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Mimosa 2022/2023, Jacksonville State University

JSU Yearbooks

The JSU Yearbook Collection spans the years from 1926 to the present. The publication began in 1926 as the Teacola (some volumes spelled "Teacoala") and continued under this title through 1933. The yearbook appears to have ceased printing after that year; the student newspaper took the name Teacola (later changed to the Collegian and finally the Chanticleer) and began publication in 1934. The yearbook started up again in 1947 under the name Mimosa. The Library holds all volume years that were printed: 1926-1933, 1947-1950, 1952-present.

Poly(Pro-Curcumin) Materials Exhibit Dual Release Rates And Prolonged Antioxidant Activity As Thin Films And Self-Assembled Particles, Ruiwen Chen, Jessica L. Funnell, Geraldine B. Quinones, Marvin Bentley, Jeffrey R. Capadona, Ryan J. Gilbert, Edmund F. Palermo

Chemical and Biochemical Engineering Faculty Research & Creative Works

Curcumin is a natural polyphenol that exhibits remarkable antioxidant and anti-inflammatory activities; however, its clinical application is limited in part by its physiological instability. Here, we report the synthesis of curcumin-derived polyesters that release curcumin upon hydrolytic degradation to improve curcumin stability and solubility in physiological conditions. Curcumin was incorporated in the polymer backbone by a one-pot condensation polymerization in the presence of sebacoyl chloride and polyethylene glycol (PEG, Mn = 1 kDa). The thermal and mechanical properties, surface wettability, self-assembly behavior, and drug-release kinetics all depend sensitively on the mole percentage of curcumin incorporated in these statistical copolymers. Curcumin …

Full Issue: Summer 2014

DePaul Magazine

Learn about DePaul's highly ranked video game design program, how a DePaul initiative teaches Latinx high schoolers about media literacy through hands-on journalism, and DePaul professors leading a grassroots effort to support green infrastructure development on Chicago's South Side.

Technology Meets Tils: Deciphering T Cell Function In The -Omics Era, William H Hudson, Andreas Wieland

Faculty, Staff and Students Publications

T cells are at the centerstage of cancer immunology due to their ability to recognize mutations within tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate exhausted T cell responses have transformed the clinical management of several malignancies. In parallel, the development of novel multidimensional analysis platforms such as single-cell RNA-sequencing and high-dimensional flow cytometry has yielded unprecedented insights into immune cell biology. This convergence has revealed substantial heterogeneity of tumor-infiltrating immune cells, both within single tumors, across tumor types, and among cancer patients. Here, we discuss the opportunities and challenges of studying the complex tumor microenvironment with …

Technology Meets Tils: Deciphering T Cell Function In The -Omics Era, William H Hudson, Andreas Wieland

Faculty, Staff and Students Publications

T cells are at the centerstage of cancer immunology due to their ability to recognize mutations within tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate exhausted T cell responses have transformed the clinical management of several malignancies. In parallel, the development of novel multidimensional analysis platforms such as single-cell RNA-sequencing and high-dimensional flow cytometry has yielded unprecedented insights into immune cell biology. This convergence has revealed substantial heterogeneity of tumor-infiltrating immune cells, both within single tumors, across tumor types, and among cancer patients. Here, we discuss the opportunities and challenges of studying the complex tumor microenvironment with …

Isolation And Identification Of Bacterial Causes Of Diarrhea In Children Less Than 2 Years Old In Al-Muthanna Governorate, Karima Al Salihi, Mohammed Hassan Younise

Muthanna Medical Journal

Diarrhea is the second leading cause of children’s death under five years of age worldwide. The most common microbiological causes of gastroenteritis vary by age group, geographic region, and type of diarrhea. This study designed to identify the bacterial causes of children’s diarrhea under two years of age in Samawah /Al-Muthanna Governorate. Out of 84 patients, 21 sterile stool swabs were collected from children suffering from diarrhea in the Maternity and Children Hospital in Samawah for the period from 1 to 31 December 2021. Samples were cultured on selective diagnostic culture media. Antibiotic sensitivity test was performed for bacterial isolates …

