Digital Commons Network^™

Chronic And Postprandial Metabolic Responses To A Ketogenic Diet Compared To High-Carbohydrate And Habitual Diets In Trained Competitive Cyclists And Triathletes: A Randomized Crossover Trial, Austin J. Graybeal, Andreas Kreutzer, Kamiah Moss, Petra Rack, Garrett Augsburger, Robyn Braun-Trocchio, Jada L. Willis, Meena Shah

Faculty Publications

Extreme carbohydrate deficits during a ketogenic diet (KD) may result in metabolic adaptations reflective of low energy availability; however, the manifestation of these adaptations outside of exercise have yet to be elucidated in cyclists and triathletes. The purpose of this study is to investigate the chronic and postprandial metabolic responses to a KD compared to a high-carbohydrate diet (HCD) and habitual diet (HD) in trained competitive cyclists and triathletes. For this randomized crossover trial, six trained competitive cyclist and triathletes (F: 4, M: 2) followed an ad libitum KD and HCD for 14 d each after their HD. Fasting energy …

Discovery And Characterization Of A New Class Of O-Linking Oligosaccharyltransferases From The Moraxellaceae Family, Cory J Knoot, Paeton L Wantuch, Lloyd S Robinson, David A Rosen, Nichollas E Scott, Christian M Harding

2020-Current year OA Pubs

Bacterial protein glycosylation is commonly mediated by oligosaccharyltransferases (OTases) that transfer oligosaccharides en bloc from preassembled lipid-linked precursors to acceptor proteins. Natively, O-linking OTases usually transfer a single repeat unit of the O-antigen or capsular polysaccharide to the side chains of serine or threonine on acceptor proteins. Three major families of bacterial O-linking OTases have been described: PglL, PglS, and TfpO. TfpO is limited to transferring short oligosaccharides both in its native context and when heterologously expressed in glycoengineered Escherichia coli. On the other hand, PglL and PglS can transfer long-chain polysaccharides when expressed in glycoengineered E. coli. Herein, we …

The 2022 Monkeypox Epidemic And What Has Led To The Current State Of The Disease In The Us: A Systematic Review, Samriddh Chaudhari, Leah Treffeisen, Jaswinder Virk, Taral Parikh, Naveen Prasad Gopalakrishnan Ravikumar, Ashish M. Goti, Lokesh Goyal, Kanica Yashi

Student Publications

Monkeypox virus (MPOX) is a zoonotic disease in humans. It is similar genetically to its virus family member, smallpox. This virus has been studied since the 1970s. The virus remains endemic to the Congo and West African regions, but non-endemic spreads have been cited. The most recent non-endemic outbreak in the spring of 2022 amidst the current COVID-19 pandemic is of interest due to its impact on global medical, economic, and societal climates. This literature review aims to highlight the virology, clinical signs and symptoms, diagnosis, prevention, and treatment of MPOX and discuss the social implications of the recent 2022 …

Concentrations And Estimation Of The Annual Effective Doses Of Natural Radioactivity Uptake Through Ingestion Of Virgin And Extra Virgin Olive Oil, Eman Ahmed Albdady, Mahmoud El Ghazaly, Saad Abd El Aaal, Mostafa Abdelrahman, Nasef Mansour, Mona Elsayed Frarrag

International Journal of Thin Film Science and Technology

This study assesses the natural radioactive concentrations in virgin olive oil in Egypt. The presence and concentrations of naturally occurring radioactive materials (NORM) in 26 olive oil samples collected from different locations in Saini were conducted using two techniques: gamma spectroscopy using a high purity germanium detector (HPGe) and inductively coupled plasma-mass spectroscopy (ICP-MS). Because of their very low concentrations, the radioactivity of NORM was below the detection limits of the HPGe detector for the time of measurement, On the other hand ICP-MS results showed the concentrations of natural radioactive elements such as uranium and thorium in some examined samples. …

Markets, Businesses, And Consumption In Refugees Settlements: A Review And Future Research Trajectory, Stefanie Beninger

