Digital Commons Network^™

Virome Analysis And Association Of Positive Coxsackievirus B Serology During Pregnancy With Congenital Heart Disease, Mathieu Garand, Susie S Y Huang, Lisa S Goessling, Fei Wan, Donna A Santillan, Mark K Santillan, Anoop Brar, Todd N Wylie, Kristine M Wylie, Pirooz Eghtesady

2020-Current year OA Pubs

BACKGROUND: We have previously shown coxsackievirus B (CVB) to be a potent inducer of congenital heart disease (CHD) in mice. The clinical relevance of these findings in humans and the roles of other viruses in the pathogenesis of CHD remain unknown.

METHODS: We obtained plasma samples, collected at all trimesters, from 89 subjects (104 pregnancies), 73 healthy controls (88 pregnancies), and 16 with CHD-affected birth (16 pregnancies), from the Perinatal Family Tissue Bank (PFTB). We performed CVB IgG/IgM serological assays on plasma. We also used ViroCap sequencing and PCR to test for viral nucleic acid in plasma, circulating leukocytes from …

Montana Kaimin, January 19, 2023, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

"Understanding Transgender Identities: Four Views" [Review] / Beilby, James K. And Paul Rhodes Eddy, Eds. ., Ronald Rojas

Andrews University Seminary Studies (AUSS)

This is a book review

Socio-Demographic Determinants Of Non-Utilisation Of Antenatal Care Services By Women In The Northern Region Of Nigeria, Abubakar Yakubu Abbani, Yothin Sawangdee, Olusola Akintoye Omisakin, Maretalinia Maretalinia

Journal of Health Research

Background: A large proportion of women in the northern region of Nigeria do not utilise antenatal care (ANC) services. As a result, the region has the worst maternal and child health indicators. This study aims to identify the socio-demographic determinants of the non-utilisation of ANC services by pregnant women to provide evidence for policymakers to base decisions towards addressing the problem.

Methods: Data from the 2018 Nigeria Demographic and Health Survey was used with a sample of 14,421 women with a pregnancy history. Descriptive, bivariate, and hierarchical regression analyses were applied to the data using STATA software version 15.

Results: …

Kantian Ethics And Our Duties To Nonhuman Animals, Samuel Kahn

Between the Species

Many take Kantian ethics to founder when it comes to our duties to animals. In this paper, I advocate a novel approach to this problem. The paper is divided into three sections. In the first, I canvass various passages from Kant in order to set up the problem. In the second, I introduce a novel approach to this problem. In the third, I defend my approach from various objections. By way of preview: I advocate rejecting the premise that nonhuman animals are nonrational.

Smokejumper Biographies For 1953 Rookie Class, K-W, National Smokejumper Association

Smokejumper Biographies by Rookie Year

This document contains short biographies of smokejumpers who rookied in 1953.

Artificial Intelligence For Automated Detection Of Large Mammals Creates Path To Upscale Drone Surveys, Javier Lenzi, Andrew Barnas, Abdelrahman A. Elsaid, Travis Desell, Robert F. Rockwell, Susan N. Ellis-Felege

Biology Faculty Publications

Imagery from drones is becoming common in wildlife research and management, but processing data efficiently remains a challenge. We developed a methodology for training a convolutional neural network model on large-scale mosaic imagery to detect and count caribou (Rangifer tarandus), compare model performance with an experienced observer and a group of naïve observers, and discuss the use of aerial imagery and automated methods for large mammal surveys. Combining images taken at 75 m and 120 m above ground level, a faster region-based convolutional neural network (Faster-RCNN) model was trained in using annotated imagery with the labels: “adult …

Microplastics In Mainstem Mississippi River Fishes, Ahmed K. Gad, Kerrin Toner, Mark C. Benfield, Stephen R. Midway

Faculty Publications

Microplastics are ubiquitous in Earth’s ecosystems and many efforts have begun to understand their distributions. Large rivers, like the Mississippi River, provide a unique system in which to look at large-scale patterns of microplastic distribution. In this study, we sampled four species of widely-distributed fishes from five sites along the mainstem Mississippi River, from Minnesota to Louisiana, United States. Microplastics were found in all fish species and at all sites; however, microplastics increased in occurrence in the Lower Mississippi River. Fragments were the most common morphologies and polypropylene was the most common polymer detected. We also examined the hypothesis that …