Ethno-Conservation Of New Guinea Singing Dog Among Tribes In Pegunungan Tengah, Papua, Indonesia, Arni Syawal, Satyawan Pudyatmoko, Lies Rahayu Wijayanti Faida, Elieser Viktor Sirami, Esti Gesang Setyadi, Pratita Puradyatmika, Rendy Enggar Suwandi, Muhammad Ali Imron

Forest and Society

Interactions between humans and carnivores have been range from positive to negative, occasionally leading to human-wildlife conflict in many parts of the world. While dogs have roles to support humans, wild dogs such as wolf, dingoes, and singing dogs have both potential positive and negative roles for humans. We gathered knowledge among tribes in Pegunungan Tengah of Papua, Indonesia on their interactions with the New Guinea Singing Dog (NGSD) using an ethno-conservation approach. We conducted in-depth interviews using both emit and etic approaches with informants from the Amungme, Damal, Moni and Dani (Lani) tribes, who live in the habitat of …

Impact And Mitigation Measures Of Covid-19 Towards Food Security Through Participation In Forest Management By Community In Sook, Keningau District, Sabah, Vilaretti Atin, Walter Lintangah

Forest and Society

The COVID-19 pandemic has significantly impacted food security for the people due to the imposition of stringent measures to halt the spread of COVID-19 transmission. This study aimed to measure the community's perception of the level of COVID-19 impacts on their food security and to identify the community's participation in forest management around the Forest Management Unit (FMU) in Sook, Keningau District of Sabah, to improve their livelihood. A mixed-method approach was conducted where a total of 122 respondents were sampled using a questionnaire survey, focus group discussion with communities, and expert interviews to gather more valuable data. The result …

Docosahexaenoic Acid Stability In Ready-To-Use Therapeutic Food, Genevieve James, Kevin Stephenson, Meghan Callaghan-Gillespie, Mohamed Tabita Kamara, Hui Gyu Park, J Thomas Brenna, Mark J Manary

2020-Current year OA Pubs

Ready-to-use therapeutic food (RUTF) is used to treat young children diagnosed with severe acute malnutrition. RUTF with low and balanced linoleic and alpha-linolenic acid, plus omega-3 docosahexaenoic acid (DHA), supports long-term cognitive recovery. DHA is prone to degradation due to peroxidation, possibly exacerbated by the iron inherently in RUTF. Our goals were to prepare benchtop and manufacturing scale of RUTF formulations that include DHA and measure its retention. Twenty-seven RUTF formulas with base ingredients, including oats, high oleic or commodity peanuts, and encapsulated or oil-based DHA at various levels were prepared at benchtop scale, followed by seven months of climate-controlled …

A Cdh3-Β-Catenin-Laminin Signaling Axis In A Subset Of Breast Tumor Leader Cells Control Leader Cell Polarization And Directional Collective Migration, Priscilla Y Hwang, Jairaj Mathur, Yanyang Cao, Jose Almeida, Jiayu Ye, Vasilios Morikis, Daphne Cornish, Maria Clarke, Sheila A Stewart, Amit Pathak, Gregory D Longmore

2020-Current year OA Pubs

Carcinoma dissemination can occur when heterogeneous tumor and tumor-stromal cell clusters migrate together via collective migration. Cells at the front lead and direct collective migration, yet how these leader cells form and direct migration are not fully appreciated. From live videos of primary mouse and human breast tumor organoids in a 3D microfluidic system mimicking native breast tumor microenvironment, we developed 3D computational models, which hypothesize that leader cells need to generate high protrusive forces and overcome extracellular matrix (ECM) resistance at the leading edge. From single-cell sequencing analyses, we find that leader cells are heterogeneous and identify and isolate …