Markets, Globalization & Development Review

The global refugee crisis is increasing, and many refugees will end up living in refugee settlements, also known as refugee camps. These settlements have dynamic economic activities, and such activities deserve attention. This paper draws upon academic and practitioner work to describe pertinent aspects of consumption, businesses, and markets in these settlements, including in relation to multiple stakeholders. These stakeholders can include, for example, governments, aid agencies, private sector, and local community groups. Based on these insights, the paper identifies key theoretical areas in need of attention related to these economic activities in refugee settlements, including market change, resilience, and …

Full Issue: Fall 2017

DePaul Magazine

In this issue of DePaul Magazine meet alumni employed by the Chicago Cubs and the White Sox, alumni firemen who share what it’s like to battle a blaze, learn about DePaul’s study abroad program, and discover the compelling World War I story of a DePaul legacy family.

Rethinking Food Regime As Gender Regime: Agrarian Change And The Politics Of Social Reproduction, Diana Mincyte

Publications and Research

This paper presents a synthetic reading of the food regime and gender regime concepts to consider current trends in deagrarianization. Its underlying goal is to articulate a research agenda for studying the food regime through the lens of gender and labor relations. Combining insights from feminist scholarship and early debates on family farming in agrarian studies, it underscores the role of social reproduction in shaping agro-food systems. Focusing on relations in production it reconsiders family, kinship and strong ties as a form of social organization in capitalist production, emphasizes the significance of ideology on the household level, and underscores the …

Echinococcus Multilocularis Calreticulin Interferes With C1q-Mediated Complement Activation, Siqi Xian, Lujuan Chen, Yan Yan, Jianfang Chen, Guixia Yu, Yuxiao Shao, Bin Zhan, Yanhai Wang, Limei Zhao

Faculty, Staff and Students Publications

As a zoonotic disease caused by Echinococcus multilocularis larvae, alveolar echinococcosis (AE) is one of the most severe forms of parasitic infection. Over a long evolutional process E. multilocularis has developed complex strategies to escape host immune attack and survive within a host. However, the mechanisms underlying immune evasion remain unclear. Here we investigated the binding activity of E. multilocularis calreticulin (EmCRT), a highly conserved Ca2+-binding protein, to human complement C1q and its ability to inhibit classical complement activation. ELISA, Far Western blotting and immunoprecipitation results demonstrated that both recombinant and natural EmCRTs bound to human C1q, …

The Larsen Lab: A Center For Nanotherapeutic Strategies In The Central Nervous System (Cns2), Jessica M. Larsen

Journal of the South Carolina Academy of Science

No abstract provided.

Book Review: Animal, Vegetable, Junk: A History Of Food, From Sustainable To Suicidal, Miguel A. Quintana

Natural Resources Journal

No abstract provided.

Mst1-Mediated Phosphorylation Of Nur77 Improves The Endometrial Receptivity In Human And Mice, Xinyu Cai, Yue Jiang, Zhiwen Cao, Mei Zhang, Na Kong, Lina Yu, Yedong Tang, Shuangbo Kong, Wenbo Deng, Haibin Wang, Jianxin Sun, Lijun Ding, Ruiwei Jiang, Haixiang Sun, Guijun Yan

Center for Translational Medicine Faculty Papers

Background: Successful embryo implantation requires the attachment of a blastocyst to the receptive endometrial epithelium, which was disturbed in the women with recurrent implantation failure (RIF). Endometrial β3-integrin was the most important adhesion molecule contributing to endometrial receptivity in both humans and mice. Nur77 has been proven indispensable for fertility in mice, here we explore the role of Nur77 on embryo-epithelial adhesion and potential treatment to embryo implantation failure.

Methods: The expression and location of Mst1 and Nur77 in endometrium from fertile women and RIF patients were examined by IHC, qRT-PCR and Western blotting. In vitro kinase assay following with …

Graph Theoretical Measures Of Fast Ripple Networks Improve The Accuracy Of Post-Operative Seizure Outcome Prediction, Shennan A Weiss, Itzhak Fried, Chengyuan Wu, Ashwini Sharan, Daniel Y. Rubinstein, Jerome Engel, Michael R Sperling, Richard J Staba