Speculative Constitutions In Ursula K. Le Guin’S Hainish Cycle And The Rights Of Nature, Ted Hamilton

Faculty Journal Articles

This paper examines two speculative examinations of humanity as a unified species and agent of ecological change: Ursula K. Le Guin’s Hainish Cycle and the rights of nature movement. Le Guin’s Cycle imagines the slow interplanetary reintegration of human polities against a backdrop of cultural and environmental difference. I read the novels of the Cycle as an allegory for the rights of nature movement, which seeks to synthesize traditional and modern knowledge in a legal solution to ecological crisis. Both discourses, I argue, productively imagine a new historical understanding of humanity’s place on Earth, but they provide a weak theory …

G Protein-Coupled Receptor Kinase-2 (Grk-2) Controls Exploration Through Neuropeptide Signaling In Caenorhabditis Elegans, Kristen Davis, Christo Mitchell, Olivia Weissenfels, Jihong Bai, David M. Raizen, Michael Ailion, Irini Topalidou

Department of Neuroscience Faculty Papers

Animals alter their behavior in manners that depend on environmental conditions as well as their developmental and metabolic states. For example, C. elegans is quiescent during larval molts or during conditions of satiety. By contrast, worms enter an exploration state when removed from food. Sensory perception influences movement quiescence (defined as a lack of body movement), as well as the expression of additional locomotor states in C. elegans that are associated with increased or reduced locomotion activity, such as roaming (exploration behavior) and dwelling (local search). Here we find that movement quiescence is enhanced, and exploration behavior is reduced in …

Heifers On Feed Indicate Long-Term Liquidation Still Occurring, Elliott James Dennis

Cornhusker Economics

This article was first published in the Livestock Marketing Information Centers' (LMIC) In the Cattle Markets newsletter on January 9, 2023.

Combining the historical quarterly percentage of heifers on feed and cattle inventory report can provide an indicator of how many heifers will be held back for replacement in the 2023 report.

Multi-Frame Optical Flow Estimation Using Spatio-Temporal Transformers, Fisseha Admasu Ferede

Electronic Theses and Dissertations Archive

Optical flow estimation is a computer vision problem which aims to estimate apparent 2D motion (flow velocities) of image intensities between two or more consecutive frames in an image sequence. Optical flow information is useful for quantifying dense motion field in numerous applications such as autonomous driving, object tracking in traffic control systems, video frame interpolation, video compression and structural biomarker development for medical diagnosis. Recent state of the art learning methods for optical flow estimation are two-frame based methods where optical flow is estimated sequentially for each image pairs in an image sequence. In this work, we introduce a …

A Rodent Model For Dirofilaria Immitis, Canine Heartworm: Parasite Growth, Development, And Drug Sensitivity In Nsg Mice, Jessica A. Hess, Mark L. Eberhard, Marcelo Segura-Lepe, Kathrin Grundner-Culemann, Barbara Kracher, Jeffrey Shryock, John Harrington, David Abraham

Department of Microbiology and Immunology Faculty Papers

Heartworm disease, caused by Dirofilaria immitis, remains a significant threat to canines and felines. The development of parasites resistant to macrocyclic lactones (ML) has created a significant challenge to the control of the infection. The goal of this study was to determine if mice lacking a functional immune response would be susceptible to D. immitis. Immunodeficient NSG mice were susceptible to the infection, sustaining parasites for at least 15 weeks, with infective third-stage larvae molting and developing into the late fourth-stage larvae. Proteomic analysis of host responses to the infection revealed a complex pattern of changes after infection, with at …

Smokejumper Biographies For 1953 Rookie Class, A-J, National Smokejumper Association

Smokejumper Biographies by Rookie Year

This document contains short biographies of smokejumpers who rookied in 1953.

The Parthenon, January 18, 2023, Evan Green, Conner Woodruff, Matt Schaffer, Chayce Matheny, Victoria Ware, Shauntelle Thompson, Rafael Alfonso, Abby Hanlon

The Parthenon

No abstract provided.