A Molecular Switch Between Mammalian Mll Complexes Dictates Response To Menin-Mll Inhibition, Yadira M Soto-Feliciano, Francisco J Sánchez-Rivera, Florian Perner, Douglas W Barrows, Edward R Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X Shirley Liu, Andrei V Krivtsov, Maximiliano Meneses, Elisa De Stanchina, Richard M Stone, Scott A Armstrong, Scott W Lowe, C David Allis

Faculty, Staff and Student Publications

Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and biochemical approaches, we discovered a conserved molecular switch between the MLL1-Menin and MLL3/4-UTX chromatin-modifying complexes that dictates response to Menin-MLL inhibitors. MLL1-Menin safeguards leukemia survival by impeding the binding of the MLL3/4-UTX complex at a subset of target gene promoters. Disrupting the Menin-MLL1 interaction triggers UTX-dependent transcriptional activation of a tumor-suppressive program that dictates therapeutic responses in murine and human leukemia. Therapeutic reactivation of this program using CDK4/6 inhibitors …

Identification Of Collaborative Cross Mouse Strains Permissive To Salmonella Enterica Serovar Typhi Infection, Kishore Alugupalli, Sudeep Kothari, Matthew P Cravens, Justin A Walker, Darren T Dougharty, Gregory S. Dickinson, Louis A Gatto, Andreas J Bäumler, Tamding Wangdi, Darla R Miller, Fernando Pardo-Manuel De Villena, Linda D Siracusa

Department of Microbiology and Immunology Faculty Papers

Salmonella enterica serovar Typhi is the causative agent of typhoid fever restricted to humans and does not replicate in commonly used inbred mice. Genetic variation in humans is far greater and more complex than that in a single inbred strain of mice. The Collaborative Cross (CC) is a large panel of recombinant inbred strains which has a wider range of genetic diversity than laboratory inbred mouse strains. We found that the CC003/Unc and CC053/Unc strains are permissive to intraperitoneal but not oral route of S. Typhi infection and show histopathological changes characteristic of human typhoid. These CC strains are immunocompetent, …

Using Innovative Copper‑Loaded Activated Alumina (Cu/Aa) As The Catalyst For Catalytic Wet Peroxidation (Cwpo) Of Catechol, Vijayalakshmi Gosu, Archana Dhakar, Tian C. Zhang, Rao Y. Surampalli, Verraboina Ubbaramaiah

Department of Civil and Environmental Engineering: Faculty Publications

In this study, copper-loaded activated alumina (Cu/AA) was synthesized and used for the CWPO of catechol (a representative refractory organic pollutant). Various characterization techniques were deployed to characterize the catalysts, e.g., activated alumina (AA), as well as pristine and spent 1% Cu/AA. The innovative 1% Cu/AA catalyst exhibited good thermal stability up to 1173 K with a marginal weight loss of 13%. The Cu species were well dispersed on the activated alumina framework with no significant cluster formation. Typically, the average copper particle size of 5 nm was dispersed on the AA framework. Catechol removal was observed to be 92% …

New Types Of Topologies And Neutrosophic Topologies, Florentin Smarandache

Neutrosophic Systems with Applications

In this paper, we recall the six new types of topologies that we introduced in the last years (2019-2022), such as: Refined Neutrosophic Topology, Refined Neutrosophic Crisp Topology, NeutroTopology, AntiTopology, SuperHyperTopology, and Neutrosophic SuperHyperTopology.

Editorial: What Does Not Kill You Makes You Stronger: Interactions Between Environmental Stresses And Microbial Virulence, Liang Wang, Ling-Jun Zhan, Michael J. Wise

Research outputs 2022 to 2026

The intriguing sit-and-wait hypothesis predicts that “virulence should be positively correlated with durability in the external environment because high durability reduces the dependence of transmission on host mobility” (Walther and Ewald, 2004) (Figure 1). Since the hypothesis was first proposed in the late 20th century (Ewald, 1983), both theoretical and computational studies have been reporting the relationships between environmental durability and microbial virulence (Sundberg et al., 2014; Wang et al., 2017, 2018, 2019a,b, 2020; Rafaluk-Mohr, 2019; Li et al., 2021) [...].

