 until the departure of British officers and trainers in the early 1970s, Kenneth Kaunda led the Zambian government in negotiating arms purchases from British arms manufacturers, with the assistance of the British government. These transactions were intimately connected to security guarantees against Rhodesian aggression that Kaunda negotiated with the former colonial power, and British attempts to foster Zambian foreign policy and technological dependency. While this decade of negotiations had its origins in the contentious local distribution of military resources at the end of Federation, by the time it ended, it …

Nonconsumptive Effects Of Crustaceans And An Echinoderm On Spat Of The Eastern Oyster Crassostrea Virginica (Gmelin, 1791), Maria Rosa, Mike Gilman, Sarah Anderson, Adrian Beckford, Ben Gilfond, Nicole Wright, David M. Hudson

Biology Faculty Publications

Predation by crustaceans and echinoderms is a significant driver of mortality for sessile invertebrates in near-shore marine ecosystems. As a response, shellfish growers use predator exclusion cages to grow their product. Oysters grown in these cages and clams in and under nets have been observed to exhibit thinner, brittle shells, which is not optimal for market, nor for those being grown for restoration purposes. Here, the nonconsumptive predator effects of several native and nonnative predators on shell morphology of Crassostrea virginica oyster spat. Juvenile (1–3 mm) seed oysters were exposed separately to chemical cues of five different predators and one …

Effects Of Color On Sustained Attention And Recall, Harry Steinharter

Psychology Honors Papers

Sustained attention, the process by which people focus on something for a long period of time, is a well documented phenomenon. It has enormous implications for life, from tasks as complex as surgery to as mundane as driving a car. However the effect that color has on sustained attention is rarely studied. The current study examined the effect of the presence of canonical color in images versus inverted colors, or black and white images. This effect was measured via a go/no-go paradigm gradual onset continuous performance task (gradCPT). A memory task was presented after the gradCPT in order to determine …

Examining The Role Of Chronic Stress In Cancer Progression And Metastasis: P53 As A Potential Mechanism, Jillian R. Dean

Behavioral Neuroscience Honors Papers

The influence of stress on the development and progression of cancer has been a longstanding hypothesis. Chronic stress can have a significant impact on the immune system and inflammatory response, potentially leading to decline of the body's immune capabilities (Segerstrom & Miller, 2004). Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which triggers the release of stress hormones, such as cortisol (Smith & Vale, 2006). When chronically activated, this can lead to corresponding changes in the immune system, including decreased activity of natural killer cells, which play a crucial role in identifying and destroying cancer cells. Chronic inflammation has also been shown …

Cognitive And Neural Development In A Rodent Model Of Ptsd From Maternal Maltreatment, Nhi Doan

Behavioral Neuroscience Honors Papers

Childhood neglect influences development and increases the risk for and severity of mental illness. Previous study has shown that early life stress (ELS) alters stress circuitry, elevates basal stress hormone, and impairs regulation of the HPA. In this study, we seek to understand the impacts of decreased quality of care and trauma on the cognitive and neural development of rats at adolescence. We used a 1-week limited bedding protocol to induce fragmented care in dams and a 10-minute exposure to fox odor to induce stress in offspring later. Memory function and patterns of brain activity following stressor exposure were assessed …

The Effects Of Trailside/Non-Trailside Sample Collection And Tree Communities On Biodiversity Of Mushroom-Forming Fungi In Public Green Spaces Of New London, Connecticut, Quincy Dowling

Botany Honors Papers

The Kingdom Fungi holds a wealth of biodiversity and potential for better supporting both natural and human communities (Lange, 2014). Mushroom-forming fungi have potential value as sustainable and accessible sources of food in public green spaces (Rombach & Dean, 2023). The purpose of this investigation was to examine the effect of trailside disturbance and tree communities on the diversity and community composition of mushroom-forming fungi in New London, Connecticut. Six public green spaces were identified and surveyed for species richness of mushroom-forming fungi. At each site, two foraging areas of equal area were defined: one along either side of a …

Actividad 2: Proyecto Pb&J, Patrick Young

Tema 1: Estructura y proceso

Los proyectos complejos, como la construcción de un puente, requieren una planificación minuciosa. La gestión de proyectos es la disciplina que consiste en planificar y controlar el trabajo de un equipo para alcanzar un objetivo específico. El éxito de la gestión de proyectos requiere una cuidadosa consideración de los plazos, los presupuestos y los recursos disponibles.

El diagrama de Gantt es una herramienta de gestión de proyectos que muestra las tareas en términos de su tiempo de ejecución, interdependencia y recursos disponibles. Desarrollado por el ingeniero estadounidense Henry Gantt, este diagrama se empleó por primera vez en la construcción naval, …

Actividad 1: ¡Construye Fuerte!, Patrick Young

Tema 1: Estructura y proceso

El hormigón es el material de construcción más común para estructuras grandes. El hormigón se compone de tres materiales:

• Áridos: Arena y grava.
• Cemento: Un pegamento químico que mantiene los agregados unidos con gran fuerza.
• Agua: El agua no solo ayuda a mezclar y verter el hormigón, sino que se une al cemento en una reacción química y se incorpora al hormigón terminado.

Las cubiertas de los puentes deben soportar el peso de todos los automóviles y camiones que transitan por ellos. Las diferentes partes de las cubiertas de los puentes experimentan distintos tipos de fuerzas. La compresión es una …

Actividad 1: Lo De Adela, Patrick Young

Tema 2: Por la ciudad

Si pregunta a algunos de los residentes más antiguos de su barrio cómo era la ciudad hace 30 o 40 años, le dirán que había muchos espacios o campos vacíos Si les pregunta si están contentos con las numerosas viviendas, comercios, carreteras e industrias que existen ahora, es posible que digan que han perdido parte de su comunidad, pero que, al mismo tiempo, han ganado en infraestructuras, carreteras, industrias, puestos de trabajo, valor de la propiedad y expansión de la comunidad.

Implantar más carreteras en una ciudad no es una decisión fácil. Para que el proyecto se lleve a cabo, …

Actividad 2: Ruta Óptima, Patrick Young

Tema 2: Por la ciudad

Los sistemas de navegación de los vehículos utilizan información de la ubicación para ayudar a los conductores a decidir qué ruta tomar. Muchos de los sistemas de navegación alertan a los conductores de peligros en la carretera. Los cierres de carreteras, los accidentes, el clima y otros peligros afectan tanto los tiempos de viaje como las rutas elegidas. La colaboración y el intercambio de información entre la autopista o carretera, los servicios públicos y los sistemas de navegación son necesarios para informar a los conductores.

Graduate Catalog, 2023-2024, Valparaiso University

Graduate Catalogs

No abstract provided.

Exploring The Transition From General Ultrasound To Veterinary Ultrasound: Challenges And Opportunities, Kali Foltz, Juliette Myers

Student Research Poster Presentations 2023

Objective: The objective of the interview and research study was to identify the various challenges and opportunities that may be presented to an individual seeking a transition from human to veterinary ultrasound.

Methods: An interview was conducted between two senior sonography students and one experienced veterinary sonographer.

Results: The interview and research provided information and detail on the transition process, what a sonographer should know prior to the transition, and what benefits and obstacles a sonographer may encounter.