Dynamic Imine Bonding Facilitates Mannan Release From A Nanofibrous Peptide Hydrogel, Brett H Pogostin, Gabriel Saenz, Carson C Cole, Erin M Euliano, Jeffrey D Hartgerink, Kevin J Mchugh

Faculty, Staff and Student Publications

Recently, there has been increased interest in using mannan as an immunomodulatory bioconjugate. Despite notable immunological and functional differences between the reduced (R-Man) and oxidized (O-Man) forms of mannan, little is known about the impact of mannan oxidation state on its in vivo persistence or its potential controlled release from biomaterials that may improve immunotherapeutic or prophylactic efficacy. Here, we investigate the impact of oxidation state on the in vitro and in vivo release of mannan from a biocompatible and immunostimulatory multidomain peptide hydrogel, K2(SL)6K2 (abbreviated as K2), that has been previously used for the controlled release of protein and …

Seasonal Plasticity In Morphology And Metabolism Differs Between Migratory North American And Resident Costa Rican Monarch Butterflies, Ayşe Tenger-Trolander, Cole R. Julick, Wei Lu, Delbert André Green, Kristi L. Montooth, Marcus R. Kronforst

School of Biological Sciences: Faculty Publications

Environmental heterogeneity in temperate latitudes is expected to maintain seasonally plastic life-history strategies that include the tuning of morphologies and metabolism that support overwintering. For species that have expanded their ranges into tropical latitudes, it is unclear the extent to which the capacity for plasticity will be maintained or will erode with disuse. The migratory generations of the North American (NA) monarch butterfly Danaus plexippus lead distinctly different lives from their summer generation NA parents and their tropical descendants living in Costa Rica (CR). NA migratory monarchs postpone reproduction, travel thousands of kilometers south to overwinter in Mexico, and subsist …

Methylene Blue Inhibits Cromakalim-Activated K+ Currents In Follicle-Enclosed Oocytes, Dmytro Isaev, Keun-Hang Susan Yang, Georg Petroianu, Dietrich Ernst Lorke, Murat Oz

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The effects of methylene blue (MB) on cromakalim-induced K⁺ currents were investigated in follicle-enclosed Xenopus oocytes. In concentrations ranging from 3–300 μM, MB inhibited K⁺ currents (IC₅₀: 22.4 μM) activated by cromakalim, which activates K_ATP channels. MB inhibited cromakalim-activated K⁺ currents in a noncompetitive and voltage-independent manner. The respective EC₅₀ and slope values for cromakalim-activation of K⁺ currents were 194 ± 21 µM and 0.91 for controls, and 206 ± 24 µM and 0.87 in the presence of 30 μM MB. The inhibition of cromakalim-induced K⁺ currents by MB was not …

The Safety Of Appropriate Use Of Over-The-Counter Proton Pump Inhibitors: An Evidence-Based Review And Delphi Consensus, Wilfredo De Jesús-Rojas, Jesús Meléndez-Montañez, José Muñiz-Hernández, André Marra-Nazario, Francisco Alvarado-Huerta, Arnaldo Santos-López, Marcos J Ramos-Benitez, Ricardo A Mosquera

Faculty, Staff and Student Publications

The radial spoke head protein 4 homolog A (RSPH4A) gene is one of more than 50 genes that cause Primary ciliary dyskinesia (PCD), a rare genetic ciliopathy. Genetic mutations in the RSPH4A gene alter an important protein structure involved in ciliary pathogenesis. Radial spoke proteins, such as RSPH4A, have been conserved across multiple species. In humans, ciliary function deficiency caused by RSPH4A pathogenic variants results in a clinical phenotype characterized by recurrent oto-sino-pulmonary infections. More than 30 pathogenic RSPH4A genetic variants have been associated with PCD. In Puerto Rican Hispanics, a founder mutation (RSPH4A (c.921+3_921+6delAAGT (intronic)) has …

The “Evolving” Role Of Intravascular Imaging In Myocardial Infarction With Nonobstructive Coronary Arteries, D L Fischman, Vaikom S. Mahadevan, Eric R. Bates

Division of Internal Medicine Faculty Papers & Presentations

No abstract provided.