Book Review: In The Shadow Of The Palms: More-Than-Human Becomings In West Papua. Sophie Chao. Duke University Press, 2022, Carter Beale

Forest and Society

In the Shadow of the Palms offers a haunting and novel perspective on themes of dispossession and alienation wrought by the expansion of oil palm agribusiness in Indonesia. Drawing on fieldwork with a Marind community in the Upper Bian in West Papua, the text endeavors to describe such dispossessory dynamics from an embodied Marind ontology. Meticulous descriptions of interactions with various animal and plant species evidence a profound intersubjectivity of human and environment in the Marind world. Moreover, these encounters with multi-species entanglements often reveal how the Marind accommodate and assimilate the spiritual and material incursions inflicted by expanding oil …

Will Indigenous Ecological Knowledge Vanish? Assessing Persistence Of The Celako Kemali In Farming Practices Among The Serawainese In Bengkulu, Indonesia, Panji Suminar

Forest and Society

Indonesia is home to many indigenous peoples who can preserve the environment through their traditions amid the increasing of external values ​​and lifestyles’ penetration. The following presents the indigenous ecological knowledge of the Serawai people in the form of the celako kemali. Based on insights from the Indigenous research methods, this study aims first to assess the persistence of the celako kemali as a method for farming practices. Second, to identify transmission patterns of the celako kemali among generations in the Serawai community. This study found that there were 19 types of celako kemali. The current analysis demonstrates …

Living Through Crises Due To Successive Commodity Booms And Busts: Investigating The Changing Peasants' Farming Style In Rural Indonesia, Muchlas Dharmawan Tualle, A. Mujetahid, Muhammad Dassir, Nurhady Sirimorok, A. Khalid Muhammad, Andi Vika Faradiba Muin, Aryo Dwi Prasetyo

Forest and Society

This study aims to explain how a peasant community makes decisions in response to recurring crises in order to maintain their farms, and the extent to which vulnerability contexts and (external) institutions influence peasants’ decision-making regarding their livelihoods. In doing so, we present a case study of the Village of Ranga, in the South Sulawesi Province, Indonesia, where data collected through semi-structured interviews, observation, and Focus Group Discussion (FGD). Data regarding farmers' livelihood strategies in responding to the crises, in the form of commodity booms and busts, is analyzed by employing a sustainable rural livelihoods framework, while a Chayanovian “balance” …

Full Issue: Winter 2014

DePaul Magazine

DePaul professors produce a documentary TV series highlighting impoverished communities globally and those who have come to their aid. Also, learn how DePaul's Steans Center implements service learning that broadens academics and supports the university's Vincentian mission, discover out-of-the-box teaching methods employed by innovative faculty, and meet an alumnus who's one of the music industry's most prominent sound engineers.

Full Issue: Summer 2015

DePaul Magazine

No abstract provided.

Not A Waste: Wastewater Surveillance To Enhance Public Health, Anna Gitter, Jeremiah Oghuan, Anuja Rajendra Godbole, Carlos A. Chavarria, Carlos Monserrat, Tao Hu, Yun Wang, Anthony W. Maresso, Blake M. Hanson, Kristina D. Mena, Fuqing Wu

Pharmacy Faculty Articles and Research

Domestic wastewater, when collected and evaluated appropriately, can provide valuable health-related information for a community. As a relatively unbiased and non-invasive approach, wastewater surveillance may complement current practices towards mitigating risks and protecting population health. Spurred by the COVID-19 pandemic, wastewater programs are now widely implemented to monitor viral infection trends in sewersheds and inform public health decision-making. This review summarizes recent developments in wastewater-based epidemiology for detecting and monitoring communicable infectious diseases, dissemination of antimicrobial resistance, and illicit drug consumption. Wastewater surveillance, a quickly advancing Frontier in environmental science, is becoming a new tool to enhance public health, improve …