Department of Neurosurgery Faculty Papers

Fast ripples (FR) are a biomarker of epileptogenic brain, but when larger portions of FR generating regions are resected seizure freedom is not always achieved. To evaluate and improve the diagnostic accuracy of FR resection for predicting seizure freedom we compared the FR resection ratio (RR) with FR network graph theoretical measures. In 23 patients FR were semi-automatically detected and quantified in stereo EEG recordings during sleep. MRI normalization and co-registration localized contacts and relation to resection margins. The number of FR, and graph theoretical measures, which were spatial (i.e., FR rate-distance radius) or temporal correlational (i.e., FR mutual information), …

Relationship Of Abdominal Circumference And Trunk Length With Spinal Anesthesia Block Height In Geriatric Patients Undergoing Transurethral Resection Of Prostate, Muhammad Yahya, Aliya Ahmed, Iayla Fatima, Muhammad Nasir

Department of Anaesthesia

Introduction: Spinal anesthesia is commonly used for various surgical procedures. Prediction of spinal anesthesia block height is always a challenging task for anesthetists. Higher than desired levels of spinal anesthesia blocks are associated with serious side effects, while inadequate block height does not provide satisfactory surgical anesthesia. In this study, we observed the relationship between the ratio of trunk length (TL) and square of the abdominal circumference (AC²) and spinal anesthesia sensory block height in geriatric patients undergoing transurethral resection of the prostate (TURP).
Material & Methods: This is a cross-sectional study conducted at the Aga Khan University …

Silencing Mir-146a-5p Protects Against Injury-Induced Osteoarthritis In Mice, Haocheng Qin, Cuicui Wang, Yonghua He, Aiwu Lu, Tiandao Li, Bo Zhang, Jie Shen

2020-Current year OA Pubs

Osteoarthritis (OA), the most prevalent joint disease and the leading cause of disability, remains an incurable disease largely because the etiology and pathogenesis underlying this degenerative process are poorly understood. Low-grade inflammation within joints is a well-established factor that disturbs joint homeostasis and leads to an imbalance between anabolic and catabolic processes in articular cartilage; however, the complexity of the network between inflammatory factors that often involves positive and negative feedback loops makes current anti-cytokine therapy ineffective. MicroRNAs (miRNAs) have emerged as key regulators to control inflammation, and aberrant miRNAs expression has recently been linked to OA pathophysiology. In the …

Commercialization Of Separated Human Body Parts - Unpacking Instrumentalization Approach, Arseny Shevelev, Georgy Shevelev

Pace International Law Review

The principle of non-commercialization, which prohibits trade in separated human body parts, has long been firmly embedded in many European legal orders and has become an integral part of them. However, many new uses for human biomaterials have now been discovered, and the need for them has reached a historical climax. This paper aims to explain the main tenets of non-commercialization theory, including such principles as human dignity and need to protect human’s health, and to show that these categories have so far been understood in a very one-sided and visceral way, and largely in contradiction to their true spirit. …

From Well-Side Meetings To Pelican Strategy: A Context-Based Approach To Combat Corruption, Lili Yan

Pace International Law Review

This article takes up the question of what strategy is to be used among different communities to eradicate corruption across borders. The debate between two legal scholars, Steven Salbu and Philip Nichols, over the viability of extraterritorial application of anti-bribery laws remains thought-provoking when we look at the effectiveness of the OECD Anti-bribery Convention or FCPA in curbing corruption. Empirical research shows that firms from countries with extraterritorial legal restrictions do not necessarily refrain themselves from paying bribes in foreign transactions. This article ties the Salbu-Nichols’ debate, ISCT, mediating institutions theory, and Pelican Gambits strategy together to structure a context …

The Future Of Pandemics: Land Use Controls As Means Of Preventing Zoonotic Disease, Bailey Andree

Pace International Law Review

Zoonotic diseases are increasing in frequency as climate change worsens around the world, with the recent COVID-19 pandemic highlighting the inadequate mechanisms in place to counteract disease spread. This article reviews various zoonotic diseases and their patterns of spread, highlighting land use change as the key driver of disease to demonstrate the need for legal intervention. International land use law is a little-developed subsect of environmental law that holds the key to combating this disease spread, and this article proposes solutions through this legal lens. Land use techniques which may be used to combat disease spread include conservation laws, setback …

Lychas Jakli Sp. N. (Scorpiones: Buthidae) From Indonesia, František Kovařík

Euscorpius

A new species Lychas jakli sp. n. (Scorpiones: Buthidae) is described from Indonesia, fully illustrated with color photos showing its morphology and habitus. A new synonymy is proposed: Lychas kotao Lourenço, 2020 = Lychas mucronatus (Fabricius, 1798), syn. n.