The Effect Of Firm Size And Financial Distress On Going Concern Audit Opinion, Muhammad Arya Lokamandala, Poppy Sofia Koeswayo, Devianti Yunita Harahap

Journal of Accounting Auditing and Business

This study aims to analyze the effect of firm size and financial distress on the reception of the going concern audit opinion in the Accommodation and Food and Beverages Sub-Sector listed in the Indonesian Stock Exchange between 2019 and 2021. This study employed the quantitative approach and the methods of descriptive and verification analysis. The data analyzed in this study came from secondary sources. The data were analyzed using descriptive and logistic regression analysis. These analyses show that firm size and financial distress do not significantly impact the going concern audit opinion in the Accommodation and Food and Beverages sector …

Epigenetic Resetting In The Human Germ Line Entails Histone Modification Remodeling, Wolfram H Gruhn, Walfred W C Tang, Sabine Dietmann, João P Alves-Lopes, Christopher A Penfold, Frederick C K Wong, Navin B Ramakrishna, M Azim Surani

2020-Current year OA Pubs

Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which lays the foundation for gametogenesis, totipotency, and embryonic development. We characterize the epigenome of hypomethylated human primordial germ cells (hPGCs) to reveal mechanisms preventing the widespread derepression of genes and transposable elements (TEs). Along with the loss of DNA methylation, we show that hPGCs exhibit a profound reduction of repressive histone modifications resulting in diminished heterochromatic signatures at most genes and TEs and the acquisition of a neutral or paused epigenetic state without transcriptional activation. Efficient maintenance of a heterochromatic state is limited to a subset of genomic …

Generation Of A Tree Shrew Breast Cancer Model Using Lentivirus Expressing Pik3ca-H1047r, Li Zeng, Hong-Yan Zhang, Chuan-Yu Yang, Zhuo Cheng, Qiu-Yun Jiang, Yao Luo, Yi Li, Fu-Bing Li, Ce-Shi Chen

Faculty, Staff and Students Publications

No abstract provided.

Association Of Omega 3 Polyunsaturated Fatty Acids With Incident Chronic Kidney Disease: Pooled Analysis Of 19 Cohorts, Kwok Leung Ong, Matti Marklund, Liping Huang, Kerry-Anne Rye, Nicholas Hui, Xiong-Fei Pan, Casey M Rebholz, Hyunju Kim, Lyn M Steffen, Anniek C Van Westing, Johanna M Geleijnse, Ellen K Hoogeveen, Yun-Yu Chen, Kuo-Liong Chien, Amanda M Fretts, Rozenn N Lemaitre, Fumiaki Imamura, Nita G Forouhi, Nicholas J Wareham, Anna Birukov, Susanne Jäger, Olga Kuxhaus, Matthias B Schulze, Vanessa Derenji De Mello, Jaakko Tuomilehto, Matti Uusitupa, Jaana Lindström, Nathan Tintle, William S Harris, Keisuke Yamasaki, Yoichiro Hirakawa, Toshiharu Ninomiya, Toshiko Tanaka, Luigi Ferrucci, Stefania Bandinelli, Jyrki K Virtanen, Ari Voutilainen, Tharusha Jayasena, Anbupalam Thalamuthu, Anne Poljak, Sonia Bustamante, Perminder S Sachdev, Mackenzie K Senn, Stephen S Rich, Michael Y Tsai, Alexis C Wood, Markku Laakso, Maria Lankinen, Xiaowei Yang, Liang Sun, Huaixing Li, Xu Lin, Christoph Nowak, Johan Ärnlöv, Ulf Risérus, Lars Lind, Mélanie Le Goff, Cécilia Samieri, Catherine Helmer, Frank Qian, Renata Micha, Adrienne Tin, Anna Köttgen, Ian H De Boer, David S Siscovick, Dariush Mozaffarian, Jason Hy Wu

Faculty, Staff and Students Publications

OBJECTIVE: To assess the prospective associations of circulating levels of omega 3 polyunsaturated fatty acid (n-3 PUFA) biomarkers (including plant derived α linolenic acid and seafood derived eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) with incident chronic kidney disease (CKD).

DESIGN: Pooled analysis.

DATA SOURCES: A consortium of 19 studies from 12 countries identified up to May 2020.