The Axillary View Typically Does Not Contribute To Decision Making In Care For Proximal Humeral Fractures, Alfadl A Abdulfattah, Hanan A Jawkhab, Altaf A Alhazmi, Nada A Alfaifi, Maryam A Sultan, Rajaa A Alnami, Nada Y Kenani, Shorooq A Hamzi, Shahd M Abu Sharha, Ibrahim M Dighriri

Faculty, Staff and Student Publications

Background: Helicobacter pylori (H. pylori) is a severe infection responsible for upper gastrointestinal symptoms (UGISs). Several causes of H. pylori infection include food ingestion and person-to-person transmission. Many lifestyle variables can affect the occurrence of UGISs such as coffee consumption and smoking.

Objective: To assess the association between smoking and coffee consumption and the occurrence of UGISs in patients with active H. pylori infection in Jazan city in Saudi Arabia.

Methodology: A descriptive cross-sectional research design was used to conduct the study between July 2022 and August 2022 in Jazan, southern Saudi Arabia. Male and female Saudis or …

Fungal Assisted Valorisation Of Polymeric Lignin: Mechanism, Enzymes And Perspectives, Kavya Dashora, Meghana Gattupalli, Gyan Datta Tripathi, Zoya Javed, Shweta Singh, Maria Tuohy, Prakash Kumar Sarangi, Deepti Diwan, Harikesh B. Singh, Vijai Kumar Gupta

2020-Current year OA Pubs

No abstract provided.

Subunit Vaccine Targeting Phosphate Abc Transporter Atp-Binding Protein, Pstb, Provides Cross-Protection Against Streptococcus Suis Serotype 2, 7, And 9 In Mice, Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, X Ma, Nihua Dong, Jianchao Wei, K Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A. Jarvis, Mathew Upton, Xiangdong Li, Z Ma, J Liu, B Li

School of Biomedical Sciences

Streptococcus suis is a significant pathogen in pigs and a newly emerging zoonotic agent in humans. The presence of multiple serotypes and strains with diversified sequence types in pig herds highlights the need for the identification of broadly cross-reactive universal vaccine antigen targets, capable of providing cross-protection against S. suis infection. Subunit vaccines based on the conserved proteins shared between different S. suis serotypes are potential candidates for such a universally protective vaccine. In the present study, phosphate ABC transporter ATP-binding protein PstB (PstB), an immunogenic protein of the S. suis bacterium, was expressed and purified, and then subjected to …

Evaluation Of Serum Concentration Of Acute-Phase Proteins (Haptoglobin And Serum Amyloid A) In The Affected Arabian Foals With Rhodococcosis, Ali Hassanpour, Sina Moghaddam

Faculty, Staff and Students Publications

BACKGROUND: Early detection of Rhodococcus equi pneumonia in foals is essential for horse health and for veterinarians.

OBJECTIVES: This study aimed to demonstrate the usefulness of assessing the serum concentration of acute-phase proteins (APPs) in the early diagnosis of pneumonia.

METHODS: The study evaluated APPs in 19 Arabian foals with R. equi pneumonia and compared them with 18 normal Arabian foals in equestrian clubs in Tabriz, Iran. Affected foals were identified through history, clinical findings and bacterial culture of tracheal washing. Biochemical methods and polymerase chain reaction tests were performed by examining the 16S rRNA and vapA genes to confirm …

Subunit Vaccine Targeting Phosphate Abc Transporter Atp-Binding Protein, Pstb, Provides Cross-Protection Against Streptococcus Suis Serotype 2, 7, And 9 In Mice, Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, X Ma, Nihua Dong, Jianchao Wei, K Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A. Jarvis, Mathew Upton, X Li, Z Ma, J Liu, B Li