Survival Rates Of Band‐Tailed Pigeons Estimated Using Passive Integrated Transponder Tags, Daniel P. Collins, Guthrie S. Zimmerman, Scott A. Carleton, William L. Kendall, Christopher L. Coxen

United States Fish and Wildlife Service: Publications

Obtaining survival estimates on the Interior population of band-tailed pigeons (Patagioenas fasciata) is challenging because they are trap shy, but the joint use of passive integrated transponder (PIT) tags and bands is a potential solution. We investigated the use of PIT tags to passively recapture band‐tailed pigeon at 3 locations in New Mexico, USA, to estimate survival. From 2013–2015, we captured, banded, and marked >600 individual band‐tailed pigeons with PIT tags. To estimate annual survival rates, we used a Barker multi‐state joint live and dead encounters and resighting model. Survival models excluding transience had survival estimates across site, …

Full Issue: Winter 2019

DePaul Magazine

This issue of DePaul Magazine offers a pictorial look at the new Holtschneider Performance Center, home of DePaul's School of Music. Take the tour at "Unveiled."

Mouse Phenome Database: Towards A More Fair-Compliant And Trust-Worthy Data Repository And Tool Suite For Phenotypes And Genotypes., Molly A. Bogue, Robyn L Ball, Vivek M. Philip, David O Walton, Matthew H Dunn, Georgi Kolishovski, Anna Lamoureux, Matthew Gerring, Hongping Liang, Jake Emerson, Timothy M Stearns, Hao He, Gaurab Mukherjee, John Bluis, Sejal Desai, Beth A. Sundberg, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, Elissa J Chesler

Faculty Research 2023

The Mouse Phenome Database (MPD; https://phenome.jax.org; RRID:SCR_003212), supported by the US National Institutes of Health, is a Biomedical Data Repository listed in the Trans-NIH Biomedical Informatics Coordinating Committee registry. As an increasingly FAIR-compliant and TRUST-worthy data repository, MPD accepts phenotype and genotype data from mouse experiments and curates, organizes, integrates, archives, and distributes those data using community standards. Data are accompanied by rich metadata, including widely used ontologies and detailed protocols. Data are from all over the world and represent genetic, behavioral, morphological, and physiological disease-related characteristics in mice at baseline or those exposed to drugs or other treatments. MPD …

Full Issue: Fall 2019

DePaul Magazine

This issue of DePaul Magazine announces the establishment of The Grace School of Applied Diplomacy in the College of Liberal Arts and Social Sciences. Learn more about transprofessional diplomacy and this exciting new endeavor in the cover story "Expanding the Borders of Diplomacy."

Hemispheric Reconstructions: Post-Emancipation Social Movements And Capitalist Reaction In Colombia And The United States, James E. Sanders

History Faculty Publications

As historians have begun to conceptualize the U.S. Civil War as a global event, so too must they consider Reconstruction as a political process that transcended national boundaries. The United States and Colombia both abolished slavery during civil wars; ex-slaves in both societies struggled for full citizenship and landholding, partially succeeding for a time; in both societies, a harsh reaction ripped full citizenship from the freedpeople and denied their claims to the land. These events, usually studied only as part of a national story in either the United States or Colombia, can also be understood, and perhaps be better understood, …

Thirteen New Species Of Butterflies (Lepidoptera: Hesperiidae) From Texas, Jing Zhang, Qian Cong, Nick V. Grishin