STUDY SELECTION: Prospective studies with measured n-3 PUFA biomarker data and incident CKD based on estimated glomerular filtration rate.

DATA EXTRACTION AND SYNTHESIS: Each participating cohort conducted de novo analysis with prespecified and consistent exposures, outcomes, covariates, and models. The results were …

Expanding Potential Dental Applications Of Glass Ionomer Cement By Incorporating With Nano-Hydroxyapatite, Kifayah K. Thbayh, Rafid M. Albadr, Kareema M. Ziadan, Béla Fiser

Karbala International Journal of Modern Science

Glass ionomer cement (GIC) is a common restorative material in dentistry, but it exhibits relatively weak mechanical properties. The present study focuses on incorporating nano-hydroxyapatite (nHAP) with different ratios (1, 3, 5, and 7wt%) in GIC to improve its properties. Mechanical properties, sorption, solubility, and diffusion coefficients after storage in distilled water for 60 days were studied. The highest sorption was measured at 7%wt (46.66 µg/mm3), and the lowest solubility was in the case of the sample containing 5% (29.166 µg/mm3). Moreover, the highest value of diffu-sion coefficient was 8.5 mm/s in the case of the sample with 7%wt nHAP. …

Illuminating Chinese Aesthetics With Kant’S Account Of Genius? Possibility And Difficulty, Kefu Zhu

Comparative Philosophy

Many scholars interpret Chinese Aesthetics with the Kantian theory of genius because they seem to form a parallel: similar innate and spontaneous mental talents that exceed normal cognition and imagination generates beautiful arts with similar extraordinary qualities. I argue that projecting Kant’s genius to illuminate the creative power analogically, i.e., the carefree-wandering mind, is infeasible. The theory of genius assumes a critical project that stipulates a valuable way to exercise the power of judgment. Genius is only a postulated idea for successfully making aesthetic judgments on artworks. In contrast, the carefree-wandering mind assumes a Daoist metaphysical-ethical theory centering on the …

How Al-Farabi’S Interpretative Method Can Engage With Aristotle’S Method In Cognition And Practical Philosophy, Meysam Shirvani

Comparative Philosophy

Following Aristotle, al-Farabi divides philosophy into theoretical and practical each of which requires some specific methodology both in interpretation and cognition. Based on this division, there may arguably be four methodologies for four parts: 1) cognition of theoretical philosophy 2) interpretation of practical philosophy 3) cognition of practical philosophy 4) interpretation of practical philosophy. This paper focuses on the last one: the methodology of interpreting practical philosophy. Al-Farabi has an undeniably significant contribution to practical philosophy as a commentator on Greek philosophy and as a founder. In this paper, I investigate how al-Farabi (870-950 AD) read classical practical philosophy to …

Full Issue: Volume 1, Issue 1, Editorial Board

Crossings: Swarthmore Undergraduate Feminist Research Journal

No abstract provided.

Sex In The Bible: A Poetic Female Retelling, Gabriella Raffetto

Crossings: Swarthmore Undergraduate Feminist Research Journal

In my poetic analysis, I tease out the differences between Biblical and modern conceptions of rape. Many of my ‘episodes’ feature rape narratives between a husband and wife or concubine/slave; in the Biblical narrative, these relations were not considered rape, because rape only constituted relationships outside of legal bounds. In this way, I attempt to diversify preexisting stories in the Biblical narrative, making monsters out of praised patriarchs; even God is not safe from becoming the villain. In this way, I paint the patriarchal system in the Bible as a gothic house disguised in tradition and spirituality that women must …

Àṣẹ After Man: The Rupture Of The Christian-Colonial Project As Decolonial Ceremony, Eden Segbefia

Crossings: Swarthmore Undergraduate Feminist Research Journal

This project is a theoretical exploration of the Yoruba concept of àṣẹ and its role in unsettling the hierarchies imposed by Christian colonialism. Sylvia Wynter's explanation of the ways in which Christian colonialism has affected the very concept of Man proves crucial here. Àṣẹ is an example of a decolonial concept because of its ability to rearrange animacy, especially as it is conceived in Western European epistemology. Wynter and other interlocutors are utilized to support this argument and imagine new possibilities in considering the relationships between Christian colonialism, alterity, plasticity, and animacy.