School of Biomedical Sciences

Streptococcus suis is a significant pathogen in pigs and a newly emerging zoonotic agent in humans. The presence of multiple serotypes and strains with diversified sequence types in pig herds highlights the need for the identification of broadly cross-reactive universal vaccine antigen targets, capable of providing cross-protection against S. suis infection. Subunit vaccines based on the conserved proteins shared between different S. suis serotypes are potential candidates for such a universally protective vaccine. In the present study, phosphate ABC transporter ATP-binding protein PstB (PstB), an immunogenic protein of the S. suis bacterium, was expressed and purified, and then subjected to …

Investigation Of The Effect Of Senescence On Daily Activity Patterns In Male Octopus Insularis, Mariam Steinblatt

Theses and Dissertations

Senescent male octopuses often show comparatively increased activity. We observed daily activity for an adult male Octopus insularis. The subject's diurnal behavior was marked movement or stationary to observe differences. Movement increased over 26 days, but the difference was non-significant. The observation period was likely short, and the subject already senescent.

The Impact Of Covid-19 On Pediatric Cardiac Arrest Outcomes: A Systematic Review And Meta-Analysis, Alla Navolokina, Jacek Smereka, Bernd W Böttiger, Michal Pruc, Raúl Juárez-Vela, Mansur Rahnama-Hezavah, Zubaid Rafique, Frank W Peacock, Kamil Safiejko, Lukasz Szarpak

Faculty, Staff and Students Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic, required the donning of personal protective equipment during clinical contact, and continues to be a significant worldwide public health concern. Pediatric cardiac arrest is a rare but critical condition with a high mortality rate, the outcomes of which may be negatively affected by donning personal protective equipment. The aim of this study is to perform a systematic review and meta-analysis of the impact of the COVID-19 pandemic on pediatric cardiac arrest outcomes. We conducted a systematic review with meta-analysis in the following databases: PubMed, EMBASE, Scopus, Web of Science, …

Chronic And Postprandial Metabolic Responses To A Ketogenic Diet Compared To High-Carbohydrate And Habitual Diets In Trained Competitive Cyclists And Triathletes: A Randomized Crossover Trial, Austin J. Graybeal, Andreas Kreutzer, Kamiah Moss, Petra Rack, Garrett Augsburger, Robyn Braun-Trocchio, Jada L. Willis, Meena Shah

Faculty Publications

Extreme carbohydrate deficits during a ketogenic diet (KD) may result in metabolic adaptations reflective of low energy availability; however, the manifestation of these adaptations outside of exercise have yet to be elucidated in cyclists and triathletes. The purpose of this study is to investigate the chronic and postprandial metabolic responses to a KD compared to a high-carbohydrate diet (HCD) and habitual diet (HD) in trained competitive cyclists and triathletes. For this randomized crossover trial, six trained competitive cyclist and triathletes (F: 4, M: 2) followed an ad libitum KD and HCD for 14 d each after their HD. Fasting energy …

Discovery And Characterization Of A New Class Of O-Linking Oligosaccharyltransferases From The Moraxellaceae Family, Cory J Knoot, Paeton L Wantuch, Lloyd S Robinson, David A Rosen, Nichollas E Scott, Christian M Harding

2020-Current year OA Pubs

Bacterial protein glycosylation is commonly mediated by oligosaccharyltransferases (OTases) that transfer oligosaccharides en bloc from preassembled lipid-linked precursors to acceptor proteins. Natively, O-linking OTases usually transfer a single repeat unit of the O-antigen or capsular polysaccharide to the side chains of serine or threonine on acceptor proteins. Three major families of bacterial O-linking OTases have been described: PglL, PglS, and TfpO. TfpO is limited to transferring short oligosaccharides both in its native context and when heterologously expressed in glycoengineered Escherichia coli. On the other hand, PglL and PglS can transfer long-chain polysaccharides when expressed in glycoengineered E. coli. Herein, we …