Insecta Mundi

Analyses of whole genomic shotgun datasets, COI barcodes, morphology, and historical literature suggest that the following 13 butterfly species from the family Hesperiidae (Lepidoptera: Papilionoidea) in Texas, USA are distinct from their closest named relatives and therefore are described as new (type localities are given in parenthesis): Spicauda atelis Grishin, new species (Hidalgo Co., Mission), Urbanus (Urbanus) rickardi Grishin, new species (Hidalgo Co., nr. Madero), Urbanus (Urbanus) oplerorum Grishin, new spe­cies (Hidalgo Co., Mission/Madero), Telegonus tsongae Grishin, new species (Starr Co., Roma), Autochton caballo Grishin, new species (Hidalgo Co., 6 mi W of Hidalgo), Epargyreus fractigutta …

Desire In The Iliad: The Force That Moves The Epic And Its Audience, Rachel H. Lesser

Gettysburg College Faculty Books

This book is the first study to examine desire in the Iliad in a comprehensive way and to explain its relationship to the epic’s narrative structure and audience reception. It offers a new reading of the poem that shows how the characters’ desires, especially those of the mortal hero Achilleus and the divine king Zeus, motivate plot and keep the audience engaged with the epic until and even beyond its end. The author argues that the characters’ desires are primarily organized in narrative triangles that feature two parties in conflict over a third. A variety of desires animate these triangles, …

Temperature Fluctuation Alters Optimal Predator Community Composition For Anticipated Biological Control, Amanda N. Laubmeier, Nusrat Tabassum, Brigitte Tenhumberg

School of Biological Sciences: Faculty Publications

Alongside pesticides and specialist predators, natural communities of generalist beetle and spider predators play an important role in suppressing agricultural pests. However, the predation pressure of natural communities can be unpredictable. Overall predation pressure is influenced by a dense network of potential intraguild interactions, which are further shaped by species traits and environmental factors. Understanding how these different influences combine to impact pest control is especially important in the context of changing global temperatures. Recent empirical studies have demonstrated that the foraging behavior of arthropod predators is influenced by an interaction between temperature and predator body size. To explore the …

Full Issue: Fall 2018

DePaul Magazine

DePaul's new president, A. Gabriel Esteban, PhD, and his wife, Jo, talk about their lives and their first year at DePaul in this issue of DePaul Magazine. Discover their favorite places in Chicago in "The Road to DePaul."

Mouse Pancreatic Peptide Hormones Probed At The Sub-Single-Islet Level: The Effects Of Acute Corticosterone Treatment, Aleksandra Antevska, Connor C. Long, Samuel D. Dupuy, J. Jason Collier, Michael D. Karlstad, Thanh D. Do

Division of Basic Science Faculty Publications

We combine liquid chromatography coupled with ion mobility spectrometry-mass spectrometry to elucidate how short exposure to corticosterone (Cort) alters the output of mouse pancreatic islet hormones. The workflow enables the robust separation of mouse insulin 1 (Ins1) and insulin 2 (Ins2) and the detection of major islet hormones in a homogenate equivalent to 100-150 islet cells. We show that Ins2 has a unique structure and is degraded much faster than Ins1. Further investigation indicates that Ins2 may populate both T and R states, whereas Ins1 may not. The assemblies of Ins1’s B-chain also introduce more structural heterogeneity than Ins2. Collectively, …

The Evolution Of Life History Traits And Their Thermal Plasticity In Daphnia, Larry L. Bowman Jr., David M. Post

ETSU Faculty Works

Few studies have explored the relative strength of ecogeographic versus lineage-specific effects on a global scale, particularly for poikilotherms, those organisms whose internal temperature varies with their environment. Here, we compile a global dataset of life history traits in Daphnia, at the species-and population-level, and use those data to parse the relative influences of lineage-specific effects and climate. We also compare the thermal response (plasticity) of life history traits and their dependence on climate, temperature, precipitation, and latitude. We found that the mode of evolution for life history traits varies but that the thermal response of life history traits most …

Design And Synthesis Of Substituted N,3,3-Triphenylpropanamide And 1-Benzhydryl-N-Phenylazetidine-3-Carboxamide Analogs And Their Biological Evaluation, Michael Dorogan

Theses and Dissertations

As D₁R agonism has significant implications in the treatment of cognitive deficits, we sought to develop novel D₁R PAMs, through the derigidification of BMS D₁R PAM hit compound. While we were able to synthesize derigidified analogs of the BMS hit compound, derigidification did not produce active D₁R ligands.